All Stories

  1. A rational roadmap for SARS‐CoV‐2/COVID‐19 pharmacotherapeutic research and development. IUPHAR Review 29

    Article • British Journal of Pharmacology, May 2020, Wiley

    Dr Christopher Southan, Professor Jamie A Davies, Stephen Alexander

  2. Opening up connectivity between documents, structures and bioactivity

    Article • Beilstein Journal of Organic Chemistry, April 2020, Beilstein Institut

    Dr Christopher Southan

  3. Déjà vu: Stimulating Open Drug Discovery for SARS-CoV-2

    Article • March 2020, Center for Open Science

    Dr Christopher Southan

  4. Hydrolases (version 2019.5) in the IUPHAR/BPS Guide to Pharmacology Database

    Article • IUPHAR/BPS Guide to Pharmacology CITE, November 2019, Edinburgh University Library

    Dr Christopher Southan, Stephen Alexander

  5. Hydrolases (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

    Article • IUPHAR/BPS Guide to Pharmacology CITE, September 2019, Edinburgh University Library

    Stephen Alexander, Dr Christopher Southan

  6. A new guide to immunopharmacology

    Article • Nature Reviews Immunology, October 2018, Springer Science + Business Media

    Dr Christopher Southan

  7. Challenges of Connecting Chemistry to Pharmacology: Perspectives from Curating the IUPHAR/BPS Guide to PHARMACOLOGY

    Article • ACS Omega, July 2018, American Chemical Society (ACS)

    Dr Christopher Southan

  8. SynPharm - a new tool to help Synthetic Biologists create proteins which respond to existing drugs

    Article • ACS Omega, July 2018, American Chemical Society (ACS)

    Dr Christopher Southan, Sam Ireland

  9. Accessing Expert-Curated Pharmacological Data in the IUPHAR/BPS Guide to PHARMACOLOGY

    Article • Current Protocols in Bioinformatics, March 2018, Wiley

    Dr Christopher Southan

  10. Caveat Usor: Assessing Differences between Major Chemistry Databases

    Article • ChemMedChem, February 2018, Wiley

    Dr Christopher Southan

  11. An open-access tool for designing drug control into engineered proteins

    Article • January 2018, American Chemical Society (ACS)

    Dr Christopher Southan

  12. Challenges of Connecting Chemistry to Pharmacology: Perspectives from Curating the IUPHAR/BPS Guide to PHARMACOLOGY

    Article • January 2018, American Chemical Society (ACS)

    Dr Christopher Southan

  13. Can we devise new therapies by combining databases of protein interactions and of drug targets?

    Article • British Journal of Pharmacology, November 2017, Wiley

    Dr Christopher Southan, Steven Watterson

  14. THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: Catalytic receptors

    Article • British Journal of Pharmacology, October 2017, Wiley

    Stephen Alexander, Dr Christopher Southan, Professor Jamie A Davies

  15. THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: Other ion channels

    Article • British Journal of Pharmacology, October 2017, Wiley

    Stephen Alexander, Dr Christopher Southan, Professor Jamie A Davies

  16. THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: Enzymes

    Article • British Journal of Pharmacology, October 2017, Wiley

    Stephen Alexander, Dr Christopher Southan, Professor Jamie A Davies

  17. THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: Transporters

    Article • British Journal of Pharmacology, October 2017, Wiley

    Stephen Alexander, Dr Christopher Southan, Professor Jamie A Davies

  18. THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: G protein-coupled receptors

    Article • British Journal of Pharmacology, October 2017, Wiley

    Dr Christopher Southan, Dr Anthony P Davenport, Stephen Alexander, Professor Jamie A Davies

  19. THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: Ligand-gated ion channels

    Article • British Journal of Pharmacology, October 2017, Wiley

    Dr Christopher Southan, Stephen Alexander, Professor Jamie A Davies

  20. THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: Nuclear hormone receptors

    Article • British Journal of Pharmacology, October 2017, Wiley

    Dr Christopher Southan, Stephen Alexander, Professor Jamie A Davies

  21. THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: Overview

    Article • British Journal of Pharmacology, October 2017, Wiley

    Dr Christopher Southan, Dr Anthony P Davenport, Professor Israel Hanukoglu, Professor Jamie A Davies, Prof daniel hoyer, Professor of Vascular Physiology Lucie Clapp

  22. THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: Voltage-gated ion channels

    Article • British Journal of Pharmacology, October 2017, Wiley

    Dr Christopher Southan, Stephen Alexander, Professor Jamie A Davies

  23. Counting human proteins

    Article • F1000Research, April 2017, Faculty of 1000, Ltd.

