Dr. Ernst Wagner

Contact

Email ernst.wagner@cup.uni-muenchen.de
Email

All Stories

Strategies and mechanisms for endosomal escape of therapeutic nucleic acids

Article • Current Opinion in Chemical Biology, August 2024, Elsevier

Dr. Ernst Wagner
In Vivo Endothelial Cell Gene Silencing by siRNA‐LNPs Tuned with Lipoamino Bundle Chemical and Ligand Targeting

Article • Small, June 2024, Wiley

Dr. Ernst Wagner
Lipo-Xenopeptide Polyplexes for CRISPR/Cas9 based Gene editing at ultra-low dose

Article • Journal of Controlled Release, June 2024, Elsevier

Dr. Ernst Wagner
Tumor-targeted PROTAC prodrug nanoplatform enables precise protein degradation and combination cancer therapy

Article • Acta Pharmacologica Sinica, April 2024, Springer Science + Business Media

Dr. Ernst Wagner
GalNAc- or Mannose-PEG-Functionalized Polyplexes Enable Effective Lectin-Mediated DNA Delivery

Article • Bioconjugate Chemistry, March 2024, American Chemical Society (ACS)

Dr. Ernst Wagner
Dynamic carriers for therapeutic RNA delivery

Article • Proceedings of the National Academy of Sciences, March 2024, Proceedings of the National Academy of Sciences

Dr. Ernst Wagner
Nucleic acid delivery to retinal cells using lipopeptides as a potential tool towards ocular gene therapies

Article • Journal of Colloid and Interface Science, February 2024, Elsevier

Dr. Ernst Wagner
Lipoamino bundle LNPs for efficient mRNA transfection of dendritic cells and macrophages show high spleen selectivity

Article • European Journal of Pharmaceutics and Biopharmaceutics, January 2024, Elsevier

Dr. Ernst Wagner
Transcriptional Targeting of Dendritic Cells Using an Optimized Human Fascin1 Gene Promoter

Article • International Journal of Molecular Sciences, November 2023, MDPI AG

Dr. Ernst Wagner
mCherry on Top: A Positive Read-Out Cellular Platform for Screening DMD Exon Skipping Xenopeptide–PMO Conjugates

Article • Bioconjugate Chemistry, November 2023, American Chemical Society (ACS)

Dr. Ernst Wagner
From structural design to delivery: mRNA therapeutics for cancer immunotherapy

Article • Exploration, November 2023, Wiley

Dr. Ernst Wagner
Receptor-Targeted Carbon Nanodot Delivery through Polymer Caging and Click Chemistry-Supported LRP1 Ligand Attachment

Article • Polymers, October 2023, MDPI AG

Dr. Ernst Wagner
High-resolution bioenergetics correlates the length of continuous protonatable diaminoethane motif of four-armed oligo(ethanamino)amide transfectants to cytotoxicity

Article • Journal of Controlled Release, September 2023, Elsevier

Dr. Ernst Wagner
Interleukin-6-controlled, mesenchymal stem cell-based sodium/iodide symporter gene therapy improves survival of glioblastoma-bearing mice

Article • Molecular Therapy — Oncolytics, September 2023, Elsevier

Dr. Ernst Wagner
Peptide nucleic acid-zirconium coordination nanoparticles

Article • Scientific Reports, August 2023, Springer Science + Business Media

Dr. Ernst Wagner
Chemical Evolution of Amphiphilic Xenopeptides for Potentiated Cas9 Ribonucleoprotein Delivery

Article • Journal of the American Chemical Society, July 2023, American Chemical Society (ACS)

Dr. Ernst Wagner
Iron-Gallic Acid Peptide Nanoparticles as a Versatile Platform for Cellular Delivery with Synergistic ROS Enhancement Effect

Article • Pharmaceutics, June 2023, MDPI AG

Dr. Ernst Wagner
Chemical-electron-transfer-based lipopolyplexes for enhanced siRNA delivery

Article • Cell Reports Physical Science, June 2023, Elsevier

Dr. Ernst Wagner
Molecular Chameleon Carriers for Nucleic Acid Delivery: The Sweet Spot Between Lipoplexes and Polyplexes

Article • Advanced Materials, March 2023, Wiley

Dr. Ernst Wagner
Mesenchymal Stem Cell–mediated Image-guided Sodium Iodide Symporter (NIS) Gene Therapy Improves Survival of Glioblastoma-bearing Mice

Article • Clinical Cancer Research, December 2022, American Association for Cancer Research (AACR)

Dr. Ernst Wagner
Dual EGFR- and TfR-targeted gene transfer for sodium iodide symporter gene therapy of glioblastoma

Article • Molecular Therapy — Oncolytics, December 2022, Elsevier

Dr. Ernst Wagner
Folate Receptor‐Mediated Delivery of Cas9 RNP for Enhanced Immune Checkpoint Disruption in Cancer Cells

Article • Small, November 2022, Wiley

Dr. Ernst Wagner
Combating Drug Resistance by Exploiting miRNA-200c-Controlled Phase II Detoxification

Article • Cancers, November 2022, MDPI AG

Dr. Ernst Wagner
Biomimetic Mineralization of Iron-Fumarate Nanoparticles for Protective Encapsulation and Intracellular Delivery of Proteins

Article • Chemistry of Materials, October 2022, American Chemical Society (ACS)

Dr. Ernst Wagner
A Novel Piggyback Strategy for mRNA Delivery Exploiting Adenovirus Entry Biology

Article • Viruses, September 2022, MDPI AG

Dr. Ernst Wagner
Directing the Way—Receptor and Chemical Targeting Strategies for Nucleic Acid Delivery

Article • Pharmaceutical Research, September 2022, Springer Science + Business Media

Dr. Ernst Wagner
A Novel Piggyback Strategy for mRNA Delivery Exploiting Adenovirus Entry Biology

Article • August 2022, MDPI AG

Dr. Ernst Wagner
Receptor-Targeted Dual pH-Triggered Intracellular Protein Transfer

Article • ACS Biomaterials Science & Engineering, July 2022, American Chemical Society (ACS)

Dr. Ernst Wagner
Targeting nucleic acid-based therapeutics to tumors: Challenges and strategies for polyplexes

Article • Journal of Controlled Release, June 2022, Elsevier

Dr. Ernst Wagner
Performance of nanoparticles for biomedical applications: The in vitro/in vivo discrepancy

Article • Biophysics Reviews, March 2022, American Institute of Physics

Dr. Ernst Wagner
Cross‐Linkable Polyion Complex Micelles from Polypept(o)ide‐Based ABC‐Triblock Copolymers for siRNA Delivery

Article • Macromolecular Rapid Communications, January 2022, Wiley

Dr. Ernst Wagner
Non-viral delivery of the CRISPR/Cas system: DNAversusRNAversusRNP

Article • Biomaterials Science, January 2022, Royal Society of Chemistry

Dr. Ernst Wagner
Correction to “Optimizing pDNA Lipo-polyplexes: A Balancing Act between Stability and Cargo Release”

Article • Biomacromolecules, December 2021, American Chemical Society (ACS)

Dr. Ernst Wagner
Selective sodium iodide symporter (NIS) gene therapy of glioblastoma mediated by EGFR-targeted lipopolyplexes

Article • Molecular Therapy — Oncolytics, December 2021, Elsevier

Dr. Ernst Wagner
NK Cells Armed with Chimeric Antigen Receptors (CAR): Roadblocks to Successful Development

Article • Cells, December 2021, MDPI AG

Dr. Ernst Wagner
Transferrin Receptor Targeted Polyplexes Completely Comprised of Sequence‐Defined Components

Article • Macromolecular Rapid Communications, November 2021, Wiley

Dr. Ernst Wagner
The sodium iodide symporter (NIS): novel applications for radionuclide imaging and treatment

Article • Endocrine Related Cancer, October 2021, Bioscientifica

Dr. Ernst Wagner
Gene Therapy “Made in Germany”: A Historical Perspective, Analysis of the Status Quo, and Recommendations for Action by the German Society for Gene Therapy

Article • Human Gene Therapy, October 2021, Mary Ann Liebert Inc

Dr. Ernst Wagner
Transient Permeabilization of Living Cells: Combining Shear Flow and Acoustofluidic Trapping for the Facilitated Uptake of Molecules

Article • Processes, May 2021, MDPI AG

Dr. Ernst Wagner
Optimizing pDNA Lipo-polyplexes: A Balancing Act between Stability and Cargo Release

Article • Biomacromolecules, February 2021, American Chemical Society (ACS)

Dr. Ernst Wagner
Regional Hyperthermia Enhances Mesenchymal Stem Cell Recruitment to Tumor Stroma: Implications for Mesenchymal Stem Cell-Based Tumor Therapy

Article • Molecular Therapy, February 2021, Elsevier

Dr. Ernst Wagner
Synergistic Combination of Calcium and Citrate in Mesoporous Nanoparticles Targets Pleural Tumors

Article • Chem, February 2021, Elsevier

Dr. Ernst Wagner
Carriers for Nucleic Acid Delivery to the Brain

Article • January 2021, Taylor & Francis

Dr. Ernst Wagner
Controlling Nanoparticle Formulation: A Low-Budget Prototype for the Automation of a Microfluidic Platform

Article • Processes, January 2021, MDPI AG

Dr. Ernst Wagner
Hyaluronate siRNA nanoparticles with positive charge display rapid attachment to tumor endothelium and penetration into tumors

Article • Journal of Controlled Release, January 2021, Elsevier

Dr. Ernst Wagner
Versatile, Multifunctional Block Copolymers for the Self-Assembly of Well-Defined, Nontoxic pDNA Polyplexes

Article • ACS Applied Polymer Materials, November 2020, American Chemical Society (ACS)

Dr. Ernst Wagner
A Multistage Cooperative Nanoplatform Enables Intracellular Co‐Delivery of Proteins and Chemotherapeutics for Cancer Therapy

Article • Advanced Materials, October 2020, Wiley

Dr. Ernst Wagner
Non-Viral Targeted Nucleic Acid Delivery: Apply Sequences for Optimization

Article • Pharmaceutics, September 2020, MDPI AG

Dr. Ernst Wagner
Nucleic Acid-Based Approaches for Tumor Therapy

Article • Cells, September 2020, MDPI AG

Dr. Ernst Wagner
Particle-Size-Dependent Delivery of Antitumoral miRNA Using Targeted Mesoporous Silica Nanoparticles

Article • Pharmaceutics, June 2020, MDPI AG

Dr. Ernst Wagner
Protein-drug conjugate programmed by pH-reversible linker for tumor hypoxia relief and enhanced cancer combination therapy

Article • International Journal of Pharmaceutics, May 2020, Elsevier

Dr. Ernst Wagner
Optimizing synthetic nucleic acid and protein nanocarriers: The chemical evolution approach

Article • Advanced Drug Delivery Reviews, April 2020, Elsevier

Dr. Ernst Wagner
Tuning the Morphological Appearance of Iron(III) Fumarate: Impact on Material Characteristics and Biocompatibility

Article • Chemistry of Materials, March 2020, American Chemical Society (ACS)

Christian Hirschle, Dr. Ernst Wagner
Delivery of Cas9/sgRNA Ribonucleoprotein Complexes via Hydroxystearyl Oligoamino Amides

Article • Bioconjugate Chemistry, February 2020, American Chemical Society (ACS)

Dr. Ernst Wagner
Double Click-Functionalized siRNA Polyplexes for Gene Silencing in Epidermal Growth Factor Receptor-Positive Tumor Cells

Article • ACS Biomaterials Science & Engineering, January 2020, American Chemical Society (ACS)

Dr. Ernst Wagner
Artificial peptides for antitumoral siRNA delivery

Article • Journal of Materials Chemistry B, January 2020, Royal Society of Chemistry

Dr. Ernst Wagner
Effective control of tumor growth through spatial and temporal control of theranostic sodium iodide symporter (NIS) gene expression using a heat-inducible gene promoter in engineered mesenchymal stem cells

Article • Theranostics, January 2020, Ivyspring International Publisher

Dr. Ernst Wagner
Polymer-Based Tumor-targeted Nanosystems

Article • January 2020, Springer Science + Business Media

Dr. Ernst Wagner
Inducible microRNA-200c decreases motility of breast cancer cells and reduces filamin A

