All Stories

  1. Innate immune sensing of pathogens and its post-transcriptional regulations by RNA-binding proteins

    Article • Archives of Pharmacal Research, February 2023, Springer Science + Business Media

    Osamu Takeuchi

  2. The N6-methyladenosine methyltransferase METTL16 enables erythropoiesis through safeguarding genome integrity

    Article • Nature Communications, October 2022, Springer Science + Business Media

    Osamu Takeuchi

  3. Regnase-1 Prevents Pulmonary Arterial Hypertension Through mRNA Degradation of Interleukin-6 and Platelet-Derived Growth Factor in Alveolar Macrophages

    Article • Circulation, September 2022, Wolters Kluwer Health

    Osamu Takeuchi

  4. Androgens Alleviate Allergic Airway Inflammation by Suppressing Cytokine Production in Th2 Cells

    Article • The Journal of Immunology, September 2022, The American Association of Immunologists

    Osamu Takeuchi

  5. Enhancement of Regnase-1 expression with stem loop–targeting antisense oligonucleotides alleviates inflammatory diseases

    Article • Science Translational Medicine, May 2022, American Association for the Advancement of Science

    Osamu Takeuchi

  6. Cyclin J–CDK complexes limit innate immune responses by reducing proinflammatory changes in macrophage metabolism

    Article • Science Signaling, April 2022, American Association for the Advancement of Science

    Osamu Takeuchi

  7. DSP-crosslinking and Immunoprecipitation to Isolate Weak Protein Complex

    Article • BIO-PROTOCOL, January 2022, Bio-Protocol, LLC

    Osamu Takeuchi

  8. TANK prevents IFN-dependent fatal diffuse alveolar hemorrhage by suppressing DNA-cGAS aggregation

    Article • Life Science Alliance, November 2021, Life Science Alliance, LLC

    Osamu Takeuchi

  9. Posttranscriptional regulation of ILC2 homeostatic function via tristetraprolin

    Article • The Journal of Experimental Medicine, October 2021, Rockefeller University Press

    Osamu Takeuchi

  10. IRAK1-dependent Regnase-1-14-3-3 complex formation controls Regnase-1-mediated mRNA decay

    Article • eLife, October 2021, eLife

    Osamu Takeuchi

  11. Regnase‐1–related endoribonucleases in health and immunological diseases

    Article • Immunological Reviews, September 2021, Wiley

    Osamu Takeuchi

  12. Post-transcriptional regulation of immunological responses by Regnase-1-related RNases

    Article • International Immunology, July 2021, Oxford University Press (OUP)

    Osamu Takeuchi

  13. IRAK1-dependent Regnase-1-14-3-3 complex formation controls Regnase-1-mediated mRNA decay

    Article • July 2021, Cold Spring Harbor Laboratory Press

    Osamu Takeuchi

  14. Extracellular mRNA transported to the nucleus exerts translation-independent function

    Article • Nature Communications, June 2021, Springer Science + Business Media

    Osamu Takeuchi

  15. PIN and CCCH Zn-finger domains coordinate RNA targeting in ZC3H12 family endoribonucleases

    Article • Nucleic Acids Research, May 2021, Oxford University Press (OUP)

    Osamu Takeuchi

  16. The effects of codon bias and optimality on mRNA and protein regulation

    Article • Cellular and Molecular Life Sciences, October 2020, Springer Science + Business Media

    Osamu Takeuchi

  17. Profibrotic function of pulmonary group 2 innate lymphoid cells is controlled by regnase-1

    Article • European Respiratory Journal, September 2020, European Respiratory Society (ERS)

    Osamu Takeuchi

  18. The transcription factor E2A activates multiple enhancers that drive Rag expression in developing T and B cells

    Article • Science Immunology, September 2020, American Association for the Advancement of Science

    Osamu Takeuchi

  19. RNA Recognition and Immunity—Innate Immune Sensing and Its Posttranscriptional Regulation Mechanisms

    Article • Cells, July 2020, MDPI AG

    Osamu Takeuchi

  20. Zinc Finger Protein St18 Protects against Septic Death by Inhibiting VEGF-A from Macrophages

    Article • Cell Reports, July 2020, Elsevier

    Osamu Takeuchi

  21. Live-Cell Imaging of Protein Degradation Utilizing Designed Protein-Tag Mutant and Fluorescent Probe with Turn-Off Switch

    Article • Bioconjugate Chemistry, December 2019, American Chemical Society (ACS)

    Osamu Takeuchi

  22. Frequent mutations that converge on the NFKBIZ pathway in ulcerative colitis

    Article • Nature, December 2019, Springer Science + Business Media

    Osamu Takeuchi

  23. Codon bias confers stability to human mRNA s

    Article • EMBO Reports, September 2019, EMBO

    Osamu Takeuchi

  24. NET-CAGE characterizes the dynamics and topology of human transcribed cis-regulatory elements

    Article • Nature Genetics, September 2019, Springer Science + Business Media

    Piero Carninci, Osamu Takeuchi

  25. Translation-dependent unwinding of stem–loops by UPF1 licenses Regnase-1 to degrade inflammatory mRNAs

    Article • Nucleic Acids Research, July 2019, Oxford University Press (OUP)

