All Stories

  1. BMP4 and Temozolomide Synergize in the Majority of Patient-Derived Glioblastoma Cultures

    Article • International Journal of Molecular Sciences, September 2024, MDPI AG

    Dr ir Wilfred van IJcken

  2. Butyrate selectively targets super-enhancers and transcriptional networks associated with human mast cell function

    Article • September 2024, Authorea, Inc.

    Dr ir Wilfred van IJcken

  3. Human Pluripotent Stem Cell-Derived Astrocyte Functionality Compares Favorably with Primary Rat Astrocytes

    Article • eNeuro, September 2024, Society for Neuroscience

    Dr ir Wilfred van IJcken

  4. Genome-wide methylation analysis in patients with proximal hypospadias – a pilot study and review of the literature

    Article • Epigenetics, August 2024, Taylor & Francis

    Dr ir Wilfred van IJcken

  5. A cellular reporter system to evaluate endogenous fetal hemoglobin induction and screen for therapeutic compounds

    Article • HemaSphere, August 2024, Wiley

    Dr ir Wilfred van IJcken

  6. The Cellular Origin of the Pulmonary Pericyte

    Article • July 2024, Springer Science + Business Media

    Dr ir Wilfred van IJcken

  7. DNA methylation database for gynecological cancer detection, classification and assay development

    Article • July 2024, Cold Spring Harbor Laboratory Press

    Dr ir Wilfred van IJcken

  8. Epigenomic partitioning of a polygenic risk score for asthma reveals distinct genetically driven disease pathways

    Article • European Respiratory Journal, June 2024, European Respiratory Society (ERS)

    Dr ir Wilfred van IJcken

  9. Unraveling the impact of AXIN1 mutations on HCC development: Insights from CRISPR/Cas9 repaired AXIN1-mutant liver cancer cell lines

    Article • PLoS ONE, June 2024, PLOS

    Dr ir Wilfred van IJcken

  10. Epigenetic and Genomic Hallmarks of PARP-Inhibitor Resistance in Ovarian Cancer Patients

    Article • Genes, June 2024, MDPI AG

    Dr ir Wilfred van IJcken

  11. Split Pool Ligation-based Single-cell Transcriptome sequencing (SPLiT-seq) data processing pipeline comparison

    Article • BMC Genomics, April 2024, Springer Science + Business Media

    Dr ir Wilfred van IJcken

  12. Species-specific responses during Seoul orthohantavirus infection in human and rat lung microvascular endothelial cells

    Article • PLoS Neglected Tropical Diseases, March 2024, PLOS

    Dr ir Wilfred van IJcken

  13. Distinctive cell‐free DNA methylation characterizes presymptomatic genetic frontotemporal dementia

    Article • Annals of Clinical and Translational Neurology, March 2024, Wiley

    Dr ir Wilfred van IJcken

  14. Runx1+ vascular smooth muscle cells are essential for hematopoietic stem and progenitor cell development in vivo

    Article • Nature Communications, February 2024, Springer Science + Business Media

    Dr ir Wilfred van IJcken

  15. A three-dimensional vessel-on-chip model to study Puumala orthohantavirus pathogenesis

    Article • Lab on a Chip, January 2024, Royal Society of Chemistry

    Dr ir Wilfred van IJcken

  16. Comparison of Single Cell Transcriptome Sequencing Methods: Of Mice and Men

    Article • Genes, December 2023, MDPI AG

    Dr ir Wilfred van IJcken

  17. Single-Cell RNA Sequencing of Donor-Reactive T Cells Reveals Role of Apoptosis in Donor-Specific Hyporesponsiveness of Kidney Transplant Recipients

    Article • International Journal of Molecular Sciences, September 2023, MDPI AG

    Dr ir Wilfred van IJcken

  18. Liquid Biopsies for Colorectal Cancer and Advanced Adenoma Screening and Surveillance: What to Measure?

    Article • Cancers, September 2023, MDPI AG

    Dr ir Wilfred van IJcken

  19. Phenotypic differences in resistance to thyroid hormone alpha: differential recruitment of cofactors by thyroid hormone receptor alpha 1 mutants

    Article • Endocrine Abstracts, August 2023, Bioscientifica

    Dr ir Wilfred van IJcken

  20. Mutation Analysis of Pancreatic Juice and Plasma for the Detection of Pancreatic Cancer

    Article • International Journal of Molecular Sciences, August 2023, MDPI AG

    Dr ir Wilfred van IJcken

  21. 3D chromatin reprogramming primes human memory T H 2 cells for rapid recall and pathogenic dysfunction

    Article • Science Immunology, July 2023, American Association for the Advancement of Science

    Dr ir Wilfred van IJcken

  22. Targeted Genomic Sequencing of TSC1 and TSC2 Reveals Causal Variants in Individuals for Whom Previous Genetic Testing for Tuberous Sclerosis Complex Was Normal

    Article • Human Mutation, July 2023, Hindawi Publishing Corporation

    Dr ir Wilfred van IJcken

  23. Machine learning-based somatic variant calling in cell-free DNA of metastatic breast cancer patients using large NGS panels

    Article • Scientific Reports, June 2023, Springer Science + Business Media

    Dr ir Wilfred van IJcken

  24. PD-L1 checkpoint blockade promotes regulatory T cell activity that underlies therapy resistance

    Article • Science Immunology, May 2023, American Association for the Advancement of Science

    Dr ir Wilfred van IJcken

  25. Genome-wide analysis toward the epigenetic aetiology of myelodysplastic syndrome disease progression and pharmacoepigenomic basis of hypomethylating agents drug treatment response

    Article • Human Genomics, April 2023, Springer Science + Business Media

    Dr ir Wilfred van IJcken

  26. Zeb2 DNA-Binding Sites in Neuroprogenitor Cells Reveal Autoregulation and Affirm Neurodevelopmental Defects, Including in Mowat-Wilson Syndrome

    Article • Genes, March 2023, MDPI AG

    Dr ir Wilfred van IJcken

  27. Retrospective analysis of enhancer activity and transcriptome history

    Article • Nature Biotechnology, February 2023, Springer Science + Business Media

    Dr ir Wilfred van IJcken

  28. Exploring the Interspecific Interactions and the Metabolome of the Soil Isolate Hylemonella gracilis

    Article • mSystems, February 2023, ASM Journals

    Dr ir Wilfred van IJcken

  29. Rabies virus uniquely reprograms the transcriptome of human monocyte-derived macrophages

    Article • Frontiers in Cellular and Infection Microbiology, January 2023, Frontiers

    Dr ir Wilfred van IJcken

  30. CABA-V7: a prospective biomarker selected trial of cabazitaxel treatment in AR-V7 positive prostate cancer patients

    Article • European Journal of Cancer, December 2022, Elsevier

    Dr ir Wilfred van IJcken

  31. USP7 regulates the ncPRC1 Polycomb axis to stimulate genomic H2AK119ub1 deposition uncoupled from H3K27me3

    Article • Science Advances, November 2022, American Association for the Advancement of Science

    Dr ir Wilfred van IJcken

  32. A kinase inhibitor screen reveals MEK1/2 as a novel therapeutic target to antagonize IGF1R-mediated antiestrogen resistance in ERα-positive luminal breast cancer

    Article • Biochemical Pharmacology, October 2022, Elsevier

    Dr ir Wilfred van IJcken

  33. Bio-distribution and longevity of mesenchymal stromal cell derived membrane particles

    Article • Journal of Controlled Release, October 2022, Elsevier

    Dr ir Wilfred van IJcken

  34. Molecular and behavioral consequences of Ube3a gene overdosage in mice

    Article • JCI Insight, September 2022, American Society for Clinical Investigation

    Dr ir Wilfred van IJcken

  35. Effect of bovine milk fat-based infant formulae on microbiota, metabolites and stool parameters in healthy term infants in a randomized, crossover, placebo-controlled trial

    Article • BMC Nutrition, August 2022, Springer Science + Business Media

    Dr ir Wilfred van IJcken

  36. Rapid specification of human pluripotent stem cells to functional astrocytes

    Article • August 2022, Cold Spring Harbor Laboratory Press

    Dr ir Wilfred van IJcken

  37. Identification of candidate enhancers controlling the transcriptome during the formation of interphalangeal joints

    Article • Scientific Reports, July 2022, Springer Science + Business Media

    Dr ir Wilfred van IJcken

  38. A multiplex pedigree with pathologically confirmed multiple system atrophy and Parkinson’s disease with dementia

    Article • Brain Communications, July 2022, Oxford University Press (OUP)

    Dr ir Wilfred van IJcken

  39. PDGFRβ+ cells play a dual role as hematopoietic precursors and niche cells during mouse ontogeny

    Article • Cell Reports, July 2022, Elsevier

    Dr ir Wilfred van IJcken

  40. Dominant-acting CSF1R variants cause microglial depletion and altered astrocytic phenotype in zebrafish and adult-onset leukodystrophy