Article • PLoS ONE, November 2019, PLOS

Dr. Ernst Wagner
Downregulation of GRK5 hampers the migration of breast cancer cells

Article • Scientific Reports, October 2019, Springer Science + Business Media

Dr. Ernst Wagner
A microfluidic approach for sequential assembly of siRNA polyplexes with a defined structure-activity relationship

Article • October 2019, PeerJ

Dr. Ernst Wagner
Co-delivery of pretubulysin and siEG5 to EGFR overexpressing carcinoma cells

Article • International Journal of Pharmaceutics, October 2019, Elsevier

Dr. Ernst Wagner
Core‐Shell Functionalized Zirconium‐Pemetrexed Coordination Nanoparticles as Carriers with a High Drug Content

Article • Advanced Therapeutics, September 2019, Wiley

Dr. Ernst Wagner
Polymeric Carriers for Nucleic Acid Delivery: Current Designs and Future Directions

Article • Biomacromolecules, September 2019, American Chemical Society (ACS)

Dr. Ernst Wagner
Supramolecular Assembly of Aminoethylene‐Lipopeptide PMO Conjugates into RNA Splice‐Switching Nanomicelles

Article • Advanced Functional Materials, September 2019, Wiley

Dr. Ernst Wagner
Radiation-Induced Amplification of TGFB1-Induced Mesenchymal Stem Cell–Mediated Sodium Iodide Symporter (NIS) Gene 131I Therapy

Article • Clinical Cancer Research, June 2019, American Association for Cancer Research (AACR)

Dr. Ernst Wagner
Combination Chemotherapy of L1210 Tumors in Mice with Pretubulysin and Methotrexate Lipo-Oligomer Nanoparticles

Article • Molecular Pharmaceutics, May 2019, American Chemical Society (ACS)

Dr. Ernst Wagner
A microfluidic approach for sequential assembly of siRNA polyplexes with defined structure – activity relationship

Article • April 2019, PeerJ

Dr. Ernst Wagner
A microfluidic approach for sequential assembly of siRNA polyplexes with defined structure – activity relationship

Article • April 2019, PeerJ

Dr. Ernst Wagner
IL4‐Receptor‐Targeted Dual Antitumoral Apoptotic Peptide—siRNA Conjugate Lipoplexes

Article • Advanced Functional Materials, April 2019, Wiley

Dr. Ernst Wagner
Size tunable nanoparticle formation employing droplet fusion by acoustic streaming applied to polyplexes

Article • Journal of Physics D Applied Physics, April 2019, Institute of Physics Publishing

Dr. Ernst Wagner
Targeting actin inhibits repair of doxorubicin-induced DNA damage: a novel therapeutic approach for combination therapy

Article • Cell Death and Disease, April 2019, Springer Science + Business Media

Dr. Ernst Wagner
Coordinative Binding of Polymers to Metal–Organic Framework Nanoparticles for Control of Interactions at the Biointerface

Article • ACS Nano, March 2019, American Chemical Society (ACS)

Dr. Ernst Wagner
Targeting APLN/APLNR Improves Antiangiogenic Efficiency and Blunts Proinvasive Side Effects of VEGFA/VEGFR2 Blockade in Glioblastoma

Article • Cancer Research, February 2019, American Association for Cancer Research (AACR)

Dr. Ernst Wagner
MiRNA-27a sensitizes breast cancer cells to treatment with Selective Estrogen Receptor Modulators

Article • The Breast, February 2019, Elsevier

Dr. Ernst Wagner
Dual-targeted NIS polyplexes—a theranostic strategy toward tumors with heterogeneous receptor expression

Article • Gene Therapy, January 2019, Springer Science + Business Media

Dr. Ernst Wagner
Combined antitumoral effects of pretubulysin and methotrexate

Article • Pharmacology Research & Perspectives, January 2019, Wiley

Dr. Ernst Wagner
Click-Shielded and Targeted Lipopolyplexes

Article • January 2019, Springer Science + Business Media

Dr. Ernst Wagner
Combinatorial siRNA Polyplexes for Receptor Targeting

Article • January 2019, Springer Science + Business Media

Dr. Ernst Wagner
Sequence-Defined Cationic Lipo-Oligomers Containing Unsaturated Fatty Acids for Transfection

Article • January 2019, Springer Science + Business Media

Dr. Ernst Wagner
Synthesis of Polyethylenimine-Based Nanocarriers for Systemic Tumor Targeting of Nucleic Acids

Article • January 2019, Springer Science + Business Media

Dr. Ernst Wagner
TGFB1-driven mesenchymal stem cell-mediated NIS gene transfer

Article • Endocrine Related Cancer, January 2019, Bioscientifica

Dr. Ernst Wagner
External Beam Radiation Therapy Enhances Mesenchymal Stem Cell–Mediated Sodium–Iodide Symporter Gene Delivery

Article • Human Gene Therapy, November 2018, Mary Ann Liebert Inc

Dr. Ernst Wagner
Bioresponsive polyplexes – chemically programmed for nucleic acid delivery

Article • Expert Opinion on Drug Delivery, October 2018, Taylor & Francis

Simone Hager, Dr. Ernst Wagner
Precise Enzymatic Cleavage Sites for Improved Bioactivity of siRNA Lipo-Polyplexes

Article • Bioconjugate Chemistry, September 2018, American Chemical Society (ACS)

Dr. Ernst Wagner
Folate receptor-directed orthogonal click-functionalization of siRNA lipopolyplexes for tumor cell killing in vivo

Article • Biomaterials, September 2018, Elsevier

Dr. Ernst Wagner
A proteomic analysis of chemoresistance development via sequential treatment with doxorubicin reveals novel players in MCF‑7 breast cancer cells

Article • International Journal of Molecular Medicine, July 2018, Spandidos Publications

Dr. Ernst Wagner
Epidermal growth factor receptor targeted methotrexate and small interfering RNA co-delivery

Article • The Journal of Gene Medicine, July 2018, Wiley

Dr. Ernst Wagner
Efficient Shielding of Polyplexes Using Heterotelechelic Polysarcosines

Article • Polymers, June 2018, MDPI AG

Dr. Ernst Wagner
Efficient Shielding of Polyplexes Using Heterotelechelic Polysarcosines

Article • May 2018, MDPI AG

Dr. Ernst Wagner
A proteomic analysis of an in vitro knock-out of miR-200c

Article • Scientific Reports, May 2018, Springer Science + Business Media

Dr. Ernst Wagner
In vivo tracking of adipose tissue grafts with cadmium-telluride quantum dots

Article • Archives of Plastic Surgery, March 2018, Archives of Plastic Surgery (KAMJE)

Dr. Ernst Wagner
Exploring Cytotoxic mRNAs as a Novel Class of Anti-cancer Biotherapeutics

Article • Molecular Therapy — Methods & Clinical Development, March 2018, Elsevier

Dr. Ernst Wagner
Highly Crystalline Multicolor Carbon Nanodots for Dual-Modal Imaging-Guided Photothermal Therapy of Glioma

Article • ACS Applied Materials & Interfaces, January 2018, American Chemical Society (ACS)

Dr. Ernst Wagner
Novel PAMAM-PEG-Peptide Conjugates for siRNA Delivery Targeted to the Transferrin and Epidermal Growth Factor Receptors

Article • Journal of Personalized Medicine, January 2018, MDPI AG

Dr. Ernst Wagner
Reintroducing the Sodium–Iodide Symporter to Anaplastic Thyroid Carcinoma

Article • Thyroid, December 2017, Mary Ann Liebert Inc

Dr. Ernst Wagner
Solid-phase supported design of carriers for therapeutic nucleic acid delivery

Article • Bioscience Reports, October 2017, Portland Press Ltd.

Dr. Ernst Wagner
Minicircle Versus Plasmid DNA Delivery by Receptor-Targeted Polyplexes

Article • Human Gene Therapy, October 2017, Mary Ann Liebert Inc

Dr. Ernst Wagner
Augmented glioma-targeted theranostics using multifunctional polymer-coated carbon nanodots

Article • Biomaterials, October 2017, Elsevier

Dr. Ernst Wagner
Design of Poly-l -Glutamate-Based Complexes for pDNA Delivery

Article • Macromolecular Bioscience, October 2017, Wiley

Dr. Ernst Wagner
EGFR-targeted nonviral NIS gene transfer for bioimaging and therapy of disseminated colon cancer metastases

Article • Oncotarget, September 2017, Impact Journals, LLC

Dr. Ernst Wagner
EGFR Targeting and Shielding of pDNA Lipopolyplexes via Bivalent Attachment of a Sequence-Defined PEG Agent

Article • Macromolecular Bioscience, September 2017, Wiley

Dr. Ernst Wagner
Systemic Delivery of Folate-PEG siRNA Lipopolyplexes with Enhanced Intracellular Stability forIn VivoGene Silencing in Leukemia

Article • Bioconjugate Chemistry, August 2017, American Chemical Society (ACS)

Dr. Ernst Wagner
Optimized Solid-Phase-Assisted Synthesis of Oleic Acid Containing siRNA Nanocarriers

Article • ChemMedChem, August 2017, Wiley

Dr. Ernst Wagner
Lipo-Oligomer Nanoformulations for Targeted Intracellular Protein Delivery

Article • Biomacromolecules, July 2017, American Chemical Society (ACS)

Dr. Ernst Wagner
Combining reactive triblock copolymers with functional cross-linkers: A versatile pathway to disulfide stabilized-polyplex libraries and their application as pDNA vaccines

Article • Journal of Controlled Release, July 2017, Elsevier

Dr. Ernst Wagner
Antitumoral Cascade-Targeting Ligand for IL-6 Receptor-Mediated Gene Delivery to Glioma

Article • Molecular Therapy, July 2017, Elsevier

Dr. Ernst Wagner
Nanoparticle Technology: Having Impact, but Needing Further Optimization

Article • Molecular Therapy, July 2017, Elsevier

Dr. Ernst Wagner
Polyplex Evolution: Understanding Biology, Optimizing Performance

Article • Molecular Therapy, July 2017, Elsevier

Dr. Ernst Wagner
Systemic tumor-targeted sodium iodide symporter (NIS) gene therapy of hepatocellular carcinoma mediated by B6 peptide polyplexes

Article • The Journal of Gene Medicine, May 2017, Wiley

Dr. Ernst Wagner
Influence of Defined Hydrophilic Blocks within Oligoaminoamide Copolymers: Compaction versus Shielding of pDNA Nanoparticles

Article • Polymers, April 2017, MDPI AG

Dr. Ernst Wagner
Design of Poly-l -Glutamate-Based Complexes for pDNA Delivery

Article • Macromolecular Bioscience, April 2017, Wiley

Dr. Ernst Wagner
Corrigendum to “Acid-labile pHPMA modification of four-arm oligoaminoamide pDNA polyplexes balances shielding and gene transfer activity in vitro and in vivo” [Euro. J. Pharm. Biopharm. 105 (2016) 85–96]

Article • European Journal of Pharmaceutics and Biopharmaceutics, April 2017, Elsevier

Dr. Ernst Wagner
Sequence-Defined Oligoamide Drug Conjugates of Pretubulysin and Methotrexate for Folate Receptor Targeted Cancer Therapy

Article • Macromolecular Bioscience, March 2017, Wiley

Dr. Ernst Wagner
Imaging and targeted therapy of pancreatic ductal adenocarcinoma using the theranostic sodium iodide symporter (NIS) gene

Article • Oncotarget, March 2017, Impact Journals, LLC

Dr. Ernst Wagner
Monitoring integrity and localization of modified single-stranded RNA oligonucleotides using ultrasensitive fluorescence methods

Article • PLoS ONE, March 2017, PLOS

Dr. Ernst Wagner
History of Polymeric Gene Delivery Systems

Article • Topics in Current Chemistry, February 2017, Springer Science + Business Media

Dr. Ernst Wagner
Multifunctional Nanoparticles by Coordinative Self-Assembly of His-Tagged Units with Metal–Organic Frameworks

Article • Journal of the American Chemical Society, February 2017, American Chemical Society (ACS)

Dr. Ernst Wagner
Cadmium Telluride Quantum Dots as a Fluorescence Marker for Adipose Tissue Grafts

Article • Annals of Plastic Surgery, February 2017, Wolters Kluwer Health

Dr. Ernst Wagner
Microfluidic self-assembly of folate-targeted monomolecular siRNA-lipid nanoparticles