    Osamu Takeuchi

  26. Dynamics and Topology of Human Transcribed Cis-regulatory Elements

    Article • July 2019, Cold Spring Harbor Laboratory Press

    Osamu Takeuchi

  27. N4BP1 restricts HIV-1 and its inactivation by MALT1 promotes viral reactivation

    Article • Nature Microbiology, May 2019, Springer Science + Business Media

    Osamu Takeuchi

  28. RNA binding proteins in the control of autoimmune diseases

    Article • Immunological Medicine, April 2019, Taylor & Francis

    Osamu Takeuchi

  29. Codon Bias Confers Stability to mRNAs via ILF2 in Humans

    Article • March 2019, Cold Spring Harbor Laboratory Press

    Osamu Takeuchi

  30. Post‐transcriptional control of immune responses and its potential application

    Article • Clinical & Translational Immunology, January 2019, Wiley

    Osamu Takeuchi

  31. Hassall’s corpuscles with cellular-senescence features maintain IFNα production through neutrophils and pDC activation in the thymus

    Article • International Immunology, December 2018, Oxford University Press (OUP)

    Osamu Takeuchi

  32. Translation of Hepatitis A Virus IRES Is Upregulated by a Hepatic Cell-Specific Factor

    Article • Frontiers in Genetics, August 2018, Frontiers

    Osamu Takeuchi

  33. Pulmonary Regnase-1 orchestrates the interplay of epithelium and adaptive immune systems to protect against pneumonia

    Article • Mucosal Immunology, July 2018, Elsevier

    ATSUYASU SATO, Osamu Takeuchi

  34. Post-transcriptional regulation of immune responses by RNA binding proteins

    Article • Proceedings of the Japan Academy Series B, June 2018, Japan Academy

    Osamu Takeuchi

  35. Regnase-1 and Roquin Nonredundantly Regulate Th1 Differentiation Causing Cardiac Inflammation and Fibrosis

    Article • The Journal of Immunology, December 2017, The American Association of Immunologists

    Osamu Takeuchi

  36. NSD3 keeps IRF3 active

    Article • The Journal of Experimental Medicine, November 2017, Rockefeller University Press

    Osamu Takeuchi

  37. Endonuclease Regnase-1/Monocyte chemotactic protein-1-induced protein-1 (MCPIP1) in controlling immune responses and beyond

    Article • Wiley Interdisciplinary Reviews - RNA, September 2017, Wiley

    Professor Osamu Takeuchi, Osamu Takeuchi

  38. Regnase-1 Maintains Iron Homeostasis via the Degradation of Transferrin Receptor 1 and Prolyl-Hydroxylase-Domain-Containing Protein 3 mRNAs

    Article • Cell Reports, May 2017, Elsevier

    Osamu Takeuchi

  39. Regnase-1 Is an Endoribonuclease Essential for the Maintenance of Immune Homeostasis

    Article • Journal of Interferon & Cytokine Research, May 2017, Mary Ann Liebert Inc

    Osamu Takeuchi

  40. Translational control of mRNAs by 3'-Untranslated region binding proteins

    Article • BMB Reports, April 2017, Korean Society for Biochemistry and Molecular Biology - BMB Reports

    Osamu Takeuchi

  41. Mitochondrial damage elicits a TCDD-inducible poly(ADP-ribose) polymerase-mediated antiviral response

    Article • Proceedings of the National Academy of Sciences, February 2017, Proceedings of the National Academy of Sciences

    Osamu Takeuchi

  42. Pathogen recognition and Toll-like receptor targeted therapeutics in innate immune cells

    Article • International Reviews of Immunology, January 2017, Taylor & Francis

    Osamu Takeuchi

  43. Nanoparticle‐Mediated Delivery of Mitochondrial Division Inhibitor 1 to the Myocardium Protects the Heart From Ischemia‐Reperfusion Injury Through Inhibition of Mitochondria Outer Membrane Permeabilization: A New Therapeutic Modality for Acute Myocardi...

    Article • Journal of the American Heart Association, July 2016, Wolters Kluwer Health

    Osamu Takeuchi

  44. Arid5a regulates naive CD4+ T cell fate through selective stabilization of Stat3 mRNA

    Article • The Journal of Experimental Medicine, March 2016, Rockefeller University Press

    Osamu Takeuchi

  45. Inhibition of IL-1R1/MyD88 signalling promotes mesenchymal stem cell-driven tissue regeneration

    Article • Nature Communications, March 2016, Springer Science + Business Media

    Osamu Takeuchi

  46. Structural basis for the regulation of enzymatic activity of Regnase-1 by domain-domain interactions

    Article • Scientific Reports, March 2016, Springer Science + Business Media

    Osamu Takeuchi

  47. Akirin2-Mediated Transcriptional Control by Recruiting SWI/SNF Complex in B Cells

    Article • Critical Reviews in Immunology, January 2016, Begell House

    Osamu Takeuchi

  48. Post-transcriptional regulation of inflammatory mRNA by Regnase-1 and Roquin

    Article • Folia Pharmacologica Japonica, January 2016, Japanese Pharmacological Society

    Osamu Takeuchi

  49. Chromatin Remodeling and Transcriptional Control in Innate Immunity: Emergence of Akirin2 as a Novel Player

    Article • Biomolecules, July 2015, MDPI AG

    Osamu Takeuchi

  50. Regnase-1 and Roquin regulate inflammatory mRNAs

    Article • Oncotarget, July 2015, Impact Journals, LLC

    Osamu Takeuchi

  51. Essential Function for the Nuclear Protein Akirin2 in B Cell Activation and Humoral Immune Responses

    Article • The Journal of Immunology, July 2015, The American Association of Immunologists

