All Stories

  1. Development of original metabolically stable apelin-17 analogs with diuretic and cardiovascular effects

    Article • The FASEB Journal, November 2016, Federation of American Societies For Experimental Biology (FASEB)

    Dr Dominique Bonnet, Dr Xavier Iturrioz

  2. Selective Nonpeptidic Fluorescent Ligands for Oxytocin Receptor: Design, Synthesis, and Application to Time-Resolved FRET Binding Assay

    Article • Journal of Medicinal Chemistry, March 2015, American Chemical Society (ACS)

    Dr Dominique Bonnet

  3. Time-Resolved FRET Binding Assay to Investigate Hetero-Oligomer Binding Properties: Proof of Concept with Dopamine D 1 /D 3 Heterodimer

    Article • ACS Chemical Biology, February 2015, American Chemical Society (ACS)

    Dr Dominique Bonnet

  4. Increasing cellular immunogenicity to peptide-based vaccine candidates using a fluorocarbon antigen delivery system

    Article • Vaccine, February 2015, Elsevier

    Dr Dominique Bonnet

  5. Fluorogenic Squaraine Dimers with Polarity-Sensitive Folding As Bright Far-Red Probes for Background-Free Bioimaging

    Article • Journal of the American Chemical Society, January 2015, American Chemical Society (ACS)

    Dr Dominique Bonnet, Professor Yves MELY

  6. Squaraine as a bright, stable and environment-sensitive far-red label for receptor-specific cellular imaging

    Article • Chemical Communications, January 2015, Royal Society of Chemistry

    Dr Dominique Bonnet, Dr Andrey Klymchenko

  7. ChemInform Abstract: Diastereoselective Synthesis of Novel Aza-Diketopiperazines via a Domino Cyclohydrocarbonylation/Addition Process.

    Article • ChemInform, January 2015, Wiley

    Dr Dominique Bonnet

  8. Un neutraligand de la chimiokine CXCL12 inhibe la fibroprolifération dans un modèle de bronchiolite oblitérante après transplantation hétérotopique de trachée chez la souris

    Article • Revue des Maladies Respiratoires, September 2014, Elsevier

    Dr Dominique Bonnet

  9. Structure–Activity Relationship Studies toward the Discovery of Selective Apelin Receptor Agonists

    Article • Journal of Medicinal Chemistry, April 2014, American Chemical Society (ACS)

    Dr Dominique Bonnet, Dr Xavier Iturrioz

  10. Red Fluorescent Turn-On Ligands for Imaging and Quantifying G Protein-Coupled Receptors in Living Cells

    Article • ChemBioChem, January 2014, Wiley

    Dr Dominique Bonnet, Professor Yves MELY

  11. Diastereoselective synthesis of novel aza-diketopiperazines via a domino cyclohydrocarbonylation/addition process

    Article • Chemical Communications, January 2014, Royal Society of Chemistry

    Dr Dominique Bonnet

  12. An Antedrug of the CXCL12 Neutraligand Blocks Experimental Allergic Asthma without Systemic Effect in Mice

    Article • Journal of Biological Chemistry, February 2013, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Dominique Bonnet

  13. Selective Fluorescent Nonpeptidic Antagonists For Vasopressin V 2 GPCR: Application To Ligand Screening and Oligomerization Assays.

    Article • Journal of Medicinal Chemistry, October 2012, American Chemical Society (ACS)

    Dr Dominique Bonnet

  14. 1010 Use of an α5β1 Small Non-peptidic Antagonist to Inhibit Glioblastoma Migration Fostered by Integrin Expression

    Article • European Journal of Cancer, July 2012, Elsevier

    Dr Dominique Bonnet

  15. Combinatorial Aid for Underprivileged Scaffolds: Solution and Solid-phase Strategies for a Rapid and Efficient Access To Novel Aza-diketopiperazines (Aza-DKP)

    Article • ACS Combinatorial Science, May 2012, American Chemical Society (ACS)

    Dr Dominique Bonnet

  16. Fluorescent Derivatives of AC-42 To Probe Bitopic Orthosteric/Allosteric Binding Mechanisms on Muscarinic M1 Receptors

    Article • Journal of Medicinal Chemistry, March 2012, American Chemical Society (ACS)