Article • Nanoscale, January 2017, Royal Society of Chemistry

Dr. Ernst Wagner
Toward Artificial Immunotoxins: Traceless Reversible Conjugation of RNase A with Receptor Targeting and Endosomal Escape Domains

Article • Molecular Pharmaceutics, December 2016, American Chemical Society (ACS)

Dr. Ernst Wagner
Tumoral gene silencing by receptor-targeted combinatorial siRNA polyplexes

Article • Journal of Controlled Release, December 2016, Elsevier

Dr. Ernst Wagner
Intracellular Delivery of Nanobodies for Imaging of Target Proteins in Live Cells

Article • Pharmaceutical Research, October 2016, Springer Science + Business Media

Dr. Ernst Wagner
EGF receptor targeted lipo-oligocation polyplexes for antitumoral siRNA and miRNA delivery

Article • Nanotechnology, October 2016, Institute of Physics Publishing

Dr. Ernst Wagner
Controllable Acoustic Mixing of Fluids in Microchannels for the Fabrication of Therapeutic Nanoparticles

Article • Micromachines, September 2016, MDPI AG

Dr. Ernst Wagner
Call for papers: Nanoparticle Development and Applications in Cellular and Molecular Therapies

Article • Molecular Therapy, August 2016, Elsevier

Dr Seppo Yla-Herttuala, Dr. Ernst Wagner
Acid-labile pHPMA modification of four-arm oligoaminoamide pDNA polyplexes balances shielding and gene transfer activity in vitro and in vivo

Article • European Journal of Pharmaceutics and Biopharmaceutics, August 2016, Elsevier

Dr. Ernst Wagner
Sequence-defined cMET/HGFR-targeted Polymers as Gene Delivery Vehicles for the Theranostic Sodium Iodide Symporter (NIS) Gene

Article • Molecular Therapy, August 2016, Elsevier

Dr. Ernst Wagner
Hypoxia-targeted 131I therapy of hepatocellular cancer after systemic mesenchymal stem cell-mediated sodium iodide symporter gene delivery

Article • Oncotarget, July 2016, Impact Journals, LLC

Dr. Ernst Wagner
Salinomycin co-treatment enhances tamoxifen cytotoxicity in luminal A breast tumor cells by facilitating lysosomal degradation of receptor tyrosine kinases

Article • Oncotarget, July 2016, Impact Journals, LLC

Dr. Ernst Wagner
How to Tackle the Challenge of siRNA Delivery with Sequence-Defined Oligoamino Amides

Article • Macromolecular Bioscience, June 2016, Wiley

Dr. Ernst Wagner
Post-PEGylation of siRNA Lipo-oligoamino Amide Polyplexes Using Tetra-glutamylated Folic Acid as Ligand for Receptor-Targeted Delivery

Article • Molecular Pharmaceutics, May 2016, American Chemical Society (ACS)

Dr. Ernst Wagner
Ring-Shaped Microlanes and Chemical Barriers as a Platform for Probing Single-Cell Migration

Article • Scientific Reports, May 2016, Springer Science + Business Media

Dr. Ernst Wagner
Specially-Made Lipid-Based Assemblies for Improving Transmembrane Gene Delivery: Comparison of Basic Amino Acid Residue Rich Periphery

Article • Molecular Pharmaceutics, May 2016, American Chemical Society (ACS)

Dr. Ernst Wagner
Imparting Functionality to MOF Nanoparticles by External Surface Selective Covalent Attachment of Polymers

Article • Chemistry of Materials, May 2016, American Chemical Society (ACS)

Dr. Ernst Wagner
493. Nonviral Gene Transfer by Sequence-Defined Proton-Sponges with Combined Nucleic Acid Binding and Endosomal Buffering: Balancing Basicities

Article • Molecular Therapy, May 2016, Elsevier

Dr. Ernst Wagner
Targeted siRNA Delivery Using a Lipo-Oligoaminoamide Nanocore with an Influenza Peptide and Transferrin Shell

Article • Advanced Healthcare Materials, April 2016, Wiley

Dr. Ernst Wagner
Combinatorial Optimization of Sequence-Defined Oligo(ethanamino)amides for Folate Receptor-Targeted pDNA and siRNA Delivery

Article • Bioconjugate Chemistry, January 2016, American Chemical Society (ACS)

Dr. Ernst Wagner
Dual antitumoral potency of EG5 siRNA nanoplexes armed with cytotoxic bifunctional glutamyl-methotrexate targeting ligand

Article • Biomaterials, January 2016, Elsevier

Dr. Ernst Wagner
From Artificial Amino Acids to Sequence-Defined Targeted Oligoaminoamides

Article • January 2016, Springer Science + Business Media

Dr. Ernst Wagner
DNA as Tunable Adaptor for siRNA Polyplex Stabilization and Functionalization

Article • Molecular Therapy — Nucleic Acids, January 2016, Elsevier

Dr. Ernst Wagner
A Gene Gun-mediated Nonviral RNA trans-splicing Strategy for Col7a1 Repair

Article • Molecular Therapy — Nucleic Acids, January 2016, Elsevier

Dr. Ernst Wagner
Highly efficient siRNA delivery from core–shell mesoporous silica nanoparticles with multifunctional polymer caps

Article • Nanoscale, January 2016, Royal Society of Chemistry

Dr. Ernst Wagner
Precise redox-sensitive cleavage sites for improved bioactivity of siRNA lipopolyplexes

Article • Nanoscale, January 2016, Royal Society of Chemistry

Dr. Ernst Wagner
pH-Reversible Cationic RNase A Conjugates for Enhanced Cellular Delivery and Tumor Cell Killing

Article • Biomacromolecules, December 2015, American Chemical Society (ACS)

Dr. Ernst Wagner
Consecutive salinomycin treatment reduces doxorubicin resistance of breast tumor cells by diminishing drug efflux pump expression and activity

Article • Oncology Reports, December 2015, Spandidos Publications

Dr. Ernst Wagner
Fast Characterization of Polyplexes by Taylor Dispersion Analysis

Article • Macromolecules, October 2015, American Chemical Society (ACS)

Dr. Ernst Wagner
Enhanced Intracellular Protein Transduction by Sequence Defined Tetra-Oleoyl Oligoaminoamides Targeted for Cancer Therapy

Article • Advanced Functional Materials, September 2015, Wiley

Dr. Ernst Wagner
Sequence-defined nucleic acid carriers combining distinct modules for complexation, shielding, receptor-targeting and endosomal escape

Article • Journal of Controlled Release, September 2015, Elsevier

Dr. Ernst Wagner
Assessing potential peptide targeting ligands by quantification of cellular adhesion of model nanoparticles under flow conditions

Article • Journal of Controlled Release, September 2015, Elsevier

Dr. Ernst Wagner
Combination of sequence-defined oligoaminoamides with transferrin-polycation conjugates for receptor-targeted gene delivery

Article • The Journal of Gene Medicine, August 2015, Wiley

Dr. Ernst Wagner
Evaluation of improved PAMAM-G5 conjugates for gene delivery targeted to the transferrin receptor

Article • European Journal of Pharmaceutics and Biopharmaceutics, August 2015, Elsevier

Dr. Ernst Wagner
Peptide-like Polymers Exerting Effective Glioma-Targeted siRNA Delivery and Release for Therapeutic Application

Article • Small, July 2015, Wiley

Dr. Ernst Wagner
Combining polyethylenimine and Fe(III) for mediating pDNA transfection

Article • Biochimica et Biophysica Acta (BBA) - General Subjects, June 2015, Elsevier

Dr. Ernst Wagner
Twin disulfides as opportunity for improving stability and transfection efficiency of oligoaminoethane polyplexes

Article • Journal of Controlled Release, May 2015, Elsevier

Dr. Ernst Wagner
Tumor-targeted Delivery of Anti-microRNA for Cancer Therapy: pHLIP is Key

Article • Angewandte Chemie, April 2015, Wiley

Dr. Ernst Wagner
Nucleic Acid Therapeutics Using Polyplexes: A Journey of 50 Years (and Beyond)

Article • Chemical Reviews, April 2015, American Chemical Society (ACS)

Dr. Ernst Wagner
Mesenchymal Stem Cell-Mediated, Tumor Stroma-Targeted Radioiodine Therapy of Metastatic Colon Cancer Using the Sodium Iodide Symporter as Theranostic Gene

Article • Journal of Nuclear Medicine, March 2015, Society of Nuclear Medicine

Dr. Ernst Wagner
Defined Polymeric Materials for Gene Delivery

Article • Macromolecular Bioscience, February 2015, Wiley

Dr. Ernst Wagner
Dual-Targeted Polyplexes Based on Sequence-Defined Peptide-PEG-Oligoamino Amides

Article • Journal of Pharmaceutical Sciences, February 2015, Elsevier

Dr. Ernst Wagner
Histidine-rich stabilized polyplexes for cMet-directed tumor-targeted gene transfer

Article • Nanoscale, January 2015, Royal Society of Chemistry

Dr. Ernst Wagner
Multifunctional polymer-capped mesoporous silica nanoparticles for pH-responsive targeted drug delivery

Article • Nanoscale, January 2015, Royal Society of Chemistry

Dr. Ernst Wagner
Multifunctional Oligoaminoamides for the Receptor-Specific Delivery of Therapeutic RNA

Article • January 2015, Springer Science + Business Media

Dr. Ernst Wagner
Nucleic Acid Medicines: The Polymer Option

Article • January 2015, Springer Science + Business Media

Dr. Ernst Wagner
Alternation of histone and DNA methylation in human atherosclerotic carotid plaques

Article • Thrombosis and Haemostasis, January 2015, Thieme Publishing Group

Dr. Ernst Wagner
Sequence-defined polymers for the delivery of oligonucleotides

Article • Nanomedicine, December 2014, Future Medicine

Dr. Ernst Wagner
Sequential Salinomycin Treatment Results in Resistance Formation through Clonal Selection of Epithelial-Like Tumor Cells

Article • Translational Oncology, December 2014, Elsevier

Dr. Ernst Wagner
The Actin Targeting Compound Chondramide Inhibits Breast Cancer Metastasis via Reduction of Cellular Contractility

Article • PLoS ONE, November 2014, PLOS

Dr. Ernst Wagner
In vitro and in vivo characterization of the actin polymerizing compound chondramide as an angiogenic inhibitor

Article • Cardiovascular Research, September 2014, European Society of Cardiology

Dr. Ernst Wagner
Sequence-Defined Oligoaminoamides for the Delivery of siRNAs

Article • September 2014, Springer Science + Business Media

Dr. Ernst Wagner
Sequence-defined shuttles for targeted nucleic acid and protein delivery

Article • Therapeutic Delivery, September 2014, Future Science

Dr. Ernst Wagner
Bioreducible Polycations as Shuttles for Therapeutic Nucleic Acid and Protein Transfection

Article • Antioxidants & Redox Signaling, August 2014, Mary Ann Liebert Inc

Dr. Ernst Wagner
Targeting the actin cytoskeleton: selective antitumor action via trapping PKCɛ

Article • Cell Death and Disease, August 2014, Springer Science + Business Media

Dr. Ernst Wagner
Synthesis of Core–Shell Graphitic Carbon@Silica Nanospheres with Dual-Ordered Mesopores for Cancer-Targeted Photothermochemotherapy

Article • ACS Nano, July 2014, American Chemical Society (ACS)

Dr. Ernst Wagner
Stability and activity of hydroxyethyl starch-coated polyplexes in frozen solutions or lyophilizates

Article • International Journal of Pharmaceutics, July 2014, Elsevier

Dr Ahmed Besheer, Dr. Ernst Wagner
Characterization and compatibility of hydroxyethyl starch–polyethylenimine copolymers for DNA delivery

Article • Journal of Biomaterials Science Polymer Edition, May 2014, Taylor & Francis

Dr Ahmed Besheer, Dr. Ernst Wagner
Synthetic Polyglutamylation of Dual-Functional MTX Ligands for Enhanced Combined Cytotoxicity of Poly(I:C) Nanoplexes

Article • Molecular Pharmaceutics, May 2014, American Chemical Society (ACS)

Dr. Ernst Wagner
Native chemical ligation for conversion of sequence-defined oligomers into targeted pDNA and siRNA carriers

