All Stories

  1. SUR1-E1506K mutation impairs glucose tolerance and promotes vulnerable atherosclerotic plaque phenotype in hypercholesterolemic mice

    Article • PLoS ONE, November 2021, PLOS

    Dr Seppo Yla-Herttuala

  2. Inhibition of urothelial carcinoma through targeted type I interferon-mediated immune activation

    Article • OncoImmunology, February 2019, Taylor & Francis

    Dr Seppo Yla-Herttuala

  3. Exosomes as secondary inductive signals involved in kidney organogenesis

    Article • Journal of Extracellular Vesicles, January 2018, Taylor & Francis

    Dr Seppo Yla-Herttuala, Dr Geneviève Bart

  4. Positron Emission Tomography Imaging of Macrophages in Atherosclerosis with 18F-GE-180, a Radiotracer for Translocator Protein (TSPO)

    Article • Contrast Media & Molecular Imaging, January 2018, Hindawi Publishing Corporation

    Dr Seppo Yla-Herttuala

  5. Comparison of viral vectors after intravitreal gene transfer to mouse eye

    Article • Current Gene Therapy, December 2017, Bentham Science Publishers

    Dr Seppo Yla-Herttuala, Emmi Kokki

  6. Adenoviral intramyocardial VEGF-DΔNΔC gene transfer increases myocardial perfusion reserve in refractory angina patients: a phase I/IIa study with 1-year follow-up

    Article • European Heart Journal, July 2017, Oxford University Press (OUP)

    Dr Seppo Yla-Herttuala

  7. Cardiovascular Gene Therapy: Past, Present, and Future

    Article • Molecular Therapy, May 2017, Elsevier

    Dr Seppo Yla-Herttuala

  8. Cardiac Lymphatics – A New Avenue for Therapeutics?

    Article • Trends in Endocrinology and Metabolism, April 2017, Elsevier

    Dr Seppo Yla-Herttuala

  9. Effects of atorvastatin and diet interventions on atherosclerotic plaque inflammation and [ 18 F]FDG uptake in Ldlr −/− Apob 100/100 mice

    Article • Atherosclerosis, April 2017, Elsevier

    Dr Seppo Yla-Herttuala

  10. Low interleukin-2 concentration favors generation of early memory T cells over effector phenotypes during chimeric antigen receptor T-cell expansion

    Article • Cytotherapy, April 2017, Elsevier

    Dr Seppo Yla-Herttuala

  11. High Plasma Lipid Levels Reduce Efficacy of Adenovirus-Mediated Gene Therapy

    Article • Scientific Reports, March 2017, Springer Science + Business Media

    Dr Seppo Yla-Herttuala

  12. Primary and metastatic ovarian cancer: Characterization by 3.0T diffusion-weighted MRI

    Article • European Radiology, March 2017, Springer Science + Business Media

    Dr Seppo Yla-Herttuala

  13. Left ventricular remodeling leads to heart failure in mice with cardiac-specific overexpression of VEGF-B167: echocardiography and magnetic resonance imaging study

    Article • Physiological Reports, March 2017, Wiley

    Dr Seppo Yla-Herttuala

  14. Angiogenic gene therapy in cardiovascular diseases: dream or vision?

    Article • European Heart Journal, January 2017, European Society of Cardiology

    Dr Seppo Yla-Herttuala

  15. Peroxisome proliferator-activated receptor-γ coactivator 1 α1 induces a cardiac excitation-contraction coupling phenotype without metabolic remodelling

    Article • The Journal of Physiology, December 2016, Wiley

    Dr Seppo Yla-Herttuala

  16. Differential regulation of angiogenic cellular processes and claudin-5 by histamine and VEGF via PI3K-signaling, transcription factor SNAI2 and interleukin-8

    Article • Angiogenesis, November 2016, Springer Science + Business Media

    Dr Seppo Yla-Herttuala

  17. Angiogenesis of ovarian cancer: characterization by 3.0t diffusion weighted MRI

    Article • European Journal of Obstetrics & Gynecology and Reproductive Biology, November 2016, Elsevier

    Dr Seppo Yla-Herttuala

  18. Leukocyte trafficking-associated vascular adhesion protein 1 is expressed and functionally active in atherosclerotic plaques

    Article • Scientific Reports, October 2016, Nature

    Dr Seppo Yla-Herttuala

  19. Writing the Next Chapter for the Molecular Therapy Family of Journals

    Article • Molecular Therapy, October 2016, Elsevier

    Dr Seppo Yla-Herttuala

  20. Intramyocardial Gene Therapy Directed to Hibernating Heart Muscle Using a Combination of Electromechanical Mapping and Positron Emission Tomography

    Article • Human Gene Therapy, October 2016, Mary Ann Liebert Inc

    Dr Seppo Yla-Herttuala

  21. In vivo phage display screening for tumor vascular targets in glioblastoma identifies a llama nanobody against dynactin-1-p150Glued

    Article • Oncotarget, September 2016, Impact Journals, LLC

    Dr Seppo Yla-Herttuala

  22. Tie1 controls angiopoietin function in vascular remodeling and inflammation

    Article • Journal of Clinical Investigation, August 2016, American Society for Clinical Investigation

    Dr Seppo Yla-Herttuala

  23. Isoform-Specific Modulation of Inflammation Induced by Adenoviral Mediated Delivery of Platelet-Derived Growth Factors in the Adult Mouse Heart

    Article • PLoS ONE, August 2016, PLOS

    Dr Seppo Yla-Herttuala

  24. Endothelial PDGF-CC regulates angiogenesis-dependent thermogenesis in beige fat

    Article • Nature Communications, August 2016, Nature

    Dr Seppo Yla-Herttuala

  25. Call for papers: Nanoparticle Development and Applications in Cellular and Molecular Therapies

    Article • Molecular Therapy, August 2016, Elsevier

    Dr Seppo Yla-Herttuala, Dr. Ernst Wagner

  26. Debate on Germline Gene Editing

    Article • Human Gene Therapy Methods, August 2016, Mary Ann Liebert Inc

    Dr Seppo Yla-Herttuala

  27. Smooth Muscle Cell Foam Cell Formation, Apolipoproteins, and ABCA1 in Intracranial Aneurysms: Implications for Lipid Accumulation as a Promoter of Aneurysm Wall Rupture

    Article • Journal of Neuropathology & Experimental Neurology, June 2016, Oxford University Press (OUP)

    Dr Seppo Yla-Herttuala

  28. Activation of Peroxisome Proliferator–Activated Receptor-δ as Novel Therapeutic Strategy to Prevent In-Stent Restenosis and Stent ThrombosisHighlights

    Article • Arteriosclerosis Thrombosis and Vascular Biology, June 2016, Wolters Kluwer Health

    Dr Seppo Yla-Herttuala, Dr Jörg-Detlef Drenckhahn

  29. ADA-SCID Gene Therapy Endorsed By European Medicines Agency For Marketing Authorization

    Article • Molecular Therapy, June 2016, Elsevier

    Dr Seppo Yla-Herttuala

  30. 18-kDa translocator protein ligand 18F-FEMPA: Biodistribution and uptake into atherosclerotic plaques in mice

    Article • Journal of Nuclear Cardiology, May 2016, Springer Science + Business Media

    Dr Seppo Yla-Herttuala

  31. AdVEGF-B 186 and AdVEGF-D ΔNΔC induce angiogenesis and increase perfusion in porcine myocardium

    Article • Heart, May 2016, BMJ

    Dr Seppo Yla-Herttuala

  32. 461. The Testing Strategy to Determine the Pharmacological Activity of Gene Therapy Drug Product (rAd-IFN) to Treat Intravesical Non-Muscle Invasive Bladder Cancer

    Article • Molecular Therapy, May 2016, Elsevier

    Dr Seppo Yla-Herttuala

  33. 706. Consistent Viral Vector Manufacturing for Phase III Using iCELLis 500 Fixed-Bed Technology

    Article • Molecular Therapy, May 2016, Elsevier

    Dr Seppo Yla-Herttuala

  34. CardioPulse ArticlesLeaders in cardiovascular medicineGöran K. Hansson: Sweden's statesman of scienceRegenerative medicine in the practice of cardiologyTranslational research in cardiovascular diseaseProgress in gene therapy for cardiovascular diseaseG...

    Article • European Heart Journal, April 2016, European Society of Cardiology

    Dr Seppo Yla-Herttuala

  35. Sleeping Beauty Transposon Vectors in Liver-directed Gene Delivery of LDLR and VLDLR for Gene Therapy of Familial Hypercholesterolemia

    Article • Molecular Therapy, March 2016, Elsevier

    Tytteli Turunen, Dr Seppo Yla-Herttuala

  36. Expression of vascular endothelial growth factor (VEGF)-B and its receptor (VEGFR1) in murine heart, lung and kidney

    Article • Cell and Tissue Research, March 2016, Springer Science + Business Media

    Dr Seppo Yla-Herttuala

  37. Type 2 diabetes enhances arterial uptake of choline in atherosclerotic mice: an imaging study with positron emission tomography tracer 18F-fluoromethylcholine

    Article • Cardiovascular Diabetology, February 2016, Springer Science + Business Media

    Dr Seppo Yla-Herttuala

  38. Platelet-derived Growth Factor-B Protects Rat Cardiac Allografts From Ischemia-reperfusion Injury

    Article • Transplantation, February 2016, Wolters Kluwer Health

    Dr Seppo Yla-Herttuala

  39. Animal Models of Gene Therapy for Cardiovascular Disease

    Article • January 2016, Elsevier

    Dr Seppo Yla-Herttuala

  40. Development of Lentiviral Vectors for Targeted Integration and Protein Delivery

    Article • January 2016, Springer Science + Business Media

    Dr Seppo Yla-Herttuala

  41. Efficacy and safety of myocardial gene transfer of adenovirus, adeno-associated virus and lentivirus vectors in the mouse heart

    Article • Gene Therapy, December 2015, Nature

    Dr Seppo Yla-Herttuala

  42. Mouse ECG findings in aging, with conduction system affecting drugs and in cardiac pathologies: Development and validation of ECG analysis algorithm in mice

    Article • Physiological Reports, December 2015, Wiley

    Dr Seppo Yla-Herttuala

  43. Gene Therapy for Heart Failure: Back to the Bench

    Article • Molecular Therapy, October 2015, Elsevier

    Dr Seppo Yla-Herttuala

  44. Prospect and progress of gene therapy in treating atherosclerosis

    Article • Expert Opinion on Biological Therapy, August 2015, Informa Healthcare

    Dr Seppo Yla-Herttuala

  45. Molecular Therapy Special Issue on Gene Editing Technologies and Applications

    Article • Molecular Therapy, August 2015, Elsevier

    Dr Seppo Yla-Herttuala

  46. Gene Therapy in Nordic Countries

    Article • Human Gene Therapy, August 2015, Mary Ann Liebert Inc

    Dr Seppo Yla-Herttuala

  47. Recent Advancements in Cardiovascular Gene Therapy and Vascular Biology

    Article • Human Gene Therapy, August 2015, Mary Ann Liebert Inc

    Dr Seppo Yla-Herttuala

  48. Angiopoietin-2 blocking antibodies reduce early atherosclerotic plaque development in mice

    Article • Atherosclerosis, August 2015, Elsevier

    Dr Seppo Yla-Herttuala

  49. Process Development of Adenoviral Vector Production in Fixed Bed Bioreactor: From Bench to Commercial Scale

    Article • Human Gene Therapy, August 2015, Mary Ann Liebert Inc

    Dr Seppo Yla-Herttuala

  50. Transplantation of adipose tissue mesenchymal cells conjugated with VEGF-releasing microcarriers promotes repair in murine myocardial infarction

    Article • Cardiovascular Research, July 2015, European Society of Cardiology

    Professor Raffaele De Caterina, Dr Seppo Yla-Herttuala

  51. High plasma lipid levels inhibit transgene expression in adenovirus-mediated gene therapy

    Article • Atherosclerosis, July 2015, Elsevier

    Dr Seppo Yla-Herttuala

  52. Differential Promoter Methylation of Macrophage Genes Is Associated With Impaired Vascular Growth in Ischemic Muscles of Hyperlipidemic and Type 2 Diabetic MiceNovelty and Significance

    Article • Circulation Research, June 2015, Wolters Kluwer Health

    Dr Seppo Yla-Herttuala

  53. Growth factor therapy and lymph node graft for lymphedema

    Article • Journal of Surgical Research, June 2015, Elsevier

    Dr Pauliina Hartiala, Dr Seppo Yla-Herttuala

  54. VEGF-C and VEGF-C156S in the pro-lymphangiogenic growth factor therapy of lymphedema: a large animal study

    Article • Angiogenesis, May 2015, Springer Science + Business Media

    Dr Seppo Yla-Herttuala

  55. Slit2 modifies VEGF-induced angiogenic responses in rabbit skeletal muscle via reduced eNOS activity

    Article • Cardiovascular Research, May 2015, European Society of Cardiology

    Dr Seppo Yla-Herttuala

  56. 672. iCELLisTM Fixed-Bed Technology for Adherent Cells Is an Efficient Scalable System for Viral Vector Production Applications

    Article • Molecular Therapy, May 2015, Elsevier

    Dr Seppo Yla-Herttuala

  57. Baculovirus-mediated Gene Delivery and RNAi Applications

    Article • Viruses, April 2015, MDPI AG

    Dr Seppo Yla-Herttuala

  58. Apolipoprotein A-I mimetic peptide 4F blocks sphingomyelinase-induced LDL aggregation

    Article • Journal of Lipid Research, April 2015, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Seppo Yla-Herttuala, Dr Katariina Öörni

  59. From the Impact Factor to DORA and the Scientific Content of Articles

    Article • Molecular Therapy, April 2015, Elsevier

    Dr Seppo Yla-Herttuala

  60. Mo1839 A Leaky Colonic Vascular Barrier Caused by Clostridium difficile Toxins A and B Contributes to the Pathogenesis of C. difficile Infection

    Article • Gastroenterology, April 2015, Elsevier

    Dr Seppo Yla-Herttuala

  61. PDGF-B Is Protective During Ischemia-Reperfusion Injury in Rat Cardiac Allografts

    Article • The Journal of Heart and Lung Transplantation, April 2015, Elsevier

    Dr Seppo Yla-Herttuala

  62. Glybera's Second Act: The Curtain Rises on the High Cost of Therapy

    Article • Molecular Therapy, February 2015, Elsevier

    Dr Seppo Yla-Herttuala

  63. Tomato thymidine kinase-based suicide gene therapy for malignant glioma—an alternative for Herpes Simplex virus-1 thymidine kinase

    Article • Cancer Gene Therapy, January 2015, Nature

    Dr Seppo Yla-Herttuala

  64. PDGF-B is Protective during Ischemia-reperfusion Injury in Rat Cardiac Allografts

    Article • The Thoracic and Cardiovascular Surgeon, January 2015, Thieme Publishing Group

    Dr Seppo Yla-Herttuala

  65. Baculovirus: A High-Capacity Vector for Versatile Gene Transfer

    Article • January 2015, Taylor & Francis

    Dr Seppo Yla-Herttuala

  66. Regulation of VEGF-A Expression in Endothelial Cells by Transcriptional Gene Activation or Transcriptional Gene Silencing: Analysis of Genome Wide Transcriptional Response

    Article • Gene Technology, January 2015, OMICS Publishing Group

    PhD Mikko P Turunen, Dr Seppo Yla-Herttuala

  67. The Molecular Therapy Family: Past, Present, and Future

    Article • Molecular Therapy, January 2015, Elsevier

    Dr Seppo Yla-Herttuala

  68. Differential Regulation of Vascular Endothelial Growth Factors by Promoter-targeted shRNAs

    Article • Molecular Therapy — Nucleic Acids, January 2015, Elsevier

    Dr Seppo Yla-Herttuala

  69. Hyperbaric oxygen therapy activates hypoxia-inducible factor 1 (HIF-1), which contributes to improved wound healing in diabetic mice

    Article • Wound Repair and Regeneration, January 2015, Wiley

    Dr Seppo Yla-Herttuala

  70. Animal Models of Diabetic Macrovascular Complications: Key Players in the Development of New Therapeutic Approaches

    Article • Journal of Diabetes Research, January 2015, Hindawi Publishing Corporation

    Dr Seppo Yla-Herttuala

  71. Novel Nuclear Biology of Small Non-Coding RNAs

    Article • Gene Technology, January 2015, OMICS Publishing Group

    Dr Seppo Yla-Herttuala

  72. Global DNA methylation analysis of human atherosclerotic plaques reveals extensive genomic hypomethylation and reactivation at imprinted locus 14q32 involving induction of a miRNA cluster

    Article • European Heart Journal, November 2014, European Society of Cardiology

    Dr Seppo Yla-Herttuala

  73. Soluble Vascular Endothelial Growth Factor Receptor-1 Improves Therapeutic Efficacy of Suicide Gene Therapy in an Angiogenesis-Independent Manner

    Article • Human Gene Therapy, November 2014, Mary Ann Liebert Inc

    Dr Seppo Yla-Herttuala

  74. [18F]Fluorodeoxyglucose Uptake in Atherosclerotic Plaques Is Associated With Reduced Coronary Flow Reserve in Mice

    Article • Journal of Ultrasound in Medicine, November 2014, Wiley

    Dr Seppo Yla-Herttuala

  75. Control of VEGF-A transcriptional programs by pausing and genomic compartmentalization

    Article • Nucleic Acids Research, October 2014, Oxford University Press (OUP)

    Dr Seppo Yla-Herttuala

  76. Brain Pharmacokinetics of Ganciclovir in Rats with Orthotopic BT4C Glioma

    Article • Drug Metabolism and Disposition, October 2014, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Dr Seppo Yla-Herttuala

  77. HIF-1α and HIF-2α induce angiogenesis and improve muscle energy recovery

    Article • European Journal of Clinical Investigation, September 2014, Wiley

    Dr Seppo Yla-Herttuala

  78. 14q32 miRNA Cluster Takes Center Stage in Neovascularization

    Article • Circulation Research, September 2014, Wolters Kluwer Health

    Dr Seppo Yla-Herttuala

  79. Serum angiopoietin-2 and soluble VEGFR-2 levels predict malignancy of ovarian neoplasm and poor prognosis in epithelial ovarian cancer

    Article • BMC Cancer, September 2014, Springer Science + Business Media

    Dr Seppo Yla-Herttuala

  80. Clonal variation in interferon response determines the outcome of oncolytic virotherapy in mouse CT26 colon carcinoma model

    Article • Gene Therapy, September 2014, Nature

    Dr Seppo Yla-Herttuala

  81. Lack of cardiac and high-fat diet induced metabolic phenotypes in two independent strains of Vegf-b knockout mice

    Article • Scientific Reports, August 2014, Nature

    Dr Seppo Yla-Herttuala

  82. Ultrasound imaging with bolus delivered contrast agent for the detection of angiogenesis and blood flow irregularities

    Article • AJP Heart and Circulatory Physiology, August 2014, American Physiological Society

    Dr Seppo Yla-Herttuala

  83. P198Chronic, atherosclerosis-like ischemia model in hypercholesterolemic rabbits reveals a challenge for angiogenic gene therapy

    Article • Cardiovascular Research, June 2014, European Society of Cardiology

    Dr Seppo Yla-Herttuala

  84. P199The muscle recovery potential of vegf gene therapy in a mouse model of hindlimb ischemia

    Article • Cardiovascular Research, June 2014, European Society of Cardiology

    Dr Seppo Yla-Herttuala

  85. Feasibility of experimental BT4C glioma models for somatostatin receptor 2-targeted therapies

    Article • Acta Oncologica, June 2014, Informa Healthcare

    Dr Seppo Yla-Herttuala

  86. Lymphatic Vessel Insufficiency in Hypercholesterolemic Mice Alters Lipoprotein Levels and Promotes Atherogenesis

    Article • Arteriosclerosis Thrombosis and Vascular Biology, April 2014, Wolters Kluwer Health

