All Stories

  1. Roles of Mitochondrial Sirtuins in Mitochondrial Function, Redox Homeostasis, Insulin Resistance and Type 2 Diabetes

    Article • International Journal of Molecular Sciences, July 2020, MDPI AG

    Yau-Huei Wei

  2. Cbl Negatively Regulates NLRP3 Inflammasome Activation through GLUT1-Dependent Glycolysis Inhibition

    Article • International Journal of Molecular Sciences, July 2020, MDPI AG

    Yau-Huei Wei

  3. Hyaluronan Induces a Mitochondrial Functional Switch in Fast-Proliferating Human Mesenchymal Stem

    Article • International Journal of Stem Cells, March 2020, Korean Society for Stem Cell Research

    Yau-Huei Wei

  4. Targeting cancer stem cells from a metabolic perspective

    Article • Experimental Biology and Medicine, February 2020, SAGE Publications

    Yau-Huei Wei

  5. Involvement of increased p53 expression in the decrease of mitochondrial DNA copy number and increase of SUVmax of FDG-PET scan in esophageal squamous cell carcinoma

    Article • Mitochondrion, July 2019, Elsevier

    Professor and Director Yau-Huei Wei, Yau-Huei Wei

  6. Alterations of oxygen consumption and extracellular acidification rates by glutamine in PBMCs of SLE patients

    Article • Mitochondrion, January 2019, Elsevier

    Professor and Director Yau-Huei Wei, Yau-Huei Wei

  7. Low mitochondrial DNA copy number of resected cecum appendix correlates with high severity of acute appendicitis

    Article • Journal of the Formosan Medical Association, January 2019, Elsevier

    Professor and Director Yau-Huei Wei, Yau-Huei Wei

  8. Assessment of zero-valent iron-based nanotherapeutics for ferroptosis induction and resensitization strategy in cancer cells

    Article • Biomaterials Science, January 2019, Royal Society of Chemistry

    Professor and Director Yau-Huei Wei, Yau-Huei Wei

  9. Sirt3 is required in adipogenic differentiation of stem cells and plays a role in type 2 diabetes.

    Article • Free Radical Research, July 2018, Taylor & Francis

    Professor and Director Yau-Huei Wei, Yu-Ting Wu, Yau-Huei Wei

  10. Generation of two isogenic human induced pluripotent stem cell lines from a 15 year-old female patient with MERRF syndrome and A8344G mutation of mitochondrial DNA

    Article • Stem Cell Research, July 2018, Elsevier

    Professor and Director Yau-Huei Wei, Yau-Huei Wei, Professor Hsin-Chen Lee

  11. Essential role of connective tissue growth factor (CTGF) in transforming growth factor-β1 (TGF-β1)-induced myofibroblast transdifferentiation from Graves’ orbital fibroblasts

    Article • Scientific Reports, May 2018, Springer Science + Business Media

    Professor and Director Yau-Huei Wei, Yau-Huei Wei

  12. ATOH1/RFX1/RFX3 transcription factors facilitate the differentiation and characterisation of inner ear hair cell-like cells from patient-specific induced pluripotent stem cells harbouring A8344G mutation of mitochondrial DNA

    Article • Cell Death and Disease, April 2018, Springer Science + Business Media

    Professor and Director Yau-Huei Wei, Yau-Huei Wei

  13. Sirt3 activates mitochondrial enzymes and antioxidant defense in differentiating stem cells.

    Article • Experimental Biology and Medicine, March 2018, SAGE Publications

    Professor and Director Yau-Huei Wei, Yau-Huei Wei

  14. Connective tissue growth factor decreases mitochondrial metabolism through ubiquitin-mediated degradation of mitochondrial transcription factor A in oral squamous cell carcinoma

    Article • Journal of the Formosan Medical Association, March 2018, Elsevier

    Professor and Director Yau-Huei Wei, Yau-Huei Wei

  15. Generation of an induced pluripotent stem cell (iPSC) line from a 40-year-old patient with the A8344G mutation of mitochondrial DNA and MERRF (myoclonic epilepsy with ragged red fibers) syndrome

