All Stories

  1. Thiocarbamate-Linked Polysulfonate–Peptide Conjugates As Selective Hepatocyte Growth Factor Receptor Binders

    Article • Bioconjugate Chemistry, May 2014, American Chemical Society (ACS)

    Oleg Melnyk

  2. Phenylthiocarbamate orN-Carbothiophenyl Group Chemistry in Peptide Synthesis and Bioconjugation

    Article • Bioconjugate Chemistry, March 2014, American Chemical Society (ACS)

    Oleg Melnyk

  3. ChemInform Abstract: Tidbits for the Synthesis of Bis(2‐sulfanylethyl)amido (SEA) Polystyrene Resin, SEA Peptides and Peptide Thioesters

    Article • ChemInform, March 2014, Wiley

    Oleg Melnyk

  4. Long peptide thioesters for accessing to functional ubiquitin-like peptide conjugates

    Article • Chemical Science, January 2014, Royal Society of Chemistry

    Oleg Melnyk

  5. Making SEA PS resin, SEA peptides and thioesters

    Article • Journal of Peptide Science, November 2013, Wiley

    Oleg Melnyk

  6. Bis(2-sulfanylethyl)amido Peptides Enable Native Chemical Ligation at Proline and Minimize Deletion Side-Product Formation

    Article • Organic Letters, October 2013, American Chemical Society (ACS)

    Oleg Melnyk

  7. Synthesis of Peptide Thioacids at Neutral pH Using Bis(2-sulfanylethyl)amido Peptide Precursors

    Article • Organic Letters, September 2013, American Chemical Society (ACS)

    Oleg Melnyk

  8. Se-(9-Fluorenylmethyl) Selenoesters; Preparation, Reactivity, and Use as Convenient Synthons for Selenoacids

    Article • Organic Letters, July 2013, American Chemical Society (ACS)

    Oleg Melnyk

  9. Total synthesis of biotinylated N domain of human hepatocyte growth factor

    Article • Bioorganic & Medicinal Chemistry, June 2013, Elsevier

    Oleg Melnyk

  10. Exploration of an imide capture/N,N-acyl shift sequence for asparagine native peptide bond formation

    Article • Bioorganic & Medicinal Chemistry, June 2013, Elsevier

    Oleg Melnyk, Kaname SASAKI

  11. α-Oxo Aldehyde or Glyoxylyl Group Chemistry in Peptide Bioconjugation

    Article • Bioconjugate Chemistry, April 2013, American Chemical Society (ACS)

    Oleg Melnyk

  12. Solid phase protein synthesis by sequential ligation of peptide segments

    Article • Chemical Science, January 2013, Royal Society of Chemistry

    Oleg Melnyk

  13. Direct Characterization of Native Chemical Ligation of Peptides on Silicon Nanowires

    Article • Langmuir, September 2012, American Chemical Society (ACS)

    Oleg Melnyk

  14. Shedding‐Generated Met Receptor Fragments can be Routed to Either the Proteasomal or the Lysosomal Degradation Pathway

    Article • Traffic, June 2012, Wiley

    Oleg Melnyk

  15. Access to Cyclic or Branched Peptides Using Bis(2-sulfanylethyl)amido Side-Chain Derivatives of Asp and Glu

    Article • Organic Letters, April 2012, American Chemical Society (ACS)

