All Stories

  1. Chemoselective Synthesis and Anti-Kinetoplastidal Properties of 2,6-Diaryl-4H-tetrahydro-thiopyran-4-one S-Oxides: Their Interplay in a Cascade of Redox Reactions from Diarylideneacetones
  2. Synthesis and Photochemical Properties of Fluorescent Metabolites Generated from Fluorinated Benzoylmenadiones in Living Cells
  3. Evaluation of ferrocenyl-containing γ-hydroxy-γ-lactam-derived tetramates as potential antiplasmodials
  4. Efficient Multigram-Scale Synthesis of 7-Substituted 3-Methyltetral-1-ones and 6-Fluoromenadione
  5. The parasitophorous vacuole nutrient channel is critical for drug access in malaria parasites and modulates the artemisinin resistance fitness cost
  6. Bioinspired Photoredox Benzylation of Quinones
  7. Direct C−H Radical Alkylation of 1,4‐Quinones
  8. Magnesium Complexes of Ladanein: A Beneficial Strategy for Stabilizing Polyphenolic Antivirals
  9. A Class of Valuable (Pro-)Activity-Based Protein Profiling Probes: Application to the Redox-Active Antiplasmodial Agent, Plasmodione
  10. Plasmodium falciparum Ferredoxin-NADP+ Reductase-Catalyzed Redox Cycling of Plasmodione Generates Both Predicted Key Drug Metabolites: Implication for Antimalarial Drug Development
  11. Repurposing Auranofin and Evaluation of a New Gold(I) Compound for the Search of Treatment of Human and Cattle Parasitic Diseases: From Protozoa to Helminth Infections
  12. A role for the succinate dehydrogenase in the mode of action of the redox-active antimalarial drug, plasmodione
  13. A Mild and Versatile Friedel–Crafts Methodology for the Diversity‐Oriented Synthesis of Redox‐Active 3‐Benzoylmenadiones with Tuneable Redox Potentials
  14. A Mild and Versatile Friedel–Crafts Methodology for the Diversity‐Oriented Synthesis of Redox‐Active 3‐Benzoylmenadiones with Tunable Redox Potentials
  15. Antiplasmodial Activity of Nitroaromatic Compounds: Correlation with Their Reduction Potential and Inhibitory Action on Plasmodium falciparum Glutathione Reductase
  16. Investigating the mode of action of the redox-active antimalarial drug plasmodione using the yeast model
  17. Selenium Status in Elderly People: Longevity and Age-Related Diseases
  18. Author Correction: Arylmethylamino steroids as antiparasitic agents
  19. Physicochemical Properties Govern the Activity of Potent Antiviral Flavones
  20. AntiMalarial Mode of Action (AMMA) Database: Data Selection, Verification and Chemical Space Analysis
  21. Synthesis of plasmodione metabolites and13C-enriched plasmodione as chemical tools for drug metabolism investigation
  22. Iron(iii) coordination properties of ladanein, a flavone lead with a broad-spectrum antiviral activity
  23. QSAR modeling and chemical space analysis of antimalarial compounds
  24. A high susceptibility to redox imbalance of the transmissible stages of Plasmodium falciparum revealed with a luciferase‐based mature gametocyte assay
  25. Arylmethylamino steroids as antiparasitic agents
  26. Pharmacomodulation of the Antimalarial Plasmodione: Synthesis of Biaryl- and N-Arylalkylamine Analogues, Antimalarial Activities and Physicochemical Properties
  27. A Redox-Active Fluorescent pH Indicator for Detecting Plasmodium falciparum Strains with Reduced Responsiveness to Quinoline Antimalarial Drugs
  28. ChemInform Abstract: A Platform of Regioselective Methodologies to Access Polysubstituted 2-Methyl-1,4-naphthoquinone Derivatives: Scope and Limitations.