Article • Journal of Controlled Release, April 2014, Elsevier

Dr. Ernst Wagner
Comb-Like Oligoaminoethane Carriers: Change in Topology Improves pDNA Delivery

Article • Bioconjugate Chemistry, February 2014, American Chemical Society (ACS)

Dr. Ernst Wagner
Gene Regulation by Intracellular Delivery and Photodegradation of Nanoparticles Containing Small Interfering RNA

Article • Macromolecular Bioscience, February 2014, Wiley

Dr. Ernst Wagner
Retro-Inverso CendR Peptide-Mediated Polyethyleneimine for Intracranial Glioblastoma-Targeting Gene Therapy

Article • Bioconjugate Chemistry, February 2014, American Chemical Society (ACS)

Dr. Ernst Wagner
Correlation of Length of Linear Oligo(ethanamino) Amides with Gene Transfer and Cytotoxicity

Article • ChemMedChem, February 2014, Wiley

Dr. Ernst Wagner
V-ATPase Inhibition Regulates Anoikis Resistance and Metastasis of Cancer Cells

Article • Molecular Cancer Therapeutics, January 2014, American Association for Cancer Research (AACR)

Dr. Ernst Wagner
Fine-tuning of proton sponges by precise diaminoethanes and histidines in pDNA polyplexes

Article • Nanomedicine Nanotechnology Biology and Medicine, January 2014, Elsevier

Dr. Ernst Wagner
Polymers for Nucleic Acid Transfer—An Overview

Article • January 2014, Elsevier

Dr. Ernst Wagner
Pretubulysin: a new option for the treatment of metastatic cancer

Article • Cell Death and Disease, January 2014, Springer Science + Business Media

Dr. Ernst Wagner
Salinomycin treatment reduces metastatic tumor burden by hampering cancer cell migration

Article • Molecular Cancer, January 2014, Springer Science + Business Media

Dr. Ernst Wagner
Influences on Cellular Adhesion of Nanoparticles under Blood Flow-Like Conditions

Article • Biophysical Journal, January 2014, Elsevier

Dr. Ernst Wagner
Nucleic Acid Medicines: The Polymer Option

Article • January 2014, Springer Science + Business Media

Dr. Ernst Wagner
Gene Transfer with Sequence-Defined Oligo(ethanamino)amides Bioreducibly Attached to a Propylenimine Dendrimer Core

Article • Pharmaceutical Nanotechnology, December 2013, Bentham Science Publishers

Dr. Ernst Wagner
The stem cell factor SOX2 regulates the tumorigenic potential in human gastric cancer cells

Article • Carcinogenesis, December 2013, Oxford University Press (OUP)

Dr. Ernst Wagner
The proto-oncogene KRAS is targeted by miR-200c

Article • Oncotarget, November 2013, Impact Journals, LLC

Dr. Ernst Wagner
V-ATPase inhibition by archazolid leads to lysosomal dysfunction resulting in impaired cathepsin B activationin vivo

Article • International Journal of Cancer, November 2013, Wiley

Dr. Ernst Wagner
A polyphosphoester conjugate of melphalan as antitumoral agent

Article • European Journal of Pharmaceutical Sciences, November 2013, Elsevier

Dr. Ernst Wagner
Formulation development of lyophilized, long-term stable siRNA/oligoaminoamide polyplexes

Article • European Journal of Pharmaceutics and Biopharmaceutics, October 2013, Elsevier

Dr. Ernst Wagner
Glutathione-sensitive RGD-Poly(ethylene glycol)-SS-Polyethylenimine for intracranial glioblastoma targeted gene delivery

Article • The Journal of Gene Medicine, August 2013, Wiley

Dr. Ernst Wagner
Systemic Image-Guided Liver Cancer Radiovirotherapy Using Dendrimer-Coated Adenovirus Encoding the Sodium Iodide Symporter as Theranostic Gene

Article • Journal of Nuclear Medicine, July 2013, Society of Nuclear Medicine

Dr. Ernst Wagner
De-targeting by miR-143 decreases unwanted transgene expression in non-tumorigenic cells

Article • Gene Therapy, June 2013, Springer Science + Business Media

Dr. Ernst Wagner
Generation of a tumor- and tissue-specific episomal non-viral vector system

Article • BMC Biotechnology, June 2013, Springer Science + Business Media

Dr. Ernst Wagner
Comparison of four different particle sizing methods for siRNA polyplex characterization

Article • European Journal of Pharmaceutics and Biopharmaceutics, June 2013, Elsevier

Dr. Ernst Wagner
Gene silencing and antitumoral effects of Eg5 or Ran siRNA oligoaminoamide polyplexes

Article • Drug Delivery and Translational Research, April 2013, Springer Science + Business Media

Dr. Ernst Wagner
Characterization of in vivo chemoresistant human hepatocellular carcinoma cells with transendothelial differentiation capacities

Article • BMC Cancer, April 2013, Springer Science + Business Media

Dr. Ernst Wagner
The effect of molar mass and degree of hydroxyethylation on the controlled shielding and deshielding of hydroxyethyl starch-coated polyplexes

Article • Biomaterials, March 2013, Elsevier

Dr Ahmed Besheer, Dr. Ernst Wagner
Stromal Targeting of Sodium Iodide Symporter Using Mesenchymal Stem Cells Allows Enhanced Imaging and Therapy of Hepatocellular Carcinoma

Article • Human Gene Therapy, March 2013, Mary Ann Liebert Inc

Dr. Ernst Wagner
A Comprehensive Gene Expression Analysis of Resistance Formation upon Metronomic Cyclophosphamide Therapy

Article • Translational Oncology, February 2013, Elsevier

Dr. Ernst Wagner
Endothelial differentiation of adipose-derived mesenchymal stem cells is improved by epigenetic modifying drug BIX-01294

Article • European Journal of Cell Biology, February 2013, Elsevier

Dr. Ernst Wagner
Stabilizing effect of tyrosine trimers on pDNA and siRNA polyplexes

Article • Biomaterials, February 2013, Elsevier

Dr. Ernst Wagner
Systemic TNFα Gene Therapy Synergizes With Liposomal Doxorubicine in the Treatment of Metastatic Cancer

Article • Molecular Therapy, February 2013, Elsevier

Dr. Ernst Wagner
Adenoviral Vectors Coated with PAMAM Dendrimer Conjugates Allow CAR Independent Virus Uptake and Targeting to the EGF Receptor

Article • Molecular Pharmaceutics, January 2013, American Chemical Society (ACS)

Dr. Ernst Wagner
Potent Retro-Inverso d-Peptide for Simultaneous Targeting of Angiogenic Blood Vasculature and Tumor Cells

Article • Bioconjugate Chemistry, January 2013, American Chemical Society (ACS)

Dr. Ernst Wagner
Biomaterials in RNAi therapeutics: quo vadis?

Article • Biomaterials Science, January 2013, Royal Society of Chemistry

Dr. Ernst Wagner
EGFR-Targeted Adenovirus Dendrimer Coating for Improved Systemic Delivery of the Theranostic NIS Gene

Article • Molecular Therapy — Nucleic Acids, January 2013, Elsevier

Dr. Ernst Wagner
Gene Therapy for Advanced Melanoma: Selective Targeting and Therapeutic Nucleic Acids

Article • Journal of Drug Delivery, January 2013, Hindawi Publishing Corporation

Dr. Ernst Wagner
In Vivo Imaging Enables High Resolution Preclinical Trials on Patients’ Leukemia Cells Growing in Mice

Article • PLoS ONE, December 2012, PLOS

Dr. Ernst Wagner
Sequence-defined four-arm oligo(ethanamino)amides for pDNA and siRNA delivery: Impact of building blocks on efficacy

Article • Journal of Controlled Release, December 2012, Elsevier

Dr. Ernst Wagner
Stabilization of polyplexes via polymer crosslinking for efficient siRNA delivery

Article • European Journal of Pharmaceutical Sciences, December 2012, Elsevier

Dr. Ernst Wagner
miR-200c Sensitizes Breast Cancer Cells to Doxorubicin Treatment by Decreasing TrkB and Bmi1 Expression

Article • PLoS ONE, November 2012, PLOS

Dr. Ernst Wagner
Sequence Defined Disulfide-Linked Shuttle for Strongly Enhanced Intracellular Protein Delivery

Article • Molecular Pharmaceutics, November 2012, American Chemical Society (ACS)

Dr. Ernst Wagner
Anti-angiogenic effects of the tubulysin precursor pretubulysin and of simplified pretubulysin derivatives

Article • Bone Marrow Transplantation, October 2012, Wiley

Dr. Ernst Wagner
The V-ATPase-Inhibitor Archazolid Abrogates Tumor Metastasis via Inhibition of Endocytic Activation of the Rho-GTPase Rac1

Article • Cancer Research, September 2012, American Association for Cancer Research (AACR)

Dr. Ernst Wagner
Synthesis of Polyethylenimine-Based Nanocarriers for Systemic Tumor Targeting of Nucleic Acids

Article • September 2012, Springer Science + Business Media

Dr. Ernst Wagner
Therapeutic plasmid DNA versus siRNA delivery: Common and different tasks for synthetic carriers

Article • Journal of Controlled Release, July 2012, Elsevier

Dr. Ernst Wagner
Nanosized Multifunctional Polyplexes for Receptor-Mediated SiRNA Delivery

Article • ACS Nano, June 2012, American Chemical Society (ACS)

Dr. Ernst Wagner
Acid-Labile Traceless Click Linker for Protein Transduction

Article • Journal of the American Chemical Society, June 2012, American Chemical Society (ACS)

Dr. Ernst Wagner
Tuning Nanoparticle Uptake: Live-Cell Imaging Reveals Two Distinct Endocytosis Mechanisms Mediated by Natural and Artificial EGFR Targeting Ligand

Article • Nano Letters, June 2012, American Chemical Society (ACS)

Dr. Ernst Wagner
Structure–activity relationships of siRNA carriers based on sequence-defined oligo (ethane amino) amides

Article • Journal of Controlled Release, June 2012, Elsevier

Dr. Ernst Wagner
New Sequence-Defined Polyaminoamides with Tailored Endosomolytic Properties for Plasmid DNA Delivery

Article • Bioconjugate Chemistry, May 2012, American Chemical Society (ACS)

Dr. Ernst Wagner
Combinatorial treatment of mammospheres with trastuzumab and salinomycin efficiently targets HER2-positive cancer cells and cancer stem cells

Article • International Journal of Cancer, May 2012, Wiley

Dr. Ernst Wagner
Controlled shielding and deshielding of gene delivery polyplexes using hydroxyethyl starch (HES) and alpha-amylase

Article • Journal of Controlled Release, April 2012, Elsevier

Dr Ahmed Besheer, Dr. Ernst Wagner
Synthesis and characterization of new platinum(II) phosphinate complexes

Article • Journal of Coordination Chemistry, March 2012, Taylor & Francis

Dr. Ernst Wagner
PolyIC GE11 polyplex inhibits EGFR-overexpressing tumors

Article • IUBMB Life, February 2012, Wiley

Dr. Ernst Wagner
Hydrogen Bonding in α-Aminophosphonic Acids

Article • Phosphorus Sulfur and Silicon and the Related Elements, February 2012, Taylor & Francis

Dr. Ernst Wagner
Synthesis of Linear Polyethylenimine and Use in Transfection

Article • Cold Spring Harbor Protocols, February 2012, Cold Spring Harbor Laboratory Press

Dr. Ernst Wagner
Solid-phase-assisted synthesis of targeting peptide–PEG–oligo(ethane amino)amides for receptor-mediated gene delivery

Article • Organic & Biomolecular Chemistry, January 2012, Royal Society of Chemistry

Dr. Ernst Wagner
Defined Folate-PEG-siRNA Conjugates for Receptor-specific Gene Silencing

Article • Molecular Therapy — Nucleic Acids, January 2012, Elsevier

Dr. Ernst Wagner
Polymers for siRNA Delivery: Inspired by Viruses to be Targeted, Dynamic, and Precise

Article • Accounts of Chemical Research, December 2011, American Chemical Society (ACS)

Dr. Ernst Wagner
Disconnecting the Yin and Yang Relation of Epidermal Growth Factor Receptor (EGFR)-Mediated Delivery: A Fully Synthetic, EGFR-Targeted Gene Transfer System Avoiding Receptor Activation

Article • Human Gene Therapy, December 2011, Mary Ann Liebert Inc

Dr. Ernst Wagner
Image-Guided Tumor-Selective Radioiodine Therapy of Liver Cancer After Systemic Nonviral Delivery of the Sodium Iodide Symporter Gene

Article • Human Gene Therapy, December 2011, Mary Ann Liebert Inc

Dr. Ernst Wagner
Nucleic Acid-Based Therapeutics for Glioblastoma

Article • Anti-Cancer Agents in Medicinal Chemistry, October 2011, Bentham Science Publishers

Dr. Ernst Wagner
Nucleic Acid Carriers Based on Precise Polymer Conjugates

Article • Bioconjugate Chemistry, September 2011, American Chemical Society (ACS)

Dr. Ernst Wagner
Image-guided, Tumor Stroma-targeted 131I Therapy of Hepatocellular Cancer After Systemic Mesenchymal Stem Cell-mediated NIS Gene Delivery

Article • Molecular Therapy, September 2011, Elsevier

Dr. Ernst Wagner
Solid-Phase Synthesis of Sequence-Defined T-, i-, and U-Shape Polymers for pDNA and siRNA Delivery

Article • Angewandte Chemie, August 2011, Wiley

Dr. Ernst Wagner
Invading target cells: multifunctional polymer conjugates as therapeutic nucleic acid carriers

Article • Frontiers of Chemical Science and Engineering, July 2011, Springer Science + Business Media

Dr. Ernst Wagner
Sustained, high transgene expression in liver with plasmid vectors using optimized promoter-enhancer combinations

Article • The Journal of Gene Medicine, July 2011, Wiley

Dr. Ernst Wagner
To Be Targeted: Is the Magic Bullet Concept a Viable Option for Synthetic Nucleic Acid Therapeutics?

