All Stories

  1. The identification of wadB, a new glycosyltransferase gene, confirms the branched structure and the role in virulence of the lipopolysaccharide core of Brucella abortus

    Article • Microbial Pathogenesis, August 2014, Elsevier

    Professor Ignacio Moriyon

  2. Brucellosis as an Emerging Threat in Developing Economies: Lessons from Nigeria

    Article • PLoS Neglected Tropical Diseases, July 2014, PLOS

    Professor Ignacio Moriyon

  3. Mutants in the lipopolysaccharide of Brucella ovis are attenuated and protect against B. ovis infection in mice

    Article • Veterinary Research, July 2014, Springer Science + Business Media

    Professor Ignacio Moriyon

  4. Brucella abortus Depends on Pyruvate Phosphate Dikinase and Malic Enzyme but Not on Fbp and GlpX Fructose-1,6-Bisphosphatases for Full Virulence in Laboratory Models

    Article • Journal of Bacteriology, June 2014, ASM Journals

    Professor Ignacio Moriyon

  5. Mutants in the lipopolysaccharide of

    Article • Veterinary Research, January 2014, Springer Science + Business Media

    Professor Ignacio Moriyon

  6. Performance of skin tests with allergens from B. melitensis B115 and rough B. abortus mutants for diagnosing swine brucellosis

    Article • Veterinary Microbiology, January 2014, Elsevier

    Professor Ignacio Moriyon

  7. Deletion of the GI-2 integrase and the wbkA flanking transposase improves the stability of Brucella melitensis Rev 1 vaccine

    Article • Veterinary Research, October 2013, Springer Science + Business Media

    Professor Ignacio Moriyon, Dr Marcos Mancilla

  8. Interactions of lipopolysaccharide with lipid membranes, raft models — A solid state NMR study

    Article • Biochimica et Biophysica Acta (BBA) - Biomembranes, August 2013, Elsevier

    Professor Ignacio Moriyon

  9. Lipopolysaccharide as a target for brucellosis vaccine design

    Article • Microbial Pathogenesis, May 2013, Elsevier

    Professor Ignacio Moriyon

  10. Lipopolysaccharides with Acylation Defects Potentiate TLR4 Signaling and Shape T Cell Responses

    Article • PLoS ONE, February 2013, PLOS

    Professor Ignacio Moriyon

  11. The Epitopic and Structural Characterization of Brucella suis Biovar 2 O-Polysaccharide Demonstrates the Existence of a New M-Negative C-Negative Smooth Brucella Serovar

    Article • PLoS ONE, January 2013, PLOS

    Professor Ignacio Moriyon

  12. Brucella β 1,2 Cyclic Glucan Is an Activator of Human and Mouse Dendritic Cells

    Article • PLoS Pathogens, November 2012, PLOS

    Professor Ignacio Moriyon, Helene Dutartre

  13. Comparative Genomics of Early-Diverging Brucella Strains Reveals a Novel Lipopolysaccharide Biosynthesis Pathway

    Article • mBio, November 2012, ASM Journals

    Professor Ignacio Moriyon

  14. Comparative Genomics of Early-Diverging Brucella Strains Reveals a Novel Lipopolysaccharide Biosynthesis Pathway

    Article • mBio, August 2012, ASM Journals

    Professor Ignacio Moriyon

  15. The Lipopolysaccharide Core of Brucella abortus Acts as a Shield Against Innate Immunity Recognition

    Article • PLoS Pathogens, May 2012, PLOS

    Professor Ignacio Moriyon, Roman Jerala

  16. What have we learned from brucellosis in the mouse model?

    Article • Veterinary Research, April 2012, Springer Science + Business Media

    Professor Ignacio Moriyon

  17. Spontaneous Excision of the O-Polysaccharide wbkA Glycosyltranferase Gene Is a Cause of Dissociation of Smooth to Rough Brucella Colonies