    Article • Stem Cell Research, March 2018, Elsevier

    Professor and Director Yau-Huei Wei, Yau-Huei Wei

  16. Promoter analysis and transcriptional regulation of human carbonic anhydrase VIII gene in a MERRF disease cell model

    Article • Archives of Biochemistry and Biophysics, March 2018, Elsevier

    Professor and Director Yau-Huei Wei, Yau-Huei Wei

  17. Generation of an induced pluripotent stem cell line from a 39-year-old female patient with severe-to-profound non-syndromic sensorineural hearing loss and a A1555G mutation in the mitochondrial MTRNR1 gene

    Article • Stem Cell Research, December 2017, Elsevier

    Professor and Director Yau-Huei Wei, Yau-Huei Wei

  18. Role of mitochondrial function in the invasiveness of human colon cancer cells

    Article • Oncology Reports, November 2017, Spandidos Publications

    Professor and Director Yau-Huei Wei, Yau-Huei Wei

  19. Role of mitochondrial dysfunction and dysregulation of Ca2+ homeostasis in the pathophysiology of insulin resistance and type 2 diabetes

    Article • Journal of Biomedical Science, September 2017, Springer Science + Business Media

    Professor and Director Yau-Huei Wei, Yau-Huei Wei

  20. Peptide-mediated delivery of donor mitochondria improves mitochondrial function and cell viability in human cybrid cells with the MELAS A3243G mutation

    Article • Scientific Reports, September 2017, Springer Science + Business Media

    Professor and Director Yau-Huei Wei, Yau-Huei Wei

  21. Inflexibility of AMPK-mediated metabolic reprogramming in mitochondrial disease

    Article • Oncotarget, September 2017, Impact Journals, LLC

    Yau-Huei Wei

  22. ROS and Oxidative Stress in Stem Cells

    Article • Oxidative Medicine and Cellular Longevity, January 2017, Hindawi Publishing Corporation

    Professor and Director Yau-Huei Wei, Professor Hsin-Chen Lee, Magdalena Skonieczna, Yau-Huei Wei

  23. Integrative therapy decreases the risk of lupus nephritis in patients with systemic lupus erythematosus: A population-based retrospective cohort study

    Article • Journal of Ethnopharmacology, January 2017, Elsevier

    Yau-Huei Wei

  24. The pathogenesis of systemic lupus erythematosus - From the viewpoint of oxidative stress and mitochondrial dysfunction

    Article • Mitochondrion, September 2016, Elsevier

    Professor and Director Yau-Huei Wei, Yau-Huei Wei

  25. Disruption of the human COQ5-containing protein complex is associated with diminished coenzyme Q10 levels under two different conditions of mitochondrial energy deficiency

    Article • Biochimica et Biophysica Acta (BBA) - General Subjects, September 2016, Elsevier

    Yau-Huei Wei

  26. Expression and clinical significance of connective tissue growth factor (CTGF) in Graves' ophthalmopathy

    Article • British Journal of Ophthalmology, August 2016, BMJ

    Professor and Director Yau-Huei Wei, Yau-Huei Wei

  27. Hyaluronan Upregulates Mitochondrial Biogenesis and Reduces Adenoside Triphosphate Production for Efficient Mitochondrial Function in Slow-Proliferating Human Mesenchymal Stem Cells

    Article • Stem Cells, July 2016, Wiley

    Professor Lynn LH Huang, Professor and Director Yau-Huei Wei, Yau-Huei Wei

  28. Role of Mitochondrial DNA Copy Number Alteration in Human Renal Cell Carcinoma

    Article • International Journal of Molecular Sciences, May 2016, MDPI AG

    Professor and Director Yau-Huei Wei, Yau-Huei Wei

  29. Mitochondria in mesenchymal stem cell biology and cell therapy: From cellular differentiation to mitochondrial transfer

    Article • Seminars in Cell and Developmental Biology, April 2016, Elsevier

    Professor and Director Yau-Huei Wei, Yau-Huei Wei

  30. Mitochondrial resetting and metabolic reprogramming in induced pluripotent stem cells and mitochondrial disease modeling

