All Stories

  1. Targeted sequencing by proximity ligation for comprehensive variant detection and local haplotyping

    Article • Nature Biotechnology, August 2014, Springer Science + Business Media

    Professor Wouter de Laat

  2. Genome-wide analysis of FOXO3 mediated transcription regulation through RNA polymerase II profiling

    Article • Molecular Systems Biology, April 2014, EMBO

    Professor Wouter de Laat

  3. A Single Oncogenic Enhancer Rearrangement Causes Concomitant EVI1 and GATA2 Deregulation in Leukemia

    Article • Cell, April 2014, Elsevier

    Professor Wouter de Laat

  4. A common genetic variant within SCN10A modulates cardiac SCN5A expression

    Article • Journal of Clinical Investigation, March 2014, American Society for Clinical Investigation

    Professor Wouter de Laat

  5. Long-Range Chromatin Contacts in Embryonic Stem Cells Reveal a Role for Pluripotency Factors and Polycomb Proteins in Genome Organization

    Article • Cell Stem Cell, November 2013, Elsevier

    Professor Wouter de Laat

  6. Topology of mammalian developmental enhancers and their regulatory landscapes

    Article • Nature, October 2013, Springer Science + Business Media

    Professor Wouter de Laat

  7. For Genomes to Stay in Shape, Insulators Must Be up to PAR

    Article • Cell, September 2013, Elsevier

    Professor Wouter de Laat

  8. Flexible Long-Range Loops in the VH Gene Region of the Igh Locus Facilitate the Generation of a Diverse Antibody Repertoire

    Article • Immunity, August 2013, Elsevier

    Professor Wouter de Laat

  9. The pluripotent genome in three dimensions is shaped around pluripotency factors

    Article • Nature, July 2013, Springer Science + Business Media

    Professor Wouter de Laat

  10. Allelic exclusion of the immunoglobulin heavy chain locus is independent of its nuclear localization in mature B cells

    Article • Nucleic Acids Research, June 2013, Oxford University Press (OUP)

    Professor Wouter de Laat

  11. DNA methylation dynamics during intestinal stem cell differentiation reveals enhancers driving gene expression in the villus

    Article • May 2013, Springer Science + Business Media

    Professor Wouter de Laat

  12. CTCF: the protein, the binding partners, the binding sites and their chromatin loops

    Article • Philosophical Transactions of the Royal Society B Biological Sciences, May 2013, Royal Society Publishing

    Professor Wouter de Laat

  13. Identical cells with different 3D genomes; cause and consequences?

    Article • Current Opinion in Genetics & Development, April 2013, Elsevier

    Professor Wouter de Laat

  14. eRNAs Are Required for p53-Dependent Enhancer Activity and Gene Transcription

    Article • Molecular Cell, February 2013, Elsevier

    Professor Wouter de Laat

  15. 3C-based technologies to study the shape of the genome

    Article • Methods, November 2012, Elsevier

    Professor Wouter de Laat

  16. Determining long-range chromatin interactions for selected genomic sites using 4C-seq technology: From fixation to computation

    Article • Methods, November 2012, Elsevier

    Professor Wouter de Laat

  17. Robust 4C-seq data analysis to screen for regulatory DNA interactions

    Article • Nature Methods, September 2012, Springer Science + Business Media

    Professor Wouter de Laat

  18. Chromatin loops, gene positioning, and gene expression

    Article • Frontiers in Genetics, January 2012, Frontiers

    Professor Wouter de Laat

  19. 4C Technology: Protocols and Data Analysis

    Article • January 2012, Elsevier

    Professor Wouter de Laat

  20. A decade of 3C technologies: insights into nuclear organization

    Article • Genes & Development, January 2012, Cold Spring Harbor Laboratory Press

    Professor Wouter de Laat

  21. A Regulatory Archipelago Controls Hox Genes Transcription in Digits

    Article • Cell, November 2011, Elsevier

    Professor Wouter de Laat

  22. The Dynamic Architecture of Hox Gene Clusters

    Article • Science, October 2011, American Association for the Advancement of Science

    Professor Wouter de Laat

  23. The complex transcription regulatory landscape of our genome: control in three dimensions

    Article • The EMBO Journal, September 2011, Springer Science + Business Media

    Professor Wouter de Laat

  24. Variegated gene expression caused by cell-specific long-range DNA interactions

    Article • Nature Cell Biology, June 2011, Springer Science + Business Media

    Professor Wouter de Laat

  25. The inactive X chromosome adopts a unique three-dimensional conformation that is dependent on Xist RNA

    Article • Genes & Development, June 2011, Cold Spring Harbor Laboratory Press

    Professor Wouter de Laat, Dr ir Wilfred van IJcken

  26. An evolutionarily conserved three-dimensional structure in the vertebrate Irx clusters facilitates enhancer sharing and coregulation

    Article • Nature Communications, May 2011, Springer Science + Business Media

    Professor Wouter de Laat

  27. Diverse gene reprogramming events occur in the same spatial clusters of distal regulatory elements

    Article • Genome Research, April 2011, Cold Spring Harbor Laboratory Press

    Professor Wouter de Laat

  28. Integrated Transcript and Genome Analyses Reveal NKX2-1 and MEF2C as Potential Oncogenes in T Cell Acute Lymphoblastic Leukemia

