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We studied the effects of psilocybin therapy on personality traits in patients with alcohol use disorder (AUD). Compared to active placebo, psilocybin reduced personality abnormalities, moving patients closer to people without AUD. Those who showed larger decreases in the personality trait impulsivity after psilocybin treatment were found to drink less alcohol.

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This page is a summary of: Multidimensional Personality Changes Following Psilocybin-Assisted Therapy in Patients With Alcohol Use Disorder: Results From a Double-Blind, Placebo-Controlled Clinical Trial, American Journal of Psychiatry, January 2025, American Psychiatric Association,
DOI: 10.1176/appi.ajp.20230887.
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