    Osamu Takeuchi

  52. A Lipopolysaccharide from Pantoea Agglomerans Is a Promising Adjuvant for Sublingual Vaccines to Induce Systemic and Mucosal Immune Responses in Mice via TLR4 Pathway

    Article • PLoS ONE, May 2015, PLOS

    Osamu Takeuchi

  53. HuR keeps interferon-β mRNA stable

    Article • European Journal of Immunology, May 2015, Wiley

    Professor Osamu Takeuchi, Osamu Takeuchi

  54. Regnase-1 and Roquin Regulate a Common Element in Inflammatory mRNAs by Spatiotemporally Distinct Mechanisms

    Article • Cell, May 2015, Elsevier

    Osamu Takeuchi

  55. 5-Azacytidine-induced Protein 2 (AZI2) Regulates Bone Mass by Fine-tuning Osteoclast Survival

    Article • Journal of Biological Chemistry, April 2015, Elsevier

    Osamu Takeuchi

  56. Nickel Ions Selectively Inhibit Lipopolysaccharide-Induced Interleukin-6 Production by Decreasing Its mRNA Stability

    Article • PLoS ONE, March 2015, PLOS

    Osamu Takeuchi

  57. Negative Regulation of Melanoma Differentiation-associated Gene 5 (MDA5)-dependent Antiviral Innate Immune Responses by Arf-like Protein 5B

    Article • Journal of Biological Chemistry, January 2015, Elsevier

    Osamu Takeuchi

  58. Posttranscriptional control of inflammation by an RNase Regnase-1

    Article • Folia Pharmacologica Japonica, January 2015, Japanese Pharmacological Society

    Osamu Takeuchi

  59. Hematopoietic IKBKE limits the chronicity of inflammasome priming and metaflammation

    Article • Proceedings of the National Academy of Sciences, December 2014, Proceedings of the National Academy of Sciences

    Osamu Takeuchi

  60. Dynamics of enhancers in myeloid antigen presenting cells upon LPS stimulation

    Article • BMC Genomics, December 2014, Springer Science + Business Media

    Osamu Takeuchi

  61. Akirin specifies NF ‐κB selectivity of Drosophila innate immune response via chromatin remodeling

    Article • The EMBO Journal, September 2014, EMBO

    Osamu Takeuchi

  62. Akirin2 is critical for inducing inflammatory genes by bridging I B-  and the SWI/SNF complex

    Article • The EMBO Journal, August 2014, EMBO

    Professor Osamu Takeuchi, Osamu Takeuchi

  63. Nucleic acid sensing by T cells initiates Th2 cell differentiation

    Article • Nature Communications, April 2014, Springer Science + Business Media

    Osamu Takeuchi

  64. Pivotal role of RNA-binding E3 ubiquitin ligase MEX3C in RIG-I–mediated antiviral innate immunity

    Article • Proceedings of the National Academy of Sciences, March 2014, Proceedings of the National Academy of Sciences

    Osamu Takeuchi

  65. The TNF Family Member 4-1BBL Sustains Inflammation by Interacting with TLR Signaling Components During Late-Phase Activation

    Article • Science Signaling, October 2013, American Association for the Advancement of Science

    Osamu Takeuchi

  66. Strawberry notch homologue 2 regulates osteoclast fusion by enhancing the expression of DC-STAMP

    Article • The Journal of Experimental Medicine, August 2013, Rockefeller University Press

    Osamu Takeuchi

  67. Zinc-finger antiviral protein mediates retinoic acid inducible gene I–like receptor-independent antiviral response to murine leukemia virus

    Article • Proceedings of the National Academy of Sciences, July 2013, Proceedings of the National Academy of Sciences

    Osamu Takeuchi

  68. Critical Role of AZI2 in GM-CSF–Induced Dendritic Cell Differentiation

    Article • The Journal of Immunology, June 2013, The American Association of Immunologists

    Osamu Takeuchi

  69. Double-Stranded RNA of Intestinal Commensal but Not Pathogenic Bacteria Triggers Production of Protective Interferon-β

    Article • Immunity, June 2013, Elsevier

    Osamu Takeuchi

  70. Arid5a controls IL-6 mRNA stability, which contributes to elevation of IL-6 level in vivo

    Article • Proceedings of the National Academy of Sciences, May 2013, Proceedings of the National Academy of Sciences

    Osamu Takeuchi

  71. Malt1-Induced Cleavage of Regnase-1 in CD4+ Helper T Cells Regulates Immune Activation

    Article • Cell, May 2013, Elsevier

    Osamu Takeuchi

  72. Essential Roles of K63-Linked Polyubiquitin-Binding Proteins TAB2 and TAB3 in B Cell Activation via MAPKs

    Article • The Journal of Immunology, April 2013, The American Association of Immunologists

    Osamu Takeuchi

  73. Post-transcriptional regulation of cytokine mRNA controls the initiation and resolution of inflammation

    Article • Biotechnology and Genetic Engineering Reviews, April 2013, Taylor & Francis

    Osamu Takeuchi

  74. IL-33 causes selective mast cell tolerance to bacterial cell wall products by inducing IRAK1 degradation

    Article • European Journal of Immunology, March 2013, Wiley

    Osamu Takeuchi

  75. Critical role of Trib1 in differentiation of tissue-resident M2-like macrophages

    Article • Nature, March 2013, Springer Science + Business Media

    Osamu Takeuchi

  76. The Transcription Factor Jdp2 Controls Bone Homeostasis and Antibacterial Immunity by Regulating Osteoclast and Neutrophil Differentiation

