All Stories

  1. Human monocyte‐derived microglia‐like (iMG) cells: A tool to explore microglial dynamics
  2. Unexpected risk factors of pathological hikikomori during the COVID‐19 pandemic among working adults initially without social isolation: A longitudinal online survey
  3. Could the Construct of Modern-Type Depression Predict Internet Gaming Disorder in Italian Video Gamers? A Case–Control Study
  4. Youth hikikomori-like social withdrawal in Italy: Two clinical cases
  5. Development of depression assessment tools using humanoid robots -Can tele-operated robots talk with depressive persons like humans?
  6. Heterogeneity of gaming disorder: A clinically-based typology for developing personalized interventions
  7. Hikikomori and gaming disorder tendency: A case‐control online survey for non‐working adults
  8. TRPV4‐mediated Ca2+ deregulation causes mitochondrial dysfunction via the AKT/α‐synuclein pathway in dopaminergic neurons
  9. Analyzing changes in help-seeking from mental and physical health professionals during COVID-19 in Japan
  10. Holiday Internet Usage Time and the Risk of Internet Addiction Tendency among Working Adults in their 30s in Japan
  11. Hikikomori‐Like Social Withdrawal: An Italian Case Report
  12. High‐sensitivity C‐reactive protein and bilirubin as possible biomarkers for hikikomori in depression: a case–control study
  13. Clinical Usefulness of a Short Version of the Internet Addiction Test to Screen for Probable Internet Addiction in Adolescents with Autism Spectrum Disorder
  14. Preliminary analysis of hippocampus synaptic apoptosis and microglial phagocytosis induced by severe restraint stress
  15. A case of bipolar disorder with AIF1 (coding gene of Iba‐1) deletion: a pilot in vitro analysis using blood‐derived microglia‐like (iMG) cells
  16. One month version of Hikikomori Questionnaire‐25 ( HQ‐25M ): Development and initial validation
  17. Personality traits of female vocational school students in Japan with smartphone addiction with comorbid modern type depression traits
  18. Risk factors of hikikomori among office workers during the COVID-19 pandemic: A prospective online survey
  19. Mitochondrial Calcium-Triggered Oxidative Stress and Developmental Defects in Dopaminergic Neurons Differentiated from Deciduous Teeth-Derived Dental Pulp Stem Cells with MFF Insufficiency
  20. Machine Learning Algorithm-Based Prediction Model for the Augmented Use of Clozapine with Electroconvulsive Therapy in Patients with Schizophrenia
  21. Low-Density Lipoprotein Cholesterol Is a Possible Blood Biomarker of Schizoid Personality Traits among Females
  22. Network Analysis-Based Disentanglement of the Symptom Heterogeneity in Asian Patients with Schizophrenia: Findings from the Research on Asian Psychotropic Prescription Patterns for Antipsychotics
  23. Effects of COVID-19 on Mental Health in Business: Increasing the Hikikomori-Like Workers in Japan
  24. Psychodynamic group psychotherapy for hikikomori: The case of a socially withdrawn male with schizoaffective disorder
  25. Hyperbaric Oxygen Therapy for Carbon Monoxide-Induced Delayed Neuropsychiatric Sequelae: Case Report of Two Cases and Relevant Literature Review
  26. Blood metabolic signatures of hikikomori, pathological social withdrawal
  27. Involvement of microglia in disturbed fear memory regulation: Possible microglial contribution to the pathophysiology of posttraumatic stress disorder
  28. Autism Spectrum Conditions in Hikikomori: A Pilot Case–Control Study
  29. Forced social isolation due to COVID ‐19 and consequent mental health problems: lessons from hikikomori
  30. Network Analysis of the Depressive Symptom Profiles in Asian Patients with Depressive Disorders: Findings from the Research on Asian Psychotropic Prescription Patterns for Antidepressants (REAP‐AD)
  31. Improvement Of Frontal Lobe Dysfunction And White Matter Integrity By rTMS In Treatment-Resistant Depression
  32. Antidepressant effect of the translocator protein antagonist ONO-2952 on mouse behaviors under chronic social defeat stress
  33. Cuprizone-treated mice, a possible model of schizophrenia, highlighting the simultaneous abnormalities of GABA, serine and glycine in hippocampus
  34. Cannabis use correlates with aggressive behavior and long-acting injectable antipsychotic treatment in Asian patients with schizophrenia
  35. Establishing the cut-off score for aggression on the Brief Psychiatric Rating Scale-Excited Component (BPRS-EC) in schizophrenia patients
  36. Hikikomori: Multidimensional understanding, assessment and future international perspectives
  37. Development and validation of the 22‐item Tarumi's modern‐type depression trait scale; Avoidance of social roles, Complaint and low Self‐esteem (TACS‐22)
  38. Development and validation of the 25-item Hikikomori Questionnaire (HQ-25)
  39. Prevalence rate of Internet addiction among Japanese college students: Two cross-sectional studies and reconsideration of cut-off points of Young's Internet Addiction Test in Japan
  40. Does LINE addiction exist? Potential concerns about Japan's most popular form of social media on smartphones
  41. Harnessing Social Media to Explore Youth Social Withdrawal in Three Major Cities in China: Cross-Sectional Web Survey
  42. Is a Socio-Cultural Analysis of Depressive Disorders a Matter of Concern? Response to Kaiya
  43. Tryptophan-kynurenine and lipid related metabolites as blood biomarkers for first-episode drug-naïve patients with major depressive disorder: An exploratory pilot case-control study
  44. p66Shc Signaling Mediates Diabetes-Related Cognitive Decline
  45. Blood biomarkers of Hikikomori, a severe social withdrawal syndrome
  46. Hikikomori: experience in Japan and international relevance
  47. Development of a 2-h suicide prevention program for medical staff including nurses and medical residents: A two-center pilot trial
