Anti-QS/Anti-Biofilm Agents in Controlling Bacterial Disease: An in silico Approach

What is it about?

Various classical and integrated approaches are applied in different parts of the globe for bacterial disease management. Strategies like biocontrol agents and use of inducer of systemic resistance (SAR) have been proposed as an effective means to control bacterial diseases. Quorum sensing (QS) and biofilms are now considered as anti-infective target to control bacterial infection. This chapter presents a brief description of the role of QS and biofilms in disease control. It describes basic in silico approaches for target identification, modeling, and data extraction. Further, the chapter also elaborates virtual screening (VS) for identification of potent anti-QS agents. Identification of compounds having inhibitory property for QS is a promising way to control biofilm formation where the antibiotics are not effective. Many researchers have reported QS inhibitory property of different compounds derived …

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