    Article • Journal of Bacteriology, February 2012, ASM Journals

    Professor Ignacio Moriyon, Dr Marcos Mancilla

  18. Identification and functional analysis of the cyclopropane fatty acid synthase of Brucella abortus

    Article • Microbiology, January 2012, Society for General Microbiology

    Professor Ignacio Moriyon

  19. Brucellosis at the animal/ecosystem/human interface at the beginning of the 21st century

    Article • Preventive Veterinary Medicine, November 2011, Elsevier

    Professor Ignacio Moriyon, Dr Pierre Wattiau

  20. Identification of new IS711 insertion sites in Brucella abortus field isolates

    Article • BMC Microbiology, August 2011, Springer Science + Business Media

    Professor Ignacio Moriyon, Dr Marcos Mancilla

  21. The Rose Bengal Test in Human Brucellosis: A Neglected Test for the Diagnosis of a Neglected Disease

    Article • PLoS Neglected Tropical Diseases, April 2011, PLOS

    Professor Ignacio Moriyon

  22. Brucella abortus Ornithine Lipids Are Dispensable Outer Membrane Components Devoid of a Marked Pathogen-Associated Molecular Pattern

    Article • PLoS ONE, January 2011, PLOS

    Professor Ignacio Moriyon

  23. Chapter 7 Brucellosis

    Article • January 2011, Oxford University Press (OUP)

    Professor Ignacio Moriyon

  24. Brucellosis seroprevalence in livestock in Uganda from 1998 to 2008: a retrospective study

    Article • Tropical Animal Health and Production, November 2010, Springer Science + Business Media

    Professor Ignacio Moriyon

  25. Structural Features Governing the Activity of Lactoferricin-Derived Peptides That Act in Synergy with Antibiotics againstPseudomonas aeruginosa In VitroandIn Vivo

    Article • Antimicrobial Agents and Chemotherapy, October 2010, ASM Journals

    Professor Ignacio Moriyon, Roman Jerala

  26. Genomic Island 2 Is an Unstable Genetic Element Contributing to Brucella Lipopolysaccharide Spontaneous Smooth-to-Rough Dissociation

    Article • Journal of Bacteriology, October 2010, ASM Journals

    Professor Ignacio Moriyon, Dr Marcos Mancilla

  27. New Antiseptic Peptides To Protect against Endotoxin-Mediated Shock

    Article • Antimicrobial Agents and Chemotherapy, July 2010, ASM Journals

    Professor Ignacio Moriyon

  28. Proteomics-based confirmation of protein expression and correction of annotation errors in the Brucella abortus genome

    Article • BMC Genomics, May 2010, Springer Science + Business Media

    Professor Ignacio Moriyon

  29. Eradication of bovine brucellosis in the Azores, Portugal—Outcome of a 5-year programme (2002–2007) based on test-and-slaughter and RB51 vaccination

    Article • Preventive Veterinary Medicine, April 2010, Elsevier

    Professor Ignacio Moriyon

  30. Effective Antimicrobial and Anti-Endotoxin Activity of Cationic Peptides Based on Lactoferricin: A Biophysical and Microbiological Study

    Article • Anti-Infective Agents in Medicinal Chemistry, January 2010, Bentham Science Publishers

    Professor Ignacio Moriyon

  31. Structural prerequisites for endotoxic activity in the Limulus test as compared to cytokine production in mononuclear cells

    Article • Innate Immunity, June 2009, SAGE Publications

    Professor Ignacio Moriyon

  32. The Differential Interaction of Brucella and Ochrobactrum with Innate Immunity Reveals Traits Related to the Evolution of Stealthy Pathogens

    Article • PLoS ONE, June 2009, PLOS

    Professor Ignacio Moriyon, Roman Jerala

  33. Rough mutants defective in core and O-polysaccharide synthesis and export induce antibodies reacting in an indirect ELISA with smooth lipopolysaccharide and are less effective than Rev 1 vaccine against Brucella melitensis infection of sheep

