All Stories

  1. Identification of a histone family gene signature for predicting the prognosis of cervical cancer patients

    Article • Scientific Reports, November 2017, Nature

    Professor Bryan R. G. Williams

  2. (−)-Epigallocatechin-3-gallate and EZH2 inhibitor GSK343 have similar inhibitory effects and mechanisms of action on colorectal cancer cells

    Article • Clinical and Experimental Pharmacology and Physiology, November 2017, Wiley

    Professor Bryan R. G. Williams, Dr. Le Ying

  3. Understanding immune phenotypes in human gastric disease tissues by multiplexed immunohistochemistry

    Article • Journal of Translational Medicine, October 2017, Springer Science + Business Media

    Professor Bryan R. G. Williams, Dr. Le Ying

  4. Topoisomerase 1 Inhibition Promotes Cyclic GMP-AMP Synthase-Dependent Antiviral Responses

    Article • mBio, October 2017, ASM Journals

    Professor Bryan R. G. Williams

  5. (-)-Epigallocatechin-3-gallate and atorvastatin treatment down-regulates liver fibrosis-related genes in non-alcoholic fatty liver disease

    Article • Clinical and Experimental Pharmacology and Physiology, October 2017, Wiley

    Professor Bryan R. G. Williams, Dr. Le Ying

  6. An Emergence Framework of Carcinogenesis

    Article • Frontiers in Oncology, September 2017, Frontiers

    Professor Bryan R. G. Williams

  7. The innate immune receptor MDA5 limits rotavirus infection but promotes cell death and pancreatic inflammation

    Article • The EMBO Journal, August 2017, EMBO

    Professor Bryan R. G. Williams

  8. Integrin-Linked Kinase Expression in Myeloid Cells Promotes Inflammatory Signaling during Experimental Colitis

    Article • The Journal of Immunology, August 2017, The American Association of Immunologists

    Professor Bryan R. G. Williams

  9. ATF3 Repression of BCL-X L Determines Apoptotic Sensitivity to HDAC Inhibitors across Tumor Types

    Article • Clinical Cancer Research, June 2017, American Association for Cancer Research (AACR)

    Professor Bryan R. G. Williams

  10. Auto-phosphorylation Represses Protein Kinase R Activity

    Article • Scientific Reports, March 2017, Nature

    Professor Bryan R. G. Williams

  11. A non‐canonical function of Ezh2 preserves immune homeostasis

    Article • EMBO Reports, February 2017, EMBO

    Professor Bryan R. G. Williams

  12. Activation of cGAS-dependent antiviral responses by DNA intercalating agents

    Article • Nucleic Acids Research, September 2016, Oxford University Press (OUP)

    Professor Bryan R. G. Williams

  13. Activating Transcription Factor 3 Expression as a Marker of Response to the Histone Deacetylase Inhibitor Pracinostat

    Article • Molecular Cancer Therapeutics, April 2016, American Association for Cancer Research (AACR)

    Professor Bryan R. G. Williams

  14. Surgical margins in head and neck squamous cell carcinoma: Effect of heat artifact on immunohistochemistry as a future tool for assessment

    Article • Head & Neck, April 2016, Wiley

    Professor Bryan R. G. Williams

  15. Transcriptional Activation of Inflammatory Genes: Mechanistic Insight into Selectivity and Diversity

    Article • Biomolecules, November 2015, MDPI AG

    Professor Bryan R. G. Williams

  16. Telomerase Deficiency Causes Alveolar Stem Cell Senescence-associated Low-grade Inflammation in Lungs

    Article • Journal of Biological Chemistry, October 2015, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Bryan R. G. Williams

  17. The protein activator of protein kinase R, PACT/RAX, negatively regulates protein kinase R during mouse anterior pituitary development

    Article • FEBS Journal, October 2015, Wiley

    Professor Bryan R. G. Williams

  18. The acetyltransferase HAT1 moderates the NF-κB response by regulating the transcription factor PLZF

    Article • Nature Communications, April 2015, Springer Science + Business Media

    Professor Bryan R. G. Williams

  19. BTB-ZF transcriptional regulator PLZF modifies chromatin to restrain inflammatory signaling programs

    Article • Proceedings of the National Academy of Sciences, January 2015, Proceedings of the National Academy of Sciences

    Professor Bryan R. G. Williams

  20. Sequence-dependent off-target inhibition of TLR7/8 sensing by synthetic microRNA inhibitors

    Article • Nucleic Acids Research, December 2014, Oxford University Press (OUP)

    Professor Bryan R. G. Williams, Samuel Forster

  21. Molecular dynamics reveal a novel kinase-substrate interface that regulates protein translation

    Article • Journal of Molecular Cell Biology, November 2014, Oxford University Press (OUP)

    Professor Bryan R. G. Williams

  22. IL-10 regulates Aicda expression through miR-155

    Article • Journal of Leukocyte Biology, November 2014, Society for Leukocyte Biology

    Professor Bryan R. G. Williams

  23. Integrin-linked Kinase Modulates Lipopolysaccharide- and Helicobacter pylori -induced Nuclear Factor κB-activated Tumor Necrosis Factor-α Production via Regulation of p65 Serine 536 Phosphorylation

    Article • Journal of Biological Chemistry, August 2014, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Bryan R. G. Williams

  24. Protein Kinase R and the Inflammasome

    Article • Journal of Interferon & Cytokine Research, June 2014, Mary Ann Liebert Inc

    Professor Bryan R. G. Williams

  25. The Role of Ets2 Transcription Factor in the Induction of MicroRNA-155 (miR-155) by Lipopolysaccharide and Its Targeting by Interleukin-10

    Article • Journal of Biological Chemistry, December 2013, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Bryan R. G. Williams

  26. High-density lipoprotein mediates anti-inflammatory reprogramming of macrophages via the transcriptional regulator ATF3

    Article • Nature Immunology, December 2013, Springer Science + Business Media

    Professor Bryan R. G. Williams, Professor Eicke Latz, Dr Dominic De Nardo

  27. Inosine Modulation of TLR7/8 Sensing

    Article • Journal of Virology, November 2013, ASM Journals

    Michael Gantier, Professor Bryan R. G. Williams

  28. Activating Transcription Factor 3 Contributes to Toll-Like Receptor-Mediated Macrophage Survival via Repression ofBaxandBak

    Article • Journal of Interferon & Cytokine Research, November 2013, Mary Ann Liebert Inc

    Professor Bryan R. G. Williams

  29. Allan S.Y. Lau (1952–2013) A Dedicated Interferon and Cytokine Biologist and Infectious Disease Physician

    Article • Journal of Interferon & Cytokine Research, August 2013, Mary Ann Liebert Inc

    Professor Bryan R. G. Williams

  30. Fine tuning type I interferon responses

    Article • Cytokine & Growth Factor Reviews, June 2013, Elsevier

    Professor Bryan R. G. Williams

  31. The use of miRNA microarrays for the analysis of cancer samples with global miRNA decrease

    Article • RNA, May 2013, Cold Spring Harbor Laboratory Press

    Professor Bryan R. G. Williams

  32. ATF3 Suppresses Metastasis of Bladder Cancer by Regulating Gelsolin-Mediated Remodeling of the Actin Cytoskeleton

    Article • Cancer Research, March 2013, American Association for Cancer Research (AACR)

    Professor Bryan R. G. Williams

  33. Conformational rearrangements of RIG-I receptor on formation of a multiprotein:dsRNA assembly

    Article • Nucleic Acids Research, January 2013, Oxford University Press (OUP)

    Professor Bryan R. G. Williams

  34. Regulation of Double-Stranded RNA Dependent Protein Kinase Expression and Attenuation of Protein Synthesis Induced by Bacterial Toll-Like Receptors Agonists in the Absence of Interferon

    Article • Journal of Interferon & Cytokine Research, October 2012, Mary Ann Liebert Inc

