All Stories

  1. Transcriptional licensing is required for Pyrin inflammasome activation in human macrophages and bypassed by mutations causing familial Mediterranean fever

    Article • PLoS Biology, November 2022, PLOS

    Professor Eicke Latz

  2. NLRP3 inflammasome-activating arginine-based liposomes promote antigen presentations in dendritic cells

    Article • International Journal of Nanomedicine, May 2019, Dove Medical Press

    Professor Eicke Latz

  3. Recent insights into the molecular mechanisms of the NLRP3 inflammasome activation

    Article • F1000Research, June 2016, Faculty of 1000, Ltd.

    Dr Matthew SJ Mangan, Professor Eicke Latz

  4. Microbiota-Modulated Metabolites Shape the Intestinal Microenvironment by Regulating NLRP6 Inflammasome Signaling

    Article • Cell, December 2015, Elsevier

    Professor Eicke Latz

  5. Weekly Treatment of 2-Hydroxypropyl-β-cyclodextrin Improves Intracellular Cholesterol Levels in LDL Receptor Knockout Mice

    Article • International Journal of Molecular Sciences, September 2015, MDPI AG

    Professor Eicke Latz

  6. CX3CR1 is a gatekeeper for intestinal barrier integrity in mice: Limiting steatohepatitis by maintaining intestinal homeostasis

    Article • Hepatology, September 2015, Wiley

    Professor Eicke Latz

  7. Innate immune memory: a paradigm shift in understanding host defense

    Article • Nature Immunology, June 2015, Nature

    Professor Eicke Latz

  8. Neutrophil extracellular trap formation in supragingival biofilms

    Article • International Journal of Medical Microbiology, June 2015, Elsevier

    Professor Eicke Latz

  9. Neuroinflammation in Alzheimer's disease

    Article • The Lancet Neurology, April 2015, Elsevier

    Professor Eicke Latz

  10. Light induces NLRP3 inflammasome activation in retinal pigment epithelial cells via lipofuscin-mediated photooxidative damage

    Article • Journal of Molecular Medicine, March 2015, Springer Science + Business Media

    Professor Eicke Latz

  11. Innate immunity in Alzheimer's disease

    Article • Nature Immunology, February 2015, Nature

    Professor Eicke Latz

  12. A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases

    Article • Nature Medicine, February 2015, Nature

    Professor Eicke Latz, Dr Mark S Butler

  13. Synergistic activation of Toll-like receptor 8 by two RNA degradation products

    Article • Nature Structural & Molecular Biology, February 2015, Nature

    Professor Eicke Latz

  14. A transcriptional perspective on human macrophage biology

    Article • Seminars in Immunology, February 2015, Elsevier

    Professor Eicke Latz

  15. The Inflammasomes and Autoinflammatory Syndromes

    Article • Annual Review of Pathology Mechanisms of Disease, January 2015, Annual Reviews

    Professor Eicke Latz, Dr Bernardo S Franklin, Dr Dominic De Nardo

  16. NLRP3 Protein Deficiency Exacerbates Hyperoxia-induced Lethality through Stat3 Protein Signaling Independent of Interleukin-1β

    Article • Journal of Biological Chemistry, December 2014, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Eicke Latz

  17. S-14

    Article • Cytokine, November 2014, Elsevier

    Professor Eicke Latz

  18. 176

    Article • Cytokine, November 2014, Elsevier

    Professor Eicke Latz

  19. 36

    Article • Cytokine, November 2014, Elsevier

    Professor Eicke Latz

  20. 9

    Article • Cytokine, November 2014, Elsevier

    Professor Eicke Latz

  21. 177

    Article • Cytokine, November 2014, Elsevier

    Professor Eicke Latz

  22. 146

    Article • Cytokine, November 2014, Elsevier

    Professor Eicke Latz

  23. 30

    Article • Cytokine, November 2014, Elsevier

    Professor Eicke Latz

  24. Editorial overview: Special section: Effects of endogenous immune stimulants: From a defence system against infection to a homeostatic mechanism linking metabolism with inflammation

