All Stories

  1. Development of an In Vitro Human Thyroid Microtissue Model for Chemical Screening

    Article • Toxicological Sciences, December 2019, Oxford University Press (OUP)

    Dr Russell S Thomas

  2. The next generation blueprint of computational toxicology at the U.S. Environmental Protection Agency

    Article • Toxicological Sciences, March 2019, Oxford University Press (OUP)

    Dr Antony John Williams, Dr John Fredrick Wambaugh, Dr Russell S Thomas

  3. DEVELOPMENT OF A CURATED HERSHBERGER DATABASE

    Article • Reproductive Toxicology, September 2018, Elsevier

    Dr Richard S Judson, Dr Russell S Thomas

  4. Accelerating the Pace of Chemical Risk Assessment

    Article • Chemical Research in Toxicology, March 2018, American Chemical Society (ACS)

    Dr Russell S Thomas

  5. Aryl hydrocarbon receptor knockout rats are insensitive to the pathological effects of repeated oral exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin

    Article • Journal of Applied Toxicology, August 2015, Wiley

    Dr Russell S Thomas

  6. Screening Chemicals for Estrogen Receptor Bioactivity Using a Computational Model

    Article • Environmental Science & Technology, July 2015, American Chemical Society (ACS)

    Dr Richard S Judson, Dr Russell S Thomas, Dr Nicole Kleinstreuer

  7. Technical guide for applications of gene expression profiling in human health risk assessment of environmental chemicals

    Article • Regulatory Toxicology and Pharmacology, July 2015, Elsevier

    Dr Russell S Thomas, Pierre R Bushel

  8. Predicting Hepatotoxicity Using ToxCastin VitroBioactivity and Chemical Structure

    Article • Chemical Research in Toxicology, April 2015, American Chemical Society (ACS)

    Dr kamel mansouri, Dr Richard S Judson, Dr Russell S Thomas, Dr Kamel Mansouri, Dr Antony John Williams

  9. Identifying genes that mediate anthracyline toxicity in immune cells

    Article • Frontiers in Pharmacology, April 2015, Frontiers

    Dr Russell S Thomas

  10. Correction: Identification of Modulators of the Nuclear Receptor Peroxisome Proliferator-Activated Receptor α (PPARα) in a Mouse Liver Gene Expression Compendium

    Article • PLoS ONE, April 2015, PLOS

    Dr Russell S Thomas

  11. Identification of Modulators of the Nuclear Receptor Peroxisome Proliferator-Activated Receptor α (PPARα) in a Mouse Liver Gene Expression Compendium

    Article • PLoS ONE, February 2015, PLOS

    Dr Russell S Thomas

  12. Immune cell-based screening assay for response to anticancer agents: applications in pharmacogenomics

    Article • Pharmacogenomics and Personalized Medicine, February 2015, Taylor & Francis

    Dr Amber Frick, Dr Kristy L Richards, Dr Russell S Thomas

  13. Lineage‐dependent effects of aryl hydrocarbon receptor agonists contribute to liver tumorigenesis

    Article • Hepatology, January 2015, Wiley

    Dr Russell S Thomas

  14. The Human Toxome Project

    Article • ALTEX, January 2015, ALTEX Edition

    Dr Kevin M Crofton, Dr Russell S Thomas

  15. MYC Is an Early Response Regulator of Human Adipogenesis in Adipose Stem Cells

    Article • PLoS ONE, December 2014, PLOS

    Dr Russell S Thomas

  16. Aryl hydrocarbon receptor knock‐out exacerbates choroidal neovascularization via multiple pathogenic pathways

    Article • The Journal of Pathology, October 2014, Wiley

    Dr Russell S Thomas

  17. Transcriptional responses in the rat nasal epithelium following subchronic inhalation of naphthalene vapor

    Article • Toxicology and Applied Pharmacology, October 2014, Elsevier

    Dr Russell S Thomas

  18. A cellular genetics approach identifies gene-drug interactions and pinpoints drug toxicity pathway nodes

    Article • Frontiers in Genetics, August 2014, Frontiers

    Dr Russell S Thomas

  19. Incorporating Population Variability and Susceptible Subpopulations into Dosimetry for High-Throughput Toxicity Testing