    Dr Seppo Yla-Herttuala

  87. Gene Therapy Used in Cancer Treatment

    Article • Biomedicines, April 2014, MDPI AG

    Dr Seppo Yla-Herttuala

  88. Reply to "Heparan Sulfate in Baculovirus Binding and Entry of Mammalian Cells"

    Article • Journal of Virology, March 2014, ASM Journals

    Dr Seppo Yla-Herttuala

  89. Does Nrf2 Gene Transfer Facilitate Recovery After Contusion Spinal Cord Injury?

    Article • Antioxidants & Redox Signaling, March 2014, Mary Ann Liebert Inc

    Dr Seppo Yla-Herttuala

  90. Epigenetic Upregulation of Endogenous VEGF-A Reduces Myocardial Infarct Size in Mice

    Article • PLoS ONE, February 2014, PLOS

    PhD Mikko P Turunen, Dr Seppo Yla-Herttuala

  91. Analysis of Fat Graft Metabolic Adaptation and Vascularization Using Positron Emission Tomography–Computed Tomographic Imaging

    Article • Plastic & Reconstructive Surgery, February 2014, Wolters Kluwer Health

    Dr Pauliina Hartiala, Dr Seppo Yla-Herttuala

  92. Does mass balance between sense and antisense transcripts fine‐tune the outcome of gene expression?

    Article • EMBO Reports, January 2014, EMBO

    Dr Seppo Yla-Herttuala

  93. Current gene therapy trials for vascular diseases

    Article • Expert Opinion on Biological Therapy, January 2014, Informa Healthcare

    Dr Seppo Yla-Herttuala

  94. Sleeping Beauty-baculovirus hybrid vectors for long-term gene expression in the eye

    Article • The Journal of Gene Medicine, January 2014, Wiley

    Tytteli Turunen, Dr Seppo Yla-Herttuala

  95. A New Gene Therapy Approach for Cardiovascular Disease by Non-coding RNAs Acting in the Nucleus

    Article • Molecular Therapy — Nucleic Acids, January 2014, Elsevier

    PhD Mikko P Turunen, Dr Seppo Yla-Herttuala

  96. Biodistribution and antitumor effect of Cetuximab-targeted lentivirus

    Article • Nuclear Medicine and Biology, January 2014, Elsevier

    Dr Seppo Yla-Herttuala

  97. Gene transfer vectors (DNA vehicles) and their incorporation into biomaterials for bone repair

    Article • January 2014, Elsevier

    Dr Seppo Yla-Herttuala

  98. Lentiviral Protein Transduction with Genome-Modifying HIV-1 Integrase-I-PpoI Fusion Proteins: Studies on Specificity and Cytotoxicity

    Article • BioMed Research International, January 2014, Hindawi Publishing Corporation

    Dr Seppo Yla-Herttuala

  99. The impact of the receptor binding profiles of the vascular endothelial growth factors on their angiogenic features

    Article • Biochimica et Biophysica Acta (BBA) - General Subjects, January 2014, Elsevier

    Dr Seppo Yla-Herttuala

  100. Modified RNA kick-starts cardiac repair

    Article • Nature Biotechnology, October 2013, Nature

    Dr Seppo Yla-Herttuala

  101. Hypoxia-inducible factor 1-induced G protein-coupled receptor 35 expression is an early marker of progressive cardiac remodelling

    Article • Cardiovascular Research, October 2013, European Society of Cardiology

    Dr Seppo Yla-Herttuala

  102. Epigenetic regulation in vascular cells

    Article • Current Opinion in Lipidology, October 2013, Wolters Kluwer Health

    PhD Mikko P Turunen, Dr Seppo Yla-Herttuala

  103. The Genetic and Metabolic Determinants of Cardiovascular Complications in Type 2 Diabetes: Recent Insights from Animal Models and Clinical Investigations

    Article • Canadian Journal of Diabetes, October 2013, Elsevier

    Dr Seppo Yla-Herttuala

  104. Improved therapeutic effect on malignant glioma with adenoviral suicide gene therapy combined with temozolomide

    Article • Gene Therapy, September 2013, Nature

    Dr Seppo Yla-Herttuala

  105. The bottleneck stent model for chronic myocardial ischemia and heart failure in pigs

    Article • AJP Heart and Circulatory Physiology, August 2013, American Physiological Society

    Dr Seppo Yla-Herttuala

  106. Stabilization of atherosclerotic plaques: an update

    Article • European Heart Journal, August 2013, European Society of Cardiology

    Dr Seppo Yla-Herttuala

  107. 6-O- and N-Sulfated Syndecan-1 Promotes Baculovirus Binding and Entry into Mammalian Cells

    Article • Journal of Virology, August 2013, ASM Journals

    Dr Seppo Yla-Herttuala

  108. Research update for articles published in EJCI in 2011

    Article • European Journal of Clinical Investigation, August 2013, Wiley

    Dr Seppo Yla-Herttuala

  109. Blocking lymphatic vessel function with soluble VEGFR3 in atherosclerotic mouse model alters lipoprotein metabolism and enhances atherogenesis

    Article • European Heart Journal, August 2013, European Society of Cardiology

    Dr Seppo Yla-Herttuala

  110. The effects of VEGF-A on atherosclerosis, lipoprotein profile and lipoprotein lipase in hyperlipidemic mouse models

    Article • European Heart Journal, August 2013, European Society of Cardiology

    Dr Seppo Yla-Herttuala

  111. Gene transfer using vammin induces robust angiogenesis and increases ejection fraction in ischemic porcine myocardium

    Article • European Heart Journal, August 2013, European Society of Cardiology

    Dr Seppo Yla-Herttuala

  112. Cardiovascular gene therapy with vascular endothelial growth factors

    Article • Gene, August 2013, Elsevier

    Dr Seppo Yla-Herttuala

  113. Adenovirus-mediated gene therapy with sitimagene ceradenovec followed by intravenous ganciclovir for patients with operable high-grade glioma (ASPECT): a randomised, open-label, phase 3 trial

    Article • The Lancet Oncology, August 2013, Elsevier

    Dr Seppo Yla-Herttuala

  114. History of gene therapy

    Article • Gene, August 2013, Elsevier

    Dr Seppo Yla-Herttuala

  115. Phosphorylation Regulates FOXC2-Mediated Transcription in Lymphatic Endothelial Cells

    Article • Molecular and Cellular Biology, July 2013, ASM Journals

    Dr Seppo Yla-Herttuala

  116. Cell Susceptibility to Baculovirus Transduction and Echovirus Infection Is Modified by Protein Kinase C Phosphorylation and Vimentin Organization

    Article • Journal of Virology, July 2013, ASM Journals

    Dr Seppo Yla-Herttuala

  117. Distinct metabolic and vascular effects of dietary triglycerides and cholesterol in atherosclerotic and diabetic mouse models

    Article • AJP Endocrinology and Metabolism, July 2013, American Physiological Society

    Dr Seppo Yla-Herttuala

  118. The effects of VEGF-A on atherosclerosis, lipoprotein profile, and lipoprotein lipase in hyperlipidaemic mouse models

    Article • Cardiovascular Research, June 2013, European Society of Cardiology

    Dr Seppo Yla-Herttuala

  119. Lymph Node Transfer and Perinodal Lymphatic Growth Factor Treatment for Lymphedema

    Article • Annals of Surgery, May 2013, Wolters Kluwer Health

    Dr Seppo Yla-Herttuala

  120. Efficient Pro-survival/angiogenic miRNA Delivery by an MRI-Detectable Nanomaterial

    Article • ACS Nano, April 2013, American Chemical Society (ACS)

    PhD Mikko P Turunen, Dr Seppo Yla-Herttuala

  121. Therapeutic gene targeting approaches for the treatment of dyslipidemias and atherosclerosis

    Article • Current Opinion in Lipidology, April 2013, Wolters Kluwer Health

    Dr Seppo Yla-Herttuala

  122. Baculovirus: an Insect-derived Vector for Diverse Gene Transfer Applications

    Article • Molecular Therapy, April 2013, Elsevier

    Dr Seppo Yla-Herttuala

  123. General principles and approaches of gene therapy

    Article • March 2013, Future Medicine

    Dr Seppo Yla-Herttuala

  124. Preclinical Safety, Toxicology, and Biodistribution Study of Adenoviral Gene Therapy with sVEGFR-2 and sVEGFR-3 Combined with Chemotherapy for Ovarian Cancer

    Article • Human Gene Therapy Clinical Development, March 2013, Mary Ann Liebert Inc

    Dr Seppo Yla-Herttuala

  125. Promoting blood vessel growth in ischemic diseases: challenges in translating preclinical potential into clinical success

    Article • Disease Models & Mechanisms, February 2013, The Company of Biologists

    Dr Seppo Yla-Herttuala

  126. Vascular Endothelial Growth Factor-Angiopoietin Chimera With Improved Properties for Therapeutic Angiogenesis

    Article • Circulation, January 2013, Wolters Kluwer Health

    Dr Seppo Yla-Herttuala, Dr Michael Jeltsch

  127. The absence of macrophage Nrf2 promotes early atherogenesis

    Article • Cardiovascular Research, January 2013, European Society of Cardiology

    Dr Seppo Yla-Herttuala

  128. The Lymphatics in Normal and Pathological Heart Valves

    Article • January 2013, Springer Science + Business Media

    Dr Seppo Yla-Herttuala

  129. Lipid accumulation, lipid oxidation, and low plasma levels of acquired antibodies against oxidized lipids associate with degeneration and rupture of the intracranial aneurysm wall

    Article • Acta Neuropathologica Communications, January 2013, Springer Science + Business Media

    Dr Seppo Yla-Herttuala

  130. Arteriogenic therapy based on simultaneous delivery of VEGF-A and FGF4 genes improves the recovery from acute limb ischemia

    Article • Vascular Cell, January 2013, Publiverse Online S.R.L

    Dr Seppo Yla-Herttuala

  131. Computed tomographic coronary angiography for patients with heart failure (CTA-HF): a randomized controlled trial (IMAGE HF Project 1-C)

    Article • Current Controlled Trials in Cardiovascular Medicine, January 2013, Springer Science + Business Media

    Dr Seppo Yla-Herttuala

  132. Functional MRI Measurements to Predict Early Adenoviral Gene Therapy Response in Ovarian Cancer Mouse Model

    Article • Journal of Genetic Syndromes & Gene Therapy, January 2013, OMICS Publishing Group

    Dr Seppo Yla-Herttuala

  133. Intramyocardial Adenovirus-Mediated VEGF-DΔNΔC Gene Transfer in Patients with No-Option Coronary Artery Disease: Interim Safety Analysis of the Kuopio Angiogenesis Trial 301

    Article • International Journal of Cardiovascular Research, January 2013, OMICS Publishing Group

    Dr Seppo Yla-Herttuala

  134. Routine versus selective cardiac magnetic resonance in non-ischemic heart failure – OUTSMART-HF: study protocol for a randomized controlled trial (IMAGE-HF (heart failure) project 1-B)

    Article • Current Controlled Trials in Cardiovascular Medicine, January 2013, Springer Science + Business Media

    Dr Seppo Yla-Herttuala

  135. rDNA-directed integration by an HIV-1 integrase--I-PpoI fusion protein

    Article • Nucleic Acids Research, December 2012, Oxford University Press (OUP)

    Dr Seppo Yla-Herttuala

  136. European Perspectives

    Article • Circulation, December 2012, Wolters Kluwer Health

    Dr Seppo Yla-Herttuala

  137. AAV9-mediated VEGF-B Gene Transfer Improves Systolic Function in Progressive Left Ventricular Hypertrophy

    Article • Molecular Therapy, December 2012, Elsevier

    Dr Seppo Yla-Herttuala

  138. Targeted delivery via avidin fusion protein: Intracellular fate of biotinylated doxorubicin derivative and cellular uptake kinetics and biodistribution of biotinylated liposomes

    Article • European Journal of Pharmaceutical Sciences, December 2012, Elsevier

    Dr Seppo Yla-Herttuala, David Selwood

  139. Regulation of endothelial lipase and systemic HDL cholesterol levels by SREBPs and VEGF-A

    Article • Atherosclerosis, December 2012, Elsevier

    Dr Seppo Yla-Herttuala

  140. Critical Role of VEGF-C/VEGFR-3 Signaling in Innate and Adaptive Immune Responses in Experimental Obliterative Bronchiolitis

    Article • American Journal Of Pathology, November 2012, Elsevier

    Dr Seppo Yla-Herttuala, Dr Michael Jeltsch

  141. 02 Nanoparticles for Simultaneous Cell Tracking & Microrna Delivery

    Article • Heart, November 2012, BMJ

    Dr Seppo Yla-Herttuala

  142. Increased invasion of malignant gliomas after 15-LO-1 and HSV-tk/ganciclovir combination gene therapy

    Article • Cancer Gene Therapy, October 2012, Nature

    Dr Seppo Yla-Herttuala

  143. Dotted collar placed around carotid artery induces asymmetric neointimal lesion formation in rabbits without intravascular manipulations

    Article • BMC Cardiovascular Disorders, October 2012, Springer Science + Business Media

    Dr Seppo Yla-Herttuala

  144. Oxidative Stress-Regulated Lentiviral TK/GCV Gene Therapy for Lung Cancer Treatment

    Article • Cancer Research, October 2012, American Association for Cancer Research (AACR)

    Dr Seppo Yla-Herttuala

  145. Endgame: Glybera Finally Recommended for Approval as the First Gene Therapy Drug in the European Union

    Article • Molecular Therapy, October 2012, Elsevier

    Dr Seppo Yla-Herttuala

  146. Neuropilin-2 and vascular endothelial growth factor receptor-3 are up-regulated in human vascular malformations

    Article • Angiogenesis, September 2012, Springer Science + Business Media

    Dr Seppo Yla-Herttuala

  147. Longitudinal rotating frame relaxation time measurements in infarcted mouse myocardium in vivo

    Article • Magnetic Resonance in Medicine, June 2012, Wiley

    Dr Seppo Yla-Herttuala

  148. VEGF gene transfer: From basic science to clinical applications

    Article • Vascular Pharmacology, May 2012, Elsevier

    Dr Seppo Yla-Herttuala

  149. The Syngeneic BT4C Rat Malignant Glioma is a Valuable Model to Study Myelomonocytic Cells in Tumors

    Article • Cancer Growth and Metastasis, May 2012, Libertas Academica, Ltd.

    Dr Seppo Yla-Herttuala

  150. Conditional expression of Lodavin, an avidin-tagged LDL receptor, for biotin-mediated applications in vivo

    Article • genesis, April 2012, Wiley

    Dr Seppo Yla-Herttuala

  151. Diet intervention reduces uptake of αvβ3 integrin-targeted PET tracer 18F-galacto-RGD in mouse atherosclerotic plaques

    Article • Journal of Nuclear Cardiology, April 2012, Springer Science + Business Media

    Dr Seppo Yla-Herttuala

  152. Efficient gene therapy based targeting system for the treatment of inoperable tumors

    Article • The Journal of Gene Medicine, April 2012, Wiley

    Dr Seppo Yla-Herttuala

  153. Gene Therapy for Cardiovascular Diseases

    Article • March 2012, Bentham Science Publishers

    Dr Seppo Yla-Herttuala

  154. Antiangiogenic gene therapy with soluble VEGF‐receptors ‐1, ‐2 and ‐3 together with paclitaxel prolongs survival of mice with human ovarian carcinoma

    Article • International Journal of Cancer, March 2012, Wiley

    Dr Seppo Yla-Herttuala

  155. Low-grade inflammation and the phenotypic expression of myocardial fibrosis in hypertrophic cardiomyopathy

    Article • Heart, March 2012, BMJ

    Dr Seppo Yla-Herttuala

  156. In Vitro Targeting of Avidin-Expressing Glioma Cells with Biotinylated Persistent Luminescence Nanoparticles

    Article • Bioconjugate Chemistry, March 2012, American Chemical Society (ACS)

    Dr Seppo Yla-Herttuala

  157. The Need for Increased Clarity and Transparency in the Regulatory Pathway for Gene Medicines in the European Union

    Article • Molecular Therapy, March 2012, Elsevier

    Dr Seppo Yla-Herttuala

  158. Endothelium-specific overexpression of human vascular endothelial growth factor-D in mice leads to increased tumor frequency and a reduced lifespan

    Article • The Journal of Gene Medicine, March 2012, Wiley

    Dr Seppo Yla-Herttuala

  159. Effects of Angiopoietin-2-Blocking Antibody on Endothelial Cell-Cell Junctions and Lung Metastasis

    Article • JNCI Journal of the National Cancer Institute, February 2012, Oxford University Press (OUP)

    Dr Seppo Yla-Herttuala

  160. Baculovirus‐mediated vascular endothelial growth factor‐DΔNΔC gene transfer induces angiogenesis in rabbit skeletal muscle

    Article • The Journal of Gene Medicine, January 2012, Wiley

    Dr Seppo Yla-Herttuala

  161. Epigenetics and Atherosclerosis

    Article • January 2012, Springer Science + Business Media

    PhD Mikko P Turunen, Dr Seppo Yla-Herttuala

  162. Gene therapy in age related macular degeneration and hereditary macular disorders

    Article • Frontiers in Bioscience, January 2012, Frontiers in Bioscience

    Dr Seppo Yla-Herttuala

  163. Specific Inhibition of SRC Kinase Impairs Malignant Glioma Growth In Vitro and In Vivo

    Article • Molecular Therapy — Nucleic Acids, January 2012, Elsevier

    Dr Seppo Yla-Herttuala

  164. Intracardiac injection of a capsid-modified Ad5/35 results in decreased heart toxicity when compared to standard Ad5

    Article • Virology Journal, January 2012, Springer Science + Business Media

    Dr Seppo Yla-Herttuala

  165. Heme oxygenase 1 is induced by miR-155 via reduced BACH1 translation in endothelial cells

    Article • Free Radical Biology and Medicine, December 2011, Elsevier

    Dr Seppo Yla-Herttuala

  166. Effects of Age, Diet, and Type 2 Diabetes on the Development and FDG Uptake of Atherosclerotic Plaques

    Article • JACC Cardiovascular Imaging, December 2011, Elsevier

    Dr Seppo Yla-Herttuala

  167. Novel insights into the regulation of antioxidant-response-elementmediated gene expression by electrophiles: induction of the transcriptional repressor BACH1 by Nrf2

    Article • Biochemical Journal, December 2011, Portland Press Ltd.

