All Stories

  1. Crystallisation of Zika NS5 RdRp v1

    Article • October 2024, ZappyLab, Inc.

    Dr Martin Austin Walsh

  2. Control of phosphodiesterase activity in the regulator of biofilm dispersal RbdA from Pseudomonas aeruginosa

    Article • RSC Chemical Biology, January 2024, Royal Society of Chemistry

    Dr Martin Austin Walsh

  3. Exploring the sequence-function space of microbial fucosidases

    Article • July 2023, Research Square

    Dr Martin Austin Walsh

  4. Studies on the selectivity of the SARS-CoV-2 papain-like protease reveal the importance of the P2' proline of the viral polyprotein

    Article • July 2023, Cold Spring Harbor Laboratory Press

    Dr Martin Austin Walsh

  5. Studies on the selectivity of the SARS-CoV-2 papain-like protease reveal the importance of the P2′ proline of the viral polyprotein

    Article • RSC Chemical Biology, January 2023, Royal Society of Chemistry

    Dr Martin Austin Walsh

  6. The structure of nontypeable Haemophilus influenzae SapA in a closed conformation reveals a constricted ligand-binding cavity and a novel RNA binding motif

    Article • PLoS ONE, October 2021, PLOS

    Dr Martin Austin Walsh

  7. Mass spectrometry reveals potential of β-lactams as SARS-CoV-2 Mpro inhibitors

    Article • Chemical Communications, January 2021, Royal Society of Chemistry

    Dr Martin Austin Walsh

  8. Diamond Light Source: contributions to SARS-CoV-2 biology and therapeutics

    Article • Biochemical and Biophysical Research Communications, November 2020, Elsevier

    Dr Martin Austin Walsh

  9. Super-Resolution Fluorescence Microscopy Reveals Clustering Behaviour of Chlamydia pneumoniae’s Major Outer Membrane Protein

    Article • Biology, October 2020, MDPI AG

    Dr Martin Austin Walsh

  10. Crystallographic and electrophilic fragment screening of the SARS-CoV-2 main protease

    Article • Nature Communications, October 2020, Springer Science + Business Media

    Dr Martin Austin Walsh

  11. An automatic pipeline for the design of irreversible derivatives identifies a potent SARS-CoV-2 Mpro inhibitor

    Article • September 2020, Cold Spring Harbor Laboratory Press

    Dr Martin Austin Walsh

  12. Crystallographic and electrophilic fragment screening of the SARS-CoV-2 main protease

    Article • May 2020, Cold Spring Harbor Laboratory Press

    Dr Martin Austin Walsh

  13. Fucosidases from the human gut symbiont Ruminococcus gnavus

    Article • Cellular and Molecular Life Sciences, April 2020, Springer Science + Business Media

    Dr Martin Austin Walsh

  14. Differential impact on motility and biofilm dispersal of closely related phosphodiesterases in Pseudomonas aeruginosa

    Article • Scientific Reports, April 2020, Springer Science + Business Media

    Dr Martin Austin Walsh

  15. Elucidation of a sialic acid metabolism pathway in mucus-foraging Ruminococcus gnavus unravels mechanisms of bacterial adaptation to the gut

    Article • Nature Microbiology, October 2019, Springer Science + Business Media

    Dr Martin Austin Walsh

  16. Structural insights into the molecular mechanisms of the Mycobacterium evolvability factor Mfd

    Article • August 2019, Cold Spring Harbor Laboratory Press

    Dr Martin Austin Walsh

  17. Differential impact on motility and biofilm dispersal of closely related phosphodiesterases in Pseudomonas aeruginosa

    Article • July 2019, Cold Spring Harbor Laboratory Press

    Dr Martin Austin Walsh

  18. The structure of Erwinia amylovora AvrRpt2 provides insight into protein maturation and induced resistance to fire blight by Malus × robusta 5

    Article • Journal of Structural Biology, March 2019, Elsevier

    Dr Martin Austin Walsh

  19. Structural and functional analysis of Erwinia amylovora SrlD. The first crystal structure of a sorbitol-6-phosphate 2-dehydrogenase

