Mononuclear Chelates: Synthesis, DNA Interaction and Biological Studies

What is it about?

In this study three innovative VO(II), Cr(III) and Ni(II) imine complexes have been synthesized and their structures have been characterized by physicochemical and spectral tools. The obtained results demonstrated that the HNAP imine pro-ligand behaves as dibasic tridentate ONO ligand and coordinates to VO(II), Cr(III) and Ni(II) in 1:1 molar ratio. From the analytical and spectral data, it is observed that the complexes adopted octahedral geometry in case of Cr(III), tetrahedral geometry in Ni(II) and distorted square pyramidal geometry in VO(II). The anti-pathogenic screening showed that these complexes are perfect antimicrobial agents against different organisms and standards. Moreover, the interaction of the complexes with CT-DNA has been effectively examined and explored by electronic absorption, viscosity measurements and gel electrophoresis. The DNA interaction studies propose the intercalative and replacement modes of interaction. Furthermore, the growth inhibitory effect of the prepared compounds was tested on HepG-2, HCT-116 and MCF-7cancer cells. Among these compounds, the compound HNAPV significantly decreases the cell viability time and dose dependently. These biological findings from our study would be helpful in perceptive of DNA interaction exposed by metal complexes and may progress to improve novel metal based therapeutic drugs.

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