    Dr Seppo Yla-Herttuala

  168. Corrigendum to “Primary effect of 1α,25(OH)2D3 on IL-10 expression in monocytes is short-term down-regulation” [Biochim. Biophys. Acta 1803 (2010) 1276–86]

    Article • Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, December 2011, Elsevier

    Dr Seppo Yla-Herttuala

  169. Pro- and anti-angiogenic therapy and atherosclerosis with special emphasis on vascular endothelial growth factors

    Article • Expert Opinion on Biological Therapy, November 2011, Informa Healthcare

    Dr Seppo Yla-Herttuala

  170. Epigenetic Epidemiology of Atherosclerosis

    Article • November 2011, Springer Science + Business Media

    PhD Mikko P Turunen, Dr Seppo Yla-Herttuala

  171. Adventitial gene transfer of VEGFR-2 specific VEGF-E chimera induces MCP-1 expression in vascular smooth muscle cells and enhances neointimal formation

    Article • Atherosclerosis, November 2011, Elsevier

    Dr Seppo Yla-Herttuala

  172. VEGFR-3 controls tip to stalk conversion at vessel fusion sites by reinforcing Notch signalling

    Article • Nature, September 2011, Nature

    Dr Seppo Yla-Herttuala

  173. Gene Therapy of Glioblastoma Multiforme - Clinical Experience on the Use of Adenoviral Vectors

    Article • August 2011, IntechOpen

    Dr Seppo Yla-Herttuala

  174. 10-year safety follow-up in patients with local VEGF gene transfer to ischemic lower limb

    Article • Gene Therapy, July 2011, Nature

    Dr Seppo Yla-Herttuala

  175. How to avoid complement attack in baculovirus-mediated gene delivery

    Article • Journal of Invertebrate Pathology, July 2011, Elsevier

    Dr Seppo Yla-Herttuala

  176. Requirements for baculoviruses for clinical gene therapy applications

    Article • Journal of Invertebrate Pathology, July 2011, Elsevier

    Dr Seppo Yla-Herttuala

  177. Baculoviruses as gene therapy vectors for human prostate cancer

    Article • Journal of Invertebrate Pathology, July 2011, Elsevier

    Dr Seppo Yla-Herttuala

  178. Glioma cell density in a rat gene therapy model gauged by water relaxation rate along a fictitious magnetic field

    Article • Magnetic Resonance in Medicine, June 2011, Wiley

    Dr Seppo Yla-Herttuala

  179. Resectable VX-2 rabbit brain tumor model for development of intraoperative local administration of drugs

    Article • Acta Neurochirurgica, June 2011, Springer Science + Business Media

    Dr Seppo Yla-Herttuala

  180. Stabilisation of atherosclerotic plaques

    Article • Thrombosis and Haemostasis, June 2011, Schattauer GmbH

    Dr Seppo Yla-Herttuala

  181. Long-term VEGF-A expression promotes aberrant angiogenesis and fibrosis in skeletal muscle

    Article • Gene Therapy, June 2011, Nature

    Dr Seppo Yla-Herttuala

  182. Upregulated Signaling Pathways in Ruptured Human Saccular Intracranial Aneurysm Wall

    Article • Neurosurgery, June 2011, Oxford University Press (OUP)

    Dr Seppo Yla-Herttuala

  183. 404 EVALUATION OF A DIABETIC RABBIT MODEL FOR IN-STENT RESTENOSIS

    Article • Atherosclerosis Supplements, June 2011, Elsevier

    Dr Seppo Yla-Herttuala

  184. 377 EFFECTS OF TACROLIMUS-ELUTING STENTS IN A DIABETIC RABBIT MODEL OF IN-STENT RESTENOSIS

    Article • Atherosclerosis Supplements, June 2011, Elsevier

    Dr Seppo Yla-Herttuala

  185. Review focus on epigenetics and the histone code in vascular biology

    Article • Cardiovascular Research, May 2011, European Society of Cardiology

    Dr Seppo Yla-Herttuala

  186. Notch restricts lymphatic vessel sprouting induced by vascular endothelial growth factor

    Article • Blood, May 2011, American Society of Hematology

    Dr Seppo Yla-Herttuala

  187. Long-term VEGF-A expression promotes aberrant angiogenesis and fibrosis in skeletal muscle

    Article • Gene Therapy, May 2011, Nature

    Dr Seppo Yla-Herttuala

  188. Abstract LB-422: Photodynamic ablation of lymphatic vessels and intralymphatic cancer cells prevents metastasis

    Article • Cancer Research, April 2011, American Association for Cancer Research (AACR)

    Dr Seppo Yla-Herttuala

  189. Epigenetic regulation of key vascular genes and growth factors

    Article • Cardiovascular Research, April 2011, European Society of Cardiology

    PhD Mikko P Turunen, Dr Seppo Yla-Herttuala

  190. Progress and prospects: hurdles to cardiovascular gene therapy clinical trials

    Article • Gene Therapy, April 2011, Nature

    Dr Seppo Yla-Herttuala

  191. Gamma-Secretase Inhibitor Treatment Promotes VEGF-A-Driven Blood Vessel Growth and Vascular Leakage but Disrupts Neovascular Perfusion

    Article • PLoS ONE, April 2011, PLOS

    Dr Seppo Yla-Herttuala

  192. Vascular Endothelial Growth Factor (VEGF)-D Stimulates VEGF-A, Stanniocalcin-1, and Neuropilin-2 and Has Potent Angiogenic Effects

    Article • Arteriosclerosis Thrombosis and Vascular Biology, April 2011, Wolters Kluwer Health

    Dr Seppo Yla-Herttuala

  193. Therapeutic delivery using gene-delivery methods

    Article • Therapeutic Delivery, April 2011, Future Science

    Dr Seppo Yla-Herttuala

  194. 341 VEGF-C/VEGFR-3 Signaling Regulates Inflammatory Response in Development of Obliterative Airway Disease

    Article • The Journal of Heart and Lung Transplantation, April 2011, Elsevier

    Dr Seppo Yla-Herttuala

  195. Detection of Hypoxia by [18F]EF5 in Atherosclerotic Plaques in Mice

    Article • Arteriosclerosis Thrombosis and Vascular Biology, March 2011, Wolters Kluwer Health

    Dr Seppo Yla-Herttuala

  196. Electrophilic Nitro-fatty Acids Activate NRF2 by a KEAP1 Cysteine 151-independent Mechanism

    Article • Journal of Biological Chemistry, February 2011, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Seppo Yla-Herttuala

  197. Photodynamic Ablation of Lymphatic Vessels and Intralymphatic Cancer Cells Prevents Metastasis

    Article • Science Translational Medicine, February 2011, American Association for the Advancement of Science

    Dr Seppo Yla-Herttuala

  198. Gene Therapy Moves Forward in 2010

    Article • Molecular Therapy, February 2011, Elsevier

    Dr Seppo Yla-Herttuala

  199. Vascular endothelial growth factors in retinal and choroidal neovascular diseases

    Article • Annals of Medicine, February 2011, Informa Healthcare

    Dr Seppo Yla-Herttuala

  200. Growth Factor Therapy and Autologous Lymph Node Transfer in Lymphedema

    Article • Circulation, January 2011, Wolters Kluwer Health

    Dr Seppo Yla-Herttuala

  201. Production and purification of lentiviral vectors generated in 293T suspension cells with baculoviral vectors

    Article • Gene Therapy, January 2011, Nature

    Dr Seppo Yla-Herttuala

  202. Crystal structure of vascular endothelial growth factor D

    Article • January 2011, Protein Data Bank, Rutgers University

    Dr Seppo Yla-Herttuala

  203. Epigenetherapy, a new concept

    Article • BioMolecular Concepts, January 2011, De Gruyter

    PhD Mikko P Turunen, Dr Seppo Yla-Herttuala

  204. Glioblastoma Multiforme: Use of Adenoviral Vectors

    Article • January 2011, Springer Science + Business Media

    Dr Seppo Yla-Herttuala

  205. Baculoviruses Mediate Efficient Gene Expression in a Wide Range of Vertebrate Cells

    Article • January 2011, Springer Science + Business Media

    Dr Seppo Yla-Herttuala

  206. TAFFEL: Independent Enrichment Analysis of gene sets

    Article • BMC Bioinformatics, January 2011, Springer Science + Business Media

    Dr Seppo Yla-Herttuala

  207. Left ventricular dysfunction with reduced functional cardiac reserve in diabetic and non-diabetic LDL-receptor deficient apolipoprotein B100-only mice

    Article • Cardiovascular Diabetology, January 2011, Springer Science + Business Media

    Dr Seppo Yla-Herttuala

  208. Uptake of 68gallium in atherosclerotic plaques in LDLR-/-ApoB100/100 mice

    Article • EJNMMI Research, January 2011, Springer Science + Business Media

    Dr Seppo Yla-Herttuala

  209. Structural determinants of vascular endothelial growth factor-D receptor binding and specificity

    Article • Blood, December 2010, American Society of Hematology

    Dr Seppo Yla-Herttuala, Dr Michael Jeltsch

  210. Capillary enlargement, not sprouting angiogenesis, determines beneficial therapeutic effects and side effects of angiogenic gene therapy

    Article • European Heart Journal, December 2010, European Society of Cardiology

    Dr Seppo Yla-Herttuala

  211. Lymphatic vasculature is increased in heart valves, ischaemic and inflamed hearts and in cholesterol-rich and calcified atherosclerotic lesions

    Article • European Journal of Clinical Investigation, December 2010, Wiley

    Dr Seppo Yla-Herttuala

  212. Relevance of an Academic GMP Pan-European Vector Infra-Structure (PEVI)

    Article • Current Gene Therapy, December 2010, Bentham Science Publishers

    Dr Seppo Yla-Herttuala

  213. Epigenetics and atherosclerosis

    Article • Clínica e Investigación en Arteriosclerosis, December 2010, Elsevier

    Dr Seppo Yla-Herttuala

  214. Primary effect of 1α,25(OH)2D3 on IL-10 expression in monocytes is short-term down-regulation

    Article • Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, November 2010, Elsevier

    PhD Mikko P Turunen, Dr Seppo Yla-Herttuala

  215. In vivo SPECT/CT imaging of human orthotopic ovarian carcinoma xenografts with 111In-labeled monoclonal antibodies

    Article • Nuclear Medicine and Biology, November 2010, Elsevier

    Dr Seppo Yla-Herttuala

  216. Sulforaphane inhibits endothelial lipase expression through NF-κB in endothelial cells

    Article • Atherosclerosis, November 2010, Elsevier

    Dr Seppo Yla-Herttuala

  217. Vascular Endothelial Growth Factor-B Acts as a Coronary Growth Factor in Transgenic Rats Without Inducing Angiogenesis, Vascular Leak, or Inflammation

    Article • Circulation, October 2010, Wolters Kluwer Health

    Dr Seppo Yla-Herttuala, Dr Michael Jeltsch

  218. Cotargeting of VEGFR-1 and -3 and angiopoietin receptor Tie2 reduces the growth of solid human ovarian cancer in mice

    Article • Cancer Gene Therapy, September 2010, Nature

    Dr Seppo Yla-Herttuala

  219. Vascular endothelial growth factor-B gene transfer prevents angiotensin II-induced diastolic dysfunction via proliferation and capillary dilatation in rats

    Article • Cardiovascular Research, August 2010, European Society of Cardiology

    Dr Seppo Yla-Herttuala

  220. Silencing of either SR-A or CD36 reduces atherosclerosis in hyperlipidaemic mice and reveals reciprocal upregulation of these receptors

    Article • Cardiovascular Research, July 2010, European Society of Cardiology

    PhD Mikko P Turunen, Dr Seppo Yla-Herttuala

  221. Enhanced angiogenesis and reduced infarct size by vascular endothelial growth factor D is not translated to behavioral outcome in a rat model of ischemic stroke

    Article • Journal of Experimental Stroke and Translational Medicine, July 2010, Association of Experimental Stroke and Translational Medicine

    Dr Seppo Yla-Herttuala

  222. In Vivo Application and Tracking of Baculovirus

    Article • Current Gene Therapy, June 2010, Bentham Science Publishers

    Dr Seppo Yla-Herttuala

  223. Cytochrome P450 2A5 Constitutive Expression and Induction by Heavy Metals Is Dependent on Redox-Sensitive Transcription Factor Nrf2 in Liver

    Article • Chemical Research in Toxicology, May 2010, American Chemical Society (ACS)

    Dr Seppo Yla-Herttuala

  224. Screening of Complement Inhibitors: Shielded Baculoviruses Increase the Safety and Efficacy of Gene Delivery

    Article • Molecular Therapy, May 2010, Elsevier

    Dr Seppo Yla-Herttuala

  225. VEGF-D△N△Cmediated angiogenesis in skeletal muscles of diabetic WHHL rabbits

    Article • European Journal of Clinical Investigation, May 2010, Wiley

    Dr Seppo Yla-Herttuala

  226. Production of HIV-1 Integrase Fusion Protein-Carrying Lentiviral Vectors for Gene Therapy and Protein Transduction

    Article • Human Gene Therapy, May 2010, Mary Ann Liebert Inc

    Dr Seppo Yla-Herttuala

  227. Uptake of 11C-Choline in Mouse Atherosclerotic Plaques

    Article • Journal of Nuclear Medicine, April 2010, Society of Nuclear Medicine

    Dr Seppo Yla-Herttuala

  228. New aspects in vascular gene therapy

    Article • Current Opinion in Pharmacology, April 2010, Elsevier

    Dr Seppo Yla-Herttuala

  229. Future Prospects and Challenges of Antiangiogenic Cancer Gene Therapy

    Article • Human Gene Therapy, April 2010, Mary Ann Liebert Inc

    Dr Seppo Yla-Herttuala

  230. Avidin-biotin technology in targeted therapy

    Article • Expert Opinion on Drug Delivery, March 2010, Informa Healthcare

    Dr Seppo Yla-Herttuala

  231. Targeting Lymphatic Vessel Activation and CCL21 Production by Vascular Endothelial Growth Factor Receptor-3 Inhibition Has Novel Immunomodulatory and Antiarteriosclerotic Effects in Cardiac Allografts

    Article • Circulation, March 2010, Wolters Kluwer Health

    Dr Seppo Yla-Herttuala

  232. Vascular endothelial growth factor B controls endothelial fatty acid uptake

    Article • Nature, March 2010, Nature

    Dr Seppo Yla-Herttuala

  233. VEGF receptor 2/-3 heterodimers detected in situ by proximity ligation on angiogenic sprouts

    Article • The EMBO Journal, March 2010, Wiley

    Dr Seppo Yla-Herttuala

  234. Morphological characterization of baculovirus Autographa californica multiple nucleopolyhedrovirus

    Article • Virus Research, March 2010, Elsevier

    Dr Seppo Yla-Herttuala

  235. Stimulation of functional vessel growth by gene therapy

    Article • Integrative Biology, January 2010, Oxford University Press (OUP)

    Dr Seppo Yla-Herttuala

  236. Combined vascular endothelial growth factor-A and fibroblast growth factor 4 gene transfer improves wound healing in diabetic mice

    Article • Genetic Vaccines and Therapy, January 2010, Springer Science + Business Media

    Dr Seppo Yla-Herttuala

  237. Antioxidant Response Element-Regulated Vectors for Cancer Gene Therapy

    Article • Free Radical Biology and Medicine, January 2010, Elsevier

    Dr Seppo Yla-Herttuala

  238. Culture medium induced vimentin reorganization associates with enhanced baculovirus-mediated gene delivery

    Article • Journal of Biotechnology, January 2010, Elsevier

    Dr Seppo Yla-Herttuala

  239. The effects of VEGF-R1 and VEGF-R2 ligands on angiogenic responses and left ventricular function in mice

    Article • Cardiovascular Research, December 2009, European Society of Cardiology

    Dr Seppo Yla-Herttuala

  240. Gene therapy with vascular endothelial growth factors

    Article • Biochemical Society Transactions, December 2009, Portland Press Ltd.

    Dr Seppo Yla-Herttuala

  241. Intravitreal Adenoviral 15-Lipoxygenase-1 Gene Transfer Prevents Vascular Endothelial Growth Factor A-Induced Neovascularization in Rabbit Eyes

    Article • Human Gene Therapy, December 2009, Mary Ann Liebert Inc

    Dr Seppo Yla-Herttuala

  242. Antegrade flow and peripheral resistance determine the level of endogenous arteriogenesis in patients with superficial femoral artery occlusion

    Article • European Journal of Clinical Investigation, October 2009, Wiley

    Dr Seppo Yla-Herttuala

  243. Nrf2-dependent and -independent Responses to Nitro-fatty Acids in Human Endothelial Cells: IDENTIFICATION OF HEAT SHOCK RESPONSE AS THE MAJOR PATHWAY ACTIVATED BY NITRO-OLEIC ACID

    Article • Journal of Biological Chemistry, October 2009, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Seppo Yla-Herttuala

  244. Adenovirus Mediated Herpes Simplex Virus-Thymidine Kinase/Ganciclovir Gene Therapy for Resectable Malignant Glioma

    Article • Current Gene Therapy, October 2009, Bentham Science Publishers

    Dr Seppo Yla-Herttuala

  245. Prognostic value of the apoptotic index analysed jointly with selected cell cycle regulators and proliferation markers in non-small cell lung cancer

    Article • Lung Cancer, October 2009, Elsevier

    Dr Seppo Yla-Herttuala

  246. Intrahippocampal injection of a lentiviral vector expressing Nrf2 improves spatial learning in a mouse model of Alzheimer's disease

    Article • Proceedings of the National Academy of Sciences, September 2009, Proceedings of the National Academy of Sciences

    Dr Seppo Yla-Herttuala

  247. Epigenetics and atherosclerosis

    Article • Biochimica et Biophysica Acta (BBA) - General Subjects, September 2009, Elsevier

    PhD Mikko P Turunen, Dr Seppo Yla-Herttuala

  248. Expression of urokinase-type plasminogen activator receptor is increased during epileptogenesis in the rat hippocampus

    Article • Neuroscience, September 2009, Elsevier

    PhD Mikko P Turunen, Dr Seppo Yla-Herttuala

  249. Efficient Regulation of VEGF Expression by Promoter-Targeted Lentiviral shRNAs Based on Epigenetic Mechanism: A Novel Example of Epigenetherapy

    Article • Circulation Research, August 2009, Wolters Kluwer Health

    PhD Mikko P Turunen, Dr Seppo Yla-Herttuala

  250. Homology modeling of VEGF-D as a basis for structural and functional analysis

    Article • Acta Crystallographica Section A Foundations of Crystallography, August 2009, International Union of Crystallography

    Dr Seppo Yla-Herttuala

  251. Avidin Fusion Protein-Expressing Lentiviral Vector for Targeted Drug Delivery

    Article • Human Gene Therapy, August 2009, Mary Ann Liebert Inc

    Dr Seppo Yla-Herttuala

  252. 68Ga-DOTA-RGD peptide: biodistribution and binding into atherosclerotic plaques in mice

    Article • European Journal of Nuclear Medicine and Molecular Imaging, July 2009, Springer Science + Business Media

    Dr Seppo Yla-Herttuala

  253. HIF-1 Induction Attenuates Nrf2-Dependent IL-8 Expression in Human Endothelial Cells

    Article • Antioxidants & Redox Signaling, July 2009, Mary Ann Liebert Inc

    Dr Seppo Yla-Herttuala

  254. Development of Safe and Efficient Viral Vectors for Clinical Gene Therapy

    Article • Journal of Nanoneuroscience, June 2009, American Scientific Publishers

    Dr Seppo Yla-Herttuala

  255. A preclinical assessment of the safety and biodistribution of an adenoviral vector containing the herpes simplex virus thymidine kinase gene (Cerepro®) after intracerebral administration

    Article • The Journal of Gene Medicine, June 2009, Wiley

    Dr Seppo Yla-Herttuala

  256. (Strept)avidin-displaying lentiviruses as versatile tools for targeting and dual imaging of gene delivery

    Article • Gene Therapy, May 2009, Nature

    Dr Seppo Yla-Herttuala

  257. Activated Forms of VEGF-C and VEGF-D Provide Improved Vascular Function in Skeletal Muscle

    Article • Circulation Research, May 2009, Wolters Kluwer Health

    Dr Seppo Yla-Herttuala, Dr Michael Jeltsch

  258. Evaluation of  v 3 Integrin-Targeted Positron Emission Tomography Tracer 18F-Galacto-RGD for Imaging of Vascular Inflammation in Atherosclerotic Mice

    Article • Circulation Cardiovascular Imaging, May 2009, Wolters Kluwer Health

    Dr Seppo Yla-Herttuala

  259. FOXC2 controls formation and maturation of lymphatic collecting vessels through cooperation with NFATc1

    Article • The Journal of Experimental Medicine, May 2009, Rockefeller University Press

    Dr Seppo Yla-Herttuala

  260. Baculovirus is an efficient vector for the transduction of the eye: comparison of baculovirus- and adenovirus-mediated intravitreal vascular endothelial growth factor D gene transfer in the rabbit eye

    Article • The Journal of Gene Medicine, May 2009, Wiley

    Dr Seppo Yla-Herttuala

  261. FOXC2 controls formation and maturation of lymphatic collecting vessels through cooperation with NFATc1

    Article • The Journal of Cell Biology, April 2009, Rockefeller University Press

    Dr Seppo Yla-Herttuala

  262. Development of atherosclerotic plaques

    Article • Acta Medica Scandinavica, April 2009, Wiley

    Dr Seppo Yla-Herttuala

  263. Novel Vascular Endothelial Growth Factor D Variants with Increased Biological Activity

    Article • Journal of Biological Chemistry, April 2009, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Seppo Yla-Herttuala

  264. VEGF-B is dispensable for blood vessel growth but critical for their survival, and VEGF-B targeting inhibits pathological angiogenesis

    Article • Proceedings of the National Academy of Sciences, April 2009, Proceedings of the National Academy of Sciences