    Professor Bryan R. G. Williams

  35. Human Toll-Like Receptor 8 Can Be Cool Too: Implications for Foreign RNA Sensing

    Article • Journal of Interferon & Cytokine Research, August 2012, Mary Ann Liebert Inc

    Professor Bryan R. G. Williams

  36. A miR-19 regulon that controls NF- B signaling

    Article • Nucleic Acids Research, June 2012, Oxford University Press (OUP)

    Professor Bryan R. G. Williams

  37. Regulation of Actin Dynamics by Protein Kinase R Control of Gelsolin Enforces Basal Innate Immune Defense

    Article • Immunity, May 2012, Elsevier

    Professor Bryan R. G. Williams

  38. The Promyelocytic Leukemia Zinc Finger Protein: Two Decades of Molecular Oncology

    Article • Frontiers in Oncology, January 2012, Frontiers

    Professor Bryan R. G. Williams

  39. HDACi: molecular mechanisms and therapeutic implications in the innate immune system

    Article • Immunology and Cell Biology, November 2011, Wiley

    Professor Bryan R. G. Williams

  40. Dynamiting Viruses with MxA

    Article • Immunity, October 2011, Elsevier

    Professor Bryan R. G. Williams

  41. Making Sense of Viral RNA Sensing

    Article • September 2011, Elsevier

    Professor Bryan R. G. Williams

  42. Analysis of microRNA turnover in mammalian cells following Dicer1 ablation

    Article • Nucleic Acids Research, March 2011, Oxford University Press (OUP)

    Professor Bryan R. G. Williams

  43. siRNA‐induced immunostimulation through TLR7 promotes antitumoral activity against HPV‐driven tumors in vivo

    Article • Immunology and Cell Biology, March 2011, Wiley

    Professor Bryan R. G. Williams

  44. Different modes of interaction by TIAR and HuR with target RNA and DNA

    Article • Nucleic Acids Research, January 2011, Oxford University Press (OUP)

    Professor Bryan R. G. Williams

  45. Interferon-Stimulated Genes and Their Protein Products: What and How?

    Article • Journal of Interferon & Cytokine Research, January 2011, Mary Ann Liebert Inc

    Professor Bryan R. G. Williams

  46. Differentiating the interferon pathway

    Article • Cell Cycle, September 2010, Taylor & Francis

    Professor Bryan R. G. Williams

  47. Genetic modulation of TLR8 response following bacterial phagocytosis

    Article • Human Mutation, July 2010, Wiley

    Professor Bryan R. G. Williams

  48. Tumor Cell Response to Synchrotron Microbeam Radiation Therapy Differs Markedly From Cells in Normal Tissues

    Article • International Journal of Radiation Oncology*Biology*Physics, July 2010, Elsevier

    Professor Bryan R. G. Williams

  49. Role of PKR and Type I IFNs in Viral Control during Primary and Secondary Infection

    Article • PLoS Pathogens, June 2010, PLOS

    Professor Bryan R. G. Williams

  50. X4 and R5 HIV-1 have distinct post-entry requirements for uracil DNA glycosylase during infection of primary cells

    Article • Journal of Biological Chemistry, April 2010, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Bryan R. G. Williams

  51. Viral apoptosis is induced by IRF-3-mediated activation of Bax

    Article • The EMBO Journal, April 2010, Wiley

    Professor Bryan R. G. Williams

  52. Rational Design of Immunostimulatory siRNAs

    Article • April 2010, Elsevier

    Professor Bryan R. G. Williams, Professor Eicke Latz

  53. Monitoring Innate Immune Recruitment by siRNAs in Mammalian Cells

    Article • January 2010, Springer Science + Business Media

    Professor Bryan R. G. Williams

  54. siRNA delivery not Toll-free

    Article • Nature Biotechnology, October 2009, Springer Science + Business Media

    Professor Bryan R. G. Williams

  55. Modified vaccinia virus Ankara can activate NF-κB transcription factors through a double-stranded RNA-activated protein kinase (PKR)-dependent pathway during the early phase of virus replication

    Article • Virology, September 2009, Elsevier

    Professor Bryan R. G. Williams

  56. ATF3 transcription factor and its emerging roles in immunity and cancer

    Article • Journal of Molecular Medicine, August 2009, Springer Science + Business Media

    Professor Bryan R. G. Williams

  57. Promyelocytic Leukemia Zinc Finger Protein Regulates Interferon-Mediated Innate Immunity

    Article • Immunity, June 2009, Elsevier

    Professor Bryan R. G. Williams

  58. Latest advances in innate antiviral defence

    Article • F1000 Biology Reports, March 2009, F1000Research

    Professor Bryan R. G. Williams

  59. An Antiviral Response Directed by PKR Phosphorylation of the RNA Helicase A

    Article • PLoS Pathogens, February 2009, PLOS

    Professor Bryan R. G. Williams

  60. Differential Expression in Clear Cell Renal Cell Carcinoma Identified by Gene Expression Profiling

    Article • The Journal of Urology, February 2009, Elsevier

    Professor Bryan R. G. Williams

  61. Regulation of CRABP-II expression by MycN in Wilms tumor

    Article • Experimental Cell Research, December 2008, Elsevier

    Professor Bryan R. G. Williams

  62. The p59 oligoadenylate synthetase-like protein possesses antiviral activity that requires the C-terminal ubiquitin-like domain

    Article • Journal of General Virology, October 2008, Society for General Microbiology

    Professor Bryan R. G. Williams

  63. The Role of PACT in Mediating Gene Induction, PKR Activation, and Apoptosis in Response to Diverse Stimuli

    Article • Journal of Interferon & Cytokine Research, August 2008, Mary Ann Liebert Inc

    Professor Bryan R. G. Williams

  64. Protein Kinase R-dependent Regulation of Interleukin-10 in Response to Double-stranded RNA

    Article • Journal of Biological Chemistry, July 2008, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Bryan R. G. Williams

  65. Interferon-inducible antiviral effectors

    Article • Nature Reviews Immunology, July 2008, Springer Science + Business Media

    Professor Bryan R. G. Williams

  66. Determinants of Cytokine Induction by Small Interfering RNA in Human Peripheral Blood Mononuclear Cells

    Article • Journal of Interferon & Cytokine Research, April 2008, Mary Ann Liebert Inc

    Professor Bryan R. G. Williams

  67. TLR7 Is Involved in Sequence-Specific Sensing of Single-Stranded RNAs in Human Macrophages

    Article • The Journal of Immunology, February 2008, The American Association of Immunologists

    Professor Bryan R. G. Williams

  68. Quercetin Ingestion Does Not Alter Cytokine Changes in Athletes Competing in the Western States Endurance Run

    Article • Journal of Interferon & Cytokine Research, December 2007, Mary Ann Liebert Inc

    Professor Bryan R. G. Williams

  69. Human Immunodeficiency Virus-1/Surface Glycoprotein 120 Induces Apoptosis through RNA-Activated Protein Kinase Signaling in Neurons

    Article • Journal of Neuroscience, October 2007, Society for Neuroscience

    Professor Bryan R. G. Williams

  70. Interferons induce an antiviral state in human pancreatic islet cells

    Article • Virology, October 2007, Elsevier

    Professor Bryan R. G. Williams

  71. The response of mammalian cells to double-stranded RNA

    Article • Cytokine & Growth Factor Reviews, October 2007, Elsevier

    Professor Bryan R. G. Williams

  72. Negative Regulation of TLR-Signaling Pathways by Activating Transcription Factor-3

    Article • The Journal of Immunology, September 2007, The American Association of Immunologists