    Article • Acta Neuropathologica, June 2022, Springer Science + Business Media

    Dr ir Wilfred van IJcken

  41. JMJD3 intrinsically disordered region links the 3D-genome structure to TGFβ-dependent transcription activation

    Article • Nature Communications, June 2022, Springer Science + Business Media

    Dr ir Wilfred van IJcken

  42. Comparative single-cell RNA-sequencing profiling of BMP4-treated primary glioma cultures reveals therapeutic markers

    Article • Neuro-Oncology, May 2022, Oxford University Press (OUP)

    Dr ir Wilfred van IJcken

  43. CRISPRs in the human genome are differentially expressed between malignant and normal adjacent to tumor tissue

    Article • Communications Biology, April 2022, Springer Science + Business Media

    Dr ir Wilfred van IJcken

  44. Temozolomide and Radiotherapy versus Radiotherapy Alone in Patients with Glioblastoma, IDH-wildtype: Post Hoc Analysis of the EORTC Randomized Phase III CATNON Trial

    Article • Clinical Cancer Research, March 2022, American Association for Cancer Research (AACR)

    Dr ir Wilfred van IJcken

  45. Genetic and epigenetic determinants of reactivation of Mecp2 and the inactive X chromosome in neural stem cells

    Article • Stem Cell Reports, March 2022, Elsevier

    Dr ir Wilfred van IJcken

  46. Kidney Organoids Are Capable of Forming Tumors, but Not Teratomas

    Article • Stem Cells, February 2022, Oxford University Press (OUP)

    Dr ir Wilfred van IJcken

  47. NOXA expression drives synthetic lethality to RUNX1 inhibition in pancreatic cancer

    Article • Proceedings of the National Academy of Sciences, February 2022, Proceedings of the National Academy of Sciences

    Matthias Wirth, Dr ir Wilfred van IJcken

  48. Unraveling the Genetics of Congenital Diaphragmatic Hernia: An Ongoing Challenge

    Article • Frontiers in Pediatrics, February 2022, Frontiers

    Dr ir Wilfred van IJcken

  49. Epigenomic analysis of KLF1 haploinsufficiency in primary human erythroblasts

    Article • Scientific Reports, January 2022, Springer Science + Business Media

    Dr ir Wilfred van IJcken

  50. Genome-wide aberrant methylation in primary metastatic UM and their matched metastases

    Article • Scientific Reports, January 2022, Springer Science + Business Media

    Dr ir Wilfred van IJcken

  51. Combined Analysis of Transcriptome and T-Cell Receptor Alpha and Beta (TRA/TRB) Repertoire in Paucicellular Samples at the Single-Cell Level

    Article • January 2022, Springer Science + Business Media

    Dr ir Wilfred van IJcken

  52. Multi-Omics Profiling in Marfan Syndrome: Further Insights into the Molecular Mechanisms Involved in Aortic Disease

    Article • International Journal of Molecular Sciences, December 2021, MDPI AG

    Dr ir Wilfred van IJcken

  53. SPEN is required for Xist upregulation during initiation of X chromosome inactivation

    Article • Nature Communications, December 2021, Springer Science + Business Media

    Dr ir Wilfred van IJcken

  54. The Somatic Mutation Paradigm in Congenital Malformations: Hirschsprung Disease as a Model

    Article • International Journal of Molecular Sciences, November 2021, MDPI AG

    Dr ir Wilfred van IJcken

  55. The tumor suppressor MIR139 is silenced by POLR2M to promote AML oncogenesis

    Article • Leukemia, November 2021, Springer Science + Business Media

    Dr ir Wilfred van IJcken

  56. RMplex: An efficient method for analyzing 30 Y-STRs with high mutation rates

    Article • Forensic Science International Genetics, November 2021, Elsevier

    Dr ir Wilfred van IJcken

  57. High-throughput and affordable genome-wide methylation profiling of circulating cell-free DNA by methylated DNA sequencing (MeD-seq) of LpnPI digested fragments

    Article • Clinical Epigenetics, October 2021, Springer Science + Business Media

    Dr ir Wilfred van IJcken

  58. Heritability and De Novo Mutations in Oesophageal Atresia and Tracheoesophageal Fistula Aetiology

    Article • Genes, October 2021, MDPI AG

    Dr ir Wilfred van IJcken

  59. Enhancer-associated H3K4 methylation safeguards in vitro germline competence

    Article • Nature Communications, October 2021, Springer Science + Business Media

    Dr ir Wilfred van IJcken

  60. Identification of SPRY4 as a Novel Candidate Susceptibility Gene for Familial Nonmedullary Thyroid Cancer

    Article • Thyroid, September 2021, Mary Ann Liebert Inc

    Dr ir Wilfred van IJcken

  61. CTCF chromatin residence time controls three-dimensional genome organization, gene expression and DNA methylation in pluripotent cells

    Article • Nature Cell Biology, July 2021, Springer Science + Business Media

    Dr ir Wilfred van IJcken

  62. Genome wide DNA methylation analysis of alveolar capillary dysplasia lung tissue reveals aberrant methylation of genes involved in development including the FOXF1 locus

    Article • Clinical Epigenetics, July 2021, Springer Science + Business Media

    Dr ir Wilfred van IJcken

  63. High throughput and affordable genome-wide methylation profiling of circulating cell-free DNA by Methylated DNA sequencing (MeD-seq) of LpnPI digested fragments

    Article • July 2021, Cold Spring Harbor Laboratory Press

    Dr ir Wilfred van IJcken

  64. Zeb2 DNA-binding sites in neuroprogenitor cells reveal autoregulation and affirm neurodevelopmental defects, including in Mowat-Wilson Syndrome

    Article • July 2021, Cold Spring Harbor Laboratory Press

    Dr ir Wilfred van IJcken

  65. Orphan CpG islands amplify poised enhancer regulatory activity and determine target gene responsiveness

    Article • Nature Genetics, June 2021, Springer Science + Business Media

    Dr ir Wilfred van IJcken

  66. Molecular analysis of the erythroid phenotype of a patient with BCL11A haploinsufficiency

    Article • Blood Advances, May 2021, American Society of Hematology

    Dr ir Wilfred van IJcken

  67. Selective cell death in HIV-1-infected cells by DDX3 inhibitors leads to depletion of the inducible reservoir

    Article • Nature Communications, April 2021, Springer Science + Business Media

    Dr ir Wilfred van IJcken

  68. Prognostic significance of genome-wide DNA methylation profiles within the randomized, phase 3, EORTC CATNON trial on non-1p/19q deleted anaplastic glioma

    Article • Neuro-Oncology, April 2021, Oxford University Press (OUP)

    Dr ir Wilfred van IJcken

  69. Endothelial Zeb2 preserves the hepatic angioarchitecture and protects against liver fibrosis

    Article • Cardiovascular Research, April 2021, Oxford University Press (OUP)

    Dr ir Wilfred van IJcken

  70. Forkhead Box F1 as a mediator of Wnt signaling in human lung endothelial cells

    Article • March 2021, European Respiratory Society (ERS)

    Dr ir Wilfred van IJcken

  71. Interplay between FLI-1 and the LDB1 complex in murine erythroleukemia cells and during megakaryopoiesis

    Article • iScience, March 2021, Elsevier

    Dr ir Wilfred van IJcken

  72. Genetic and epigenetic determinants of reactivation of Mecp2 and the inactive X chromosome in neural stem cells

    Article • February 2021, Cold Spring Harbor Laboratory Press

    Dr ir Wilfred van IJcken

  73. Exploring the interspecific interactions and the metabolome of the soil isolateHylemonella gracilis

    Article • February 2021, Cold Spring Harbor Laboratory Press

    Dr ir Wilfred van IJcken

  74. Steroid-resistant human inflammatory ILC2s are marked by CD45RO and elevated in type 2 respiratory diseases

    Article • Science Immunology, January 2021, American Association for the Advancement of Science

    Dr ir Wilfred van IJcken

  75. CirculatingTP53mutations are associated with early tumor progression and poor survival in pancreatic cancer patients treated with FOLFIRINOX

    Article • Therapeutic Advances in Medical Oncology, January 2021, SAGE Publications

    Dr ir Wilfred van IJcken

  76. Low Input Targeted Chromatin Capture (Low-T2C)

    Article • January 2021, Springer Science + Business Media

    Dr ir Wilfred van IJcken

  77. SPEN is Required forXistUpregulation during Initiation of X Chromosome Inactivation

    Article • December 2020, Cold Spring Harbor Laboratory Press

    Dr ir Wilfred van IJcken

  78. Comparison of the PU.1 transcriptional regulome and interactome in human and mouse inflammatory dendritic cells

    Article • Journal of Leukocyte Biology, December 2020, Oxford University Press (OUP)

    Dr ir Wilfred van IJcken

  79. The Bone-Forming Properties of Periosteum-Derived Cells Differ Between Harvest Sites

    Article • Frontiers in Cell and Developmental Biology, November 2020, Frontiers

    Dr ir Wilfred van IJcken

  80. Histological, immunohistochemical and transcriptomic characterization of human tracheoesophageal fistulas

    Article • PLoS ONE, November 2020, PLOS

    Dr ir Wilfred van IJcken

  81. Alveolar barrier disruption in varicella pneumonia is associated with neutrophil extracellular trap formation

    Article • JCI Insight, November 2020, American Society for Clinical Investigation