    Article • Current Opinion in Immunology, October 2014, Elsevier

    Professor Eicke Latz

  25. Inflammasome activation in response to dead cells and their metabolites

    Article • Current Opinion in Immunology, October 2014, Elsevier

    Professor Eicke Latz

  26. OutKnocker: a web tool for rapid and simple genotyping of designer nuclease edited cell lines

    Article • Genome Research, September 2014, Cold Spring Harbor Laboratory Press

    Professor Eicke Latz

  27. LOX-1 and mitochondria: an inflammatory relationship

    Article • Cardiovascular Research, August 2014, European Society of Cardiology

    Professor Eicke Latz

  28. Innate immune activation in neurodegenerative disease

    Article • Nature Reviews Immunology, June 2014, Nature

    Professor Eicke Latz

  29. The adaptor ASC has extracellular and 'prionoid' activities that propagate inflammation

    Article • Nature Immunology, June 2014, Nature

    Professor Eicke Latz, Dr Bernardo S Franklin, Dr Dominic De Nardo

  30. Gadolinium-based compounds induce NLRP3-dependent IL-1β production and peritoneal inflammation

    Article • Annals of the Rheumatic Diseases, June 2014, BMJ

    Professor Eicke Latz

  31. NLRC3 Puts the Brakes on STING

    Article • Immunity, March 2014, Elsevier

    Professor Eicke Latz

  32. Transcriptome-Based Network Analysis Reveals a Spectrum Model of Human Macrophage Activation

    Article • Immunity, February 2014, Elsevier

    Professor Eicke Latz, Dr Dominic De Nardo

  33. Mechanisms of Sterile Inflammation

    Article • January 2014

    Professor Eicke Latz

  34. New Insights into Mechanisms Controlling the NLRP3 Inflammasome and Its Role in Lung Disease

    Article • American Journal Of Pathology, January 2014, Elsevier

    Professor Eicke Latz, Dr Dominic De Nardo

  35. Dual Engagement of the NLRP3 and AIM2 Inflammasomes by Plasmodium-Derived Hemozoin and DNA during Malaria

    Article • Cell Reports, January 2014, Elsevier

    Professor Eicke Latz

  36. High-density lipoprotein mediates anti-inflammatory reprogramming of macrophages via the transcriptional regulator ATF3

    Article • Nature Immunology, December 2013, Springer Science + Business Media

    Professor Bryan R. G. Williams, Professor Eicke Latz, Dr Dominic De Nardo

  37. Cell intrinsic immunity spreads to bystander cells via the intercellular transfer of cGAMP

    Article • Nature, September 2013, Nature

    Professor Eicke Latz

  38. HIV-1 Induces the First Signal to Activate the NLRP3 Inflammasome in Monocyte-Derived Macrophages

    Article • Intervirology, September 2013, Karger Publishers

    Professor Eicke Latz, Professor Juan C. Hernandez, Professor Juan C. Hernandez

  39. 197

    Article • Cytokine, September 2013, Elsevier

    Professor Eicke Latz

  40. 63

    Article • Cytokine, September 2013, Elsevier

    Professor Eicke Latz

  41. IRF5, IRF8, and IRF7 in human pDCs - the good, the bad, and the insignificant?

    Article • European Journal of Immunology, July 2013, Wiley

    Professor Eicke Latz

  42. CD36 coordinates NLRP3 inflammasome activation by facilitating intracellular nucleation of soluble ligands into particulate ligands in sterile inflammation

    Article • Nature Immunology, June 2013, Nature

    Professor Eicke Latz

  43. Chemical genetics reveals a kinase-independent role for protein kinase R in pyroptosis

    Article • Nature Methods, June 2013, Nature

    Professor Eicke Latz

  44. Activation of the NLRP3 Inflammasome by IAV Virulence Protein PB1-F2 Contributes to Severe Pathophysiology and Disease

    Article • PLoS Pathogens, May 2013, PLOS

    Professor Eicke Latz

  45. Activation and regulation of the inflammasomes

    Article • Nature Reviews Immunology, May 2013, Nature

    Professor Eicke Latz

  46. Chemical genetics reveals a kinase-independent role for protein kinase R in pyroptosis

    Article • Nature Methods, April 2013, Nature

    Professor Eicke Latz

  47. Cholesterol Crystals and Inflammation

    Article • Current Rheumatology Reports, February 2013, Springer Science + Business Media