    Dr Christopher Southan

  24. OUP accepted manuscript

    Article • Nucleic Acids Research, January 2017, Oxford University Press (OUP)

    Dr Christopher Southan, Dr Anthony P Davenport, Stephen Alexander

  25. Selected GPCR resources

    Article • Current Opinion in Pharmacology, October 2016, Elsevier

    Dr Christopher Southan

  26. Illustrating and homology modeling the proteins of the Zika virus

    Article • F1000Research, September 2016, Faculty of 1000, Ltd.

    Dr Sean Ekins, Dr Christopher Southan, Megan Coffee

  27. The endothelin hormones, structure and function

    Article • Pharmacological Reviews, March 2016, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Dr Christopher Southan, Dr Anthony P Davenport

  28. Modeling the proteins in the Zika virus

    Article • F1000Research, March 2016, Faculty of 1000, Ltd.

    Dr Sean Ekins, Dr Rachelle J Bienstock, Dr Carolina Horta Andrade, Dr Christopher Southan, Megan Coffee

  29. The Concise Guide to PHARMACOLOGY 2015/16: Catalytic receptors

    Article • British Journal of Pharmacology, December 2015, Wiley

    Dr Christopher Southan, Stephen Alexander

  30. A focus on the enzymes for which there is pharmacological or therapeutic interest

    Article • British Journal of Pharmacology, December 2015, Wiley

    Dr Christopher Southan, Stephen Alexander

  31. The Concise Guide to PHARMACOLOGY 2015/16: G protein-coupled receptors

    Article • British Journal of Pharmacology, December 2015, Wiley

    Dr Christopher Southan, Dr Anthony P Davenport, Dr Kenneth A. Jacobson, Stephen Alexander

  32. The Concise Guide to PHARMACOLOGY 2015/16: Ligand-gated ion channels

    Article • British Journal of Pharmacology, December 2015, Wiley

    Dr Christopher Southan, Stephen Alexander

  33. The Concise Guide to PHARMACOLOGY 2015/16: Nuclear hormone receptors

    Article • British Journal of Pharmacology, December 2015, Wiley

    Dr Christopher Southan, Stephen Alexander

  34. The Concise Guide to PHARMACOLOGY 2015/16: Other ion channels

    Article • British Journal of Pharmacology, December 2015, Wiley

    Dr Christopher Southan, Stephen Alexander

  35. The Concise Guide to PHARMACOLOGY 2015/16: Transporters

    Article • British Journal of Pharmacology, December 2015, Wiley

    Dr Christopher Southan, Stephen Alexander

  36. The Concise Guide to PHARMACOLOGY 2015/16: Voltage-gated ion channels

    Article • British Journal of Pharmacology, December 2015, Wiley

    Dr Christopher Southan, Stephen Alexander

  37. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands

    Article • Nucleic Acids Research, October 2015, Oxford University Press (OUP)

    Dr Christopher Southan, Dr Anthony P Davenport, Stephen Alexander

  38. Addressing the next viral outbreak

    Article • F1000Research, July 2015, Faculty of 1000, Ltd.

    Dr Sean Ekins, Dr Christopher Southan, Megan Coffee

  39. Expanding opportunities for mining bioactive chemistry from patents

    Article • Drug Discovery Today Technologies, July 2015, Elsevier

    Dr Christopher Southan

  40. How do we fight the next pathogen we discover?

    Article • F1000Research, February 2015, Faculty of 1000, Ltd.