    Dr ir Wilfred van IJcken

  82. Differentially Methylated Regions in Desmoid-Type Fibromatosis: A Comparison Between CTNNB1 S45F and T41A Tumors

    Article • Frontiers in Oncology, October 2020, Frontiers

    Dr Erik A.C. Wiemer, Dr ir Wilfred van IJcken

  83. Validation of a Combined Transcriptome and T Cell Receptor Alpha/Beta (TRA/TRB) Repertoire Assay at the Single Cell Level for Paucicellular Samples

    Article • Frontiers in Immunology, August 2020, Frontiers

    Dr ir Wilfred van IJcken

  84. Induction of selective cell death in HIV-1-infected cells by DDX3 inhibitors leads to depletion of the inducible reservoir

    Article • August 2020, Cold Spring Harbor Laboratory Press

    Dr ir Wilfred van IJcken

  85. Gliotoxin, identified from a screen of fungal metabolites, disrupts 7SK snRNP, releases P-TEFb, and reverses HIV-1 latency

    Article • Science Advances, August 2020, American Association for the Advancement of Science

    Dr ir Wilfred van IJcken

  86. Hemolysis in the spleen drives erythrocyte turnover

    Article • Blood, August 2020, American Society of Hematology

    Dr ir Wilfred van IJcken

  87. Orphan CpG islands boost the regulatory activity of poised enhancers and dictate the responsiveness of their target genes

    Article • August 2020, Cold Spring Harbor Laboratory Press

    Dr ir Wilfred van IJcken

  88. Targeted chromatin conformation analysis identifies novel distal neural enhancers of ZEB2 in pluripotent stem cell differentiation

    Article • Human Molecular Genetics, July 2020, Oxford University Press (OUP)

    Dr ir Wilfred van IJcken

  89. p53 drives premature neuronal differentiation in response to radiation-induced DNA damage during early neurogenesis

    Article • June 2020, Cold Spring Harbor Laboratory Press

    Dr ir Wilfred van IJcken

  90. Rapid in vitro generation of bona fide exhausted CD8+ T cells is accompanied by Tcf7 promotor methylation

    Article • PLoS Pathogens, June 2020, PLOS

    Dr ir Wilfred van IJcken

  91. In vitro capture and characterization of embryonic rosette-stage pluripotency between naive and primed states

    Article • Nature Cell Biology, May 2020, Springer Science + Business Media

    Dr ir Wilfred van IJcken

  92. MAU2 and NIPBL Variants Impair the Heterodimerization of the Cohesin Loader Subunits and Cause Cornelia de Lange Syndrome

    Article • Cell Reports, May 2020, Elsevier

    Dr ir Wilfred van IJcken

  93. Exome Sequencing Analysis Identifies Rare Variants in ATM and RPL8 That Are Associated With Shorter Telomere Length

    Article • Frontiers in Genetics, April 2020, Frontiers

    Dr ir Wilfred van IJcken

  94. Butyrate inhibits human mast cell activation via epigenetic regulation of FcεRI‐mediated signaling

    Article • Allergy, April 2020, Wiley

    Dr ir Wilfred van IJcken

  95. Infantile hypertrophic pyloric stenosis in patients with esophageal atresia

    Article • Birth Defects Research, April 2020, Wiley

    Dr ir Wilfred van IJcken

  96. Notch signaling licenses allergic airway inflammation by promoting Th2 cell lymph node egress

    Article • Journal of Clinical Investigation, April 2020, American Society for Clinical Investigation

    Dr ir Wilfred van IJcken

  97. Redundant and specific roles of cohesin STAG subunits in chromatin looping and transcriptional control

    Article • Genome Research, April 2020, Cold Spring Harbor Laboratory Press

    Dr ir Wilfred van IJcken

  98. Cystic renal-epithelial derived induced pluripotent stem cells from polycystic kidney disease patients

    Article • Stem Cells Translational Medicine, March 2020, Oxford University Press (OUP)

    Dr ir Wilfred van IJcken

  99. MicroRNA expression and DNA methylation profiles do not distinguish between primary and recurrent well-differentiated liposarcoma

    Article • PLoS ONE, January 2020, PLOS

    Dr Erik A.C. Wiemer, Dr ir Wilfred van IJcken

  100. Multifaceted actions of Zeb2 in postnatal neurogenesis from the ventricular-subventricular zone to the olfactory bulb

    Article • Development, January 2020, The Company of Biologists

    Dr ir Wilfred van IJcken

  101. CREPT Promotes Melanoma Progression Through Accelerated Proliferation and Enhanced Migration by RhoA-Mediated Actin Filaments and Focal Adhesion Formation

    Article • Cancers, December 2019, MDPI AG

    Dr ir Wilfred van IJcken

  102. Loss of UGP2 in brain leads to a severe epileptic encephalopathy, emphasizing that bi-allelic isoform-specific start-loss mutations of essential genes can cause genetic diseases

    Article • Acta Neuropathologica, December 2019, Springer Science + Business Media

    Dr ir Wilfred van IJcken

  103. Characterization of the ferret TRB locus guided by V, D, J, and C gene expression analysis

    Article • Immunogenetics, December 2019, Springer Science + Business Media

    Dr ir Wilfred van IJcken, Professor Rob J de Boer

  104. G6PD genetic variations in neonatal Hyperbilirubinemia in Indonesian Deutromalay population

    Article • BMC Pediatrics, December 2019, Springer Science + Business Media

    Dr ir Wilfred van IJcken

  105. Gliotoxin, identified from a screen of fungal metabolites, disrupts 7SK snRNP, releases P-TEFb and reverses HIV-1 latency

    Article • November 2019, Cold Spring Harbor Laboratory Press

    Dr ir Wilfred van IJcken

  106. Hemolysis in the Spleen Drives Erythrocyte Turnover

    Article • Blood, November 2019, American Society of Hematology

    Dr ir Wilfred van IJcken

  107. Distinct IL‐1α‐responsive enhancers promote acute and coordinated changes in chromatin topology in a hierarchical manner

    Article • The EMBO Journal, November 2019, EMBO

    Dr ir Wilfred van IJcken

  108. Pathogen-induced activation of disease-suppressive functions in the endophytic root microbiome

    Article • Science, October 2019, American Association for the Advancement of Science

    Dr ir Wilfred van IJcken

  109. Loss of UGP2 in brain leads to a severe epileptic encephalopathy, emphasizing that bi-allelic isoform specific start-loss mutations of essential genes can cause genetic diseases

    Article • October 2019, Cold Spring Harbor Laboratory Press

    Dr ir Wilfred van IJcken

  110. Late-onset phenotype associated with a homozygous GJC2 missense mutation in a Turkish family

    Article • Parkinsonism & Related Disorders, September 2019, Elsevier

    Dr ir Wilfred van IJcken

  111. The presence of CLL-associated stereotypic B cell receptors in the normal BCR repertoire from healthy individuals increases with age

    Article • Immunity & Ageing, August 2019, Springer Science + Business Media

    Dr ir Wilfred van IJcken

  112. A functional variant in the miR‐142 promoter modulating its expression and conferring risk of Alzheimer disease

    Article • Human Mutation, August 2019, Wiley

    Dr ir Wilfred van IJcken

  113. PDGFRB SIGNALING IS REQUIRED TO GENERATE AORTIC HAEMATOPOIETIC CELLS IN VIVO

    Article • Experimental Hematology, August 2019, Elsevier

    Dr ir Wilfred van IJcken

  114. Publisher Correction: Mediator complex interaction partners organize the transcriptional network that defines neural stem cells

    Article • Nature Communications, July 2019, Springer Science + Business Media

    Dr ir Wilfred van IJcken

  115. Lewy pathology in Parkinson’s disease consists of crowded organelles and lipid membranes

    Article • Nature Neuroscience, June 2019, Springer Science + Business Media

    Dr ir Wilfred van IJcken

  116. Mediator complex interaction partners organize the transcriptional network that defines neural stem cells

    Article • Nature Communications, June 2019, Springer Science + Business Media

    Dr ir Wilfred van IJcken

  117. Engram-specific transcriptome profiling of contextual memory consolidation

    Article • Nature Communications, May 2019, Springer Science + Business Media

    Dr ir Wilfred van IJcken

  118. Redundant and specific roles of cohesin STAG subunits in chromatin looping and transcription control

    Article • May 2019, Cold Spring Harbor Laboratory Press

    Dr ir Wilfred van IJcken

  119. Models for infantile hypertrophic pyloric stenosis development in patients with esophageal atresia

    Article • May 2019, Cold Spring Harbor Laboratory Press

    Dr ir Wilfred van IJcken

  120. Modeling the Pathological Long-Range Regulatory Effects of Human Structural Variation with Patient-Specific hiPSCs

    Article • Cell Stem Cell, May 2019, Elsevier

    Dr ir Wilfred van IJcken

  121. The mouse KLF1 Nan variant impairs nuclear condensation and erythroid maturation

    Article • PLoS ONE, March 2019, PLOS

    Dr ir Wilfred van IJcken

  122. Distinct Functions for Mammalian CLASP1 and -2 During Neurite and Axon Elongation

    Article • Frontiers in Cellular Neuroscience, January 2019, Frontiers

    Dr ir Wilfred van IJcken

  123. MAU2 and NIPBL variants in Cornelia de Lange syndrome reveal MAU2-independent loading of cohesin and uncover a protective mechanism against early truncating mutations in NIPBL