    Article • Toxicological Sciences, August 2014, Oxford University Press (OUP)

    Dr John Fredrick Wambaugh, Dr Russell S Thomas

  20. Development of 3D Dynamic Flow Model of Human Liver and Its Application to Prediction of Metabolic Clearance of 7-Ethoxycoumarin

    Article • Tissue Engineering Part C Methods, August 2014, Mary Ann Liebert Inc

    Dr Russell S Thomas

  21. In Vitroand Modelling Approaches to Risk Assessment from the U.S. Environmental Protection Agency ToxCast Programme

    Article • Basic & Clinical Pharmacology & Toxicology, April 2014, Wiley

    Dr Richard S Judson, Dr Keith Houck, Dr John Fredrick Wambaugh, Dr Kevin M Crofton, Dr Russell S Thomas

  22. Erratum

    Article • Toxicological Sciences, January 2014, Oxford University Press (OUP)

    Dr Richard S Judson, Dr John Fredrick Wambaugh, Dr Russell S Thomas

  23. EN

    Article • ALTEX, January 2014, ALTEX Edition

    Dr Russell S Thomas

  24. IVT-seq reveals extreme bias in RNA sequencing

    Article • Genome Biology, January 2014, Springer Science + Business Media

    Dr Russell S Thomas

  25. Comparison of Microarrays and RNA-Seq for Gene Expression Analyses of Dose-Response Experiments

    Article • Toxicological Sciences, November 2013, Oxford University Press (OUP)

    Dr Russell S Thomas

  26. Subchronic toxicity evaluation of potassium bromate in Fischer 344 rats

    Article • Environmental Toxicology and Pharmacology, November 2013, Elsevier

    Dr Russell S Thomas

  27. Aryl hydrocarbon receptor deficiency causes dysregulated cellular matrix metabolism and age-related macular degeneration-like pathology

    Article • Proceedings of the National Academy of Sciences, October 2013, Proceedings of the National Academy of Sciences

    Dr Russell S Thomas

  28. Knockout of the aryl hydrocarbon receptor results in distinct hepatic and renal phenotypes in rats and mice

    Article • Toxicology and Applied Pharmacology, October 2013, Elsevier

    Dr Russell S Thomas

  29. A Genomics-Based Analysis of Relative Potencies of Dioxin-Like Compounds in Primary Rat Hepatocytes

    Article • Toxicological Sciences, September 2013, Oxford University Press (OUP)

    Dr Russell S Thomas

  30. A Multi-Stakeholder Perspective on the Use of Alternative Test Strategies for Nanomaterial Safety Assessment

    Article • ACS Nano, August 2013, American Chemical Society (ACS)

    Dr Russell S Thomas

  31. Subchronic Toxicity Evaluation of Anthraquinone in Fischer 344 Rats

    Article • International Journal of Toxicology, August 2013, SAGE Publications

    Dr Russell S Thomas

  32. Incorporating New Technologies Into Toxicity Testing and Risk Assessment: Moving From 21st Century Vision to a Data-Driven Framework

    Article • Toxicological Sciences, August 2013, Oxford University Press (OUP)

    Dr Russell S Thomas

  33. Biological Networks for Predicting Chemical Hepatocarcinogenicity Using Gene Expression Data from Treated Mice and Relevance across Human and Rat Species

    Article • PLoS ONE, May 2013, PLOS

    Dr Russell S Thomas

  34. Temporal Concordance Between Apical and Transcriptional Points of Departure for Chemical Risk Assessment

    Article • Toxicological Sciences, April 2013, Oxford University Press (OUP)

    Dr Russell S Thomas

  35. All-or-none suppression of B cell terminal differentiation by environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin

    Article • Toxicology and Applied Pharmacology, April 2013, Elsevier

    Dr Russell S Thomas

  36. Incorporating Human Dosimetry and Exposure Information with High-Throughput Screening Data in Chemical Toxicity Assessment

    Article • March 2013, Wiley

    Dr Russell S Thomas

  37. Relative Impact of Incorporating Pharmacokinetics on Predicting In Vivo Hazard and Mode of Action from High-Throughput In Vitro Toxicity Assays

    Article • Toxicological Sciences, January 2013, Oxford University Press (OUP)

