All Stories

  1. Development of a prioritization method for chemical-mediated effects on steroidogenesis using an integrated statistical analysis of high-throughput H295R data

    Article • Regulatory Toxicology and Pharmacology, December 2019, Elsevier

    Dr Richard S Judson

  2. Empirical models for anatomical and physiological changes in a human mother and fetus during pregnancy and gestation

    Article • PLoS ONE, May 2019, PLOS

    Dr Richard S Judson, Dr John Fredrick Wambaugh

  3. Predicting estrogen receptor activation by a group of substituted phenols: An Integrated Approach to testing and assessment case study

    Article • Regulatory Toxicology and Pharmacology, May 2019, Elsevier

    Dr Richard S Judson

  4. Estimating Uncertainty in the Context of New Approach Methodologies for Potential Use in Chemical Safety Evaluation

    Article • Current Opinion in Toxicology, April 2019, Elsevier

    Dr Richard S Judson, Dr John Fredrick Wambaugh

  5. Empirical Models for Anatomical and Physiological Changes in a Human Mother and Fetus During Pregnancy and Gestation

    Article • October 2018, Cold Spring Harbor Laboratory Press

    Dr Richard S Judson, Dr John Fredrick Wambaugh

  6. Integrating data gap filling techniques: A case study predicting TEFs for neurotoxicity TEQs to facilitate the hazard assessment of polychlorinated biphenyls

    Article • Regulatory Toxicology and Pharmacology, October 2018, Elsevier

    Dr Richard S Judson

  7. DEVELOPMENT OF A CURATED HERSHBERGER DATABASE

    Article • Reproductive Toxicology, September 2018, Elsevier

    Dr Richard S Judson

  8. Evaluation of androgen assay results using a curated Hershberger database

    Article • Reproductive Toxicology, September 2018, Elsevier

    Dr Richard S Judson, Dr Nicole Kleinstreuer

  9. A Mechanistic Framework for Integrating Chemical Structure and High-Throughput Screening Results to Improve Toxicity Predictions

    Article • Computational Toxicology, August 2018, Elsevier

    Dr Richard S Judson

  10. Uncertainty quantification in ToxCast high throughput screening

    Article • PLoS ONE, July 2018, PLOS

    Dr Eric Dean Watt, Dr Richard S Judson

  11. High-Throughput H295R Steroidogenesis Assay: Utility as an Alternative and a Statistical Approach to Characterize Effects on Steroidogenesis

    Article • Toxicological Sciences, December 2017, Oxford University Press (OUP)

    Dr Richard S Judson

  12. On selecting a minimal set of in vitro assays to reliably determine estrogen agonist activity

    Article • Regulatory Toxicology and Pharmacology, October 2017, Elsevier

    Dr Richard S Judson

  13. Systematically evaluating read-across prediction and performance using a local validity approach characterized by chemical structure and bioactivity information

    Article • Regulatory Toxicology and Pharmacology, August 2016, Elsevier

    Dr Richard S Judson

  14. Screening Chemicals for Estrogen Receptor Bioactivity Using a Computational Model

    Article • Environmental Science & Technology, July 2015, American Chemical Society (ACS)

    Dr Richard S Judson, Dr Nicole Kleinstreuer

  15. Predicting Hepatotoxicity Using ToxCastin VitroBioactivity and Chemical Structure

    Article • Chemical Research in Toxicology, April 2015, American Chemical Society (ACS)

    Dr kamel mansouri, Dr Richard S Judson, Dr Kamel Mansouri, Dr Antony John Williams

  16. Exploring consumer exposure pathways and patterns of use for chemicals in the environment

    Article • Toxicology Reports, January 2015, Elsevier

    Dr Richard S Judson, Dr John Fredrick Wambaugh

  17. Rapid, automated approach to estimate human exposure to over 8,000 environmental chemicals

    Article • Environmental Science & Technology, November 2014, American Chemical Society (ACS)

    Dr Richard S Judson, Dr John Fredrick Wambaugh

  18. Predictive Endocrine Testing in the 21st Century Using in Vitro Assays of Estrogen Receptor Signaling Responses

    Article • Environmental Science & Technology, August 2014, American Chemical Society (ACS)