    Article • December 2018, Cold Spring Harbor Laboratory Press

    Dr ir Wilfred van IJcken

  124. Epigenome analysis links gene regulatory elements in group 2 innate lymphocytes to asthma susceptibility

    Article • Journal of Allergy and Clinical Immunology, December 2018, Elsevier

    Dr ir Wilfred van IJcken

  125. The mouse Klf1 Nan variant impairs nuclear condensation and erythroid maturation

    Article • November 2018, Cold Spring Harbor Laboratory Press

    Dr ir Wilfred van IJcken

  126. PTRHD1 Loss-of-function mutation in an african family with juvenile-onset Parkinsonism and intellectual disability

    Article • Movement Disorders, November 2018, Wiley

    Dr ir Wilfred van IJcken

  127. Whole-Genome Linkage Scan Combined With Exome Sequencing Identifies Novel Candidate Genes for Carotid Intima-Media Thickness

    Article • Frontiers in Genetics, October 2018, Frontiers

    Dr ir Wilfred van IJcken

  128. Progression of ductal carcinoma in situ to invasive breast cancer: comparative genomic sequencing

    Article • Virchows Archiv, October 2018, Springer Science + Business Media

    Dr ir Wilfred van IJcken

  129. Mitotic progression, arrest, exit or death relies on centromere structural integrity, rather than de novo transcription

    Article • eLife, August 2018, eLife

    Dr ir Wilfred van IJcken

  130. LRP10 genetic variants in familial Parkinson's disease and dementia with Lewy bodies: a genome-wide linkage and sequencing study

    Article • The Lancet Neurology, July 2018, Elsevier

    Professor Piero Parchi, Alessio Di Fonzo, Prof. Cristoforo Comi, Dr ir Wilfred van IJcken

  131. Colony-Stimulating Factor 1 Receptor (CSF1R) Regulates Microglia Density and Distribution, but Not Microglia Differentiation In Vivo

    Article • Cell Reports, July 2018, Elsevier

    Dr ir Wilfred van IJcken

  132. Identification of Variants in RET and IHH Pathway Members in a Large Family With History of Hirschsprung Disease

    Article • Gastroenterology, July 2018, Elsevier

    Dr ir Wilfred van IJcken

  133. Large-Scale Expansion of Human iPSC-Derived Skeletal Muscle Cells for Disease Modeling and Cell-Based Therapeutic Strategies

    Article • Stem Cell Reports, June 2018, Elsevier

    Dr ir Wilfred van IJcken

  134. Employed family-based genetic discovery combining linkage analysis and exome sequencing to identify RCL1 as a novel candidate gene for depression, with independent replication in a population-based cohort

    Article • Molecular Psychiatry, May 2018, Springer Science + Business Media

    Dr ir Wilfred van IJcken

  135. Mitotic progression, arrest, exit or death is determined by centromere integrity and independent of de novo transcription

    Article • March 2018, Cold Spring Harbor Laboratory Press

    Dr ir Wilfred van IJcken

  136. ACO2 homozygous missense mutation associated with complicated hereditary spastic paraplegia

    Article • Neurology Genetics, March 2018, Wolters Kluwer Health

    Dr ir Wilfred van IJcken

  137. Analysis of Mouse Brain Transcriptome After Experimental Duvenhage Virus Infection Shows Activation of Innate Immune Response and Pyroptotic Cell Death Pathway

    Article • Frontiers in Microbiology, March 2018, Frontiers

    Dr ir Wilfred van IJcken

  138. Nimbus: a design-driven analyses suite for amplicon-based NGS data

    Article • Bioinformatics, March 2018, Oxford University Press (OUP)

    Dr ir Wilfred van IJcken

  139. SNPitty

    Article • Journal of Molecular Diagnostics, March 2018, Elsevier

    Dr ir Wilfred van IJcken

  140. Investigation of the spatial structure and interactions of the genome at sub-kilobase-pair resolution using T2C

    Article • Nature Protocols, February 2018, Springer Science + Business Media

    Dr ir Wilfred van IJcken

  141. Sensitive detection of mitochondrial DNA variants for analysis of mitochondrial DNA-enriched extracts from frozen tumor tissue

    Article • Scientific Reports, February 2018, Springer Science + Business Media

    Dr ir Wilfred van IJcken

  142. Allele-specific long-distance regulation dictates IL-32 isoform switching and mediates susceptibility to HIV-1

    Article • Science Advances, February 2018, American Association for the Advancement of Science

    Dr ir Wilfred van IJcken

  143. Variants in members of the cadherin–catenin complex, CDH1 and CTNND1, cause blepharocheilodontic syndrome

    Article • European Journal of Human Genetics, January 2018, Springer Science + Business Media

    Dr ir Wilfred van IJcken

  144. UGT1A1 Genetic Variations and a Haplotype Associated with Neonatal Hyperbilirubinemia

    Article • BioMed Research International, January 2018, Hindawi Publishing Corporation

    Dr ir Wilfred van IJcken, Yunia Sribudiani

  145. Regulation of the cohesin-loading factor NIPBL: Role of the lncRNA NIPBL-AS1 and identification of a distal enhancer element

    Article • PLoS Genetics, December 2017, PLOS

    Dr ir Wilfred van IJcken

  146. Genome-wide DNA methylation profiling using the methylation-dependent restriction enzyme LpnPI

    Article • Genome Research, December 2017, Cold Spring Harbor Laboratory Press

    Dr ir Wilfred van IJcken

  147. Group 2 Innate Lymphoid Cells Exhibit a Dynamic Phenotype in Allergic Airway Inflammation

    Article • Frontiers in Immunology, December 2017, Frontiers

    Dr ir Wilfred van IJcken

  148. Germline variant in MSX1 identified in a Dutch family with clustering of Barrett’s esophagus and esophageal adenocarcinoma

    Article • Familial Cancer, November 2017, Springer Science + Business Media

    Dr ir Wilfred van IJcken

  149. Thyroid State Regulates Gene Expression in Human Whole Blood

    Article • The Journal of Clinical Endocrinology & Metabolism, October 2017, Endocrine Society

    Dr ir Wilfred van IJcken

  150. Exome-Wide Meta-Analysis Identifies Rare 3′-UTR Variant in ERCC1/CD3EAP Associated with Symptoms of Sleep Apnea

    Article • Frontiers in Genetics, October 2017, Frontiers

    Dr ir Wilfred van IJcken

  151. Immune Repertoire after Immunization As Seen by Next-Generation Sequencing and Proteomics

    Article • Frontiers in Immunology, October 2017, Frontiers

    Dr ir Wilfred van IJcken

  152. Transcriptomic Analyses Reveal Differential Gene Expression of Immune and Cell Death Pathways in the Brains of Mice Infected with West Nile Virus and Chikungunya Virus

    Article • Frontiers in Microbiology, August 2017, Frontiers

    Dr ir Wilfred van IJcken

  153. DOC1-Dependent Recruitment of NURD Reveals Antagonism with SWI/SNF during Epithelial-Mesenchymal Transition in Oral Cancer Cells

    Article • Cell Reports, July 2017, Elsevier

    Dr ir Wilfred van IJcken

  154. Loss-of-Function Variants in MYLK Cause Recessive Megacystis Microcolon Intestinal Hypoperistalsis Syndrome

    Article • The American Journal of Human Genetics, July 2017, Elsevier

    Dr ir Wilfred van IJcken

  155. The influence of SNP-based chromosomal microarray and NIPT on the diagnostic yield in 10,000 fetuses with and without fetal ultrasound anomalies

    Article • Human Mutation, May 2017, Wiley

    Dr ir Wilfred van IJcken

  156. Cell lines generated from a chronic lymphocytic leukemia mouse model exhibit constitutive Btk and Akt signaling

    Article • Oncotarget, May 2017, Impact Journals, LLC

    Dr ir Wilfred van IJcken

  157. Lewy pathology in Parkinson’s disease consists of a crowded organellar, membranous medley

    Article • May 2017, Cold Spring Harbor Laboratory Press

    Dr ir Wilfred van IJcken

  158. PRC2 Facilitates the Regulatory Topology Required for Poised Enhancer Function during Pluripotent Stem Cell Differentiation

    Article • Cell Stem Cell, May 2017, Elsevier

    Dr ir Wilfred van IJcken

  159. Fungal volatile compounds induce production of the secondary metabolite Sodorifen in Serratia plymuthica PRI-2C

    Article • Scientific Reports, April 2017, Springer Science + Business Media

    Dr ir Wilfred van IJcken

  160. An interaction network of mental disorder proteins in neural stem cells

    Article • Translational Psychiatry, April 2017, Springer Science + Business Media

    Dr ir Wilfred van IJcken

  161. Nonsynonymous Variation in NKPD1 Increases Depressive Symptoms in European Populations

    Article • Biological Psychiatry, April 2017, Elsevier

    Dr ir Wilfred van IJcken

  162. A rare missense variant in RCL1 segregates with depression in extended families

    Article • Molecular Psychiatry, March 2017, Springer Science + Business Media

    Dr ir Wilfred van IJcken

  163. Loss of LMOD1 impairs smooth muscle cytocontractility and causes megacystis microcolon intestinal hypoperistalsis syndrome in humans and mice

