All Stories

  1. In-situserial crystallography facilitates 96-well plate structural analysis at low symmetry

    Article • April 2024, Cold Spring Harbor Laboratory Press

    Dr Matthew W Bowler

  2. Metal fluorides - multi-functional tools for the study of phosphoryl transfer enzymes

    Article • March 2024, Cold Spring Harbor Laboratory Press

    Dr Matthew W Bowler

  3. The MAP2Ks can use ADP to phosphorylate and activate their substrate MAPKsin vitro

    Article • February 2024, Cold Spring Harbor Laboratory Press

    Dr Matthew W Bowler

  4. EasyGrid: a versatile platform for automated cryo-EM sample preparation and quality control

    Article • January 2024, Cold Spring Harbor Laboratory Press

    Dr Matthew W Bowler

  5. The assembly of the Mitochondrial Complex I Assembly complex uncovers a redox pathway coordination

    Article • Nature Communications, December 2023, Springer Science + Business Media

    Dr Matthew W Bowler

  6. Architecture of the MKK6-p38α complex defines the basis of MAPK specificity and activation

    Article • Science, September 2023, American Association for the Advancement of Science

    Dr Matthew W Bowler

  7. High-Confidence Placement of Fragments into Electron Density Using Anomalous Diffraction—A Case Study Using Hits Targeting SARS-CoV-2 Non-Structural Protein 1

    Article • International Journal of Molecular Sciences, July 2023, MDPI AG

    Dr Matthew W Bowler

  8. The T2 structure of polycrystalline cubic human insulin

    Article • Acta Crystallographica Section D Structural Biology, April 2023, International Union of Crystallography

    Dr Irene Margiolaki, Dr Matthew W Bowler

  9. Identification, binding, and structural characterization of single domain anti-PD-L1 antibodies inhibitory of immune regulatory proteins PD-1 and CD80

    Article • Journal of Biological Chemistry, January 2023, Elsevier

    Dr Matthew W Bowler

  10. Two Ligand-Binding Sites on SARS-CoV-2 Non-Structural Protein 1 Revealed by Fragment-Based X-ray Screening

    Article • International Journal of Molecular Sciences, October 2022, MDPI AG

    Dr Matthew W Bowler

  11. Altiratinib blocks Toxoplasma gondii and Plasmodium falciparum development by selectively targeting a spliceosome kinase

    Article • Science Translational Medicine, August 2022, American Association for the Advancement of Science

    Dr Matthew W Bowler

  12. Structural insights into the substrate-bound condensation domains of non-ribosomal peptide synthetase AmbB

    Article • Scientific Reports, March 2022, Springer Science + Business Media

    Dr Matthew W Bowler

  13. Finding order in chaos – nanocrystals in amorphous protein gels

    Article • Acta Crystallographica Section F Structural Biology Communications, November 2021, International Union of Crystallography

    Dr Matthew W Bowler

  14. A plant-like mechanism coupling m6A reading to polyadenylation safeguards transcriptome integrity and developmental gene partitioning in Toxoplasma

    Article • eLife, July 2021, eLife

    Dr Matthew W Bowler

  15. Cross-Reactive SARS-CoV-2 Neutralizing Antibodies From Deep Mining of Early Patient Responses

    Article • Frontiers in Immunology, June 2021, Frontiers

    Dr Matthew W Bowler

  16. Structural and functional comparison of fumarylacetoacetate domain containing protein 1 in human and mouse

    Article • Bioscience Reports, March 2020, Portland Press Ltd.

    Dr Matthew W Bowler

  17. Structural plasticity in a human blood transport protein

    Article • Acta Crystallographica Section D Structural Biology, November 2019, International Union of Crystallography

    Bernhard Rupp, Dr Matthew W Bowler

  18. A comparative anatomy of protein crystals

    Article • IUCrJ, July 2019, International Union of Crystallography

    Dr Matthew W Bowler

  19. Fully Autonomous Characterization and Data Collection from Crystals of Biological Macromolecules

    Article • Journal of Visualized Experiments, March 2019, MyJove Corporation

    Dr Matthew W Bowler

  20. A molecular mechanism for transthyretin amyloidogenesis

    Article • Nature Communications, February 2019, Springer Science + Business Media

    Dr Matthew P Blakeley, Dr Matthew W Bowler

  21. MXCuBE2: the dawn of MXCuBE Collaboration

    Article • Journal of Synchrotron Radiation, February 2019, International Union of Crystallography

    Dr Matthew W Bowler

  22. A comparative anatomy of protein crystals: lessons from the automatic processing of 56,000 samples

    Article • February 2019, Cold Spring Harbor Laboratory Press

    Dr Matthew W Bowler

  23. CrystalDirect-To-Beam: Opening the shortest path from crystal to data

    Article • January 2019, American Institute of Physics

    Dr Matthew W Bowler

  24. Structural basis for the bi-functionality of human oxaloacetate decarboxylase FAHD1

    Article • Biochemical Journal, October 2018, Portland Press Ltd.