    Article • Immunity, December 2012, Elsevier

    Osamu Takeuchi

  77. TRAF Family Member-associated NF-κB Activator (TANK) Is a Negative Regulator of Osteoclastogenesis and Bone Formation

    Article • Journal of Biological Chemistry, August 2012, Elsevier

    Osamu Takeuchi

  78. IRF3: a molecular switch in pathogen responses

    Article • Nature Immunology, June 2012, Springer Science + Business Media

    Osamu Takeuchi

  79. CD44 Participates in IP-10 Induction in Cells in Which Hepatitis C Virus RNA Is Replicating, through an Interaction with Toll-Like Receptor 2 and Hyaluronan

    Article • Journal of Virology, April 2012, ASM Journals

    Osamu Takeuchi

  80. Bruton's tyrosine kinase phosphorylates Toll-like receptor 3 to initiate antiviral response

    Article • Proceedings of the National Academy of Sciences, March 2012, Proceedings of the National Academy of Sciences

    Osamu Takeuchi

  81. West Nile Virus Noncoding Subgenomic RNA Contributes to Viral Evasion of the Type I Interferon-Mediated Antiviral Response

    Article • Journal of Virology, February 2012, ASM Journals

    Osamu Takeuchi

  82. NO Is a Macrophage Autonomous Modifier of the Cytokine Response to Streptococcal Single-Stranded RNA

    Article • The Journal of Immunology, January 2012, The American Association of Immunologists

    Osamu Takeuchi

  83. The Toll-Like Receptor 3-Mediated Antiviral Response Is Important for Protection against Poliovirus Infection in Poliovirus Receptor Transgenic Mice

    Article • Journal of Virology, November 2011, ASM Journals

    Osamu Takeuchi

  84. The IκB kinase complex regulates the stability of cytokine-encoding mRNA induced by TLR–IL-1R by controlling degradation of regnase-1

    Article • Nature Immunology, October 2011, Springer Science + Business Media

    Osamu Takeuchi

  85. The TRAF-associated protein TANK facilitates cross-talk within the IκB kinase family during Toll-like receptor signaling

    Article • Proceedings of the National Academy of Sciences, September 2011, Proceedings of the National Academy of Sciences

    Osamu Takeuchi

  86. Essential Role of B7-H1 in Double-Stranded RNA–Induced Augmentation of an Asthma Phenotype in Mice

    Article • American Journal of Respiratory Cell and Molecular Biology, July 2011, American Thoracic Society

    Osamu Takeuchi

  87. Antiviral Protein Viperin Promotes Toll-like Receptor 7- and Toll-like Receptor 9-Mediated Type I Interferon Production in Plasmacytoid Dendritic Cells

    Article • Immunity, March 2011, Elsevier

    Osamu Takeuchi

  88. IL-1α Modulates Neutrophil Recruitment in Chronic Inflammation Induced by Hydrocarbon Oil

    Article • The Journal of Immunology, February 2011, The American Association of Immunologists

    Osamu Takeuchi

  89. Akt Contributes to Activation of the TRIF-Dependent Signaling Pathways of TLRs by Interacting with TANK-Binding Kinase 1

    Article • The Journal of Immunology, January 2011, The American Association of Immunologists

    Osamu Takeuchi

  90. Functional characterization of protein domains common to animal viruses and mouse

    Article • BMC Genomics, January 2011, Springer Science + Business Media

    Osamu Takeuchi

  91. Hepatitis C Virus Core Protein Abrogates the DDX3 Function That Enhances IPS-1-Mediated IFN–Beta Induction

    Article • PLoS ONE, December 2010, PLOS

    Osamu Takeuchi

  92. BID, BIM, and PUMA Are Essential for Activation of the BAX- and BAK-Dependent Cell Death Program

    Article • Science, December 2010, American Association for the Advancement of Science

    Osamu Takeuchi

  93. Immunological basis of M13 phage vaccine: Regulation under MyD88 and TLR9 signaling

    Article • Biochemical and Biophysical Research Communications, November 2010, Elsevier

    Osamu Takeuchi

  94. Negative Regulators in Toll-like Receptor Responses

    Article • Cornea, November 2010, Wolters Kluwer Health

    Osamu Takeuchi

  95. IκBζ is essential for natural killer cell activation in response to IL-12 and IL-18

    Article • Proceedings of the National Academy of Sciences, September 2010, Proceedings of the National Academy of Sciences

    Osamu Takeuchi

  96. The Jmjd3-Irf4 axis regulates M2 macrophage polarization and host responses against helminth infection

    Article • Nature Immunology, August 2010, Springer Science + Business Media

    Osamu Takeuchi

  97. Polyubiquitin conjugation to NEMO by triparite motif protein 23 (TRIM23) is critical in antiviral defense

    Article • Proceedings of the National Academy of Sciences, August 2010, Proceedings of the National Academy of Sciences

    Osamu Takeuchi

  98. Protein Kinase R Contributes to Immunity against Specific Viruses by Regulating Interferon mRNA Integrity

    Article • Cell Host & Microbe, May 2010, Elsevier

    Professor Jan Rehwinkel, Osamu Takeuchi

  99. Human lactoferrin activates NF-κB through the Toll-like receptor 4 pathway while it interferes with the lipopolysaccharide-stimulated TLR4 signaling