  29. In Silico Mining for Antimalarial Structure-Activity Knowledge and Discovery of Novel Antimalarial Curcuminoids
  30. The Redox Cycler Plasmodione Is a Fast-Acting Antimalarial Lead Compound with Pronounced Activity against Sexual and Early Asexual Blood-Stage Parasites
  31. A Platform of Regioselective Methodologies to Access Polysubstituted 2-Methyl-1,4-naphthoquinone Derivatives: Scope and Limitations
  32. Redox Polypharmacology as an Emerging Strategy to Combat Malarial Parasites
  33. Synthesis and evaluation of 1,4-naphthoquinone ether derivatives asSmTGR inhibitors and new anti-schistosomal drugs
  34. ChemInform Abstract: Diastereoselective Synthesis of 2,6-Diaryltetrahydrothiopyran-4-ones by Phase-Transfer Catalysis.
  35. Antimalarial NADPH-Consuming Redox-Cyclers As Superior Glucose-6-Phosphate Dehydrogenase Deficiency Copycats
  36. Diastereoselective Synthesis of 2,6-Diaryltetrahydrothiopyran-4-ones by Phase-Transfer Catalysis
  37. Electrochemical Properties of Substituted 2-Methyl-1,4-Naphthoquinones: Redox Behavior Predictions
  38. Antiglioma activity of GoPI-sugar, a novel gold(I)–phosphole inhibitor: Chemical synthesis, mechanistic studies, and effectiveness in vivo
  39. A Practical and Economical High-Yielding, Six-Step Sequence Synthesis of a Flavone: Application to the Multigram-Scale Synthesis of Ladanein
  40. Versatile Synthesis of Dissymmetric Diarylideneacetones via a Palladium-Catalyzed­ Coupling-Isomerization Reaction
  41. ChemInform Abstract: Versatile Synthesis of Dissymmetric Diarylideneacetones via a Palladium-Catalyzed Coupling-Isomerization Reaction.
  42. Redox-Active Agents in Reactions Involving the Trypanothione/Trypanothione Reductase-based System to Fight Kinetoplastidal Parasites
  43. 1,4-Naphthoquinones and Other NADPH-Dependent Glutathione Reductase- Catalyzed Redox Cyclers as Antimalarial Agents
  44. The Antimalarial Activities of Methylene Blue and the 1,4-Naphthoquinone 3-[4-(Trifluoromethyl)Benzyl]-Menadione Are Not Due to Inhibition of the Mitochondrial Electron Transport Chain
  45. Drug Discovery in Infectious Diseases, Volume 3: Parasitic Helminths: Targets, Screens, Drugs and Vaccines. Edited by Conor R. Caffrey
  46. Versatile Synthesis of Dissymmetric Diarylideneacetones via a Palladium-Catalyzed­ Coupling–Isomerization Reaction
  47. Interactions of the Antimalarial Drug Methylene Blue with Methemoglobin and Heme Targets inPlasmodium falciparum: A Physico-Biochemical Study
  48. A Plant-Derived Flavonoid Inhibits Entry of All HCV Genotypes Into Human Hepatocytes
  49. Synthesis and biological evaluation of 1,4-naphthoquinones and quinoline-5,8-diones as antimalarial and schistosomicidal agents
  50. Exploring the trifluoromenadione core as a template to design antimalarial redox-active agents interacting with glutathione reductase
  51. Glutathione Reductase-Catalyzed Cascade of Redox Reactions To Bioactivate Potent Antimalarial 1,4-Naphthoquinones – A New Strategy to Combat Malarial Parasites
  52. Subversive Substrates of Glutathione Reductases from Plasmodium falciparum-Infected Red Blood Cells as Antimalarial Agents
  53. ChemInform Abstract: New Steroidal Diazo Ketones as Potential Photoaffinity Labeling Reagents for the Mineralocorticoid Receptor: Synthesis and Biological Activities.
  54. ChemInform Abstract: New Potent Inhibitors of Trypanothione Reductase from Trypanosoma cruzi in the 2-Aminodiphenylsulfide Series.
  55. ChemInform Abstract: Structure-Activity Relationships in 2-Aminodiphenylsulfides Against Trypanothione Reductase from Trypanosoma cruzi.
  56. ChemInform Abstract: A General Approach to the Synthesis of Polyamine Linked-Monoindolylmaleimides, a New Series of Trypanothione Reductase Inhibitors.
  57. ChemInform Abstract: Automated Parallel Synthesis of a Tetrahydroisoquinolin-Based Library: Potential Prolyl Endopeptidase Inhibitors.