Article • Human Gene Therapy, July 2011, Mary Ann Liebert Inc

Dr. Ernst Wagner
pH-Responsive Release of Acetal-Linked Melittin from SBA-15 Mesoporous Silica

Article • Angewandte Chemie, June 2011, Wiley

Dr. Ernst Wagner
Epidermal Growth Factor–PEG Functionalized PAMAM-Pentaethylenehexamine Dendron for Targeted Gene Delivery Produced by Click Chemistry

Article • Biomacromolecules, June 2011, American Chemical Society (ACS)

Dr. Ernst Wagner
Synthesis, NMR-Spectroscopy, and Molecular Structure of a Phosphonyl Ene Diamine

Article • Zeitschrift für anorganische und allgemeine Chemie, May 2011, Wiley

Dr. Ernst Wagner
Development of a lyophilized plasmid/LPEI polyplex formulation with long-term stability—A step closer from promising technology to application

Article • Journal of Controlled Release, May 2011, Elsevier

Dr. Ernst Wagner
Dual-targeted polyplexes: One step towards a synthetic virus for cancer gene therapy

Article • Journal of Controlled Release, May 2011, Elsevier

Dr. Ernst Wagner
Epidermal Growth Factor Receptor-targeted 131I-therapy of Liver Cancer Following Systemic Delivery of the Sodium Iodide Symporter Gene

Article • Molecular Therapy, April 2011, Elsevier

Dr. Ernst Wagner
Novel Fmoc-Polyamino Acids for Solid-Phase Synthesis of Defined Polyamidoamines

Article • Organic Letters, April 2011, American Chemical Society (ACS)

Dr. Ernst Wagner
Functional modification of amide-crosslinked oligoethylenimine for improved siRNA delivery

Article • Reactive and Functional Polymers, March 2011, Elsevier

Dr. Ernst Wagner
Functional Polymer Conjugates for Medicinal Nucleic Acid Delivery

Article • January 2011, Springer Science + Business Media

Dr. Ernst Wagner
Live in vivo imaging of Egr-1 promoter activity during neonatal development, liver regeneration and wound healing

Article • BMC Developmental Biology, January 2011, Springer Science + Business Media

Dr. Ernst Wagner
Pyridylhydrazone-based PEGylation for pH-reversible lipopolyplex shielding

Article • Biomaterials, January 2011, Elsevier

Dr. Ernst Wagner
The establishment of an up-scaled micro-mixer method allows the standardized and reproducible preparation of well-defined plasmid/LPEI polyplexes

Article • European Journal of Pharmaceutics and Biopharmaceutics, January 2011, Elsevier

Dr. Ernst Wagner
EGFR-Homing dsRNA Activates Cancer-Targeted Immune Response and Eliminates Disseminated EGFR-Overexpressing Tumors in Mice

Article • Clinical Cancer Research, December 2010, American Association for Cancer Research (AACR)

Dr. Ernst Wagner
Live-cell imaging and single-particle tracking of polyplex internalization

Article • Drug Discovery Today, December 2010, Elsevier

Dr. Ernst Wagner
Impact of Indium-111 Oxine Labelling on Viability of Human Mesenchymal Stem Cells In Vitro, and 3D Cell-Tracking Using SPECT/CT In Vivo

Article • Molecular Imaging and Biology, November 2010, Springer Science + Business Media

Dr. Ernst Wagner
Multifunctional CPP Polymer System for Tumor-Targeted pDNA and siRNA Delivery

Article • October 2010, Springer Science + Business Media

Dr. Ernst Wagner
Controlled removal of a nonviral episomal vector from transfected cells

Article • Gene, October 2010, Elsevier

Dr. Ernst Wagner
Capsomer-Specific Fluorescent Labeling of Adenoviral Vector Particles Allows for Detailed Analysis of Intracellular Particle Trafficking and the Performance of Bioresponsive Bonds for Vector Capsid Modifications

Article • Human Gene Therapy, September 2010, Mary Ann Liebert Inc

Dr. Ernst Wagner
Low generation PAMAM dendrimer and CpG free plasmids allow targeted and extended transgene expression in tumors after systemic delivery

Article • Journal of Controlled Release, August 2010, Elsevier

Dr. Ernst Wagner
Poly(I:C)-Mediated Tumor Growth Suppression in EGF-Receptor Overexpressing Tumors Using EGF-Polyethylene Glycol-Linear Polyethylenimine as Carrier

Article • Pharmaceutical Research, August 2010, Springer Science + Business Media

Dr. Ernst Wagner
The impact of carboxyalkylation of branched polyethylenimine on effectiveness in small interfering RNA delivery

Article • The Journal of Gene Medicine, August 2010, Wiley

Dr. Ernst Wagner
Adenovirus-Derived Vectors for Prostate Cancer Gene Therapy

Article • Human Gene Therapy, July 2010, Mary Ann Liebert Inc

Dr. Ernst Wagner
Clinical Adenoviral Gene Therapy for Prostate Cancer

Article • Human Gene Therapy, July 2010, Mary Ann Liebert Inc

Dr. Ernst Wagner
Bioresponsive polymers for the delivery of therapeutic nucleic acids

Article • Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology, June 2010, Wiley

Dr. Ernst Wagner
In vivo chemoresistance of prostate cancer in metronomic cyclophosphamide therapy

Article • Journal of Proteomics, May 2010, Elsevier

Dr. Ernst Wagner
Tf-lipoplex-mediated c-Jun silencing improves neuronal survival following excitotoxic damage in vivo

Article • Journal of Controlled Release, March 2010, Elsevier

Dr. Ernst Wagner
Monitoring the disassembly of siRNA polyplexes in serum is crucial for predicting their biological efficacy

Article • Journal of Controlled Release, January 2010, Elsevier

Dr. Ernst Wagner
Peptide- and polymer-based delivery of therapeutic RNA

Article • Soft Matter, January 2010, Royal Society of Chemistry

Dr. Ernst Wagner
Photochemical Internalization (PCI): A Technology for Drug Delivery

Article • January 2010, Springer Science + Business Media

Pål Kristian Selbo, Dr. Ernst Wagner
Chemically Programmed Polymers for Targeted DNA and siRNA Transfection

Article • January 2010, Springer Science + Business Media

Dr. Ernst Wagner
Improvedin vivogene transfer into tumor tissue by stabilization of pseudodendritic oligoethylenimine-based polyplexes

Article • The Journal of Gene Medicine, January 2010, Wiley

Dr. Ernst Wagner
Hydrophobically Modified Oligoethylenimines as Highly Efficient Transfection Agents for siRNA Delivery

Article • Bioconjugate Chemistry, November 2009, American Chemical Society (ACS)

Dr. Ernst Wagner
Drug Nanocarriers Labeled With Near-infrared-emitting Quantum Dots (Quantoplexes): Imaging Fast Dynamics of Distribution in Living Animals

Article • Molecular Therapy, November 2009, Elsevier

Dr. Ernst Wagner
Targeted Radioiodine Therapy of Neuroblastoma Tumors following Systemic Nonviral Delivery of the Sodium Iodide Symporter Gene

Article • Clinical Cancer Research, September 2009, American Association for Cancer Research (AACR)

Dr. Ernst Wagner
Influence of the Molecular Weight of Bioreducible Oligoethylenimine Conjugates on the Polyplex Transfection Properties

Article • The AAPS Journal, June 2009, Springer Science + Business Media

Dr. Ernst Wagner
Synthesis and Biological Evaluation of a Bioresponsive and Endosomolytic siRNA−Polymer Conjugate

Article • Molecular Pharmaceutics, April 2009, American Chemical Society (ACS)

Dr. Ernst Wagner
Causal Role of Apoptosis-Inducing Factor for Neuronal Cell Death Following Traumatic Brain Injury

Article • American Journal Of Pathology, December 2008, Elsevier

MD, PhD Klas Blomgren, Dr. Ernst Wagner
Oligoethylenimine-grafted polypropylenimine dendrimers as degradable and biocompatible synthetic vectors for gene delivery

Article • Journal of Controlled Release, December 2008, Elsevier

Dr. Ernst Wagner
A microscopic view on photo-induced polyplex release from endosomes

Article • Journal of Controlled Release, December 2008, Elsevier

Dr. Ernst Wagner
Tf-lipoplexes for neuronal siRNA delivery: A promising system to mediate gene silencing in the CNS

Article • Journal of Controlled Release, December 2008, Elsevier

Dr. Ernst Wagner
Hyperthermia-Induced Targeting of Thermosensitive Gene Carriers to Tumors

Article • Human Gene Therapy, November 2008, Mary Ann Liebert Inc

Dr. Ernst Wagner
Receptor-Targeted Polyplexes for DNA and siRNA Delivery

Article • October 2008, Taylor & Francis

Dr. Ernst Wagner
Extracellular Targeting of Synthetic Therapeutic Nucleic Acid Formulations

Article • Current Gene Therapy, October 2008, Bentham Science Publishers

Dr. Ernst Wagner
Polyhydroxyethylaspartamide-spermine copolymers: Efficient vectors for gene delivery

Article • Journal of Controlled Release, October 2008, Elsevier

Dr. Ernst Wagner
Click Chemistry for High-Density Biofunctionalization of Mesoporous Silica

Article • Journal of the American Chemical Society, September 2008, American Chemical Society (ACS)

Dr. Ernst Wagner
Dynamics of photoinduced endosomal release of polyplexes

Article • Journal of Controlled Release, September 2008, Elsevier

Dr. Ernst Wagner
Nitric oxide—A novel therapeutic for cancer

Article • Nitric Oxide, September 2008, Elsevier

Dr. Ernst Wagner
An Acid Sensitive Ketal-Based Polyethylene Glycol-Oligoethylenimine Copolymer Mediates Improved Transfection Efficiency at Reduced Toxicity

Article • Pharmaceutical Research, August 2008, Springer Science + Business Media

Dr. Ernst Wagner
Hyperthermia induced targeting of thermosensitive gene carriers to tumors

Article • Human Gene Therapy, August 2008, Mary Ann Liebert Inc

Dr. Ernst Wagner
The Silent (R)evolution of Polymeric Nucleic Acid Therapeutics

Article • Pharmaceutical Research, August 2008, Springer Science + Business Media

Dr. Ernst Wagner
Acetal Linked Oligoethylenimines for Use As pH-Sensitive Gene Carriers

Article • Bioconjugate Chemistry, August 2008, American Chemical Society (ACS)

Dr. Ernst Wagner
Amine-reactive pyridylhydrazone-based PEG reagents for pH-reversible PEI polyplex shielding

Article • European Journal of Pharmaceutical Sciences, August 2008, Elsevier

Dr. Ernst Wagner
Prolonged gene silencing in hepatoma cells and primary hepatocytes after small interfering RNA delivery with biodegradable poly(β‐amino esters)

Article • The Journal of Gene Medicine, July 2008, Wiley

Dr. Ernst Wagner
Simple Modifications of Branched PEI Lead to Highly Efficient siRNA Carriers with Low Toxicity

Article • Bioconjugate Chemistry, July 2008, American Chemical Society (ACS)

Dr. Ernst Wagner
Bid-induced release of AIF from mitochondria causes immediate neuronal cell death

Article • Cell Death and Differentiation, June 2008, Springer Science + Business Media

Dr. Ernst Wagner
Gene therapy progress and prospects: synthetic polymer-based systems

Article • Gene Therapy, June 2008, Springer Science + Business Media

Dr. Ernst Wagner
Induction of Apoptosis in Murine Neuroblastoma by Systemic Delivery of Transferrin-Shielded siRNA Polyplexes for Downregulation of Ran

Article • Oligonucleotides, June 2008, Mary Ann Liebert Inc

Dr. Ernst Wagner
Breathing Life into Polycations: Functionalization with pH-Responsive Endosomolytic Peptides and Polyethylene Glycol Enables siRNA Delivery

Article • Journal of the American Chemical Society, March 2008, American Chemical Society (ACS)

Dr. Ernst Wagner
Acrolein: unwanted side product or contribution to antiangiogenic properties of metronomic cyclophosphamide therapy?