    Article • Proceedings of the National Academy of Sciences, March 2017, Proceedings of the National Academy of Sciences

    Dr ir Wilfred van IJcken

  164. Whole exome sequencing coupled with unbiased functional analysis reveals new Hirschsprung disease genes

    Article • March 2017, Springer Science + Business Media

    Dr ir Wilfred van IJcken

  165. Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging

    Article • Cell, March 2017, Elsevier

    Dr ir Wilfred van IJcken

  166. Exploiting native forces to capture chromosome conformation in mammalian cell nuclei

    Article • Molecular Systems Biology, December 2016, EMBO

    Dr ir Wilfred van IJcken

  167. The detailed 3D multi-loop aggregate/rosette chromatin architecture and functional dynamic organization of the human and mouse genomes

    Article • Epigenetics & Chromatin, December 2016, Springer Science + Business Media

    Dr ir Wilfred van IJcken

  168. Unbiased Interrogation of 3D Genome Topology Using Chromosome Conformation Capture Coupled to High-Throughput Sequencing (4C-Seq)

    Article • November 2016, Springer Science + Business Media

    Dr ir Wilfred van IJcken

  169. Transcriptome assists prognosis of disease severity in respiratory syncytial virus infected infants

    Article • Scientific Reports, November 2016, Springer Science + Business Media

    Dr ir Wilfred van IJcken

  170. Zeb2 Regulates Cell Fate at the Exit from Epiblast State in Mouse Embryonic Stem Cells

    Article • Stem Cells, November 2016, Wiley

    Dr ir Wilfred van IJcken

  171. GATA1-Deficient Dendritic Cells Display Impaired CCL21-Dependent Migration toward Lymph Nodes Due to Reduced Levels of Polysialic Acid

    Article • The Journal of Immunology, November 2016, The American Association of Immunologists

    Dr ir Wilfred van IJcken

  172. Comparison of Mycoplasma pneumoniae Genome Sequences from Strains Isolated from Symptomatic and Asymptomatic Patients

    Article • Frontiers in Microbiology, October 2016, Frontiers

    Dr ir Wilfred van IJcken

  173. Decreased IL7Rα and TdT expression underlie the skewed immunoglobulin repertoire of human B-cell precursors from fetal origin

    Article • Scientific Reports, September 2016, Springer Science + Business Media

    Dr ir Wilfred van IJcken

  174. Binding of nuclear factor κB to noncanonical consensus sites reveals its multimodal role during the early inflammatory response

    Article • Genome Research, September 2016, Cold Spring Harbor Laboratory Press

    Dr ir Wilfred van IJcken

  175. Human age estimation from blood using mRNA, DNA methylation, DNA rearrangement, and telomere length

    Article • Forensic Science International Genetics, September 2016, Elsevier

    Dr ir Wilfred van IJcken

  176. Overexpression of LMO2 causes aberrant human T-Cell development in vivo by three potentially distinct cellular mechanisms

    Article • Experimental Hematology, September 2016, Elsevier

    Dr ir Wilfred van IJcken

  177. Genomes of Ellobius species provide insight into the evolutionary dynamics of mammalian sex chromosomes

    Article • Genome Research, August 2016, Cold Spring Harbor Laboratory Press

    Dr ir Wilfred van IJcken

  178. Exome-sequencing in a large population-based study reveals a rare Asn396Ser variant in the LIPG gene associated with depressive symptoms

    Article • Molecular Psychiatry, July 2016, Springer Science + Business Media

    Dr ir Wilfred van IJcken

  179. Human USP18 deficiency underlies type 1 interferonopathy leading to severe pseudo-TORCH syndrome

    Article • The Journal of Experimental Medicine, June 2016, Rockefeller University Press

    Dr ir Wilfred van IJcken

  180. Genetic variants in RBFOX3 are associated with sleep latency

    Article • European Journal of Human Genetics, May 2016, Springer Science + Business Media

    Dr ir Wilfred van IJcken

  181. Inefficient DNA Repair Is an Aging-Related Modifier of Parkinson’s Disease

    Article • Cell Reports, May 2016, Elsevier

    Dr ir Wilfred van IJcken, Dr. Sandra Moreno

  182. Paroxysmal exercise-induced dystonia within the phenotypic spectrum ofECHS1deficiency

    Article • Movement Disorders, April 2016, Wiley

    Dr ir Wilfred van IJcken

  183. Effects of Freeze–Thawing and Intravenous Infusion on Mesenchymal Stromal Cell Gene Expression

    Article • Stem Cells and Development, April 2016, Mary Ann Liebert Inc

    Dr ir Wilfred van IJcken

  184. BMP and Hedgehog Regulate Distinct AGM Hematopoietic Stem Cells Ex Vivo

    Article • Stem Cell Reports, March 2016, Elsevier

    Dr ir Wilfred van IJcken

  185. Complex MAX Rearrangement in a Family With Malignant Pheochromocytoma, Renal Oncocytoma, and Erythrocytosis

    Article • The Journal of Clinical Endocrinology & Metabolism, February 2016, Endocrine Society

    Dr ir Wilfred van IJcken

  186. Biallelic Truncating Mutations in ALPK3 Cause Severe Pediatric Cardiomyopathy

    Article • Journal of the American College of Cardiology, February 2016, Elsevier

    Dr ir Wilfred van IJcken

  187. ACTG2variants impair actin polymerization in sporadic Megacystis Microcolon Intestinal Hypoperistalsis Syndrome

    Article • Human Molecular Genetics, December 2015, Oxford University Press (OUP)

    Dr ir Wilfred van IJcken

  188. Control of developmentally primed erythroid genes by combinatorial co-repressor actions

    Article • Nature Communications, November 2015, Springer Science + Business Media

    Dr ir Wilfred van IJcken

  189. miR-634 restores drug sensitivity in resistant ovarian cancer cells by targeting the Ras-MAPK pathway

    Article • Molecular Cancer, November 2015, Springer Science + Business Media

    Dr Erik A.C. Wiemer, Dr ir Wilfred van IJcken

  190. Erratum: Corrigendum: BMP signalling differentially regulates distinct haematopoietic stem cell types

    Article • Nature Communications, October 2015, Springer Science + Business Media

    Dr ir Wilfred van IJcken

  191. Nuclear positioning rather than contraction controls ordered rearrangements of immunoglobulin loci

    Article • Nucleic Acids Research, September 2015, Oxford University Press (OUP)

    Dr ir Wilfred van IJcken

  192. Next-generation sequencing-based genome diagnostics across clinical genetics centers: implementation choices and their effects

    Article • European Journal of Human Genetics, September 2015, Nature

    Mr Lennart Johansson, Dr ir Wilfred van IJcken

  193. The Isl1/Ldb1 Complex Orchestrates Genome-wide Chromatin Organization to Instruct Differentiation of Multipotent Cardiac Progenitors

    Article • Cell Stem Cell, September 2015, Elsevier

    Dr ir Wilfred van IJcken

  194. BMP signalling differentially regulates distinct haematopoietic stem cell types

    Article • Nature Communications, August 2015, Springer Science + Business Media

    Dr ir Wilfred van IJcken

  195. The core spliceosome as target and effector of non-canonical ATM signalling

    Article • Nature, June 2015, Springer Science + Business Media

    Dr ir Wilfred van IJcken

  196. DC immunotherapy in HIV-1 infection induces a major blood transcriptome shift

    Article • Vaccine, June 2015, Elsevier

    Dr ir Wilfred van IJcken

  197. Proteins that bind regulatory regions identified by histone modification chromatin immunoprecipitations and mass spectrometry

    Article • Nature Communications, May 2015, Springer Science + Business Media

    Dr ir Wilfred van IJcken

  198. Genetics of skin color variation in Europeans: genome-wide association studies with functional follow-up

    Article • Human Genetics, May 2015, Springer Science + Business Media

    Dr Massimo Mangino, Dr ir Wilfred van IJcken

  199. Allogeneic Mature Human Dendritic Cells Generate Superior Alloreactive Regulatory T Cells in the Presence of IL-15

    Article • The Journal of Immunology, April 2015, The American Association of Immunologists

    Dr ir Wilfred van IJcken

  200. A New CRB1 Rat Mutation Links Müller Glial Cells to Retinal Telangiectasia

    Article • Journal of Neuroscience, April 2015, Society for Neuroscience

    Dr ir Wilfred van IJcken

  201. Incomplete meiotic sex chromosome inactivation in the domestic dog

    Article • BMC Genomics, April 2015, Springer Science + Business Media

    Dr ir Wilfred van IJcken

  202. PLD3 variants in population studies

    Article • Nature, April 2015, Springer Science + Business Media

    Dr ir Wilfred van IJcken

  203. Correction: Hypoxia Inducible Factor 3α Plays a Critical Role in Alveolarization and Distal Epithelial Cell Differentiation during Mouse Lung Development