    Article • Journal of Structural Biology, August 2018, Elsevier

    Dr Martin Austin Walsh

  20. A complete structural characterization of the desferrioxamine E biosynthetic pathway from the fire blight pathogen Erwinia amylovora

    Article • Journal of Structural Biology, June 2018, Elsevier

    Dr Martin Austin Walsh

  21. iNEXT: a European facility network to stimulate translational structural biology

    Article • FEBS Letters, May 2018, Wiley

    Dr Martin Austin Walsh

  22. Where is crystallography going?

    Article • Acta Crystallographica Section D Structural Biology, February 2018, International Union of Crystallography

    Dr Gwyndaf Evans, Dr Martin Austin Walsh

  23. Interdomain conformational flexibility underpins the activity of UGGT, the eukaryotic glycoprotein secretion checkpoint

    Article • Proceedings of the National Academy of Sciences, July 2017, Proceedings of the National Academy of Sciences

    Dr Martin Austin Walsh

  24. Electron Bio-Imaging Centre (eBIC): the UK national research facility for biological electron microscopy

    Article • Acta Crystallographica Section D Structural Biology, May 2017, International Union of Crystallography

    Dr Martin Austin Walsh

  25. Dimerisation induced formation of the active site and the identification of three metal sites in EAL-phosphodiesterases

    Article • Scientific Reports, February 2017, Springer Science + Business Media

    Dr Martin Austin Walsh

  26. Structure of the Streptococcus pneumoniae carbohydrate substrate-binding protein SP0092

    Article • Acta Crystallographica Section F Structural Biology Communications, January 2017, International Union of Crystallography

    Dr Simone Culurgioni, Dr Martin Austin Walsh

  27. Structural Basis for Regulation and Specificity of Fructooligosaccharide Import in Streptococcus pneumoniae

    Article • Structure, December 2016, Elsevier

    Dr Simone Culurgioni, Dr Martin Austin Walsh

  28. Crystal structure of transketolase from the probiotic bacterium lactobacillus salivarius

    Article • Acta Crystallographica Section F Structural Biology Communications, September 2015, International Union of Crystallography

    Dr Martin Austin Walsh

  29. Streptococcus pneumoniaeNanC: Structural Insights into the Specificity and Mechanism of a Sialidase that Produces a Sialidase Inhibitor

    Article • Journal of Biological Chemistry, September 2015, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Martin Austin Walsh

  30. Ultrafast infrared spectroscopy reveals water-mediated coherent dynamics in an enzyme active site

    Article • Chemical Science, January 2015, Royal Society of Chemistry

    Dr Martin Austin Walsh

  31. Application of In Situ Diffraction in High-Throughput Structure Determination Platforms

    Article • November 2014, Springer Science + Business Media

    Dr Gwyndaf Evans, Dr Martin Austin Walsh, Dr Armin Wagner

  32. Targeting Cyclic di-GMP Signalling: A Strategy to Control Biofilm Formation?

    Article • Current Pharmaceutical Design, November 2014, Bentham Science Publishers

    Dr Martin Austin Walsh

  33. SynchLink: an iOS app for ISPyB

    Article • Journal of Applied Crystallography, September 2014, International Union of Crystallography

    Dr Martin Austin Walsh

  34. Crystal structure of an HD‐GYP domain cyclic‐di‐ GMP phosphodiesterase reveals an enzyme with a novel trinuclear catalytic iron centre

    Article • Molecular Microbiology, November 2013, Wiley

    Dr Martin Austin Walsh

  35. A structural and dynamic investigation of the inhibition of catalase by nitric oxide

    Article • Organic & Biomolecular Chemistry, January 2013, Royal Society of Chemistry

    Dr Martin Austin Walsh, Dr Paul A Hoskisson

  36. Structure of ribose 5-phosphate isomerase from the probiotic bacteriumLactobacillus salivariusUCC118

    Article • Acta Crystallographica Section F Structural Biology and Crystallization Communications, November 2012, International Union of Crystallography