    Article • Vaccine, March 2009, Elsevier

    Professor Ignacio Moriyon, Letesson Jean-Jacques

  34. Is Brucella an enteric pathogen?

    Article • Nature Reviews Microbiology, January 2009, Springer Science + Business Media

    Professor Ignacio Moriyon

  35. DNA polymorphism analysis of Brucella lipopolysaccharide genes reveals marked differences in O-polysaccharide biosynthetic genes between smooth and rough Brucella species and novel species-specific markers

    Article • BMC Microbiology, January 2009, Springer Science + Business Media

    Professor Ignacio Moriyon, Letesson Jean-Jacques

  36. Comparative analysis of selected methods for the assessment of antimicrobial and membrane-permeabilizing activity: a case study for lactoferricin derived peptides

    Article • BMC Microbiology, November 2008, Springer Science + Business Media

    Professor Ignacio Moriyon, Roman Jerala

  37. Brucellosis Vaccines: Assessment of Brucella melitensis Lipopolysaccharide Rough Mutants Defective in Core and O-Polysaccharide Synthesis and Export

    Article • PLoS ONE, July 2008, PLOS

    Professor Ignacio Moriyon, Letesson Jean-Jacques

  38. Mechanism of interaction of optimized Limulus -derived cyclic peptides with endotoxins: thermodynamic, biophysical and microbiological analysis

    Article • Biochemical Journal, September 2007, Portland Press Ltd.

    Professor Ignacio Moriyon

  39. BvrR/BvrS-Controlled Outer Membrane Proteins Omp3a and Omp3b Are Not Essential for Brucella abortus Virulence

    Article • Infection and Immunity, July 2007, ASM Journals

    Professor Ignacio Moriyon

  40. Brucella abortus Uses a Stealthy Strategy to Avoid Activation of the Innate Immune System during the Onset of Infection

    Article • PLoS ONE, July 2007, PLOS

    Professor Ignacio Moriyon

  41. Thermodynamic Analysis of the Lipopolysaccharide-Dependent Resistance of Gram-Negative Bacteria against Polymyxin B

    Article • Biophysical Journal, April 2007, Elsevier

    Professor Ignacio Moriyon

  42. Rationale for the Design of Shortened Derivatives of the NK-lysin-derived Antimicrobial Peptide NK-2 with Improved Activity against Gram-negative Pathogens

    Article • Journal of Biological Chemistry, March 2007, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Ignacio Moriyon, Professor Torsten Goldmann

  43. Extensive Cell Envelope Modulation Is Associated with Virulence in Brucella abortus

    Article • Journal of Proteome Research, March 2007, American Chemical Society (ACS)

    Professor Ignacio Moriyon

  44. The Acyl Group as the Central Element of the Structural Organization of Antimicrobial Lipopeptide

    Article • Journal of the American Chemical Society, January 2007, American Chemical Society (ACS)

    Professor Ignacio Moriyon, Roman Jerala

  45. Synthesis of phosphatidylcholine, a typical eukaryotic phospholipid, is necessary for full virulence of the intracellular bacterial parasite Brucella abortus

    Article • Cellular Microbiology, August 2006, Hindawi Publishing Corporation

    Professor Ignacio Moriyon

  46. Increases of efficacy as vaccine against Brucella abortus infection in mice by simultaneous inoculation with avirulent smooth bvrS/bvrR and rough wbkA mutants

    Article • Vaccine, April 2006, Elsevier

    Professor Ignacio Moriyon

  47. Differential inductions of TNF-alpha and IGTP, IIGP by structurally diverse classic and non-classic lipopolysaccharides

    Article • Cellular Microbiology, March 2006, Hindawi Publishing Corporation

    Professor Ignacio Moriyon, Osamu Takeuchi

  48. Brucella: Molecular and Cellular Biology Edited by Ignacio Lopez-Goni and Ignacio Moriyon Wymondham, UK: Horizon Bioscience, 2004. 432 pp., illustrated. $200.00 (cloth)

    Article • Clinical Infectious Diseases, February 2006, Oxford University Press (OUP)