Article • Journal of Cellular and Molecular Medicine, February 2008, Wiley

Dr. Ernst Wagner
Monomolecular Assembly of siRNA and Poly(ethylene glycol)−Peptide Copolymers

Article • Biomacromolecules, February 2008, American Chemical Society (ACS)

Dr. Ernst Wagner
Converging Paths of Viral and Non-viral Vector Engineering

Article • Molecular Therapy, January 2008, Elsevier

Dr. Ernst Wagner
Photochemical Enhancement of DNA Delivery by EGF Receptor Targeted Polyplexes

Article • January 2008, Springer Science + Business Media

Dr. Ernst Wagner
Photochemical Internalization: A New Tool for Drug Delivery

Article • Current Pharmaceutical Biotechnology, December 2007, Bentham Science Publishers

Pål Kristian Selbo, Dr. Ernst Wagner
Proteomic Analysis Reveals Differences in Protein Expression in Spheroid versus Monolayer Cultures of Low-Passage Colon Carcinoma Cells

Article • Journal of Proteome Research, November 2007, American Chemical Society (ACS)

Dr. Ernst Wagner
Novel degradable oligoethylenimine acrylate ester-based pseudodendrimers for in vitro and in vivo gene transfer

Article • Gene Therapy, October 2007, Springer Science + Business Media

Dr. Ernst Wagner
Novel Biocompatible Cationic Copolymers Based on Polyaspartylhydrazide Being Potent as Gene Vector on Tumor Cells

Article • Pharmaceutical Research, October 2007, Springer Science + Business Media

Dr. Ernst Wagner
Electrophoretic purification of tumor-targeted polyethylenimine-based polyplexes reduces toxic side effects in vivo

Article • Journal of Controlled Release, October 2007, Elsevier

Dr. Ernst Wagner
Synthesis and characterization of chemically condensed oligoethylenimine containing beta-aminopropionamide linkages for siRNA delivery

Article • Biomaterials, September 2007, Elsevier

Dr. Ernst Wagner
Corrigendum to “Cellular Dynamics of EGF Receptor–targeted Synthetic Viruses”

Article • Molecular Therapy, September 2007, Elsevier

Dr. Ernst Wagner
An Acetal-Based PEGylation Reagent for pH-Sensitive Shielding of DNA Polyplexes

Article • Bioconjugate Chemistry, July 2007, American Chemical Society (ACS)

Dr. Ernst Wagner
Cellular Dynamics of EGF Receptor–Targeted Synthetic Viruses

Article • Molecular Therapy, July 2007, Elsevier

Dr. Ernst Wagner
Programmed drug delivery: nanosystems for tumor targeting

Article • Expert Opinion on Biological Therapy, May 2007, Informa Healthcare

Dr. Ernst Wagner
Delayed neuronal death after brain trauma involves p53-dependent inhibition of NF-κB transcriptional activity

Article • Cell Death and Differentiation, April 2007, Springer Science + Business Media

Dr. Ernst Wagner
Cell and Tissue Targeting of Nucleic Acids for Cancer Gene Therapy

Article • Pharmaceutical Research, March 2007, Springer Science + Business Media

Dr. Ernst Wagner
Transcriptionally Targeted Nonviral Gene Transfer Using a β-Catenin/TCF-Dependent Promoter in a Series of Different Human Low Passage Colon Cancer Cells

Article • Molecular Pharmaceutics, February 2007, American Chemical Society (ACS)

Dr. Ernst Wagner
A dimethylmaleic acid–melittin-polylysine conjugate with reduced toxicity, pH-triggered endosomolytic activity and enhanced gene transfer potential

Article • The Journal of Gene Medicine, January 2007, Wiley

Dr. Ernst Wagner
siRNA delivery by a transferrin-associated lipid-based vector: a non-viral strategy to mediate gene silencing

Article • The Journal of Gene Medicine, January 2007, Wiley

Dr. Ernst Wagner
Degradable gene carriers based on oligomerized polyamines

Article • European Journal of Pharmaceutical Sciences, December 2006, Elsevier

Dr. Ernst Wagner
Effects of Raf-1 siRNA on human cerebral microvascular endothelial cells: A potential therapeutic strategy for inhibition of tumor angiogenesis

Article • Brain Research, December 2006, Elsevier

Dr. Ernst Wagner
Optimizing targeted gene delivery: Chemical modification of viral vectors and synthesis of artificial virus vector systems

Article • The AAPS Journal, December 2006, Springer Science + Business Media

Dr. Ernst Wagner
DNA polyplexes based on degradable oligoethylenimine-derivatives: Combination with EGF receptor targeting and endosomal release functions

Article • Journal of Controlled Release, November 2006, Elsevier

Dr. Ernst Wagner
Recent Developments in the Application of Plasmid DNA-Based Vectors and Small Interfering RNA Therapeutics for Cancer

Article • Human Gene Therapy, November 2006, Mary Ann Liebert Inc

Dr. Ernst Wagner
The Internalization Route Resulting in Successful Gene Expression Depends on both Cell Line and Polyethylenimine Polyplex Type

Article • Molecular Therapy, November 2006, Elsevier

Dr. Ernst Wagner
Gene Carriers Based on Hexanediol Diacrylate Linked Oligoethylenimine: Effect of Chemical Structure of Polymer on Biological Properties

Article • Bioconjugate Chemistry, September 2006, American Chemical Society (ACS)

Dr. Ernst Wagner
pH-responsive shielding of non-viral gene vectors

Article • Expert Opinion on Drug Delivery, September 2006, Informa Healthcare

Dr. Ernst Wagner
Induction of activating transcription factor 3 by anoxia is independent of p53 and the hypoxic HIF signalling pathway

Article • Oncogene, July 2006, Springer Science + Business Media

Dr. Ernst Wagner
Melittin analogs with high lytic activity at endosomal pH enhance transfection with purified targeted PEI polyplexes

Article • Journal of Controlled Release, May 2006, Elsevier

Dr. Ernst Wagner
Temperature Dependent Gene Expression Induced by PNIPAM-Based Copolymers: Potential of Hyperthermia in Gene Transfer

Article • Bioconjugate Chemistry, May 2006, American Chemical Society (ACS)

Dr. Ernst Wagner
Effects of hypoxia and limited diffusion in tumor cell microenvironment on bystander effect of P450 prodrug therapy

Article • Cancer Gene Therapy, March 2006, Springer Science + Business Media

Dr. Ernst Wagner
Decorated Rods: A “Bottom-Up” Self-Assembly of Monomolecular DNA Complexes

Article • The Journal of Physical Chemistry B, March 2006, American Chemical Society (ACS)

Dr. Ernst Wagner
The Transport of Nanosized Gene Carriers Unraveled by Live-Cell Imaging

Article • Angewandte Chemie, February 2006, Wiley

Dr. Ernst Wagner
Optimized lipopolyplex formulations for gene transfer to human colon carcinoma cells underin vitro conditions

Article • The Journal of Gene Medicine, January 2006, Wiley

Dr. Ernst Wagner
Photochemical Internalization of Transgenes Controlled by the Heat-shock Protein 70 Promoter

Article • Photochemistry and Photobiology, January 2006, Wiley

Dr. Ernst Wagner
EGF Receptor-Targeted Synthetic Double-Stranded RNA Eliminates Glioblastoma, Breast Cancer, and Adenocarcinoma Tumors in Mice

Article • PLoS Medicine, December 2005, PLOS

Dr. Ernst Wagner
Apoptosis-Inducing Factor Triggered by Poly(ADP-Ribose) Polymerase and Bid Mediates Neuronal Cell Death after Oxygen-Glucose Deprivation and Focal Cerebral Ischemia

Article • Journal of Neuroscience, November 2005, Society for Neuroscience

MD, PhD Klas Blomgren, Dr. Ernst Wagner
Cryoconserved shielded and EGF receptor targeted DNA polyplexes: cellular mechanisms

Article • European Journal of Pharmaceutics and Biopharmaceutics, July 2005, Elsevier

Dr. Ernst Wagner
Specific Targets in Tumor Tissue for the Delivery of Therapeutic Genes

Article • Current Medicinal Chemistry - Anti-Cancer Agents, March 2005, Bentham Science Publishers

Dr. Ernst Wagner
Toward Synthetic Viruses: Endosomal pH-Triggered Deshielding of Targeted Polyplexes Greatly Enhances Gene Transfer in vitro and in vivo

Article • Molecular Therapy, March 2005, Elsevier

Dr. Ernst Wagner
Contribution of academic research to discovery and development of medicines: current status and future opportunities

Article • European Journal of Pharmaceutical Sciences, February 2005, Elsevier

Dr. Ernst Wagner
Opening of Size-Selective Pores in Endosomes during Human Rhinovirus Serotype 2 In Vivo Uncoating Monitored by Single-Organelle Flow Analysis

Article • Journal of Virology, January 2005, ASM Journals

Dr. Ernst Wagner
C- versus N-terminally linked melittin-polyethylenimine conjugates: the site of linkage strongly influences activity of DNA polyplexes

Article • The Journal of Gene Medicine, January 2005, Wiley

Dr. Ernst Wagner
Targeting of Polyplexes: Toward Synthetic Virus Vector Systems

Article • January 2005, Elsevier

Dr. Ernst Wagner
Functional Analysis of Genomic DNA, cDNA, and Nucleotide Sequence of the Mature C-Type Natriuretic Peptide Gene in Vascular Cells

Article • Arteriosclerosis Thrombosis and Vascular Biology, September 2004, Wolters Kluwer Health

Dr. Ernst Wagner
Photochemically Enhanced Gene Delivery of EGF Receptor-targeted DNA Polyplexes

Article • Journal of Drug Targeting, May 2004, Taylor & Francis

Dr. Ernst Wagner
Stabilized Nonviral Formulations for the Delivery of MCP-1 Gene into Cells of the Vasculoendothelial System

Article • Pharmaceutical Research, April 2004, Springer Science + Business Media

Dr. Ernst Wagner
Targeted nucleic acid delivery into tumors: new avenues for cancer therapy

Article • Biomedicine & Pharmacotherapy, April 2004, Elsevier

Dr. Ernst Wagner
In vitro andin vivo delivery of intact BAC DNA– comparison of different methods

Article • The Journal of Gene Medicine, February 2004, Wiley

Dr. Ernst Wagner
Purification of polyethylenimine polyplexes highlights the role of free polycations in gene transfer

Article • The Journal of Gene Medicine, January 2004, Wiley

Dr. Ernst Wagner
Strategies to Improve DNA Polyplexes for in Vivo Gene Transfer: Will “Artificial Viruses” Be the Answer?