    Professor Bryan R. G. Williams

  73. Novel interferon- -induced gene expression in peripheral blood cells

    Article • Journal of Leukocyte Biology, July 2007, Society for Leukocyte Biology

    Professor Bryan R. G. Williams

  74. Fine‐tuning of the innate immune response by microRNAs

    Article • Immunology and Cell Biology, July 2007, Wiley

    Professor Bryan R. G. Williams

  75. Tissue-Specific and Inducer-Specific Differential Induction of ISG56 and ISG54 in Mice

    Article • Journal of Virology, June 2007, ASM Journals

    Professor Bryan R. G. Williams

  76. Reduced expression of autotaxin predicts survival in uveal melanoma

    Article • British Journal of Ophthalmology, May 2007, BMJ

    Professor Bryan R. G. Williams

  77. Oligoadenylate Synthetase/Protein Kinase R Pathways and αβ TCR+ T Cells Are Required for Adenovirus Vector: IFN-γ Inhibition of Herpes Simplex Virus-1 in Cornea

    Article • The Journal of Immunology, April 2007, The American Association of Immunologists

    Professor Bryan R. G. Williams

  78. Gene Modulatory Effects, Pharmacokinetics, and Clinical Tolerance of Interferon-α1b: A Second Member of the Interferon-α Family

    Article • Clinical Pharmacology & Therapeutics, March 2007, Springer Science + Business Media

    Professor Bryan R. G. Williams

  79. Salicylates Trigger Protein Synthesis Inhibition in a Protein Kinase R-like Endoplasmic Reticulum Kinase-dependent Manner

    Article • Journal of Biological Chemistry, February 2007, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Bryan R. G. Williams

  80. Type I Interferon Inhibits Antibody Responses Induced by a Chimpanzee Adenovirus Vector

    Article • Molecular Therapy, February 2007, Elsevier

    Professor Bryan R. G. Williams

  81. Lysophosphatidic acid downregulates tissue inhibitor of metalloproteinases, which are negatively involved in lysophosphatidic acid-induced cell invasion

    Article • Oncogene, November 2006, Springer Science + Business Media

    Professor Bryan R. G. Williams

  82. Cystic Fibrosis and Normal Human Airway Epithelial Cell Response to Influenza A Viral Infection.

    Article • Journal of Interferon & Cytokine Research, September 2006, Mary Ann Liebert Inc

    Professor Bryan R. G. Williams, Western Research Chair in Viral Pathogenesis Miguel Quinones-Mateu

  83. Cellular Retinoic Acid-Binding Protein II Is a Direct Transcriptional Target of MycN in Neuroblastoma

    Article • Cancer Research, August 2006, American Association for Cancer Research (AACR)

    Professor Bryan R. G. Williams

  84. Replication of Hepatitis C Virus (HCV) RNA in Mouse Embryonic Fibroblasts: Protein Kinase R (PKR)-Dependent and PKR-Independent Mechanisms for Controlling HCV RNA Replication and Mediating Interferon Activities

    Article • Journal of Virology, August 2006, ASM Journals

    Professor Bryan R. G. Williams

  85. Functional Annotation of IFN- α -Stimulated Gene Expression Profiles from Sensitive and Resistant Renal Cell Carcinoma Cell Lines

    Article • Journal of Interferon & Cytokine Research, August 2006, Mary Ann Liebert Inc

    Professor Bryan R. G. Williams

  86. PKR and RNase L Contribute to Protection against Lethal West Nile Virus Infection by Controlling Early Viral Spread in the Periphery and Replication in Neurons

    Article • Journal of Virology, July 2006, ASM Journals

    Professor Bryan R. G. Williams

  87. The lack of RNA-dependent protein kinase enhances susceptibility of mice to genital herpes simplex virus type 2 infection

    Article • Immunology, June 2006, Wiley

    Professor Bryan R. G. Williams

  88. Dynamic Flexibility of Double-stranded RNA Activated PKR in Solution

    Article • Journal of Molecular Biology, June 2006, Elsevier

    Professor Bryan R. G. Williams

  89. A structural basis for discriminating between self and nonself double-stranded RNAs in mammalian cells

    Article • Nature Biotechnology, April 2006, Springer Science + Business Media

    Professor Bryan R. G. Williams

  90. OAS and PKR Are Not Required for the Antiviral Effect of Ad:IFN- γ Against Acute HSV-1 in Primary Trigeminal Ganglia Cultures

    Article • Journal of Interferon & Cytokine Research, April 2006, Mary Ann Liebert Inc

    Professor Bryan R. G. Williams

  91. Stability of CXCL‐8 and Related AU‐Rich mRNAs in the Context of Hepatitis C Virus Replication In Vitro

    Article • The Journal of Infectious Diseases, March 2006, Oxford University Press (OUP)

    Professor Bryan R. G. Williams

  92. A systematic search for downstream mediators of tumor suppressor function of p53 reveals a major role of BTG2 in suppression of Ras-induced transformation

    Article • Genes & Development, January 2006, Cold Spring Harbor Laboratory Press

    Professor Bryan R. G. Williams

  93. Distinct roles of protein kinase R and toll-like receptor 3 in the activation of astrocytes by viral stimuli

    Article • Glia, January 2006, Wiley

    Professor Bryan R. G. Williams

  94. Vascular Endothelial Growth Factor (VEGF) Is Suppressed in WT1-Transfected LNCaP Cells

    Article • Gene Expression, January 2006, Cognizant Communication Corporation

    Professor Bryan R. G. Williams

  95. Efficient suppression of secretory clusterin levels by polymer-siRNA nanocomplexes enhances ionizing radiation lethality in human MCF-7 breast cancer cells in vitro

    Article • International Journal of Nanomedicine, January 2006, Taylor & Francis

    Professor Bryan R. G. Williams

  96. ARED 3.0: the large and diverse AU-rich transcriptome

    Article • Nucleic Acids Research, January 2006, Oxford University Press (OUP)

    Professor Bryan R. G. Williams

  97. “Endogenous adjuvant” activity of the RNA components of lupus autoantigens Sm/RNP and Ro 60

    Article • Arthritis & Rheumatism, January 2006, Wiley

    Professor Bryan R. G. Williams

  98. Activation of the mammalian immune system by siRNAs

    Article • Nature Biotechnology, November 2005, Springer Science + Business Media

    Professor Bryan R. G. Williams

  99. A transcriptional signaling pathway in the IFN system mediated by 2′-5′-oligoadenylate activation of RNase L

    Article • Proceedings of the National Academy of Sciences, October 2005, Proceedings of the National Academy of Sciences

    Professor Bryan R. G. Williams

  100. Targeting Specific Cell Types with Silencing RNA

    Article • New England Journal of Medicine, September 2005, New England Journal of Medicine (NEJM/MMS)

    Professor Bryan R. G. Williams

  101. Down-Regulation of p53 by Double-Stranded RNA Modulates the Antiviral Response

    Article • Journal of Virology, September 2005, ASM Journals

    Professor Bryan R. G. Williams

  102. RNA-Dependent Protein Kinase Is Required for Alpha-1 Interferon Transgene-Induced Resistance to Genital Herpes Simplex Virus Type 2

    Article • Journal of Virology, July 2005, ASM Journals

    Professor Bryan R. G. Williams

  103. Detection of foreign RNA: Implications for RNAi

    Article • Immunology and Cell Biology, June 2005, Wiley

    Professor Bryan R. G. Williams

  104. RNA interference in biology and disease

    Article • Blood, April 2005, American Society of Hematology

    Professor Bryan R. G. Williams

  105. Analysis of Genes Induced by Sendai Virus Infection of Mutant Cell Lines Reveals Essential Roles of Interferon Regulatory Factor 3, NF-κB, and Interferon but Not Toll-Like Receptor 3

    Article • Journal of Virology, April 2005, ASM Journals

    Professor Bryan R. G. Williams

  106. A Gene Expression Signature for Relapse of Primary Wilms Tumors

    Article • Cancer Research, April 2005, American Association for Cancer Research (AACR)