    Professor Eicke Latz

  48. iGLuc: a luciferase-based inflammasome and protease activity reporter

    Article • Nature Methods, January 2013, Nature

    Professor Eicke Latz

  49. The Inflammasome

    Article • January 2013

    Professor Eicke Latz

  50. Mechanisms of Sterile Inflammation

    Article • Frontiers in Immunology, January 2013, Frontiers

    Professor Eicke Latz

  51. Assessment and Quantification of Crystal-Induced Lysosomal Damage

    Article • January 2013, Springer Science + Business Media

    Professor Eicke Latz

  52. ASC Speck Formation as a Readout for Inflammasome Activation

    Article • January 2013, Springer Science + Business Media

    Professor Eicke Latz

  53. NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice

    Article • Nature, December 2012, Nature

    Professor Eicke Latz

  54. Noncanonical Autophagy Is Required for Type I Interferon Secretion in Response to DNA-Immune Complexes

    Article • Immunity, December 2012, Elsevier

    Professor Eicke Latz

  55. Complement dependency of cholesterol crystal-induced inflammation – I. Pathway activation mechanisms, cytokine responses and endothelial cell activation

    Article • Immunobiology, November 2012, Elsevier

    Professor Eicke Latz

  56. Complement dependency of cholesterol crystal-induced inflammation – II. Inflammasome activation and regulation mechanisms involving reconstituted high density lipoprotein (HDL) and C-reactive protein (CRP)

    Article • Immunobiology, November 2012, Elsevier

    Professor Eicke Latz

  57. HIV Type 1 Infection Up-Regulates TLR2 and TLR4 Expression and Function in Vivo and in Vitro

    Article • AIDS Research and Human Retroviruses, October 2012, Mary Ann Liebert Inc

    Professor Eicke Latz, Professor Juan C. Hernandez, Professor Juan C. Hernandez

  58. PKR stirs up inflammasomes

    Article • Cell Research, September 2012, Nature

    Professor Eicke Latz

  59. Inflammasomopathies: Diseases Linked to the NLRP3 Inflammasome

    Article • July 2012, World Scientific Pub Co Pte Lt

    Professor Eicke Latz, Dr Dominic De Nardo

  60. IL-1, quo vadis?

    Article • Atherosclerosis, June 2012, Elsevier

    Professor Eicke Latz

  61. For gut's sake: NLRC4 inflammasomes distinguish friend from foe

    Article • Nature Immunology, April 2012, Nature

    Professor Eicke Latz, Dr Bernardo S Franklin

  62. Structures of the HIN Domain:DNA Complexes Reveal Ligand Binding and Activation Mechanisms of the AIM2 Inflammasome and IFI16 Receptor

    Article • Immunity, April 2012, Elsevier

    Professor Eicke Latz, Dr. Jiansheng Jiang

  63. NUCLEOTIDE-BINDING OLIGOMERIZATION DOMAIN-LIKE RECEPTOR 3 IS CRITICAL IN VASCULAR REPAIR

    Article • Journal of the American College of Cardiology, March 2012, Elsevier

    Professor Eicke Latz

  64. Direct measurement of the interaction force between immunostimulatory CpG-DNA and TLR9 fusion protein

    Article • Journal of Molecular Recognition, January 2012, Wiley

    Professor Eicke Latz

  65. Up-Regulation of TLR2 and TLR4 in Dendritic Cells in Response to HIV Type 1 and Coinfection with Opportunistic Pathogens

    Article • AIDS Research and Human Retroviruses, October 2011, Mary Ann Liebert Inc

    Professor Eicke Latz, Professor Juan C. Hernandez, Professor Juan C. Hernandez

  66. Intracellular sensing of microbes and danger signals by the inflammasomes

    Article • Immunological Reviews, August 2011, Wiley

    Professor Eicke Latz

  67. NLRP3 inflammasomes link inflammation and metabolic disease

    Article • Trends in Immunology, August 2011, Elsevier

    Professor Eicke Latz, Dr Dominic De Nardo

  68. Critical role of nucleotide-binding oligomerization domain-like receptor 3 in vascular repair

    Article • Biochemical and Biophysical Research Communications, August 2011, Elsevier

