All Stories

  1. Development of the ULK1-Recruiting Chimeras (ULKRECs) to enable proximity-induced and ULK1-dependent degradation of mitochondria

    Article • April 2024, Cold Spring Harbor Laboratory Press

    David Selwood

  2. Neuroprotection in an Experimental Model of Multiple Sclerosis via Opening of Big Conductance, Calcium-Activated Potassium Channels

    Article • Pharmaceuticals, July 2023, MDPI AG

    David Selwood

  3. Synthetic PROTACs based on a depsipeptide macrocycle selectively degrade cyclophilin A and inhibit HIV-1

    Article • March 2023, Research Square

    David Selwood

  4. Therapeutic Validation of GEF-H1 Using a De Novo Designed Inhibitor in Models of Retinal Disease

    Article • Cells, May 2022, MDPI AG

    David Selwood

  5. Studies on the function of myeloid‐derived Neuropilin‐1 in glioma: a focus on tumor hypoxia

    Article • The FASEB Journal, May 2022, Wiley

    David Selwood

  6. A Series of Substituted Bis-Aminotriazines Are Activators of the Natriuretic Peptide Receptor C

    Article • Journal of Medicinal Chemistry, March 2022, American Chemical Society (ACS)

    David Selwood

  7. VEGFA, B, C: Implications of the C-Terminal Sequence Variations for the Interaction with Neuropilins

    Article • Biomolecules, February 2022, MDPI AG

    David Selwood

  8. VSN16S, an agonist of the cannabinoid receptor, reduces IOP profiles and exhibits neuroprotective properties in a rat model of glaucoma

    Article • Acta Ophthalmologica, January 2022, Wiley

    David Selwood

  9. Cannabidiol activates PINK1-Parkin-dependent mitophagy and mitochondrial-derived vesicles

    Article • European Journal of Cell Biology, January 2022, Elsevier

    David Selwood

  10. Oligodendrocytes, BK channels and the preservation of myelin

    Article • F1000Research, November 2021, Faculty of 1000, Ltd.

    David Selwood

  11. Oligodendrocytes, BK channels and remyelination

    Article • F1000Research, August 2021, Faculty of 1000, Ltd.

    David Selwood

  12. Reversal of behavioural phenotype by the cannabinoid-like compound VSN16R in fragile X syndrome mice

    Article • Brain, July 2021, Oxford University Press (OUP)

    David Selwood

  13. Hepatitis C virus exploits cyclophilin A to evade PKR

    Article • eLife, June 2020, eLife

    David Selwood

  14. The β4-Subunit of the Large-Conductance Potassium Ion Channel KCa1.1 Regulates Outflow Facility in Mice

    Article • Investigative Ophthalmology & Visual Science, March 2020, Association for Research in Vision and Ophthalmology (ARVO)

    David Selwood

  15. A new patient‐derived iPSC model for dystroglycanopathies validates a compound that increases glycosylation of α‐dystroglycan

    Article • EMBO Reports, September 2019, Springer Science + Business Media

    David Selwood

  16. The Cannabinoid-Like Compound, VSN16R, Acts on Large Conductance, Ca2+-Activated K+ Channels to Modulate Hippocampal CA1 Pyramidal Neuron Firing

    Article • Pharmaceuticals, July 2019, MDPI AG

    David Selwood

  17. N10‐carbonyl‐substituted phenothiazines inhibiting lipid peroxidation and associated nitric oxide consumption powerfully protect brain tissue against oxidative stress

    Article • Chemical Biology & Drug Design, June 2019, Wiley

    David Selwood

  18. Commentary: Reproducible science, why protocols matter

    Article • Chemical Biology & Drug Design, June 2019, Wiley

    David Selwood

  19. Emerging small-molecule treatments for multiple sclerosis: focus on B cells

    Article • F1000Research, March 2019, Faculty of 1000, Ltd.