    Dr Matthew W Bowler

  25. Structural basis for Scc3-dependent cohesin recruitment to chromatin

    Article • eLife, August 2018, eLife

    Dr Matthew W Bowler

  26. Structural basis for reactivating the mutant TERT promoter by cooperative binding of p52 and ETS1

    Article • Nature Communications, August 2018, Springer Science + Business Media

    Dr Matthew W Bowler, Yinghui Li

  27. van der Waals Contact between Nucleophile and Transferring Phosphorus Is Insufficient To Achieve Enzyme Transition-State Architecture

    Article • ACS Catalysis, July 2018, American Chemical Society (ACS)

    Dr Matthew W Bowler

  28. A novel amyloid designable scaffold and potential inhibitor inspired by GAIIG of amyloid beta and the HIV-1 V3 loop

    Article • FEBS Letters, June 2018, Wiley

    Dr Antonio L Llamas-Saiz, Dr Matthew W Bowler

  29. Improving automatic data collection algorithms to cope with the most challenging protein samples

    Article • Acta Crystallographica Section D Structural Biology, April 2018, International Union of Crystallography

    Dr Matthew W Bowler

  30. A new MR-SAD algorithm for the automatic building of protein models from low-resolution X-ray data and a poor starting model

    Article • IUCrJ, January 2018, International Union of Crystallography

    Dr Matthew W Bowler

  31. Structural Evidence for a Role of the Multi-functional Human Glycoprotein Afamin in Wnt Transport

    Article • Structure, December 2017, Elsevier

    Dr Matthew W Bowler, Didier Nurizzo

  32. Towards a compact and precise sample holder for macromolecular crystallography

    Article • Acta Crystallographica Section D Structural Biology, September 2017, International Union of Crystallography

    Dr Matthew W Bowler

  33. FlexED8: the first member of a fast and flexible sample-changer family for macromolecular crystallography

    Article • Acta Crystallographica Section D Structural Biology, September 2017, International Union of Crystallography

    Dr Matthew W Bowler

  34. Assessing the Influence of Mutation on GTPase Transition States by Using X-ray Crystallography, 19 F NMR, and DFT Approaches

    Article • Angewandte Chemie International Edition, May 2017, Wiley

    Dr Matthew W Bowler

  35. Maintaining the correct humidity for biological samples

    Article • Journal of Applied Crystallography, March 2017, International Union of Crystallography

    Dr Matthew W Bowler

  36. Computational design of amyloid self-assembling peptides bearing aromatic residues and the cell adhesive motif Arg-Gly-Asp

    Article • Molecular Systems Design & Engineering, January 2017, Royal Society of Chemistry

    Dr Matthew W Bowler

  37. Observing enzyme ternary transition state analogue complexes by 19F NMR spectroscopy

    Article • Chemical Science, January 2017, Royal Society of Chemistry

    Dr Matthew W Bowler

  38. Self-Assembled Amyloid Peptides with Arg-Gly-Asp (RGD) Motifs As Scaffolds for Tissue Engineering

    Article • ACS Biomaterials Science & Engineering, November 2016, American Chemical Society (ACS)

    Dr Matthew W Bowler

  39. Structural basis for specific recognition of pre-snRNA by Gemin5

    Article • Cell Research, November 2016, Nature

    Dr Matthew W Bowler

  40. Toxoplasma's immunogenic balancing act explained

    Article • Structure, November 2016, Elsevier

    Dr Matthew W Bowler

  41. Designing an autonomous system for protein crystallography

    Article • Acta Crystallographica Section D Structural Biology, July 2016, International Union of Crystallography

    Dr Matthew W Bowler, Didier Nurizzo

  42. Structural basis of suppression of host translation termination by Moloney Murine Leukemia Virus

    Article • Nature Communications, June 2016, Nature

    Dr Matthew W Bowler

  43. Structural basis for blocking PD-1-mediated immune suppression by therapeutic antibody pembrolizumab

    Article • Cell Research, June 2016, Nature

    Dr Matthew W Bowler

  44. An autonomous system to perform complex experiments for biologists

    Article • Crystallography Reviews, March 2016, Taylor & Francis

    Dr Matthew W Bowler, Didier Nurizzo

  45. Automated data collection based on RoboDiff at the ESRF beamline MASSIF-1

    Article • January 2016, American Institute of Physics

    Dr Matthew W Bowler, Didier Nurizzo

  46. A beamline that runs experiments by itself

    Article • Journal of Synchrotron Radiation, October 2015, International Union of Crystallography