    Dr Richard S Judson, Dr John Fredrick Wambaugh, Dr Russell S Thomas

  38. The Aryl-Hydrocarbon Receptor Protein Interaction Network (AHR-PIN) as Identified by Tandem Affinity Purification (TAP) and Mass Spectrometry

    Article • Journal of Toxicology, January 2013, Hindawi Publishing Corporation

    Dr Russell S Thomas

  39. Evaluation of gene expression changes in human primary uroepithelial cells following 24-Hr exposures to inorganic arsenic and its methylated metabolites

    Article • Environmental and Molecular Mutagenesis, November 2012, Wiley

    Dr Russell S Thomas

  40. Cross-Species Transcriptomic Analysis of Mouse and Rat Lung Exposed to Chloroprene

    Article • Toxicological Sciences, November 2012, Oxford University Press (OUP)

    Dr Russell S Thomas

  41. Subchronic Hepatotoxicity Evaluation of Hydrazobenzene in Fischer 344 Rats

    Article • International Journal of Toxicology, November 2012, SAGE Publications

    Dr Russell S Thomas

  42. Response to "Incorporating Biological, Chemical, and Toxicological Knowledge Into Predictive Models of Toxicity"

    Article • Toxicological Sciences, September 2012, Oxford University Press (OUP)

    Dr Russell S Thomas

  43. Subchronic urinary bladder toxicity evaluation of N-Nitrosodiphenylamine in Fischer 344 rats

    Article • Journal of Applied Toxicology, August 2012, Wiley

    Dr Russell S Thomas

  44. Integrating pathway-based transcriptomic data into quantitative chemical risk assessment: A five chemical case study

    Article • Mutation Research/Genetic Toxicology and Environmental Mutagenesis, August 2012, Elsevier

    Dr Russell S Thomas

  45. Subchronic Thyroid Toxicity Evaluation of 4,4′-Methylenebis(N,N′-Dimethyl)Aniline in Fischer 344 Rats

    Article • Journal of Toxicology and Environmental Health Part A, June 2012, Taylor & Francis

    Dr Russell S Thomas

  46. A Comprehensive Statistical Analysis of Predicting In Vivo Hazard Using High-Throughput In Vitro Screening

    Article • Toxicological Sciences, April 2012, Oxford University Press (OUP)

    Dr Russell S Thomas

  47. Response to "Accurate Risk-Based Chemical Screening * Relies on Robust Exposure Estimates"

    Article • Toxicological Sciences, April 2012, Oxford University Press (OUP)

    Dr Richard S Judson, Dr John Fredrick Wambaugh, Dr Russell S Thomas

  48. Subchronic Hepatotoxicity Evaluation of 1,2,4-Tribromobenzene in Sprague-Dawley Rats

    Article • International Journal of Toxicology, April 2012, SAGE Publications

    Dr Russell S Thomas

  49. Subchronic hepatotoxicity evaluation of bromobenzene in Fischer 344 rats

    Article • Journal of Applied Toxicology, March 2012, Wiley

    Dr Russell S Thomas

  50. Cross-species Comparisons of Transcriptomic Alterations in Human and Rat Primary Hepatocytes Exposed to 2,3,7,8-Tetrachlorodibenzo-p-dioxin

    Article • Toxicological Sciences, February 2012, Oxford University Press (OUP)

    Dr Russell S Thomas

  51. Biological responses in rats exposed to cigarette smoke and Middle East sand (dust)

    Article • Inhalation Toxicology, January 2012, Taylor & Francis

    Dr Russell S Thomas

  52. Subchronic Hepatotoxicity Evaluation of 2,3,4,6-Tetrachlorophenol in Sprague Dawley Rats

    Article • Journal of Toxicology, January 2012, Hindawi Publishing Corporation

    Dr Russell S Thomas

  53. Integration of Dosimetry, Exposure, and High-Throughput Screening Data in Chemical Toxicity Assessment

    Article • Toxicological Sciences, September 2011, Oxford University Press (OUP)

    Dr Richard S Judson, Dr John Fredrick Wambaugh, Dr Russell S Thomas

  54. The aryl hydrocarbon receptor interacts with ATP5α1, a subunit of the ATP synthase complex, and modulates mitochondrial function