    Article • PLoS ONE, March 2015, PLOS

    Dr ir Wilfred van IJcken

  204. Time since Onset of Disease and Individual Clinical Markers Associate with Transcriptional Changes in Uncomplicated Dengue

    Article • PLoS Neglected Tropical Diseases, March 2015, PLOS

    Dr ir Wilfred van IJcken

  205. Targeted Next Generation Sequencing reveals previously unidentified TSC1 and TSC2 mutations

    Article • BMC Medical Genetics, February 2015, Springer Science + Business Media

    Dr ir Wilfred van IJcken

  206. Next-generation sequencing-based genome diagnostics across clinical genetics centers: implementation choices and their effects

    Article • European Journal of Human Genetics, January 2015, Nature

    Mr Lennart Johansson, Dr ir Wilfred van IJcken

  207. Global quantitative proteomics reveals novel factors in the ecdysone signaling pathway inDrosophila melanogaster

    Article • PROTEOMICS, January 2015, Wiley

    Dr ir Wilfred van IJcken

  208. Deciphering the RNA landscape by RNAome sequencing

    Article • RNA Biology, January 2015, Taylor & Francis

    Dr ir Wilfred van IJcken

  209. Endogenous WNT Signals Mediate BMP-Induced and Spontaneous Differentiation of Epiblast Stem Cells and Human Embryonic Stem Cells

    Article • Stem Cell Reports, January 2015, Elsevier

    Dr ir Wilfred van IJcken

  210. Whole-transcriptome analysis of endothelial to hematopoietic stem cell transition reveals a requirement for Gpr56 in HSC generation

    Article • The Journal of Experimental Medicine, December 2014, Rockefeller University Press

    Dr ir Wilfred van IJcken

  211. Sp1/Sp3 transcription factors regulate hallmarks of megakaryocyte maturation and platelet formation and function

    Article • Blood, December 2014, American Society of Hematology

    Dr ir Wilfred van IJcken

  212. Gene reprogramming in exercise-induced cardiac hypertrophy in swine: A transcriptional genomics approach

    Article • Journal of Molecular and Cellular Cardiology, December 2014, Elsevier

    Dr ir Wilfred van IJcken

  213. Regulated genes in psoriatic skin during treatment with fumaric acid esters

    Article • British Journal of Dermatology, September 2014, Oxford University Press (OUP)

    Dr ir Wilfred van IJcken

  214. The dystrophin gene and cognitive function in the general population

    Article • European Journal of Human Genetics, September 2014, Springer Science + Business Media

    Dr ir Wilfred van IJcken

  215. Identification of microRNAs in Human Plasma

    Article • September 2014, Springer Science + Business Media

    Dr ir Wilfred van IJcken

  216. Ovarian Cancer Cell Line Panel (OCCP): Clinical Importance of In Vitro Morphological Subtypes

    Article • PLoS ONE, September 2014, PLOS

    Dr ir Wilfred van IJcken

  217. Analysis of the transcriptome and immune function of monocytes during IFNα-based therapy in chronic HCV revealed induction of TLR7 responsiveness

    Article • Antiviral Research, September 2014, Elsevier

    Dr ir Wilfred van IJcken

  218. SF3B1 and EIF1AX mutations in uveal melanoma: a protective factor, or not?

    Article • Acta Ophthalmologica, August 2014, Wiley

    Dr ir Wilfred van IJcken

  219. Gene Expression Profiling To Predict and Assess the Consequences of Therapy-Induced Virus Eradication in Chronic Hepatitis C Virus Infection

    Article • Journal of Virology, August 2014, ASM Journals

    Dr ir Wilfred van IJcken

  220. MicroRNA response to hypoxic stress in soft tissue sarcoma cells: microRNA mediated regulation of HIF3α

    Article • BMC Cancer, June 2014, Springer Science + Business Media

    Dr Erik A.C. Wiemer, Dr ir Wilfred van IJcken

  221. Clinical significance of immunohistochemistry for detection of BAP1 mutations in uveal melanoma

    Article • Modern Pathology, March 2014, Springer Science + Business Media

    Dr ir Wilfred van IJcken

  222. HBS1L-MYB intergenic variants modulate fetal hemoglobin via long-range MYB enhancers

    Article • Journal of Clinical Investigation, March 2014, American Society for Clinical Investigation

    Dr ir Wilfred van IJcken

  223. Pre-B Cell Receptor Signaling Induces Immunoglobulin κ Locus Accessibility by Functional Redistribution of Enhancer-Mediated Chromatin Interactions

    Article • PLoS Biology, February 2014, PLOS

    Dr ir Wilfred van IJcken

  224. Two independent transcription initiation codes overlap on vertebrate core promoters

    Article • Nature, February 2014, Nature

    Altuna A, Piero Carninci, Dr ir Wilfred van IJcken

  225. A Cohesin-Independent Role for NIPBL at Promoters Provides Insights in CdLS

    Article • PLoS Genetics, February 2014, PLOS

    Dr ir Wilfred van IJcken

  226. MicroRNA expression profiles distinguish liposarcoma subtypes and implicate miR-145 and miR-451 as tumor suppressors

    Article • International Journal of Cancer, January 2014, Wiley

    Dr Erik A.C. Wiemer, Dr ir Wilfred van IJcken

  227. In vivo murine hepatic microRNA and mRNA expression signatures predicting the (non-)genotoxic carcinogenic potential of chemicals

    Article • Archives of Toxicology, January 2014, Springer Science + Business Media

    Dr. ir. Tessa Pronk, Dr ir Wilfred van IJcken

  228. Gene Expression Analysis Reveals Inhibition of Radiation-Induced TGFβ-Signaling by Hyperbaric Oxygen Therapy in Mouse Salivary Glands

    Article • Molecular Medicine, January 2014, Springer Science + Business Media

    Dr ir Wilfred van IJcken

  229. Targeted Chromatin Capture (T2C): a novel high resolution high throughput method to detect genomic interactions and regulatory elements

    Article • Epigenetics & Chromatin, January 2014, Springer Science + Business Media

    Dr ir Wilfred van IJcken

  230. DNA damage responsive microRNAs misexpressed in human cancer modulate therapy sensitivity

    Article • Molecular Oncology, December 2013, Wiley

    Dr Erik A.C. Wiemer, Dr ir Wilfred van IJcken

  231. Cohesin and CTCF differentially affect chromatin architecture and gene expression in human cells

    Article • Proceedings of the National Academy of Sciences, December 2013, Proceedings of the National Academy of Sciences

    Dr ir Wilfred van IJcken

  232. Gene Expression Analysis of Peripheral Cells for Subclassification of Pediatric Inflammatory Bowel Disease in Remission

    Article • PLoS ONE, November 2013, PLOS

    Dr ir Wilfred van IJcken

  233. BACH2: A marker of DNA damage and ageing

    Article • DNA Repair, November 2013, Elsevier

    Dr ir Wilfred van IJcken

  234. Exome sequencing and functional analyses suggest that SIX6 is a gene involved in an altered proliferation–differentiation balance early in life and optic nerve degeneration at old age

    Article • Human Molecular Genetics, October 2013, Oxford University Press (OUP)

    Dr ir Wilfred van IJcken

  235. Developmental and Activity-Dependent miRNA Expression Profiling in Primary Hippocampal Neuron Cultures

    Article • PLoS ONE, October 2013, PLOS

    Dr ir Wilfred van IJcken

  236. Contribution of rare and common variants determine complex diseases—Hirschsprung disease as a model

    Article • Developmental Biology, October 2013, Elsevier

    Dr ir Wilfred van IJcken

  237. Histone Chaperone NAP1 Mediates Sister Chromatid Resolution by Counteracting Protein Phosphatase 2A

    Article • PLoS Genetics, September 2013, PLOS

    Dr ir Wilfred van IJcken

  238. Dynamic regulation of the transcription initiation landscape at single nucleotide resolution during vertebrate embryogenesis

    Article • Genome Research, September 2013, Cold Spring Harbor Laboratory Press

    Altuna A, Piero Carninci, Dr ir Wilfred van IJcken

  239. MiR-17-92 and miR-221/222 cluster members target KIT and ETV1 in human gastrointestinal stromal tumours

    Article • British Journal of Cancer, August 2013, Springer Science + Business Media

    Dr Erik A.C. Wiemer, Dr ir Wilfred van IJcken

  240. Genome-wide, whole mount in situ analysis of transcriptional regulators in zebrafish embryos

    Article • Developmental Biology, August 2013, Elsevier

    Dr ir Wilfred van IJcken

  241. Next generation sequencing of SNPs for non-invasive prenatal diagnosis: challenges and feasibility as illustrated by an application to β-thalassaemia

    Article • European Journal of Human Genetics, April 2013, Springer Science + Business Media

    Dr ir Wilfred van IJcken

  242. Balancing of Histone H3K4 Methylation States by the Kdm5c/SMCX Histone Demethylase Modulates Promoter and Enhancer Function

