All Stories

  1. Photochemical Internalization: Light Paves Way for New Cancer Chemotherapies and Vaccines

    Article • Cancers, January 2020, MDPI AG

    Pål Kristian Selbo

  2. Photochemical internalization of scFvCD133/rGelonin, a novel CD133-targeting immunotoxin

    Article • Journal of Clinical Medicine, December 2019, MDPI AG

    Pål Kristian Selbo

  3. Photochemical Internalization of Peptide Antigens Provides a Novel Strategy to Realize Therapeutic Cancer Vaccination

    Article • Frontiers in Immunology, April 2018, Frontiers

    Pål Kristian Selbo

  4. Enhanced targeting of triple-negative breast carcinoma and malignant melanoma by photochemical internalization of CSPG4-targeting immunotoxins

    Article • Photochemical & Photobiological Sciences, January 2018, Springer Science + Business Media

    Pål Kristian Selbo

  5. 5-FU resistant EMT-like pancreatic cancer cells are hypersensitive to photochemical internalization of the novel endoglin-targeting immunotoxin CD105-saporin

    Article • Journal of Experimental & Clinical Cancer Research, December 2017, Springer Science + Business Media

    Pål Kristian Selbo

  6. Development of resistance to photodynamic therapy (PDT) in human breast cancer cells is photosensitizer-dependent: Possible mechanisms and approaches for overcoming PDT-resistance

    Article • Biochemical Pharmacology, November 2017, Elsevier

    Pål Kristian Selbo

  7. Abstract A008: Photochemical internalization: Light-induced enhancement of MHC Class I antigen presentation, giving strong enhancement of cytotoxic T-cell responses to vaccination

    Article • Cancer Immunology Research, October 2016, American Association for Cancer Research (AACR)

    Pål Kristian Selbo

  8. Photochemical Internalization (PCI) — A Technology for Intracellular Drug Delivery

    Article • July 2016, World Scientific Pub Co Pte Lt

    Pål Kristian Selbo

  9. CHAPTER 9. Photochemical Internalization-Enhanced Targeting of Vasculature and Cancer Stem Cells—Present and Future Perspectives

    Article • January 2016, Royal Society of Chemistry

    Pål Kristian Selbo

  10. Light-controlled endosomal escape of the novel CD133-targeting immunotoxin AC133–saporin by photochemical internalization — A minimally invasive cancer stem cell-targeting strategy

    Article • Journal of Controlled Release, May 2015, Elsevier

    Pål Kristian Selbo

  11. Photochemical internalisation, a minimally invasive strategy for light-controlled endosomal escape of cancer stem cell-targeting therapeutics

    Article • Photochemical & Photobiological Sciences, January 2015, Springer Science + Business Media

    Pål Kristian Selbo

  12. Photochemical activation of drugs for the treatment of therapy-resistant cancers

    Article • Photochemical & Photobiological Sciences, January 2015, Springer Science + Business Media

    Pål Kristian Selbo

  13. Photosensitisation facilitates cross-priming of adjuvant-free protein vaccines and stimulation of tumour-suppressing CD8 T cells

    Article • Journal of Controlled Release, January 2015, Elsevier

    Pål Kristian Selbo

  14. 177Lu-DOTA-HH1, a Novel Anti-CD37 Radio-Immunoconjugate: A Study of Toxicity in Nude Mice

    Article • PLoS ONE, July 2014, PLOS

    Pål Kristian Selbo

  15. Light-Triggered, Efficient Cytosolic Release of IM7-Saporin Targeting the Putative Cancer Stem Cell Marker CD44 by Photochemical Internalization

    Article • Molecular Pharmaceutics, July 2014, American Chemical Society (ACS)

    Pål Kristian Selbo

  16. Diagnostic and therapeutic potential a novel EpCAM-targeting antibody

    Article • mAbs, February 2014, Taylor & Francis

    Pål Kristian Selbo

  17. Intradermal photosensitisation facilitates stimulation of MHC class-I restricted CD8 T-cell responses of co-administered antigen

    Article • Journal of Controlled Release, January 2014, Elsevier

    Pål Kristian Selbo

  18. Photochemical Internalization: A Novel Technology for Targeted Macromolecule Therapy

    Article • January 2014, Springer Science + Business Media

    Pål Kristian Selbo

  19. Circumvention of resistance to photodynamic therapy in doxorubicin-resistant sarcoma by photochemical internalization of gelonin

    Article • Free Radical Biology and Medicine, December 2013, Elsevier

    Pål Kristian Selbo

  20. Erratum to “Sustained ERK inhibition by EGFR targeting therapies is a predictive factor for synergistic cytotoxicity with PDT as neoadjuvant therapy” [Biochim. Biophys. Acta 1830 (2013) 2659–2670]

    Article • Biochimica et Biophysica Acta (BBA) - General Subjects, October 2013, Elsevier

