All Stories

  1. Use of Backbone Modification To Enlarge the Spatiotemporal Diversity of Parathyroid Hormone Receptor-1 Signaling via Biased Agonism

    Article • Journal of the American Chemical Society, September 2019, American Chemical Society (ACS)

    Frederic JEAN-ALPHONSE

  2. Structure and dynamics of the active human parathyroid hormone receptor-1

    Article • Science, April 2019, American Association for the Advancement of Science

    Frederic JEAN-ALPHONSE

  3. Biased Signaling and Allosteric Modulation at the FSHR

    Article • Frontiers in Endocrinology, March 2019, Frontiers

    Frederic JEAN-ALPHONSE

  4. Ca 2+ allostery in PTH-receptor signaling

    Article • Proceedings of the National Academy of Sciences, February 2019, Proceedings of the National Academy of Sciences

    Frederic JEAN-ALPHONSE

  5. Parathyroid hormone initiates dynamic NHERF1 phosphorylation cycling and conformational changes that regulate NPT2A-dependent phosphate transport

    Article • Journal of Biological Chemistry, January 2019, American Society for Biochemistry & Molecular Biology (ASBMB)

    Frederic JEAN-ALPHONSE

  6. Integration of GPCR Signaling and Sorting from Very Early Endosomes via Opposing APPL1 Mechanisms

    Article • Cell Reports, December 2017, Elsevier

    Frederic JEAN-ALPHONSE

  7. Cdc42 activation couples fluid shear stress to apical endocytosis in proximal tubule cells

    Article • Physiological Reports, October 2017, Wiley

    Frederic JEAN-ALPHONSE, Jean-Pierre Vilardaga

  8. Dual role of mitochondria in producing melatonin and driving GPCR signaling to block cytochrome c release

    Article • Proceedings of the National Academy of Sciences, September 2017, Proceedings of the National Academy of Sciences

    Frederic JEAN-ALPHONSE

  9. Design and validation of the first cell-impermeant melatonin receptor agonist

    Article • British Journal of Pharmacology, June 2017, Wiley

    Frederic JEAN-ALPHONSE

  10. Endosomal PTH Receptor Signaling Through cAMP and Its Consequence for Human Medicine

    Article • January 2017, Springer Science + Business Media

    Frederic JEAN-ALPHONSE

  11. β2-adrenergic receptor control of endosomal PTH receptor signaling via Gβγ

    Article • Nature Methods, December 2016, Nature

    Frederic JEAN-ALPHONSE

  12. Actin-Sorting Nexin 27 (SNX27)-Retromer Complex Mediates Rapid Parathyroid Hormone Receptor Recycling

    Article • Journal of Biological Chemistry, March 2016, American Society for Biochemistry & Molecular Biology (ASBMB)

    Frederic JEAN-ALPHONSE

  13. Decoding gonadotrophin receptor signalling via spatial regulation of the LH receptor

    Article • Endocrine Abstracts, October 2015, Bioscientifica

    Frederic JEAN-ALPHONSE

  14. The Polycystin-1, Lipoxygenase, and α-Toxin Domain Regulates Polycystin-1 Trafficking

    Article • Journal of the American Society of Nephrology, August 2015, American Society of Nephrology

    Frederic JEAN-ALPHONSE, Professor Albert Ong

  15. Arachidonic acid-dependent gene regulation during preadipocyte differentiation controls adipocyte potential

    Article • Journal of Lipid Research, October 2014, American Society for Biochemistry & Molecular Biology (ASBMB)

    Frederic JEAN-ALPHONSE

  16. Endosomal generation of cAMP in GPCR signaling

    Article • Nature Methods, September 2014, Nature

    Frederic JEAN-ALPHONSE

  17. Endosomal GPCR signaling turned off by negative feedback actions of PKA and v-ATPase

    Article • Nature Methods, July 2014, Nature

    Frederic JEAN-ALPHONSE

  18. Post-endocytic sorting of the LH receptor is mediated by a novel APPL1 dependent mechanism

    Article • Endocrine Abstracts, March 2014, Bioscientifica

    Frederic JEAN-ALPHONSE

  19. Spatially Restricted G Protein-coupled Receptor Activity via Divergent Endocytic Compartments

    Article • Journal of Biological Chemistry, December 2013, American Society for Biochemistry & Molecular Biology (ASBMB)

    Frederic JEAN-ALPHONSE

  20. Identification of very early sorting endosomes that spatially program gonadotrophin hormone receptor signalling

    Article • Endocrine Abstracts, March 2013, Bioscientifica

    Frederic JEAN-ALPHONSE

  21. Regulation of GPCR signal networks via membrane trafficking

    Article • Molecular and Cellular Endocrinology, January 2011, Elsevier

    Frederic JEAN-ALPHONSE

  22. Past, present and future of vasopressin and oxytocin receptor oligomers, prototypical GPCR models to study dimerization processes

    Article • Current Opinion in Pharmacology, February 2010, Elsevier

    Frederic JEAN-ALPHONSE

  23. Biased Agonist Pharmacochaperones of the AVP V2 Receptor May Treat Congenital Nephrogenic Diabetes Insipidus

    Article • Journal of the American Society of Nephrology, September 2009, American Society of Nephrology

    Dr Dominique Bonnet, Frederic JEAN-ALPHONSE

  24. The multifunctional protein GC1q-R interacts specifically with the i3 loop arginine cluster of the vasopressin V2 receptor

    Article • Regulatory Peptides, June 2008, Elsevier

    Frederic JEAN-ALPHONSE

  25. Design and synthesis of cyclic and linear peptide-agarose tools for baiting interacting protein partners of GPCRs

    Article • Bioorganic & Medicinal Chemistry Letters, February 2006, Elsevier

    Frederic JEAN-ALPHONSE