    Dr Seppo Yla-Herttuala

  265. Clathrin-Independent Entry of Baculovirus Triggers Uptake of E. coli in Non-Phagocytic Human Cells

    Article • PLoS ONE, April 2009, PLOS

    Dr Seppo Yla-Herttuala

  266. PDGF-C and -D and their receptors PDGFR-α and PDGFR-β in atherosclerotic human arteries

    Article • European Journal of Clinical Investigation, April 2009, Wiley

    Dr Seppo Yla-Herttuala

  267. Molecular genetics of atherosclerosis

    Article • Human Genetics, March 2009, Springer Science + Business Media

    Dr Seppo Yla-Herttuala

  268. Differences in retinal neovascular tissue and vitreous humour in patients with type 1 and type 2 diabetes

    Article • British Journal of Ophthalmology, March 2009, BMJ

    Dr Seppo Yla-Herttuala

  269. Preparation of Recombinant Baculoviruses with the BVboost System

    Article • Cold Spring Harbor Protocols, March 2009, Cold Spring Harbor Laboratory Press

    Dr Seppo Yla-Herttuala

  270. Transduction of Vertebrate Cells with Recombinant Baculovirus

    Article • Cold Spring Harbor Protocols, March 2009, Cold Spring Harbor Laboratory Press

    Dr Seppo Yla-Herttuala

  271. Eight-year safety follow-up of coronary artery disease patients after local intracoronary VEGF gene transfer

    Article • Gene Therapy, February 2009, Nature

    Dr Seppo Yla-Herttuala

  272. Vascular Endothelial Growth Factor-B Induces Myocardium-Specific Angiogenesis and Arteriogenesis via Vascular Endothelial Growth Factor Receptor-1- and Neuropilin Receptor-1-Dependent Mechanisms

    Article • Circulation, February 2009, Wolters Kluwer Health

    Dr Seppo Yla-Herttuala

  273. Antiangiogenic Gene Therapy With Soluble VEGFR-1, -2, and -3 Reduces the Growth of Solid Human Ovarian Carcinoma in Mice

    Article • Molecular Therapy, February 2009, Elsevier

    Dr Seppo Yla-Herttuala

  274. VEGF-A Links Angiogenesis and Inflammation in Inflammatory Bowel Disease Pathogenesis

    Article • Gastroenterology, February 2009, Elsevier

    Dr Seppo Yla-Herttuala

  275. 454: Targeting Lymphatic Vessel CCL21 Production by VEGFR-3 Inhibition Prevents Cardiac Allograft Rejection and Arteriosclerosis

    Article • The Journal of Heart and Lung Transplantation, February 2009, Elsevier

    Dr Seppo Yla-Herttuala

  276. Challenges in monoclonal antibody-based therapies

    Article • Annals of Medicine, January 2009, Taylor & Francis

    Dr Seppo Yla-Herttuala

  277. A 96-well format for a high-throughput baculovirus generation, fast titering and recombinant protein production in insect and mammalian cells

    Article • BMC Research Notes, January 2009, Springer Science + Business Media

    Dr Seppo Yla-Herttuala

  278. Vascular endothelial growth factor-D transgenic mice show enhanced blood capillary density, improved postischemic muscle regeneration, and increased susceptibility to tumor formation

    Article • Blood, December 2008, American Society of Hematology

    PhD Mikko P Turunen, Dr Seppo Yla-Herttuala

  279. Stabilization of HIF-1α is critical to improve wound healing in diabetic mice

    Article • Proceedings of the National Academy of Sciences, December 2008, Proceedings of the National Academy of Sciences

    Dr Seppo Yla-Herttuala

  280. Vascular Endothelial Growth Factor-A and Platelet-Derived Growth Factor-B Combination Gene Therapy Prolongs Angiogenic Effects via Recruitment of Interstitial Mononuclear Cells and Paracrine Effects Rather Than Improved Pericyte Coverage of Angiogenic ...

    Article • Circulation Research, November 2008, Wolters Kluwer Health

    Dr Seppo Yla-Herttuala

  281. Baculovirus-Mediated Gene Transfer

    Article • October 2008, Taylor & Francis

    Dr Seppo Yla-Herttuala

  282. Nuclear factor erythroid 2-related factor 2 protects against beta amyloid

    Article • Molecular and Cellular Neuroscience, October 2008, Elsevier

    Dr Seppo Yla-Herttuala

  283. Prox1 interacts with Atoh1 and Gfi1, and regulates cellular differentiation in the inner ear sensory epithelia

    Article • Developmental Biology, October 2008, Elsevier

    Dr Seppo Yla-Herttuala

  284. The administration of an adenoviral thymidine kinase suicide gene to the uterine artery of rabbits does not affect fertility: a safety study of pregnant and nonpregnant rabbits and their offspring

    Article • The Journal of Gene Medicine, September 2008, Wiley

    Dr Seppo Yla-Herttuala

  285. Severe coronary artery stenoses and reduced coronary flow velocity reserve in atherosclerotic mouse model

    Article • Atherosclerosis, September 2008, Elsevier

    Dr Seppo Yla-Herttuala

  286. Extended release of adenovirus from silica implants in vitro and in vivo

    Article • Gene Therapy, August 2008, Nature

    Dr Seppo Yla-Herttuala

  287. Reply to Kerbel et al. : EPCs are again claimed to be essential in yet other models despite the irreproducibility of the original experiments introducing them

    Article • Proceedings of the National Academy of Sciences, August 2008, Proceedings of the National Academy of Sciences

    Dr Seppo Yla-Herttuala

  288. Uptake of inflammatory cell marker [11C]PK11195 into mouse atherosclerotic plaques

    Article • European Journal of Nuclear Medicine and Molecular Imaging, August 2008, Springer Science + Business Media

    Dr Seppo Yla-Herttuala

  289. Therapeutic angiogenesis with placental growth factor improves exercise tolerance of ischaemic rabbit hindlimbs

    Article • Cardiovascular Research, July 2008, European Society of Cardiology

    Dr Seppo Yla-Herttuala

  290. Nrf2 Regulates Antioxidant Gene Expression Evoked by Oxidized Phospholipids in Endothelial Cells and Murine Arteries In Vivo

    Article • Circulation Research, July 2008, Wolters Kluwer Health

    Dr Seppo Yla-Herttuala

  291. Overexpression of Vascular Endothelial Growth Factor-B in Mouse Heart Alters Cardiac Lipid Metabolism and Induces Myocardial Hypertrophy

    Article • Circulation Research, July 2008, Wolters Kluwer Health

    Dr Seppo Yla-Herttuala, Dr Michael Jeltsch

  292. Antibody reactivity to an Epstein-Barr virus BERF4-encoded epitope occurring also in Asp-57 region of HLA-DQ8 β chain

    Article • Clinical & Experimental Immunology, June 2008, Wiley

    Dr Seppo Yla-Herttuala

  293. Blocking VEGFR-3 suppresses angiogenic sprouting and vascular network formation

    Article • Nature, June 2008, Nature

    Dr Seppo Yla-Herttuala

  294. The Tyrosine Kinase Inhibitor Cediranib Blocks Ligand-Induced Vascular Endothelial Growth Factor Receptor-3 Activity and Lymphangiogenesis

    Article • Cancer Research, June 2008, American Association for Cancer Research (AACR)

    Dr Seppo Yla-Herttuala, Dr Michael Jeltsch

  295. Hypoxia induces microRNA miR-210 in vitro and in vivo

    Article • FEBS Letters, June 2008, Wiley

    PhD Mikko P Turunen, Dr Seppo Yla-Herttuala

  296. Targeting and Purification of Metabolically Biotinylated Baculovirus

    Article • Human Gene Therapy, June 2008, Mary Ann Liebert Inc

    Dr Seppo Yla-Herttuala

  297. Gene therapy to prevent occlusion of venous bypass grafts

    Article • Expert Review of Cardiovascular Therapy, June 2008, Informa Healthcare

    Dr Seppo Yla-Herttuala

  298. Respiratory infection recurrence and passive smoking in early atherosclerosis in children and adolescents with type 1 diabetes

    Article • European Journal of Clinical Investigation, June 2008, Wiley

    Dr Seppo Yla-Herttuala

  299. Generation of lentivirus vectors using recombinant baculoviruses

    Article • Gene Therapy, May 2008, Nature

    Dr Seppo Yla-Herttuala

  300. KLF2 Primes the Antioxidant Transcription Factor Nrf2 for Activation in Endothelial Cells

    Article • Arteriosclerosis Thrombosis and Vascular Biology, May 2008, Wolters Kluwer Health

    Dr Seppo Yla-Herttuala

  301. Bone marrow-derived circulating endothelial precursors do not contribute to vascular endothelium and are not needed for tumor growth

    Article • Proceedings of the National Academy of Sciences, May 2008, Proceedings of the National Academy of Sciences

    Dr Seppo Yla-Herttuala

  302. Experimental hyperlipidaemia does not prevent preconditioning and it reduces ischemia-induced apoptosis

    Article • International Journal of Cardiology, May 2008, Elsevier

    Dr Seppo Yla-Herttuala

  303. Oxidative stress-inducible lentiviral vectors for gene therapy

    Article • Gene Therapy, May 2008, Nature

    Dr Seppo Yla-Herttuala

  304. THE EFFECT OF VEGF-A GENE TRANSFER ON ATHEROSCLEROSIS, LIPOPROTEIN PROFILES AND LPL ACTIVITY

    Article • Atherosclerosis Supplements, May 2008, Elsevier

    Dr Seppo Yla-Herttuala

  305. Antioxidant Gene Therapy for Cardiovascular Disease: Current Status and Future Perspectives

    Article • Circulation, March 2008, Wolters Kluwer Health

    Dr Seppo Yla-Herttuala

  306. Baculovirus-mediated immediate-early gene expression and nuclear reorganization in human cells

    Article • Cellular Microbiology, March 2008, Wiley

    Dr Seppo Yla-Herttuala

  307. VEGF-C induced angiogenesis preferentially occurs at a distance from lymphangiogenesis

    Article • Cardiovascular Research, February 2008, European Society of Cardiology

    Dr Seppo Yla-Herttuala

  308. 29: Role of Vascular Endothelial Growth Factor-C in Experimental Obliterative Airway Disease

    Article • The Journal of Heart and Lung Transplantation, February 2008, Elsevier

    Dr Seppo Yla-Herttuala

  309. 417: Constitutively Expressed Hypoxia-Inducible Factor-1α Prevents the Development of Cardiac Allograft Vasculopathy in the Rat

    Article • The Journal of Heart and Lung Transplantation, February 2008, Elsevier

    Dr Seppo Yla-Herttuala

  310. 15-Lipoxygenase-1 Prevents Vascular Endothelial Growth Factor A- and Placental Growth Factor-Induced Angiogenic Effects in Rabbit Skeletal Muscles via Reduction in Growth Factor mRNA Levels, NO Bioactivity, and Downregulation of VEGF Receptor 2 Expression

    Article • Circulation Research, February 2008, Wolters Kluwer Health

    Dr Seppo Yla-Herttuala

  311. Simvastatin has an anti-inflammatory effect on macrophages via upregulation of an atheroprotective transcription factor, Kruppel-like factor 2

    Article • Cardiovascular Research, January 2008, European Society of Cardiology

    PhD Mikko P Turunen, Dr Seppo Yla-Herttuala

  312. Endothelial 15-Lipoxygenase-1 Overexpression Increases Acetylcholine-Induced Hypotension and Vasorelaxation in Rabbits

    Article • Hypertension, January 2008, Wolters Kluwer Health

    Dr Seppo Yla-Herttuala

  313. Improving Safety of Gene Therapy

    Article • Current Drug Safety, January 2008, Bentham Science Publishers

    Dr Seppo Yla-Herttuala

  314. Gene Therapy: The First Approved Gene-Based Medicines, Molecular Mechanisms and Clinical Indications

    Article • Current Molecular Pharmacology, January 2008, Bentham Science Publishers

    Dr Seppo Yla-Herttuala

  315. High-Resolution Ultrasound Perfusion Imaging of Therapeutic Angiogenesis

    Article • JACC Cardiovascular Imaging, January 2008, Elsevier

    Dr Seppo Yla-Herttuala

  316. 1H MR spectroscopic imaging of phospholipase-mediated membrane lipid release in apoptotic rat glioma in vivo

    Article • Magnetic Resonance in Medicine, January 2008, Wiley

    Dr Seppo Yla-Herttuala

  317. Gene Therapy: The First Approved Gene-Based Medicines, Molecular Mechanisms and Clinical Indications

    Article • Current Molecular Pharmacology, January 2008, Bentham Science Publishers

    Dr Seppo Yla-Herttuala

  318. Water spin dynamics during apoptotic cell death in glioma gene therapy probed byT1ρ andT2ρ

    Article • Magnetic Resonance in Medicine, January 2008, Wiley

    Dr Seppo Yla-Herttuala

  319. On the relationship of LDL and VEGFR1: not just a family affair

    Article • EMBO Reports, December 2007, Wiley

    Dr Seppo Yla-Herttuala

  320. Therapeutic differentiation and maturation of lymphatic vessels after lymph node dissection and transplantation

    Article • Nature Reports Stem Cells, December 2007, Nature

    Dr Seppo Yla-Herttuala

  321. Umbilical Cord Blood–derived Progenitor Cells Enhance Muscle Regeneration in Mouse Hindlimb Ischemia Model

    Article • Molecular Therapy, December 2007, Elsevier

    Dr Seppo Yla-Herttuala

  322. Extracellular Superoxide Dismutase Accelerates Endothelial Recovery and Inhibits In-Stent Restenosis in Stented Atherosclerotic Watanabe Heritable Hyperlipidemic Rabbit Aorta

    Article • Journal of the American College of Cardiology, December 2007, Elsevier

    Dr Seppo Yla-Herttuala

  323. Corrigendum to “Non-invasive Imaging in Gene Therapy”

    Article • Molecular Therapy, November 2007, Elsevier

    Dr Seppo Yla-Herttuala

  324. Progress and Prospects: Gene Therapy Clinical Trials (Part 1)

    Article • Gene Therapy, October 2007, Nature

    Dr Seppo Yla-Herttuala

  325. Increased Atherosclerotic Lesion Calcification in a Novel Mouse Model Combining Insulin Resistance, Hyperglycemia, and Hypercholesterolemia

    Article • Circulation Research, September 2007, Wolters Kluwer Health

    Dr Seppo Yla-Herttuala

  326. Non-invasive Imaging in Gene Therapy

    Article • Molecular Therapy, September 2007, Elsevier

    Dr Seppo Yla-Herttuala

  327. Rhizavidin fromRhizobium etli: the first natural dimer in the avidin protein family

    Article • Biochemical Journal, August 2007, Portland Press Ltd.

    Dr Seppo Yla-Herttuala

  328. Post-transcriptional regulatory element boosts baculovirus-mediated gene expression in vertebrate cells

    Article • Journal of Biotechnology, August 2007, Elsevier

    Dr Seppo Yla-Herttuala

  329. Current Status of Cardiovascular Gene Therapy

    Article • Molecular Therapy, July 2007, Elsevier

    Dr Seppo Yla-Herttuala

  330. Low Spin-Lock Field T1 Relaxation in the Rotating Frame as a Sensitive MR Imaging Marker for Gene Therapy Treatment Response in Rat Glioma1

    Article • Radiology, June 2007, Radiological Society of North America (RSNA)

    Professor Risto A Kauppinen, Dr Seppo Yla-Herttuala

  331. High resolution ultrasound perfusion imaging of therapeutic angiogenesis

    Article • International Journal of Cardiology, June 2007, Elsevier

    Dr Seppo Yla-Herttuala

  332. Therapeutic angiogenesis induced by gene transfer of placental growth factor improves exercise tolerance of ischemic rabbit hindlimbs

    Article • International Journal of Cardiology, June 2007, Elsevier

    Dr Seppo Yla-Herttuala

  333. PO9-234 NRF2 DOWN-REGULATES THIOREDOXIN INTERACTING PROTEIN (TXNIP) EXPRESSION

    Article • Atherosclerosis Supplements, June 2007, Elsevier

    Dr Seppo Yla-Herttuala

  334. LB-PO-854 LONG-TERM SAFETY STUDY OF LIVER-DIRECTED IN VIVO GENE TRANSFER WITH MOLONEY MURINE RETROVIRUSES AND LENTIVIRUSES IN WATANABE HERITABLE HYPERLIPIDEMIC RABBITS

    Article • Atherosclerosis Supplements, June 2007, Elsevier

    Dr Seppo Yla-Herttuala

  335. PO6-160 GENE TRANSFERS OF VEGF-GENE FAMILY HAVE NO EFFECT ON ATHEROSCLEROSIS IN LDLR/APOB48-DEFICIENT MICE

    Article • Atherosclerosis Supplements, June 2007, Elsevier

    Dr Seppo Yla-Herttuala

  336. PO8-189 SUPEROXIDE DISMUTASE MIMETIC AEOL 10113 REDUCES OXIDATIVE STRESS, PROMOTES RE-ENDOTHELIZATION AND INHIBITS IN-STENT RESTENOSIS IN WHHL-RABBIT ARTERIES

    Article • Atherosclerosis Supplements, June 2007, Elsevier

    Dr Seppo Yla-Herttuala

  337. PO9-244 UPTAKE OF 11C-PK11195, A MARKER OF INFLAMMATORY CELLS, INTO ATHEROSCLEROTIC PLAQUES IN MICE

    Article • Atherosclerosis Supplements, June 2007, Elsevier

    Dr Seppo Yla-Herttuala

  338. PO11-294 A NEW MOUSE MODEL OF DIABETIC ATHEROSCLEROSIS REVEALS INCREASED LESION COMPLEXITY AND CALCIFICATION WITHOUT WORSENING OF HYPERCHOLESTEROLEMIA

    Article • Atherosclerosis Supplements, June 2007, Elsevier

    Dr Seppo Yla-Herttuala

  339. Distinct vascular endothelial growth factor signals for lymphatic vessel enlargement and sprouting

    Article • The Journal of Experimental Medicine, May 2007, Rockefeller University Press

    Dr Seppo Yla-Herttuala

  340. Enhanced Capillary Formation Stimulated by a Chimeric Vascular Endothelial Growth Factor/Vascular Endothelial Growth Factor-C Silk Domain Fusion Protein

    Article • Circulation Research, May 2007, Wolters Kluwer Health

    Dr Seppo Yla-Herttuala, Dr Michael Jeltsch

  341. Distinct Architecture of Lymphatic Vessels Induced by Chimeric Vascular Endothelial Growth Factor-C/Vascular Endothelial Growth Factor Heparin-Binding Domain Fusion Proteins

    Article • Circulation Research, May 2007, Wolters Kluwer Health

    Dr Seppo Yla-Herttuala, Dr Michael Jeltsch

  342. Enhanced Polyamine Catabolism Alters Homeostatic Control of White Adipose Tissue Mass, Energy Expenditure, and Glucose Metabolism

    Article • Molecular and Cellular Biology, May 2007, ASM Journals

    Dr Seppo Yla-Herttuala

  343. SPECT/CT imaging of baculovirus biodistribution in rat

    Article • Gene Therapy, April 2007, Nature

    Dr Seppo Yla-Herttuala

  344. Nrf2 Gene Transfer Induces Antioxidant Enzymes and Suppresses Smooth Muscle Cell Growth In Vitro and Reduces Oxidative Stress in Rabbit Aorta In Vivo

    Article • Arteriosclerosis Thrombosis and Vascular Biology, April 2007, Wolters Kluwer Health

    Dr Seppo Yla-Herttuala

  345. Vascular Endothelial Growth Factors

    Article • Journal of the American College of Cardiology, March 2007, Elsevier

    Dr Seppo Yla-Herttuala

  346. Adenovirus-Mediated Gene Transfer of Human Vascular Endothelial Growth Factor-D Induces Transient Angiogenic Effects in Mouse Hind Limb Muscle

    Article • Human Gene Therapy, March 2007, Mary Ann Liebert Inc

    Dr Seppo Yla-Herttuala

  347. Oxysterol Binding Protein Induces Upregulation of SREBP-1c and Enhances Hepatic Lipogenesis

    Article • Arteriosclerosis Thrombosis and Vascular Biology, March 2007, Wolters Kluwer Health