    Professor Eicke Latz

  69. Getting Closer to the Dirty Little Secret

    Article • Immunity, April 2011, Elsevier

    Professor Eicke Latz

  70. Activation and Regulation of the NLRP3 Inflammasome

    Article • January 2011, Springer Science + Business Media

    Professor Eicke Latz

  71. Innate Immune Receptors for Nucleic Acids

    Article • January 2011, Springer Science + Business Media

    Professor Eicke Latz

  72. IFI16 is an innate immune sensor for intracellular DNA

    Article • Nature Immunology, October 2010, Nature

    Professor Eicke Latz

  73. The Rab11a GTPase Controls Toll-like Receptor 4-Induced Activation of Interferon Regulatory Factor-3 on Phagosomes

    Article • Immunity, October 2010, Elsevier

    Professor Eicke Latz

  74. NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

    Article • Nature, July 2010, Nature

    Professor Eicke Latz

  75. Alternating 2′-O-ribose methylation is a universal approach for generating non-stimulatory siRNA by acting as TLR7 antagonist

    Article • Immunobiology, July 2010, Elsevier

    Professor Tim D Sparwasser, Professor Eicke Latz

  76. Higher order structure of short immunostimulatory oligonucleotides studied by atomic force microscopy

    Article • Ultramicroscopy, May 2010, Elsevier

    Professor Eicke Latz

  77. NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

    Article • Nature, April 2010, Nature

    Professor Eicke Latz

  78. Rational Design of Immunostimulatory siRNAs

    Article • April 2010, Elsevier

    Professor Bryan R. G. Williams, Professor Eicke Latz

  79. Phosphothioate oligodeoxynucleotides inhibitPlasmodiumsporozoite gliding motility

    Article • Cellular Microbiology, April 2010, Wiley

    Professor Eicke Latz

  80. The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses

    Article • Nature Immunology, March 2010, Nature

    Professor Eicke Latz

  81. Listeria monocytogenes is sensed by the NLRP3 and AIM2 inflammasome

    Article • European Journal of Immunology, March 2010, Wiley

    Professor Eicke Latz

  82. Critical functions of priming and lysosomal damage for NLRP3 activation

    Article • European Journal of Immunology, March 2010, Wiley

    Professor Eicke Latz

  83. The Sterile Inflammatory Response

    Article • Annual Review of Immunology, March 2010, Annual Reviews

    Professor Eicke Latz

  84. The inflammasomes: mechanisms of activation and function

    Article • Current Opinion in Immunology, February 2010, Elsevier

    Professor Eicke Latz

  85. Intracellular DNA recognition

    Article • Nature Reviews Immunology, February 2010, Nature

    Professor Eicke Latz

  86. Influence of genetic variations in TLR4 and TIRAP/Mal on the course of sepsis and pneumonia and cytokine release: an observational study in three cohorts

    Article • Critical Care, January 2010, Springer Science + Business Media

    Professor Eicke Latz

  87. Inflammasomes: too big to miss

    Article • Journal of Clinical Investigation, December 2009, American Society for Clinical Investigation

    Professor Eicke Latz

  88. RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III–transcribed RNA intermediate

    Article • Nature Immunology, July 2009, Nature

    Professor Eicke Latz

  89. Recognition of 5′ Triphosphate by RIG-I Helicase Requires Short Blunt Double-Stranded RNA as Contained in Panhandle of Negative-Strand Virus

    Article • Immunity, July 2009, Elsevier

    Professor Eicke Latz, Osamu Takeuchi

  90. AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC

    Article • Nature, January 2009, Nature

    Professor Eicke Latz

  91. 'Toll2008' outgrows its name

    Article • Nature Immunology, January 2009, Nature

    Professor Eicke Latz

  92. Toll-Like Receptor Interactions Imaged by FRET Microscopy and GFP Fragment Reconstitution

    Article • January 2009, Springer Science + Business Media

    Professor Eicke Latz

  93. TLR-Independent Type I Interferon Induction in Response to an Extracellular Bacterial Pathogen via Intracellular Recognition of Its DNA

    Article • Cell Host & Microbe, December 2008, Elsevier

    Professor Eicke Latz

  94. Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

    Article • Nature Immunology, July 2008, Nature

    Professor Eicke Latz

  95. The NALP3 inflammasome is involved in the innate immune response to amyloid-β

    Article • Nature Immunology, July 2008, Nature

    Professor Eicke Latz

  96. SPTLC1 Binds ABCA1 To Negatively Regulate Trafficking and Cholesterol Efflux Activity of the Transporter †

    Article • Biochemistry, June 2008, American Chemical Society (ACS)

