What is it about?
During ageing, damage and injury accumulate in the blood vessels in the brain in every individual to some extent. The damage caused to blood vessels is called small vessel disease. Small vessel disease is significantly present in about 50% of individuals >65 years. Small vessel disease is a well-known cause of stroke. However, the most important symptoms of small vessel disease are cognitive impairments, which also set the link with dementia. Nevertheless, a causal relation between small vessel disease and dementia has not yet been established. In this stuyd we followed patients with small vessel disease over a 14 years and have performed neuropsychological tests and MRI scans of the brains every 5 years. We observed that patienst with the highest burden of small vessel disease have the highest risk of dementia. But maybe more interestingly, prgression of small vessel disease over the years was also associated with getting dementia.
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Why is it important?
Our data suggest that SVD (progression) prior to dementia onset, increases the risk of dementia and provide strong evidence for a causal role of SVD in the development of dementia. Consequently, these observations position SVD as a modifiable target for dementia prevention.
Perspectives
Future studies should examine whether mitigating SVD could also prevent or even delay dementia. Because even a delay in disease onset by merely a few years could already reduce the devastating burden of dementia substantially.
Mina Jacob
Read the Original
This page is a summary of: Cerebral Small Vessel Disease Progression and the Risk of Dementia: A 14-Year Follow-Up Study, American Journal of Psychiatry, July 2023, American Psychiatric Association,
DOI: 10.1176/appi.ajp.20220380.
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