    Dr Seppo Yla-Herttuala

  348. 426: Vascular endothelial growth factor-C enhances experimental obliterative bronchiolitis by inducing lymphangiogenesis

    Article • The Journal of Heart and Lung Transplantation, February 2007, Elsevier

    Dr Seppo Yla-Herttuala

  349. Characterizing atherosclerotic lesions by in-plane ultrasonic TOF measurements

    Article • January 2007, Vienna University of Technology, Institute of General Physics

    Dr Seppo Yla-Herttuala

  350. Transduction patterns and efficiencies in rabbit uterine tissues after intraluminal uterine adenovirus administration vary with the reproductive cycle

    Article • Acta Obstetricia Et Gynecologica Scandinavica, January 2007, Wiley

    Dr Seppo Yla-Herttuala

  351. Residual adverse changes in arterial endothelial function and LDL oxidation after a mild systemic inflammation induced by influenza vaccination

    Article • Annals of Medicine, January 2007, Taylor & Francis

    Dr Seppo Yla-Herttuala

  352. Type I interferon response against viral and non-viral gene transfer in human tumor and primary cell lines

    Article • The Journal of Gene Medicine, January 2007, Wiley

    Dr Seppo Yla-Herttuala

  353. Endostatin inhibits endochondral ossification

    Article • The Journal of Gene Medicine, January 2007, Wiley

    Dr Seppo Yla-Herttuala

  354. Vascular endothelial growth factor-A induces plaque expansion in ApoE knock-out mice by promoting de novo leukocyte recruitment

    Article • Blood, January 2007, American Society of Hematology

    Dr Seppo Yla-Herttuala

  355. Short and Long-Term Effects of hVEGF-A165 in Cre-Activated Transgenic Mice

    Article • PLoS ONE, December 2006, PLOS

    Dr Seppo Yla-Herttuala

  356. Adventitial VEGF165 gene transfer prevents lumen loss through induction of positive arterial remodeling after PTCA in porcine coronary arteries

    Article • Atherosclerosis, November 2006, Elsevier

    Dr Seppo Yla-Herttuala

  357. Adenoviral expression of 15-lipoxygenase-1 in rabbit aortic endothelium: role in arachidonic acid-induced relaxation

    Article • AJP Heart and Circulatory Physiology, October 2006, American Physiological Society

    Dr Seppo Yla-Herttuala

  358. VEGF-A, VEGF-D, VEGF receptor-1, VEGF receptor-2, NF- B, and RAGE in atherosclerotic lesions of diabetic Watanabe heritable hyperlipidemic rabbits

    Article • The FASEB Journal, October 2006, Federation of American Societies For Experimental Biology (FASEB)

    Dr Seppo Yla-Herttuala

  359. A highly reproducible xenograft model for human ovarian carcinoma and application of MRI and ultrasound in longitudinal follow-up

    Article • Gynecologic Oncology, October 2006, Elsevier

    Dr Seppo Yla-Herttuala

  360. Atherosclerosis: Gene Therapy

    Article • September 2006, Wiley

    Dr Seppo Yla-Herttuala

  361. Structural pathways for permeability in the porcine and rabbit heart after intramyocardial adenoviral gene transfer of VEGF

    Article • Vascular Pharmacology, September 2006, Elsevier

    Dr Seppo Yla-Herttuala

  362. Vascular Endothelial Growth Factor-C Accelerates Diabetic Wound Healing

    Article • American Journal Of Pathology, September 2006, Elsevier

    Dr Seppo Yla-Herttuala

  363. Safety Profile of Plasmid/Liposomes and Virus Vectors in Clinical Gene Therapy

    Article • Current Drug Safety, August 2006, Bentham Science Publishers

    Dr Seppo Yla-Herttuala

  364. Lymphangiogenic Growth Factor Responsiveness Is Modulated by Postnatal Lymphatic Vessel Maturation

    Article • American Journal Of Pathology, August 2006, Elsevier

    Dr Seppo Yla-Herttuala

  365. Overexpression of VEGF-A induces neovascularization and increased vascular leakage in rabbit eye after intravitreal adenoviral gene transfer

    Article • Acta Physiologica, August 2006, Wiley

    Dr Seppo Yla-Herttuala

  366. Magnetic resonance imaging of viral particle biodistribution in vivo

    Article • Gene Therapy, July 2006, Nature

    Dr Seppo Yla-Herttuala

  367. Non-specific binding of [18F]FDG to calcifications in atherosclerotic plaques: experimental study of mouse and human arteries

    Article • European Journal of Nuclear Medicine and Molecular Imaging, July 2006, Springer Science + Business Media

    Dr Seppo Yla-Herttuala

  368. Adenovirus-Mediated HSV-tk Gene Therapy for Malignant Glioma

    Article • May 2006, Informa Healthcare

    Dr Seppo Yla-Herttuala

  369. Biology of vascular endothelial growth factors

    Article • FEBS Letters, April 2006, Wiley

    Dr Seppo Yla-Herttuala

  370. Extracellular Superoxide Dismutase with Vaccinia Virus Anti-inflammatory Protein 35K or Tissue Inhibitor of Metalloproteinase-1: Combination Gene Therapy in the Treatment of Vein Graft Stenosis in Rabbits

    Article • Human Gene Therapy, April 2006, Mary Ann Liebert Inc

    Dr Seppo Yla-Herttuala

  371. Extracellular Superoxide Dismutase with Vaccinia Virus Anti-inflammatory Protein 35K or Tissue Inhibitor of Metalloproteinase-1: Combination Gene Therapy in the Treatment of Vein Graft Stenosis in Rabbits

    Article • Human Gene Therapy, March 2006, Mary Ann Liebert Inc

    Dr Seppo Yla-Herttuala

  372. Vascular Endothelial Growth Factor C–induced Collateral Formation in a Model of Myocardial Ischemia

    Article • The Journal of Heart and Lung Transplantation, February 2006, Elsevier

    Dr Seppo Yla-Herttuala

  373. New Technologies in Cardiovascular Research: Gene Therapy

    Article • January 2006, Springer Science + Business Media

    PhD Mikko P Turunen, Dr Seppo Yla-Herttuala

  374. Stable RNA interference: comparison of U6 and H1 promoters in endothelial cells and in mouse brain

    Article • The Journal of Gene Medicine, January 2006, Wiley

    PhD Mikko P Turunen, Dr Seppo Yla-Herttuala

  375. Targeted magnetic resonance imaging of Scavidin-receptor in human umbilical vein endothelial cells in vitro

    Article • Magnetic Resonance in Medicine, January 2006, Wiley

    Dr Seppo Yla-Herttuala

  376. Gene Technology Based Therapies in the Brain

    Article • January 2006, Springer Science + Business Media

    Dr Seppo Yla-Herttuala

  377. 23. Catheter-Mediated Local Intramural Delivery of AdEC-SOD Inhibits Oxidative Stress and Reduces In-Stent Neointima by Accelerating Endothelial Cell Recovery in WHHL Rabbits Displaying Complex Human-Like Atherosclerotic Lesions

    Article • Molecular Therapy, January 2006, Elsevier

    Dr Seppo Yla-Herttuala

  378. 813. Targeted Delivery of Biotinylated Compounds by Lodavin™, LDL-Receptor – Avidin Fusion Protein, Expressing Lentivirus

    Article • Molecular Therapy, January 2006, Elsevier

    Dr Seppo Yla-Herttuala

  379. 160. Truncated Vesicular Stomatitis Virus G- Protein Improves Baculovirus Transduction Efficiency In Vitro and In Vivo

    Article • Molecular Therapy, January 2006, Elsevier

    Dr Seppo Yla-Herttuala

  380. 163. Baculovirus-Mediated Gene Transfer in New Zealand White Rabbit Skeletal Muscle

    Article • Molecular Therapy, January 2006, Elsevier

    Dr Seppo Yla-Herttuala

  381. 548. Cellular Defense Response in Transduced and Transfected Human Tumor and Primary Cell Lines

    Article • Molecular Therapy, January 2006, Elsevier

    Dr Seppo Yla-Herttuala

  382. Mo-W15:5 Hepatic overexpression of oxysterol binding protein(OSBP) results in hypertriglyceridemia

    Article • Atherosclerosis Supplements, January 2006, Elsevier

    Dr Seppo Yla-Herttuala

  383. CMR 2005: 12.06: Ultra-small iron oxide nanoparticle (USPIO)-labeled baculoviruses as novel MRI agents for imaging viral vector biodistributionin vivo

    Article • Contrast Media & Molecular Imaging, January 2006, Wiley

    Dr Seppo Yla-Herttuala

  384. Blood Flow Remodels Growing Vasculature During Vascular Endothelial Growth Factor Gene Therapy and Determines Between Capillary Arterialization and Sprouting Angiogenesis

    Article • Circulation, December 2005, Wolters Kluwer Health

    Dr Seppo Yla-Herttuala

  385. Autoantibodies against oxidized LDL are associated with severe chest pain attacks in patients with coronary heart disease

    Article • Free Radical Biology and Medicine, December 2005, Elsevier

    Dr Seppo Yla-Herttuala

  386. Adenovirus-Mediated Gene Transfer of Placental Growth Factor to Perivascular Tissue Induces Angiogenesis via Upregulation of the Expression of Endogenous Vascular Endothelial Growth Factor-A

    Article • Human Gene Therapy, December 2005, Mary Ann Liebert Inc

    Dr Seppo Yla-Herttuala

  387. Gene Transfer as a Tool to Induce Therapeutic Vascular Growth in Plastic Surgery

    Article • Handchirurgie · Mikrochirurgie · Plastische Chirurgie, December 2005, Thieme Publishing Group

    Dr Seppo Yla-Herttuala

  388. Adenovirus-Mediated Gene Transfer of Placental Growth Factor to Perivascular Tissue Induces Angiogenesis via Upregulation of the Expression of Endogenous Vascular Endothelial Growth Factor-A

    Article • Human Gene Therapy, November 2005, Mary Ann Liebert Inc

    Dr Seppo Yla-Herttuala

  389. Truncated vesicular stomatitis virus G protein improves baculovirus transduction efficiency in vitro and in vivo

    Article • Gene Therapy, November 2005, Nature

    Dr Seppo Yla-Herttuala

  390. VEGF-A, VEGF-D and VEGF-DDeltaNDeltaC induced intimal hyperplasia in carotid arteries

    Article • European Journal of Clinical Investigation, November 2005, Wiley

    Dr Seppo Yla-Herttuala

  391. Antibodies against oxidized LDL and cardiolipin and mortality in patients with coronary heart disease

    Article • Atherosclerosis, November 2005, Elsevier

    Dr Seppo Yla-Herttuala

  392. Gene Therapy for Malignant Glioma: Current Clinical Status

    Article • Molecular Therapy, October 2005, Elsevier

    Dr Seppo Yla-Herttuala

  393. Gene Transfers of Vascular Endothelial Growth Factor-A, Vascular Endothelial Growth Factor-B, Vascular Endothelial Growth Factor-C, and Vascular Endothelial Growth Factor-D Have No Effects on Atherosclerosis in Hypercholesterolemic Low-Density Lipoprot...

    Article • Circulation, August 2005, Wolters Kluwer Health

    Dr Seppo Yla-Herttuala

  394. Human gene therapy and imaging: cardiology

    Article • European Journal of Nuclear Medicine and Molecular Imaging, August 2005, Springer Science + Business Media

    Dr Seppo Yla-Herttuala

  395. Periadventitial angiopoietin 1 gene transfer induces angiogenesis in rabbit carotid arteries

    Article • Gene Therapy, August 2005, Nature

    Dr Seppo Yla-Herttuala

  396. Clinical significance of apoptotic index in non-small cell lung cancer: correlation with p53, mdm2, pRb and p21WAF1/CIP1 protein expression

    Article • Journal of Cancer Research and Clinical Oncology, July 2005, Springer Science + Business Media

    Dr Seppo Yla-Herttuala

  397. Tumor suppressor and growth regulatory genes are overexpressed in severe early-onset preeclampsia - an array study on case-specific human preeclamptic placental tissue

    Article • Acta Obstetricia Et Gynecologica Scandinavica, July 2005, Wiley

    Dr Seppo Yla-Herttuala

  398. Dual Role of Vascular Endothelial Growth Factor in Experimental Obliterative Bronchiolitis

    Article • American Review of Respiratory Disease, June 2005, American Thoracic Society

    Dr Seppo Yla-Herttuala, Dr Michael Jeltsch

  399. Angiopoietin-1 promotes lymphatic sprouting and hyperplasia

    Article • Blood, June 2005, American Society of Hematology

    Dr Seppo Yla-Herttuala

  400. Stabilized HIF-1  is superior to VEGF for angiogenesis in skeletal muscle via adeno-associated virus gene transfer

    Article • The FASEB Journal, June 2005, Federation of American Societies For Experimental Biology (FASEB)

    Dr Seppo Yla-Herttuala

  401. Vascular Oligonucleotide Transfer Facilitated by a Polymer-Coated Stent

    Article • Human Gene Therapy, June 2005, Mary Ann Liebert Inc

    Dr Seppo Yla-Herttuala

  402. Analysis of gene and protein expression during monocyte-macrophage differentiation and cholesterol loading—cDNA and protein array study

    Article • Atherosclerosis, June 2005, Elsevier

    Dr Seppo Yla-Herttuala

  403. Vascular Endothelial Cell Growth Factor Receptor 3-Mediated Activation of Lymphatic Endothelium Is Crucial for Tumor Cell Entry and Spread via Lymphatic Vessels

    Article • Cancer Research, June 2005, American Association for Cancer Research (AACR)

    Dr Seppo Yla-Herttuala, Dr Michael Jeltsch

  404. What have we learnt about microarray analyses of atherogenesis?

    Article • Current Opinion in Lipidology, April 2005, Wolters Kluwer Health

    Dr Seppo Yla-Herttuala

  405. Gene transfer using the mature form of VEGF-D reduces neointimal thickening through nitric oxide-dependent mechanism

    Article • Gene Therapy, March 2005, Nature

    PhD Mikko P Turunen, Dr Seppo Yla-Herttuala

  406. Improvement in Nuclear Entry and Transgene Expression of Baculoviruses by Disintegration of Microtubules in Human Hepatocytes

    Article • Journal of Virology, March 2005, ASM Journals

    Dr Seppo Yla-Herttuala

  407. Avidin Fusion Protein Strategies in Targeted Drug and Gene Delivery

    Article • Letters in Drug Design & Discovery, March 2005, Bentham Science Publishers

    Dr Seppo Yla-Herttuala

  408. Vascular endothelial growth factor (VEGF) gene transfer enhances surgical revascularization of necrotic bone

    Article • Journal of Orthopaedic Research®, March 2005, Wiley

    Dr Seppo Yla-Herttuala

  409. Intravascular adenovirus-mediated lipoprotein-associated phospholipase A2 gene transfer reduces neointima formation in balloon-denuded rabbit aorta

    Article • Atherosclerosis, March 2005, Elsevier

    Dr Seppo Yla-Herttuala

  410. A multipurpose vector system for the screening of libraries in bacteria, insect and mammalian cells and expression in vivo

    Article • Nucleic Acids Research, February 2005, Oxford University Press (OUP)

    Dr Seppo Yla-Herttuala

  411. Growth factor-induced therapeutic angiogenesis and arteriogenesis in the heart?gene therapy

    Article • Cardiovascular Research, February 2005, European Society of Cardiology

    Dr Seppo Yla-Herttuala

  412. Pathogenesis of persistent lymphatic vessel hyperplasia in chronic airway inflammation

    Article • Journal of Clinical Investigation, January 2005, American Society for Clinical Investigation

    Dr Seppo Yla-Herttuala, Dr Michael Jeltsch

  413. Pathogenesis of persistent lymphatic vessel hyperplasia in chronic airway inflammation

    Article • Journal of Clinical Investigation, January 2005, American Society for Clinical Investigation

    Dr Seppo Yla-Herttuala

  414. Cardiovascular gene therapy

    Article • January 2005, Wiley

    Dr Seppo Yla-Herttuala

  415. Periadventitial angiopoietin-1 gene transfer induces angiogenesis in rabbit carotid arteries

    Article • Gene Therapy, January 2005, Nature

    Dr Seppo Yla-Herttuala

  416. Tissue Inhibitor of Metalloproteinase 1 Adenoviral Gene Therapy Alone Is Equally Effective in Reducing Restenosis as Combination Gene Therapy in a Rabbit Restenosis Model

    Article • Journal of Vascular Research, January 2005, Karger Publishers

    PhD Mikko P Turunen, Dr Seppo Yla-Herttuala

  417. Genetics, genomics and proteomics in atherosclerosis research

    Article • Annals of Medicine, January 2005, Taylor & Francis

    Dr Seppo Yla-Herttuala

  418. Tumor suppressor and growth regulatory genes are overexpressed in severe early-onset preeclampsia - an array study on case-specific human preeclamptic placental tissue

    Article • Acta Obstetricia Et Gynecologica Scandinavica, January 2005, Wiley

    Dr Seppo Yla-Herttuala

  419. Gene Therapy of Atherosclerosis

    Article • January 2005, Springer Science + Business Media

    Dr Seppo Yla-Herttuala

  420. Localization of m2 muscarinic receptor protein in parvalbumin and calretinin containing cells of the adult rat entorhinal cortex using two complementary methods

    Article • Neuroscience, January 2005, Elsevier

    Dr Seppo Yla-Herttuala

  421. Efficient production of active chicken avidin using a bacterial signal peptide inEscherichia coli

    Article • Biochemical Journal, December 2004, Portland Press Ltd.