    Article • Toxicology and Applied Pharmacology, August 2011, Elsevier

    Dr Russell S Thomas

  55. Concentration- and Time-dependent Genomic Changes in the Mouse Urinary Bladder Following Exposure to Arsenate in Drinking Water for up to 12 Weeks

    Article • Toxicological Sciences, July 2011, Oxford University Press (OUP)

    Dr Russell S Thomas

  56. Analysis of Transcriptomic Dose-Response Data for Toxicology and Risk Assessment

    Article • July 2011, Wiley

    Dr Russell S Thomas

  57. Estimating Toxicity-Related Biological Pathway Altering Doses for High-Throughput Chemical Risk Assessment

    Article • Chemical Research in Toxicology, April 2011, American Chemical Society (ACS)

    Dr Richard S Judson, Dr Keith Houck, Dr Russell S Thomas

  58. Regulation of Bach2 by the aryl hydrocarbon receptor as a mechanism for suppression of B-cell differentiation by 2,3,7,8-tetrachlorodibenzo-p-dioxin

    Article • Toxicology and Applied Pharmacology, April 2011, Elsevier

    Dr Russell S Thomas

  59. Systems pharmacology assessment of the 5-fluorouracil pathway

    Article • Pharmacogenomics, March 2011, Future Medicine

    Dr Russell S Thomas

  60. Application of Transcriptional Benchmark Dose Values in Quantitative Cancer and Noncancer Risk Assessment

    Article • Toxicological Sciences, November 2010, Oxford University Press (OUP)

    Dr Russell S Thomas

  61. Formaldehyde: Integrating Dosimetry, Cytotoxicity, and Genomics to Understand Dose-Dependent Transitions for an Endogenous Compound

    Article • Toxicological Sciences, September 2010, Oxford University Press (OUP)

    Dr Russell S Thomas

  62. An Integrated Genomic Analysis of Aryl Hydrocarbon Receptor-Mediated Inhibition of B-Cell Differentiation

    Article • Toxicological Sciences, September 2010, Oxford University Press (OUP)

    Dr Russell S Thomas

  63. Functional analysis of multiple genomic signatures demonstrates that classification algorithms choose phenotype-related genes

    Article • The Pharmacogenomics Journal, August 2010, Nature

    Dr Russell S Thomas

  64. A comparison of batch effect removal methods for enhancement of prediction performance using MAQC-II microarray gene expression data

    Article • The Pharmacogenomics Journal, August 2010, Nature

    Dr Russell S Thomas

  65. The MicroArray Quality Control (MAQC)-II study of common practices for the development and validation of microarray-based predictive models

    Article • Nature Biotechnology, July 2010, Nature

    Dr Richard S Judson, Dr Russell S Thomas

  66. The Identification of Protein Kinase C Iota as a Regulator of the Mammalian Heat Shock Response Using Functional Genomic Screens

    Article • PLoS ONE, July 2010, PLOS

    Dr Russell S Thomas

  67. Genome-wide Analysis of DNA Methylation and Gene Expression Changes in the Mouse Lung following Subchronic Arsenate Exposure

    Article • Toxicological Sciences, July 2010, Oxford University Press (OUP)

    Dr Russell S Thomas

  68. Incorporating Human Dosimetry and Exposure into High-Throughput In Vitro Toxicity Screening

    Article • Toxicological Sciences, July 2010, Oxford University Press (OUP)

    Dr Richard S Judson, Dr John Fredrick Wambaugh, Dr Russell S Thomas

  69. Quantitative analyses and transcriptomic profiling of circulating messenger RNAs as biomarkers of rat liver injury

    Article • Hepatology, February 2010, Wiley

    Dr Russell S Thomas

  70. Activation of the Aryl-Hydrocarbon Receptor Inhibits Invasive and Metastatic Features of Human Breast Cancer Cells and Promotes Breast Cancer Cell Differentiation

    Article • Molecular Endocrinology, February 2010, Endocrine Society

    Dr Russell S Thomas

  71. A Bistable Switch Underlying B-Cell Differentiation and Its Disruption by the Environmental Contaminant 2,3,7,8-Tetrachlorodibenzo-p-dioxin

    Article • Toxicological Sciences, February 2010, Oxford University Press (OUP)