    Article • Biochimica et Biophysica Acta (BBA) - General Subjects, April 2016, Elsevier

    Yau-Huei Wei

  31. Allogeneic/xenogeneic transplantation of peptide-labeled mitochondria in Parkinson's disease: restoration of mitochondria functions and attenuation of 6-hydroxydopamine–induced neurotoxicity

    Article • Translational Research, April 2016, Elsevier

    Yau-Huei Wei

  32. Impaired ROS Scavenging System in Human Induced Pluripotent Stem Cells Generated from Patients with MERRF Syndrome

    Article • Scientific Reports, March 2016, Springer Science + Business Media

    Yau-Huei Wei, Professor Hsin-Chen Lee

  33. Cigarette Smoke Extract-Induced Oxidative Stress and Fibrosis-Related Genes Expression in Orbital Fibroblasts from Patients with Graves’ Ophthalmopathy

    Article • Oxidative Medicine and Cellular Longevity, January 2016, Hindawi Publishing Corporation

    Professor and Director Yau-Huei Wei, Yau-Huei Wei

  34. Alteration of Connective Tissue Growth Factor (CTGF) Expression in Orbital Fibroblasts from Patients with Graves’ Ophthalmopathy

    Article • PLoS ONE, November 2015, PLOS

    Professor and Director Yau-Huei Wei, Yau-Huei Wei

  35. Depletion of mitoferrins leads to mitochondrial dysfunction and impairment of adipogenic differentiation in 3T3-L1 preadipocytes

    Article • Free Radical Research, August 2015, Taylor & Francis

    Yau-Huei Wei

  36. Role of mitochondrial dysfunction and dysregulation of Ca2+ homeostasis in insulin insensitivity of mammalian cells

    Article • Annals of the New York Academy of Sciences, July 2015, Wiley

    Yau-Huei Wei

  37. 2-Deoxy-d-Glucose Can Complement Doxorubicin and Sorafenib to Suppress the Growth of Papillary Thyroid Carcinoma Cells

    Article • PLoS ONE, July 2015, PLOS

    Professor and Director Yau-Huei Wei, Yau-Huei Wei

  38. The Core Pattern Analysis on Chinese Herbal Medicine for Sjögren's syndrome: A Nationwide Population-Based Study

    Article • Scientific Reports, April 2015, Nature

    Dr. Hung-Rong Yen, Professor and Director Yau-Huei Wei, Yau-Huei Wei

  39. Mitochondrial DNA alterations correlate with the pathological status and the immunological ER, PR, HER-2/neu, p53 and Ki-67 expression in breast invasive ductal carcinoma

    Article • Oncology Reports, March 2015, Spandidos Publications

    Yau-Huei Wei

  40. Bypassing the EPR effect with a nanomedicine harboring a sustained-release function allows better tumor control

    Article • International Journal of Nanomedicine, March 2015, Dove Medical Press

    Chun-Lin He, Yau-Huei Wei

  41. The Role of hOGG1 C1245G Polymorphism in the Susceptibility to Lupus Nephritis and Modulation of the Plasma 8-OHdG in Patients with Systemic Lupus Erythematosus

    Article • International Journal of Molecular Sciences, February 2015, MDPI AG

    Yau-Huei Wei

  42. Correlation of NADH fluorescence lifetime and oxidative phosphorylation metabolism in the osteogenic differentiation of human mesenchymal stem cell

    Article • Journal of Biomedical Optics, January 2015, SPIE

    Professor and Director Yau-Huei Wei, Yau-Huei Wei

  43. Transient Increase in Circulating Myeloid-Derived Suppressor Cells after Partial Bladder Outlet Obstruction

    Article • The Journal of Urology, November 2014, Wolters Kluwer Health

    Professor and Director Yau-Huei Wei, Yau-Huei Wei

  44. Metabolic reprogramming orchestrates cancer stem cell properties in nasopharyngeal carcinoma

    Article • Cell Cycle, October 2014, Taylor & Francis

    Yau-Huei Wei

  45. Metabolic Reprogramming of Human Cells in Response to Oxidative Stress: Implications in the Pathophysiology and Therapy of Mitochondrial Diseases

