All Stories

  1. Stat3 in intestinal regeneration and tumorigenesis

    Article • The FASEB Journal, February 2019, Federation of American Societies For Experimental Biology (FASEB)

    Masanobu Oshima, Sau-Yee Kok

  2. NF-κB-induced NOX1 activation promotes gastric tumorigenesis through the expansion of SOX2-positive epithelial cells

    Article • Oncogene, January 2019, Springer Science + Business Media

    Masanobu Oshima

  3. Mutant p53 in colon cancer

    Article • Journal of Molecular Cell Biology, November 2018, Oxford University Press (OUP)

    Masanobu Oshima

  4. Dietary intake of pyrolyzed deketene curcumin inhibits gastric carcinogenesis

    Article • Journal of Functional Foods, November 2018, Elsevier

    Masanobu Oshima

  5. Author Correction: Estrogen-related receptor gamma functions as a tumor suppressor in gastric cancer

    Article • Nature Communications, August 2018, Springer Science + Business Media

    Masanobu Oshima

  6. Estrogen-related receptor gamma functions as a tumor suppressor in gastric cancer

    Article • Nature Communications, May 2018, Springer Science + Business Media

    Masanobu Oshima

  7. Spred1 Safeguards Hematopoietic Homeostasis against Diet-Induced Systemic Stress

    Article • Cell Stem Cell, May 2018, Elsevier

    Masanobu Oshima

  8. The inflammatory microenvironment that promotes gastrointestinal cancer development and invasion

    Article • Advances in Biological Regulation, May 2018, Elsevier

    Masanobu Oshima

  9. Hyperactive gp130/STAT3-driven gastric tumourigenesis promotes submucosal tertiary lymphoid structure development

    Article • International Journal of Cancer, February 2018, Wiley

    Masanobu Oshima

  10. Functional loss of p53 cooperates with the in vivo microenvironment to promote malignant progression of gastric cancers

    Article • Scientific Reports, February 2018, Springer Science + Business Media

    Masanobu Oshima

  11. Clinical Utility of a STAT3-Regulated miRNA-200 Family Signature with Prognostic Potential in Early Gastric Cancer

    Article • Clinical Cancer Research, January 2018, American Association for Cancer Research (AACR)

    Masanobu Oshima

  12. Stemness Is Enhanced in Gastric Cancer by a SET/PP2A/E2F1 Axis

    Article • Molecular Cancer Research, January 2018, American Association for Cancer Research (AACR)

    Masanobu Oshima

  13. Laser Microdissection of Cellular Compartments for Expression Analyses in Cancer Models

    Article • January 2018, Springer Science + Business Media

    Masanobu Oshima

  14. Combined Mutation ofApc, Kras, andTgfbr2Effectively Drives Metastasis of Intestinal Cancer

    Article • Cancer Research, December 2017, American Association for Cancer Research (AACR)

    Masanobu Oshima

  15. Inflammasome Adaptor ASC Suppresses Apoptosis of Gastric Cancer Cells by an IL18-Mediated Inflammation-Independent Mechanism

    Article • Cancer Research, December 2017, American Association for Cancer Research (AACR)

    Masanobu Oshima

  16. A novel role for OATP2A1/SLCO2A1 in a murine model of colon cancer

    Article • Scientific Reports, November 2017, Springer Science + Business Media

    Takeo Nakanishi, Masanobu Oshima

  17. Requisite role of vasohibin-2 in spontaneous gastric cancer formation and accumulation of cancer-associated fibroblasts

    Article • Cancer Science, October 2017, Wiley

    Masanobu Oshima

  18. Intestinal cancer progression by mutant p53 through the acquisition of invasiveness associated with complex glandular formation

    Article • Oncogene, June 2017, Springer Science + Business Media

    Masanobu Oshima

  19. Identification of a TLR2-regulated gene signature associated with tumor cell growth in gastric cancer

    Article • Oncogene, May 2017, Springer Science + Business Media

    Masanobu Oshima

  20. Cell competition with normal epithelial cells promotes apical extrusion of transformed cells through metabolic changes