    Oleg Melnyk

  16. Surface-assisted laser desorption–ionization mass spectrometry on titanium dioxide (TiO2) nanotube layers

    Article • The Analyst, January 2012, Royal Society of Chemistry

    Oleg Melnyk

  17. Affinity surface-assisted laser desorption/ionization mass spectrometry for peptide enrichment

    Article • The Analyst, January 2012, Royal Society of Chemistry

    Oleg Melnyk

  18. Sequential native peptide ligation strategies for total chemical protein synthesis

    Article • Chemical Society Reviews, January 2012, Royal Society of Chemistry

    Oleg Melnyk

  19. Diamond nanowires for highly sensitive matrix-free mass spectrometry analysis of small molecules

    Article • Nanoscale, January 2012, Royal Society of Chemistry

    Oleg Melnyk

  20. A One‐Pot Three‐Segment Ligation Strategy for Protein Chemical Synthesis

    Article • Angewandte Chemie, November 2011, Wiley

    Oleg Melnyk

  21. A One‐Pot Three‐Segment Ligation Strategy for Protein Chemical Synthesis

    Article • Angewandte Chemie International Edition, November 2011, Wiley

    Oleg Melnyk

  22. Carbohydrate Microarrays in 96-Well Polystyrene Microtiter Plates

    Article • September 2011, Springer Science + Business Media

    Oleg Melnyk

  23. Polysaccharide Microarrays: Application to the Identification of Heparan Sulphate Mimetics

    Article • September 2011, Springer Science + Business Media

    Oleg Melnyk

  24. Three-Component Synthesis of Neoglycopeptides Using a Cu(II)-Triggered Aminolysis of Peptide Hydrazide Resin and an Azide–Alkyne Cycloaddition Sequence

    Article • Organic Letters, July 2011, American Chemical Society (ACS)

    Oleg Melnyk

  25. RYH: A minimal peptidic sequence obtained from beta-chain hemoglobin exhibiting an antimicrobial activity

    Article • Peptides, July 2011, Elsevier

    Oleg Melnyk

  26. Synthesis of Peptide Alkylthioesters Using the Intramolecular N,S-Acyl Shift Properties of Bis(2-sulfanylethyl)amido Peptides

    Article • The Journal of Organic Chemistry, March 2011, American Chemical Society (ACS)

    Oleg Melnyk

  27. Synthesis of Thiazolidine Thioester Peptides and Acceleration of Native Chemical Ligation

    Article • Organic Letters, February 2011, American Chemical Society (ACS)

    Oleg Melnyk

  28. High sensitive matrix-free mass spectrometry analysis of peptides using silicon nanowires-based digital microfluidic device

    Article • Lab on a Chip, January 2011, Royal Society of Chemistry

    Oleg Melnyk

  29. Chips from Chips: Application to the Study of Antibody Responses to Methylated Proteins

    Article • Journal of Proteome Research, November 2010, American Chemical Society (ACS)

    Oleg Melnyk

  30. Bis(2-sulfanylethyl)amino Native Peptide Ligation

    Article • Organic Letters, October 2010, American Chemical Society (ACS)

    Oleg Melnyk

  31. Assembly/Disassembly of Drug Conjugates Using Imide Ligation

    Article • Organic Letters, August 2010, American Chemical Society (ACS)

    Oleg Melnyk

  32. NMR‐based detection of acetylation sites in peptides

    Article • Journal of Peptide Science, July 2010, Wiley

    Oleg Melnyk

  33. Chemistry‐based protein modification strategy for endocytic pathway analysis

    Article • Biology of the Cell, June 2010, Wiley

    Oleg Melnyk

  34. Selective cleavage of an azaGly peptide bond by copper(II). Long‐range effect of histidine residue

    Article • Journal of Peptide Science, February 2010, Wiley

    Oleg Melnyk

  35. Synthesis of Peptide−Protein Conjugates Using N-Succinimidyl Carbamate Chemistry

    Article • Bioconjugate Chemistry, January 2010, American Chemical Society (ACS)

    Oleg Melnyk

  36. In Situ Chemical Modification of Peptide Microarrays: Characterization by Desorption/Ionization on Silicon Nanowires

    Article • January 2010, Springer Science + Business Media

    Oleg Melnyk

  37. In Situ Chemical Modification of Peptide Microarrays: Application to the Study of the Antibody Responses to Methylated Antigens

    Article • January 2010, Springer Science + Business Media

    Oleg Melnyk

  38. Photochemical Immobilization of Proteins and Peptides on Benzophenone-Terminated Boron-Doped Diamond Surfaces

    Article • Langmuir, October 2009, American Chemical Society (ACS)

    Oleg Melnyk

  39. Matrix-Free Laser Desorption/Ionization Mass Spectrometry on Silicon Nanowire Arrays Prepared by Chemical Etching of Crystalline Silicon

    Article • Langmuir, August 2009, American Chemical Society (ACS)