    Article • FEBS Journal, March 2010, Wiley

    Osamu Takeuchi

  100. Pattern Recognition Receptors and Inflammation

    Article • Cell, March 2010, Elsevier

    Osamu Takeuchi

  101. An Slfn2 mutation causes lymphoid and myeloid immunodeficiency due to loss of immune cell quiescence

    Article • Nature Immunology, February 2010, Springer Science + Business Media

    Osamu Takeuchi

  102. LGP2 is a positive regulator of RIG-I– and MDA5-mediated antiviral responses

    Article • Proceedings of the National Academy of Sciences, January 2010, Proceedings of the National Academy of Sciences

    Osamu Takeuchi

  103. p53 Controls Radiation-Induced Gastrointestinal Syndrome in Mice Independent of Apoptosis

    Article • Science, December 2009, American Association for the Advancement of Science

    Carla Kim, Osamu Takeuchi

  104. Direct recognition of the mycobacterial glycolipid, trehalose dimycolate, by C-type lectin Mincle

    Article • The Journal of Experimental Medicine, December 2009, Rockefeller University Press

    Dr Yasu S. Morita, Osamu Takeuchi

  105. Atg9a controls dsDNA-driven dynamic translocation of STING and the innate immune response

    Article • Proceedings of the National Academy of Sciences, December 2009, Proceedings of the National Academy of Sciences

    Dr Takeshi Noda, Osamu Takeuchi

  106. Stepwise Activation of BAX and BAK by tBID, BIM, and PUMA Initiates Mitochondrial Apoptosis

    Article • Molecular Cell, November 2009, Elsevier

    Osamu Takeuchi

  107. A selective contribution of the RIG-I-like receptor pathway to type I interferon responses activated by cytosolic DNA

    Article • Proceedings of the National Academy of Sciences, October 2009, Proceedings of the National Academy of Sciences

    Osamu Takeuchi

  108. Poly I:C-Induced Activation of NK Cells by CD8α+ Dendritic Cells via the IPS-1 and TRIF-Dependent Pathways

    Article • The Journal of Immunology, August 2009, The American Association of Immunologists

    Osamu Takeuchi

  109. TANK is a negative regulator of Toll-like receptor signaling and is critical for the prevention of autoimmune nephritis

    Article • Nature Immunology, August 2009, Springer Science + Business Media

    Osamu Takeuchi

  110. Activation of MDA5 Requires Higher-Order RNA Structures Generated during Virus Infection

    Article • Journal of Virology, August 2009, ASM Journals

    Osamu Takeuchi

  111. Recognition of 5′ Triphosphate by RIG-I Helicase Requires Short Blunt Double-Stranded RNA as Contained in Panhandle of Negative-Strand Virus

    Article • Immunity, July 2009, Elsevier

    Professor Eicke Latz, Osamu Takeuchi

  112. Baculovirus Induces Type I Interferon Production through Toll-Like Receptor-Dependent and -Independent Pathways in a Cell-Type-Specific Manner

    Article • Journal of Virology, May 2009, ASM Journals

    Osamu Takeuchi

  113. TRAF6 Establishes Innate Immune Responses by Activating NF-κB and IRF7 upon Sensing Cytosolic Viral RNA and DNA

    Article • PLoS ONE, May 2009, PLOS

    Osamu Takeuchi

  114. Cutting Edge: TLR-Dependent Viral Recognition Along with Type I IFN Positive Feedback Signaling Masks the Requirement of Viral Replication for IFN-α Production in Plasmacytoid Dendritic Cells

    Article • The Journal of Immunology, April 2009, The American Association of Immunologists

    Osamu Takeuchi

  115. Zc3h12a is an RNase essential for controlling immune responses by regulating mRNA decay

    Article • Nature, March 2009, Springer Science + Business Media

    Osamu Takeuchi

  116. Selective roles for antiapoptotic MCL-1 during granulocyte development and macrophage effector function

    Article • Blood, March 2009, American Society of Hematology

    Osamu Takeuchi

  117. The Triacylated ATP Binding Cluster Transporter Substrate-binding Lipoprotein of Staphylococcus aureus Functions as a Native Ligand for Toll-like Receptor 2

    Article • Journal of Biological Chemistry, March 2009, Elsevier

    Osamu Takeuchi

  118. C-type lectin Mincle is an activating receptor for pathogenic fungus,Malassezia

    Article • Proceedings of the National Academy of Sciences, February 2009, Proceedings of the National Academy of Sciences

    Osamu Takeuchi

  119. Innate immunity to virus infection

    Article • Immunological Reviews, January 2009, Wiley

    Osamu Takeuchi

  120. Regulation of lymphocyte progenitor survival by the proapoptotic activities of Bim and Bid

    Article • Proceedings of the National Academy of Sciences, December 2008, Proceedings of the National Academy of Sciences

    Osamu Takeuchi

  121. RIG-I-like antiviral protein in flies

    Article • Nature Immunology, December 2008, Springer Science + Business Media

    Osamu Takeuchi

  122. TLR7-dependent and FcγR-independent production of type I interferon in experimental mouse lupus

    Article • The Journal of Experimental Medicine, December 2008, Rockefeller University Press

    Osamu Takeuchi

  123. Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production

    Article • Nature, October 2008, Nature

    Dr Takeshi Noda, Osamu Takeuchi

  124. Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid–inducible gene-I and melanoma differentiation–associated gene 5

    Article • The Journal of Experimental Medicine, June 2008, Rockefeller University Press