    Article • Cancer Cell, April 2011, Elsevier

    Professor Wouter de Laat

  29. Interactions among Polycomb Domains Are Guided by Chromosome Architecture

    Article • PLoS Genetics, March 2011, PLOS

    Professor Wouter de Laat

  30. Genome organization influences partner selection for chromosomal rearrangements

    Article • Trends in Genetics, February 2011, Elsevier

    Professor Wouter de Laat

  31. High-resolution identification of balanced and complex chromosomal rearrangements by 4C technology

    Article • Nature Methods, October 2009, Springer Science + Business Media

    Professor Wouter de Laat

  32. Studying physical chromatin interactions in plants using Chromosome Conformation Capture (3C)

    Article • Nature Protocols, July 2009, Springer Science + Business Media

    Professor Wouter de Laat

  33. FISH-eyed and genome-wide views on the spatial organisation of gene expression

    Article • Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, November 2008, Elsevier

    Professor Wouter de Laat

  34. Joining the loops: β‐Globin gene regulation

    Article • IUBMB Life, September 2008, Wiley

    Professor Wouter de Laat

  35. Domain organization of human chromosomes revealed by mapping of nuclear lamina interactions

    Article • Nature, May 2008, Springer Science + Business Media

    Professor Wouter de Laat

  36. Transcription and Chromatin Organization of a Housekeeping Gene Cluster Containing an Integrated β-Globin Locus Control Region

    Article • PLoS Genetics, March 2008, PLOS

    Professor Wouter de Laat, Dr ir Wilfred van IJcken

  37. Maintenance of Long-Range DNA Interactions after Inhibition of Ongoing RNA Polymerase II Transcription

    Article • PLoS ONE, February 2008, PLOS

    Professor Wouter de Laat

  38. Chapter 5 Three‐Dimensional Organization of Gene Expression in Erythroid Cells

    Article • January 2008, Elsevier

    Professor Wouter de Laat

  39. Chapter 4 β‐Globin Regulation and Long‐Range Interactions

    Article • January 2008, Elsevier

    Professor Wouter de Laat

  40. An evaluation of 3C-based methods to capture DNA interactions

    Article • Nature Methods, October 2007, Springer Science + Business Media

    Professor Wouter de Laat

  41. Inter-chromosomal gene regulation in the mammalian cell nucleus

    Article • Current Opinion in Genetics & Development, October 2007, Elsevier

    Professor Wouter de Laat

  42. Quantitative analysis of chromosome conformation capture assays (3C-qPCR)

    Article • Nature Protocols, July 2007, Springer Science + Business Media

    Professor Wouter de Laat

  43. Long-range DNA contacts: romance in the nucleus?

    Article • Current Opinion in Cell Biology, June 2007, Elsevier

    Professor Wouter de Laat

  44. beta-Globin Active Chromatin Hub Formation in Differentiating Erythroid Cells and in p45 NF-E2 Knock-out Mice

    Article • Journal of Biological Chemistry, April 2007, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Wouter de Laat

  45. Reversible contraction by looping of the Tcra and Tcrb loci in rearranging thymocytes

    Article • Nature Immunology, March 2007, Springer Science + Business Media

    Professor Wouter de Laat

  46. Nuclear organization of active and inactive chromatin domains uncovered by chromosome conformation capture–on-chip (4C)

    Article • Nature Genetics, October 2006, Springer Science + Business Media

    Professor Wouter de Laat

  47. The β-globin nuclear compartment in development and erythroid differentiation

    Article • Nature Genetics, September 2003, Springer Science + Business Media

    Professor Wouter de Laat

  48. 3C Technology: Analyzing the Spatial Organization of Genomic Loci In Vivo

    Article • January 2003, Elsevier

    Professor Wouter de Laat

  49. Looping and Interaction between Hypersensitive Sites in the Active β-globin Locus

    Article • Molecular Cell, December 2002, Elsevier

    Professor Wouter de Laat

  50. Novel Functional Interactions between Nucleotide Excision DNA Repair Proteins Influencing the Enzymatic Activities of TFIIH, XPG, and ERCC1-XPF

    Article • Biochemistry, December 2000, American Chemical Society (ACS)

    Professor Wouter de Laat

  51. Molecular mechanism of nucleotide excision repair

    Article • Genes & Development, April 1999, Cold Spring Harbor Laboratory Press

    Professor Wouter de Laat

  52. Mapping of interaction domains between human repair proteins ERCC1 and XPF

    Article • Nucleic Acids Research, September 1998, Oxford University Press (OUP)

    Professor Wouter de Laat

  53. DNA-binding polarity of human replication protein A positions nucleases in nucleotide excision repair

    Article • Genes & Development, August 1998, Cold Spring Harbor Laboratory Press

    Professor Wouter de Laat

  54. DNA Structural Elements Required for ERCC1-XPF Endonuclease Activity

    Article • Journal of Biological Chemistry, April 1998, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Wouter de Laat

  55. Recombining DNA Damage Repair, Basal Transcription, and Human Syndromes

    Article • January 1997, Springer Science + Business Media

    Professor Wouter de Laat

  56. Xeroderma Pigmentosum Group F Caused by a Defect in a Structure-Specific DNA Repair Endonuclease

    Article • Cell, September 1996, Elsevier

    Professor Wouter de Laat