    Professor Ignacio Moriyon

  49. Characterization of Brucella abortus lipopolysaccharide macrodomains as mega rafts

    Article • Cellular Microbiology, February 2006, Hindawi Publishing Corporation

    Professor Ignacio Moriyon

  50. The Genus Brucella

    Article • January 2006, Springer Science + Business Media

    Professor Ignacio Moriyon

  51. Comparing Antimicrobial and Membrane Permeabilizing Activity of Peptides Derived from Human Cationic Proteins

    Article • January 2006, Springer Science + Business Media

    Professor Ignacio Moriyon

  52. The Lipopolysaccharide of Brucella abortus BvrS/BvrR Mutants Contains Lipid A Modifications and Has Higher Affinity for Bactericidal Cationic Peptides

    Article • Journal of Bacteriology, August 2005, ASM Journals

    Professor Ignacio Moriyon

  53. Cyclic β-1,2-glucan is a brucella virulence factor required for intracellular survival

    Article • Nature Immunology, May 2005, Springer Science + Business Media

    Professor Ignacio Moriyon

  54. Brucella lipopolysaccharide acts as a virulence factor

    Article • Current Opinion in Microbiology, February 2005, Elsevier

    Professor Ignacio Moriyon

  55. Enhancement of endotoxin neutralization by coupling of a C12-alkyl chain to a lactoferricin-derived peptide

    Article • Biochemical Journal, January 2005, Portland Press Ltd.

    Professor Ignacio Moriyon, Roman Jerala

  56. Efficacy of Several Serological Tests and Antigens for Diagnosis of Bovine Brucellosis in the Presence of False-Positive Serological Results Due to Yersinia enterocolitica O:9

    Article • Clinical and Diagnostic Laboratory Immunology, January 2005, ASM Journals

    Professor Ignacio Moriyon, Professor Raul C Mainar-Jaime

  57. Characterization of Brucella abortus O-Polysaccharide and Core Lipopolysaccharide Mutants and Demonstration that a Complete Core Is Required for Rough Vaccines To Be Efficient against Brucella abortus and Brucella ovis in the Mouse Model

    Article • Infection and Immunity, June 2003, ASM Journals

    Professor Ignacio Moriyon

  58. Pathogenic Yersinia enterocolitica Strains Increase the Outer Membrane Permeability in Response to Environmental Stimuli by Modulating Lipopolysaccharide Fluidity and Lipid A Structure

    Article • Infection and Immunity, April 2003, ASM Journals

    Professor Ignacio Moriyon

  59. Brucella evolution and taxonomy

    Article • Veterinary Microbiology, December 2002, Elsevier

    Professor Ignacio Moriyon

  60. Regulation of Brucella virulence by the two-component system BvrR/BvrS

    Article • Veterinary Microbiology, December 2002, Elsevier

    Professor Ignacio Moriyon

  61. The interaction of rough and smooth form lipopolysaccharides with polymyxins as studied by titration calorimetry

    Article • Thermochimica Acta, October 2002, Elsevier

    Professor Ignacio Moriyon

  62. The two-component system BvrR/BvrS essential for Brucella abortus virulence regulates the expression of outer membrane proteins with counterparts in members of the Rhizobiaceae

    Article • Proceedings of the National Academy of Sciences, September 2002, Proceedings of the National Academy of Sciences

    Professor Ignacio Moriyon

  63. Brucella melitensis : A nasty bug with hidden credentials for virulence

    Article • Proceedings of the National Academy of Sciences, January 2002, Proceedings of the National Academy of Sciences

    Professor Ignacio Moriyon

  64. Biophysical investigations into the interaction of lipopolysaccharide with polymyxins

    Article • Thermochimica Acta, January 2002, Elsevier

    Professor Ignacio Moriyon

  65. Brucella abortus and Its Closest Phylogenetic Relative, Ochrobactrum spp., Differ in Outer Membrane Permeability and Cationic Peptide Resistance

