All Stories

  1. Brief, repeated isoflurane anaesthesia elicits sex-dependent behavioural, cerebrovascular, and microglial alterations in mice

    Article • February 2026, openRxiv

    Dr Simon McArthur

  2. A novel Mediterranean diet-inspired supplement reduces hippocampal amyloid deposits and microglial activation through the modulation of the microbiota gut-brain axis in 5xFAD mice

    Article • Gut Microbes, January 2026, Taylor & Francis

    Dr Simon McArthur

  3. Building a roadmap to nutrition for Healthy Ageing: a brief report on the ILSI Europe Healthy Ageing Task Force

    Article • The journal of nutrition health & aging, November 2025, Elsevier

    Dr Simon McArthur, Dr David Vauzour

  4. A standardised saffron extract improves subjective and objective sleep quality in healthy older adults with sleep complaints: results from the Gut-Sleep-Brain Axis randomised, double-blind, placebo-controlled pilot study

    Article • February 2025, Cold Spring Harbor Laboratory Press

    Dr Simon McArthur, Dr David Vauzour

  5. Dietary substances and their glucuronides: structures, occurrence and biological activity

    Article • Natural Product Reports, January 2025, Royal Society of Chemistry

    Dr Simon McArthur

  6. Dietary (Poly)phenols and the Gut–Brain Axis in Ageing

    Article • Nutrients, May 2024, MDPI AG

    Dr David Vauzour, Dr Simon McArthur

  7. Stimulation of the Pro-Resolving Receptor Fpr2 Reverses Inflammatory Microglial Activity by Suppressing NFκB Activity

    Article • International Journal of Molecular Sciences, November 2023, MDPI AG

    Dr Simon McArthur

  8. Regulation of Physiological Barrier Function by the Commensal Microbiota

    Article • Life, January 2023, MDPI AG

    Dr Simon McArthur

  9. Promiscuous Receptors and Neuroinflammation: The Formyl Peptide Class

    Article • Life, December 2022, MDPI AG

    Dr Simon McArthur

  10. A host–gut microbial amino acid co-metabolite, p-cresol glucuronide, promotes blood–brain barrier integrity in vivo

    Article • Tissue Barriers, May 2022, Taylor & Francis

    Dr Simon McArthur

  11. A host–gut microbial co-metabolite of aromatic amino acids, p-cresol glucuronide, promotes blood–brain barrier integrity in vivo

    Article • January 2022, Cold Spring Harbor Laboratory Press

    Dr Simon McArthur

  12. Impact of metabolic disorders on the structural, functional, and immunological integrity of the blood‐brain barrier: Therapeutic avenues

    Article • The FASEB Journal, December 2021, Wiley

    Dr Simon McArthur

  13. Regulation of blood–brain barrier integrity by microbiome-associated methylamines and cognition by trimethylamine N-oxide

    Article • Microbiome, November 2021, Springer Science + Business Media

    Dr David Vauzour, Dr Simon McArthur

  14. Exploiting formyl peptide receptor 2 to promote microglial resolution: a new approach to Alzheimer’s disease treatment

    Article • FEBS Journal, May 2021, Wiley

    Dr Simon McArthur

  15. Analysis of circulating protein aggregates as a route of investigation into neurodegenerative disorders

    Article • Brain Communications, January 2021, Oxford University Press (OUP)

    Dr Simon McArthur

  16. Activation of the pro-resolving receptors Fpr2/3 attenuate lipopolysaccharide-induced inflammatory microglial activation

    Article • July 2020, Cold Spring Harbor Laboratory Press

    Dr Simon McArthur

  17. Reversal of β-Amyloid-Induced Microglial Toxicity In Vitro by Activation of Fpr2/3

    Article • Oxidative Medicine and Cellular Longevity, June 2020, Hindawi Publishing Corporation

    Dr Simon McArthur

  18. Immuno-metabolic impact of the multiple sclerosis patients’ sera on endothelial cells of the blood-brain barrier

    Article • Journal of Neuroinflammation, May 2020, Springer Science + Business Media

    Dr Simon McArthur

  19. Analysis of circulating protein aggregates reveals pathological hallmarks of amyotrophic lateral sclerosis

    Article • May 2020, Cold Spring Harbor Laboratory Press

    Dr Simon McArthur

  20. Reversal of β-amyloid induced microglial toxicity in vitro by activation of Fpr2/3

    Article • February 2020, Cold Spring Harbor Laboratory Press

    Dr Simon McArthur

  21. Annexin A1 drives macrophage skewing to accelerate muscle regeneration through AMPK activation

    Article • Journal of Clinical Investigation, February 2020, American Society for Clinical Investigation

