What is it about?

This work mainly focuses on synthesis of β-nitrostyrene derivatives for quorum sensing inhibition against Serratia marcescens, investgated by by Jiang Wang, Jing-Yi Yang, Pradeepraj Durairaj, Wei Wang, Dong-Yan Wei, Shi Tang, Hai-Qing Liu, Dayong Wang, and Ai-Qun Jia for the great work and successfully publish in mLife recently. In detail, QS inhibition has emerged as a promising target for directed drug design, providing an appealing strategy for developing antimicrobials, particularly against infections caused by drug‐resistant pathogens.

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Why is it important?

The World Health Organization (WHO) has highlighted antibiotic resistance as the third most serious threat to human health, and there is an urgent need to discover alternative therapeutic options that may successfully prevent antibiotic overuse/abuse. Serratia spp. an opportunistic pathogen causes a variety of illnesses, including pneumonia, nosocomial bacteremia, wound, and urinary tract infections. Quorum sensing (QS) is a bacterial density-dependent gene expression mechanism that involves the binding of receptors and autoinducers to govern pathogenic bacteria (swarming, swimming, and biofilm formation) by producing virulence factors, which can diminish antibiotic efficacy. This novel concept may broaden the usage of antibiotics while preventing antimicrobial resistance (AMR) in humans. So in this investigation, author developed, synthesized, and evaluated β-nitrostyrenes derivatives to identify a novel class of QSIs against S. marcescens. Based on our findings, m-NPe has the potential to be developed as an effective and efficient QSI and antibiofilm agent for treating microbial infection and can evolve as an alternative clinical drug in the future.

Perspectives

So far, these results significantly confirmed m‐NPe's potential as an effective QSI and antibiofilm agent against antimicrobial‐resistant S. marcescens, with implications for enhancing medication sensitivity and clinical therapeutic administration, and provided m‐NPe as a promising candidate for future development of new medicines against microbial infections. However, we also have many related works to do for best understand and clareify it thorough, this just is a phasic research result.

Jiang Wang

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This page is a summary of: Discovery of β‐nitrostyrene derivatives as potential quorum sensing inhibitors for biofilm inhibition and antivirulence factor therapeutics against Serratia marcescens, mLife, September 2024, Tsinghua University Press,
DOI: 10.1002/mlf2.12135.
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