    Oleg Melnyk

  40. Love wave immunosensor for antibody recognition using an innovative semicarbazide surface functionalization

    Article • Sensors and Actuators B Chemical, July 2009, Elsevier

    Oleg Melnyk

  41. Silver-Catalyzed azaGly Ligation. Application to the Synthesis of Azapeptides and of Lipid−Peptide Conjugates

    Article • Bioconjugate Chemistry, June 2009, American Chemical Society (ACS)

    Oleg Melnyk

  42. The collagen assisted self-assembly of silicon nanowires

    Article • Nanotechnology, May 2009, Institute of Physics Publishing

    Oleg Melnyk

  43. ChemInform Abstract: Semicarbazide/α‐Oxoaldehyde Site‐Specific Ligation Chemistry —From Peptide Microarrays to the Micropatterning of Polycarbonate or Titanium Oxide Using Silica Nanoparticles

    Article • ChemInform, April 2009, Wiley

    Oleg Melnyk

  44. In Situ Ligation between Peptides and Silica Nanoparticles for Making Peptide Microarrays on Polycarbonate

    Article • Bioconjugate Chemistry, February 2009, American Chemical Society (ACS)

    Oleg Melnyk

  45. Peptide Microarrays on Bisphenol A Polycarbonate

    Article • January 2009, Springer Science + Business Media

    Oleg Melnyk

  46. PASE: A Web-Based Platform for Peptide/Protein Microarray Experiments

    Article • January 2009, Springer Science + Business Media

    Oleg Melnyk

  47. Towards thrombosis-targeted zeolitenanoparticles for laser-polarized129Xe MRI

    Article • Journal of Materials Chemistry, January 2009, Royal Society of Chemistry

    Oleg Melnyk

  48. Thiocarbamate‐linked peptides by chemoselective peptide ligation

    Article • Journal of Peptide Science, August 2008, Wiley

    Oleg Melnyk

  49. Characterization of Nanogap Chemical Reactivity Using Peptide-Capped Gold Nanoparticles and Electrical Detection

    Article • Bioconjugate Chemistry, March 2008, American Chemical Society (ACS)

    Oleg Melnyk

  50. Biomolecule and Nanoparticle Transfer on Patterned and Heterogeneously Wetted Superhydrophobic Silicon Nanowire Surfaces

    Article • Langmuir, February 2008, American Chemical Society (ACS)

    Oleg Melnyk

  51. Current based antibodies detection from human serum enhanced by secondary antibodies labelled with gold nanoparticles immobilized in a nanogap

    Article • Biosensors and Bioelectronics, February 2008, Elsevier

    Oleg Melnyk

  52. Ti-Cp functionalization by deposition of organic/inorganic silica nanoparticles

    Article • Biomolecular Engineering, November 2007, Elsevier

    Oleg Melnyk

  53. Parallel Synthesis of a Lipopeptide Library by Hydrazone-Based Chemical Ligation

    Article • Journal of Combinatorial Chemistry, September 2007, American Chemical Society (ACS)

    Oleg Melnyk

  54. Electrical Detection of Antibodies from Human Serum Based on the Insertion of Gold‐Labeled Secondary Antibodies into Microor Nanogaps

    Article • August 2007, Wiley

    Oleg Melnyk

  55. Semicarbazide/α‐Oxo Aldehyde Site‐Specific Ligation Chemistry: From Peptide Microarrays to the Micropatterning of Polycarbonate or Titanium Oxide Using Silica Nanoparticles

    Article • August 2007, Wiley

    Oleg Melnyk

  56. Electrical detection of human immunoglobulins G from human serum using a microbiosensor

    Article • Biosensors and Bioelectronics, August 2007, Elsevier

    Oleg Melnyk

  57. Reaction of Isocyanate‐Functionalised Silicon Wafers with Complex Amino Compounds

    Article • European Journal of Organic Chemistry, August 2007, Wiley

    Oleg Melnyk

  58. Imaging of protein layers with an optical microscope for the characterization of peptide microarrays

    Article • Journal of Peptide Science, June 2007, Wiley

    Oleg Melnyk

  59. Covalent linking of peptides onto oxygen-terminated boron-doped diamond surfaces

    Article • Diamond and Related Materials, April 2007, Elsevier

    Oleg Melnyk

  60. Peptide Immobilization on Amine-Terminated Boron-Doped Diamond Surfaces

    Article • Langmuir, March 2007, American Chemical Society (ACS)