    David Selwood

  20. Mitochondrial Permeability Transition: A Molecular Lesion with Multiple Drug Targets

    Article • Trends in Pharmacological Sciences, January 2019, Elsevier

    David Selwood

  21. Identification of Kinases and Phosphatases That Regulate ATG4B Activity by siRNA and Small Molecule Screening in Cells

    Article • Frontiers in Cell and Developmental Biology, November 2018, Frontiers

    Dr Janos KristonVizi, David Selwood

  22. Biophysical screening methods for extracellular domain peptide receptors, application to natriuretic peptide receptor C ligands

    Article • Chemical Biology & Drug Design, October 2018, Wiley

    David Selwood

  23. Structure and function ofL-threonine-3-dehydrogenase from the parasitic protozoanTrypanosoma bruceirevealed by X-ray crystallography and geometric simulations

    Article • Acta Crystallographica Section D Structural Biology, September 2018, International Union of Crystallography

    David Selwood

  24. Small Molecule Neuropilin-1 Antagonists Combine Antiangiogenic and Antitumor Activity with Immune Modulation through Reduction of Transforming Growth Factor Beta (TGFβ) Production in Regulatory T-Cells

    Article • Journal of Medicinal Chemistry, April 2018, American Chemical Society (ACS)

    David Selwood

  25. Architecture and hydration of the arginine‐binding site of neuropilin‐1

    Article • FEBS Journal, February 2018, Wiley

    David Selwood

  26. IKKγ-Mimetic Peptides Block the Resistance to Apoptosis Associated with Kaposi's Sarcoma-Associated Herpesvirus Infection

    Article • Journal of Virology, September 2017, ASM Journals

    Tracey Barrett, David Selwood

  27. Big conductance calcium-activated potassium channel openers control spasticity without sedation

    Article • British Journal of Pharmacology, July 2017, Wiley

    Dr Alexander I Bondarenko, David Selwood

  28. Abstract 4919: Ablation of neuropilin 1 from glioma-associated microglia and macrophages slows tumor progression

    Article • Cancer Research, July 2017, American Association for Cancer Research (AACR)

    David Selwood

  29. Improved fluorescence assays to measure the defects associated with F508del-CFTR allow identification of new active compounds

    Article • British Journal of Pharmacology, February 2017, Wiley

    Dr Paola Vergani, Dr Emily Langron, David Selwood

  30. Is multiple sclerosis a length-dependent central axonopathy? The case for therapeutic lag and the asynchronous progressive MS hypotheses

    Article • Multiple Sclerosis and Related Disorders, February 2017, Elsevier

    David Selwood

  31. Macrocycles, the edge of drug‐likeness chemical space or Goldilocks zone?

    Article • Chemical Biology & Drug Design, February 2017, Wiley

    David Selwood

  32. VSN16R – A NOVEL TREATMENT FOR SPASTICITY IN EXPERIMENTAL MULTIPLE SCLEROSIS

    Article • Journal of Neurology Neurosurgery & Psychiatry, November 2016, BMJ

    David Selwood

  33. Abstract A129: Ablation of neuropilin 1 from glioma associated macrophages and microglia slows tumor progression

    Article • Cancer Immunology Research, October 2016, American Association for Cancer Research (AACR)

    David Selwood

  34. Nonhuman TRIM5 Variants Enhance Recognition of HIV-1-Infected Cells by CD8 + T Cells

    Article • Journal of Virology, October 2016, ASM Journals

    David Selwood

  35. Infection Counter: Automated Quantification of in Vitro Virus Replication by Fluorescence Microscopy

    Article • Viruses, July 2016, MDPI AG

    David Selwood

  36. Characterisation of Transcriptional Changes in the Spinal Cord of the Progressive Experimental Autoimmune Encephalomyelitis Biozzi ABH Mouse Model by RNA Sequencing

    Article • PLoS ONE, June 2016, PLOS

    David Selwood

  37. HIV-1 capsid is involved in post-nuclear entry steps

    Article • Retrovirology, April 2016, Springer Science + Business Media

    David Selwood

  38. Selective Inhibition of the Mitochondrial Permeability Transition Pore Protects against Neurodegeneration in Experimental Multiple Sclerosis

