All Stories

  1. Structural Basis for (2R,3R)-Taxifolin Binding and Reaction Products to the Bacterial Chalcone Isomerase of Eubacterium ramulus

    Article • Molecules, November 2022, MDPI AG

    Winfried Hinrichs

  2. Crystal structures of free and ligand‐bound forms of the TetR/AcrR‐like regulator SCO3201 from Streptomyces coelicolor suggest a novel allosteric mechanism

    Article • FEBS Journal, September 2022, Wiley

    Winfried Hinrichs

  3. Antiviral activity of natural phenolic compounds in complex at an allosteric site of SARS-CoV-2 papain-like protease

    Article • Communications Biology, August 2022, Springer Science + Business Media

    Winfried Hinrichs

  4. Hydrazones and Thiosemicarbazones Targeting Protein-Protein-Interactions of SARS-CoV-2 Papain-like Protease

    Article • Frontiers in Chemistry, April 2022, Frontiers

    Winfried Hinrichs

  5. Structural basis to repurpose boron-based proteasome inhibitors Bortezomib and Ixazomib as β-lactamase inhibitors

    Article • Scientific Reports, April 2022, Springer Science + Business Media

    Winfried Hinrichs

  6. The induction mechanism of the flavonoid‐responsive regulator FrrA

    Article • FEBS Journal, August 2021, Wiley

    Winfried Hinrichs

  7. The Komagataeibacter europaeus GqqA is the prototype of a novel bifunctional N-Acyl-homoserine lactone acylase with prephenate dehydratase activity

    Article • Scientific Reports, June 2021, Springer Science + Business Media

    Winfried Hinrichs

  8. X-ray screening identifies active site and allosteric inhibitors of SARS-CoV-2 main protease

    Article • Science, May 2021, American Association for the Advancement of Science

    Professor Henry N Chapman, Winfried Hinrichs

  9. Thermodynamics, cooperativity and stability of the tetracycline repressor (TetR) upon tetracycline binding

    Article • Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, June 2020, Elsevier

    Winfried Hinrichs

  10. Structural and biochemical analysis of a phosin from Streptomyces chartreusis reveals a combined polyphosphate‐ and metal‐binding fold

    Article • FEBS Letters, June 2019, Wiley

    Winfried Hinrichs

  11. Protein binding to Tetracyclines: Inhibitor, Regulator, Substrate

    Article • Insights in Enzyme Research, January 2018, Scitechnol Biosoft Pvt. Ltd.

    Winfried Hinrichs

  12. Assemblins as maturational proteases in herpesviruses

    Article • Journal of General Virology, August 2017, Society for General Microbiology

    Winfried Hinrichs

  13. Blocking tetracycline destruction

    Article • Nature Chemical Biology, May 2017, Springer Science + Business Media

    Winfried Hinrichs

  14. Structural evidence of intramolecular propeptide inhibition of the aspzincin metalloendopeptidase AsaP1

    Article • FEBS Letters, September 2016, Wiley

    Winfried Hinrichs

  15. Modular organisation of inducer recognition and allostery in the tetracycline repressor

    Article • FEBS Journal, April 2016, Wiley

    Winfried Hinrichs

  16. Structural analysis and knock-out of a Burkholderia pseudomallei homolog of the eukaryotic transcription coactivator PC4

    Article • Gene, February 2016, Elsevier

    Winfried Hinrichs

  17. A Quantitative Real-Time RT-PCR Assay for the Detection ofVenezuelan equine encephalitis virusUtilizing a Universal Alphavirus Control RNA

    Article • BioMed Research International, January 2016, Hindawi Publishing Corporation

    Winfried Hinrichs

  18. Dimerization-Induced Allosteric Changes of the Oxyanion-Hole Loop Activate the Pseudorabies Virus Assemblin pUL26N, a Herpesvirus Serine Protease

    Article • PLoS Pathogens, July 2015, PLOS

    Winfried Hinrichs

  19. Structure and catalytic mechanism of the evolutionarily unique bacterial chalcone isomerase

    Article • Acta Crystallographica Section D Biological Crystallography, March 2015, International Union of Crystallography

    Winfried Hinrichs

  20. Tetracycline Repressor Allostery Does Not Depend on Divalent Metal Recognition

    Article • Biochemistry, December 2014, American Chemical Society (ACS)

    Winfried Hinrichs

  21. Structural and biochemical characterization of the dual substrate recognition of the (R)-selective amine transaminase fromAspergillus fumigatus

    Article • FEBS Journal, December 2014, Wiley

    Winfried Hinrichs, Prof. Uwe T Bornscheuer

  22. Post-translational modification and extended glycosylation pattern of a plant latex peroxidase of native source characterized by X-ray crystallography

    Article • FEBS Journal, August 2014, Wiley

    Winfried Hinrichs

  23. Structure and regulatory targets of SCO3201, a highly promiscuous TetR-like regulator of Streptomyces coelicolor M145