    Dr Richard S Judson, Dr Keith Houck

  19. Profiling of the Tox21 10K compound library for agonists and antagonists of the estrogen receptor alpha signaling pathway

    Article • Scientific Reports, July 2014, Nature

    Dr Richard S Judson, Dr Keith Houck

  20. Phenotypic screening of the ToxCast chemical library to classify toxic and therapeutic mechanisms

    Article • Nature Biotechnology, May 2014, Springer Science + Business Media

    Dr Ellen L Berg, Dr Richard S Judson, Dr Keith Houck, Dr Nicole Kleinstreuer

  21. In Vitroand Modelling Approaches to Risk Assessment from the U.S. Environmental Protection Agency ToxCast Programme

    Article • Basic & Clinical Pharmacology & Toxicology, April 2014, Wiley

    Dr Richard S Judson, Dr Keith Houck, Dr John Fredrick Wambaugh, Dr Kevin M Crofton

  22. Development of a consumer product ingredient database for chemical exposure screening and prioritization

    Article • Food and Chemical Toxicology, March 2014, Elsevier

    Dr Richard S Judson, Dr John Fredrick Wambaugh

  23. Erratum

    Article • Toxicological Sciences, January 2014, Oxford University Press (OUP)

    Dr Richard S Judson, Dr John Fredrick Wambaugh

  24. Binary Classification of a Large Collection of Environmental Chemicals from Estrogen Receptor Assays by Quantitative Structure–Activity Relationship and Machine Learning Methods

    Article • Journal of Chemical Information and Modeling, December 2013, American Chemical Society (ACS)

    Dr Richard S Judson

  25. Dosimetric Anchoring of In Vivo and In Vitro Studies for Perfluorooctanoate and Perfluorooctanesulfonate

    Article • Toxicological Sciences, September 2013, Oxford University Press (OUP)

    Dr Richard S Judson, Dr John Fredrick Wambaugh, Dr Nicole Kleinstreuer

  26. EADB: An Estrogenic Activity Database for Assessing Potential Endocrine Activity

    Article • Toxicological Sciences, July 2013, Oxford University Press (OUP)

    Dr Richard S Judson

  27. Real-Time Growth Kinetics Measuring Hormone Mimicry for ToxCast Chemicals in T-47D Human Ductal Carcinoma Cells

    Article • Chemical Research in Toxicology, July 2013, American Chemical Society (ACS)

    Dr Richard S Judson, Dr Keith Houck

  28. High-Throughput Models for Exposure-Based Chemical Prioritization in the ExpoCast Project

    Article • Environmental Science & Technology, July 2013, American Chemical Society (ACS)

    Dr Richard S Judson, Dr John Fredrick Wambaugh

  29. Profiling 976 ToxCast Chemicals across 331 Enzymatic and Receptor Signaling Assays

    Article • Chemical Research in Toxicology, June 2013, American Chemical Society (ACS)

    Dr Richard S Judson, Dr Keith Houck

  30. ToxCast: Predicting Toxicity Potential Through High-Throughput Bioactivity Profiling

    Article • March 2013, Wiley

    Dr Richard S Judson, Dr Keith Houck

  31. Relative Impact of Incorporating Pharmacokinetics on Predicting In Vivo Hazard and Mode of Action from High-Throughput In Vitro Toxicity Assays

    Article • Toxicological Sciences, January 2013, Oxford University Press (OUP)

    Dr Richard S Judson, Dr John Fredrick Wambaugh

  32. ToxPi GUI: an interactive visualization tool for transparent integration of data from diverse sources of evidence

    Article • Bioinformatics, November 2012, Oxford University Press (OUP)

    Dr Richard S Judson

  33. Incorporating exposure information into the toxicological prioritization index decision support framework

    Article • The Science of The Total Environment, October 2012, Elsevier

    Dr Richard S Judson, Dr John Fredrick Wambaugh

  34. Using in Vitro High Throughput Screening Assays to Identify Potential Endocrine-Disrupting Chemicals

    Article • Environmental Health Perspectives, September 2012, Environmental Health Perspectives

    Dr Richard S Judson, Dr Kevin M Crofton

  35. In Vitro Perturbations of Targets in Cancer Hallmark Processes Predict Rodent Chemical Carcinogenesis

    Article • Toxicological Sciences, September 2012, Oxford University Press (OUP)