    Article • Nature Cell Biology, April 2017, Springer Science + Business Media

    Masanobu Oshima

  21. Nardilysin regulates inflammation, metaplasia and tumors in murine stomach

    Article • Scientific Reports, February 2017, Springer Science + Business Media

    Masanobu Oshima

  22. Gut Microbiota Promotes Obesity-Associated Liver Cancer through PGE 2 -Mediated Suppression of Antitumor Immunity

    Article • Cancer Discovery, February 2017, American Association for Cancer Research (AACR)

    Masanobu Oshima

  23. 18β-glycyrrhetinic acid suppresses gastric cancer by activation of miR-149-3p-Wnt-1 signaling

    Article • Oncotarget, October 2016, Impact Journals, LLC

    Masanobu Oshima

  24. Inflammation in gastric cancer: Interplay of the COX‐2/prostaglandin E 2 and Toll‐like receptor/MyD88 pathways

    Article • Cancer Science, March 2016, Wiley

    Dr. Yusuke Maeda, Masanobu Oshima

  25. Myeloid Differentiation Factor 88 Signaling in Bone Marrow-Derived Cells Promotes Gastric Tumorigenesis by Generation of Inflammatory Microenvironment

    Article • Cancer Prevention Research, February 2016, American Association for Cancer Research (AACR)

    Masanobu Oshima

  26. NOTUM is a potential pharmacodynamic biomarker of Wnt pathway inhibition

    Article • Oncotarget, February 2016, Impact Journals, LLC

    Masanobu Oshima

  27. Dipeptide species regulate p38MAPK–Smad3 signalling to maintain chronic myelogenous leukaemia stem cells

    Article • Nature Communications, August 2015, Springer Science + Business Media

    Masanobu Oshima

  28. Ink4a/Arf-Dependent Loss of Parietal Cells Induced by Oxidative Stress Promotes CD44-Dependent Gastric Tumorigenesis

    Article • Cancer Prevention Research, March 2015, American Association for Cancer Research (AACR)

    Masanobu Oshima

  29. Canolol Inhibits Gastric Tumors Initiation and Progression through COX-2/PGE2 Pathway in K19-C2mE Transgenic Mice

    Article • PLoS ONE, March 2015, PLOS

    Masanobu Oshima

  30. Suppressing TGF  Signaling in Regenerating Epithelia in an Inflammatory Microenvironment Is Sufficient to Cause Invasive Intestinal Cancer

    Article • Cancer Research, February 2015, American Association for Cancer Research (AACR)

    Masanobu Oshima

  31. PGE2-Associated Inflammation and Gastrointestinal Tumorigenesis

    Article • January 2015, Springer Science + Business Media

    Masanobu Oshima

  32. Therapeutic activity of glycoengineered anti‐ GM 2 antibodies against malignant pleural mesothelioma

    Article • Cancer Science, December 2014, Wiley

    Masanobu Oshima

  33. Inhibition of β-catenin and STAT3 with a curcumin analog suppresses gastric carcinogenesis in vivo

    Article • Gastric Cancer, October 2014, Springer Science + Business Media

    Masanobu Oshima

  34. MicroRNA-29c mediates initiation of gastric carcinogenesis by directly targeting ITGB1

    Article • Gut, May 2014, BMJ

    Masanobu Oshima

  35. Context‐dependent activation of Wnt signaling by tumor suppressor RUNX3 in gastric cancer cells

    Article • Cancer Science, February 2014, Wiley

    Masanobu Oshima

  36. Impact of Inflammation–Metaplasia–Adenocarcinoma Sequence and Inflammatory Microenvironment in Esophageal Carcinogenesis Using Surgical Rat Models

    Article • Annals of Surgical Oncology, February 2014, Springer Science + Business Media