  58. Antimalarial versus Cytotoxic Properties of Dual Drugs Derived From 4-Aminoquinolines and Mannich Bases: Interaction with DNA
  59. 752 INHIBITION OF HEPATITS C VIRUS ENTRY BY A PLANT-DERIVED FLAVONE
  60. Antimalarial activities of ferroquine conjugates with either glutathione reductase inhibitors or glutathione depletors via a hydrolyzable amide linker
  61. Unsaturated Mannich Bases Active Against Multidrug-ResistantTrypanosoma brucei bruceiStrains
  62. A Sugar-Modified Phosphole Gold Complex with Antiproliferative Properties Acting as a Thioredoxin Reductase Inhibitor in MCF-7 Cells
  63. Antimalarial Dual Drugs Based on Potent Inhibitors of Glutathione Reductase fromPlasmodium falciparum
  64. The aza-analogues of 1,4-naphthoquinones are potent substrates and inhibitors of plasmodial thioredoxin and glutathione reductases and of human erythrocyte glutathione reductase
  65. Correction: Thioredoxin Glutathione Reductase from Schistosoma mansoni: An Essential Parasite Enzyme and a Key Drug Target
  66. Thioredoxin Glutathione Reductase from Schistosoma mansoni: An Essential Parasite Enzyme and a Key Drug Target
  67. Crystal Structure of human Glutathione Reductase complexed with a Fluoro-Analogue of the Menadione Derivative M5
  68. A Fluoro Analogue of the Menadione Derivative 6-[2‘-(3‘-Methyl)-1‘,4‘-naphthoquinolyl]hexanoic Acid Is a Suicide Substrate of Glutathione Reductase. Crystal Structure of the Alkylated Human Enzyme†
  69. Specific Inhibitors of Plasmodium falciparum Thioredoxin Reductase as Potential Antimalarial Agents.
  70. Crystal Structure Analysis of the human Glutahione Reductase, complexed with GoPI
  71. Specific inhibitors of Plasmodium falciparum thioredoxin reductase as potential antimalarial agents
  72. Gold(I)-Phosphinkomplexe für die irreversible Hemmung von humanen Disulfid-Reduktasen
  73. Undressing of Phosphine Gold(I) Complexes as Irreversible Inhibitors of Human Disulfide Reductases
  74. Irreversible Inactivation of Trypanothione Reductase by Unsaturated Mannich Bases:  A Divinyl Ketone as Key Intermediate
  75. Synthesis of 5-Nitro-2-furancarbohydrazides and Theircis-Diamminedichloroplatinum Complexes as Bitopic and Irreversible Human Thioredoxin Reductase Inhibitors
  76. Mechanistic Studies on a Novel, Highly Potent Gold-Phosphole Inhibitor of Human Glutathione Reductase
  77. 5-Substituted Tetrazoles as Bioisosteres of Carboxylic Acids. Bioisosterism and Mechanistic Studies on Glutathione Reductase Inhibitors as Antimalarials
  78. Screening of Plasmodium falciparum iron superoxide dismutase inhibitors and accuracy of the SOD-assays
  79. Mechanism-Based Inactivation of Thioredoxin Reductase fromPlasmodium falciparumby Mannich Bases. Implication for Cytotoxicity†