    Article • Journal of Biological Chemistry, February 2016, Elsevier

    David Selwood

  39. Ablation of Neuropilin 1 from glioma-associated microglia and macrophages slows tumor progression

    Article • Oncotarget, January 2016, Impact Journals, LLC

    David Selwood

  40. A new small molecule inhibitor of soluble guanylate cyclase

    Article • Bioorganic & Medicinal Chemistry, September 2015, Elsevier

    David Selwood

  41. Phosphoinositide Modulation of Heteromeric Kv1 Channels Adjusts Output of Spiral Ganglion Neurons from Hearing Mice

    Article • Journal of Neuroscience, August 2015, Society for Neuroscience

    David Selwood

  42. Correction to Imidazol-1-ylethylindazole Voltage-Gated Sodium Channel Ligands Are Neuroprotective during Optic Neuritis in a Mouse Model of Multiple Sclerosis

    Article • Journal of Medicinal Chemistry, April 2015, American Chemical Society (ACS)

    David Selwood

  43. Neuroprotection in Experimental Autoimmune Encephalomyelitis and Progressive Multiple Sclerosis by Cannabis-Based Cannabinoids

    Article • Journal of Neuroimmune Pharmacology, December 2014, Springer Science + Business Media

    David Selwood

  44. Small Steps to New Drugs for Bugs

    Article • Chemical Biology & Drug Design, December 2014, Wiley

    David Selwood

  45. 2- and 3-substituted imidazo[1,2-a]pyrazines as inhibitors of bacterial type IV secretion

    Article • Bioorganic & Medicinal Chemistry, November 2014, Elsevier

    David Selwood

  46. Endothelial C-type natriuretic peptide maintains vascular homeostasis

    Article • Journal of Clinical Investigation, August 2014, American Society for Clinical Investigation

    David Selwood

  47. A Bifurcated Proteoglycan Binding Small Molecule Carrier for siRNA Delivery

    Article • Chemical Biology & Drug Design, May 2014, Wiley

    David Selwood

  48. N‐Terminal Modification of VEGF‐A C Terminus‐Derived Peptides Delineates Structural Features Involved in Neuropilin‐1 Binding and Functional Activity

    Article • ChemBioChem, April 2014, Wiley

    David Selwood

  49. Imidazol-1-ylethylindazole Voltage-Gated Sodium Channel Ligands Are Neuroprotective during Optic Neuritis in a Mouse Model of Multiple Sclerosis

    Article • Journal of Medicinal Chemistry, March 2014, American Chemical Society (ACS)

    David Selwood

  50. Two‐ and Three‐dimensional Rings in Drugs

    Article • Chemical Biology & Drug Design, March 2014, Wiley

    David Selwood

  51. Surface plasmon resonance using the catalytic domain of soluble guanylate cyclase allows the detection of enzyme activators

    Article • Bioorganic & Medicinal Chemistry Letters, February 2014, Elsevier

    David Selwood

  52. Suppression of type 1 pilus assembly in uropathogenic Escherichia coli by chemical inhibition of subunit polymerization

    Article • Journal of Antimicrobial Chemotherapy, December 2013, Oxford University Press (OUP)

    David Selwood

  53. Lesional-targeting of neuroprotection to the inflammatory penumbra in experimental multiple sclerosis

    Article • Brain, November 2013, Oxford University Press (OUP)

    David Selwood

  54. HIV-1 evades innate immune recognition through specific cofactor recruitment

    Article • Nature, November 2013, Springer Science + Business Media

    David Selwood

  55. Control of spasticity in a multiple sclerosis model using central nervous system‐excluded CB 1 cannabinoid receptor agonists

    Article • The FASEB Journal, October 2013, Wiley

    David Selwood

  56. Genetic Background Can Result in a Marked or Minimal Effect of Gene Knockout (GPR55 and CB2 Receptor) in Experimental Autoimmune Encephalomyelitis Models of Multiple Sclerosis

    Article • PLoS ONE, October 2013, PLOS

    David Selwood

  57. Tuftsin signals through its receptor neuropilin‐1 via the transforming growth factor beta pathway

    Article • Journal of Neurochemistry, September 2013, Wiley

    David Selwood

  58. HIV-1 uncoating in human CD4+ T cells: kinetic and functional analyses

    Article • Retrovirology, September 2013, Springer Science + Business Media

    David Selwood

  59. Beyond the Hundred Dollar Genome – Drug Discovery Futures

    Article • Chemical Biology & Drug Design, December 2012, Wiley

    David Selwood

  60. Targeted delivery via avidin fusion protein: Intracellular fate of biotinylated doxorubicin derivative and cellular uptake kinetics and biodistribution of biotinylated liposomes