    Dr Vesa P Hytönen, Dr Seppo Yla-Herttuala

  422. Gene Therapy for Ischemic Cardiovascular Diseases: Some Lessons Learned from the First Clinical Trials

    Article • Trends in Cardiovascular Medicine, November 2004, Elsevier

    Dr Seppo Yla-Herttuala

  423. AdvHSV-tk gene therapy with intravenous ganciclovir improves survival in human malignant glioma: a randomised, controlled study

    Article • Molecular Therapy, November 2004, Elsevier

    Dr Seppo Yla-Herttuala

  424. Acute Respiratory Viral Infections Aggravate Arterial Endothelial Dysfunction in Children With Type 1 Diabetes

    Article • Diabetes Care, October 2004, American Diabetes Association

    Dr Seppo Yla-Herttuala

  425. Angiogenesis-Dependent and Independent Phases of Intimal Hyperplasia

    Article • Circulation, October 2004, Wolters Kluwer Health

    Dr Seppo Yla-Herttuala

  426. Vascular endothelial growth factor-C gene therapy restores lymphatic flow across incision wounds

    Article • The FASEB Journal, September 2004, Federation of American Societies For Experimental Biology (FASEB)

    Dr Seppo Yla-Herttuala

  427. Introduction

    Article • European Heart Journal Supplements, September 2004, Oxford University Press (OUP)

    Dr Seppo Yla-Herttuala

  428. Defective valves and abnormal mural cell recruitment underlie lymphatic vascular failure in lymphedema distichiasis

    Article • Nature Reports Stem Cells, August 2004, Nature

    Dr Seppo Yla-Herttuala

  429. Cancer gene therapy — current status in the clinics

    Article • Gene Therapy and Regulation, August 2004, Brill

    Dr Seppo Yla-Herttuala

  430. Optimized self-excising Cre-expression cassette for mammalian cells

    Article • Biochemical and Biophysical Research Communications, July 2004, Elsevier

    Dr Seppo Yla-Herttuala

  431. Therapeutic angiogenesis

    Article • International Congress Series, May 2004, Elsevier

    Dr Seppo Yla-Herttuala

  432. HIF-VEGF-VEGFR-2, TNF-α and IGF pathways are upregulated in critical human skeletal muscle ischemia as studied with DNA array

    Article • Atherosclerosis, May 2004, Elsevier

    Dr Seppo Yla-Herttuala

  433. Gene transfer into rabbit arteries with adeno-associated virus and adenovirus vectors

    Article • The Journal of Gene Medicine, May 2004, Wiley

    Dr Seppo Yla-Herttuala

  434. Granulocyte transmigration through the endothelium is regulated by the oxidase activity of vascular adhesion protein-1 (VAP-1)

    Article • Blood, May 2004, American Society of Hematology

    Dr Seppo Yla-Herttuala

  435. Adenovirus-mediated gene transfer of Lp-PLA2 reduces LDL degradation and foam cell formation in vitro

    Article • Journal of Lipid Research, April 2004, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Seppo Yla-Herttuala

  436. Long-Term Lowering of Plasma Cholesterol Levels in LDL-Receptor-Deficient WHHL Rabbits by Gene Therapy

    Article • Molecular Therapy, April 2004, Elsevier

    Dr Seppo Yla-Herttuala

  437. M.503 Hypercholesterolemia prevents myocardial damage without affecting contractility and preconditioning in model of Guinea pigs papillary muscle subjected to hypoxia-reoxygenation injury

    Article • Atherosclerosis Supplements, April 2004, Elsevier

    Dr Seppo Yla-Herttuala

  438. Water diffusion in a rat glioma during ganciclovir‐thymidine kinase gene therapy‐induced programmed cell death in vivo: Correlation with cell density

    Article • Journal of Magnetic Resonance Imaging, March 2004, Wiley

    Professor Risto A Kauppinen, Dr Seppo Yla-Herttuala

  439. Feline immunodeficiency virus and retrovirus-mediated adventitial ex vivo gene transfer to rabbit carotid artery using autologous vascular smooth muscle cells

    Article • Journal of Molecular and Cellular Cardiology, March 2004, Elsevier

    Dr Seppo Yla-Herttuala

  440. Oral Imatinib Mesylate (STI571/Gleevec) Improves the Efficacy of Local Intravascular Vascular Endothelial Growth Factor-C Gene Transfer in Reducing Neointimal Growth in Hypercholesterolemic Rabbits

    Article • Circulation, March 2004, Wolters Kluwer Health

    Dr Seppo Yla-Herttuala

  441. Adenoviral Catheter-Mediated Intramyocardial Gene Transfer Using the Mature Form of Vascular Endothelial Growth Factor-D Induces Transmural Angiogenesis in Porcine Heart

    Article • Circulation, February 2004, Wolters Kluwer Health

    Dr Seppo Yla-Herttuala

  442. Gene Therapy for Cardiovascular Diseases

    Article • Current Pharmaceutical Design, February 2004, Bentham Science Publishers

    Dr Seppo Yla-Herttuala

  443. Faculty of 1000 evaluation for Generation of viable cholesterol-free mice.

    Article • February 2004, Faculty of 1000, Ltd.

    Dr Seppo Yla-Herttuala

  444. Faculty of 1000 evaluation for Restriction enzyme-generated siRNA (REGS) vectors and libraries.

    Article • February 2004, Faculty of 1000, Ltd.

    Dr Seppo Yla-Herttuala

  445. Enhanced Gene Delivery by Avidin-Displaying Baculovirus

    Article • Molecular Therapy, February 2004, Elsevier

    Dr Seppo Yla-Herttuala

  446. Adventitial Angiogenesis Drives Neointima Formation

    Article • Clinical Science, February 2004, Portland Press Ltd.

    Dr Seppo Yla-Herttuala

  447. VEGF-C induces collateral formation in ischaemic porcine heart model

    Article • The Journal of Heart and Lung Transplantation, February 2004, Elsevier

    Dr Seppo Yla-Herttuala

  448. Inhibition of basal and interleukin-1-induced VCAM-1 expression by phospholipid hydroperoxide glutathione peroxidase and 15-lipoxygenase in rabbit aortic smooth muscle cells

    Article • Free Radical Biology and Medicine, January 2004, Elsevier

    Dr Seppo Yla-Herttuala

  449. Gene Transfer for Therapeutic Vascular Growth in Myocardial and Peripheral Ischemia

    Article • January 2004, Elsevier

    Dr Seppo Yla-Herttuala

  450. Fetal membranes act as a barrier for adenoviruses: gene transfer into exocoelomic cavity of rat fetuses does not affect cells in the fetus

    Article • American Journal of Obstetrics and Gynecology, January 2004, Elsevier

    Dr Seppo Yla-Herttuala

  451. Genetic alterations in the peritumoral stromal cells of malignant and borderline epithelial ovarian tumors as indicated by allelic imbalance on chromosome 3p

    Article • International Journal of Cancer, December 2003, Wiley

    Dr Seppo Yla-Herttuala

  452. Baculovirus-mediated Gene Transfer

    Article • December 2003, Taylor & Francis

    Dr Seppo Yla-Herttuala

  453. Effect of adventitial VEGF165 gene transfer on vascular thickening after coronary artery balloon injury

    Article • Cardiovascular Research, December 2003, European Society of Cardiology

    Dr Seppo Yla-Herttuala

  454. VEGF Protein in Human Ischemic Skeletal Muscle

    Article • American Journal Of Pathology, December 2003, Elsevier

    Dr Seppo Yla-Herttuala

  455. Adeno-associated virus-mediated gene transfer of a secreted decoy human macrophage scavenger receptor reduces atherosclerotic lesion formation in LDL receptor knockout mice

    Article • Molecular Therapy, December 2003, Elsevier

    Dr Seppo Yla-Herttuala

  456. Targeting of biotinylated compounds to its target tissue using a low-density lipoprotein receptor–avidin fusion protein

    Article • Gene Therapy, December 2003, Nature

    Dr Seppo Yla-Herttuala

  457. Production of functional recombinant tyrosine hydroxylase by the BPV-1 expression plasmids in the cell cultures

    Article • Plasmid, November 2003, Elsevier

    Professor Mart Ustav, Dr Seppo Yla-Herttuala

  458. Baculovirus capsid display: a novel tool for transduction imaging

    Article • Molecular Therapy, November 2003, Elsevier

    Dr Seppo Yla-Herttuala

  459. Evolving revascularization approaches for myocardial ischemia

    Article • The American Journal of Cardiology, November 2003, Elsevier

    Dr Seppo Yla-Herttuala

  460. Faculty of 1000 evaluation for Zinc-finger protein-targeted gene regulation: genomewide single-gene specificity.

    Article • October 2003, Faculty of 1000, Ltd.

    Dr Seppo Yla-Herttuala

  461. Angiogenic Responses of Vascular Endothelial Growth Factors in Periadventitial Tissue

    Article • Human Gene Therapy, October 2003, Mary Ann Liebert Inc

    Dr Seppo Yla-Herttuala

  462. Vascular endothelial growth factor-D expression in human atherosclerotic lesions

    Article • Cardiovascular Research, October 2003, European Society of Cardiology

    Dr Seppo Yla-Herttuala

  463. Percutaneous transcoronary venous access for cellular cardiomyoplasty

    Article • The Lancet, October 2003, Elsevier

    Dr Seppo Yla-Herttuala

  464. Gene Expression in Macrophage-Rich Inflammatory Cell Infiltrates in Human Atherosclerotic Lesions as Studied by Laser Microdissection and DNA Array: Overexpression of HMG-CoA Reductase, Colony Stimulating Factor Receptors, CD11A/CD18 Integrins, and Int...

    Article • Arteriosclerosis Thrombosis and Vascular Biology, September 2003, Wolters Kluwer Health

    Dr Seppo Yla-Herttuala

  465. Metabolite Changes in BT4C Rat Gliomas Undergoing Ganciclovir-Thymidine Kinase Gene Therapy-induced Programmed Cell Death as Studied by 1H NMR Spectroscopy in Vivo, ex Vivo, and in Vitro

    Article • Journal of Biological Chemistry, September 2003, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Seppo Yla-Herttuala

  466. Angiopoietin-regulated recruitment of vascular smooth muscle cells by endothelial-derived heparin binding EGF-like growth factor

    Article • The FASEB Journal, September 2003, Federation of American Societies For Experimental Biology (FASEB)

    Dr Seppo Yla-Herttuala

  467. DNA Methylation, Smooth Muscle Cells, and Atherogenesis

    Article • Arteriosclerosis Thrombosis and Vascular Biology, August 2003, Wolters Kluwer Health

    Dr Seppo Yla-Herttuala

  468. Adenovirus-mediated gene transfer of a secreted decoy human macrophage scavenger receptor (SR-AI) in LDL receptor knock-out mice

    Article • Atherosclerosis, July 2003, Elsevier

    Dr Seppo Yla-Herttuala

  469. Co-Infection with Chlamydia pneumoniae and Helicobacter pylori Results in Vascular Endothelial Dysfunction and Enhanced VCAM-1 Expression in ApoE-Knockout Mice

    Article • Journal of Vascular Research, June 2003, Karger Publishers

    Dr Seppo Yla-Herttuala

  470. Gene transfer as a tool to induce therapeutic vascular growth

    Article • Nature Reports Stem Cells, June 2003, Nature

    Dr Seppo Yla-Herttuala

  471. VEGF-D Is the Strongest Angiogenic and Lymphangiogenic Effector Among VEGFs Delivered Into Skeletal Muscle via Adenoviruses

    Article • Circulation Research, April 2003, Wolters Kluwer Health

    Dr Seppo Yla-Herttuala

  472. Faculty of 1000 evaluation for SHED: stem cells from human exfoliated deciduous teeth.

    Article • April 2003, Faculty of 1000, Ltd.

    Dr Seppo Yla-Herttuala

  473. Cardiovascular Gene Therapy

    Article • April 2003, Taylor & Francis

    PhD Mikko P Turunen, Dr Seppo Yla-Herttuala

  474. Adenovirus-mediated VEGF-A gene transfer induces bone formation in vivo

    Article • The FASEB Journal, April 2003, Federation of American Societies For Experimental Biology (FASEB)

    Dr Seppo Yla-Herttuala

  475. Transfection of oocytes and other types of ovarian cells in rabbits after direct injection into uterine arteries of adenoviruses and plasmid/liposomes

    Article • Gene Therapy, April 2003, Nature

    Dr Seppo Yla-Herttuala

  476. Adenoviral VEGF-A gene transfer induces angiogenesis and promotes bone formation in healing osseous tissues

    Article • The Journal of Gene Medicine, March 2003, Wiley

    Dr Seppo Yla-Herttuala

  477. Acute infections in children are accompanied by oxidative modification of LDL and decrease of HDL cholesterol, and are followed by thickening of carotid intima–media

    Article • European Heart Journal, March 2003, European Society of Cardiology

    Dr Seppo Yla-Herttuala

  478. Doxycycline-regulated lentiviral vector system with a novel reverse transactivator rtTA2S-M2 shows a tight control of gene expression in vitro and in vivo

    Article • Gene Therapy, March 2003, Nature

    Dr Seppo Yla-Herttuala

  479. Angiopoietin-1 Protects Against the Development of Cardiac Allograft Arteriosclerosis

    Article • Circulation, February 2003, Wolters Kluwer Health

    Dr Seppo Yla-Herttuala

  480. Adverse effects of gene therapy: Hero or villain?

    Article • Gene Therapy, February 2003, Nature

    Dr Seppo Yla-Herttuala

  481. Association of the PRO12ALA polymorphism of the PPAR-γ2 gene with oxidized low-density lipoprotein and cardiolipin autoantibodies in nondiabetic and type 2 diabetic subjects

    Article • Metabolism, February 2003, Elsevier

    Dr Seppo Yla-Herttuala

  482. Human Gene Therapy: Current Opportunities and Future Trends

    Article • January 2003, Springer Science + Business Media

    Dr Seppo Yla-Herttuala

  483. Patterns of oxidized epitopes, but not NF-κB expression, change during atherogenesis in WHHL rabbits

    Article • Atherosclerosis, January 2003, Elsevier

    Dr Seppo Yla-Herttuala

  484. Angiogenesis Clinical Trials

    Article • January 2003, Springer Science + Business Media

    Dr Seppo Yla-Herttuala

  485. 1WS05-1 Preclinical and clinical experience from cardiovascular gene therapy with VEGF

    Article • Atherosclerosis Supplements, January 2003, Elsevier

    Dr Seppo Yla-Herttuala

  486. A Stable Bis-Allyloxycarbonyl Biotin Aldehyde Derivative for Biotinylation via Reductive Alkylation:  Application to the Synthesis of a Biotinylated Doxorubicin Derivative

    Article • Bioconjugate Chemistry, January 2003, American Chemical Society (ACS)

    Dr Seppo Yla-Herttuala, David Selwood

  487. Promoter Polymorphisms -359T/C and -303A/G of the Catalytic Subunit p110  Gene of Human Phosphatidylinositol 3-Kinase Are Not Associated With Insulin Secretion or Insulin Sensitivity in Finnish Subjects

    Article • Diabetes Care, January 2003, American Diabetes Association

    Dr Seppo Yla-Herttuala

  488. Baculoviruses exhibit restricted cell type specificity in rat brain: a comparison of baculovirus- and adenovirus-mediated intracerebral gene transfer in vivo

    Article • Gene Therapy, November 2002, Nature

    Dr Seppo Yla-Herttuala

  489. Cell-Type-Specific Characteristics Modulate the Transduction Efficiency of Adeno-Associated Virus Type 2 and Restrain Infection of Endothelial Cells

    Article • Journal of Virology, November 2002, ASM Journals

    Dr Seppo Yla-Herttuala

  490. Post-intervention vessel remodeling

    Article • Gene Therapy, November 2002, Springer Science + Business Media

    Dr Seppo Yla-Herttuala

  491. Changes in gene expression in atherosclerotic plaques analyzed using DNA array

    Article • Atherosclerosis, November 2002, Elsevier

    Dr Seppo Yla-Herttuala

  492. Adenovirus-mediated herpes simplex virus thymidine kinase gene therapy in BT4C rat glioma model

    Article • Cancer Gene Therapy, October 2002, Springer Science + Business Media

    Professor Risto A Kauppinen, Dr Seppo Yla-Herttuala

  493. The combination of HSV-tk and endostatin gene therapy eradicates orthotopic human renal cell carcinomas in nude mice

    Article • Cancer Gene Therapy, October 2002, Springer Science + Business Media

    Professor Risto A Kauppinen, Dr Seppo Yla-Herttuala

  494. Lymphangiogenic Gene Therapy With Minimal Blood Vascular Side Effects

    Article • The Journal of Experimental Medicine, September 2002, Rockefeller University Press

    Dr Seppo Yla-Herttuala

  495. Adenovirus-Mediated Extracellular Superoxide Dismutase Gene Therapy Reduces Neointima Formation in Balloon-Denuded Rabbit Aorta

    Article • Circulation, September 2002, Wolters Kluwer Health

    Dr Seppo Yla-Herttuala

  496. Lymphatic endothelial reprogramming of vascular endothelial cells by the Prox-1 homeobox transcription factor

    Article • The EMBO Journal, September 2002, Wiley

    Dr Seppo Yla-Herttuala

  497. Peptide-Retargeted Adenovirus Encoding a Tissue Inhibitor of Metalloproteinase-1 Decreases Restenosis after Intravascular Gene Transfer

    Article • Molecular Therapy, September 2002, Elsevier

    Dr Seppo Yla-Herttuala

  498. Comparison of the effects of α-tocopherol, ubiquinone-10 and probucol at therapeutic doses on atherosclerosis in WHHL rabbits

    Article • Atherosclerosis, August 2002, Elsevier

    Dr Seppo Yla-Herttuala

  499. Adenoviral VEGF-C overexpression induces blood vessel enlargement, tortuosity, and leakiness but no sprouting angiogenesis in the skin or mucous membranes

    Article • The FASEB Journal, July 2002, Federation of American Societies For Experimental Biology (FASEB)

    Dr Seppo Yla-Herttuala, Dr Michael Jeltsch

  500. Increased Vascularity Detected by Digital Subtraction Angiography after VEGF Gene Transfer to Human Lower Limb Artery: A Randomized, Placebo-Controlled, Double-Blinded Phase II Study

    Article • Molecular Therapy, July 2002, Elsevier

    Dr Seppo Yla-Herttuala

  501. Suppression of Tumor Lymphangiogenesis and Lymph Node Metastasis by Blocking Vascular Endothelial Growth Factor Receptor 3 Signaling

    Article • JNCI Journal of the National Cancer Institute, June 2002, Oxford University Press (OUP)

    Dr Seppo Yla-Herttuala

  502. Evaluation of angiogenesis and side effects in ischemic rabbit hindlimbs after intramuscular injection of adenoviral vectors encoding VEGF andLacZ

    Article • The Journal of Gene Medicine, May 2002, Wiley

    Dr Seppo Yla-Herttuala

  503. Vascular Endothelial Growth Factor Enhances Cardiac Allograft Arteriosclerosis

    Article • Circulation, May 2002, Wolters Kluwer Health

    Dr Seppo Yla-Herttuala

  504. Gene transfer to human placenta ex vivo: A novel application of dual perfusion of human placental cotyledon

    Article • American Journal of Obstetrics and Gynecology, May 2002, Elsevier

    Dr Seppo Yla-Herttuala

  505. Genes Involved in Atherosclerosis

    Article • Nephron Experimental Nephrology, April 2002, Karger Publishers

    Dr Seppo Yla-Herttuala

  506. Early gene therapy–induced apoptotic response in BT4C gliomas by magnetic resonance relaxation contrast T1 in the rotating frame

    Article • Cancer Gene Therapy, April 2002, Springer Science + Business Media

    Professor Risto A Kauppinen, Dr Seppo Yla-Herttuala

  507. Expression of Vascular Endothelial Growth Factor and Vascular Endothelial Growth Factor Receptor-2 (KDR/Flk-1) in Ischemic Skeletal Muscle and Its Regeneration

    Article • American Journal Of Pathology, April 2002, Elsevier

    Professor Risto A Kauppinen, PhD Mikko P Turunen, Dr Seppo Yla-Herttuala

  508. Faculty of 1000 evaluation for Prions in skeletal muscle.

    Article • March 2002, Faculty of 1000, Ltd.

    Dr Seppo Yla-Herttuala

  509. Combination of VEGF-C gene transfer and treatment with the PDGF receptor kinase inhibitor STI571 leads to persistent reduction in neointima formation in balloon-denunded rabbit aorta

    Article • Journal of the American College of Cardiology, March 2002, Elsevier

    PhD Mikko P Turunen, Dr Seppo Yla-Herttuala

  510. Escherichia coli DNA Contamination in AmpliTaq Gold Polymerase Interferes with TaqMan Analysis of lacZ

    Article • Molecular Therapy, March 2002, Elsevier

    Dr Seppo Yla-Herttuala

  511. Faculty of 1000 evaluation for Parthenogenetic stem cells in nonhuman primates.

    Article • February 2002, Faculty of 1000, Ltd.