    Article • Current Pharmaceutical Design, September 2014, Bentham Science Publishers

    Yau-Huei Wei

  46. Differential patterns of effects of age and sex on metabolic syndrome in Taiwan: Implication for the inadequate internal consistency of the current criteria

    Article • Diabetes Research and Clinical Practice, August 2014, Elsevier

    Professor and Director Yau-Huei Wei, Yau-Huei Wei

  47. Cisd2 mediates lifespan: is there an interconnection among Ca2+homeostasis, autophagy, and lifespan?

    Article • Free Radical Research, July 2014, Taylor & Francis

    Professor and Director Yau-Huei Wei, Yau-Huei Wei

  48. Roles of sirtuins in the regulation of antioxidant defense and bioenergetic function of mitochondria under oxidative stress

    Article • Free Radical Research, July 2014, Taylor & Francis

    Professor and Director Yau-Huei Wei, Yau-Huei Wei

  49. Cisd2 modulates the differentiation and functioning of adipocytes by regulating intracellular Ca2+ homeostasis

    Article • Human Molecular Genetics, May 2014, Oxford University Press (OUP)

    Professor and Director Yau-Huei Wei, Yau-Huei Wei

  50. Effects of carbonic anhydrase-related protein VIII on human cells harbouring an A8344G mitochondrial DNA mutation

    Article • Biochemical Journal, April 2014, Portland Press Ltd.

    Professor and Director Yau-Huei Wei, Yau-Huei Wei

  51. Role of AMPK-mediated adaptive responses in human cells with mitochondrial dysfunction to oxidative stress

    Article • Biochimica et Biophysica Acta (BBA) - General Subjects, April 2014, Elsevier

    Professor and Director Yau-Huei Wei, Yau-Huei Wei

  52. Increased 8-hydroxy-2′-deoxyguanosine in plasma and decreased mRNA expression of human 8-oxoguanine DNA glycosylase 1, anti-oxidant enzymes, mitochondrial biogenesis-related proteins and glycolytic enzymes in leucocytes in patients with systemic lupus ery

    Article • Clinical & Experimental Immunology, March 2014, Wiley

    Chang-Youh Tsai, Yau-Huei Wei

  53. Mitochondrial DNA association study of type 2 diabetes with or without ischemic stroke in Taiwan

    Article • BMC Research Notes, January 2014, Springer Science + Business Media

    Professor and Director Yau-Huei Wei, Yau-Huei Wei

  54. Inhibitory Effects of Hypoxia on Metabolic Switch and Osteogenic Differentiation of Human Mesenchymal Stem Cells

    Article • Stem Cells, December 2013, Oxford University Press (OUP)

    Yau-Huei Wei, Professor and Director Yau-Huei Wei

  55. The Emerging Role of SOX2 in Cell Proliferation and Survival and Its Crosstalk with Oncogenic Signaling in Lung Cancer

    Article • Stem Cells, December 2013, Wiley

    Yau-Huei Wei

  56. Treatment of human cells derived from MERRF syndrome by peptide-mediated mitochondrial delivery

    Article • Cytotherapy, December 2013, Elsevier

    Yau-Huei Wei

  57. Integrated three-dimensional system-on-chip for direct quantitative detection of mitochondrial DNA mutation in affected cells

    Article • Biosensors and Bioelectronics, October 2013, Elsevier

    Professor and Director Yau-Huei Wei, Yau-Huei Wei

  58. Mitochondrial dysfunction represses HIF-1α protein synthesis through AMPK activation in human hepatoma HepG2 cells

    Article • Biochimica et Biophysica Acta (BBA) - General Subjects, October 2013, Elsevier

    Yau-Huei Wei, Professor Hsin-Chen Lee

  59. Isolation and Characterization of a Novel Strain of Mesenchymal Stem Cells from Mouse Umbilical Cord: Potential Application in Cell-Based Therapy