    Article • European Journal of Pharmaceutical Sciences, December 2012, Elsevier

    Dr Seppo Yla-Herttuala, David Selwood

  61. siRNA Delivery: From Lipids to Cell‐penetrating Peptides and Their Mimics

    Article • Chemical Biology & Drug Design, October 2012, Wiley

    David Selwood

  62. The Role of Chemical Biology in Understanding and Treating Disease‐Are Small Molecule “Correctors” the Way of the Future?

    Article • August 2012, Wiley

    David Selwood

  63. A mitochondrial-targeted cyclosporin A with high binding affinity for cyclophilin D yields improved cytoprotection of cardiomyocytes

    Article • Biochemical Journal, January 2012, Portland Press Ltd.

    David Selwood

  64. Marvellous Chemical Biology Tools and Other Matters

    Article • Chemical Biology & Drug Design, December 2011, Wiley

    David Selwood

  65. Exploring the Interaction Between siRNA and the SMoC Biomolecule Transporters: Implications for Small Molecule–Mediated Delivery of siRNA

    Article • Chemical Biology & Drug Design, November 2011, Wiley

    David Selwood

  66. Gyrase B Inhibitor Impairs HIV-1 Replication by Targeting Hsp90 and the Capsid Protein

    Article • Journal of Biological Chemistry, December 2010, Elsevier

    David Selwood

  67. Chemical Fragments that Hydrogen Bond to Asp, Glu, Arg, and His Side Chains in Protein Binding Sites

    Article • Journal of Medicinal Chemistry, March 2010, American Chemical Society (ACS)

    David Selwood

  68. Small Molecule Inhibitors of the Neuropilin-1 Vascular Endothelial Growth Factor A (VEGF-A) Interaction

    Article • Journal of Medicinal Chemistry, February 2010, American Chemical Society (ACS)

    David Selwood

  69. Neuropilin-1 antagonism in human carcinoma cells inhibits migration and enhances chemosensitivity

    Article • British Journal of Cancer, January 2010, Springer Science + Business Media

    David Selwood

  70. Mitochondrial targeting of cyclosporin A enables selective inhibition of cyclophilin-D and enhanced cytoprotection after glucose and oxygen deprivation

    Article • Biochemical Journal, December 2009, Portland Press Ltd.

    David Selwood

  71. Oxadiazolylindazole Sodium Channel Modulators are Neuroprotective toward Hippocampal Neurones

    Article • Journal of Medicinal Chemistry, April 2009, American Chemical Society (ACS)

    David Selwood

  72. Modular Assembly Using Sequential Palladium Coupling Gives Easy Access to the SMoC Class of Cellular Transporters

    Article • ChemBioChem, July 2008, Wiley

    David Selwood

  73. Vascular pharmacology of a novel cannabinoid‐like compound, 3‐(5‐dimethylcarbamoyl‐pent‐1‐enyl)‐N‐(2‐hydroxy‐1‐methyl‐ethyl)benzamide (VSN16) in the rat

    Article • British Journal of Pharmacology, November 2007, Wiley

    David Selwood

  74. Discovery of inhibitors of the pentein superfamily protein dimethylarginine dimethylaminohydrolase (DDAH), by virtual screening and hit analysis

    Article • Bioorganic & Medicinal Chemistry Letters, July 2007, Elsevier

    David Selwood

  75. Disruption of methylarginine metabolism impairs vascular homeostasis

    Article • Nature Reports Stem Cells, February 2007, Springer Science + Business Media

    David Selwood

  76. Small-molecule mimics of an α-helix for efficient transport of proteins into cells

    Article • Nature Methods, January 2007, Springer Science + Business Media

    David Selwood

  77. Characterization of a Bicyclic Peptide Neuropilin-1 (NP-1) Antagonist (EG3287) Reveals Importance of Vascular Endothelial Growth Factor Exon 8 for NP-1 Binding and Role of NP-1 in KDR Signaling