    Dr Seppo Yla-Herttuala

  512. DNA hypomethylation and methyltransferase expression in atherosclerotic lesions

    Article • Vascular Medicine, February 2002, SAGE Publications

    PhD Mikko P Turunen, Dr Seppo Yla-Herttuala

  513. Apolipoprotein E and colon cancer

    Article • European Journal of Internal Medicine, February 2002, Elsevier

    Dr Seppo Yla-Herttuala

  514. The use of low-molecular-weight PEIs as gene carriers in the monkey fibroblastoma and rabbit smooth muscle cell cultures

    Article • The Journal of Gene Medicine, January 2002, Wiley

    Dr Seppo Yla-Herttuala

  515. [18] Gene therapy methods in cardiovascular diseases

    Article • January 2002, Elsevier

    PhD Mikko P Turunen, Dr Seppo Yla-Herttuala

  516. Cloning and Characterization of Soluble Decoy Receptors

    Article • January 2002, Elsevier

    Dr Seppo Yla-Herttuala

  517. Improvement in Adenoviral Gene Transfer Efficiency after Preincubation at +37°C in Vitro and in Vivo

    Article • Molecular Therapy, January 2002, Elsevier

    Dr Seppo Yla-Herttuala

  518. Gene Therapy for Restenosis

    Article • Drugs, January 2002, Springer Science + Business Media

    Dr Seppo Yla-Herttuala

  519. Cloning and Characterization of Scavidin, a Fusion Protein for the Targeted Delivery of Biotinylated Molecules

    Article • Journal of Biological Chemistry, December 2001, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Seppo Yla-Herttuala

  520. Gene therapy for coronary heart disease

    Article • Journal of Internal Medicine, November 2001, Wiley

    Dr Seppo Yla-Herttuala

  521. A model for gene therapy of human hereditary lymphedema

    Article • Proceedings of the National Academy of Sciences, October 2001, Proceedings of the National Academy of Sciences

    Dr Seppo Yla-Herttuala

  522. Evaluation and characterization of EIA measuring autoantibodies against oxidized LDL

    Article • Free Radical Biology and Medicine, September 2001, Elsevier

    Dr Seppo Yla-Herttuala

  523. Extracellular Superoxide Dismutase Deficiency and Atherosclerosis in Mice

    Article • Arteriosclerosis Thrombosis and Vascular Biology, September 2001, Wolters Kluwer Health

    Dr Seppo Yla-Herttuala

  524. Gene therapy for therapeutic angiogenesis in critically ischaemic lower limb - on the way to the clinic

    Article • European Journal of Clinical Investigation, August 2001, Wiley

    Dr Seppo Yla-Herttuala

  525. HSV-tk gene therapy for human renal cell carcinoma in nude mice

    Article • Cancer Gene Therapy, July 2001, Springer Science + Business Media

    Professor Risto A Kauppinen, Dr Seppo Yla-Herttuala

  526. Gene Transfer of Extracellular Superoxide Dismutase to Atherosclerotic Mice

    Article • Antioxidants & Redox Signaling, June 2001, Mary Ann Liebert Inc

    Dr Seppo Yla-Herttuala

  527. Linked Chromosome 16q13 Chemokines, Macrophage-Derived Chemokine, Fractalkine, and Thymus- and Activation-Regulated Chemokine, Are Expressed in Human Atherosclerotic Lesions

    Article • Arteriosclerosis Thrombosis and Vascular Biology, June 2001, Wolters Kluwer Health

    Dr Seppo Yla-Herttuala

  528. Angiographically guided utero-placental gene transfer in rabbits with adenoviruses, plasmid/liposomes and plasmid/polyethyleneimine complexes

    Article • Gene Therapy, May 2001, Nature

    PhD Mikko P Turunen, Dr Seppo Yla-Herttuala

  529. Adenoviral Expression of Vascular Endothelial Growth Factor-C Induces Lymphangiogenesis in the Skin

    Article • Circulation Research, March 2001, Wolters Kluwer Health

    Dr Seppo Yla-Herttuala

  530. Rabbit atherosclerotic lesions express scavenger receptor AIII mRNA, a naturally occurring splice variant that encodes a non-functional, dominant negative form of the macrophage scavenger receptor

    Article • Atherosclerosis, February 2001, Elsevier

    Dr Seppo Yla-Herttuala

  531. Article • Nature Reports Stem Cells, February 2001, Nature

    Dr Seppo Yla-Herttuala

  532. Optimizedin situ PCR method for the detection of gene transfer vector in histological sections

    Article • The Journal of Gene Medicine, January 2001, Wiley

    PhD Mikko P Turunen, Dr Seppo Yla-Herttuala

  533. Technical and Clinical Aspects about Autoantibody Assays for Oxidized Low Density Lipoprotein

    Article • January 2001, Elsevier

    Dr Seppo Yla-Herttuala

  534. Clinical applications of vascular gene therapy

    Article • Current Cardiology Reports, January 2001, Springer Science + Business Media

    Dr Seppo Yla-Herttuala

  535. EC-SOD gene therapy reduces paracetamol-induced liver damage in mice

    Article • The Journal of Gene Medicine, January 2001, Wiley

    Dr Seppo Yla-Herttuala

  536. Biodistribution of adenoviral vector to nontarget tissues after local in vivo gene transfer to arterial wall using intravascular and periadventitial gene delivery methods

    Article • The FASEB Journal, November 2000, Federation of American Societies For Experimental Biology (FASEB)

    Dr Seppo Yla-Herttuala

  537. Thymidine Kinase Gene Therapy for Human Malignant Glioma, Using Replication-Deficient Retroviruses or Adenoviruses

    Article • Human Gene Therapy, November 2000, Mary Ann Liebert Inc

    Dr Seppo Yla-Herttuala

  538. Intravascular Adenovirus-Mediated VEGF-C Gene Transfer Reduces Neointima Formation in Balloon-Denuded Rabbit Aorta

    Article • Circulation, October 2000, Wolters Kluwer Health

    Dr Seppo Yla-Herttuala

  539. Macrophages, smooth muscle cells, endothelial cells, and T-cells express CD40 and CD40L in fatty streaks and more advanced human atherosclerotic lesions

    Article • Virchows Archiv, October 2000, Springer Science + Business Media

    Dr Seppo Yla-Herttuala

  540. Overexpression of PHGPx inhibits hydroperoxide-induced oxidation, NFκB activation and apoptosis and affects oxLDL-mediated proliferation of rabbit aortic smooth muscle cells

    Article • Atherosclerosis, October 2000, Elsevier

    Dr Seppo Yla-Herttuala

  541. Gene encoding the catalytic subunit p110beta of human phosphatidylinositol 3-kinase: cloning, genomic structure, and screening for variants in patients with type 2 diabetes

    Article • Diabetes, October 2000, American Diabetes Association

    Dr Seppo Yla-Herttuala

  542. Baculovirus-mediated periadventitial gene transfer to rabbit carotid artery

    Article • Gene Therapy, September 2000, Nature

    PhD Mikko P Turunen, Dr Seppo Yla-Herttuala

  543. Rabbit extracellular superoxide dismutase: expression and effect on LDL oxidation

    Article • Gene, August 2000, Elsevier

    Dr Seppo Yla-Herttuala

  544. Adventitial ex vivo gene transfer to rabbit carotid artery using autologous vascular smooth muscle cells

    Article • Atherosclerosis, July 2000, Elsevier

    PhD Mikko P Turunen, Dr Seppo Yla-Herttuala

  545. Gene expression in atherosclerotic lesions analyzed by DNA array

    Article • Atherosclerosis, July 2000, Elsevier

    Dr Seppo Yla-Herttuala

  546. Evaluation and characterization of ELISA measuring autoantibodies against oxidized low density lipoprotein

    Article • Atherosclerosis, July 2000, Elsevier

    Dr Seppo Yla-Herttuala

  547. VEGF gene transfer in the treatment of coronary heart disease and peripheral vascular disease

    Article • Atherosclerosis, July 2000, Elsevier

    Dr Seppo Yla-Herttuala

  548. Cholesterol increases DNA methylation in rabbit tissues

    Article • Atherosclerosis, July 2000, Elsevier

    Dr Seppo Yla-Herttuala

  549. Effect of extracellular superoxide dismutase on LDL oxidation

    Article • Atherosclerosis, July 2000, Elsevier

    Dr Seppo Yla-Herttuala

  550. Adenovirus mediated gene transfer of human 15-lipoxygenase in vitro and in vivo

    Article • Atherosclerosis, July 2000, Elsevier

    Dr Seppo Yla-Herttuala

  551. Secreted macrophage scavenger receptor gene transfer in LDL receptor knock-out mice reduces atherosclerotic lesion area

    Article • Atherosclerosis, July 2000, Elsevier

    Dr Seppo Yla-Herttuala

  552. Effect of mercury, iron and antioxidants on atherosclerosis in LDLR-deficient mice

    Article • Atherosclerosis, July 2000, Elsevier

    Dr Seppo Yla-Herttuala

  553. Regulation of low density lipoprotein receptor activity after retrovirus mediated gene transfer

    Article • Atherosclerosis, July 2000, Elsevier

    Dr Seppo Yla-Herttuala

  554. Stable scavenger receptor gene transfer leads to increased susceptibility to apoptosis in rabbit aortic smooth muscle cells

    Article • Atherosclerosis, July 2000, Elsevier

    Dr Seppo Yla-Herttuala

  555. PDGF-receptor-β antisense gene transfer decreases proliferation and PDGF binding of human primary smooth muscle cells

    Article • Atherosclerosis, July 2000, Elsevier

    Dr Seppo Yla-Herttuala

  556. Scavenger receptors are expressed on pseudoendothelium composed of smooth muscle cells in NZW rabbit aorta after balloon denudation

    Article • Atherosclerosis, July 2000, Elsevier

    Dr Seppo Yla-Herttuala

  557. Adenovirus-mediated extracellular superoxide dismutase gene transfer in vitro and in vivo

    Article • Atherosclerosis, July 2000, Elsevier

    Dr Seppo Yla-Herttuala

  558. Periadventitial lacZ gene transfer to pig carotid arteries using a biodegradable collagen collar or a wrap of collagen sheet with adenoviruses and plasmid-liposome complexes

    Article • Atherosclerosis, July 2000, Elsevier

    Dr Seppo Yla-Herttuala

  559. Vascular Protection : A Novel Nonangiogenic Cardiovascular Role for Vascular Endothelial Growth Factor

    Article • Arteriosclerosis Thrombosis and Vascular Biology, June 2000, Wolters Kluwer Health

    Dr Seppo Yla-Herttuala

  560. Herpes simplex virus thymidine kinase gene therapy in experimental rat BT4C glioma model: Effect of the percentage of thymidine kinase-positive glioma cells on treatment effect, survival time, and tissue reactions

    Article • Cancer Gene Therapy, May 2000, Nature

    Dr Seppo Yla-Herttuala

  561. Adenovirus-Mediated Gene Transfer of a Secreted Form of Human Macrophage Scavenger Receptor Inhibits Modified Low-Density Lipoprotein Degradation and Foam-Cell Formation in Macrophages

    Article • Circulation, March 2000, Wolters Kluwer Health

    Dr Seppo Yla-Herttuala

  562. Insights into the molecular pathogenesis of atherosclerosis and therapeutic strategies using gene transfer

    Article • Vascular Medicine, February 2000, SAGE Publications

    PhD Mikko P Turunen, Dr Seppo Yla-Herttuala

  563. Insights into the molecular pathogenesis of atherosclerosis and therapeutic strategies using gene transfer

    Article • Vascular Medicine, February 2000, SAGE Publications

    PhD Mikko P Turunen, Dr Seppo Yla-Herttuala

  564. Catheter-Mediated Vascular Endothelial Growth Factor Gene Transfer to Human Coronary Arteries after Angioplasty

    Article • Human Gene Therapy, January 2000, Mary Ann Liebert Inc

    Dr Seppo Yla-Herttuala

  565. lacZ-neoR transfected glioma cells in syngeneic rats: Growth pattern and characterization of the host immune response against cells transplanted inside and outside the cns

    Article • International Journal of Cancer, January 2000, Wiley

    Dr Seppo Yla-Herttuala

  566. lacZ-neoR transfected glioma cells in syngeneic rats: Growth pattern and characterization of the host immune response against cells transplanted inside and outside the cns

    Article • International Journal of Cancer, January 2000, Wiley

    Dr Seppo Yla-Herttuala

  567. Gene transfer to placenta

    Article • International Journal of Gynecology & Obstetrics, January 2000, Wiley

    PhD Mikko P Turunen, Dr Seppo Yla-Herttuala

  568. Cardiovascular gene therapy

    Article • The Lancet, January 2000, Elsevier

    Dr Seppo Yla-Herttuala

  569. Effects of Lipoxygenases on Gene Expression in Mammalian Cells

    Article • January 2000, Elsevier

    Dr Seppo Yla-Herttuala

  570. Gene therapy for the treatment of peripheral vascular disease and coronary artery disease

    Article • January 2000, Prous Science

    Dr Seppo Yla-Herttuala

  571. Autoantibodies Against Oxidized Low-Density Lipoprotein and Cardiolipin in Patients With Coronary Heart Disease

    Article • Arteriosclerosis Thrombosis and Vascular Biology, January 2000, Wolters Kluwer Health

    Dr Seppo Yla-Herttuala

  572. Retrovirus-Mediated, Stable Scavenger-Receptor Gene Transfer Leads to Functional Endocytotic Receptor Expression, Foam Cell Formation, and Increased Susceptibility to Apoptosis in Rabbit Aortic Smooth Muscle Cells

    Article • Arteriosclerosis Thrombosis and Vascular Biology, January 2000, Wolters Kluwer Health

    Dr Seppo Yla-Herttuala

  573. PeriadventitiallacZ gene transfer to pig carotid arteries using a biodegradable collagen collar or a wrap of collagen sheet with adenoviruses and plasmid-liposome complexes

    Article • The Journal of Gene Medicine, January 2000, Wiley

    Dr Seppo Yla-Herttuala

  574. Article • APOPTOSIS, January 2000, Springer Science + Business Media

    Dr Seppo Yla-Herttuala

  575. Functional genomics and DNA array techniques in atherosclerosis research

    Article • Current Opinion in Lipidology, December 1999, Wolters Kluwer Health

    Dr Seppo Yla-Herttuala

  576. Pathogenesis and treatment of atherosclerosis-related diseases

    Article • Current Opinion in Lipidology, December 1999, Wolters Kluwer Health

    Dr Seppo Yla-Herttuala

  577. Lipoprotein-Associated Phospholipase A2, Platelet-Activating Factor Acetylhydrolase, Is Expressed by Macrophages in Human and Rabbit Atherosclerotic Lesions

    Article • Arteriosclerosis Thrombosis and Vascular Biology, December 1999, Wolters Kluwer Health

    Dr Seppo Yla-Herttuala

  578. 1H MRS detects polyunsaturated fatty acid accumulation during gene therapy of glioma: Implications for the in vivo detection of apoptosis

    Article • Nature Reports Stem Cells, November 1999, Springer Science + Business Media

    Professor Risto A Kauppinen, Dr Seppo Yla-Herttuala

  579. IMPROVED GENE TRANSFER EFFICIENCY IN LIVER WITH VESICULAR STOMATITIS VIRUS G-PROTEIN PSEUDOTYPED RETROVIRUS AFTER PARTIAL LIVER RESECTION AND THYMIDINE KINASE-GANCICLOVIR PRE-TREATMENT

    Article • Pharmacological Research, November 1999, Elsevier

    Dr Seppo Yla-Herttuala

  580. Autoantibodies against oxidized LDL and endothelium-dependent vasodilation in insulin-dependent diabetes mellitus

    Article • Atherosclerosis, November 1999, Elsevier

    Dr Seppo Yla-Herttuala

  581. Gene therapy for atherosclerosis and atherosclerosis-related diseases

    Article • Current Atherosclerosis Reports, September 1999, Springer Science + Business Media

    Dr Seppo Yla-Herttuala

  582. Local Hypomethylation in Atherosclerosis Found in Rabbit ec-sod Gene

    Article • Arteriosclerosis Thrombosis and Vascular Biology, September 1999, Wolters Kluwer Health

    Dr Seppo Yla-Herttuala

  583. Low Efficacy of Gene Therapy for Rat BT4C Malignant Glioma Using Intra-Tumoural Transduction with Thymidine Kinase Retrovirus Packaging Cell Injections and Ganciclovir Treatment

    Article • Acta Neurochirurgica, August 1999, Springer Science + Business Media

    Dr Seppo Yla-Herttuala

  584. Gene therapy for angiogenesis, restenosis and related diseases

    Article • Experimental Gerontology, August 1999, Elsevier

    PhD Mikko P Turunen, Dr Seppo Yla-Herttuala

  585. Different apolipoprotein B breakdown patterns in models of oxidized low density lipoprotein

    Article • Life Sciences, July 1999, Elsevier

    Dr Seppo Yla-Herttuala

  586. Expression of inducible nitric oxide synthase in macrophages and smooth muscle cells in various types of human atherosclerotic lesions

    Article • Virchows Archiv, June 1999, Springer Science + Business Media

    Dr Seppo Yla-Herttuala

  587. Oxidized LDL and Atherogenesisa

    Article • Annals of the New York Academy of Sciences, June 1999, Wiley

    Dr Seppo Yla-Herttuala

  588. Rabbit extracellular superoxide dismutase inhibits LDL oxidation

    Article • Atherosclerosis, May 1999, Elsevier

    Dr Seppo Yla-Herttuala

  589. Metabolism of modified LDL and foam cell formation in murine macrophage-like raw 264 cells

    Article • Life Sciences, April 1999, Elsevier

    Dr Seppo Yla-Herttuala

  590. High Expression of Human 15-Lipoxygenase Induces NF-κB-Mediated Expression of Vascular Cell Adhesion Molecule 1, Intercellular Adhesion Molecule 1, and T-Cell Adhesion on Human Endothelial Cells

    Article • Antioxidants & Redox Signaling, March 1999, Mary Ann Liebert Inc

    Dr Seppo Yla-Herttuala

  591. Effect of vitamin E on endothelial vasodilator function in patients with hypercholesterolemia, chronic smoking or both

    Article • Journal of the American College of Cardiology, February 1999, Elsevier

    Dr Seppo Yla-Herttuala

  592. Efficient adventitial gene delivery to rabbit carotid artery with cationic polymer–plasmid complexes

    Article • Gene Therapy, January 1999, Nature

    PhD Mikko P Turunen, Dr Seppo Yla-Herttuala

  593. Vascular Gene Therapy — Early Clinical Results with Angiogenic Growth Factors

    Article • January 1999, Springer Science + Business Media

    Dr Seppo Yla-Herttuala

  594. Interactions of polymeric and liposomal gene delivery systems with extracellular glycosaminoglycans: physicochemical and transfection studies

    Article • Biochimica et Biophysica Acta (BBA) - Biomembranes, January 1999, Elsevier

    Dr Seppo Yla-Herttuala

  595. Autoantibodies Against Oxidized Low Density Lipoprotein in Patients With Angiographically Verified Coronary Artery Disease

    Article • Arteriosclerosis Thrombosis and Vascular Biology, January 1999, Wolters Kluwer Health

    Dr Seppo Yla-Herttuala

  596. Complement and anti-α-galactosyl natural antibody-mediated inactivation of murine retrovirus occurs in adult serum but not in umbilical cord serum

    Article • Gene Therapy, January 1999, Springer Science + Business Media

    Dr Seppo Yla-Herttuala

  597. Enhanced plasma cholesterol lowering effect of retrovirus-mediated LDL receptor gene transfer to WHHL rabbit liver after improved surgical technique and stimulation of hepatocyte proliferation by combined partial liver resection and thymidine kinase– g...

