A new anthelmintic salt

What is it about?

In this work, we the design, synthesis and chracterization of a mebendazole (MBZ) salt aiming to obtain a new material incorporating the drug and avoiding polymorph inter­conversion and exhibiting a solubility and dissolution profile similar to those of the MBZ therapeutically preferred form C. This salt crystallizes in the monoclinic P21/c (No. 14) space group. A detailed study of the crystal structure performed by atom-to-atom and global Hirshfeld surface analysis indicates that several hydrogen bonds act as the main inter­molecular inter­actions stabillizing the material.

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Photo by James Yarema on Unsplash

Photo by James Yarema on Unsplash

Why is it important?

We obtained a new mebendazolium di­hydrogen phosphate phospho­ric acid compound. This material can be considered as an ionic cocrystal (i.e., a cocrystal of a salt), since the phospho­ric acid mol­ecules are connected with the ionic components of the salt through non-covalent inter­actions (i.e., hydrogen-bonds). Phospho­ric acid and its anions are approved coformers by the Food and Drug Administration (FDA), which could make this new material suitable for pharmaceutical formulations. The new material is stable up to 185 °C.

Perspectives

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Our project will continue with the screening of new mebendazole multicomponent materials that could be useful for pharmaceutical sciences and industries.

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