    Article • Cell Reports, April 2013, Elsevier

    Dr ir Wilfred van IJcken

  243. In vivo live imaging of RNA polymerase II transcription factories in primary cells

    Article • Genes & Development, April 2013, Cold Spring Harbor Laboratory Press

    Dr ir Wilfred van IJcken

  244. Canonical Wnt Signaling Induces a Primitive Endoderm Metastable State in Mouse Embryonic Stem Cells

    Article • Stem Cells, March 2013, Wiley

    Dr ir Wilfred van IJcken

  245. Small Hydrophobic Protein of Human Metapneumovirus Does Not Affect Virus Replication and Host Gene Expression In Vitro

    Article • PLoS ONE, March 2013, PLOS

    Dr ir Wilfred van IJcken

  246. Early divergence of Th1 and Th2 transcriptomes involves a small core response and sets of transiently expressed genes

    Article • European Journal of Immunology, March 2013, Wiley

    Professor Rob J de Boer, Dr ir Wilfred van IJcken

  247. Hypoxia Inducible Factor 3α Plays a Critical Role in Alveolarization and Distal Epithelial Cell Differentiation during Mouse Lung Development

    Article • PLoS ONE, February 2013, PLOS

    Dr ir Wilfred van IJcken

  248. Multiplexed chromosome conformation capture sequencing for rapid genome-scale high-resolution detection of long-range chromatin interactions

    Article • Nature Protocols, February 2013, Springer Science + Business Media

    Dr ir Wilfred van IJcken

  249. Genome-wide analysis shows that Ldb1 controls essential hematopoietic genes/pathways in mouse early development and reveals novel players in hematopoiesis

    Article • Blood, February 2013, American Society of Hematology

    Dr ir Wilfred van IJcken

  250. MicroRNA-133 Controls Brown Adipose Determination in Skeletal Muscle Satellite Cells by Targeting Prdm16

    Article • Cell Metabolism, February 2013, Elsevier

    Dr ir Wilfred van IJcken

  251. Genome Instability in Lactobacillus rhamnosus GG

    Article • Applied and Environmental Microbiology, January 2013, ASM Journals

    Dr ir Wilfred van IJcken, Prof. Dr. Koen Venema

  252. Directed Migration of Cortical Interneurons Depends on the Cell-Autonomous Action of Sip1

    Article • Neuron, January 2013, Elsevier

    Dr ir Wilfred van IJcken

  253. MicroRNA-Mediated Down-Regulation of M-CSF Receptor Contributes to Maturation of Mouse Monocyte-Derived Dendritic Cells

    Article • Frontiers in Immunology, January 2013, Frontiers

    Dr ir Wilfred van IJcken

  254. Hydroxyurea responsiveness in  -thalassemic patients is determined by the stress response adaptation of erythroid progenitors and their differentiation propensity

    Article • Haematologica, October 2012, Ferrata Storti Foundation (Haematologica)

    Dr ir Wilfred van IJcken

  255. miR-141 regulates KEAP1 and modulates cisplatin sensitivity in ovarian cancer cells

    Article • Oncogene, October 2012, Springer Science + Business Media

    Dr Erik A.C. Wiemer, Dr ir Wilfred van IJcken

  256. KLF10gene expression is associated with high fetal hemoglobin levels and with response to hydroxyurea treatment in β-hemoglobinopathy patients

    Article • Pharmacogenomics, October 2012, Future Medicine

    Dr ir Wilfred van IJcken

  257. The Microtubule Plus-End Tracking Protein CLASP2 Is Required for Hematopoiesis and Hematopoietic Stem Cell Maintenance

    Article • Cell Reports, October 2012, Elsevier

    Dr ir Wilfred van IJcken

  258. Snail Regulates MyoD Binding-Site Occupancy to Direct Enhancer Switching and Differentiation-Specific Transcription in Myogenesis

    Article • Molecular Cell, August 2012, Elsevier

    Dr ir Wilfred van IJcken

  259. A Novel Complex, RUNX1-MYEF2, Represses Hematopoietic Genes in Erythroid Cells

    Article • Molecular and Cellular Biology, July 2012, ASM Journals

    Dr ir Wilfred van IJcken

  260. Metabolic Enzyme IMPDH Is Also a Transcription Factor Regulated by Cellular State

    Article • Molecular Cell, July 2012, Elsevier

    Dr ir Wilfred van IJcken

  261. The male germ cell gene regulator CTCFL is functionally different from CTCF and binds CTCF-like consensus sites in a nucleosome composition-dependent manner

    Article • Epigenetics & Chromatin, June 2012, Springer Science + Business Media

    Dr ir Wilfred van IJcken

  262. Transcriptional Dominance of Pax7 in Adult Myogenesis Is Due to High-Affinity Recognition of Homeodomain Motifs

    Article • Developmental Cell, June 2012, Elsevier

    Dr ir Wilfred van IJcken

  263. RNF12 initiates X-chromosome inactivation by targeting REX1 for degradation

    Article • Nature, April 2012, Springer Science + Business Media

    Dr ir Wilfred van IJcken

  264. A new function of ROD1 in nonsense-mediated mRNA decay

    Article • FEBS Letters, March 2012, Wiley

    Dr ir Wilfred van IJcken

  265. Hypoxia-Inducible Factor 2α Plays a Critical Role in the Formation of Alveoli and Surfactant

    Article • American Journal of Respiratory Cell and Molecular Biology, February 2012, American Thoracic Society

    Dr ir Wilfred van IJcken

  266. Progesterone Inhibits Epithelial-to-Mesenchymal Transition in Endometrial Cancer

    Article • PLoS ONE, January 2012, PLOS

    Dr ir Wilfred van IJcken

  267. Genome-wide DNA methylation profiling of non-small cell lung carcinomas

    Article • Epigenetics & Chromatin, January 2012, Springer Science + Business Media

    Dr ir Wilfred van IJcken

  268. Dynamic long-range chromatin interactions controlMybproto-oncogene transcription during erythroid development

    Article • The EMBO Journal, December 2011, Wiley

    Dr ir Wilfred van IJcken

  269. Remodelers Organize Cellular Chromatin by Counteracting Intrinsic Histone-DNA Sequence Preferences in a Class-Specific Manner

    Article • Molecular and Cellular Biology, November 2011, ASM Journals

    Dr ir Wilfred van IJcken

  270. NARWHAL, a primary analysis pipeline for NGS data

    Article • Bioinformatics, November 2011, Oxford University Press (OUP)

    Dr ir Wilfred van IJcken

  271. Left ventricular remodeling in swine after myocardial infarction: a transcriptional genomics approach

    Article • Basic Research in Cardiology, November 2011, Springer Science + Business Media

    Dr ir Wilfred van IJcken

  272. The DNA-Binding Protein CTCF Limits Proximal Vκ Recombination and Restricts κ Enhancer Interactions to the Immunoglobulin κ Light Chain Locus

    Article • Immunity, October 2011, Elsevier

    Dr ir Wilfred van IJcken

  273. Modulation of Androgen Receptor Signaling in Hormonal Therapy-Resistant Prostate Cancer Cell Lines

    Article • PLoS ONE, August 2011, PLOS

    Dr ir Wilfred van IJcken

  274. Absence of Common Somatic Alterations in Genes on 1p and 19q in Oligodendrogliomas

    Article • PLoS ONE, July 2011, PLOS

    Dr ir Wilfred van IJcken

  275. Chronic IFN-  production in mice induces anemia by reducing erythrocyte life span and inhibiting erythropoiesis through an IRF-1/PU.1 axis

    Article • Blood, July 2011, American Society of Hematology

    Dr ir Wilfred van IJcken

  276. Effective Treatment of Psoriasis with Narrow-Band UVB Phototherapy Is Linked to Suppression of the IFN and Th17 Pathways

    Article • Journal of Investigative Dermatology, July 2011, Elsevier

    Dr ir Wilfred van IJcken

  277. The inactive X chromosome adopts a unique three-dimensional conformation that is dependent on Xist RNA

    Article • Genes & Development, June 2011, Cold Spring Harbor Laboratory Press

    Professor Wouter de Laat, Dr ir Wilfred van IJcken

  278. Gene expression profiling assigns CHEK2 1100delC breast cancers to the luminal intrinsic subtypes

    Article • Breast Cancer Research and Treatment, May 2011, Springer Science + Business Media

    Dr ir Wilfred van IJcken

  279. Discovery of new microRNAs by small RNAome deep sequencing in childhood acute lymphoblastic leukemia

    Article • Leukemia, May 2011, Springer Science + Business Media

    Dr ir Wilfred van IJcken

  280. The DNA binding factor Hmg20b is a repressor of erythroid differentiation

    Article • Haematologica, May 2011, Ferrata Storti Foundation (Haematologica)

    Dr ir Wilfred van IJcken

  281. Sox2 cooperates with Chd7 to regulate genes that are mutated in human syndromes

    Article • Nature Genetics, May 2011, Springer Science + Business Media

    Dr ir Wilfred van IJcken

  282. Mobilization of hepatic mesenchymal stem cells from human liver grafts

    Article • Liver Transplantation, April 2011, Wiley

    Dr ir Wilfred van IJcken, Dr. Fatima Aerts Kaya

  283. Distinct Severe Acute Respiratory Syndrome Coronavirus-Induced Acute Lung Injury Pathways in Two Different Nonhuman Primate Species