    Masanobu Oshima

  37. Requirement of SLD5 for Early Embryogenesis

    Article • PLoS ONE, November 2013, PLOS

    Masanobu Oshima

  38. TNF-α/TNFR1 signaling promotes gastric tumorigenesis through induction of Noxo1 and Gna14 in tumor cells

    Article • Oncogene, August 2013, Springer Science + Business Media

    Masanobu Oshima

  39. Functional role of CD44v-xCT system in the development of spasmolytic polypeptide-expressing metaplasia

    Article • Cancer Science, August 2013, Wiley

    Masanobu Oshima

  40. Claudin-4 Deficiency Results in Urothelial Hyperplasia and Lethal Hydronephrosis

    Article • PLoS ONE, December 2012, PLOS

    Masanobu Oshima

  41. Validation of MIMGO: a method to identify differentially expressed GO terms in a microarray dataset

    Article • BMC Research Notes, December 2012, Springer Science + Business Media

    Masanobu Oshima

  42. Toll-like receptor 2: therapeutic target for gastric carcinogenesis

    Article • Oncotarget, November 2012, Impact Journals, LLC

    Masanobu Oshima

  43. The unfolded protein response is activated in Helicobacter-induced gastric carcinogenesis in a non-cell autonomous manner

    Article • Laboratory Investigation, October 2012, Springer Science + Business Media

    Masanobu Oshima

  44. The role of PGE2-associated inflammatory responses in gastric cancer development

    Article • Seminars in Immunopathology, October 2012, Springer Science + Business Media

    Masanobu Oshima

  45. STAT3-Driven Upregulation of TLR2 Promotes Gastric Tumorigenesis Independent of Tumor Inflammation

    Article • Cancer Cell, October 2012, Elsevier

    Masanobu Oshima

  46. The inflammatory network in the gastrointestinal tumor microenvironment: lessons from mouse models

    Article • Journal of Gastroenterology, January 2012, Springer Science + Business Media

    Masanobu Oshima

  47. Inflammation-induced repression of tumor suppressor miR-7 in gastric tumor cells

    Article • Oncogene, December 2011, Springer Science + Business Media

    Masanobu Oshima

  48. Activation of Bmp2-Smad1 Signal and Its Regulation by Coordinated Alteration of H3K27 Trimethylation in Ras-Induced Senescence

    Article • PLoS Genetics, November 2011, PLOS

    Masanobu Oshima

  49. CD44 Variant Regulates Redox Status in Cancer Cells by Stabilizing the xCT Subunit of System xc− and Thereby Promotes Tumor Growth

    Article • Cancer Cell, March 2011, Elsevier

    Masanobu Oshima

  50. Activation of epidermal growth factor receptor signaling by the prostaglandin E2 receptor EP4 pathway during gastric tumorigenesis

    Article • Cancer Science, February 2011, Wiley

    Masanobu Oshima

  51. Prostaglandin E2 Signaling and Bacterial Infection Recruit Tumor-Promoting Macrophages to Mouse Gastric Tumors

    Article • Gastroenterology, February 2011, Elsevier

    Masanobu Oshima

  52. Adenomatous polyposis coli heterozygous knockout mice display hypoactivity and age-dependent working memory deficits

    Article • Frontiers in Behavioral Neuroscience, January 2011, Frontiers

    Masanobu Oshima, Tsuyoshi Miyakawa

  53. Suppression of Colon Cancer Metastasis by Aes through Inhibition of Notch Signaling

    Article • Cancer Cell, January 2011, Elsevier

    Masanobu Oshima, Prof. Dr. Haruhiko Fuwa, Dr Hiroki Hashida

  54. Cox-2 deletion in myeloid and endothelial cells, but not in epithelial cells, exacerbates murine colitis.

    Article • Carcinogenesis, December 2010, Oxford University Press (OUP)

    Masanobu Oshima

  55. Mouse models of gastric tumors: Wnt activation and PGE2 induction

    Article • Pathology International, July 2010, Wiley

    Masanobu Oshima

  56. Inflammation, tumor necrosis factor and Wnt promotion in gastric cancer development

    Article • Future Oncology, April 2010, Future Medicine

    Masanobu Oshima

  57. CD44+slow-cycling tumor cell expansion is triggered by cooperative actions of Wnt and prostaglandin E2in gastric tumorigenesis