    Dr Richard S Judson, Dr Kevin M Crofton, Dr Nicole Kleinstreuer

  36. Incorporating Biological, Chemical, and Toxicological Knowledge Into Predictive Models of Toxicity

    Article • Toxicological Sciences, September 2012, Oxford University Press (OUP)

    Dr Richard S Judson, Dr Nicole Kleinstreuer

  37. Update on EPA’s ToxCast Program: Providing High Throughput Decision Support Tools for Chemical Risk Management

    Article • Chemical Research in Toxicology, July 2012, American Chemical Society (ACS)

    Dr Richard S Judson, Dr Keith Houck, Dr Nicole Kleinstreuer

  38. Response to "Accurate Risk-Based Chemical Screening * Relies on Robust Exposure Estimates"

    Article • Toxicological Sciences, April 2012, Oxford University Press (OUP)

    Dr Richard S Judson, Dr John Fredrick Wambaugh

  39. Aggregating Data for Computational Toxicology Applications: The U.S. Environmental Protection Agency (EPA) Aggregated Computational Toxicology Resource (ACToR) System

    Article • International Journal of Molecular Sciences, February 2012, MDPI AG

    Dr Richard S Judson

  40. Economic benefits of using adaptive predictive models of reproductive toxicity in the context of a tiered testing program

    Article • Systems Biology in Reproductive Medicine, January 2012, Taylor & Francis

    Dr Richard S Judson

  41. The exposure data landscape for manufactured chemicals

    Article • The Science of The Total Environment, January 2012, Elsevier

    Dr Richard S Judson

  42. Using pathway modules as targets for assay development in xenobiotic screening

    Article • Molecular BioSystems, January 2012, Royal Society of Chemistry

    Dr Richard S Judson

  43. Modeling In Vitro Cell-Based Assays Experiments

    Article • January 2012, Elsevier

    Dr Richard S Judson, Dr John Fredrick Wambaugh

  44. Integration of Dosimetry, Exposure, and High-Throughput Screening Data in Chemical Toxicity Assessment

    Article • Toxicological Sciences, September 2011, Oxford University Press (OUP)

    Dr Richard S Judson, Dr John Fredrick Wambaugh

  45. Predictive Models of Prenatal Developmental Toxicity from ToxCast High-Throughput Screening Data

    Article • Toxicological Sciences, August 2011, Oxford University Press (OUP)

    Dr Richard S Judson, Dr Nicole Kleinstreuer

  46. Environmental Impact on Vascular Development Predicted by High-Throughput Screening

    Article • Environmental Health Perspectives, July 2011, Environmental Health Perspectives

    Dr Richard S Judson, Dr Nicole Kleinstreuer

  47. Evaluation of 309 Environmental Chemicals Using a Mouse Embryonic Stem Cell Adherent Cell Differentiation and Cytotoxicity Assay

    Article • PLoS ONE, June 2011, PLOS

    Dr Richard S Judson, Dr Nicole Kleinstreuer

  48. Predictive Model of Rat Reproductive Toxicity from ToxCast High Throughput Screening

    Article • Biology of Reproduction, May 2011, Society for the Study of Reproduction

    Dr Richard S Judson, Dr Keith Houck

  49. Chemical Genomics Profiling of Environmental Chemical Modulation of Human Nuclear Receptors

    Article • Environmental Health Perspectives, May 2011, Environmental Health Perspectives

    Dr Richard S Judson, Dr Keith Houck

  50. Estimating Toxicity-Related Biological Pathway Altering Doses for High-Throughput Chemical Risk Assessment

    Article • Chemical Research in Toxicology, April 2011, American Chemical Society (ACS)

    Dr Richard S Judson, Dr Keith Houck

  51. Activity profiles of 309 ToxCast™ chemicals evaluated across 292 biochemical targets

    Article • Toxicology, March 2011, Elsevier

    Dr Richard S Judson, Dr Keith Houck, Dr Nicole Kleinstreuer

  52. Using Nuclear Receptor Activity to Stratify Hepatocarcinogens

    Article • PLoS ONE, February 2011, PLOS

    Dr Richard S Judson, Dr Keith Houck, Dr John Fredrick Wambaugh

  53. Endocrine Profiling and Prioritization of Environmental Chemicals Using ToxCast Data

    Article • Environmental Health Perspectives, September 2010, Environmental Health Perspectives