    Pål Kristian Selbo

  21. Photochemical Internalization

    Article • September 2013, Taylor & Francis

    Pål Kristian Selbo

  22. Vascular endothelial cells as targets for photochemical internalization (PCI)

    Article • Photochemistry and Photobiology, August 2013, Wiley

    Pål Kristian Selbo

  23. Photochemical internalization of CD133-targeting immunotoxins efficiently depletes sarcoma cells with stem-like properties and reduces tumorigenicity

    Article • Biochimica et Biophysica Acta (BBA) - General Subjects, August 2013, Elsevier

    Pål Kristian Selbo

  24. Photochemical internalization (PCI) of immunotoxins targeting CD133 is specific and highly potent at femtomolar levels in cells with cancer stem cell properties

    Article • Journal of Controlled Release, June 2013, Elsevier

    Pål Kristian Selbo

  25. Abstract 1606: Photochemical internalization (PCI): a novel technology for site-specific drug delivery.

    Article • Cancer Research, April 2013, American Association for Cancer Research (AACR)

    Pål Kristian Selbo

  26. Sustained EKR inhibition by EGFR targeting therapies is a predictive factor for synergistic cytotoxicity with PDT as neoadjuvant therapy

    Article • Biochimica et Biophysica Acta (BBA) - General Subjects, March 2013, Elsevier

    Pål Kristian Selbo

  27. Epidermal growth factor receptor-targeted photosensitizer selectively inhibits EGFR signaling and induces targeted phototoxicity in ovarian cancer cells

    Article • Cancer Letters, August 2012, Elsevier

    Pål Kristian Selbo

  28. Abstract 3381: Photochemical internalization (PCI) of immunotoxins targeting cancer stem cell markers

    Article • Cancer Research, April 2012, American Association for Cancer Research (AACR)

    Pål Kristian Selbo

  29. Strongly amphiphilic photosensitizers are not substrates of the cancer stem cell marker ABCG2 and provides specific and efficient light-triggered drug delivery of an EGFR-targeted cytotoxic drug

    Article • Journal of Controlled Release, April 2012, Elsevier

    Pål Kristian Selbo

  30. Disulfonated tetraphenyl chlorin (TPCS2a), a novel photosensitizer developed for clinical utilization of photochemical internalization

    Article • Photochemical & Photobiological Sciences, October 2011, Springer Science + Business Media

    Pål Kristian Selbo

  31. 107 INVITED Fluorescence Guided Cancer Therapy

    Article • European Journal of Cancer, September 2011, Elsevier

    Pål Kristian Selbo

  32. Photochemical internalization of tumor-targeted protein toxins

    Article • Lasers in Surgery and Medicine, August 2011, Wiley

    Pål Kristian Selbo

  33. Photochemical internalization (PCI), a technology for site-specific drug delivery. Recent advances

    Article • Photodiagnosis and Photodynamic Therapy, June 2011, Elsevier

    Pål Kristian Selbo

  34. Photochemische Internalisierung (PCI): eine Weiterentwicklung der photodynamischen Therapie zur Behandlung von Hautkrebs

    Article • Praxis, November 2010, Hogrefe Publishing Group

    Pål Kristian Selbo

  35. Photochemical internalization provides time- and space-controlled endolysosomal escape of therapeutic molecules

    Article • Journal of Controlled Release, November 2010, Elsevier

    Pål Kristian Selbo

  36. The Potential of Photochemical Internalization (PCI) for the Cytosolic Delivery of Nanomedicines

    Article • August 2010, Wiley

    Pål Kristian Selbo

  37. Intracellular re-localisation by photochemical internalisation enhances the cytotoxic effect of gelonin — Quantitative studies in normal rat liver

    Article • Journal of Controlled Release, March 2010, Elsevier

    Pål Kristian Selbo

  38. Photochemical Internalization (PCI): A Technology for Drug Delivery

    Article • January 2010, Springer Science + Business Media

    Pål Kristian Selbo, Dr. Ernst Wagner

  39. Photochemical Internalization: A New Tool for Gene and Oligonucleotide Delivery

    Article • January 2010, Springer Science + Business Media

    Pål Kristian Selbo

  40. Multi-Modality Therapeutics with Potent Anti-Tumor Effects: Photochemical Internalization Enhances Delivery of the Fusion Toxin scFvMEL/rGel

    Article • PLoS ONE, August 2009, PLOS

    Pål Kristian Selbo

  41. Photochemical internalization (PCI) in cancer therapy: From bench towards bedside medicine

    Article • Journal of Photochemistry and Photobiology B Biology, August 2009, Elsevier

    Pål Kristian Selbo

  42. Photodynamic Therapy Targets the mTOR Signaling Networkin Vitroandin Vivo

    Article • Molecular Pharmaceutics, February 2009, American Chemical Society (ACS)