    Article • Journal of Virology, February 2011, ASM Journals

    Professor (Associate) Bart L. Haagmans, Dr ir Wilfred van IJcken

  284. A systems approach to analyze transcription factors in mammalian cells

    Article • Methods, February 2011, Elsevier

    Dr ir Wilfred van IJcken

  285. Inflammatory conditions affect gene expression and function of human adipose tissue-derived mesenchymal stem cells

    Article • Clinical & Experimental Immunology, September 2010, Wiley

    Dr ir Wilfred van IJcken

  286. Transcriptional profiling of fibroblasts from patients with mutations in MCT8 and comparative analysis with the human brain transcriptome

    Article • Human Molecular Genetics, August 2010, Oxford University Press (OUP)

    Dr ir Wilfred van IJcken

  287. Haploinsufficiency for the erythroid transcription factor KLF1 causes hereditary persistence of fetal hemoglobin

    Article • Nature Genetics, August 2010, Springer Science + Business Media

    Dr ir Wilfred van IJcken

  288. Unacylated Ghrelin Rapidly Modulates Lipogenic and Insulin Signaling Pathway Gene Expression in Metabolically Active Tissues of GHSR Deleted Mice

    Article • PLoS ONE, July 2010, PLOS

    Dr ir Wilfred van IJcken

  289. Pandemic 2009 H1N1 Influenza Virus Causes Diffuse Alveolar Damage in Cynomolgus Macaques

    Article • Veterinary Pathology, July 2010, SAGE Publications

    Dr ir Wilfred van IJcken

  290. FUNCTION OF HUMAN MESENCHYMAL STEM CELLS UNDER INFLAMMATORY CONDITIONS

    Article • Transplantation, July 2010, Wolters Kluwer Health

    Dr ir Wilfred van IJcken

  291. Gene Expression-Based Classification of Non-Small Cell Lung Carcinomas and Survival Prediction

    Article • PLoS ONE, April 2010, PLOS

    Dr ir Wilfred van IJcken

  292. Exacerbated Innate Host Response to SARS-CoV in Aged Non-Human Primates

    Article • PLoS Pathogens, February 2010, PLOS

    Professor (Associate) Bart L. Haagmans, Dr ir Wilfred van IJcken

  293. Short-term dietary restriction and fasting precondition against ischemia reperfusion injury in mice

    Article • Aging Cell, February 2010, Wiley

    Dr ir Wilfred van IJcken

  294. The genome-wide dynamics of the binding of Ldb1 complexes during erythroid differentiation

    Article • Genes & Development, February 2010, Cold Spring Harbor Laboratory Press

    Dr ir Wilfred van IJcken

  295. Cell-specific occupancy of an extended repertoire of CREM and CREB binding loci in male germ cells

    Article • BMC Genomics, January 2010, Springer Science + Business Media

    Dr ir Wilfred van IJcken

  296. The ubiquitin-conjugating enzyme HR6B is required for maintenance of X chromosome silencing in mouse spermatocytes and spermatids

    Article • BMC Genomics, January 2010, Springer Science + Business Media

    Dr ir Wilfred van IJcken

  297. CITED2 and NCOR2 in anti-oestrogen resistance and progression of breast cancer

    Article • British Journal of Cancer, November 2009, Springer Science + Business Media

    Dr ir Wilfred van IJcken

  298. Monitoring of the Immunomodulatory Effect of CP-690,550 by Analysis of the JAK/STAT Pathway in Kidney Transplant Patients

    Article • Transplantation, October 2009, Wolters Kluwer Health

    Dr ir Wilfred van IJcken

  299. The FOXF2 pathway in the human prostate stroma

    Article • The Prostate, October 2009, Wiley

    Dr ir Wilfred van IJcken

  300. Physiological Thyroid Hormone Levels Regulate Numerous Skeletal Muscle Transcripts

    Article • The Journal of Clinical Endocrinology & Metabolism, September 2009, Endocrine Society

    Dr ir Wilfred van IJcken

  301. MicroRNA-mediated gene silencing modulates the UV-induced DNA-damage response

    Article • The EMBO Journal, June 2009, Wiley

    Dr Erik A.C. Wiemer, Dr ir Wilfred van IJcken

  302. Persistent transcription-blocking DNA lesions trigger somatic growth attenuation associated with longevity

    Article • Nature Cell Biology, April 2009, Springer Science + Business Media

    Dr ir Wilfred van IJcken

  303. Gene Expression Profiling in Uveal Melanoma: Two Regions on 3p Related to Prognosis

    Article • Investigative Ophthalmology & Visual Science, October 2008, Association for Research in Vision and Ophthalmology (ARVO)

    Dr ir Wilfred van IJcken

  304. Delayed and Accelerated Aging Share Common Longevity Assurance Mechanisms

    Article • PLoS Genetics, August 2008, PLOS

    Dr ir Wilfred van IJcken

  305. MN1 affects expression of genes involved in hematopoiesis and can enhance as well as inhibit RAR/RXR-induced gene expression

    Article • Carcinogenesis, July 2008, Oxford University Press (OUP)

    Dr ir Wilfred van IJcken

  306. Transcription and Chromatin Organization of a Housekeeping Gene Cluster Containing an Integrated β-Globin Locus Control Region

    Article • PLoS Genetics, March 2008, PLOS

    Professor Wouter de Laat, Dr ir Wilfred van IJcken

  307. Three Genome-wide Association Studies and a Linkage Analysis Identify HERC2 as a Human Iris Color Gene

    Article • The American Journal of Human Genetics, March 2008, Elsevier

    Dr ir Wilfred van IJcken

  308. Three Genome-wide Association Studies and a Linkage Analysis Identify HERC2 as a Human Iris Color Gene

    Article • The American Journal of Human Genetics, February 2008, Elsevier

    Dr ir Wilfred van IJcken

  309. Difference in signalling between various hormone therapies in endometrium, myometrium and upper part of the vagina

    Article • Human Reproduction, December 2007, Oxford University Press (OUP)

    Dr ir Wilfred van IJcken

  310. Genomic and Nongenomic Effects of Estrogen Signaling in Human Endometrial Cells: Involvement of the Growth Factor Receptor Signaling Downstream AKT Pathway

    Article • Reproductive Sciences, October 2007, SAGE Publications

    Dr ir Wilfred van IJcken

  311. Stable RNA markers for identification of blood and saliva stains revealed from whole genome expression analysis of time-wise degraded samples

    Article • International Journal of Legal Medicine, June 2007, Springer Science + Business Media

    Dr ir Wilfred van IJcken

  312. HPV related VIN: Highly proliferative and diminished responsiveness to extracellular signals

    Article • International Journal of Cancer, January 2007, Wiley

    Dr ir Wilfred van IJcken

  313. The hormone replacement therapy drug tibolone acts very similar to medroxyprogesterone acetate in an estrogen-and progesterone-responsive endometrial cancer cell line

    Article • Journal of Molecular Endocrinology, December 2006, Bioscientifica

    Dr ir Wilfred van IJcken

  314. Functional Differentiation of SWI/SNF Remodelers in Transcription and Cell Cycle Control

    Article • Molecular and Cellular Biology, November 2006, ASM Journals

    Dr ir Wilfred van IJcken

  315. Characterization of Spodoptera exigua multicapsid nucleopolyhedrovirus ORF17/18, a homologue of Xestia c-nigrum granulovirus ORF129

    Article • Journal of General Virology, November 2002, Society for General Microbiology

    Dr ir Wilfred van IJcken

  316. Furin Is Involved in Baculovirus Envelope Fusion Protein Activation

    Article • Journal of Virology, January 2002, ASM Journals

    Dr ir Wilfred van IJcken

  317. Identification of a Novel Occlusion Derived Virus-Specific Protein in Spodoptera exigua Multicapsid Nucleopolyhedrovirus

    Article • Virology, June 2001, Elsevier

    Dr ir Wilfred van IJcken

  318. The sequence of the Helicoverpa armigera single nucleocapsid nucleopolyhedrovirus genome

    Article • Journal of General Virology, January 2001, Society for General Microbiology

    Zhihong Hu, Dr ir Wilfred van IJcken

  319. Characteristics of the transactivator gene ie1 of Spodoptera exigua multiple nucleopolyhedrovirus

    Article • Archives of Virology, October 2000, Springer Science + Business Media

    Dr ir Wilfred van IJcken

  320. Isolation of a Spodoptera exigua baculovirus recombinant with a 10·6 kbp genome deletion that retains biological activity

    Article • Journal of General Virology, October 2000, Society for General Microbiology

    Dr ir Wilfred van IJcken

  321. A Novel Baculovirus Envelope Fusion Protein with a Proprotein Convertase Cleavage Site

    Article • Virology, September 2000, Elsevier

    Professor Gary W Blissard, Dr ir Wilfred van IJcken

  322. Identification, sequence analysis and phylogeny of the lef-2 gene of Helicoverpa armigera single-nucleocapsid baculovirus

    Article • Virus Research, December 1999, Elsevier

    Zhihong Hu, Dr ir Wilfred van IJcken

  323. Sequence and organization of the Spodoptera exigua multicapsid nucleopolyhedrovirus genome

    Article • Journal of General Virology, December 1999, Society for General Microbiology

    Dr ir Wilfred van IJcken