    Dr Richard S Judson, Dr Keith Houck

  54. A Novel Framework for Predicting In Vivo Toxicities from In Vitro Data Using Optimal Methods for Dense and Sparse Matrix Reordering and Logistic Regression

    Article • Toxicological Sciences, August 2010, Oxford University Press (OUP)

    Dr Richard S Judson

  55. Analysis of Eight Oil Spill Dispersants Using Rapid, In Vitro Tests for Endocrine and Other Biological Activity

    Article • Environmental Science & Technology, August 2010, American Chemical Society (ACS)

    Dr Richard S Judson, Dr Keith Houck

  56. The MicroArray Quality Control (MAQC)-II study of common practices for the development and validation of microarray-based predictive models

    Article • Nature Biotechnology, July 2010, Nature

    Dr Richard S Judson

  57. Incorporating Human Dosimetry and Exposure into High-Throughput In Vitro Toxicity Screening

    Article • Toxicological Sciences, July 2010, Oxford University Press (OUP)

    Dr Richard S Judson, Dr John Fredrick Wambaugh

  58. Xenobiotic-Metabolizing Enzyme and Transporter Gene Expression in Primary Cultures of Human Hepatocytes Modulated by Toxcast Chemicals

    Article • Journal of Toxicology and Environmental Health Part B, June 2010, Taylor & Francis

    Dr Richard S Judson, Dr Keith Houck

  59. Public Databases Supporting Computational Toxicology

    Article • Journal of Toxicology and Environmental Health Part B, June 2010, Taylor & Francis

    Dr Richard S Judson

  60. Impact of Environmental Chemicals on Key Transcription Regulators and Correlation to Toxicity End Points within EPA’s ToxCast Program

    Article • Chemical Research in Toxicology, March 2010, American Chemical Society (ACS)

    Dr Richard S Judson, Dr Keith Houck

  61. In Vitro Screening of Environmental Chemicals for Targeted Testing Prioritization: The ToxCast Project

    Article • Environmental Health Perspectives, December 2009, Environmental Health Perspectives

    Dr Richard S Judson, Dr Keith Houck

  62. Evaluation of high-throughput genotoxicity assays used in profiling the US EPA ToxCast™ chemicals

    Article • Regulatory Toxicology and Pharmacology, November 2009, Elsevier

    Dr Richard S Judson, Dr Keith Houck

  63. Profiling the activity of environmental chemicals in prenatal developmental toxicity studies using the U.S. EPA's ToxRefDB

    Article • Reproductive Toxicology, September 2009, Elsevier

    Dr Richard S Judson

  64. Profiling the Reproductive Toxicity of Chemicals from Multigeneration Studies in the Toxicity Reference Database

    Article • Toxicological Sciences, April 2009, Oxford University Press (OUP)

    Dr Richard S Judson

  65. The Toxicity Data Landscape for Environmental Chemicals

    Article • Environmental Health Perspectives, December 2008, Environmental Health Perspectives

    Dr Richard S Judson, Dr Keith Houck

  66. ACToR — Aggregated Computational Toxicology Resource

    Article • Toxicology and Applied Pharmacology, November 2008, Elsevier

    Dr Richard S Judson, Dr Keith Houck

  67. Profiling Chemicals Based on Chronic Toxicity Results from the U.S. EPA ToxRef Database

    Article • Environmental Health Perspectives, October 2008, Environmental Health Perspectives

    Dr Richard S Judson

  68. Bayesian Meta-Analysis of Genetic Association Studies with Different Sets of Markers

    Article • The American Journal of Human Genetics, April 2008, Elsevier

    Dr Richard S Judson

  69. Toxicity Data Informatics: Supporting a New Paradigm for Toxicity Prediction

    Article • Toxicology Mechanisms and Methods, January 2008, Taylor & Francis

    Dr Richard S Judson

  70. A comparison of machine learning algorithms for chemical toxicity classification using a simulated multi-scale data model

    Article • BMC Bioinformatics, January 2008, Springer Science + Business Media

    Dr Richard S Judson

  71. Computational Toxicology--A State of the Science Mini Review

    Article • Toxicological Sciences, December 2007, Oxford University Press (OUP)