    Article • Journal of Biological Chemistry, May 2006, Elsevier

    David Selwood

  78. A concise approach to the epidithiodiketopiperazine (ETP) core

    Article • Tetrahedron Letters, April 2006, Elsevier

    David Selwood

  79. Aurora A and B kinases as targets for cancer: will they be selective for tumors?

    Article • Expert Review of Anticancer Therapy, January 2006, Taylor & Francis

    David Selwood

  80. Imatinib binding and cKIT inhibition is abrogated by the cKIT kinase domain I missense mutation Val654Ala

    Article • Molecular Cancer Therapeutics, December 2005, American Association for Cancer Research (AACR)

    David Selwood

  81. Selective Substrate-Based Inhibitors of Mammalian Dimethylarginine Dimethylaminohydrolase

    Article • Journal of Medicinal Chemistry, June 2005, American Chemical Society (ACS)

    David Selwood

  82. Observations on the reactivity of thiyl radicals derived from 3,6-epidithiodiketopiperazine-2,5-diones and related congeners

    Article • Bioorganic & Medicinal Chemistry Letters, May 2005, Elsevier

    David Selwood

  83. Membrane Receptor Probes:  Solid-Phase Synthesis of Biotin-Asp-PEG-arvanil Derivatives

    Article • Organic Letters, April 2005, American Chemical Society (ACS)

    David Selwood

  84. Erratum: Anticancer drug development: preclinical screening, clinical trials and approval

    Article • British Journal of Cancer, November 2004, Springer Science + Business Media

    David Selwood

  85. An Expedient Entry into the α-Mercaptodiketopiperazine Nucleus

    Article • Synlett, October 2004, Thieme Publishing Group

    Stephen Hilton, David Selwood

  86. Anticancer Drug Development: Preclinical Screening, Clinical Trials and Approval

    Article • British Journal of Cancer, August 2004, Springer Science + Business Media

    David Selwood

  87. Anti-chemorepulsive Effects of Vascular Endothelial Growth Factor and Placental Growth Factor-2 in Dorsal Root Ganglion Neurons Are Mediated via Neuropilin-1 and Cyclooxygenase-derived Prostanoid Production

    Article • Journal of Biological Chemistry, July 2004, Elsevier

    David Selwood

  88. Copper (II)-Mediated Arylation with Aryl Boronic Acids for the N-Derivatization of Pyrazole Libraries

    Article • Journal of Combinatorial Chemistry, February 2004, American Chemical Society (ACS)

    David Selwood

  89. A peptide encoded by exon 6 of VEGF (EG3306) inhibits VEGF-induced angiogenesis in vitro and ischaemic retinal neovascularisation in vivo

    Article • Biochemical and Biophysical Research Communications, March 2003, Elsevier

    David Selwood

  90. A Stable Bis-Allyloxycarbonyl Biotin Aldehyde Derivative for Biotinylation via Reductive Alkylation:  Application to the Synthesis of a Biotinylated Doxorubicin Derivative

    Article • Bioconjugate Chemistry, January 2003, American Chemical Society (ACS)

    Dr Seppo Yla-Herttuala, David Selwood

  91. Small HIV-1-Tat peptides inhibit HIV replication in cultured T-cells

    Article • Biochemical and Biophysical Research Communications, January 2003, Elsevier

    David Selwood

  92. Cysteine-Rich and Basic Domain HIV-1 Tat Peptides Inhibit Angiogenesis and Induce Endothelial Cell Apoptosis

    Article • Biochemical and Biophysical Research Communications, June 2001, Elsevier

    David Selwood

  93. Cysteine-Rich and Basic Domain HIV-1 Tat Peptides Inhibit Angiogenesis and Induce Endothelial Cell Apoptosis

    Article • Biochemical and Biophysical Research Communications, May 2001, Elsevier

    David Selwood

  94. Peptides Encoded by Exon 6 of VEGF Inhibit Endothelial Cell Biological Responses and Angiogenesis Induced by VEGF

    Article • Biochemical and Biophysical Research Communications, April 2001, Elsevier

    David Selwood

  95. Solution-phase parallel synthesis of 5-carboxamido 1-benzyl-3-(3-dimethylaminopropyloxy)-1H-pyrazoles as activators of soluble guanylate cyclase with improved oral bioavailability