    Article • Infection and Immunity, June 2000, ASM Journals

    Professor Ignacio Moriyon

  66. The lipopolysaccharide outer core of Yersinia enterocolitica serotype O:3 is required for virulence and plays a role in outer membrane integrity

    Article • Molecular Microbiology, March 1999, Wiley

    Professor Ignacio Moriyon

  67. Comparison of polyclonal, monoclonal and protein G peroxidase conjugates in an enzyme‐linked immunosorbent assay for the diagnosis of Brucella ovis in sheep

    Article • Veterinary Record, October 1998, Wiley

    Professor Ignacio Moriyon

  68. A two‐component regulatory system playing a critical role in plant pathogens and endosymbionts is present in Brucella abortus and controls cell invasion and virulence

    Article • Molecular Microbiology, July 1998, Wiley

    Professor Ignacio Moriyon, Dr Javier Pizarro-Cerda

  69. Evaluation of the relatedness of Brucella spp. and Ochrobactrum anthropi and description of Ochrobactrum intermedium sp. nov., a new species with a closer relationship to Brucella spp.

    Article • International Journal of Systematic Bacteriology, July 1998, Society for General Microbiology

    Professor Ignacio Moriyon

  70. Yersinia pseudotuberculosis and Yersinia pestis show increased outer membrane permeability to hydrophobic agents which correlates with lipopolysaccharide acyl-chain fluidity

    Article • Microbiology, June 1998, Society for General Microbiology

    Professor Ignacio Moriyon

  71. Diagnosis and epidemiology of Brucella ovis infection in rams

    Article • Small Ruminant Research, June 1998, Elsevier

    Professor Ignacio Moriyon

  72. Structural studies on the lipopolysaccharide from a rough strain of Ochrobactrum anthropi containing a 2,3-diamino-2,3-dideoxy-d-glucose disaccharide lipid A backbone

    Article • Carbohydrate Research, January 1998, Elsevier

    Professor Ignacio Moriyon

  73. Determination of the O-specific polysaccharide structure in the lipopolysaccharide of Ochrobactrum anthropi LMG 3331

    Article • Carbohydrate Research, June 1996, Elsevier

    Professor Ignacio Moriyon

  74. Diagnosis of Brucella ovis infection of rams with an ELISA using protein G as conjugate

    Article • Veterinary Record, August 1995, Wiley

    Professor Ignacio Moriyon

  75. Evaluation of whole cell and subcellular vaccines against Brucella ovis in rams

    Article • Veterinary Immunology and Immunopathology, August 1993, Elsevier

    Professor Ignacio Moriyon, Professor Carlos Gamazo

  76. An ELISA with Brucella lipopolysaccharide antigen for the diagnosis of B. melitensis infection in sheep and for the evaluation of serological responses following subcutaneous or conjunctival B. melitensis strain Rev 1 vaccination

    Article • Veterinary Microbiology, February 1992, Elsevier

    Professor Ignacio Moriyon, Professor Carlos Gamazo

  77. Comparison of three serological tests for Brucella ovis infection of rams using different antigenic extracts

    Article • Veterinary Record, November 1989, Wiley

    Professor Ignacio Moriyon, Professor Carlos Gamazo

  78. Immunization with Brucella melitensis Rev 1 against Brucella ovis infection of rams

    Article • Veterinary Microbiology, September 1987, Elsevier

    Professor Ignacio Moriyon

  79. Properties of the outer membrane of Brucella

    Article • Annales de l Institut Pasteur Microbiologie, January 1987, Elsevier

    Professor Ignacio Moriyon, Professor Carlos Gamazo

  80. In vitro interactions between lipopolysaccharides and heterologous outer membrane porin proteins

    Article • Current Microbiology, July 1985, Springer Science + Business Media

    Professor Ignacio Moriyon

  81. Torulopsis navarrensis sp. nov. A new species of yeast isolated from an acid washed brown soil in the province of Navarra, Spain

    Article • Mycopathologia, January 1978, Springer Science + Business Media

    Professor Ignacio Moriyon