    Dr Sean Ekins, Dr Christopher Southan, Megan Coffee

  41. Associated challenges with the divergent expansions of public and commercial sources of molecules

    Article • Journal of Medicinal Chemistry, December 2014, American Chemical Society (ACS)

    Dr Antony John Williams, Dr Sean Ekins, Dr Christopher Southan, Dr Nadia Litterman, Dr Christopher A Lipinski

  42. Comparing the Chemical Structure and Protein Content of ChEMBL, DrugBank, Human Metabolome Database and the Therapeutic Target Database

    Article • Molecular Informatics, December 2013, Wiley

    Dr Christopher Southan

  43. The IUPHAR/BPS Guide to PHARMACOLOGY: an expert-driven knowledgebase of drug targets and their ligands

    Article • Nucleic Acids Research, November 2013, Oxford University Press (OUP)

    Dr Christopher Southan, Dr Anthony P Davenport, Stephen Alexander

  44. Tracking 20 Years of Compound-to-Target Output from Literature and Patents

    Article • PLoS ONE, October 2013, PLOS

    Dr Christopher Southan

  45. Extracting and connecting chemical structures from text sources using chemicalize.org

    Article • Journal of Cheminformatics, April 2013, Springer Science + Business Media

    Dr Christopher Southan

  46. BACE2 as a new diabetes target: a patent review (2010 – 2012)

    Article • Expert Opinion on Therapeutic Patents, March 2013, Informa Healthcare

    Dr Christopher Southan

  47. InChI in the wild: an assessment of InChIKey searching in Google

    Article • Journal of Cheminformatics, February 2013, Springer Science + Business Media

    Dr Christopher Southan

  48. Challenges associated with obtaining chemical structures of repurposing candidates from an online DB

    Article • Drug Discovery Today, January 2013, Elsevier

    Dr Antony John Williams, Dr Sean Ekins, Dr Christopher Southan

  49. A tale of two drug targets: the evolutionary history of BACE1 and BACE2

    Article • Frontiers in Genetics, January 2013, Frontiers

    Dr Christopher Southan, Dr John M Hancock

  50. Shouldn't enantiomeric purity be included in the 'minimum information about a bioactive entity? Response from the MIABE group

    Article • Nature Reviews Cancer, August 2012, Springer Science + Business Media

    Dr Christopher Southan

  51. SARConnect: A Tool to Interrogate the Connectivity Between Proteins, Chemical Structures and Activity Data

    Article • Molecular Informatics, August 2012, Wiley

    Dr Christopher Southan, Dr Niklas U Blomberg

  52. Mapping Between Databases of Compounds and Protein Targets

    Article • January 2012, Springer Science + Business Media

    Dr Christopher Southan

  53. Making every SAR point count: the development of Chemistry Connect for the large-scale integration of structure and bioactivity data

    Article • Drug Discovery Today, December 2011, Elsevier

    Dr Christopher Southan

  54. Minimum information about a bioactive entity (MIABE)

    Article • Nature Reviews Cancer, August 2011, Springer Science + Business Media

    Dr Christopher Southan

  55. Analysis of in vitrobioactivity data extracted from drug discovery literature and patents: Ranking 1654 human protein targets by assayed compounds and molecular scaffolds

    Article • Journal of Cheminformatics, May 2011, Springer Science + Business Media

    Dr Christopher Southan

  56. Towards BioDBcore: a community-defined information specification for biological databases

    Article • Database, January 2011, Oxford University Press (OUP)

    Dr Christopher Southan

  57. Towards BioDBcore: a community-defined information specification for biological databases

    Article • Nucleic Acids Research, November 2010, Oxford University Press (OUP)

    Dr Christopher Southan, Dr John M Hancock

  58. The Cinderella of Biological Data Integration: Addressing Some of the Challenges of Entity and Relationship Mining from Patent Sources

    Article • January 2010, Springer Science + Business Media

    Dr Christopher Southan

  59. Quantitative assessment of the expanding complementarity between public and commercial databases of bioactive compounds

    Article • Journal of Cheminformatics, July 2009, Springer Science + Business Media

    Dr Christopher Southan

  60. The Yoyo Has Stopped: Reviewing the Evidence for a Low Basal Human Protein Number

    Article • June 2009, SciVee, Inc

    Dr Christopher Southan

  61. Thrombin-induced fibrinopeptide release from a fibrinogen variant (fibrinogen Sydney I) with an Aα Arg-16 → His substitution

    Article • European Journal of Biochemistry, June 2008, Wiley

    Dr Christopher Southan

  62. Proteases: Evolution

    Article • April 2008, Wiley

    Dr Christopher Southan

  63. Complementarity Between Public and Commercial Databases: New Opportunities in Medicinal Chemistry Informatics

    Article • Current Topics in Medicinal Chemistry, August 2007, Bentham Science Publishers

    Dr Christopher Southan

  64. Exploiting new genome data and Internet resources for the phylogenetic analysis of proteases, substrates and inhibitors

    Article • Biochemical Society Transactions, June 2007, Portland Press Ltd.