    Dr Simon McArthur

  22. Modeling Cardiac Dysfunction Following Traumatic Hemorrhage Injury: Impact on Myocardial Integrity

    Article • Frontiers in Immunology, December 2019, Frontiers

    Dr Simon McArthur

  23. Desmoglein-3 acts as a pro-survival protein by suppressing reactive oxygen species and doming whilst augmenting the tight junctions in MDCK cells

    Article • Mechanisms of Ageing and Development, December 2019, Elsevier

    Dr Simon McArthur

  24. Estrogen Promotes Pro-resolving Microglial Behavior and Phagocytic Cell Clearance Through the Actions of Annexin A1

    Article • Frontiers in Endocrinology, June 2019, Frontiers

    Dr Simon McArthur

  25. Estrogen promotes pro-resolving microglial behaviour and phagocytic cell clearance through the actions of annexin A1:

    Article • December 2018, Cold Spring Harbor Laboratory Press

    Dr Simon McArthur

  26. Activin subfamily peptides predict chronological age in humans

    Article • Physiological Reports, September 2018, Wiley

    Dr Simon McArthur

  27. Microbiome–host systems interactions: protective effects of propionate upon the blood–brain barrier

    Article • Microbiome, March 2018, Springer Science + Business Media

    Dr Simon McArthur

  28. A chemical produced by gut bacteria can help protect the blood–brain barrier

    Article • July 2017, Cold Spring Harbor Laboratory Press

    Professor Lesley Hoyles, Dr Simon McArthur

  29. The restorative role of annexin A1 at the blood–brain barrier

    Article • Fluids and Barriers of the CNS, September 2016, Springer Science + Business Media

    Dr Simon McArthur

  30. Counteractive effects of antenatal glucocorticoid treatment on D1 receptor modulation of spatial working memory

    Article • Psychopharmacology, August 2016, Springer Science + Business Media

    Dr Simon McArthur

  31. Estrogen protects the blood–brain barrier from inflammation-induced disruption and increased lymphocyte trafficking

    Article • Brain Behavior and Immunity, January 2016, Elsevier

    Dr Simon McArthur

  32. Definition of a Novel Pathway Centered on Lysophosphatidic Acid To Recruit Monocytes during the Resolution Phase of Tissue Inflammation

    Article • The Journal of Immunology, June 2015, The American Association of Immunologists

    Dr Simon McArthur

  33. Sex-specific disruption of murine midbrain astrocytic and dopaminergic developmental trajectories following antenatal GC treatment

    Article • Brain Structure and Function, May 2015, Springer Science + Business Media

    Dr Simon McArthur

  34. Astroglial Plasticity Is Implicated in Hippocampal Remodelling in Adult Rats Exposed to Antenatal Dexamethasone

    Article • Neural Plasticity, January 2015, Hindawi Publishing Corporation

    Dr Simon McArthur

  35. Nonredundant protective properties of FPR2/ALX in polymicrobial murine sepsis

    Article • Proceedings of the National Academy of Sciences, December 2014, Proceedings of the National Academy of Sciences

    Dr Simon McArthur

  36. Sex-dependent diversity in ventral tegmental dopaminergic neurons and developmental programing: A molecular, cellular and behavioral analysis

    Article • Neuroscience, December 2014, Elsevier

    Dr Simon McArthur

  37. Identification of a Novel Recycling Sequence in the C-tail of FPR2/ALX Receptor

    Article • Journal of Biological Chemistry, October 2014, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Simon McArthur

  38. Endogenous annexin A1 is a novel protective determinant in nonalcoholic steatohepatitis in mice

    Article • Hepatology, August 2014, Wolters Kluwer Health

    Dr Simon McArthur

  39. Ligand-specific conformational change of the G-protein–coupled receptor ALX/FPR2 determines proresolving functional responses

    Article • Proceedings of the National Academy of Sciences, October 2013, Proceedings of the National Academy of Sciences

    Dr Simon McArthur

  40. Chemerin15 inhibits neutrophil-mediated vascular inflammation and myocardial ischemia-reperfusion injury through ChemR23

    Article • EMBO Reports, September 2013, Wiley

    Dr Simon McArthur

  41. Antenatal Glucocorticoid Treatment Induces Adaptations in Adult Midbrain Dopamine Neurons, which Underpin Sexually Dimorphic Behavioral Resilience