    Professor Bryan R. G. Williams

  107. Double-stranded RNA-dependent protein kinase (PKR) is downregulated by phorbol ester

    Article • FEBS Journal, March 2005, Wiley

    Professor Bryan R. G. Williams

  108. Expression of IFITM1 in chronic myeloid leukemia patients

    Article • Leukemia Research, March 2005, Elsevier

    Professor Bryan R. G. Williams

  109. Involvement of the Interferon-Regulated Antiviral Proteins PKR and RNase L in Reovirus-Induced Shutoff of Cellular Translation

    Article • Journal of Virology, February 2005, ASM Journals

    Professor Bryan R. G. Williams

  110. Dicing with siRNA

    Article • Nature Biotechnology, February 2005, Springer Science + Business Media

    Professor Bryan R. G. Williams

  111. Dichotomy between survival and lytic gene expression in RNase L- and PKR-deficient mice transduced with an adenoviral vector expressing murine IFN-β following ocular HSV-1 infection

    Article • Experimental Eye Research, February 2005, Elsevier

    Professor Bryan R. G. Williams

  112. AU-rich transient response transcripts in the human genome: expressed sequence tag clustering and gene discovery approach

    Article • Genomics, February 2005, Elsevier

    Professor Bryan R. G. Williams

  113. RNase L and Double-Stranded RNA-Dependent Protein Kinase Exert Complementary Roles in Islet Cell Defense during Coxsackievirus Infection

    Article • The Journal of Immunology, January 2005, The American Association of Immunologists

    Professor Bryan R. G. Williams

  114. Patterns of coordinate down-regulation of ARE-containing transcripts following immune cell activation

    Article • Genomics, December 2004, Elsevier

    Professor Bryan R. G. Williams

  115. Transcript profiling of Wilms tumors reveals connections to kidney morphogenesis and expression patterns associated with anaplasia

    Article • Oncogene, November 2004, Springer Science + Business Media

    Professor Bryan R. G. Williams

  116. RNA interference and double-stranded-RNA-activated pathways

    Article • Biochemical Society Transactions, November 2004, Portland Press Ltd.

    Professor Bryan R. G. Williams

  117. Expressed Gene Clusters Associated with Cellular Sensitivity and Resistance Towards Anti-viral and Anti-proliferative Actions of Interferon

    Article • Journal of Molecular Biology, September 2004, Elsevier

    Professor Bryan R. G. Williams

  118. Phospholipid Scramblase 1 Potentiates the Antiviral Activity of Interferon

    Article • Journal of Virology, September 2004, ASM Journals

    Professor Bryan R. G. Williams

  119. Biochemical Analyses of Multiple Fractions of PKR Purified from Escherichia coli

    Article • Journal of Interferon & Cytokine Research, September 2004, Mary Ann Liebert Inc

    Professor Bryan R. G. Williams

  120. PKR-Dependent and -Independent Mechanisms Are Involved in Translational Shutoff during Sindbis Virus Infection

    Article • Journal of Virology, August 2004, ASM Journals

    Professor Bryan R. G. Williams

  121. Synergistic Activation of Innate Immunity by Double-Stranded RNA and CpG DNA Promotes Enhanced Antitumor Activity

    Article • Cancer Research, August 2004, American Association for Cancer Research (AACR)

    Professor Bryan R. G. Williams

  122. Protein Kinase R (PKR) Interacts with and Activates Mitogen-activated Protein Kinase Kinase 6 (MKK6) in Response to Double-stranded RNA Stimulation

    Article • Journal of Biological Chemistry, June 2004, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Bryan R. G. Williams

  123. Induction of interferon-stimulated gene expression and antiviral responses require protein deacetylase activity

    Article • Proceedings of the National Academy of Sciences, June 2004, Proceedings of the National Academy of Sciences

    Professor Bryan R. G. Williams

  124. The Wilms Tumor Suppressor-1 Target Gene Podocalyxin Is Transcriptionally Repressed by p53

    Article • Journal of Biological Chemistry, May 2004, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Bryan R. G. Williams

  125. Distinctive Roles for 2',5'-Oligoadenylate Synthetases and Double-Stranded RNA-Dependent Protein Kinase R in the In Vivo Antiviral Effect of an Adenoviral Vector Expressing Murine IFN- 

    Article • The Journal of Immunology, April 2004, The American Association of Immunologists

    Professor Bryan R. G. Williams

  126. Limited role of N-terminal phosphoserine residues in the activation of transcription by p53

    Article • Oncogene, April 2004, Springer Science + Business Media

    Professor Bryan R. G. Williams

  127. Thrombomodulin RNA Is Destabilized Through Its 3′-Untranslated Element in Cells Exposed to IFN-γ

    Article • Journal of Interferon & Cytokine Research, December 2003, Mary Ann Liebert Inc

    Professor Bryan R. G. Williams

  128. Novel Growth and Death Related Interferon-Stimulated Genes (ISGs) in Melanoma: Greater Potency of IFN- β Compared with IFN- α 2

    Article • Journal of Interferon & Cytokine Research, December 2003, Mary Ann Liebert Inc

    Professor Bryan R. G. Williams

  129. Derivation and characterization of a Wilms' tumour cell line, WiT 49

    Article • International Journal of Cancer, September 2003, Wiley

    Professor Bryan R. G. Williams

  130. Activation of the interferon system by short-interfering RNAs

    Article • Nature Cell Biology, August 2003, Springer Science + Business Media

    Professor Bryan R. G. Williams

  131. The murine double-stranded RNA-dependent protein kinase PKR and the murine 2′,5′-oligoadenylate synthetase-dependent RNase L are required for IFN-β-mediated resistance against herpes simplex virus type 1 in primary trigeminal ganglion culture

    Article • Virology, August 2003, Elsevier

    Professor Bryan R. G. Williams

  132. Differential expression of E-cadherin and   catenin in primary and metastatic Wilms's tumours

    Article • Molecular Pathology, August 2003, BMJ

    Professor Bryan R. G. Williams

  133. TLR2 and TLR4 agonists stimulate unique repertoires of host resistance genes in murine macrophages: interferon-β-dependent signaling in TLR4-mediated responses

    Article • Journal of Endotoxin Research, June 2003, SAGE Publications

    Professor Bryan R. G. Williams

  134. IMMUNOLOGY: A Viral On/Off Switch for Interferon

    Article • Science, May 2003, American Association for the Advancement of Science

    Professor Bryan R. G. Williams

  135. Impaired Innate Host Defense Causes Susceptibility to Respiratory Virus Infections in Cystic Fibrosis

    Article • Immunity, May 2003, Elsevier

    Professor Bryan R. G. Williams

  136. C114 Is a Novel IL-11-inducible Nuclear Double-stranded RNA-binding Protein That Inhibits Protein Kinase R

    Article • Journal of Biological Chemistry, April 2003, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Bryan R. G. Williams

  137. Type I Interferon Induction Pathway, but Not Released Interferon, Participates in the Maturation of Dendritic Cells Induced by Negative‐Strand RNA Viruses

    Article • The Journal of Infectious Diseases, April 2003, Oxford University Press (OUP)

    Professor Bryan R. G. Williams, Dr Carolina B Lopez

  138. Poly(dI{middle dot}dC)-induced Toll-like Receptor 3 (TLR3)-mediated Activation of NFkappa B and MAP Kinase Is through an Interleukin-1 Receptor-associated Kinase (IRAK)-independent Pathway Employing the Signaling Components TLR3-TRAF6-TAK1-TAB2-PKR

    Article • Journal of Biological Chemistry, February 2003, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Bryan R. G. Williams

  139. ISG20, a New Interferon-induced RNase Specific for Single-stranded RNA, Defines an Alternative Antiviral Pathway against RNA Genomic Viruses

    Article • Journal of Biological Chemistry, February 2003, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Bryan R. G. Williams