    Dr Dominique Bonnet

  17. Prodrugs of a CXC Chemokine-12 (CXCL12) Neutraligand Prevent Inflammatory Reactions in an Asthma Model in Vivo

    Article • ACS Medicinal Chemistry Letters, January 2012, American Chemical Society (ACS)

    Dr Dominique Bonnet

  18. Involvement of the TGFβ pathway in the regulation of α5β1 integrins by caveolin-1 in human glioblastoma

    Article • International Journal of Cancer, October 2011, Wiley

    Dr Dominique Bonnet

  19. Homodimerization of the Death-Associated Protein Kinase Catalytic Domain: Development of a New Small Molecule Fluorescent Reporter

    Article • PLoS ONE, November 2010, PLOS

    Dr Dominique Bonnet

  20. The apelin receptor: from ligand discovery to physiological role

    Article • Regulatory Peptides, September 2010, Elsevier

    Dr Dominique Bonnet

  21. ChemInform Abstract: Inhibition of Farnesyl Protein Transferase by New Farnesyl Phosphonate Derivatives of Phenylalanine.

    Article • ChemInform, August 2010, Wiley

    Dr Dominique Bonnet

  22. 511 Caveolin-1, TGFβ/Smad2 and Alpha5 Beta1 integrins connection in human glioblastoma

    Article • European Journal of Cancer Supplements, June 2010, Elsevier

    Dr Dominique Bonnet

  23. 212 The a5β1 integrin is a therapeutic target for human glioblastoma and participates to chemoresistance

    Article • European Journal of Cancer Supplements, June 2010, Elsevier

    Dr Dominique Bonnet

  24. Neutralizing endogenous chemokines with small molecules

    Article • Pharmacology & Therapeutics, April 2010, Elsevier

    Dr Dominique Bonnet

  25. α5β1 integrin antagonists reduce chemotherapy-induced premature senescence and facilitate apoptosis in human glioblastoma cells

    Article • International Journal of Cancer, January 2010, Wiley

    Dr Dominique Bonnet

  26. Identification and pharmacological properties of E339–3D6, the first nonpeptidic apelin receptor agonist

    Article • The FASEB Journal, December 2009, Wiley

    Dr Dominique Bonnet

  27. Biased Agonist Pharmacochaperones of the AVP V2 Receptor May Treat Congenital Nephrogenic Diabetes Insipidus

    Article • Journal of the American Society of Nephrology, September 2009, American Society of Nephrology

    Dr Dominique Bonnet, Frederic JEAN-ALPHONSE

  28. Solid-Phase Fluorescent Labeling of Receptor Ligands by Click Reaction

    Article • Synfacts, September 2008, Thieme Publishing Group

    Dr Dominique Bonnet

  29. Solid‐Phase Organic Tagging Resins for Labeling Biomolecules by 1,3‐Dipolar Cycloaddition: Application to the Synthesis of a Fluorescent Non‐Peptidic Vasopressin Receptor Ligand

    Article • Chemistry - A European Journal, July 2008, Wiley

    Dr Dominique Bonnet

  30. Small Neutralizing Molecules to Inhibit Actions of the Chemokine CXCL12

    Article • Journal of Biological Chemistry, June 2008, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Dominique Bonnet

  31. Solid-Phase Preparation of a Pilot Library Derived from the 2,3,4,5-Tetrahydro-1 H -benzo[b]azepin-5-amine Scaffold

    Article • Journal of Combinatorial Chemistry, May 2007, American Chemical Society (ACS)

    Dr Dominique Bonnet

  32. (Diphenylphosphino)methanethiol

    Article • March 2007, Wiley

    Dr Dominique Bonnet

  33. (Diphenylphosphino)methanethiol

    Article • March 2007, Wiley

    Dr Dominique Bonnet

  34. Convenient Method To Access New 4,4-Dialkoxy- and 4,4-Diaryloxy-diaza- s -indacene Dyes:  Synthesis and Spectroscopic Evaluation

    Article • The Journal of Organic Chemistry, January 2007, American Chemical Society (ACS)

    Dr Dominique Bonnet, Professor Yves MELY

  35. A Rapid and Versatile Method to Label Receptor Ligands Using “Click” Chemistry:  Validation with the Muscarinic M1 Antagonist Pirenzepine