    Dr Russell S Thomas

  72. Expression profiling in canine osteosarcoma: identification of biomarkers and pathways associated with outcome

    Article • BMC Cancer, January 2010, Springer Science + Business Media

    Dr Russell S Thomas

  73. Stochastic Modeling of B Lymphocyte Terminal Differentiation and Its Suppression by Dioxin

    Article • BMC Systems Biology, January 2010, Springer Science + Business Media

    Dr Russell S Thomas

  74. Regulation of Aryl Hydrocarbon Receptor Function by Selective Estrogen Receptor Modulators

    Article • Molecular Endocrinology, January 2010, Endocrine Society

    Dr Russell S Thomas

  75. Aryl Hydrocarbon Receptor Regulates Cell Cycle Progression in Human Breast Cancer Cells via a Functional Interaction with Cyclin-Dependent Kinase 4

    Article • Molecular Pharmacology, November 2009, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Dr Russell S Thomas

  76. Use of Short-term Transcriptional Profiles to Assess the Long-term Cancer-Related Safety of Environmental and Industrial Chemicals

    Article • Toxicological Sciences, September 2009, Oxford University Press (OUP)

    Dr Russell S Thomas

  77. Dose-dependent transitions in Nrf2-mediated adaptive response and related stress responses to hypochlorous acid in mouse macrophages

    Article • Toxicology and Applied Pharmacology, July 2009, Elsevier

    Dr Russell S Thomas

  78. In utero exposure to chloroquine alters sexual development in the male fetal rat

    Article • Toxicology and Applied Pharmacology, June 2009, Elsevier

    Dr Russell S Thomas

  79. Gene Expression Changes Following Acute Hydrogen Sulfide (H2S)-induced Nasal Respiratory Epithelial Injury

    Article • Toxicologic Pathology, May 2008, SAGE Publications

    Dr Russell S Thomas

  80. Genomic Signatures and Dose-Dependent Transitions in Nasal Epithelial Responses to Inhaled Formaldehyde in the Rat

    Article • Toxicological Sciences, February 2008, Oxford University Press (OUP)

    Dr Russell S Thomas

  81. Research toward the development of a biologically based dose response assessment for inorganic arsenic carcinogenicity: A progress report

    Article • Toxicology and Applied Pharmacology, August 2007, Elsevier

    Dr Russell S Thomas

  82. Application of Genomic Biomarkers to Predict Increased Lung Tumor Incidence in 2-Year Rodent Cancer Bioassays

    Article • Toxicological Sciences, May 2007, Oxford University Press (OUP)

    Dr Russell S Thomas

  83. A Method to Integrate Benchmark Dose Estimates with Genomic Data to Assess the Functional Effects of Chemical Exposure

    Article • Toxicological Sciences, April 2007, Oxford University Press (OUP)

    Dr Russell S Thomas

  84. Biologically Motivated Approaches to Extrapolation from High to Low Doses and the Advent of Systems Biology: The Road to Toxicological Safety Assessment

    Article • Human and Ecological Risk Assessment An International Journal, March 2007, Taylor & Francis

    Dr Russell S Thomas

  85. Genomic analysis of human lung fibroblasts exposed to vanadium pentoxide to identify candidate genes for occupational bronchitis

    Article • BMJ Open Respiratory Research, January 2007, Springer Science + Business Media

    Dr Russell S Thomas

  86. BMDExpress: a software tool for the benchmark dose analyses of genomic data

    Article • BMC Genomics, January 2007, Springer Science + Business Media

    Dr Russell S Thomas

  87. Basal Gene Expression in Male and Female Sprague-Dawley Rat Nasal Respiratory and Olfactory Epithelium

    Article • Inhalation Toxicology, January 2007, Taylor & Francis

    Dr Russell S Thomas

  88. A functional map of NFκB signaling identifies novel modulators and multiple system controls

    Article • Genome Biology, January 2007, Springer Science + Business Media

    Dr Russell S Thomas

  89. A Comparison of Transcriptomic and Metabonomic Technologies for Identifying Biomarkers Predictive of Two-Year Rodent Cancer Bioassays

    Article • Toxicological Sciences, November 2006, Oxford University Press (OUP)