    Osamu Takeuchi

  125. TLR9 as a key receptor for the recognition of DNA☆

    Article • Advanced Drug Delivery Reviews, April 2008, Elsevier

    Osamu Takeuchi

  126. Sequential control of Toll-like receptor–dependent responses by IRAK1 and IRAK2

    Article • Nature Immunology, April 2008, Springer Science + Business Media

    Osamu Takeuchi

  127. Erratum: Akirins are highly conserved nuclear proteins required for NF-κB-dependent gene expression in drosophila and mice

    Article • Nature Immunology, February 2008, Springer Science + Business Media

    Osamu Takeuchi

  128. MDA5/RIG-I and virus recognition

    Article • Current Opinion in Immunology, February 2008, Elsevier

    Osamu Takeuchi

  129. TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines

    Article • Nature, February 2008, Springer Science + Business Media

    Osamu Takeuchi

  130. Pathogen recognition by innate receptors

    Article • Journal of Infection and Chemotherapy, January 2008, Elsevier

    Osamu Takeuchi

  131. Akirins are highly conserved nuclear proteins required for NF-κB-dependent gene expression in drosophila and mice

    Article • Nature Immunology, December 2007, Springer Science + Business Media

    Osamu Takeuchi

  132. Recognition of viruses by innate immunity

    Article • Immunological Reviews, December 2007, Wiley

    Osamu Takeuchi

  133. Lymphocytoid Choriomeningitis Virus Activates Plasmacytoid Dendritic Cells and Induces a Cytotoxic T-Cell Response via MyD88

    Article • Journal of Virology, October 2007, ASM Journals

    Osamu Takeuchi

  134. Genetic analysis of resistance to viral infection

    Article • Nature Reviews Immunology, October 2007, Springer Science + Business Media

    Osamu Takeuchi

  135. Enhanced TLR-mediated NF-IL6–dependent gene expression by Trib1 deficiency

    Article • The Journal of Experimental Medicine, August 2007, Rockefeller University Press

    Osamu Takeuchi

  136. A spatially and temporally restricted mouse model of soft tissue sarcoma

    Article • Nature Medicine, August 2007, Springer Science + Business Media

    Osamu Takeuchi

  137. Alveolar Macrophages Are the Primary Interferon-α Producer in Pulmonary Infection with RNA Viruses

    Article • Immunity, August 2007, Elsevier

    Osamu Takeuchi

  138. TLR4 signaling: negative regulation by degradation

    Article • Blood, August 2007, American Society of Hematology

    Osamu Takeuchi

  139. Hepatitis C Virus Nonstructural Protein 5A Modulates the Toll-Like Receptor-MyD88-Dependent Signaling Pathway in Macrophage Cell Lines

    Article • Journal of Virology, June 2007, ASM Journals

    Osamu Takeuchi

  140. Essential role of IRAK-4 protein and its kinase activity in Toll-like receptor–mediated immune responses but not in TCR signaling

    Article • The Journal of Experimental Medicine, May 2007, Rockefeller University Press

    Osamu Takeuchi

  141. Signaling pathways activated by microorganisms

    Article • Current Opinion in Cell Biology, April 2007, Elsevier

    Osamu Takeuchi

  142. TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity

    Article • Nature, March 2007, Springer Science + Business Media

    Osamu Takeuchi

  143. Cutting Edge: Pivotal Function of Ubc13 in Thymocyte TCR Signaling

    Article • The Journal of Immunology, December 2006, The American Association of Immunologists

    Osamu Takeuchi

  144. VP1686, a Vibrio Type III Secretion Protein, Induces Toll-like Receptor-independent Apoptosis in Macrophage through NF-κB Inhibition

    Article • Journal of Biological Chemistry, December 2006, Elsevier

    Osamu Takeuchi

  145. Pathological role of Toll-like receptor signaling in cerebral malaria

    Article • International Immunology, November 2006, Oxford University Press (OUP)

    Osamu Takeuchi

  146. TAK1 is indispensable for development of T cells and prevention of colitis by the generation of regulatory T cells

    Article • International Immunology, August 2006, Oxford University Press (OUP)

    Osamu Takeuchi

  147. Key function for the Ubc13 E2 ubiquitin-conjugating enzyme in immune receptor signaling

    Article • Nature Immunology, July 2006, Springer Science + Business Media

    Osamu Takeuchi

  148. Detection of pathogenic intestinal bacteria by Toll-like receptor 5 on intestinal CD11c+ lamina propria cells

    Article • Nature Immunology, July 2006, Springer Science + Business Media

    Osamu Takeuchi

  149. Essential role of IPS-1 in innate immune responses against RNA viruses

    Article • The Journal of Experimental Medicine, June 2006, Rockefeller University Press

    Osamu Takeuchi

  150. Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses

    Article • Nature, April 2006, Springer Science + Business Media

    Osamu Takeuchi

  151. Erratum: A Toll-like receptor–independent antiviral response induced by double-stranded B-form DNA

    Article • Nature Immunology, April 2006, Springer Science + Business Media

    Osamu Takeuchi

  152. Differential inductions of TNF-alpha and IGTP, IIGP by structurally diverse classic and non-classic lipopolysaccharides

    Article • Cellular Microbiology, March 2006, Hindawi Publishing Corporation

    Professor Ignacio Moriyon, Osamu Takeuchi

  153. Pathogen Recognition and Innate Immunity

    Article • Cell, February 2006, Elsevier

    Osamu Takeuchi

  154. Suppressor of cytokine signaling-1 selectively inhibits LPS-induced IL-6 production by regulating JAK–STAT

    Article • Proceedings of the National Academy of Sciences, November 2005, Proceedings of the National Academy of Sciences