    Dr Martin Austin Walsh

  37. Measuring protein dynamics with ultrafast two-dimensional infrared spectroscopy

    Article • Measurement Science and Technology, May 2012, Institute of Physics Publishing

    Dr Martin Austin Walsh, Dr Paul A Hoskisson

  38. ISPyB: an information management system for synchrotron macromolecular crystallography

    Article • Bioinformatics, September 2011, Oxford University Press (OUP)

    Dr Martin Austin Walsh

  39. Structural Basis for Streptococcus pneumoniae NanA Inhibition by Influenza Antivirals Zanamivir and Oseltamivir Carboxylate

    Article • Journal of Molecular Biology, June 2011, Elsevier

    Dr Martin Austin Walsh

  40. Structural Basis of the Sensor-Synthase Interaction in Autoinduction of the Quorum Sensing Signal DSF Biosynthesis

    Article • Structure, September 2010, Elsevier

    Lian-Hui Zhang, Dr Martin Austin Walsh

  41. MxCuBE: a synchrotron beamline control environment customized for macromolecular crystallography experiments

    Article • Journal of Synchrotron Radiation, July 2010, International Union of Crystallography

    Dr Matthew W Bowler, Dr Martin Austin Walsh

  42. Structural basis of YAP recognition by TEAD4 in the Hippo pathway

    Article • Genes & Development, February 2010, Cold Spring Harbor Laboratory Press

    Dr Martin Austin Walsh

  43. Allelic Variation of Bile Salt Hydrolase Genes in Lactobacillus salivarius Does Not Determine Bile Resistance Levels

    Article • Journal of Bacteriology, July 2009, ASM Journals

    Dr Martin Austin Walsh

  44. Structural basis for translational inhibition by the tumour suppressor Pdcd4

    Article • The EMBO Journal, January 2009, Wiley

    Dr Martin Austin Walsh

  45. Unusual Chromophore and Cross-Links in Ranasmurfin: A Blue Protein from the Foam Nests of a Tropical Frog

    Article • Angewandte Chemie, September 2008, Wiley

    Dr Martin Austin Walsh

  46. Unusual Chromophore and Cross-Links in Ranasmurfin: A Blue Protein from the Foam Nests of a Tropical Frog

    Article • Angewandte Chemie, September 2008, Wiley

    Dr Martin Austin Walsh

  47. Structural and functional studies of Streptococcus pneumoniae neuraminidase B: An intramolecular trans -sialidase

    Article • FEBS Letters, September 2008, Wiley

    Dr Martin Austin Walsh

  48. Crystal Structure of Human Edc3 and Its Functional Implications

    Article • Molecular and Cellular Biology, August 2008, ASM Journals

    Dr Martin Austin Walsh

  49. Crystal Structure of Human Kynurenine Aminotransferase II, a Drug Target for the Treatment of Schizophrenia

    Article • Journal of Biological Chemistry, December 2007, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Martin Austin Walsh

  50. Structure of the equine arteritis virus nucleocapsid protein reveals a dimer–dimer arrangement

    Article • Acta Crystallographica Section D Biological Crystallography, April 2007, International Union of Crystallography

    Dr Martin Austin Walsh

  51. Crystallization of Ranasmurfin, a blue-coloured protein fromPolypedates leucomystax

    Article • Acta Crystallographica Section F Structural Biology and Crystallization Communications, October 2006, International Union of Crystallography

    Dr Martin Austin Walsh

  52. Automation of sample mounting for macromolecular crystallography

    Article • Acta Crystallographica Section D Biological Crystallography, September 2006, International Union of Crystallography

    Dr Martin Austin Walsh

  53. The Structural Biology Center 19ID undulator beamline: facility specifications and protein crystallographic results

    Article • Journal of Synchrotron Radiation, December 2005, International Union of Crystallography

    Dr Gwyndaf Evans, Dr Martin Austin Walsh

  54. Overcoming the false-minima problem in direct methods: structure determination of the packaging enzyme P4 from bacteriophage ϕ13

