All Stories

  1. Predictive models for acute oral systemic toxicity: A workshop to bridge the gap from research to regulation

    Article • Computational Toxicology, November 2018, Elsevier

    Dr Nicole Kleinstreuer

  2. Evaluation of androgen assay results using a curated Hershberger database

    Article • Reproductive Toxicology, September 2018, Elsevier

    Dr Richard S Judson, Dr Nicole Kleinstreuer

  3. International regulatory requirements for skin sensitization testing

    Article • Regulatory Toxicology and Pharmacology, June 2018, Elsevier

    Dr Nicole Kleinstreuer

  4. Status of acute systemic toxicity testing requirements and data uses by U.S. regulatory agencies

    Article • Regulatory Toxicology and Pharmacology, April 2018, Elsevier

    Dr Nicole Kleinstreuer

  5. In vitro to in vivo extrapolation for high throughput prioritization and decision making

    Article • Toxicology in Vitro, March 2018, Elsevier

    Dr John Fredrick Wambaugh, Dr Nicole Kleinstreuer

  6. Non-animal methods to predict skin sensitization (I): the Cosmetics Europe database

    Article • Critical Reviews in Toxicology, February 2018, Taylor & Francis

    Dr Nicole Kleinstreuer

  7. Non-animal methods to predict skin sensitization (II): an assessment of defined approaches

    Article • Critical Reviews in Toxicology, February 2018, Taylor & Francis

    Dr Nicole Kleinstreuer

  8. Highlight report: ‘Big data in the 3R’s: outlook and recommendations’, a roundtable summary

    Article • Archives of Toxicology, January 2018, Springer Science + Business Media

    Dr Nicole Kleinstreuer

  9. Integrated decision strategies for skin sensitization hazard

    Article • Journal of Applied Toxicology, November 2017, Wiley

    Dr Nicole Kleinstreuer

  10. Standardisation of defined approaches for skin sensitisation testing to support regulatory use and international adoption: position of the International Cooperation on Alternative Test Methods

    Article • Archives of Toxicology, November 2017, Springer Science + Business Media

    Dr Nicole Kleinstreuer

  11. Embryonic vascular disruption adverse outcomes: Linking high throughput signaling signatures with functional consequences

    Article • Reproductive Toxicology, August 2017, Elsevier

    Dr Nicole Kleinstreuer

  12. Embryonic vascular disruption adverse outcomes: Linking high throughput signaling signatures with functional consequences

    Article • Reproductive Toxicology, June 2017, Elsevier

    Dr Nicole Kleinstreuer

  13. Identifying environmental chemicals as agonists of the androgen receptor by using a quantitative high-throughput screening platform

    Article • Toxicology, June 2017, Elsevier

    Dr Nicole Kleinstreuer

  14. An Integrated Chemical Environment to Support 21st-Century Toxicology

    Article • Environmental Health Perspectives, May 2017, Environmental Health Perspectives

    Dr Nicole Kleinstreuer

  15. Pred-Skin: A Fast and Reliable Web Application to Assess Skin Sensitization Effect of Chemicals

    Article • Journal of Chemical Information and Computer Sciences, May 2017, American Chemical Society (ACS)

    Dr Carolina Horta Andrade, Dr Nicole Kleinstreuer

  16. Prediction of skin sensitization potency using machine learning approaches

    Article • Journal of Applied Toxicology, January 2017, Wiley

    Dr Nicole Kleinstreuer

  17. Machine Learning Approaches to Predict PhysChem Properties of Environmental Chemicals

    Article • Journal of Chemical Information and Computer Sciences, December 2016, American Chemical Society (ACS)

    Dr Antony John Williams, Dr Nicole Kleinstreuer, Dr kamel mansouri

  18. Screening for angiogenic inhibitors in zebrafish to evaluate a predictive model for developmental vascular toxicity

    Article • Reproductive Toxicology, December 2016, Elsevier

    Dr Nicole Kleinstreuer, Maria Bondesson

  19. Development and Validation of a Computational Model for Androgen Receptor Activity

    Article • Chemical Research in Toxicology, November 2016, American Chemical Society (ACS)

    Dr Nicole Kleinstreuer, Dr Eric Dean Watt

  20. Identification of vascular disruptor compounds by analysis in zebrafish embryos and mouse embryonic endothelial cells

    Article • Reproductive Toxicology, November 2016, Elsevier

    Dr Nicole Kleinstreuer, Maria Bondesson

  21. Analysis of the Effects of Cell Stress and Cytotoxicity onIn VitroAssay Activity Across a Diverse Chemical and Assay Space