    Dr Richard S Judson

  72. Allelic dropout in long QT syndrome genetic testing: A possible mechanism underlying false-negative results

    Article • Heart Rhythm, July 2006, Elsevier

    Dr Richard S Judson

  73. Restoring value to stalled Phase II compounds: the case for developing a novel compound for depression using pharmacogenetics

    Article • Pharmacogenomics, March 2005, Future Medicine

    Dr Richard S Judson

  74. New and confirmatory evidence of an association between APOE genotype and baseline C-reactive protein in dyslipidemic individuals

    Article • Atherosclerosis, December 2004, Elsevier

    Dr Richard S Judson

  75. Spectrum and prevalence of cardiac sodium channel variants among black, white, Asian, and Hispanic individuals: Implications for arrhythmogenic susceptibility and Brugada/long QT syndrome genetic testing

    Article • Heart Rhythm, November 2004, Elsevier

    Dr Richard S Judson

  76. Genome-wide evaluation of the public SNP databases

    Article • Pharmacogenomics, November 2003, Future Medicine

    Dr Richard S Judson

  77. Using Multiple Drug Exposure Levels to Optimize Power in Pharmacogenetic Trials

    Article • The Journal of Clinical Pharmacology, August 2003, Wiley

    Dr Richard S Judson

  78. Haplotypes of the cholesteryl ester transfer protein gene predict lipid-modifying response to statin therapy

    Article • The Pharmacogenomics Journal, January 2003, Nature

    Dr Richard S Judson

  79. How many SNPs does a genome-wide haplotype map require?

    Article • Pharmacogenomics, May 2002, Future Medicine

    Dr Richard S Judson

  80. Haplotype Variation and Linkage Disequilibrium in 313 Human Genes

    Article • Science, July 2001, American Association for the Advancement of Science

    Dr Richard S Judson

  81. Notes from the SNP vs. haplotype front

    Article • Pharmacogenomics, February 2001, Future Medicine

    Dr Richard S Judson

  82. Article • Nature, February 2000, Nature

    Dr Richard S Judson, Dr. Peter Uetz

  83. A large-scale experiment to assess protein structure prediction methods

    Article • Proteins Structure Function and Bioinformatics, November 1995, Wiley

    Dr Richard S Judson

  84. A genetic algorithm based method for docking flexible molecules

    Article • Journal of Molecular Structure THEOCHEM, May 1994, Elsevier

    Dr Richard S Judson

  85. Teaching lasers to control molecules

    Article • Physical Review Letters, March 1992, American Physical Society (APS)

    Dr Richard S Judson

  86. Inelastic probabilities above the three-body breakup threshold via a projection operator formalism

    Article • Chemical Physics Letters, June 1991, Elsevier

    Dr Richard S Judson

  87. Reactive scattering using a mixed quantum-classical paradigm

    Article • Chemical Physics Letters, April 1991, Elsevier

    Dr Richard S Judson

  88. Total integral reactive cross sections for F + H2 → HF + H: comparison of converged quantum, quasiclassical trajectory and experimental results

    Article • Chemical Physics Letters, February 1991, Elsevier

    Dr Richard S Judson

  89. The application of time-dependent wavepacket methods to reactive scattering

    Article • Computer Physics Communications, February 1991, Elsevier

    Dr Richard S Judson

  90. Time-dependent wave-packet method for the complete determination of S -matrix elements for reactive molecular collisions in three dimensions

    Article • Physical Review A, July 1990, American Physical Society (APS)

    Dr Richard S Judson

  91. Time-dependent (wavepacket) quantum approach to reactive scattering: Vibrationally resolved reaction probabilities for F+H2→HF+H

    Article • Chemical Physics Letters, June 1990, Elsevier

    Dr Richard S Judson

  92. Optimal design of external fields for controlling molecular motion: application to rotation

    Article • Journal of Molecular Structure, June 1990, Elsevier

    Dr Richard S Judson

  93. Pharmacogenomics in Drug Development and Clinical Research

    Article • Springer Science + Business Media

    Dr Richard S Judson

  94. Pharmacogenomics in Drug Development

    Article • Springer Science + Business Media

    Dr Richard S Judson