    Dr Christopher Southan

  65. Finding, Delineating and Analysing Genes

    Article • March 2007, Wiley

    Dr Christopher Southan

  66. Proteases: Evolution

    Article • September 2006, Wiley

    Dr Christopher Southan

  67. Has the yo-yo stopped? An assessment of human protein-coding gene number

    Article • PROTEOMICS, June 2004, Wiley

    Dr Christopher Southan

  68. Splice variants: A homology modeling approach

    Article • Proteins Structure Function and Bioinformatics, December 2003, Wiley

    Dr Christopher Southan

  69. The HtrA Family of Proteases

    Article • Molecular Cell, September 2002, Elsevier

    Dr Christopher Southan

  70. The characterisation of novel secreted Ly-6 proteins from rat urine by the combined use of two-dimensional gel electrophoresis, microbore high performance liquid chromatography and expressed sequence tag data

    Article • PROTEOMICS, February 2002, Wiley

    Dr Christopher Southan

  71. Identification, Genomic Organization, and mRNA Expression of LACTB, Encoding a Serine β-Lactamase-like Protein with an Amino-terminal Transmembrane Domain

    Article • Genomics, November 2001, Elsevier

    Dr Christopher Southan

  72. A genomic perspective on human proteases as drug targets

    Article • Drug Discovery Today, July 2001, Elsevier

    Dr Christopher Southan

  73. A genomic perspective on human proteases

    Article • FEBS Letters, June 2001, Wiley

    Dr Christopher Southan

  74. Website Review: InterPro (The Integrated Resource of Protein Domains and Functional Sites). http://www.ebi.ac.uk/interpro/

    Article • Yeast, December 2000, Wiley

    Dr Christopher Southan

  75. ASP1 (BACE2) Cleaves the Amyloid Precursor Protein at the β-Secretase Site

    Article • Molecular and Cellular Neuroscience, November 2000, Elsevier

    Dr Christopher Southan

  76. Characterization of human HtrA2, a novel serine protease involved in the mammalian cellular stress response

    Article • European Journal of Biochemistry, September 2000, Wiley

    Dr Christopher Southan

  77. THE VERTEBRATE HTRA SERINE PROTEASE FAMILY; A NEW EXAMPLE OF HORIZONTAL GENE TRANSFER

    Article • Biochemical Society Transactions, February 2000, Portland Press Ltd.

    Dr Christopher Southan

  78. Sequencing, tissue distribution and chromosomal assignment of a novel ubiquitin-specific protease USP23

    Article • Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, January 2000, Elsevier

    Dr Christopher Southan

  79. Assessing the protease and protease inhibitor content of the human genome

    Article • Journal of Peptide Science, January 2000, Wiley

    Dr Christopher Southan

  80. The Impact of Genomics on Drug Discovery

    Article • Progress in Medicinal Chemistry, January 2000, Elsevier

    Dr Christopher Southan

  81. InterPro (The Integrated Resource of Protein Domains and Functional Sites)

    Article • Yeast, January 2000, Hindawi Publishing Corporation

    Dr Christopher Southan

  82. Identification of a Novel Aspartic Protease (Asp 2) as β-Secretase

    Article • Molecular and Cellular Neuroscience, December 1999, Elsevier

    Dr Christopher Southan

  83. Disposable Microbore High-Pressure Liquid Chromatography Columns for Protein and Peptide Separations

    Article • Analytical Biochemistry, July 1999, Elsevier

    Dr Christopher Southan

  84. Synergistic scale-down of three protein micropreparation techniques

    Article • The Protein Journal, August 1992, Springer Science + Business Media

    Dr Christopher Southan

  85. CHROMATOGRAPHIC CARBON AS AN INERT SAMPLE ADSORBENT FOR PROTEIN SEQUENCING

    Article • January 1992, Elsevier

    Dr Christopher Southan

  86. Analytical and micropreparative capillary electrophoresis of the peptides from calcitonin

    Article • Analytical Biochemistry, October 1991, Elsevier

    Dr Christopher Southan

  87. Separation by capillary electrophoresis followed by dynamic elution

    Article • Analytical Biochemistry, July 1991, Elsevier

    Dr Christopher Southan

  88. Bovine dopamine .beta.-hydroxylase, primary structure determined by cDNA cloning and amino acid sequencing

    Article • Biochemistry, July 1990, American Chemical Society (ACS)