    Article • Neuropsychopharmacology, August 2013, Nature

    Dr Simon McArthur

  42. Oestrogen and immunomodulation: new mechanisms that impact on peripheral and central immunity

    Article • Current Opinion in Pharmacology, August 2013, Elsevier

    Dr Simon McArthur

  43. Prazosin, an α1-adrenoceptor antagonist, prevents memory deterioration in the APP23 transgenic mouse model of Alzheimer's disease

    Article • Neurobiology of Aging, April 2013, Elsevier

    Dr Simon McArthur

  44. Identification of an essential endogenous regulator of blood–brain barrier integrity, and its pathological and therapeutic implications

    Article • Proceedings of the National Academy of Sciences, December 2012, Proceedings of the National Academy of Sciences

    Dr Simon McArthur

  45. Annexin A1 N-Terminal Derived Peptide Ac2-26 Exerts Chemokinetic Effects on Human Neutrophils

    Article • Frontiers in Pharmacology, January 2012, Frontiers

    Dr Simon McArthur, Prof Jesmond Dalli

  46. Novel Ontogenetic Patterns of Sexual Differentiation in Arcuate Nucleus GHRH Neurons Revealed in GHRH-Enhanced Green Fluorescent Protein Transgenic Mice

    Article • Endocrinology, February 2011, Endocrine Society

    Dr Simon McArthur

  47. Peripheral vs. Central Sex Steroid Hormones in Experimental Parkinson?s Disease

    Article • Frontiers in Endocrinology, January 2011, Frontiers

    Dr Simon McArthur

  48. Annexin A1: A Central Player in the Anti-Inflammatory and Neuroprotective Role of Microglia

    Article • The Journal of Immunology, October 2010, The American Association of Immunologists

    Dr Simon McArthur

  49. Anti-allergic drugs and the Annexin-A1 system

    Article • Pharmacological Reports, May 2010, Elsevier

    Dr Simon McArthur

  50. Estrogen Actions in the Brain and the Basis for Differential Action in Men and Women: A Case for Sex-Specific Medicines

    Article • Pharmacological Reviews, April 2010, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Dr Simon McArthur

  51. Independent influences of sex steroids of systemic and central origin in a rat model of Parkinson's disease: A contribution to sex-specific neuroprotection by estrogens

    Article • Hormones and Behavior, January 2010, Elsevier

    Dr Simon McArthur

  52. Annexin A1 regulates hormone exocytosis through a mechanism involving actin reorganization

    Article • The FASEB Journal, July 2009, Federation of American Societies For Experimental Biology (FASEB)

    Dr Simon McArthur

  53. Cromoglycate drugs suppress eicosanoid generation in U937 cells by promoting the release of Anx-A1

    Article • Biochemical Pharmacology, June 2009, Elsevier

    Dr Simon McArthur

  54. Annexin A1 in the brain – undiscovered roles?

    Article • Trends in Pharmacological Sciences, March 2008, Elsevier

    Dr Simon McArthur, Professor of Pharmacology & Royal Society Wolfson Fellow Felicity N. E. Gavins

  55. Striatal susceptibility to a dopaminergic neurotoxin is independent of sex hormone effects on cell survival and DAT expression but is exacerbated by central aromatase inhibition

    Article • Journal of Neurochemistry, February 2007, Wiley

    Dr Simon McArthur

  56. The Size and Distribution of Midbrain Dopaminergic Populations are Permanently Altered by Perinatal Glucocorticoid Exposure in a Sex- Region- and Time-Specific Manner

    Article • Neuropsychopharmacology, December 2006, Nature

    Dr Simon McArthur

  57. Perinatal Glucocorticoid Treatment Disrupts the Hypothalamo-Lactotroph Axis in Adult Female, But Not Male, Rats

    Article • Endocrinology, April 2006, Endocrine Society

    Dr Simon McArthur

  58. Altered Mesencephalic Dopaminergic Populations in Adulthood as a Consequence of Brief Perinatal Glucocorticoid Exposure

    Article • Journal of Neuroendocrinology, August 2005, Wiley

    Dr Simon McArthur

  59. Sex dimorphisms in the neuroprotective effects of estrogen in an animal model of Parkinson's disease

    Article • Pharmacology Biochemistry and Behavior, July 2004, Elsevier

    Dr Simon McArthur

  60. Dose- and sex-dependent effects of the neurotoxin 6-hydroxydopamine on the nigrostriatal dopaminergic pathway of adult rats: differential actions of estrogen in males and females

    Article • Neuroscience, January 2003, Elsevier

    Dr Simon McArthur