    Osamu Takeuchi

  155. A Toll-like receptor–independent antiviral response induced by double-stranded B-form DNA

    Article • Nature Immunology, November 2005, Springer Science + Business Media

    Osamu Takeuchi

  156. Escherichia coliverotoxin 1 mediates apoptosis in human HCT116 colon cancer cells by inducing overexpression of the GADD family of genes and S phase arrest

    Article • FEBS Letters, November 2005, Wiley

    Osamu Takeuchi

  157. Viral recognition and type I interferon production by Toll-like receptor and an RNA helicase, RIG-I

    Article • International Congress Series, November 2005, Elsevier

    Osamu Takeuchi

  158. Essential function for the kinase TAK1 in innate and adaptive immune responses

    Article • Nature Immunology, September 2005, Springer Science + Business Media

    Osamu Takeuchi

  159. Involvement of Toll-Like Receptor 2 in Experimental Invasive Pulmonary Aspergillosis

    Article • Infection and Immunity, September 2005, ASM Journals

    Osamu Takeuchi

  160. Microarray analysis identifies apoptosis regulatory gene expression in HCT116 cells infected with thermostable direct hemolysin-deletion mutant of Vibrio parahaemolyticus

    Article • Biochemical and Biophysical Research Communications, September 2005, Elsevier

    Osamu Takeuchi

  161. IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction

    Article • Nature Immunology, August 2005, Springer Science + Business Media

    Osamu Takeuchi

  162. Cyclophilin D is a component of mitochondrial permeability transition and mediates neuronal cell death after focal cerebral ischemia

    Article • Proceedings of the National Academy of Sciences, August 2005, Proceedings of the National Academy of Sciences

    Osamu Takeuchi

  163. Essential role of BAX,BAK in B cell homeostasis and prevention of autoimmune disease

    Article • Proceedings of the National Academy of Sciences, July 2005, Proceedings of the National Academy of Sciences

    Osamu Takeuchi

  164. Cell Type-Specific Involvement of RIG-I in Antiviral Response

    Article • Immunity, July 2005, Elsevier

    Osamu Takeuchi

  165. Role of Lipoteichoic Acid in the Phagocyte Response to Group B Streptococcus

    Article • The Journal of Immunology, May 2005, The American Association of Immunologists

    Osamu Takeuchi

  166. Interleukin-1 receptor-associated kinase-1 plays an essential role for Toll-like receptor (TLR)7- and TLR9-mediated interferon-α induction

    Article • The Journal of Experimental Medicine, March 2005, Rockefeller University Press

    Osamu Takeuchi

  167. Regulation of lipopolysaccharide-inducible genes by MyD88 and Toll/IL-1 domain containing adaptor inducing IFN-β

    Article • Biochemical and Biophysical Research Communications, March 2005, Elsevier

    Osamu Takeuchi

  168. Toll-like receptor 9 mediates innate immune activation by the malaria pigment hemozoin

    Article • The Journal of Experimental Medicine, January 2005, Rockefeller University Press

    Osamu Takeuchi

  169. Toll-Like Receptor 2 MediatesStaphylococcus aureus–Induced Myocardial Dysfunction and Cytokine Production in the Heart

    Article • Circulation, December 2004, Wolters Kluwer Health

    Osamu Takeuchi

  170. Interferon-α induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6

    Article • Nature Immunology, September 2004, Springer Science + Business Media

    Osamu Takeuchi

  171. Interferon response induced by Toll-like receptor signaling

    Article • Journal of Endotoxin Research, August 2004, SAGE Publications

    Osamu Takeuchi

  172. Regulation of Toll/IL-1-receptor-mediated gene expression by the inducible nuclear protein IκBζ

    Article • Nature, July 2004, Springer Science + Business Media

    Osamu Takeuchi

  173. The Roles of Two IκB Kinase-related Kinases in Lipopolysaccharide and Double Stranded RNA Signaling and Viral Infection

    Article • The Journal of Experimental Medicine, June 2004, Rockefeller University Press

    Osamu Takeuchi

  174. Toll-Like Receptor 4 Mediates the Antitumor Host Response Induced by a 55-Kilodalton Protein Isolated from Aeginetia indica L., a Parasitic Plant

    Article • Clinical and Diagnostic Laboratory Immunology, May 2004, ASM Journals

    Osamu Takeuchi

  175. Lipopolysaccharide from Coxiella burnetii Is Involved in Bacterial Phagocytosis, Filamentous Actin Reorganization, and Inflammatory Responses through Toll-Like Receptor 4

    Article • The Journal of Immunology, March 2004, The American Association of Immunologists

    Osamu Takeuchi

  176. Toll-Like Receptor 2 Plays a Role in the Early Inflammatory Response to Murine Pneumococcal Pneumonia but Does Not Contribute to Antibacterial Defense

    Article • The Journal of Immunology, March 2004, The American Association of Immunologists

    Osamu Takeuchi

  177. Inhibitory Effect of Toll-Like Receptor 4 on Fusion between Phagosomes and Endosomes/Lysosomes in Macrophages

    Article • The Journal of Immunology, February 2004, The American Association of Immunologists