    Dr Christopher Southan

  89. Inactivation of dopamine β-hydroxylase by p-cresol: Evidence for a second, minor site of covalent modification at tyrosine 357

    Article • Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, February 1990, Elsevier

    Dr Christopher Southan

  90. Purification to apparent homogeneity and partial amino acid sequence of rat liver O 6 -alkylguanine-DNA-alkyltransferase

    Article • Nucleic Acids Research, January 1990, Oxford University Press (OUP)

    Dr Christopher Southan

  91. Sequence similarity between dopamine β‐hydroxylase and peptide α‐amidating enzyme: Evidence for a conserved catalytic domain

    Article • FEBS Letters, September 1989, Wiley

    Dr Christopher Southan

  92. Inactivation of dopamine .beta.-hydroxylase by .beta.-ethynyltyramine: kinetic characterization and covalent modification of an active site peptide

    Article • Biochemistry, May 1989, American Chemical Society (ACS)

    Dr Christopher Southan

  93. THE USE OF GLASS CAPILLARY TUBES AS DISPOSABLE MICROBORE COLUMNS FOR RP-HPLC OF PROTEINS AND PEPTIDES

    Article • January 1989, Elsevier

    Dr Christopher Southan

  94. Inactivation of dopamine .beta.-hydroxylase by p-cresol: isolation and characterization of covalently modified active site peptides

    Article • Biochemistry, December 1988, American Chemical Society (ACS)

    Dr Christopher Southan

  95. The nitroreductase enzyme in walker cells that activates 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB 1954) to 5-(aziridin-1-YL)-4-hydroxylamino-2-nitrobenzamide is a form of NAD(P)H dehydrogenase (quinone) (EC 1.6.99.2)

    Article • Biochemical Pharmacology, December 1988, Elsevier

    Dr Christopher Southan

  96. Use of sep-pak cartridges for on-line preparative high-performance liquid chromatography

    Article • Journal of Chromatography A, June 1987, Elsevier

    Dr Christopher Southan

  97. Amino acid sequence of β‐galactoside‐binding bovine heart lectin

    Article • FEBS Letters, April 1987, Wiley

    Dr Christopher Southan

  98. Direct analysis of plasma fibrinogen‐derived fibrinopeptides by high‐performance liquid chromatography: investigation of nine congenital fibrinogen abnormalities

    Article • British Journal of Haematology, April 1987, Wiley

    Dr Christopher Southan

  99. Direct analysis of plasma fibrinogen-derived fibrinopeptides by high-performance liquid chromatography

    Article • Thrombosis Research, July 1986, Elsevier

    Dr Christopher Southan

  100. COVALENT STRUCTURE OF FIBRINOGEN

    Article • Annals of the New York Academy of Sciences, June 1983, Wiley

    Dr Christopher Southan

  101. Fibrinogen Manchester: identification of an abnormal fibrinopeptide A with a C-terminal arginine→histidine substitution

    Article • British Journal of Haematology, May 1983, Wiley

    Dr Christopher Southan

  102. Delayed release of an abnormal fibrinopeptide A from fibrinogen Manchester: effect of the Aα 16 Arg → His substitution upon fibrin monomer polymerization and the immunological crossreactivity of the peptide

    Article • British Journal of Haematology, April 1983, Wiley

    Dr Christopher Southan

  103. The ELIXIR Database Provider Survey

    Article • SciVee, Inc

    Dr Christopher Southan

  104. Finding, Delineating and Analysing Genes

    Article • Wiley

    Dr Christopher Southan

  105. Internet Resources for the Geneticist

    Article • Wiley

    Dr Christopher Southan

  106. A Bioinformatics Perspective on Genetics in Drug Discovery and Development

    Article • Wiley

    Dr Christopher Southan