Article • Pharmaceutical Research, January 2004, Springer Science + Business Media

Dr. Ernst Wagner
Tumor-targeted gene therapy: strategies for the preparation of ligand–polyethylene glycol–polyethylenimine/DNA complexes

Article • Journal of Controlled Release, August 2003, Elsevier

Dr. Ernst Wagner
Nanoparticles bearing polyethyleneglycol-coupled transferrin as gene carriers: preparation and in vitro evaluation

Article • International Journal of Pharmaceutics, June 2003, Elsevier

Dr. Ernst Wagner
Tissue-dependent factors affect gene delivery to tumors in vivo

Article • Gene Therapy, June 2003, Springer Science + Business Media

Dr. Ernst Wagner
Nonviral gene transfer into fetal mouse livers (a comparison between the cationic polymer PEI and naked DNA)

Article • Gene Therapy, April 2003, Springer Science + Business Media

Dr. Ernst Wagner
Optical imaging of transferrin targeted PEI/DNA complexes in living subjects

Article • Gene Therapy, April 2003, Springer Science + Business Media

Dr. Ernst Wagner
Article • BMC Biotechnology, January 2003, Springer Science + Business Media

Dr. Ernst Wagner
Novel Shielded Transferrin−Polyethylene Glycol−Polyethylenimine/DNA Complexes for Systemic Tumor-Targeted Gene Transfer

Article • Bioconjugate Chemistry, January 2003, American Chemical Society (ACS)

Dr. Ernst Wagner
Reactivation of the Mitosis-Promoting Factor in Postmitotic Cardiomyocytes

Article • Cells Tissues Organs, January 2003, Karger Publishers

Dr. Ernst Wagner
Specific systemic nonviral gene delivery to human hepatocellular carcinoma xenografts in SCID mice

Article • Hepatology, November 2002, Wiley

Dr. Ernst Wagner
Tumor-targeted gene delivery of tumor necrosis factor-α induces tumor necrosis and tumor regression without systemic toxicity

Article • Cancer Gene Therapy, July 2002, Springer Science + Business Media

Dr. Ernst Wagner
Novel colon cancer cell lines leading to better understanding of the diversity of respective primary cancers

Article • Oncogene, July 2002, Springer Science + Business Media

Dr. Ernst Wagner
Targeting tumors with non-viral gene delivery systems

Article • Drug Discovery Today, April 2002, Elsevier

Dr. Ernst Wagner
Somatic gene transfer into the lactating ovine mammary gland

Article • The Journal of Gene Medicine, March 2002, Wiley

Dr. Ernst Wagner
Article • Somatic Cell and Molecular Genetics, January 2002, Springer Science + Business Media

Dr. Ernst Wagner
Overcoming the Nuclear Barrier: Cell Cycle Independent Nonviral Gene Transfer with Linear Polyethylenimine or Electroporation

Article • Molecular Therapy, January 2002, Elsevier

Dr. Ernst Wagner
Tumor-targeted gene delivery: an attractive strategy to use highly active effector molecules in cancer treatment

Article • Gene Therapy, January 2002, Springer Science + Business Media

Dr. Ernst Wagner
Article • Somatic Cell and Molecular Genetics, January 2002, Springer Science + Business Media

Dr. Ernst Wagner
Design and gene delivery activity of modified polyethylenimines

Article • Advanced Drug Delivery Reviews, December 2001, Elsevier

Dr. Ernst Wagner
DNA/polyethylenimine transfection particles: Influence of ligands, polymer size, and PEGylation on internalization and gene expression

Article • AAPS PharmSci, September 2001, American Association of Pharmaceutical Scientists (AAPS)

Dr. Ernst Wagner
Different Strategies for Formation of PEGylated EGF-Conjugated PEI/DNA Complexes for Targeted Gene Delivery

Article • Bioconjugate Chemistry, July 2001, American Chemical Society (ACS)

Dr. Ernst Wagner
Functional maturation of dendritic cells by exposure to CD40L transgenic tumor cells, fibroblasts or keratinocytes

Article • Cancer Letters, July 2001, Elsevier

Dr. Ernst Wagner
Tumor targeting with surface-shielded ligand–polycation DNA complexes

Article • Journal of Controlled Release, May 2001, Elsevier

Dr. Ernst Wagner
Immunoadjuvant activity of interferon-γ-liposomes co-administered with influenza vaccines

Article • Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, March 2001, Elsevier

Dr. Ernst Wagner
Different behavior of branched and linear polyethylenimine for gene deliveryin vitro andin vivo

Article • The Journal of Gene Medicine, January 2001, Wiley

Dr. Ernst Wagner
Polyethylenimine/DNA complexes shielded by transferrin target gene expression to tumors after systemic application

Article • Gene Therapy, January 2001, Springer Science + Business Media

Dr. Ernst Wagner
Transfection of epithelial cells is enhanced by combined treatment with mannitol and polyethyleneglycol

Article • The Journal of Gene Medicine, January 2001, Wiley

Dr. Ernst Wagner
Xenogenization by tetanus toxoid loading into lymphoblastoid cell lines and primary human tumor cells mediated by polycations and liposomes

Article • Cancer Letters, December 2000, Elsevier

Dr. Ernst Wagner
Interleukin-2 gene-modified allogeneic melanoma cell vaccines can induce cross-protection against syngeneic tumors in mice

Article • Cancer Gene Therapy, June 2000, Springer Science + Business Media

Dr. Ernst Wagner
A versatile assay to study cellular uptake of gene transfer complexes by flow cytometry

Article • Biochimica et Biophysica Acta (BBA) - General Subjects, April 2000, Elsevier

Dr. Ernst Wagner
Efficient In Vitro Transfection of Human Keratinocytes with an Adenovirus-Enhanced Receptor-Mediated System

Article • Journal of Investigative Dermatology, April 2000, Elsevier

Dr. Ernst Wagner
Cell cycle dependence of gene transfer by lipoplex, polyplex and recombinant adenovirus

Article • Gene Therapy, February 2000, Springer Science + Business Media

Dr Matthew L Cotten, Dr. Ernst Wagner
Article • Pharmaceutical Research, January 2000, Springer Science + Business Media

Dr. Ernst Wagner
Polymer Based Systems for Tumor-Targeted Gene Delivery

Article • Nature Biotechnology, December 1999, Springer Science + Business Media

Dr. Ernst Wagner
Application of membrane-active peptides for nonviral gene delivery

Article • Advanced Drug Delivery Reviews, August 1999, Elsevier

Dr. Ernst Wagner
Membrane destabilization for improved cystolic delivery

Article • Advanced Drug Delivery Reviews, August 1999, Elsevier

Dr. Ernst Wagner
Mannose Polyethylenimine Conjugates for Targeted DNA Delivery into Dendritic Cells

Article • Journal of Biological Chemistry, July 1999, American Society for Biochemistry & Molecular Biology (ASBMB)

Dr. Ernst Wagner
Differential behaviour of lipid based and polycation based gene transfer systems in transfecting primary human fibroblasts: a potential role of polylysine in nuclear transport

Article • Biochimica et Biophysica Acta (BBA) - General Subjects, June 1999, Elsevier

Dr. Ernst Wagner
Liposomes as cytokine-supplement in tumor cell-based vaccines

Article • International Journal of Pharmaceutics, June 1999, Elsevier

Dr. Ernst Wagner
Immunotherapy of Metastatic Malignant Melanoma by a Vaccine Consisting of Autologous Interleukin 2-Transfected Cancer Cells: Outcome of a Phase I Study

Article • Human Gene Therapy, April 1999, Mary Ann Liebert Inc

Dr. Ernst Wagner
PEGylated DNA/transferrin–PEI complexes: reduced interaction with blood components, extended circulation in blood and potential for systemic gene delivery

Article • Gene Therapy, April 1999, Springer Science + Business Media

Dr. Ernst Wagner
Efficient Gene Delivery into Human Dendritic Cells by Adenovirus Polyethylenimine and Mannose Polyethylenimine Transfection

Article • Human Gene Therapy, March 1999, Mary Ann Liebert Inc

Dr Matthew L Cotten, Dr. Ernst Wagner
Polycation-based DNA complexes for tumor-targeted gene deliveryin vivo

Article • The Journal of Gene Medicine, March 1999, Wiley

Dr. Ernst Wagner
Development of Transferrin-Polycation/DNA Based Vectors for Gene Delivery to Melanoma Cells

Article • Journal of Drug Targeting, January 1999, Taylor & Francis

Dr. Ernst Wagner
Ligand—Polycation Conjugates for Receptor-Targeted Gene Transfer

Article • January 1999, Elsevier

Dr. Ernst Wagner
Application of membrane-active peptides for drug and gene delivery across cellular membranes

Article • Advanced Drug Delivery Reviews, October 1998, Elsevier

Dr. Ernst Wagner
The size of DNA/transferrin-PEI complexes is an important factor for gene expression in cultured cells

Article • Gene Therapy, October 1998, Springer Science + Business Media

Dr. Ernst Wagner
Influence of the DNA complexation medium on the transfection efficiency of lipospermine/DNA particles

Article • Gene Therapy, June 1998, Springer Science + Business Media

Dr. Ernst Wagner
An RGD–Oligolysine Peptide: A Prototype Construct for Integrin-Mediated Gene Delivery

Article • Human Gene Therapy, May 1998, Mary Ann Liebert Inc

Dr. Ernst Wagner
Effects of membrane-active agents in gene delivery

Article • Journal of Controlled Release, April 1998, Elsevier

Dr. Ernst Wagner
Polylysine-based transfection systems utilizing receptor-mediated delivery

Article • Advanced Drug Delivery Reviews, March 1998, Elsevier

Dr. Ernst Wagner
Increase of proliferation rate and enhancement of antitumor cytotoxicity of expanded human CD3+CD56+ immunologic effector cells by receptor-mediated transfection with the interleukin-7 gene

Article • Gene Therapy, January 1998, Springer Science + Business Media

Dr. Ernst Wagner
Gene-Modified Dendritic Cells by Receptor-Mediated Transfection

Article • January 1998, Springer Science + Business Media

Dr. Ernst Wagner
Stabilization of gene delivery systems by freeze-drying

Article • International Journal of Pharmaceutics, November 1997, Elsevier

Dr. Ernst Wagner
Coupling of cell-binding ligands to polyethylenimine for targeted gene delivery

Article • Gene Therapy, May 1997, Springer Science + Business Media

Dr. Ernst Wagner
Phase I study to the immunotherapy of metastatic malignant melanoma by a cancer vaccine consisting of autologous cancer cells transfected with the human IL-2 gene

Article • Journal of Molecular Medicine, April 1997, Springer Science + Business Media

Dr. Ernst Wagner
Glycerol and Polylysine Synergize in Their Ability to Rupture Vesicular Membranes: A Mechanism for Increased Transferrin–Polylysine-Mediated Gene Transfer1

Article • Experimental Cell Research, April 1997, Elsevier

Dr. Ernst Wagner
Lymphocyte apoptosis: induction by gene transfer techniques

Article • Gene Therapy, April 1997, Springer Science + Business Media

Dr. Ernst Wagner
Nomenclature for Synthetic Gene Delivery Systems

Article • Human Gene Therapy, March 1997, Mary Ann Liebert Inc

Dr. Ernst Wagner
Influence of Membrane-Active Peptides on Lipospermine/DNA Complex Mediated Gene Transfer

Article • Bioconjugate Chemistry, March 1997, American Chemical Society (ACS)

Dr. Ernst Wagner
The cdc2Ms Kinase Is Differently Regulated in the Cytoplasm and in the Nucleus

Article • PLANT PHYSIOLOGY, March 1997, American Society of Plant Biologists (ASPB)

Dr. Ernst Wagner
In vitro targeting and specific transfection of human neuroblastoma cells by chCE7 antibody-mediated gene transfer

Article • Gene Therapy, February 1997, Springer Science + Business Media

Dr. Ernst Wagner
Functional Re-expression of Laminin-5 in Laminin-γ2-deficient Human Keratinocytes Modifies Cell Morphology, Motility, and Adhesion

Article • Journal of Biological Chemistry, August 1996, American Society for Biochemistry & Molecular Biology (ASBMB)

Dr. Ernst Wagner
Activation of the Complement System by Synthetic DNA Complexes: A Potential Barrier for Intravenous Gene Delivery

Article • Human Gene Therapy, August 1996, Mary Ann Liebert Inc

Dr. Ernst Wagner
Extrachromosomal recombination occurs efficiently in cells defective in various DNA repair systems

Article • Nucleic Acids Research, June 1996, Oxford University Press (OUP)

Dr. Ernst Wagner
Glycerol Enhancement of Ligand-Polylysine/DNA Transfection

Article • BioTechniques, May 1996, Future Science

Dr. Ernst Wagner
Developmental and Cell Cycle Regulation of Alfalfa nucMs1, a Plant Homolog of the Yeast Nsr1 and Mammalian Nucleolin

Article • The Plant Cell, March 1996, JSTOR

Dr. Ernst Wagner
Phase I Study to the Immunotherapy of Metastatic Malignant Melanoma by a Cancer Vaccine Consisting of Autologous Cancer Cells Transfected with the Human IL-2 Gene. University of Vienna, Austria

Article • Human Gene Therapy, March 1996, Mary Ann Liebert Inc

Dr. Ernst Wagner
Developmental and cell cycle regulation of alfalfa nucMs1, a plant homolog of the yeast Nsr1 and mammalian nucleolin.