    Dr Russell S Thomas

  90. Genome-wide analysis of human HSF1 signaling reveals a transcriptional program linked to cellular adaptation and survival

    Article • Molecular BioSystems, January 2006, Royal Society of Chemistry

    Dr Russell S Thomas

  91. New directions in incidence–dose modeling

    Article • Trends in Biotechnology, March 2005, Elsevier

    Dr Russell S Thomas

  92. EDGE: A Centralized Resource for the Comparison, Analysis, and Distribution of Toxicogenomic Information

    Article • Molecular Pharmacology, January 2005, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Dr Russell S Thomas

  93. Dose–response modeling in reproductive toxicology in the systems biology era

    Article • Reproductive Toxicology, January 2005, Elsevier

    Dr Russell S Thomas

  94. Chemical mixture toxicology: from descriptive to mechanistic, and going on to in silico toxicology

    Article • Environmental Toxicology and Pharmacology, November 2004, Elsevier

    Dr Russell S Thomas

  95. Genome-scale functional profiling of the mammalian AP-1 signaling pathway

    Article • Proceedings of the National Academy of Sciences, September 2003, Proceedings of the National Academy of Sciences

    Dr Russell S Thomas

  96. Stochastic Simulation of Hepatic Preneoplastic Foci Development for Four Chlorobenzene Congeners in a Medium-Term Bioassay

    Article • Toxicological Sciences, April 2003, Oxford University Press (OUP)

    Dr Russell S Thomas

  97. Sequence variation and phylogenetic history of the mouse Ahr gene

    Article • Pharmacogenetics, March 2002, Wolters Kluwer Health

    Dr Russell S Thomas

  98. Developing toxicologically predictive gene sets using cDNA microarrays and bayesian classification

    Article • January 2002, Elsevier

    Dr Russell S Thomas

  99. The Sequence of the Human Genome

    Article • Science, February 2001, American Association for the Advancement of Science

    Dr Russell S Thomas

  100. A Physiologically Based Pharmacodynamic Analysis of Hepatic Foci within a Medium-Term Liver Bioassay Using Pentachlorobenzene as a Promoter and Diethylnitrosamine as an Initiator

    Article • Toxicology and Applied Pharmacology, July 2000, Elsevier

    Dr Russell S Thomas

  101. Evidence for hepatocarcinogenic activity of pentachlorobenzene with intralobular variation in foci incidence

    Article • Carcinogenesis, October 1998, Oxford University Press (OUP)

    Dr Russell S Thomas

  102. Use of a medium-term liver focus bioassay to assess the hepatocarcinogenicity of 1,2,4,5-tetrachlorobenzene and 1,4-dichlorobenzene

    Article • Cancer Letters, July 1998, Elsevier

    Dr Russell S Thomas

  103. Enhanced Regional Expression of GlutathioneS-Transferase P1-1 with Colocalized AP-1 and CYP 1A2 Induction in Chlorobenzene-Induced Porphyria

    Article • Toxicology and Applied Pharmacology, May 1998, Elsevier

    Dr Russell S Thomas

  104. Physiologically based pharmacokinetic/pharmacodynamic modeling of the toxicologic interaction between carbon tetrachloride and Kepone

    Article • Archives of Toxicology, September 1996, Springer Science + Business Media

    Dr Russell S Thomas

  105. Incorporating Monte Carlo Simulation into Physiologically Based Pharmacokinetic Models Using Advanced Continuous Simulation Language (ACSL): A Computational Method

    Article • Fundamental and Applied Toxicology, May 1996, Elsevier

    Dr Russell S Thomas

  106. The use of physiologically-based pharmacokinetic/ pharmacodynamic dosimetry models for chemical mixtures

    Article • Toxicology Letters, December 1995, Elsevier

    Dr Russell S Thomas

  107. Physiologically based pharmacokinetic/pharmacodynamic modeling of chemical mixtures and possible applications in risk assessment

    Article • Toxicology, December 1995, Elsevier

    Dr Russell S Thomas

  108. The application of physiologically based pharmacokinetic/ pharmacodynamic (PBPK/PD) modeling for exploring risk assessment approaches of chemical mixtures

    Article • Toxicology Letters, September 1995, Elsevier

    Dr Russell S Thomas