    Dr Matthew W Bowler, IUCr Journals

  47. The sweet quartet: Binding of fucose to the norovirus capsid

    Article • Virology, September 2015, Elsevier

    Dr Matthew W Bowler

  48. Protein crystallography becomes hands free

    Article • Acta Crystallographica Section D Biological Crystallography, July 2015, International Union of Crystallography

    Dr Matthew W Bowler, IUCr Journals, Didier Nurizzo

  49. Purification and characterization of DR_2577 (SlpA) a major S-layer protein from Deinococcus radiodurans

    Article • Frontiers in Microbiology, June 2015, Frontiers

    Dr Matthew W Bowler

  50. The status of the macromolecular crystallography beamlines at the European Synchrotron Radiation Facility

    Article • The European Physical Journal Plus, April 2015, Springer Science + Business Media

    Dr Matthew W Bowler, Dr Antoine Royant, Didier Nurizzo

  51. Automation and Experience of Controlled Crystal Dehydration: Results from the European Synchrotron HC1 Collaboration

    Article • Crystal Growth & Design, March 2015, American Chemical Society (ACS)

    Dr Matthew W Bowler

  52. ISPyB for BioSAXS, the gateway to user autonomy in solution scattering experiments

    Article • Acta Crystallographica Section D Biological Crystallography, January 2015, International Union of Crystallography

    Dr Matthew W Bowler

  53. α-Fluorophosphonates reveal how a phosphomutase conserves transition state conformation over hexose recognition in its two-step reaction

    Article • Proceedings of the National Academy of Sciences, August 2014, Proceedings of the National Academy of Sciences

    Dr Matthew W Bowler

  54. New features of the cell wall of the radio-resistant bacterium Deinococcus radiodurans

    Article • Biochimica et Biophysica Acta (BBA) - Biomembranes, July 2014, Elsevier

    Dr Matthew W Bowler

  55. Measuring crystal quality

    Article • Acta Crystallographica Section F Structural Biology Communications, December 2013, International Union of Crystallography

    Dr Matthew W Bowler

  56. QsIA disrupts LasR dimerization in antiactivation of bacterial quorum sensing

    Article • Proceedings of the National Academy of Sciences, December 2013, Proceedings of the National Academy of Sciences

    Dr Matthew W Bowler

  57. Lsm2 and Lsm3 bridge the interaction of the Lsm1-7 complex with Pat1 for decapping activation

    Article • Cell Research, November 2013, Nature

    Dr Matthew W Bowler

  58. Le rayonnement synchrotron : comprendre la relation structure-fonction des macromolécules biologiques

    Article • Reflets de la physique, June 2013, EDP Sciences

    Dr Matthew W Bowler, Didier Nurizzo

  59. Conformational dynamics in phosphoglycerate kinase, an open and shut case?

    Article • FEBS Letters, May 2013, Wiley

    Dr Matthew W Bowler

  60. Automatic processing of macromolecular crystallography X-ray diffraction data at the ESRF

    Article • Journal of Applied Crystallography, May 2013, International Union of Crystallography

    Dr Matthew W Bowler

  61. Recent progress in robot-based systems for crystallography and their contribution to drug discovery

    Article • Expert Opinion on Drug Discovery, May 2013, Informa Healthcare

    Dr Matthew W Bowler, Didier Nurizzo

  62. The Upgrade Programme for the Structural Biology beamlines at the European Synchrotron Radiation Facility – High throughput sample evaluation and automation

    Article • Journal of Physics Conference Series, March 2013, Institute of Physics Publishing

    Dr Matthew W Bowler

  63. Structural Basis of the PNRC2-Mediated Link between mRNA Surveillance and Decapping

    Article • Structure, December 2012, Elsevier

    Dr Matthew W Bowler, Yoon ki Kim

  64. Charge-Balanced Metal Fluoride Complexes for Protein Kinase A with Adenosine Diphosphate and Substrate Peptide SP20

    Article • Angewandte Chemie, November 2012, Wiley

    Dr Matthew W Bowler

  65. Charge-Balanced Metal Fluoride Complexes for Protein Kinase A with Adenosine Diphosphate and Substrate Peptide SP20

    Article • Angewandte Chemie International Edition, November 2012, Wiley

    Dr Matthew W Bowler

  66. Reflections on biocatalysis involving phosphorus

    Article • Biochemistry (Moscow), October 2012, Pleiades Publishing Ltd

    Dr Matthew W Bowler

  67. The Ighmbp2 helicase structure reveals the molecular basis for disease-causing mutations in DMSA1

    Article • Nucleic Acids Research, September 2012, Oxford University Press (OUP)