    Article • Bioorganic & Medicinal Chemistry Letters, April 2001, Elsevier

    David Selwood

  96. Discovery of 4-[3-(trans-3-Dimethylaminocyclobutyl)-1H-indol-5-ylmethyl]- (4S)-oxazolidin-2-one (4991W93), a 5HT1B/1DReceptor Partial Agonist and a Potent Inhibitor of Electrically Induced Plasma Extravasation

    Article • Journal of Medicinal Chemistry, January 2001, American Chemical Society (ACS)

    David Selwood

  97. Synthesis and Biological Evaluation of Novel Pyrazoles and Indazoles as Activators of the Nitric Oxide Receptor, Soluble Guanylate Cyclase

    Article • Journal of Medicinal Chemistry, November 2000, American Chemical Society (ACS)

    David Selwood

  98. Synthesis and biological evaluation of enantiopure thionitrites: The solid-phase synthesis and nitrosation of d -glutathione as a molecular probe

    Article • Bioorganic & Medicinal Chemistry Letters, April 2000, Elsevier

    David Selwood

  99. New Synthesis of KT5823 Indolocarbazole Aglycone

    Article • Heterocycles, January 2000, Japan Institute of Heterocyclic Chemistry

    David Selwood

  100. Synthesis and biological evaluation of the L-enantiomer of 2′-deoxy-5-ethyl-4′-thiouridine

    Article • Bioorganic & Medicinal Chemistry Letters, April 1996, Elsevier

    David Selwood

  101. Synthesis and Anti-Herpes Activity of a Series of Indolizines

    Article • Antiviral Chemistry and Chemotherapy, October 1995, SAGE Publications

    David Selwood

  102. 4'-Thio-Nucleosides via in Situ Pyranose-Furanose Rearrangements: A Short Synthesis of the Antiherpes Agent 2'-Deoxy-5-ethyl-4'-thiouridine via Direct Coupling of a Silylated Pyrimidine Base with a 4-Thiopyranose Sugar

    Article • The Journal of Organic Chemistry, August 1995, American Chemical Society (ACS)

    David Selwood

  103. Isosteres of the DNA polymerase inhibitor aphidicolin as potential antiviral agents against human herpes viruses

    Article • Journal of Medicinal Chemistry, November 1993, American Chemical Society (ACS)

    David Selwood

  104. Glucose transport inAcanthocheilonema viteae

    Article • Parasitology, October 1990, Cambridge University Press

    David Selwood

  105. The effect of two novel analogues of antimycin A on oxygen consumption and survival of filarial nematodes in vitro

    Article • Molecular and Biochemical Parasitology, January 1990, Elsevier

    David Selwood

  106. Structure-activity relationships of antifilarial antimycin analogs: a multivariate pattern recognition study

    Article • Journal of Medicinal Chemistry, January 1990, American Chemical Society (ACS)

    David Selwood

  107. Synthetic studies towards the pinguisanes; synthesis of 4-epi-pinguisone

    Article • Journal of the Chemical Society Perkin Transactions 1, January 1988, Royal Society of Chemistry

    David Selwood

  108. A New, Efficient Synthesis of 5-Undecyl-6-hydroxy-4,7-dioxobenzothiazole (UHDBT), a Potent Electron Transport Inhibitor

    Article • Heterocycles, January 1988, Japan Institute of Heterocyclic Chemistry

    David Selwood

  109. Energy metabolism in parasitic filariae I: oxygen-uptake studies

    Article • Biochemical Society Transactions, December 1987, Portland Press Ltd.

    David Selwood

  110. Energy metabolism in parasitic filariae II: levels of nucleotides and end-products

    Article • Biochemical Society Transactions, December 1987, Portland Press Ltd.

    David Selwood

  111. Ortho-aminoacetophenone: A component of the sex pheromone system of the web-spinning larch sawfly,Cephalcia lariciphila wachtl

    Article • Cellular and Molecular Life Sciences, September 1983, Springer Science + Business Media

    David Selwood

  112. Sequential claisen and cope rearrangement for formation of 3-(-1-methylethyl)-substituted α,β-unsaturated aldehydes

    Article • Tetrahedron Letters, January 1982, Elsevier

    David Selwood