  48. Does hikikomori (severe social withdrawal) exist among young people in urban areas of China?
  49. Donepezil suppresses intracellular Ca2+ mobilization through the PI3K pathway in rodent microglia
  50. Early-onset epileptic encephalopathy and severe developmental delay in an association with de novo double mutations in NF1 and MAGEL2
  51. Modern-Type Depression as an “Adjustment” Disorder in Japan
  52. Dysregulated gene expressions of MEX3D, FOS and BCL2 in human induced-neuronal (iN) cells from NF1 patients: a pilot study
  53. Fibromyalgia and microglial TNF-α: Translational research using human blood induced microglia-like cells
  54. Suicidal ideation and burnout among psychiatric trainees in Japan
  55. Harnessing Social Media to Explore Youth Social Withdrawal in Three Major Cities in China: Cross-Sectional Web Survey (Preprint)
  56. Progressive brain atrophy and cognitive decline along with multiple episodes of delirium
  57. Microglia-derived neuregulin expression in psychiatric disorders
  58. Editorial: Minding Glial Cells in the Novel Understandings of Mental Illness
  59. Comparison of treatment patterns in schizophrenia between China and Japan (2001-2009)
  60. Microglial CD206 Gene Has Potential as a State Marker of Bipolar Disorder
  61. Effect of Excessive Coffee Consumption on the Clinical Course of a Patient With Bipolar Disorder
  62. Can Pokémon GO rescue shut-ins (hikikomori) from their isolated world?
  63. Plasma Metabolites Predict Severity of Depression and Suicidal Ideation in Psychiatric Patients-A Multicenter Pilot Analysis
  64. Aripiprazole inhibits polyI:C-induced microglial activation possibly via TRPM7
  65. New game software (Pokémon Go) may help youth with severe social withdrawal, hikikomori
  66. Directly Induced Glial/Neuronal Cells from Human Peripheral Tissues: A Novel Translational Research Tool for Neuropsychiatric Disorders
  67. Internet addiction and self-evaluated attention-deficit hyperactivity disorder traits among Japanese college students
  68. TNF-α from hippocampal microglia induces working memory deficits by acute stress in mice
  69. A 39-Year-Old “Adultolescent”: Understanding Social Withdrawal in Japan
  70. Boundless syndromes in modern society: An interconnected world producing novel psychopathology in the 21st century
  71. Neurocognitive Disorders in Chronic Kidney Disease: A Case Report and Literature Review
  72. Multidimensional anatomy of ‘modern type depression’ in Japan: A proposal for a different diagnostic approach to depression beyond the DSM-5
  73. Effectiveness of suicide prevention gatekeeper-training for university administrative staff in Japan
  74. Abnormal behaviours during pramipexole treatment for Cotard's syndrome: a case report
  75. A patient with Alzheimer's disease complicated by elderly-onset Cushing's syndrome who had undergone surgical treatment for adrenocorticotropic hormone-independent macronodular adrenal hyperplasia
  76. Psychopathology associated with social withdrawal: Idiopathic and comorbid presentations
  77. Introducing directly induced microglia-like (iMG) cells from fresh human monocytes: a novel translational research tool for psychiatric disorders
  78. MK-801 treatment affects glycolysis in oligodendrocytes more than in astrocytes and neuronal cells: insights for schizophrenia
  79. Relationship between Trusting Behaviors and Psychometrics Associated with Social Network and Depression among Young Generation: A Pilot Study
  80. Mania occurring during systemic lupus erythematosus relapse and its amelioration on clinical and neuroimaging follow-up
  81. Microglial intracellular Ca2+ signaling as a target of antipsychotic actions for the treatment of schizophrenia
  82. The prevalence and correlates of severe social withdrawal in Hong Kong
  83. Anti-allergic mechanisms of Japanese herbal medicine,yokukansanon mast cells
  84. Identification of the hikikomori syndrome of social withdrawal: Psychosocial features and treatment preferences in four countries
  85. Direct induction of ramified microglia-like cells from human monocytes: Dynamic microglial dysfunction in Nasu-Hakola disease
  86. Brain-derived Neurotrophic Factor (BDNF) Induces Sustained Intracellular Ca2+Elevation through the Up-regulation of Surface Transient Receptor Potential 3 (TRPC3) Channels in Rodent Microglia