  140. RNase L Mediates Transient Control of the Interferon Response through Modulation of the Double-stranded RNA-dependent Protein Kinase PKR

    Article • Journal of Biological Chemistry, February 2003, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Bryan R. G. Williams

  141. Alphavirus Minus-Strand Synthesis and Persistence in Mouse Embryo Fibroblasts Derived from Mice Lacking RNase L and Protein Kinase R

    Article • Journal of Virology, February 2003, ASM Journals

    Professor Bryan R. G. Williams

  142. Heterogeneity in Control of mRNA Stability by AU-rich Elements

    Article • Journal of Biological Chemistry, January 2003, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Bryan R. G. Williams

  143. p38 Mitogen-Activated Protein Kinase-Dependent and -Independent Signaling of mRNA Stability of AU-Rich Element-Containing Transcripts

    Article • Molecular and Cellular Biology, January 2003, ASM Journals

    Professor Bryan R. G. Williams

  144. ARED 2.0: an update of AU-rich element mRNA database

    Article • Nucleic Acids Research, January 2003, Oxford University Press (OUP)

    Professor Bryan R. G. Williams

  145. Article • APOPTOSIS, January 2003, Springer Science + Business Media

    Professor Bryan R. G. Williams

  146. Alphavirus-based DNA vaccine breaks immunological tolerance by activating innate antiviral pathways

    Article • Nature Reports Stem Cells, December 2002, Springer Science + Business Media

    Professor Bryan R. G. Williams

  147. Functional Replacement of the Carboxy-Terminal Two-Thirds of the Influenza A Virus NS1 Protein with Short Heterologous Dimerization Domains

    Article • Journal of Virology, December 2002, ASM Journals

    Professor Bryan R. G. Williams

  148. Absence of PKR Attenuates the Anti-HSV-1 Activity of an Adenoviral Vector Expressing Murine IFN- β

    Article • Journal of Interferon & Cytokine Research, August 2002, Mary Ann Liebert Inc

    Professor Bryan R. G. Williams

  149. Differential Effect of Murine Alpha/Beta Interferon Transgenes on Antagonization of Herpes Simplex Virus Type 1 Replication

    Article • Journal of Virology, July 2002, ASM Journals

    Professor Bryan R. G. Williams

  150. Blockade of Interferon Induction and Action by the E3L Double-Stranded RNA Binding Proteins of Vaccinia Virus

    Article • Journal of Virology, May 2002, ASM Journals

    Professor Bryan R. G. Williams

  151. TLR4, but not TLR2, mediates IFN-β–induced STAT1α/β-dependent gene expression in macrophages

    Article • Nature Immunology, March 2002, Springer Science + Business Media

    Professor Bryan R. G. Williams

  152. Interferon-Regulated Pathways That Control Hepatitis B Virus Replication in Transgenic Mice

    Article • Journal of Virology, March 2002, ASM Journals

    Professor Bryan R. G. Williams

  153. Editorial

    Article • Viral Immunology, March 2002, Mary Ann Liebert Inc

    Professor Bryan R. G. Williams

  154. Signal Integration via PKR

    Article • Science Signaling, July 2001, American Association for the Advancement of Science

    Professor Bryan R. G. Williams

  155. RNA-Dependent Protein Kinase PKR Is Required for Activation of NF- B by IFN-  in a STAT1-Independent Pathway

    Article • The Journal of Immunology, May 2001, The American Association of Immunologists

    Professor Bryan R. G. Williams

  156. Protein kinase PKR is required for platelet-derived growth factor signaling of c-fos gene expression via Erks and Stat3

    Article • The EMBO Journal, May 2001, Wiley

    Professor Bryan R. G. Williams

  157. The Role of NF-κB in the Regulation of the Expression of Wilms Tumor Suppressor Gene WT1

    Article • Gene Expression, March 2001, Cognizant Communication Corporation

    Professor Bryan R. G. Williams

  158. Expression and localization of HGF and met in Wilms' tumours

    Article • The Journal of Pathology, January 2001, Wiley

    Professor Bryan R. G. Williams

  159. ARED: human AU-rich element-containing mRNA database reveals an unexpectedly diverse functional repertoire of encoded proteins

    Article • Nucleic Acids Research, January 2001, Oxford University Press (OUP)

    Professor Bryan R. G. Williams

  160. Negative Regulation of CD8+ T Cell Function by the IFN-Induced and Double-Stranded RNA-Activated Kinase PKR

    Article • The Journal of Immunology, December 2000, The American Association of Immunologists

    Professor Bryan R. G. Williams

  161. Characterization of the Gene Encoding the 100-kDa Form of Human 2′,5′Oligoadenylate Synthetase

    Article • Genomics, December 2000, Elsevier

    Professor Bryan R. G. Williams

  162. A dynamically tuned double-stranded RNA binding mechanism for the activation of antiviral kinase PKR

    Article • The EMBO Journal, October 2000, Wiley

    Professor Bryan R. G. Williams

  163. Characterization of a 500-kb Contig Spanning the Region between c-Ha-Ras and MUC2 on Chromosome 11p15.5

    Article • Genomics, October 2000, Elsevier

    Professor Bryan R. G. Williams

  164. Identification of Connective Tissue Growth Factor as a Target of WT1 Transcriptional Regulation

    Article • September 2000, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Bryan R. G. Williams

  165. Identification of Critical Residues Required for Suppressor of Cytokine Signaling-specific Regulation of Interleukin-4 Signaling

    Article • Journal of Biological Chemistry, August 2000, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Bryan R. G. Williams

  166. The protein kinase PKR is required for p38 MAPK activation and the innate immune response to bacterial endotoxin

    Article • The EMBO Journal, August 2000, Wiley

    Professor Bryan R. G. Williams

  167. The B56α Regulatory Subunit of Protein Phosphatase 2A Is a Target for Regulation by Double-Stranded RNA-Dependent Protein Kinase PKR

    Article • Molecular and Cellular Biology, July 2000, ASM Journals

    Professor Bryan R. G. Williams

  168. Central Role of Double-Stranded RNA-Activated Protein Kinase in Microbial Induction of Nitric Oxide Synthase

    Article • The Journal of Immunology, July 2000, The American Association of Immunologists

    Professor Bryan R. G. Williams

  169. Effect of Deficiency of the Double-Stranded RNA-Dependent Protein Kinase, PKR, on Antiviral Resistance in the Presence or Absence of Ribonuclease L: HSV-1 Replication Is Particularly Sensitive to Deficiency of the Major IFN-Mediated Enzymes

    Article • Journal of Interferon & Cytokine Research, July 2000, Mary Ann Liebert Inc

    Professor Bryan R. G. Williams

  170. Specific phenotypic restoration of an attenuated virus by knockout of a host resistance gene

    Article • Proceedings of the National Academy of Sciences, May 2000, Proceedings of the National Academy of Sciences

    Professor Bryan R. G. Williams

  171. NF-κB Activation by Double-Stranded-RNA-Activated Protein Kinase (PKR) Is Mediated through NF-κB-Inducing Kinase and IκB Kinase

    Article • Molecular and Cellular Biology, February 2000, ASM Journals

    Professor Bryan R. G. Williams

  172. Induction of E-Selectin Expression by Double-Stranded RNA and TNF-  Is Attenuated in Murine Aortic Endothelial Cells Derived from Double-Stranded RNA-Activated Kinase (PKR)-Null Mice

    Article • The Journal of Immunology, February 2000, The American Association of Immunologists

    Professor Bryan R. G. Williams

  173. Regulation of c-myc expression by IFN-γ through Stat1-dependent and -independent pathways

    Article • The EMBO Journal, January 2000, Wiley

    Professor Bryan R. G. Williams

  174. Activation of p38 Mitogen-Activated Protein Kinase and c-Jun NH2-Terminal Kinase by Double-Stranded RNA and Encephalomyocarditis Virus: Involvement of RNase L, Protein Kinase R, and Alternative Pathways