    Article • Bioconjugate Chemistry, November 2006, American Chemical Society (ACS)

    Dr Dominique Bonnet

  36. Use of a fluorescent polarization based high throughput assay to identify new Calmodulin ligands

    Article • Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, November 2006, Elsevier

    Dr Dominique Bonnet

  37. Effect of Glycoamphiphiles on the Solubilization and Dendritic Cell Uptake of a Lipopeptide:  A Preliminary Study

    Article • Molecular Pharmaceutics, October 2005, American Chemical Society (ACS)

    Dr Dominique Bonnet

  38. Efficient preparation of carbohydrate- and related polyol-amphiphiles by hydrazone ligation

    Article • Tetrahedron Letters, April 2004, Elsevier

    Dr Dominique Bonnet

  39. Solid-Phase Functionalization of Peptides by an α-Hydrazinoacetyl Group

    Article • The Journal of Organic Chemistry, August 2003, American Chemical Society (ACS)

    Oleg Melnyk, Dr Dominique Bonnet

  40. Simultaneous Lipidation of a Characterized Peptide Mixture by Chemoselective Ligation

    Article • Bioconjugate Chemistry, February 2003, American Chemical Society (ACS)

    Oleg Melnyk, Dr Dominique Bonnet

  41. Solid-Phase Synthesis of Tetrahydro-β-carbolinehydantoins via the N -Acyliminium Pictet−Spengler Reaction and Cyclative Cleavage

    Article • Journal of Combinatorial Chemistry, November 2002, American Chemical Society (ACS)

    Dr Dominique Bonnet

  42. Synthesis of an amphiphilic aldehyde using as a key step the condensation of a lipophilic glyoxylic acid amide derivative with tris(hydroxymethyl)aminomethane

    Article • Tetrahedron Letters, March 2001, Elsevier

    Oleg Melnyk, Dr Dominique Bonnet

  43. Synthesis by Chemoselective Ligation and Biological Evaluation of Novel Cell-Permeable PKC-ζ Pseudosubstrate Lipopeptides

    Article • Journal of Medicinal Chemistry, January 2001, American Chemical Society (ACS)

    Oleg Melnyk, Dr Dominique Bonnet

  44. Simultaneous Lipidation of a Multi-Epitope Peptide Cocktail by Chemoselective Hydrazone Formation

    Article • January 2001, Springer Science + Business Media

    Oleg Melnyk, Dr Dominique Bonnet

  45. Chemoselective Acylation of Fully Deprotected Hydrazino Acetyl Peptides. Application to the Synthesis of Lipopeptides

    Article • The Journal of Organic Chemistry, December 2000, American Chemical Society (ACS)

    Oleg Melnyk, Dr Dominique Bonnet

  46. A novel lipophilic glyoxylic acid derivative for the lipidation of peptides using salt-free hydrazone ligation

    Article • Tetrahedron Letters, December 2000, Elsevier

    Oleg Melnyk, Dr Dominique Bonnet

  47. Chemoselective acylation of hydrazinopeptides: a novel and mild method for the derivatization of peptides with sensitive fatty acids

    Article • Tetrahedron Letters, January 2000, Elsevier

    Oleg Melnyk, Dr Dominique Bonnet

  48. A novel and mild solid phase hydroperoxydeamination reaction

    Article • Tetrahedron Letters, October 1999, Elsevier

    Oleg Melnyk, Dr Dominique Bonnet

  49. Synthesis of hydrazinopeptides using solid-phase N -electrophilic amination: extension to the Fmoc/tert -butyl strategy and chemistry of the N-N bond in strong acid media

    Article • Journal of Peptide Research, October 1999, Wiley

    Dr Dominique Bonnet

  50. Reactivity of Lys(NH2)-containing peptides toward endopeptidases

    Article • Journal of Peptide Science, August 1999, Wiley

    Dr Dominique Bonnet

  51. Inhibition of farnesyl protein transferase by new farnesyl phosphonate derivatives of phenylalanine

    Article • Bioorganic & Medicinal Chemistry Letters, June 1996, Elsevier

    Dr Dominique Bonnet

  52. A new tartaric acid-based linker for the synthesis of C-terminal peptide α-oxo-aldehydes

    Article • Springer Science + Business Media

    Dr Dominique Bonnet