    Professor Eicke Latz

  97. Efficacy and Safety of Chaperonin 10 in Patients With Moderate to Severe Plaque Psoriasis: Evidence of Utility Beyond a Single Indication

    Article • Archives of Dermatology, May 2008, American Medical Association (AMA)

    Professor Eicke Latz

  98. The DNA Sugar Backbone 2′ Deoxyribose Determines Toll-like Receptor 9 Activation

    Article • Immunity, March 2008, Elsevier

    Professor Eicke Latz

  99. Corrigendum: Ligand-induced conformational changes allosterically activate Toll-like receptor 9

    Article • Nature Immunology, November 2007, Nature

    Professor Eicke Latz

  100. Corrigendum: Toll-like receptor 9—dependent activation by DNA-containing immune complexes is mediated by HMGB1 and RAGE

    Article • Nature Immunology, July 2007, Nature

    Professor Eicke Latz

  101. Ligand-induced conformational changes allosterically activate Toll-like receptor 9

    Article • Nature Immunology, June 2007, Nature

    Professor Eicke Latz

  102. Toll-like receptor 9–dependent activation by DNA-containing immune complexes is mediated by HMGB1 and RAGE

    Article • Nature Immunology, April 2007, Nature

    Professor Eicke Latz

  103. HMGB1 SIGNALS THROUGH TOLL-LIKE RECEPTOR (TLR) 4 AND TLR2

    Article • Shock, August 2006, Wolters Kluwer Health

    Professor Eicke Latz

  104. Endocytic pathways regulate Toll-like receptor 4 signaling and link innate and adaptive immunity

    Article • The EMBO Journal, February 2006, Wiley

    Professor Eicke Latz

  105. Human lupus autoantibody–DNA complexes activate DCs through cooperation of CD32 and TLR9

    Article • Journal of Clinical Investigation, January 2005, American Society for Clinical Investigation

    Professor Eicke Latz

  106. Human lupus autoantibody–DNA complexes activate DCs through cooperation of CD32 and TLR9

    Article • Journal of Clinical Investigation, January 2005, American Society for Clinical Investigation

    Professor Eicke Latz

  107. Mechanisms of TLR9 activation

    Article • Journal of Endotoxin Research, December 2004, SAGE Publications

    Professor Eicke Latz

  108. TLR9 signals after translocating from the ER to CpG DNA in the lysosome

    Article • Nature Immunology, January 2004, Nature

    Professor Eicke Latz

  109. The LPS receptor generates inflammatory signals from the cell surface

    Article • Journal of Endotoxin Research, December 2003, SAGE Publications

    Professor Eicke Latz

  110. Receptor “cross talk” in innate immunity

    Article • Journal of Clinical Investigation, October 2003, American Society for Clinical Investigation

    Professor Eicke Latz

  111. Receptor “cross talk” in innate immunity

    Article • Journal of Clinical Investigation, October 2003, American Society for Clinical Investigation

    Professor Eicke Latz

  112. Lysines 128 and 132 Enable Lipopolysaccharide Binding to MD-2, Leading to Toll-like Receptor-4 Aggregation and Signal Transduction

    Article • Journal of Biological Chemistry, September 2003, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Eicke Latz

  113. Pentoxifyllin Attenuates the Systemic Inflammatory Response Induced During Isolated Limb Perfusion With Recombinant Human Tumor Necrosis Factor-? and Melphalan

    Article • Annals of Surgical Oncology, June 2003, Springer Science + Business Media

    Professor Eicke Latz

  114. IKKε and TBK1 are essential components of the IRF3 signaling pathway

    Article • Nature Immunology, April 2003, Nature

    Professor Eicke Latz

  115. Cell Distributions and Functions of Toll-like Receptor 4 Studied by Fluorescent Gene Constructs

    Article • Scandinavian Journal of Infectious Diseases, January 2003, Taylor & Francis

    Professor Eicke Latz

  116. Toll-like receptor 9 and systemic autoimmune diseases

    Article • Springer Science + Business Media

    Professor Eicke Latz