    Oleg Melnyk

  61. Chemical Micropatterning of Polycarbonate for Site‐Specific Peptide Immobilization and Biomolecular Interactions

    Article • ChemBioChem, January 2007, Wiley

    Oleg Melnyk

  62. Determination of glyoxylyl‐peptide concentration using oxime chemistry and RP‐HPLC analysis

    Article • Journal of Peptide Science, September 2006, Wiley

    Oleg Melnyk

  63. Semicarbazide‐Functionalized Silicate Nanoparticles for Peptide Ligation

    Article • European Journal of Inorganic Chemistry, July 2006, Wiley

    Oleg Melnyk

  64. Detecting the Chemoselective Ligation of Peptides to Silicon with the Use of Cobalt−Carbonyl Labels

    Article • Langmuir, June 2006, American Chemical Society (ACS)

    Oleg Melnyk

  65. Polysaccharide Microarrays for Polysaccharide–Platelet‐Derived‐Growth‐Factor Interaction Studies

    Article • ChemBioChem, April 2006, Wiley

    Oleg Melnyk

  66. A novel phosphoramidite for the synthesis of α-oxo aldehyde-modified oligodeoxynucleotides

    Article • Tetrahedron, June 2005, Elsevier

    Oleg Melnyk

  67. Fmoc Solid-Phase Synthesis of Peptide Thioesters Using an IntramolecularN,S-Acyl Shift

    Article • Organic Letters, June 2005, American Chemical Society (ACS)

    Oleg Melnyk

  68. Hybrid Bioorganic–Inorganic Materials Prepared by Site‐Specific Ligation of Peptides to Functionalized Polydisperse Silica Particles

    Article • European Journal of Organic Chemistry, June 2005, Wiley

    Oleg Melnyk

  69. Anchorage of Synthetic Peptides onto Liposomes via Hydrazone and α-Oxo Hydrazone Bonds. Preliminary Functional Investigations

    Article • Bioconjugate Chemistry, February 2005, American Chemical Society (ACS)

    Oleg Melnyk

  70. Synthesis of glyoxylyl peptides using an Fmoc-protected α,α′-diaminoacetic acid derivative

    Article • Journal of Peptide Science, January 2005, Wiley

    Oleg Melnyk

  71. Preparation of α‐Oxo Semicarbazone Oligonucleotide Microarrays

    Article • Current Protocols in Nucleic Acid Chemistry, December 2004, Wiley

    Oleg Melnyk

  72. Synthesis of glyoxylyl peptides using a phosphine labile α,α′-diaminoacetic acid derivative

    Article • Tetrahedron Letters, September 2004, Elsevier

    Oleg Melnyk

  73. Peptide−Protein Microarrays for the Simultaneous Detection of Pathogen Infections

    Article • Bioconjugate Chemistry, February 2004, American Chemical Society (ACS)

    Oleg Melnyk

  74. Polypeptide Semicarbazide Glass Slide Microarrays: Characterization and Comparison with Amine Slides in Serodetection Studies

    Article • Bioconjugate Chemistry, February 2004, American Chemical Society (ACS)

    Oleg Melnyk

  75. Solid phase synthesis of mandelic acid-derived thioethers by α-keto carbocation trapping

    Article • Tetrahedron Letters, February 2004, Elsevier

    Oleg Melnyk

  76. A novel α,α ′ -diaminoacetic acid derivative for the introduction of the α-oxo aldehyde functionality into peptides

    Article • Tetrahedron Letters, February 2004, Elsevier

    Oleg Melnyk

  77. Synthesis and Chemical Reactivity of α‐Oxo Aldehyde‐Supported Silicas

    Article • European Journal of Organic Chemistry, October 2003, Wiley

    Oleg Melnyk

  78. Solid-Phase Functionalization of Peptides by an α-Hydrazinoacetyl Group

    Article • The Journal of Organic Chemistry, August 2003, American Chemical Society (ACS)