    Article • Toxicological Sciences, September 2016, Oxford University Press (OUP)

    Dr Nicole Kleinstreuer, Dr John Fredrick Wambaugh

  22. Low-Dose Mixture Hypothesis of Carcinogenesis Workshop: Scientific Underpinnings and Research Recommendations

    Article • Environmental Health Perspectives, August 2016, Environmental Health Perspectives

    Dr Nicole Kleinstreuer

  23. Multivariate models for prediction of human skin sensitization hazard

    Article • Journal of Applied Toxicology, August 2016, Wiley

    Dr Nicole Kleinstreuer

  24. Editor's Highlight: Analysis of the Effects of Cell Stress and Cytotoxicity onIn VitroAssay Activity Across a Diverse Chemical and Assay Space

    Article • Toxicological Sciences, May 2016, Oxford University Press (OUP)

    Dr Kevin M Crofton, Dr John Fredrick Wambaugh, Dr Nicole Kleinstreuer

  25. Integration of Life-Stage Physiologically Based Pharmacokinetic Models with Adverse Outcome Pathways and Environmental Exposure Models to Screen for Environmental Hazards

    Article • Toxicological Sciences, May 2016, Oxford University Press (OUP)

    Dr Tamara Tal, Dr Nicole Kleinstreuer, Ronald N. Hines

  26. Adverse outcome pathways: From research to regulation scientific workshop report

    Article • Regulatory Toxicology and Pharmacology, April 2016, Elsevier

    Dr Nicole Kleinstreuer

  27. Integrated decision strategies for skin sensitization hazard

    Article • Journal of Applied Toxicology, February 2016, Wiley

    Dr Nicole Kleinstreuer

  28. QSAR models of human data can enrich or replace LLNA testing for human skin sensitization

    Article • Green Chemistry, January 2016, Royal Society of Chemistry

    Dr Nicole Kleinstreuer

  29. Toward Good Read-Across Practice (GRAP) guidance

    Article • ALTEX, January 2016, ALTEX Edition

    Dr Nicole Kleinstreuer

  30. Supporting read-across using biological data

    Article • ALTEX, January 2016, ALTEX Edition

    Dr Nicole Kleinstreuer

  31. A Curated Database of Rodent Uterotrophic Bioactivity

    Article • Environmental Health Perspectives, October 2015, Environmental Health Perspectives

    Dr Nicole Kleinstreuer

  32. Screening Chemicals for Estrogen Receptor Bioactivity Using a Computational Model

    Article • Environmental Science & Technology, July 2015, American Chemical Society (ACS)

    Dr Richard S Judson, Dr Russell S Thomas, Dr Nicole Kleinstreuer

  33. Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: the challenge ahead

    Article • Carcinogenesis, June 2015, Oxford University Press (OUP)

    Dr Chiara Mondello, Dr Nicole Kleinstreuer, Dr GRAEME P WILLIAMS, Dr VALERIAN DORMOY, Professor Po Sing Leung, Colleen Curran, Laura Soucek

  34. Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: focus on the cancer hallmark of tumor angiogenesis

    Article • Carcinogenesis, June 2015, Oxford University Press (OUP)

    Dr Chiara Mondello, Dr Nicole Kleinstreuer, Dr VALERIAN DORMOY

  35. Predicting chemically-induced skin reactions. Part II: QSAR models of skin permeability and the relationships between skin permeability and skin sensitization

    Article • Toxicology and Applied Pharmacology, April 2015, Elsevier

    Dr Nicole Kleinstreuer

  36. Predicting chemically-induced skin reactions. Part I: QSAR models of skin sensitization and their application to identify potentially hazardous compounds

    Article • Toxicology and Applied Pharmacology, April 2015, Elsevier

    Dr Nicole Kleinstreuer

  37. A Vision of Toxicity Testing in the 21st Century

    Article • Applied In Vitro Toxicology, March 2015, Mary Ann Liebert Inc

    Dr Nicole Kleinstreuer

  38. Application of Reverse Dosimetry to Compare In Vitro and In Vivo Estrogen Receptor Activity

    Article • Applied In Vitro Toxicology, March 2015, Mary Ann Liebert Inc

    Dr Nicole Kleinstreuer

  39. Immediate and long-term consequences of vascular toxicity during zebrafish development

    Article • Reproductive Toxicology, September 2014, Elsevier

    Dr Nicole Kleinstreuer, Maria Bondesson

  40. Phenotypic screening of the ToxCast chemical library to classify toxic and therapeutic mechanisms

    Article • Nature Biotechnology, May 2014, Springer Science + Business Media

    Dr Ellen L Berg, Dr Richard S Judson, Dr Keith Houck, Dr Nicole Kleinstreuer

  41. Integrated Testing Strategies (ITS) for safety assessment

    Article • ALTEX, January 2014, ALTEX Edition

    Dr Nicole Kleinstreuer

  42. Open source software implementation of an integrated testing strategy for skin sensitization potency based on a Bayesian network