    Osamu Takeuchi

  178. Limited role of the Toll-like receptor-2 in resistance to Mycobacterium avium

    Article • Immunology, February 2004, Wiley

    Osamu Takeuchi

  179. Article • Nippon Saikingaku Zasshi, January 2004, Japanese Society for Bacteriology

    Osamu Takeuchi

  180. Toll-Like Receptor-2 Modulates Ventricular Remodeling After Myocardial Infarction

    Article • Circulation, December 2003, Wolters Kluwer Health

    Osamu Takeuchi

  181. Normal Development of the Gut-Associated Lymphoid Tissue Except Peyer's Patch in MyD88-Deficient Mice

    Article • Scandinavian Journal of Immunology, December 2003, Wiley

    Osamu Takeuchi

  182. TRAM is specifically involved in the Toll-like receptor 4–mediated MyD88-independent signaling pathway

    Article • Nature Immunology, October 2003, Springer Science + Business Media

    Osamu Takeuchi

  183. TLR2 as an essential molecule for protective immunity against Toxoplasma gondii infection

    Article • International Immunology, September 2003, Oxford University Press (OUP)

    Osamu Takeuchi

  184. Simultaneous Blocking of Human Toll-Like Receptors 2 and 4 Suppresses Myeloid Dendritic Cell Activation Induced by Mycobacterium bovis Bacillus Calmette-Guérin Peptidoglycan

    Article • Infection and Immunity, August 2003, ASM Journals

    Osamu Takeuchi

  185. Role of Adaptor TRIF in the MyD88-Independent Toll-Like Receptor Signaling Pathway

    Article • Science, August 2003, American Association for the Advancement of Science

    Osamu Takeuchi

  186. Candida albicansPhospholipomannan Is Sensed through Toll‐Like Receptors

    Article • The Journal of Infectious Diseases, July 2003, Oxford University Press (OUP)

    Osamu Takeuchi

  187. Synergistic effects of lipopolysaccharide and interferon-γ in inducing interleukin-8 production in human monocytic THP-1 cells is accompanied by up-regulation of CD14, Toll-like receptor 4, MD-2 and MyD88 expression

    Article • Journal of Endotoxin Research, June 2003, SAGE Publications

    Osamu Takeuchi

  188. Mycobacterial Infection in TLR2 and TLR6 Knockout Mice

    Article • Microbiology and Immunology, May 2003, Wiley

    Osamu Takeuchi

  189. CD19 regulates innate immunity by the toll-like receptor RP105 signaling in B lymphocytes

    Article • Blood, April 2003, American Society of Hematology

    Osamu Takeuchi

  190. Involvement of Toll-Like Receptor 4 Signaling in Interferon-  Production and Antitumor Effect by Streptococcal Agent OK-432

    Article • JNCI Journal of the National Cancer Institute, February 2003, Oxford University Press (OUP)

    Osamu Takeuchi

  191. Differential recognition of structural details of bacterial lipopeptides by toll-like receptors

    Article • European Journal of Immunology, December 2002, Wiley

    Osamu Takeuchi

  192. Recognition of lipopeptides by Toll-like receptors

    Article • Journal of Endotoxin Research, December 2002, SAGE Publications

    Osamu Takeuchi

  193. Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4

    Article • Nature, November 2002, Springer Science + Business Media

    Osamu Takeuchi

  194. SOCS-1 Participates in Negative Regulation of LPS Responses

    Article • Immunity, November 2002, Elsevier

    Osamu Takeuchi

  195. Cellular Activation, Phagocytosis, and Bactericidal Activity Against Group B Streptococcus Involve Parallel Myeloid Differentiation Factor 88-Dependent and Independent Signaling Pathways

    Article • The Journal of Immunology, October 2002, The American Association of Immunologists

    Osamu Takeuchi

  196. Critical Roles of Myeloid Differentiation Factor 88-Dependent Proinflammatory Cytokine Release in Early Phase Clearance of Listeria monocytogenes in Mice

    Article • The Journal of Immunology, October 2002, The American Association of Immunologists

    Osamu Takeuchi

  197. Differential involvement of IFN-  in Toll-like receptor-stimulated dendritic cell activation

    Article • International Immunology, October 2002, Oxford University Press (OUP)

    Osamu Takeuchi

  198. Involvement of Toll-like Receptor (TLR) 2 and TLR4 in Cell Activation by Mannuronic Acid Polymers

    Article • Journal of Biological Chemistry, September 2002, Elsevier

    Osamu Takeuchi

  199. Roles of Toll-Like Receptors in C-C Chemokine Production by Renal Tubular Epithelial Cells

    Article • The Journal of Immunology, August 2002, The American Association of Immunologists

    Osamu Takeuchi

  200. Activation of Toll-Like Receptor 2 in Acne Triggers Inflammatory Cytokine Responses

    Article • The Journal of Immunology, August 2002, The American Association of Immunologists

    Osamu Takeuchi

  201. Cutting Edge: Role of Toll-Like Receptor 1 in Mediating Immune Response to Microbial Lipoproteins

    Article • The Journal of Immunology, July 2002, The American Association of Immunologists

    Osamu Takeuchi

  202. Genetic approaches to the study of Toll-like receptor function

    Article • Microbes and Infection, July 2002, Elsevier

    Osamu Takeuchi

  203. Human Gingival CD14+ Fibroblasts Primed with Gamma Interferon Increase Production of Interleukin-8 in Response to Lipopolysaccharide through Up-Regulation of Membrane CD14 and MyD88 mRNA Expression

    Article • Infection and Immunity, March 2002, ASM Journals

    Osamu Takeuchi

  204. Toxoplasma gondii–derived heat shock protein HSP70 functions as a B cell mitogen

    Article • Cell Stress and Chaperones, January 2002, Springer Science + Business Media

    Osamu Takeuchi