    Article • Molecular and Cellular Biology, January 2000, ASM Journals

    Professor Bryan R. G. Williams

  175. HIV-I TAT Inhibits PKR Activity by Both RNA-Dependent and RNA-Independent Mechanisms

    Article • Archives of Biochemistry and Biophysics, January 2000, Elsevier

    Professor Bryan R. G. Williams

  176. JNK2 and IKKβ Are Required for Activating the Innate Response to Viral Infection

    Article • Immunity, December 1999, Elsevier

    Professor Bryan R. G. Williams

  177. The antiviral enzymes PKR and RNase L suppress gene expression from viral and non-viral based vectors

    Article • Nucleic Acids Research, November 1999, Oxford University Press (OUP)

    Professor Bryan R. G. Williams

  178. PKR; a sentinel kinase for cellular stress

    Article • Oncogene, November 1999, Springer Science + Business Media

    Professor Bryan R. G. Williams

  179. p38 MAP kinase is required for STAT1 serine phosphorylation and transcriptional activation induced by interferons

    Article • The EMBO Journal, October 1999, Wiley

    Professor Bryan R. G. Williams

  180. DRBP76, a Double-stranded RNA-binding Nuclear Protein, Is Phosphorylated by the Interferon-induced Protein Kinase, PKR

    Article • Journal of Biological Chemistry, July 1999, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Bryan R. G. Williams

  181. Interferon Action in Triply Deficient Mice Reveals the Existence of Alternative Antiviral Pathways

    Article • Virology, June 1999, Elsevier

    Professor Bryan R. G. Williams

  182. The DNA-binding subunit p140 of replication factor C is upregulated in cycling cells and associates with G 1 phase cell cycle regulatory proteins

    Article • Journal of Molecular Medicine, April 1999, Springer Science + Business Media

    Professor Bryan R. G. Williams

  183. Involvement of Double-stranded RNA-activated Protein Kinase in the Synergistic Activation of Nuclear Factor- B by Tumor Necrosis Factor-  and  -Interferon in Preneuronal Cells

    Article • Journal of Biological Chemistry, February 1999, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Bryan R. G. Williams

  184. Translational control perks up

    Article • Nature, January 1999, Springer Science + Business Media

    Professor Bryan R. G. Williams

  185. Cell cycle regulation of the double stranded RNA activated protein kinase, PKR

    Article • Oncogene, January 1999, Springer Science + Business Media

    Professor Bryan R. G. Williams

  186. Identification of genes differentially regulated by interferon α, β, or γ using oligonucleotide arrays

    Article • Proceedings of the National Academy of Sciences, December 1998, Proceedings of the National Academy of Sciences

    Professor Bryan R. G. Williams

  187. Protein-tyrosine Phosphatase Shp-1 Is a Negative Regulator of IL-4- and IL-13-dependent Signal Transduction

    Article • Journal of Biological Chemistry, December 1998, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Bryan R. G. Williams

  188. Constitutive expression of the Wilms tumor suppressor gene (WT1) in renal cell carcinoma

    Article • International Journal of Cancer, October 1998, Wiley

    Professor Bryan R. G. Williams

  189. Subcellular localization of the von Hippel-Lindau disease gene product is cell cycle-dependent

    Article • International Journal of Cancer, September 1998, Wiley

    Professor Bryan R. G. Williams

  190. Structure of the double-stranded RNA-binding domain of the protein kinase PKR reveals the molecular basis of its dsRNA-mediated activation

    Article • The EMBO Journal, September 1998, Wiley

    Professor Bryan R. G. Williams

  191. Genomic Features of Human PKR: Alternative Splicing and a Polymorphic CGG Repeat in the 5′-Untranslated Region

    Article • Journal of Interferon & Cytokine Research, August 1998, Mary Ann Liebert Inc

    Professor Bryan R. G. Williams

  192. Loss of heterozygosity at chromosome 11p15 in Wilms tumors: identification of two independent regions

    Article • Oncogene, July 1998, Springer Science + Business Media

    Professor Bryan R. G. Williams

  193. Review of Recent Developments in the Molecular Characterization of Recombinant Alfa Interferons on the 40th Anniversary of the Discovery of Interferon

    Article • Cancer Biotherapy & Radiopharmaceuticals, June 1998, Mary Ann Liebert Inc

    Professor Bryan R. G. Williams

  194. p53, bcl-2, and Bax Expression in Renal Cell Carcinoma

    Article • Urology, June 1998, Elsevier

    Professor Bryan R. G. Williams

  195. HOW CELLS RESPOND TO INTERFERONS

    Article • Annual Review of Biochemistry, June 1998, Annual Reviews

    Professor Bryan R. G. Williams

  196. Two distinct tumor suppressor loci within chromosome 11p15 implicated in breast cancer progression and metastasis

    Article • Human Molecular Genetics, May 1998, Oxford University Press (OUP)

    Professor Bryan R. G. Williams

  197. Mutations in the Double-stranded RNA-activated Protein Kinase Insert Region That Uncouple Catalysis from eIF2  Binding

    Article • Journal of Biological Chemistry, May 1998, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Bryan R. G. Williams

  198. Discussion

    Article • Cytokine & Growth Factor Reviews, March 1998, Elsevier

    Professor Bryan R. G. Williams

  199. Article • Journal of Biomolecular NMR, January 1998, Springer Science + Business Media

    Professor Bryan R. G. Williams

  200. Interferon gamma and interleukin 4 stimulate prolonged expression of inducible nitric oxide synthase in human airway epithelium through synthesis of soluble mediators.

    Article • Journal of Clinical Investigation, August 1997, American Society for Clinical Investigation

    Professor Bryan R. G. Williams

  201. Receptor-associated constitutive protein tyrosine phosphatase activity controls the kinase function of JAK1

    Article • Proceedings of the National Academy of Sciences, August 1997, Proceedings of the National Academy of Sciences

    Professor Bryan R. G. Williams

  202. Characterization of the Solution Complex between the Interferon-induced, Double-stranded RNA-activated Protein Kinase and HIV-I Trans-activating Region RNA

    Article • Journal of Biological Chemistry, April 1997, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Bryan R. G. Williams

  203. A double-stranded RNA-activated protein kinase-dependent pathway mediating stress-induced apoptosis

    Article • Proceedings of the National Academy of Sciences, April 1997, Proceedings of the National Academy of Sciences

    Professor Bryan R. G. Williams

  204. Deficient cytokine signaling in mouse embryo fibroblasts with a targeted deletion in the PKR gene: role of IRF-1 and NF-kappa B

    Article • The EMBO Journal, January 1997, Wiley

    Professor Bryan R. G. Williams, PhD Vincenzo Flati

  205. Specific Binding of the ETS-Domain Protein to the Interferon-Stimulated Response Element

    Article • Journal of Interferon & Cytokine Research, January 1997, Mary Ann Liebert Inc

    Professor Bryan R. G. Williams

  206. Tissue-specific regulation of theWT1 locus

    Article • Medical and Pediatric Oncology, November 1996, Wiley

    Professor Bryan R. G. Williams

  207. Expression of Intracellular Interferon Constitutively Activates ISGF3 and Confers Resistance to EMC Viral Infection

    Article • Journal of Interferon & Cytokine Research, July 1996, Mary Ann Liebert Inc