  87. Minocycline, a Microglial Inhibitor, Diminishes Terminal Patients' Delirium?
  88. Why medical students choose psychiatry - a 20 country cross-sectional survey
  89. Neurodevelopmental and Neuropsychiatric Disorders
  90. Pretreatment of aripiprazole and minocycline, but not haloperidol, suppresses oligodendrocyte damage from interferon-γ-stimulated microglia in co-culture model
  91. Suicide Intervention Skills Among Japanese Medical Residents
  92. Undergraduate medical students’ attitudes towards psychiatry: An international cross-sectional survey between India and Japan
  93. Emerging devices for epilepsy
  94. Effectiveness of brief suicide management training programme for medical residents in Japan: a cluster randomized controlled trial
  95. Minocycline, a microglial inhibitor, reduces ‘honey trap’ risk in human economic exchange
  96. Neuroinflammation in schizophrenia especially focused on the role of microglia
  97. Nationwide Survey of Work Environment, Work-Life Balance and Burnout among Psychiatrists in Japan
  98. Missing and Possible Link between Neuroendocrine Factors, Neuropsychiatric Disorders, and Microglia
  99. Neuron-Glia Interaction as a Possible Glue to Translate the Mind-Brain Gap: A Novel Multi-Dimensional Approach Toward Psychology and Psychiatry (R1)
  100. Hikikomori as a possible clinical term in psychiatry: a questionnaire survey
  101. Minocycline Modulates Human Social Decision-Making: Possible Impact of Microglia on Personality-Oriented Social Behaviors
  102. Introducing the concept of modern depression in Japan; an international case vignette survey
  103. Does minocycline, an antibiotic with inhibitory effects on microglial activation, sharpen a sense of trust in social interaction?
  104. Are Japan's hikikomori and depression in young people spreading abroad?
  105. Aripiprazole inhibits superoxide generation from phorbol-myristate-acetate (PMA)-stimulated microglia in vitro: Implication for antioxidative psychotropic actions via microglia
  106. Does the ‘hikikomori’ syndrome of social withdrawal exist outside Japan? A preliminary international investigation
  107. Anti-Inflammatory Properties of Antipsychotics Via Microglia Modulations: Are Antipsychotics a ‘Fire Extinguisher’ in the Brain of Schizophrenia?
  108. Possible Role of BDNF-Induced Microglial Intracellular Ca2+ Elevation in the Pathophysiology of Neuropsychiatric Disorders
  109. Inhibitory effects of SSRIs on IFN-γ induced microglial activation through the regulation of intracellular calcium
  110. Successful treatment of chronic urticaria with a Japanese herbal medicine, yokukansan
  111. Impact of biopsychosocial factors on psychiatric training in Japan and overseas: Are psychiatrists oriented to mind, brain, or sociocultural issues?
  112. Development of 2-hour suicide intervention program among medical residents: First pilot trial
  113. Differences in the preferred antipsychotics for acute schizophrenia among young psychiatrists in two regions of Japan
  114. Attitudes of early-career psychiatrists in Japan toward child and adolescent psychiatry and their career decision
  115. Brain-Derived Neurotrophic Factor Induces Sustained Elevation of Intracellular Ca2+ in Rodent Microglia
  116. Cytokines and schizophrenia: Microglia hypothesis of schizophrenia
  117. Effect of yokukansan on the behavioral and psychological symptoms of dementia in elderly patients with Alzheimer's disease
  118. Attitude of young psychiatrists toward coercive measures in psychiatry: a case vignette study in Japan
  119. Inhibitory effects of aripiprazole on interferon--induced microglial activation via intracellular Ca2+regulationin vitro
  120. The effect of atypical antipsychotics, perospirone, ziprasidone and quetiapine on microglial activation induced by interferon-γ
  121. Antidepressants inhibit interferon-γ-induced microglial production of IL-6 and nitric oxide
  122. Risperidone significantly inhibits interferon-γ-induced microglial activation in vitro
  123. Phosphatidylserine and phosphatidylcholine-containing liposomes inhibit amyloid β and interferon-γ-induced microglial activation
  124. Phospholipids modulate superoxide and nitric oxide production by lipopolysaccharide and phorbol 12-myristate-13-acetate-activated microglia
  125. Interictal Psychosis After Stroke With Forced Normalization
  126. Different SPECT findings before and after Capgras’ syndrome in interictal psychosis
  127. Laminin and its Related Peptides for the Treatment of Alzheimers Disease