  80. Double-drug development against antioxidant enzymes fromPlasmodium falciparum
  81. Antitrypanosomal Activities and Cytotoxicity of 5-Nitro-2-furancarbohydrazides.
  82. A novel mechanism for inhibition of HIV-1 reverse transcriptase
  83. Antitrypanosomal activities and cytotoxicity of 5-nitro-2-furancarbohydrazides
  84. Comparison of the Inhibition of Human and Trypanosoma cruzi Prolyl Endopeptidases
  85. A Prodrug Form of aPlasmodium falciparumGlutathione Reductase Inhibitor Conjugated with a 4-Anilinoquinoline
  86. Trypanosoma cruzi Prolyl Oligopeptidase Tc80 Is Involved in Nonphagocytic Mammalian Cell Invasion by Trypomastigotes
  87. Bromination Studies of the 2,3-Dimethylnaphthazarin Core Allowing Easy Access to Naphthazarin Derivatives
  88. Antiplasmodial Activity and Cytotoxicity of Bis-, Tris-, and Tetraquinolines with Linear or Cyclic Amino Linkers
  89. Potent and specific inhibitors of trypanothione reductase from Trypanosoma cruzi
  90. 2- and 3-Substituted 1,4-Naphthoquinone Derivatives as Subversive Substrates of Trypanothione Reductase and Lipoamide Dehydrogenase fromTrypanosomacruzi:  Synthesis and Correlation between Redox Cycling Activities and in Vitro Cytotoxicity
  91. The conserved redox-sensitive cysteine residue of the DNA-binding region in the c-Rel protein is involved in the regulation of the phosphorylation of the protein
  92. The conserved redox-sensitive cysteine residue of the DNA-binding region in the c-Rel protein is involved in the regulation of the phosphorylation of the protein
  93. Antimalarial, Antitrypanosomal, and Antileishmanial Activities and Cytotoxicity of Bis(9-amino-6-chloro-2-methoxyacridines):  Influence of the Linker#
  94. Parallel synthesis of a library of 1,4-naphthoquinones and automated screening of potential inhibitors of trypanothione reductase from Trypanosoma cruzi
  95. Trypanothione reductase inhibition/trypanocidal activity relationships in a 1,4-bis(3-aminopropyl)piperazine series
  96. Synthesis of polyamine derivatives for the preparation of affinity chromatography columns for the search of new Trypanosoma cruzi targets
  97. Synthesis of 5,5′-Dithiobis(2-nitrobenzamides)as Alternative Substrates for Trypanothione Reductase and Thioredoxin Reductase: A Microtiter Colorimetric Assay for Inhibitor Screening
  98. Automated parallel synthesis of a tetrahydroisoquinolin-based library: Potential prolyl endopeptidase inhibitors
  99. Evidence for the co-existence of glutathione reductase and trypanothione reductase in the non-trypanosomatid Euglenozoa: Euglena gracilis Z
  100. 18-Vinyldeoxycorticosterone: a potent inhibitor of the bovine cytochrome P-45011β
  101. Photoaffinity labelling of the human mineralocorticoid receptor with steroids having a reactive group at position 3, 18 or 21
  102. Structure-activity relationships in 2-aminodiphenylsulfides against trypanothione reductase from Trypanosoma cruzi
  103. A General Approach to the Synthesis of Polyamine Linked-Monoindolylmaleimides, a New Series of Trypanothione Reductase Inhibitors.
  104. New spermine and spermidine derivatives as potent inhibitors of Trypanosoma cruzi Trypanothione Reductase
  105. Glutathione-dependent activities of Trypanosoma cruzi p52 makes it a new member of the thiol:disulphide oxidoreductase family
  106. New potent inhibitors of trypanothione reductase from Trypanosoma cruzi in the 2-aminodiphenylsulfide series
  107. New Steroidal Diazo Ketones as Potential Photoaffinity Labeling Reagents for the Mineralocorticoid Receptor:  Synthesis and Biological Activities
  108. The mineralocorticoid activity of progesterone derivatives depends on the nature of the C18 substituent.
  109. The mineralocorticoid activity of progesterone derivatives depends on the nature of the C18 substituent
  110. Synthesis of potential cytochrome P45011β-generated intermediates
  111. Purification of Microsomal Native Cytochrome b5 fromPotato Tubers (Solanum tuberosum L.)
  112. An improved synthesis of 18-norandrost-4-ene-3,17-dione
  113. High Sensitivity to Auxin is a Common Feature of Hairy Root
  114. Iridoid Glucosides and Phenylpropanoid Glycosides fromDeplanchea speciosa
  115. Epiallo-yohimbine derivatives isolated from in vitro hairy-root cultures of Catharanthus trichophyllus
  116. Production of indole alkaloids by in vitro root cultures from Catharanthus trichophyllus
  117. Iridoids ofRandia ruiziana
  118. Structure and Synthesis of Cucumopine, a New Crown Gall and Hairy-root Opine
  119. Cucumopine—a new T-DNA-encoded opine in hairy root and crown gall
  120. Iridoids of Guyanese Species of Stigmaphyllon