    Oleg Melnyk, Dr Dominique Bonnet

  79. COCHO-modified oxides nanoparticles by using phosphonic acid as grafting agent

    Article • Tetrahedron Letters, July 2003, Elsevier

    Oleg Melnyk

  80. Synthesis and chemical reactivity of semicarbazide-supported silicas

    Article • Tetrahedron Letters, May 2003, Elsevier

    Oleg Melnyk

  81. Comments on “Methyl phenylacetate enolate generated with the P4-tBu Schwesinger base: ‘naked’ or not?”

    Article • Tetrahedron Letters, March 2003, Elsevier

    Oleg Melnyk

  82. Simultaneous Lipidation of a Characterized Peptide Mixture by Chemoselective Ligation

    Article • Bioconjugate Chemistry, February 2003, American Chemical Society (ACS)

    Oleg Melnyk, Dr Dominique Bonnet

  83. α-Oxo Semicarbazone Peptide or Oligodeoxynucleotide Microarrays

    Article • Bioconjugate Chemistry, February 2003, American Chemical Society (ACS)

    Oleg Melnyk

  84. Synthesis and mannose receptor-Mediated uptake of clustered glycomimetics by human dendritic cells: effect of charge

    Article • Bioorganic & Medicinal Chemistry Letters, October 2002, Elsevier

    Oleg Melnyk

  85. Grafting of synthetic mannose receptor-ligands onto onion vectors for human dendritic cells targetingElectronic supplementary information (ESI) available: full experimental details. See http://www.rsc.org/suppdata/cc/b2/b206980f/

    Article • Chemical Communications, September 2002, Royal Society of Chemistry

    Oleg Melnyk

  86. Combined Thioether/Hydrazone Chemoselective Ligation Reactions for the Synthesis of Glycocluster−Antigen Peptide Conjugates

    Article • Bioconjugate Chemistry, June 2002, American Chemical Society (ACS)

    Oleg Melnyk

  87. Peptide Arrays for Highly Sensitive and Specific Antibody-Binding Fluorescence Assays

    Article • Bioconjugate Chemistry, June 2002, American Chemical Society (ACS)

    Oleg Melnyk

  88. Synthesis of oligonucleotide–peptide conjugates using hydrazone chemical ligation

    Article • Tetrahedron Letters, February 2002, Elsevier

    Oleg Melnyk

  89. ChemInform Abstract: Novel Hyperbranched Glycomimetics Recognized by the Human Mannose Receptor: Quinic or Shikimic Acid Derivatives as Mannose Bioisosteres.

    Article • ChemInform, January 2002, Wiley

    Oleg Melnyk

  90. Solid-Phase Enolate Chemistry Investigated Using HR-MAS NMR Spectroscopy

    Article • The Journal of Organic Chemistry, December 2001, American Chemical Society (ACS)

    Oleg Melnyk

  91. Methyl phenylacetate enolate generated with the P4-tBu Schwesinger base: ‘naked’ or not?

    Article • Tetrahedron Letters, December 2001, Elsevier

    Oleg Melnyk

  92. Corrigendum to “A novel family of amphiphilic α-oxo aldehydes for the site-specific modification of peptides by two palmitoyl groups in solution or in liposome suspensions”

    Article • Tetrahedron Letters, November 2001, Elsevier

    Oleg Melnyk

  93. A novel family of amphilic α-oxo aldehydes for the site-specific modification of peptides by two palmitoyl groups in solution or in liposome suspensions

    Article • Tetrahedron Letters, September 2001, Elsevier

    Oleg Melnyk

  94. Tartric Acid-Based Linker for the Solid-Phase Synthesis of C-Terminal Peptide α-Oxo Aldehydes

    Article • The Journal of Organic Chemistry, May 2001, American Chemical Society (ACS)

    Oleg Melnyk

  95. C-terminal glyoxylyl peptides for sensitive enzyme-linked immunosorbent assays

    Article • May 2001

    Oleg Melnyk

  96. Synthesis of an amphiphilic aldehyde using as a key step the condensation of a lipophilic glyoxylic acid amide derivative with tris(hydroxymethyl)aminomethane

    Article • Tetrahedron Letters, March 2001, Elsevier

    Oleg Melnyk, Dr Dominique Bonnet

  97. Synthesis by Chemoselective Ligation and Biological Evaluation of Novel Cell-Permeable PKC-ζ Pseudosubstrate Lipopeptides