    Article • PLoS ONE, August 2013, PLOS

    Professor and Director Yau-Huei Wei, Yau-Huei Wei

  60. Involvement of mtDNA Damage Elicited by Oxidative Stress in the Arsenical Skin Cancers

    Article • Journal of Investigative Dermatology, July 2013, Elsevier

    Yau-Huei Wei

  61. Oxidative stress response elicited by mitochondrial dysfunction: Implication in the pathophysiology of aging

    Article • Experimental Biology and Medicine, May 2013, SAGE Publications

    Yau-Huei Wei

  62. Cadmium-Based Quantum Dot Induced Autophagy Formation for Cell Survival via Oxidative Stress

    Article • Chemical Research in Toxicology, April 2013, American Chemical Society (ACS)

    Yau-Huei Wei

  63. Molecular Mechanisms of UV-Induced Apoptosis and Its Effects on Skin Residential Cells: The Implication in UV-Based Phototherapy

    Article • International Journal of Molecular Sciences, March 2013, MDPI AG

    Yau-Huei Wei

  64. Perfusion status of the stroke-like lesion at the hyperacute stage in MELAS

    Article • Brain and Development, February 2013, Elsevier

    Yau-Huei Wei

  65. Mitochondrial dysfunction leads to impairment of insulin sensitivity and adiponectin secretion in adipocytes

    Article • FEBS Journal, January 2013, Wiley

    Yau-Huei Wei

  66. Resveratrol Impedes the Stemness, Epithelial-Mesenchymal Transition, and Metabolic Reprogramming of Cancer Stem Cells in Nasopharyngeal Carcinoma through p53 Activation

    Article • Evidence-based Complementary and Alternative Medicine, January 2013, Hindawi Publishing Corporation

    Professor and Director Yau-Huei Wei, Yau-Huei Wei

  67. Mitochondrial DNA alterations and mitochondrial dysfunction in the progression of hepatocellular carcinoma

    Article • World Journal of Gastroenterology, January 2013, Baishideng Publishing Group Co., Limited (formerly WJG Press)

    Yau-Huei Wei, Professor Hsin-Chen Lee

  68. Regulation of mitochondrial FoF1ATPase activity by Sirt3-catalyzed deacetylation and its deficiency in human cells harboring 4977bp deletion of mitochondrial DNA

    Article • Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, January 2013, Elsevier

    Yau-Huei Wei, Professor Hsin-Chen Lee

  69. Effects of Intravascular Laser Irradiation of Blood in Mitochondria Dysfunction and Oxidative Stress in Adults with Chronic Spinal Cord Injury

    Article • Photomedicine and Laser Surgery, October 2012, Mary Ann Liebert Inc

    Yau-Huei Wei

  70. Functional Recovery of Human Cells Harbouring the Mitochondrial DNA Mutation MERRF A8344G via Peptide-Mediated Mitochondrial Delivery

    Article • Neurosignals, September 2012, Karger Publishers

    Professor and Director Yau-Huei Wei, Yau-Huei Wei

  71. High Mitochondrial DNA Copy Number and Bioenergetic Function Are Associated with Tumor Invasion of Esophageal Squamous Cell Carcinoma Cell Lines

    Article • International Journal of Molecular Sciences, September 2012, MDPI AG

    Professor and Director Yau-Huei Wei, Yau-Huei Wei

  72. Cigarette Smoking and hOGG1 Ser326Cys Polymorphism are Associated with 8-OHdG Accumulation on Mitochondrial DNA in Thoracic Esophageal Squamous Cell Carcinoma

    Article • Annals of Surgical Oncology, September 2012, Springer Science + Business Media

    Professor and Director Yau-Huei Wei, Yau-Huei Wei

  73. Prognosis of symptomatic patients with the A3243G mutation of mitochondrial DNA

    Article • Journal of the Formosan Medical Association, September 2012, Elsevier

    Yau-Huei Wei

  74. The protective roles of phosphorylated heat shock protein 27 in human cells harboring myoclonus epilepsy with ragged-red fibers A8344G mtDNA mutation

    Article • FEBS Journal, July 2012, Wiley

    Yau-Huei Wei

  75. Leukocyte Mitochondrial DNA Alteration in Systemic Lupus Erythematosus and Its Relevance to the Susceptibility to Lupus Nephritis