    Professor Bryan R. G. Williams

  208. Testicular cancer in association with developmental renal anomalies and hypospadias

    Article • Urology, January 1996, Elsevier

    Professor Bryan R. G. Williams

  209. Human PKR Transfected into Murine Cells Stimulates Expression of Genes under Control of the HIV1 or HTLV-I LTR

    Article • Virology, December 1995, Elsevier

    Professor Bryan R. G. Williams

  210. Analysis of the wilms tumor suppressor geneWT1 in endometrial carcinoma

    Article • Genes Chromosomes and Cancer, December 1995, Wiley

    Professor Bryan R. G. Williams

  211. HIV-1 Tat Directly Interacts with the Interferon-Induced, Double-Stranded RNA-Dependent Kinase, PKR

    Article • Virology, November 1995, Elsevier

    Professor Bryan R. G. Williams

  212. Roles of Protein-tyrosine Phosphatases in Stat1 -mediated Cell Signaling

    Article • Journal of Biological Chemistry, October 1995, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Bryan R. G. Williams, PhD Vincenzo Flati

  213. The interferon-inducible double-stranded RNA-activated protein kinase self-associates in vitro and in vivo.

    Article • Proceedings of the National Academy of Sciences, August 1995, Proceedings of the National Academy of Sciences

    Professor Bryan R. G. Williams

  214. In situ expression of the early growth response gene-1 during murine nephrogenesis

    Article • The Journal of Urology, August 1995, Elsevier

    Professor Bryan R. G. Williams

  215. The role of the dsRNA-activated kinase, PKR, in signal transduction

    Article • Seminars in Virology, June 1995, Elsevier

    Professor Bryan R. G. Williams

  216. Targeting RNA for Degradation with a (2', 5')-Oligoadenylate Antisense Chimera

    Article • Nucleosides Nucleotides & Nucleic Acids, May 1995, Taylor & Francis

    Professor Bryan R. G. Williams

  217. Response and Resistance to Interferons and Interacting Cytokines

    Article • JNCI Journal of the National Cancer Institute, February 1995, Oxford University Press (OUP)

    Professor Bryan R. G. Williams

  218. Mutational Analysis of the Double-stranded RNA (dsRNA) Binding Domain of the dsRNA-activated Protein Kinase, PKR

    Article • Journal of Biological Chemistry, February 1995, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Bryan R. G. Williams

  219. Microsatellite instability at a single locus (D11S988) on chromosome 11p15.5 as a late event in mammary tumorigenesis

    Article • Human Molecular Genetics, January 1995, Oxford University Press (OUP)

    Professor Bryan R. G. Williams

  220. HIV-1 TAR RNA Has an Intrinsic Ability to Activate Interferon-Inducible Enzymes

    Article • Virology, November 1994, Elsevier

    Professor Bryan R. G. Williams

  221. Blockage of NF-kappa B signaling by selective ablation of an mRNA target by 2-5A antisense chimeras

    Article • Science, August 1994, American Association for the Advancement of Science

    Professor Bryan R. G. Williams

  222. Double-stranded RNA-dependent protein kinase activates transcription factor NF-kappa B by phosphorylating I kappa B.

    Article • Proceedings of the National Academy of Sciences, July 1994, Proceedings of the National Academy of Sciences

    Professor Bryan R. G. Williams

  223. The Molecular Genetics of Wilms Tumor

    Article • Cancer Investigation, January 1994, Taylor & Francis

    Professor Bryan R. G. Williams

  224. Functional differences in the promoters of the interferon-inducible (2'-5')A oligoadenylate synthetase and 6-16 genes in interferon-resistant Daudi cells

    Article • European Journal of Biochemistry, January 1994, Wiley

    Professor Bryan R. G. Williams

  225. PKR: Proposed Nomenclature for the RNA-Dependent Protein Kinase Induced by Interferon

    Article • Journal of Interferon Research, June 1993, Mary Ann Liebert Inc

    Professor Bryan R. G. Williams

  226. Localization of the Human Interferon-Induced, ds-RNA Activated p68 Kinase Gene (PRKR) to Chromosome 2p21-p22

    Article • Genomics, June 1993, Elsevier

    Professor Bryan R. G. Williams

  227. Deletion ofWT1andWIT1Genes and Loss of Heterozygosity on Chromosome 11p in Wilms Tumors in Japan

    Article • Japanese Journal of Cancer Research, June 1993, Wiley

    Professor Bryan R. G. Williams

  228. Homozygous somatic Wt1 point mutations in sporadic unilateral Wilms tumor.

    Article • Proceedings of the National Academy of Sciences, February 1993, Proceedings of the National Academy of Sciences

    Professor Bryan R. G. Williams

  229. The Interferon-Induced Double-Stranded RNA-Activated Human p68 Protein Kinase Potently Inhibits Protein Synthesis in Cultured Cells

    Article • Virology, January 1993, Elsevier

    Professor Bryan R. G. Williams

  230. Molecular characterization of cytogenetic alterations associated with the Beckwith — Wiedemann syndrome (BWS) phenotype refines the localization and suggests the gene for BWS is imprinted

    Article • Human Molecular Genetics, January 1993, Oxford University Press (OUP)

    Professor Bryan R. G. Williams

  231. Loss of heterozygosity mapping in Wilms tumor indicates the involvement of three distinct regions and a limited role for nondisjunction or mitotic recombination

    Article • Genes Chromosomes and Cancer, November 1992, Wiley

    Professor Bryan R. G. Williams

  232. Interferon-α Activates Binding of Nuclear Factors to a Sequence Element in the c- fos Proto-Oncogene 5′-Flanking Region

    Article • Journal of Interferon Research, October 1992, Mary Ann Liebert Inc

    Professor Bryan R. G. Williams

  233. Transcriptional activation of human (2'-5')oligoadenylate synthetase gene expression by the phorbol ester 12-O-tetradecanoyl-phorbol 13-acetate in type-I-interferon-treated HL-60 and HeLa cells

    Article • European Journal of Biochemistry, July 1992, Wiley

    Professor Bryan R. G. Williams

  234. Basal expression of the gene (TIMP) encoding the murine tissue inhibitor of metalloproteinases is mediated through AP1- and CCAAT-binding factors

    Article • Gene, July 1992, Elsevier

    Professor Bryan R. G. Williams

  235. Identification of double-stranded RNA-binding domains in the interferon-induced double-stranded RNA-activated p68 kinase.

    Article • Proceedings of the National Academy of Sciences, June 1992, Proceedings of the National Academy of Sciences

    Professor Bryan R. G. Williams

  236. Multiple Tumor Suppressor Genes in Multistep Carcinogenesis.

    Article • The Tohoku Journal of Experimental Medicine, January 1992, Tohoku University Medical Press

    Professor Bryan R. G. Williams

  237. The distal region of 11p13 and associated genetic diseases

    Article • Genomics, October 1991, Elsevier

    Professor Bryan R. G. Williams

  238. Transcriptional regulation of interferon-stimulated genes

    Article • European Journal of Biochemistry, August 1991, Wiley

    Professor Bryan R. G. Williams

  239. Signal Transduction and Transcriptional Regulation of Interferon-α–Stimulated Genes

    Article • Journal of Interferon Research, August 1991, Mary Ann Liebert Inc

    Professor Bryan R. G. Williams

  240. Regulation of Tumor Necrosis Factor Receptor Expression by Acid-Labile Interferon-α from AIDS Sera

    Article • AIDS Research and Human Retroviruses, June 1991, Mary Ann Liebert Inc

    Professor Bryan R. G. Williams

  241. Direct pulsed field gel electrophoresis of Wilms' tumors shows that dna deletions in 11 p 13 are rare

    Article • Genes Chromosomes and Cancer, March 1991, Wiley

    Professor Bryan R. G. Williams

  242. Signal transduction by interferon-alpha through arachidonic acid metabolism

    Article • Science, January 1991, American Association for the Advancement of Science

    Professor Bryan R. G. Williams

  243. The murine 2-5A synthetase locus: three distinct transcripts from two linked genes

    Article • Nucleic Acids Research, January 1991, Oxford University Press (OUP)

    Professor Bryan R. G. Williams

  244. Molecular characterization of Beckwith-Wiedemann syndrome (BWS) patients with partial duplication of chromosome 11p excludes the gene MYOD1 from the BWS region