    Article • Journal of Medicinal Chemistry, January 2001, American Chemical Society (ACS)

    Oleg Melnyk, Dr Dominique Bonnet

  98. Synthesis of Oligodeoxynucleotide-Peptide Conjugates Using Hydrazone Chemical Ligation

    Article • January 2001, Springer Science + Business Media

    Oleg Melnyk

  99. Simultaneous Lipidation of a Multi-Epitope Peptide Cocktail by Chemoselective Hydrazone Formation

    Article • January 2001, Springer Science + Business Media

    Oleg Melnyk, Dr Dominique Bonnet

  100. Chemoselective Acylation of Fully Deprotected Hydrazino Acetyl Peptides. Application to the Synthesis of Lipopeptides

    Article • The Journal of Organic Chemistry, December 2000, American Chemical Society (ACS)

    Oleg Melnyk, Dr Dominique Bonnet

  101. A novel lipophilic glyoxylic acid derivative for the lipidation of peptides using salt-free hydrazone ligation

    Article • Tetrahedron Letters, December 2000, Elsevier

    Oleg Melnyk, Dr Dominique Bonnet

  102. Structural diversity of human class II histocompatibility molecules induced by peptide ligands

    Article • FEBS Letters, September 2000, Wiley

    Oleg Melnyk

  103. Chemoselective acylation of hydrazinopeptides: a novel and mild method for the derivatization of peptides with sensitive fatty acids

    Article • Tetrahedron Letters, January 2000, Elsevier

    Oleg Melnyk, Dr Dominique Bonnet

  104. Convergent synthesis of fluorescein-labelled lysine-based cluster glycosides

    Article • Tetrahedron Letters, October 1999, Elsevier

    Oleg Melnyk

  105. A novel and mild solid phase hydroperoxydeamination reaction

    Article • Tetrahedron Letters, October 1999, Elsevier

    Oleg Melnyk, Dr Dominique Bonnet

  106. A new linker for the synthesis of C-terminal peptide α-oxo-aldehydes

    Article • Tetrahedron Letters, August 1999, Elsevier

    Oleg Melnyk

  107. Chemistry of hydrazinopeptides: a new hydroperoxydeamination process

    Article • Tetrahedron Letters, February 1999, Elsevier

    Oleg Melnyk

  108. Synthesis, folding, and structure of the β‐turn mimic modified B1 domain of streptococcal protein G

    Article • Protein Science, January 1999, Wiley

    Oleg Melnyk

  109. Convergent synthesis of D-(−)-quinic and shikimic acid-containing dendrimers as potential C-lectin ligands by sulfide ligation of unprotected fragments

    Article • Journal of the Chemical Society Perkin Transactions 1, January 1999, Royal Society of Chemistry

    Oleg Melnyk

  110. Synthesis and Structural and Functional Evaluation of a Protein Modified with a β-Turn Mimic

    Article • Journal of the American Chemical Society, June 1998, American Chemical Society (ACS)

    Oleg Melnyk

  111. Incorporation of a β-turn mimic in the N-terminal fragment of the B1 domain of streptococcal protein G

    Article • May 1998

    Oleg Melnyk

  112. A General Approach to the Synthesis of Polyamine Linked-Monoindolylmaleimides, a New Series of Trypanothione Reductase Inhibitors.

    Article • Chemical and Pharmaceutical Bulletin, January 1998, Pharmaceutical Society of Japan

    Oleg Melnyk, Elisabeth Davioud-Charvet

  113. Synthesis of hydrazinopeptides using solid phase N-amination. Application to chemical ligation

    Article • Tetrahedron Letters, September 1996, Elsevier

    Oleg Melnyk

  114. One-pot synthesis of dissymmetrical 4,6-disubstituted dibenzofurans

    Article • Tetrahedron Letters, October 1995, Elsevier

    Oleg Melnyk

  115. Additions diastéréosélectives d'alkyl, alcényl, aryl et allyl cuprates à des imides chirales insaturées

    Article • Tetrahedron, January 1992, Elsevier

    Oleg Melnyk