    Article • ALTEX, January 2014, ALTEX Edition

    Dr Nicole Kleinstreuer

  43. Dosimetric Anchoring of In Vivo and In Vitro Studies for Perfluorooctanoate and Perfluorooctanesulfonate

    Article • Toxicological Sciences, September 2013, Oxford University Press (OUP)

    Dr Richard S Judson, Dr John Fredrick Wambaugh, Dr Nicole Kleinstreuer

  44. A C. elegans Screening Platform for the Rapid Assessment of Chemical Disruption of Germline Function

    Article • Environmental Health Perspectives, April 2013, Environmental Health Perspectives

    Dr Patrick Allard, Dr Nicole Kleinstreuer

  45. A Computational Model Predicting Disruption of Blood Vessel Development

    Article • PLoS Computational Biology, April 2013, PLOS

    Dr Nicole Kleinstreuer

  46. Predictive Models and Computational Toxicology

    Article • October 2012, Springer Science + Business Media

    Dr Nicole Kleinstreuer

  47. In Vitro Perturbations of Targets in Cancer Hallmark Processes Predict Rodent Chemical Carcinogenesis

    Article • Toxicological Sciences, September 2012, Oxford University Press (OUP)

    Dr Richard S Judson, Dr Kevin M Crofton, Dr Nicole Kleinstreuer

  48. Incorporating Biological, Chemical, and Toxicological Knowledge Into Predictive Models of Toxicity

    Article • Toxicological Sciences, September 2012, Oxford University Press (OUP)

    Dr Richard S Judson, Dr Nicole Kleinstreuer

  49. Computational toxicology and in silico modeling of embryogenesis

    Article • Reproductive Toxicology, September 2012, Elsevier

    Dr Tamara Tal, Dr Nicole Kleinstreuer

  50. Update on EPA’s ToxCast Program: Providing High Throughput Decision Support Tools for Chemical Risk Management

    Article • Chemical Research in Toxicology, July 2012, American Chemical Society (ACS)

    Dr Richard S Judson, Dr Keith Houck, Dr Nicole Kleinstreuer

  51. Zebrafish developmental screening of the ToxCast™ Phase I chemical library

    Article • Reproductive Toxicology, April 2012, Elsevier

    Dr Keith Houck, Dr Nicole Kleinstreuer

  52. Predictive modeling and computational toxicology

    Article • December 2011, Informa Healthcare

    Dr Nicole Kleinstreuer

  53. Disruption of embryonic vascular development in predictive toxicology

    Article • Birth Defects Research Part C Embryo Today Reviews, December 2011, Wiley

    Dr Nicole Kleinstreuer

  54. Identifying developmental toxicity pathways for a subset of ToxCast chemicals using human embryonic stem cells and metabolomics

    Article • Toxicology and Applied Pharmacology, November 2011, Elsevier

    Dr Nicole Kleinstreuer

  55. Predictive Models of Prenatal Developmental Toxicity from ToxCast High-Throughput Screening Data

    Article • Toxicological Sciences, August 2011, Oxford University Press (OUP)

    Dr Richard S Judson, Dr Nicole Kleinstreuer

  56. Environmental Impact on Vascular Development Predicted by High-Throughput Screening

    Article • Environmental Health Perspectives, July 2011, Environmental Health Perspectives

    Dr Richard S Judson, Dr Nicole Kleinstreuer

  57. Evaluation of 309 Environmental Chemicals Using a Mouse Embryonic Stem Cell Adherent Cell Differentiation and Cytotoxicity Assay

    Article • PLoS ONE, June 2011, PLOS

    Dr Richard S Judson, Dr Nicole Kleinstreuer

  58. Activity profiles of 309 ToxCast™ chemicals evaluated across 292 biochemical targets

    Article • Toxicology, March 2011, Elsevier

    Dr Richard S Judson, Dr Keith Houck, Dr Nicole Kleinstreuer

  59. Dynamic myogenic autoregulation in the rat kidney: a whole-organ model

    Article • AJP Renal Physiology, April 2008, American Physiological Society

    Dr Nicole Kleinstreuer, Prof Zoltan H Endre