    Pål Kristian Selbo

  43. Photochemical Internalization: A New Tool for Drug Delivery

    Article • Current Pharmaceutical Biotechnology, December 2007, Bentham Science Publishers

    Pål Kristian Selbo, Dr. Ernst Wagner

  44. Evaluation of the Binding of Radiolabeled Rituximab to CD20-Positive Lymphoma Cells: An In Vitro Feasibility Study Concerning Low-Dose-Rate Radioimmunotherapy with the α-Emitter 227Th

    Article • Cancer Biotherapy & Radiopharmaceuticals, August 2007, Mary Ann Liebert Inc

    Pål Kristian Selbo

  45. Y1068 phosphorylation is the most sensitive target of disulfonated tetraphenylporphyrin-based photodynamic therapy on epidermal growth factor receptor

    Article • Biochemical Pharmacology, July 2007, Elsevier

    Pål Kristian Selbo

  46. 5-Aminolevulinic Acid-based Photochemical Internalization of the Immunotoxin MOC31-gelonin Generates Synergistic Cytotoxic Effects In Vitro¶

    Article • Photochemistry and Photobiology, May 2007, American Society for Photobiology

    Pål Kristian Selbo

  47. Targeted Delivery and Enhanced Cytotoxicity of Cetuximab−Saporin by Photochemical Internalization in EGFR-Positive Cancer Cells

    Article • Molecular Pharmaceutics, April 2007, American Chemical Society (ACS)

    Pål Kristian Selbo

  48. Photochemical internalization (PCI): A novel technology for activation of endocytosed therapeutic agents

    Article • Medical Laser Application, November 2006, Elsevier

    Pål Kristian Selbo

  49. Photochemical Internalization of Therapeutic Macromolecular Agents: A Novel Strategy to Kill Multidrug-Resistant Cancer Cells

    Article • Journal of Pharmacology and Experimental Therapeutics, August 2006, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Pål Kristian Selbo

  50. Mechanistic Investigation and Implications of Photodynamic Therapy Induction of Vascular Endothelial Growth Factor in Prostate Cancer

    Article • Cancer Research, June 2006, American Association for Cancer Research (AACR)

    Pål Kristian Selbo

  51. Photochemically stimulated drug delivery increases the cytotoxicity and specificity of EGF–saporin

    Article • Journal of Controlled Release, March 2006, Elsevier

    Pål Kristian Selbo

  52. Photochemical Internalization (PCI): A New Modality for Light Activation of Endocytosed Therapeuticals

    Article • Journal of Environmental Pathology Toxicology and Oncology, January 2006, Begell House

    Pål Kristian Selbo

  53. Enhanced photodynamic destruction of a transplantable fibrosarcoma using photochemical internalisation of gelonin

    Article • British Journal of Cancer, May 2005, Springer Science + Business Media

    Pål Kristian Selbo

  54. Porphyrin-related photosensitizers for cancer imaging and therapeutic applications

    Article • Journal of Microscopy, May 2005, Wiley

    Pål Kristian Selbo

  55. Photochemical internalisation in drug and gene delivery

    Article • Advanced Drug Delivery Reviews, January 2004, Elsevier

    Pål Kristian Selbo

  56. Light Directed Gene Transfer by Photochemical Internalisation

    Article • Current Gene Therapy, April 2003, Bentham Science Publishers

    Pål Kristian Selbo

  57. Photochemical disruption of endocytic vesicles before delivery of drugs: a new strategy for cancer therapy

    Article • British Journal of Cancer, February 2002, Springer Science + Business Media

    Pål Kristian Selbo

  58. Photochemical Internalisation: A Novel Drug Delivery System

    Article • Tumor Biology, January 2002, Springer Science + Business Media

    Pål Kristian Selbo

  59. 5-Aminolevulinic Acid–based Photochemical Internalization of the Immunotoxin MOC31-gelonin Generates Synergistic Cytotoxic Effects In Vitro¶

    Article • Photochemistry and Photobiology, January 2001, Wiley

    Pål Kristian Selbo

  60. In vivo documentation of photochemical internalization, a novel approach to site specific cancer therapy

    Article • International Journal of Cancer, January 2001, Wiley

    Pål Kristian Selbo

  61. Release of gelonin from endosomes and lysosomes to cytosol by photochemical internalization

    Article • Biochimica et Biophysica Acta (BBA) - General Subjects, July 2000, Elsevier

    Pål Kristian Selbo

  62. Photochemical internalisation increases the cytotoxic effect of the immunotoxin MOC31-gelonin

    Article • International Journal of Cancer, January 2000, Wiley

    Pål Kristian Selbo

  63. In-situ localization of a photosensitizer as evaluated by vital microscopy

    Article • December 1997, SPIE

    Pål Kristian Selbo

  64. Phospholipase A2 in Psoriasis

    Article • January 1997, Karger Publishers

    Pål Kristian Selbo