    Dr Matthew W Bowler

  68. The use of workflows in the design and implementation of complex experiments in macromolecular crystallography

    Article • Acta Crystallographica Section D Biological Crystallography, July 2012, International Union of Crystallography

    Dr Matthew W Bowler

  69. Crystal Structures of Lsm3, Lsm4 and Lsm5/6/7 from Schizosaccharomyces pombe

    Article • PLoS ONE, May 2012, PLOS

    Dr Matthew W Bowler

  70. Near attack conformers dominate β-phosphoglucomutase complexes where geometry and charge distribution reflect those of substrate

    Article • Proceedings of the National Academy of Sciences, April 2012, Proceedings of the National Academy of Sciences

    Dr Matthew W Bowler

  71. Matching the water content in a solution to relative humidity in air

    Article • Acta Crystallographica Section F Structural Biology and Crystallization Communications, December 2011, International Union of Crystallography

    Dr Matthew W Bowler

  72. Cool protein crystals easily

    Article • Acta Crystallographica Section D Biological Crystallography, September 2011, International Union of Crystallography

    Dr Matthew W Bowler

  73. Inducing phase changes in crystals of macromolecules: Status and perspectives for controlled crystal dehydration

    Article • Journal of Structural Biology, August 2011, Elsevier

    Dr Matthew W Bowler

  74. Interaction of Human 3-Phosphoglycerate Kinase with Its Two Substrates: Is Substrate Antagonism a Kinetic Advantage?

    Article • Journal of Molecular Biology, June 2011, Elsevier

    Dr Matthew W Bowler

  75. A Spring-loaded Release Mechanism Regulates Domain Movement and Catalysis in Phosphoglycerate Kinase

    Article • Journal of Biological Chemistry, February 2011, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Matthew W Bowler

  76. MX automation: towards a new sample holder standard for frozen crystals

    Article • Acta Crystallographica Section A Foundations of Crystallography, August 2010, International Union of Crystallography

    Dr Matthew W Bowler

  77. MxCuBE: a synchrotron beamline control environment customized for macromolecular crystallography experiments

    Article • Journal of Synchrotron Radiation, July 2010, International Union of Crystallography

    Dr Matthew W Bowler, Dr Martin Austin Walsh

  78. Locating and mapping the internal quality of protein crystals

    Article • Acta Crystallographica Section D Biological Crystallography, July 2010, International Union of Crystallography

    Dr Matthew W Bowler

  79. Transition State Analogue Structures of Human Phosphoglycerate Kinase Establish the Importance of Charge Balance in Catalysis

    Article • Journal of the American Chemical Society, May 2010, American Chemical Society (ACS)

    Dr Matthew W Bowler

  80. Atomic details of near-transition state conformers for enzyme phosphoryl transfer revealed by MgF3- rather than by phosphoranes

    Article • Proceedings of the National Academy of Sciences, February 2010, Proceedings of the National Academy of Sciences

    Dr Matthew W Bowler

  81. Why did Nature select phosphate for its dominant roles in biology?

    Article • New Journal of Chemistry, January 2010, Royal Society of Chemistry

    Dr Matthew W Bowler

  82. MgF 3 − and α-Galactose 1-Phosphate in the Active Site of β-Phosphoglucomutase Form a Transition State Analogue of Phosphoryl Transfer

    Article • Journal of the American Chemical Society, November 2009, American Chemical Society (ACS)

    Dr Matthew W Bowler

  83. Improving diffraction by humidity control: a novel device compatible with X-ray beamlines

    Article • Acta Crystallographica Section D Biological Crystallography, November 2009, International Union of Crystallography

    Dr Matthew W Bowler

  84. Ground State Structure of F1-ATPase from Bovine Heart Mitochondria at 1.9 A Resolution

    Article • Journal of Biological Chemistry, March 2007, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Matthew W Bowler

  85. Reproducible improvements in order and diffraction limit of crystals of bovine mitochondrial F1-ATPase by controlled dehydration

    Article • Acta Crystallographica Section D Biological Crystallography, August 2006, International Union of Crystallography

    Dr Matthew W Bowler

  86. How azide inhibits ATP hydrolysis by the F-ATPases

    Article • Proceedings of the National Academy of Sciences, June 2006, Proceedings of the National Academy of Sciences

    Dr Matthew W Bowler

  87. Increasing the diffraction limit and internal order of a membrane protein crystal by dehydration

    Article • Journal of Structural Biology, February 2003, Elsevier

    Dr Matthew W Bowler