    Article • Gene Therapy, January 1999, Nature

    Dr Seppo Yla-Herttuala

  598. The atherosclerotic lesion: a dynamic landscape

    Article • Current Opinion in Lipidology, October 1998, Wolters Kluwer Health

    Dr Seppo Yla-Herttuala

  599. Vascular gene transfer for the treatment of restenosis and atherosclerosis

    Article • Current Opinion in Lipidology, October 1998, Wolters Kluwer Health

    Dr Seppo Yla-Herttuala

  600. β-Galactosidase Gene Transfer to Human Malignant GliomaIn VivoUsing Replication-Deficient Retroviruses and Adenoviruses

    Article • Human Gene Therapy, August 1998, Mary Ann Liebert Inc

    Dr Seppo Yla-Herttuala

  601. Is oxidized low‐density lipoprotein present in vivo?

    Article • Current Opinion in Lipidology, August 1998, Wolters Kluwer Health

    Dr Seppo Yla-Herttuala

  602. Intravascular Ultrasound and Magnetic Resonance Imaging in the Assessment of Atherosclerotic Lesions in Rabbit Aorta

    Article • Investigative Radiology, August 1998, Wolters Kluwer Health

    Dr Seppo Yla-Herttuala

  603. Adenovirus-Mediated Gene Transfer to Lower Limb Artery of Patients with Chronic Critical Leg Ischemia

    Article • Human Gene Therapy, July 1998, Mary Ann Liebert Inc

    Dr Seppo Yla-Herttuala

  604. Postmenopausal hormone replacement therapy and autoantibodies against oxidized LDL

    Article • Maturitas, June 1998, Elsevier

    Dr Seppo Yla-Herttuala

  605. Pathogenesis of atherosclerosis

    Article • Pathophysiology, June 1998, Elsevier

    Dr Seppo Yla-Herttuala

  606. Gene expression and atherosclerosis

    Article • Pathophysiology, June 1998, Elsevier

    Dr Seppo Yla-Herttuala

  607. Baseline Diene Conjugation in LDL Lipids as a Direct Measure of In Vivo LDL Oxidation

    Article • Clinical Biochemistry, June 1998, Elsevier

    Dr Seppo Yla-Herttuala, Prof Tommi Vasankari

  608. Vascular endothelial growth factor (VEGF) gene therapy in the prevention of post angioplasty restenosis

    Article • Pathophysiology, June 1998, Elsevier

    Dr Seppo Yla-Herttuala

  609. ADVENTITIAL GENE TRANSFER TO ARTERIAL WALL

    Article • Pharmacological Research, April 1998, Elsevier

    Dr Seppo Yla-Herttuala

  610. Expression of lipoprotein receptors in atherosclerotic lesions

    Article • Atherosclerosis, April 1998, Elsevier

    Dr Seppo Yla-Herttuala

  611. Expression of LDL Receptor, VLDL Receptor, LDL Receptor Related Protein, and Scavenger Receptor in Rabbit Atherosclerotic Lesions : Marked Induction of Scavenger Receptor and VLDL Receptor Expression During Lesion Development

    Article • Circulation, March 1998, Wolters Kluwer Health

    Dr Seppo Yla-Herttuala

  612. Expression of Extracellular SOD and iNOS in Macrophages and Smooth Muscle Cells in Human and Rabbit Atherosclerotic Lesions : Colocalization With Epitopes Characteristic of Oxidized LDL and Peroxynitrite-Modified Proteins

    Article • Arteriosclerosis Thrombosis and Vascular Biology, February 1998, Wolters Kluwer Health

    Dr Seppo Yla-Herttuala

  613. Gene Therapy for Malignant Glioma Patients

    Article • January 1998, Springer Science + Business Media

    Dr Seppo Yla-Herttuala

  614. Characterization of atherosclerotic lesions in apo E3-leiden transgenic mice

    Article • Atherosclerosis, January 1998, Elsevier

    Dr Seppo Yla-Herttuala

  615. The level of autoantibodies against oxidized LDL is not associated with the presence of coronary heart disease or diabetic kidney disease in patients with non-insulin-dependent diabetes mellitus

    Article • Free Radical Research, January 1998, Taylor & Francis

    Dr Seppo Yla-Herttuala

  616. EFFECTS OF LIPOSOME-ENCAPSULATED BISPHOSPHONATES ON ACETYLATED LDL METABOLISM, LIPID ACCUMULATION AND VIABILITY OF PHAGOCYTING CELLS

    Article • Life Sciences, December 1997, Elsevier

    Dr Seppo Yla-Herttuala

  617. VEGF Gene Transfer Reduces Intimal Thickening via Increased Production of Nitric Oxide in Carotid Arteries

    Article • Human Gene Therapy, October 1997, Mary Ann Liebert Inc

    Dr Seppo Yla-Herttuala

  618. 4.P.14 Identification of CpG island in extracellular superoxide-dismutase gene with marked hypomethylation in the arterial wall

    Article • Atherosclerosis, October 1997, Elsevier

    Dr Seppo Yla-Herttuala

  619. 4.P.301 Retrovirus-mediated scavenger receptor gene transfer leads to foam cell formation in eucaryotic cell lines

    Article • Atherosclerosis, October 1997, Elsevier

    Dr Seppo Yla-Herttuala

  620. 1.P.87 Atherosclerotic lesions in ApoE3-Leiden transgenic mice

    Article • Atherosclerosis, October 1997, Elsevier

    Dr Seppo Yla-Herttuala

  621. 1.P.120 In vivo transfer of LDL receptor gene for the treatment of familial hypercholesterolemia

    Article • Atherosclerosis, October 1997, Elsevier

    Dr Seppo Yla-Herttuala

  622. 1.P.117 Gene transfer into the carotid artery using an adventitial collar comparison of the effectiveness of different gene delivery vehicles

    Article • Atherosclerosis, October 1997, Elsevier

    Dr Seppo Yla-Herttuala

  623. 2.W12.5 Adventitial gene transfer to rabbit carotid arteries

    Article • Atherosclerosis, October 1997, Elsevier

    Dr Seppo Yla-Herttuala

  624. Gene Transfer into the Carotid Artery Using an Adventitial Collar: Comparison of the Effectiveness of the Plasmid–Liposome Complexes, Retroviruses, Pseudotyped Retroviruses, and Adenoviruses

    Article • Human Gene Therapy, September 1997, Mary Ann Liebert Inc

    Dr Seppo Yla-Herttuala

  625. β-galactosidase gene transfer to human malignant glioma

    Article • Clinical Neurology and Neurosurgery, July 1997, Elsevier

    Dr Seppo Yla-Herttuala

  626. In Vivo Low Density Lipoprotein Oxidation Relates to Coronary Reactivity in Young Men

    Article • Journal of the American College of Cardiology, July 1997, Elsevier

    Dr Seppo Yla-Herttuala

  627. Herpes simplex virus thymidine kinase gene therapy in experimental rat BT4C glioma model

    Article • Clinical Neurology and Neurosurgery, July 1997, Elsevier

    Dr Seppo Yla-Herttuala

  628. Release of replication-deficient retroviruses from a packaging cell line: Interaction with glioma tumor spheroidsin vitro

    Article • International Journal of Cancer, May 1997, Wiley

    Dr Seppo Yla-Herttuala

  629. Release of replication‐deficient retroviruses from a packaging cell line: Interaction with glioma tumor spheroids in vitro

    Article • International Journal of Cancer, May 1997, Wiley

    Dr Seppo Yla-Herttuala

  630. 5 Lipoprotein receptor gene expression in atherosclerotic lesions

    Article • Atherosclerosis, May 1997, Elsevier

    Dr Seppo Yla-Herttuala

  631. Vascular gene transfer

    Article • Current Opinion in Lipidology, April 1997, Wolters Kluwer Health

    Dr Seppo Yla-Herttuala

  632. Expression of lipoprotein receptors and related molecules in atherosclerotic lesions

    Article • Current Opinion in Lipidology, October 1996, Wolters Kluwer Health

    Dr Seppo Yla-Herttuala

  633. Autoantibodies Against Oxidized LDL Do Not Predict Atherosclerotic Vascular Disease in Non Insulin-Dependent Diabetes Mellitus

    Article • Arteriosclerosis Thrombosis and Vascular Biology, October 1996, Wolters Kluwer Health

    Dr Seppo Yla-Herttuala

  634. Pathogenesis of atherosclerosis

    Article • Maturitas, May 1996, Elsevier

    Dr Seppo Yla-Herttuala

  635. Involvement of specific macrophage-lineage cells surrounding arterioles in barrier and scavenger function in brain cortex.

    Article • Proceedings of the National Academy of Sciences, April 1996, Proceedings of the National Academy of Sciences

    Dr Seppo Yla-Herttuala

  636. Cigarette Smoking Potentiates Endothelial Dysfunction of Forearm Resistance Vessels in Patients With Hypercholesterolemia : Role of Oxidized LDL

    Article • Circulation, April 1996, Wolters Kluwer Health

    Dr Seppo Yla-Herttuala

  637. Gene Therapy for Cardiovascular Diseases

    Article • Annals of Medicine, January 1996, Taylor & Francis

    Dr Seppo Yla-Herttuala

  638. LDL OXIDATION AND ATHEROGENESIS

    Article • January 1996, Elsevier

    Dr Seppo Yla-Herttuala

  639. 484 Apolipoprotein E allelic variation and receptor interaction in Alzheimer disease

    Article • Neurobiology of Aging, January 1996, Elsevier

    Dr Seppo Yla-Herttuala

  640. 386 Dietary antioxidants are associated with good cognitive performance in finnish men: a population-based study

    Article • Neurobiology of Aging, January 1996, Elsevier

    Dr Seppo Yla-Herttuala

  641. Induction of 15-Lipoxygenase mRNA and Protein in Early Atherosclerotic Lesions

    Article • Circulation, December 1995, Wolters Kluwer Health

    Dr Seppo Yla-Herttuala

  642. Sequential acetaldehyde production, lipid peroxidation, and fibrogenesis in micropig model of alcohol-induced liver disease

    Article • Hepatology, October 1995, Wiley

    Dr Seppo Yla-Herttuala

  643. Experimental liver cirrhosis induced by alcohol and iron.

    Article • Journal of Clinical Investigation, July 1995, American Society for Clinical Investigation

    Dr Seppo Yla-Herttuala

  644. Transfer of 15-lipoxygenase gene into rabbit iliac arteries results in the appearance of oxidation-specific lipid-protein adducts characteristic of oxidized low density lipoprotein.

    Article • Journal of Clinical Investigation, June 1995, American Society for Clinical Investigation

    Dr Seppo Yla-Herttuala

  645. Oxidized LDL and atherosclerosis

    Article • Atherosclerosis, June 1995, Elsevier

    Dr Seppo Yla-Herttuala

  646. Hypoxia and platelet-derived growth factor-BB synergistically upregulate the expression of vascular endothelial growth factor in vascular smooth muscle cells

    Article • FEBS Letters, January 1995, Wiley

    Dr Seppo Yla-Herttuala

  647. Effects of bisphosphonates on the acetyl-LDL metabolism and viability of phagocyting cells

    Article • Pharmacological Research, January 1995, Elsevier

    Dr Seppo Yla-Herttuala

  648. Macrophages express inducible nitric oxide synthase mRNA in human and rabbit atherosclerotic lesions

    Article • Atherosclerosis, September 1994, Elsevier

    Dr Seppo Yla-Herttuala

  649. Regulation and expression of inducible nitric oxide synthase in vitro and in vivo

    Article • Atherosclerosis, September 1994, Elsevier

    Dr Seppo Yla-Herttuala

  650. Retrovirus-mediated transfer of 15-lipoxygenase gene into rabbit aortic smooth muscle cells in vitro

    Article • Atherosclerosis, September 1994, Elsevier

    Dr Seppo Yla-Herttuala

  651. Nitric oxide donor GEA 3162 inhibits endothelial cell-mediated oxidation of LDL

    Article • Atherosclerosis, September 1994, Elsevier

    Dr Seppo Yla-Herttuala

  652. Expression of α2-macroglobulin receptor/LDL receptor-related protein and scavenger receptor in human atherosclerotic lesions

    Article • Atherosclerosis, September 1994, Elsevier

    Dr Seppo Yla-Herttuala

  653. Expression of alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein and scavenger receptor in human atherosclerotic lesions.

    Article • Journal of Clinical Investigation, May 1994, American Society for Clinical Investigation

    Dr Seppo Yla-Herttuala

  654. Nitric oxide donor GEA 3162 inhibits endothelial cell-mediated oxidation of low density lipoprotein

    Article • FEBS Letters, January 1994, Wiley

    Dr Seppo Yla-Herttuala

  655. Rabbit and human atherosclerotic lesions contain IgG that recognizes epitopes of oxidized LDL

    Article • Arteriosclerosis Thrombosis and Vascular Biology, January 1994, Wolters Kluwer Health

    Dr Seppo Yla-Herttuala

  656. Severe hyperlipoproteinemia in congenital nephrotic syndrome of the Finnish type: effect of dialysis and kidney transplantation

    Article • Acta Paediatrica, October 1993, Wiley

    Dr Seppo Yla-Herttuala

  657. Oxidised LDL and progression of atherosclerosis

    Article • The Lancet, July 1992, Elsevier

    Dr Seppo Yla-Herttuala

  658. Autoantibody against oxidised LDL and progression of carotid atherosclerosis

    Article • The Lancet, April 1992, Elsevier

    Dr Seppo Yla-Herttuala

  659. Macrophages and smooth muscle cells express lipoprotein lipase in human and rabbit atherosclerotic lesions.

    Article • Proceedings of the National Academy of Sciences, November 1991, Proceedings of the National Academy of Sciences

    Dr Seppo Yla-Herttuala

  660. Expression of monocyte chemoattractant protein 1 in macrophage-rich areas of human and rabbit atherosclerotic lesions.

    Article • Proceedings of the National Academy of Sciences, June 1991, Proceedings of the National Academy of Sciences

    Dr Seppo Yla-Herttuala

  661. Biochemistry of the Arterial Wall in Developing Atherosclerosis

    Article • Annals of the New York Academy of Sciences, April 1991, Wiley

    Dr Seppo Yla-Herttuala

  662. Gene expression in macrophage-rich human atherosclerotic lesions. 15-lipoxygenase and acetyl low density lipoprotein receptor messenger RNA colocalize with oxidation specific lipid-protein adducts.

    Article • Journal of Clinical Investigation, April 1991, American Society for Clinical Investigation

    Dr Seppo Yla-Herttuala

  663. Macrophages and Oxidized Low Density Lipoproteins in the Pathogenesis of Atherosclerosis

    Article • Annals of Medicine, January 1991, Taylor & Francis

    Dr Seppo Yla-Herttuala

  664. Colocalization of 15-lipoxygenase mRNA and protein with epitopes of oxidized low density lipoprotein in macrophage-rich areas of atherosclerotic lesions.

    Article • Proceedings of the National Academy of Sciences, September 1990, Proceedings of the National Academy of Sciences

    Dr Seppo Yla-Herttuala

  665. Antisera and monoclonal antibodies specific for epitopes generated during oxidative modification of low density lipoprotein

    Article • Arteriosclerosis Thrombosis and Vascular Biology, May 1990, Wolters Kluwer Health

    Dr Seppo Yla-Herttuala

  666. Distribution of oxidation specific lipid-protein adducts and apolipoprotein B in atherosclerotic lesions of varying severity from WHHL rabbits

    Article • Arteriosclerosis Thrombosis and Vascular Biology, May 1990, Wolters Kluwer Health

    Dr Seppo Yla-Herttuala

  667. Biochemical composition of human internal mammary artery and saphenous vein

    Article • Journal of Vascular Surgery, March 1990, Elsevier

    Dr Seppo Yla-Herttuala

  668. Biochemical composition of human internal mammary artery and saphenous vein

    Article • Journal of Vascular Surgery, March 1990, Elsevier

    Dr Seppo Yla-Herttuala

  669. Lipoproteins in normal and atherosclerotic aorta

    Article • European Heart Journal, January 1990, European Society of Cardiology

    Dr Seppo Yla-Herttuala

  670. Intimal thickening in the coronary arteries of infants and children as an indicator of risk factors for coronary heart disease

    Article • European Heart Journal, January 1990, European Society of Cardiology

    Dr Seppo Yla-Herttuala

  671. Histological and histochemical studies on local coronary wall thickenings (cushions) in Finnish children who died violently

    Article • Apmis, January 1990, Wiley

    Dr Seppo Yla-Herttuala

  672. Evidence for the presence of oxidatively modified low density lipoprotein in atherosclerotic lesions of rabbit and man.

    Article • Journal of Clinical Investigation, October 1989, American Society for Clinical Investigation

    Dr Seppo Yla-Herttuala

  673. Macrophage foam cells from human aortic fatty streaks take up β-VLDL and acetylated LDL in primary culture

    Article • Atherosclerosis, October 1989, Elsevier

    Dr Seppo Yla-Herttuala

  674. Receptor-mediated binding and degradation of subfractions of human plasma low-density lipoprotein by cultured fibroblasts

    Article • Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, September 1989, Elsevier

    Dr Seppo Yla-Herttuala

  675. Down's syndrome and atherosclerosis

    Article • Atherosclerosis, April 1989, Elsevier

    Dr Seppo Yla-Herttuala

  676. Low density lipoprotein undergoes oxidative modification in vivo.

    Article • Proceedings of the National Academy of Sciences, February 1989, Proceedings of the National Academy of Sciences

    Dr Seppo Yla-Herttuala

  677. Stability of Plasma Total Cholesterol, Triglycerides, and Apolipoproteins B and A-I During the Early Postmortem Period

    Article • Journal of Forensic Sciences, November 1988, ASTM International

    Dr Seppo Yla-Herttuala

  678. Effect of repeated endotoxin treatment and hypercholesterolemia on preatherosclerotic lesions in weaned pigs Part 11. Lipid and glycosaminoglycan analysis of intima and inner media

    Article • Atherosclerosis, August 1988, Elsevier

    Dr Seppo Yla-Herttuala

  679. Glycosaminoglycans and apolipoproteins B and A-I in human aortas. Chemical and immunological analysis of lesion-free aortas from children and adults

    Article • Arteriosclerosis Thrombosis and Vascular Biology, July 1987, Wolters Kluwer Health

    Dr Seppo Yla-Herttuala

  680. Effect of repeated endotoxin treatment and hypercholesterolemia on preatherosclerotic lesions in weaned pigs Part 1. Scanning and transmission electron microscopic study

    Article • Atherosclerosis, May 1987, Elsevier

    Dr Seppo Yla-Herttuala

  681. Atherosclerosis and biochemical composition of coronary arteries in Finnish men Comparison of two populations with different incidences of coronary heart disease

    Article • Atherosclerosis, May 1987, Elsevier

    Dr Seppo Yla-Herttuala

  682. The effect of proteoglycans, collagen and lysyl oxidase on the metabolism of low density lipoprotein by macrophages

    Article • Atherosclerosis, October 1986, Elsevier

    Dr Seppo Yla-Herttuala

  683. Comparison of different ways of presenting the results of biochemical analyses of human coronary arteries

    Article • Atherosclerosis, July 1986, Elsevier

    Dr Seppo Yla-Herttuala

  684. Biochemical composition of coronary arteries in Finnish children

    Article • Arteriosclerosis Thrombosis and Vascular Biology, March 1986, Wolters Kluwer Health

    Dr Seppo Yla-Herttuala

  685. Enrichment of long-chain ω9 and ω6 fatty acids in arterial cholesteryl esters in the early phase of atherogenesis

    Article • Progress in Lipid Research, January 1986, Elsevier

    Dr Seppo Yla-Herttuala

  686. Effect of post-mortem time on the biochemical composition of coronary arteries

    Article • Atherosclerosis, July 1985, Elsevier

    Dr Seppo Yla-Herttuala

  687. Coronary intimal thickenings and lipids in Finnish children who died violently

    Article • Acta Paediatrica, April 1985, Wiley

    Dr Seppo Yla-Herttuala

  688. An Efficient Faint Object Spectrograph

    Article • Optica Acta International Journal of Optics, February 1982, Taylor & Francis

    Dr Seppo Yla-Herttuala

  689. Metabolism of glycosaminoglycans and lipids in smooth muscle cells from atherosclerotic rabbit aortas in culture

    Article • Atherosclerosis, November 1980, Elsevier

    Dr Seppo Yla-Herttuala

  690. Local cardiovascular gene therapy

    Article • Taylor & Francis

    PhD Mikko P Turunen, Dr Seppo Yla-Herttuala

  691. Gene Deliver y to Rabbit Arteries Using the Collar Model

    Article • Springer Science + Business Media

    PhD Mikko P Turunen, Dr Seppo Yla-Herttuala

  692. Nonviral Gene Delivery Methods in Cardiovascular Diseases

    Article • Springer Science + Business Media

    Dr Seppo Yla-Herttuala

  693. LDL Oxidation and Atherogenesis

    Article • Elsevier

    Dr Seppo Yla-Herttuala

  694. Adenoviruses as Gene Delivery Vectors

    Article • Springer Science + Business Media

    Dr Seppo Yla-Herttuala

  695. Genes Involved in Atherosclerosis and Plaque Formation

    Article • Wiley

    Dr Seppo Yla-Herttuala

  696. The Strengths and Weaknesses of VEGF Adenovirus-Driven Angiogenesis

    Article • Springer Science + Business Media

    Dr Seppo Yla-Herttuala

  697. Adenovirus-Mediated Herpes Simplex Thymidine Kinase Gene Therapy For Brain Tumors

    Article • Springer Science + Business Media

    Dr Seppo Yla-Herttuala

  698. Analysis of the adrenergic β3 receptor agonist CL316243-regulated transcriptome in the stromal vascular fraction of murine white adipose tissue (WAT)

    Article • Nuclear Receptor Signaling Atlas

    Dr Seppo Yla-Herttuala