    Article • International Journal of Molecular Sciences, July 2012, MDPI AG

    Professor and Director Yau-Huei Wei, Yau-Huei Wei

  76. Electronic microscopy evidence for mitochondria as targets for Cd/Se/Te-based quantum dot 705 toxicity in vivo

    Article • The Kaohsiung Journal of Medical Sciences, July 2012, Wiley

    Yau-Huei Wei

  77. The role of cytochrome c oxidase subunit Va in non-small cell lung carcinoma cells: association with migration, invasion and prediction of distant metastasis

    Article • BMC Cancer, June 2012, Springer Science + Business Media

    Yau-Huei Wei

  78. A persistent level of Cisd2 extends healthy lifespan and delays aging in mice

    Article • Human Molecular Genetics, June 2012, Oxford University Press (OUP)

    Yau-Huei Wei

  79. Reversing bladder outlet obstruction attenuates systemic and tissue oxidative stress

    Article • BJU International, May 2012, Wiley

    Yau-Huei Wei

  80. Mitochondrial bioenergetic function and metabolic plasticity in stem cell differentiation and cellular reprogramming

    Article • Biochimica et Biophysica Acta (BBA) - General Subjects, May 2012, Elsevier

    Professor and Director Yau-Huei Wei, Yau-Huei Wei

  81. Associated microsatellite alterations in mitochondrial DNA and in TP53 in thoracic esophageal squamous cell carcinoma

    Article • Oncology Reports, April 2012, Spandidos Publications

    Professor and Director Yau-Huei Wei, Yau-Huei Wei

  82. AMPK-mediated increase of glycolysis as an adaptive response to oxidative stress in human cells: Implication of the cell survival in mitochondrial diseases

    Article • Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, February 2012, Elsevier

    Professor and Director Yau-Huei Wei, Yau-Huei Wei

  83. Induction of primitive pigment cell differentiation by visible light (helium–neon laser): a photoacceptor-specific response not replicable by UVB irradiation

    Article • Journal of Molecular Medicine, October 2011, Springer Science + Business Media

    Professor and Director Yau-Huei Wei, Yau-Huei Wei

  84. Decreased heat shock protein 27 expression and altered autophagy in human cells harboring A8344G mitochondrial DNA mutation

    Article • Mitochondrion, September 2011, Elsevier

    Yau-Huei Wei

  85. The Effect of Photo-oxidative Stress and Inflammatory Cytokine on Complement Factor H Expression in Retinal Pigment Epithelial Cells

    Article • Investigative Ophthalmology & Visual Science, August 2011, Association for Research in Vision and Ophthalmology (ARVO)

    Professor and Director Yau-Huei Wei, Yau-Huei Wei

  86. Increased penile expression of transforming growth factor and elevated systemic oxidative stress in rabbits with chronic partial bladder outlet obstruction

    Article • International Journal of Andrology, June 2011, Wiley

    Professor and Director Yau-Huei Wei, Yau-Huei Wei

  87. Aberrant Cell Proliferation by Enhanced Mitochondrial Biogenesis via mtTFA in Arsenical Skin Cancers

    Article • American Journal Of Pathology, May 2011, Elsevier

    Professor and Director Yau-Huei Wei, Yau-Huei Wei

  88. Increase of reduced nicotinamide adenine dinucleotide fluorescence lifetime precedes mitochondrial dysfunction in staurosporine-induced apoptosis of HeLa cells

    Article • Journal of Biomedical Optics, January 2011, SPIE

    Professor and Director Yau-Huei Wei, Yau-Huei Wei

  89. Reduced nicotinamide adenine dinucleotide fluorescence lifetime detected poly(adenosine-5ʹ-diphosphate-ribose) polymerase-1-mediated cell death and therapeutic effect of pyruvate

    Article • Journal of Biomedical Optics, January 2011, SPIE

    Yau-Huei Wei

  90. Oxidative stress biomarkers in urine and plasma of rabbits with partial bladder outlet obstruction

    Article • BJU International, September 2010, Wiley

    Professor and Director Yau-Huei Wei, Yau-Huei Wei