    Article • Acta Crystallographica Section D Biological Crystallography, August 2005, International Union of Crystallography

    Dr Martin Austin Walsh

  55. Crystal Structures of Human DcpS in Ligand-free and m7GDP-bound forms Suggest a Dynamic Mechanism for Scavenger mRNA Decapping

    Article • Journal of Molecular Biology, April 2005, Elsevier

    Dr Martin Austin Walsh

  56. Going soft and SAD with manganese

    Article • Acta Crystallographica Section D Biological Crystallography, December 2004, International Union of Crystallography

    Dr Martin Austin Walsh, Dr Paula Salgado

  57. Crystallization and preliminary X-ray diffraction analysis of bacteriophage ϕ12 packaging factor P7

    Article • Acta Crystallographica Section D Biological Crystallography, November 2004, International Union of Crystallography

    Dr Martin Austin Walsh

  58. West Nile Virus Core Protein

    Article • Structure, July 2004, Elsevier

    Dr Martin Austin Walsh

  59. Crystal Structure and Functional Analysis of the Eukaryotic Class II Release Factor eRF3 from S. pombe

    Article • Molecular Cell, April 2004, Elsevier

    Dr Martin Austin Walsh

  60. A Novel ADP- and Zinc-binding fold from function-directed in vitro evolution

    Article • March 2004, Protein Data Bank, Rutgers University

    Dr Martin Austin Walsh

  61. A novel ADP- and zinc-binding fold from function-directed in vitro evolution

    Article • Nature Structural & Molecular Biology, March 2004, Nature

    Dr Martin Austin Walsh

  62. The nsp9 Replicase Protein of SARS-Coronavirus, Structure and Functional Insights

    Article • Structure, February 2004, Elsevier

    Dr Martin Austin Walsh

  63. The nsp9 Replicase Protein of SARS-Coronavirus, Structure and Functional Insights

    Article • Structure, February 2004, Elsevier

    Dr Martin Austin Walsh

  64. Crystal Structure of a Human VH:  Requirements for Maintaining a Monomeric Fragment † , ‡

    Article • Biochemistry, January 2004, American Chemical Society (ACS)

    Dr Martin Austin Walsh

  65. Structural Studies on Flavin Reductase PheA2 Reveal Binding of NAD in an Unusual Folded Conformation and Support Novel Mechanism of Action

    Article • Journal of Biological Chemistry, December 2003, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Willem J.H. van Berkel, Dr Martin Austin Walsh

  66. Soft-SAD crystal structure of a pheromone binding protein from the honeybee Apis mellifera L.

    Article • November 2003, Protein Data Bank, Rutgers University

    Dr Martin Austin Walsh

  67. Sulfur Single-wavelength Anomalous Diffraction Crystal Structure of a Pheromone-Binding Protein from the HoneybeeApis melliferaL

    Article • Journal of Biological Chemistry, October 2003, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Martin Austin Walsh

  68. Expression, purification, crystallization and preliminary crystallographic analysis of the calponin-homology domain of Rng2

    Article • Acta Crystallographica Section D Biological Crystallography, September 2003, International Union of Crystallography

    Dr Martin Austin Walsh

  69. Crystal structure of MboIIA methyltransferase

    Article • Nucleic Acids Research, September 2003, Oxford University Press (OUP)

    Dr Martin Austin Walsh

  70. The 2-A Crystal Structure of 6-Oxo Camphor Hydrolase: NEW STRUCTURAL DIVERSITY IN THE CROTONASE SUPERFAMILY

    Article • Journal of Biological Chemistry, November 2002, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Martin Austin Walsh

  71. Crystallographic Investigation of the Role of Aspartate 95 in the Modulation of the Redox Potentials of Desulfovibrio vulgaris Flavodoxin † , ‡

    Article • Biochemistry, September 2002, American Chemical Society (ACS)

    Dr Martin Austin Walsh

  72. Crystal structures of penicillin acylase enzyme-substrate complexes: structural insights into the catalytic mechanism 1 1Edited by K. Nagai