    Article • Genomics, December 1990, Elsevier

    Professor Bryan R. G. Williams

  245. Wilms tumor locus on 11p13 defined by multiple CpG island-associated transcripts

    Article • Science, November 1990, American Association for the Advancement of Science

    Professor Bryan R. G. Williams

  246. Tissue, developmental, and tumor-specific expression of divergent transcripts in Wilms tumor

    Article • Science, November 1990, American Association for the Advancement of Science

    Professor Bryan R. G. Williams

  247. Role for the Wilms tumor gene in genital development?

    Article • Proceedings of the National Academy of Sciences, July 1990, Proceedings of the National Academy of Sciences

    Professor Bryan R. G. Williams

  248. Molecular cloning and characterization of the human double-stranded RNA-activated protein kinase induced by interferon

    Article • Cell, July 1990, Elsevier

    Professor Bryan R. G. Williams

  249. Developmental expression of the endogenous TIMP gene and a TIMP-lacZ fusion gene in transgenic mice.

    Article • Genes & Development, July 1990, Cold Spring Harbor Laboratory Press

    Professor Bryan R. G. Williams

  250. Constitutional and somatic deletions of two different regions of maternal chromosome 11 in Wilms tumor

    Article • Genomics, July 1990, Elsevier

    Professor Bryan R. G. Williams

  251. Definition of the limits of the Wilms tumor locus on human chromosome 11p13

    Article • Genomics, February 1990, Elsevier

    Professor Bryan R. G. Williams

  252. X chromosome inactivation of the human TIMP gene

    Article • Nucleic Acids Research, January 1990, Oxford University Press (OUP)

    Professor Bryan R. G. Williams

  253. Constitutive Expression of a 2′,5′-Oligoadenylate Synthetase cDNA Results in Increased Antiviral Activity and Growth Suppression

    Article • Journal of Interferon Research, December 1989, Mary Ann Liebert Inc

    Professor Bryan R. G. Williams

  254. Interferon and growth factor modulation of nuclear factors binding to 5? upstream elements of the 2-5A synthetase gene

    Article • Journal of Cellular Biochemistry, December 1988, Wiley

    Professor Bryan R. G. Williams

  255. Downregulation of interferon alpha but not gamma receptor expression in vivo in the acquired immunodeficiency syndrome.

    Article • Journal of Clinical Investigation, October 1988, American Society for Clinical Investigation

    Professor Bryan R. G. Williams

  256. The interaction of interferon-α and -γ: Regulation of (2–5)A synthetase activity

    Article • Virology, July 1988, Elsevier

    Professor Bryan R. G. Williams

  257. Interferon and phorbol esters down-regulate slgM expression by independent pathways

    Article • Journal of Cellular Physiology, February 1988, Wiley

    Professor Bryan R. G. Williams

  258. Early Immune Response in Healthy and Immunocompromised Subjects with Primary Varicella-Zoster Virus Infection

    Article • The Journal of Infectious Diseases, September 1986, Oxford University Press (OUP)

    Professor Bryan R. G. Williams

  259. Interferon-regulated human 2–5A synthetase gene maps to chromosome 12

    Article • July 1986, Springer Science + Business Media

    Professor Bryan R. G. Williams

  260. Regulation of interferon receptor expression in human blood lymphocytes in vitro and during interferon therapy.

    Article • Journal of Clinical Investigation, May 1986, American Society for Clinical Investigation

    Professor Bryan R. G. Williams

  261. Differential human interferon alpha receptor expression on proliferating and non-proliferating cells

    Article • European Journal of Biochemistry, May 1986, Wiley

    Professor Bryan R. G. Williams

  262. RFLP detected by an X-Uinked cDNA encoding erythroid-potentiating activity/tissue inhibitor of metalloproteinase (EPA/TIMP)

    Article • Nucleic Acids Research, January 1986, Oxford University Press (OUP)

    Professor Bryan R. G. Williams

  263. Elevated Levels of Interferon-Induced 2'-5' Oligoadenylate Synthetase in Generalized Persistent Lymphadenopathy and the Acquired Immunodeficiency Syndrome

    Article • The Journal of Infectious Diseases, September 1985, Oxford University Press (OUP)

    Professor Bryan R. G. Williams

  264. Production and characterization of a monoclonal antibody to a human interferon-induced double-stranded RNA-binding Mr 68,000 protein kinase.

    Article • Proceedings of the National Academy of Sciences, August 1985, Proceedings of the National Academy of Sciences

    Professor Bryan R. G. Williams

  265. The effect of interferon on cells deficient in nucleoside transport or lacking thymidine kinase activity

    Article • Biochemical and Biophysical Research Communications, January 1984, Elsevier

    Professor Bryan R. G. Williams

  266. Molecular cloning of cDNAs from androgen-independent mRNA species of DBA/2 mouse sub-maxillary glands

    Article • Nucleic Acids Research, January 1984, Oxford University Press (OUP)

    Professor Bryan R. G. Williams

  267. Differential binding of human interferon-α subtypes to receptors on lymphoblastoid cells

    Article • Biochemical and Biophysical Research Communications, January 1983, Elsevier

    Professor Bryan R. G. Williams

  268. Molecular cloning of partial cDNA copies of two distinct mouse IFN-β mRNAs

    Article • Nucleic Acids Research, January 1982, Oxford University Press (OUP)

    Professor Bryan R. G. Williams

  269. The 2–5A (pppA2′ p5′ A2′ p5′ A) system in interferon-treated and control cells

    Article • Trends in Biochemical Sciences, May 1980, Elsevier

    Professor Bryan R. G. Williams

  270. Natural occurrence of 2-5A in interferon-treated EMC virus-infected L cells

    Article • Nature, December 1979, Springer Science + Business Media

    Professor Bryan R. G. Williams

  271. Activation of a nuclease by pppA2′p5′ A2′p5′ A in intact cells

    Article • FEBS Letters, September 1979, Wiley

    Professor Bryan R. G. Williams

  272. The respective roles of the protein kinase and pppA2′ p5′ A2′ p5′ A-activated endonuclease in the inhibition of protein synthesis by double stranded RNA in rabbit reticulocyte lysates

    Article • Nucleic Acids Research, January 1979, Oxford University Press (OUP)

    Professor Bryan R. G. Williams

  273. Synthesis and Breakdown of pppA2'p5'A2'p5'A and Transient Inhibition of Protein Synthesis in Extracts from Interferon-Treated and Control Cells

    Article • European Journal of Biochemistry, December 1978, Wiley

    Professor Bryan R. G. Williams

  274. Inhibition of protein synthesis by 2′–5′ linked adenine oligonucleotides in intact cells

    Article • Nature, November 1978, Springer Science + Business Media

    Professor Bryan R. G. Williams

  275. Inhibition of cell-free protein synthesis by pppA2′ p5′ A2′ p5′ A: a novel oligonucleotide synthesized by interferon-treated L cell extracts

    Article • Cell, March 1978, Elsevier

    Professor Bryan R. G. Williams

  276. Solid phase radioimmunoassays using labelled antibodies: A conceptual framework for designing assays

    Article • Journal of Immunological Methods, January 1977, Elsevier

    Professor Bryan R. G. Williams

  277. Detection of Double-Stranded RNA in Semliki Forest Virus-Infected Cells by an Indirect Solid Phase Radioimmunoassay: an Assay for Interferon

    Article • Intervirology, January 1977, Karger Publishers

    Professor Bryan R. G. Williams

  278. Antiviral response in insects?

    Article • Journal of Invertebrate Pathology, January 1977, Elsevier

    Professor Bryan R. G. Williams

  279. Wilms' Tumor as a Model for Cancer Biology

    Article • Springer Science + Business Media

    Professor Bryan R. G. Williams