Article • The Plant Cell, March 1996, American Society of Plant Biologists (ASPB)

Dr. Ernst Wagner
Virus-mediated release of endosomal content in vitro: different behavior of adenovirus and rhinovirus serotype 2

Article • Journal of Cell Biology, October 1995, Rockefeller University Press

Dr. Ernst Wagner
Receptor-Mediated Gene Transfer into Human T Lymphocytes via Binding of DNA/CD3 Antibody Particles to the CD3 T Cell Receptor Complex

Article • Human Gene Therapy, June 1995, Mary Ann Liebert Inc

Dr. Ernst Wagner
Regulation of the Tissue Factor Promoter in Endothelial Cells

Article • Journal of Biological Chemistry, February 1995, American Society for Biochemistry & Molecular Biology (ASBMB)

Dr. Ernst Wagner
Rhinovirus-mediated endosomal release of transfection complexes.

Article • Journal of Virology, January 1995, ASM Journals

Dr. Ernst Wagner
Psoralen Treatment of Adenovirus Particles Eliminates Virus Replication and Transcription While Maintaining the Endosomolytic Activity of the Virus Capsid

Article • Virology, November 1994, Elsevier

Dr. Ernst Wagner
High-Level Expression of Various Apolipoprotein (a) Isoforms by "Transferrinfection": The Role of Kringle IV Sequences in the Extracellular Association with Low-Density Lipoprotein

Article • Biochemistry, October 1994, American Chemical Society (ACS)

Dr. Ernst Wagner
Synthesis and anti-HIV activity of thiocholesteryl-coupled phosphodiester antisense oligonucleotides incorporated into immunoliposomes

Article • Antiviral Research, September 1994, Elsevier

Dr. Ernst Wagner
In vivo production of human factor VII in mice after intrasplenic implantation of primary fibroblasts transfected by receptor-mediated, adenovirus-augmented gene delivery.

Article • Proceedings of the National Academy of Sciences, May 1994, Proceedings of the National Academy of Sciences

Dr Matthew L Cotten, Dr. Ernst Wagner
Chirale Lactole, XI. Eine Methode zur Bestimmung der Absolutkonfiguration chiraler Alkanole

Article • European Journal of Inorganic Chemistry, May 1994, Wiley

Dr. Ernst Wagner
Delivery of drugs, proteins and genes into cells using transferrin as a ligand for receptor-mediated endocytosis

Article • Advanced Drug Delivery Reviews, April 1994, Elsevier

Dr. Ernst Wagner
Efficient Foreign Gene Expression in Epstein-Barr Virus-Transformed Human B-Cells

Article • Virology, February 1994, Elsevier

Dr Matthew L Cotten, Dr. Ernst Wagner
Carbohydrate receptor-mediated gene transfer to human T leukaemic cells

Article • Glycobiology, January 1994, Oxford University Press (OUP)

Dr. Ernst Wagner
Gene Therapy for B-cell Lymphoma in a SCID Mouse Model using an Immunoglobulin-Regulated Diphtheria Toxin Gene Delivered by a Novel Adenovirus-Polylysine Conjugate

Article • Cancer Biotherapy, January 1994, Mary Ann Liebert Inc

Dr. Ernst Wagner
Somatic gene therapy for cancer: the utility of transferrinfection in generating ‘tumor vaccines’

Article • Gene, December 1993, Elsevier

Dr Matthew L Cotten, Dr. Ernst Wagner
Non-viral approaches to gene therapy

Article • Current Opinion in Biotechnology, December 1993, Elsevier

Dr. Ernst Wagner
Receptor-mediated Gene Transfer to Airway Epithelial Cells in Primary Culture

Article • American Journal of Respiratory Cell and Molecular Biology, October 1993, American Thoracic Society

Dr. Ernst Wagner
Direct In Vivo Gene Transfer to Airway Epithelium Employing Adenovirus–Polylysine–DNA Complexes

Article • Human Gene Therapy, February 1993, Mary Ann Liebert Inc

Dr Matthew L Cotten, Dr. Ernst Wagner
[42] Receptor-mediated transport of DNA into eukaryotic cells

Article • January 1993, Elsevier

Dr Matthew L Cotten, Dr. Ernst Wagner
Chicken adenovirus (CELO virus) particles augment receptor-mediated DNA delivery to mammalian cells and yield exceptional levels of stable transformants.

Article • Journal of Virology, January 1993, ASM Journals

Dr. Ernst Wagner
Gene transfer into hepatocytes using asialoglycoprotein receptor mediated endocytosis of DNA complexed with an artificial tetra-antennary galactose ligand

Article • Bioconjugate Chemistry, November 1992, American Chemical Society (ACS)

Dr. Ernst Wagner
Transferrinfection: A Highly Efficient Way to Express Gene Constructs in Eukaryotic Cells

Article • Annals of the New York Academy of Sciences, October 1992, Wiley

Dr. Ernst Wagner
Influenza virus hemagglutinin HA-2 N-terminal fusogenic peptides augment gene transfer by transferrin-polylysine-DNA complexes: toward a synthetic virus-like gene-transfer vehicle.

Article • Proceedings of the National Academy of Sciences, September 1992, Proceedings of the National Academy of Sciences

Dr Matthew L Cotten, Dr. Ernst Wagner
High-efficiency receptor-mediated delivery of small and large (48 kilobase gene constructs using the endosome-disruption activity of defective or chemically inactivated adenovirus particles.

Article • Proceedings of the National Academy of Sciences, July 1992, Proceedings of the National Academy of Sciences

Dr Matthew L Cotten, Dr. Ernst Wagner
Coupling of adenovirus to transferrin-polylysine/DNA complexes greatly enhances receptor-mediated gene delivery and expression of transfected genes.

Article • Proceedings of the National Academy of Sciences, July 1992, Proceedings of the National Academy of Sciences

Dr Matthew L Cotten, Dr. Ernst Wagner
High-Efficiency Gene Transfer Mediated by Adenovirus Coupled to DNA–Polylysine Complexes

Article • Human Gene Therapy, April 1992, Mary Ann Liebert Inc

Dr Matthew L Cotten, Dr. Ernst Wagner
Gene Transfer to Respiratory Epithelial Cells via the Receptor-mediated Endocytosis Pathway

Article • American Journal of Respiratory Cell and Molecular Biology, March 1992, American Thoracic Society

Dr. Ernst Wagner
Effective incorporation of 2'-O-methyl-oligoribonuclectides into liposomes and enhanced cell association through modification with thiocholesterol

Article • Nucleic Acids Research, January 1992, Oxford University Press (OUP)

Dr. Ernst Wagner
Adenovirus enhancement of transferrin-polylysine-mediated gene delivery.

Article • Proceedings of the National Academy of Sciences, October 1991, Proceedings of the National Academy of Sciences

Dr Matthew L Cotten, Dr. Ernst Wagner
DNA-binding transferrin conjugates as functional gene-delivery agents: synthesis by linkage of polylysine or ethidium homodimer to the transferrin carbohydrate moiety

Article • Bioconjugate Chemistry, July 1991, American Chemical Society (ACS)

Dr. Ernst Wagner
2'-O-methyl, 2'-O-ethyl oligoribonucleotides and phosphorothioate oligodeoxyribonucleotides as inhibitors of the in vitro U7 snRNP-dependent mRNA processing event

Article • Nucleic Acids Research, May 1991, Oxford University Press (OUP)

Dr. Ernst Wagner
Transferrin-polycation-DNA complexes: the effect of polycations on the structure of the complex and DNA delivery to cells.

Article • Proceedings of the National Academy of Sciences, May 1991, Proceedings of the National Academy of Sciences

Dr. Ernst Wagner
Pheromone, 3.Mitt.: Eine einfache Methode zur Steuerung der Reduktion von ?-Alkoxy-carbonylverbindungen

Article • Monatshefte für Chemie - Chemical Monthly, April 1991, Springer Science + Business Media

Dr. Ernst Wagner
A simple procedure for the preparation of protected 2′-O-methyl or 2′-O-ethyl ribonucleoside-3′-O-phosphoramidites

Article • Nucleic Acids Research, January 1991, Oxford University Press (OUP)

Dr Matthew L Cotten, Dr. Ernst Wagner
Chemie von a-Aminonitrilen. Aldomerisierung von Glycolaldehyd-phosphat zu racemischen Hexose-2,4,6-triphosphaten und (in Gegenwart von Formaldehyd) racemischen Pentose-2,4-diphosphaten: rac-Allose-2,4,6-triphosphat und rac-Ribose-2,4-diphosphat sind die R

Article • Helvetica Chimica Acta, August 1990, Wiley

Dr. Ernst Wagner
Chemie von α-Aminonitrilen. Aziridin-2-carbonitril, ein Vorläufer von rca-O3-Phosphoserinnitril und Glycolaldehyd-phosphat

Article • Helvetica Chimica Acta, August 1990, Wiley

Dr. Ernst Wagner
Transferrin-polycation-mediated introduction of DNA into human leukemic cells: stimulation by agents that affect the survival of transfected DNA or modulate transferrin receptor levels.

Article • Proceedings of the National Academy of Sciences, June 1990, Proceedings of the National Academy of Sciences

Dr. Ernst Wagner
Receptor-mediated endocytosis of transferrin-polycation conjugates: an efficient way to introduce DNA into hematopoietic cells.

Article • Proceedings of the National Academy of Sciences, May 1990, Proceedings of the National Academy of Sciences

Dr. Ernst Wagner
Transferrin-polycation conjugates as carriers for DNA uptake into cells.

Article • Proceedings of the National Academy of Sciences, May 1990, Proceedings of the National Academy of Sciences

Dr. Ernst Wagner
Ein einfaches Verfahren zur Herstellung anellierter Thiophene

Article • Monatshefte für Chemie - Chemical Monthly, May 1986, Springer Science + Business Media

Dr. Ernst Wagner
Chirale Lactole, VI. Eine Methode zur Bestimmung der Absolutkonfiguration chiraler α-hydroxysubstituierter Nitrile, Alkine und Aldehyde

Article • European Journal of Inorganic Chemistry, February 1986, Wiley

Dr. Ernst Wagner
Kohlenhydrat-Modelle, I. Kinetische und thermodynamische Effekte bei Acetalisierungsreaktionen enantiomerenreiner Thiolactole

Article • European Journal of Inorganic Chemistry, August 1985, Wiley

Dr. Ernst Wagner
Chirale Lactole, IV. Selektivitäten bei Acetalisierungsreaktionen enantiomerenreiner Lactole am Beispiel von Octahydro-8,9,9-trimethyl-5,8-methano-2H-1-benzopyran-2-ol

Article • European Journal of Inorganic Chemistry, May 1985, Wiley

Dr. Ernst Wagner
Gene Delivery Using Polymer Therapeutics

Article • Springer Science + Business Media

Dr. Ernst Wagner
Nonviral Vector Systems for Cancer Gene Therapy

Article • Springer Science + Business Media

Dr. Ernst Wagner
Optimizing Polyplexes into Synthetic Viruses for Tumor-Targeted Gene Therapy

Article • Springer Science + Business Media

Dr. Ernst Wagner
In Vitro Gene Transfection with Surface-Modified Gelatin Nanoparticles

Article • Institute of Electrical & Electronics Engineers (IEEE)

Dr. Ernst Wagner
Article • PLOS

Dr. Ernst Wagner

Search

Main menu

Discover

Subjects on Kudos

Services and resources

Admin

Contact

All Stories

Contact

Social

All Stories