    Article • Biochemical and Biophysical Research Communications, July 2014, Elsevier

    Winfried Hinrichs

  24. Crystallographic characterization of the (R)-selective amine transaminase fromAspergillus fumigatus

    Article • Acta Crystallographica Section D Biological Crystallography, March 2014, International Union of Crystallography

    Winfried Hinrichs, Prof. Uwe T Bornscheuer

  25. Putative dioxygen-binding sites and recognition of tigecycline and minocycline in the tetracycline-degrading monooxygenase TetX

    Article • Acta Crystallographica Section D Biological Crystallography, August 2013, International Union of Crystallography

    Winfried Hinrichs

  26. Humanes α2-Makroglobulin - eine Variation der Venusfliegenfalle

    Article • Angewandte Chemie, April 2012, Wiley

    Winfried Hinrichs

  27. Recognition of Drug Degradation Products by Target Proteins: Isotetracycline Binding to Tet Repressor

    Article • Journal of Medicinal Chemistry, July 2011, American Chemical Society (ACS)

    Winfried Hinrichs

  28. Structural basis for a new tetracycline resistance mechanism relying on the TetX monooxygenase

    Article • FEBS Letters, March 2011, Wiley

    Winfried Hinrichs

  29. Nonantibiotic Properties of Tetracyclines: Structural Basis for Inhibition of Secretory Phospholipase A2

    Article • Journal of Molecular Biology, April 2010, Elsevier

    Winfried Hinrichs

  30. Tetracycline-Tet Repressor Binding Specificity: Insights from Experiments and Simulations

    Article • Biophysical Journal, November 2009, Elsevier

    Winfried Hinrichs

  31. Tryptophan π-Electron System Capping a Copper(I) Binding Site-A New Organometallic Bonding Mode in Proteins

    Article • ChemBioChem, August 2008, Wiley

    Winfried Hinrichs

  32. Tryptophan π‐Electron System Capping a Copper(I) Binding Site—A New Organometallic Bonding Mode in Proteins

    Article • ChemBioChem, July 2008, Wiley

    Winfried Hinrichs

  33. Protonation Patterns in Tetracycline:Tet Repressor Recognition: Simulations and Experiments

    Article • ChemBioChem, April 2007, Wiley

    Winfried Hinrichs

  34. Old Codons, New Amino Acids

    Article • ChemInform, June 2004, Wiley

    Winfried Hinrichs

  35. Alte Codons– neue Aminosäuren

    Article • Angewandte Chemie, February 2004, Wiley

    Winfried Hinrichs

  36. Old Codons, New Amino Acids

    Article • Angewandte Chemie International Edition, February 2004, Wiley

    Winfried Hinrichs

  37. How Unique Is the Genetic Code

    Article • ChemInform, May 2003, Wiley

    Winfried Hinrichs

  38. Wie eindeutig ist der genetische Code?

    Article • Angewandte Chemie, February 2003, Wiley

    Winfried Hinrichs

  39. How Unique Is the Genetic Code?

    Article • Angewandte Chemie International Edition, February 2003, Wiley

    Winfried Hinrichs

  40. Gene regulation by the tetracycline-inducible Tet repressor-operator system — molecular mechanisms at atomic resolution

    Article • January 2001, Springer Science + Business Media

    Winfried Hinrichs

  41. ChemInform Abstract: The Tetracycline Repressor - A Paradigm for a Biological Switch

    Article • ChemInform, September 2000, Wiley

    Winfried Hinrichs

  42. Der Tetracyclin-Repressor – das Musterbeispiel für einen biologischen Schalter

    Article • Angewandte Chemie, June 2000, Wiley

    Winfried Hinrichs

  43. SELFSTACKING SYSTEMS, PART 6.1HOST LATTICE FUNCTION OF 2,3,8,9-TETRAMETHOXYDIBENZO[c,e][1,2]-DICHALCOGENINS IN THEIR ELECTRICALLY CONDUCTING IODINE COMPLEXES

    Article • Phosphorus Sulfur and Silicon and the Related Elements, April 1995, Taylor & Francis

    Winfried Hinrichs

  44. Structure of the Tet Repressor-tetracycline Complex and Regulation of Antibiotic Resistance

    Article • Science, April 1994, American Association for the Advancement of Science

    Winfried Hinrichs

  45. The structure of the left-handed antiparallel amylose double helix: Theoretical studies

    Article • Biopolymers, March 1993, Wiley

    Winfried Hinrichs

  46. Three-dimensional structure of system I of photosynthesis at 6 Å resolution

    Article • Nature, January 1993, Springer Science + Business Media

    Winfried Hinrichs

  47. Long-range structural changes in proteinase K triggered by calcium ion removal

    Article • Nature, February 1989, Springer Science + Business Media

    Winfried Hinrichs

  48. An Amylose Antiparallel Double Helix at Atomic Resolution

    Article • Science, October 1987, American Association for the Advancement of Science

    Winfried Hinrichs