AlphaFold 3 benchmark on RNA 3D structures.

What is it about?

AlphaFold has achieved significant success in protein prediction and has even won a Nobel Prize. The latest version, AlphaFold 3, expands its capabilities to include predictions for various molecules, specifically RNAs. What are the current limitations on RNAs?

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Why is it important?

While the original AlphaFold 3 paper describes the performances on a unique dataset for RNA, we provide a complete benchmark and a comparison with state-of-the-art models. Our benchmark comprises five complementary datasets to assess the current limitations of AlphaFold 3 for RNAs.

Perspectives

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This article provides a detailed overview of the current limitations in RNA 3D structure prediction. It aims to offer insights into the existing bottlenecks in this field, particularly regarding the AlphaFold 3 model.

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