    Article • Journal of Molecular Biology, October 2001, Elsevier

    Dr Martin Austin Walsh

  73. A thermophilic mini-chaperonin contains a conserved polypeptide-binding surface: combined crystallographic and NMR studies of the GroEL apical domain with implications for substrate interactions11Edited by A. R. Fersht

    Article • Journal of Molecular Biology, February 2001, Elsevier

    Dr Martin Austin Walsh

  74. Inhibition of the Hepatitis C Virus NS3/4A Protease. The Crystal Structures of Two Protease-Inhibitor Complexes (inhibitor II)

    Article • January 2001, Protein Data Bank, Rutgers University

    Dr Martin Austin Walsh

  75. Inhibition of the Hepatitis C Virus NS3/4A Protease. The Crystal Structures of Two Protease-Inhibitor Complexes (apo structure)

    Article • January 2001, Protein Data Bank, Rutgers University

    Dr Martin Austin Walsh

  76. Structure of RsrI methyltransferase, a member of the N6-adenine beta class of DNA methyltransferases

    Article • Nucleic Acids Research, October 2000, Oxford University Press (OUP)

    Dr Martin Austin Walsh

  77. Structure of cyanase reveals that a novel dimeric and decameric arrangement of subunits is required for formation of the enzyme active site

    Article • Structure, May 2000, Elsevier

    Dr Martin Austin Walsh

  78. Inhibition of the Hepatitis C Virus NS3/4A Protease: THE CRYSTAL STRUCTURES OF TWO PROTEASE-INHIBITOR COMPLEXES

    Article • Journal of Biological Chemistry, March 2000, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Martin Austin Walsh

  79. Crystal structure of δ-chymotrypsin bound to a peptidyl chloromethyl ketone inhibitor

    Article • Acta Crystallographica Section D Biological Crystallography, March 2000, International Union of Crystallography

    Professor Jonathan Paul G. Malthouse, Dr Martin Austin Walsh

  80. MAD data collection – current trends

    Article • Acta Crystallographica Section D Biological Crystallography, October 1999, International Union of Crystallography

    Dr Gwyndaf Evans, Dr Martin Austin Walsh

  81. Taking MAD to the extreme: ultrafast protein structure determination

    Article • Acta Crystallographica Section D Biological Crystallography, June 1999, International Union of Crystallography

    Dr Gwyndaf Evans, Dr Martin Austin Walsh

  82. Structure of a new crystal form of human Hsp70 ATPase domain

    Article • Acta Crystallographica Section D Biological Crystallography, May 1999, International Union of Crystallography

    Dr Martin Austin Walsh

  83. Crystallization and preliminary crystallographic analysis of an NADH oxidase that functions in peroxide reduction inThermus aquaticusYT-1

    Article • Acta Crystallographica Section D Biological Crystallography, January 1999, International Union of Crystallography

    Dr Martin Austin Walsh

  84. X-ray crystal structure of the Desulfovibrio vulgaris (Hildenborough) apoflavodoxin-riboflavin complex

    Article • European Journal of Biochemistry, December 1998, Wiley

    Dr Martin Austin Walsh

  85. Refinement of Triclinic Hen Egg-White Lysozyme at Atomic Resolution

    Article • Acta Crystallographica Section D Biological Crystallography, July 1998, International Union of Crystallography

    Dr Martin Austin Walsh

  86. Modulation of the Redox Potentials of FMN in Desulfovibrio v ulgaris Flavodoxin:  Thermodynamic Properties and Crystal Structures of Glycine-61 Mutants † , ‡

    Article • Biochemistry, June 1998, American Chemical Society (ACS)

    Dr Martin Austin Walsh

  87. Crystallization and preliminary X-ray crystallographic analysis of the electron-transferring flavoprotein fromMegasphaera elsdenii

    Article • Acta Crystallographica Section D Biological Crystallography, July 1997, International Union of Crystallography

    Dr Martin Austin Walsh