    Article • Cancer Science, March 2010, Wiley

    Masanobu Oshima

  58. Hepatocellular carcinoma development induced by conditional β-catenin activation inLkb1+/−mice

    Article • Cancer Science, November 2009, Wiley

    Masanobu Oshima

  59. Identification of tumor-initiating cells in a highly aggressive brain tumor using promoter activity of nucleostemin

    Article • Proceedings of the National Academy of Sciences, October 2009, Proceedings of the National Academy of Sciences

    Masanobu Oshima

  60. Prostaglandin E2, Wnt, and BMP in gastric tumor mouse models

    Article • Cancer Science, October 2009, Wiley

    Masanobu Oshima

  61. HMGA1 Is Induced by Wnt/β-Catenin Pathway and Maintains Cell Proliferation in Gastric Cancer

    Article • American Journal Of Pathology, October 2009, Elsevier

    Masanobu Oshima

  62. Induction and Down-regulation of Sox17 and Its Possible Roles During the Course of Gastrointestinal Tumorigenesis

    Article • Gastroenterology, October 2009, Elsevier

    Masanobu Oshima

  63. Induction of Prostaglandin E2 Pathway Promotes Gastric Hamartoma Development with Suppression of Bone Morphogenetic Protein Signaling

    Article • Cancer Research, March 2009, American Association for Cancer Research (AACR)

    Masanobu Oshima

  64. The Interleukin-6 Family Cytokine Interleukin-11 Regulates Homeostatic Epithelial Cell Turnover and Promotes Gastric Tumor Development

    Article • Gastroenterology, March 2009, Elsevier

    Masanobu Oshima

  65. Prostaglandin and Transforming Growth Factor β Signaling in Gastric Cancer

    Article • January 2009, Springer Science + Business Media

    Masanobu Oshima

  66. Mouse gastric tumor models with prostaglandin E2 pathway activation show similar gene expression profiles to intestinal-type human gastric cancer

    Article • BMC Genomics, January 2009, Springer Science + Business Media

    Masanobu Oshima

  67. Roles of cyclooxygenase-2 and microsomal prostaglandin E synthase-1 expression and β-catenin activation in gastric carcinogenesis inN-methyl-N-nitrosourea-treated K19-C2mE transgenic mice

    Article • Cancer Science, December 2008, Wiley

    Masanobu Oshima

  68. Matrix metalloproteinase 7 is required for tumor formation, but dispensable for invasion and fibrosis in SMAD4-deficient intestinal adenocarcinomas

    Article • Laboratory Investigation, November 2008, Springer Science + Business Media

    Masanobu Oshima

  69. Activated macrophages promote Wnt signalling through tumour necrosis factor-α in gastric tumour cells

    Article • The EMBO Journal, May 2008, Wiley

    Masanobu Oshima

  70. Stromal Fibroblasts Activated by Tumor Cells Promote Angiogenesis in Mouse Gastric Cancer

    Article • Journal of Biological Chemistry, May 2008, American Society for Biochemistry & Molecular Biology (ASBMB)

    Masanobu Oshima

  71. Blocking TNF-α in mice reduces colorectal carcinogenesis associated with chronic colitis

    Article • Journal of Clinical Investigation, January 2008, American Society for Clinical Investigation

    Masanobu Oshima

  72. Platelet-type 12-lipoxygenase accelerates tumor promotion of mouse epidermal cells through enhancement of cloning efficiency

    Article • Carcinogenesis, January 2008, Oxford University Press (OUP)

    Masanobu Oshima

  73. Suppression of Tubulin Polymerization by the LKB1-Microtubule-associated Protein/Microtubule Affinity-regulating Kinase Signaling

    Article • Journal of Biological Chemistry, June 2007, American Society for Biochemistry & Molecular Biology (ASBMB)

    Masanobu Oshima

  74. SMAD4-deficient intestinal tumors recruit CCR1+ myeloid cells that promote invasion

    Article • Nature Genetics, March 2007, Springer Science + Business Media

    Masanobu Oshima, Dr Hiroki Hashida

  75. Chemokine receptor CXCR3 promotes colon cancer metastasis to lymph nodes

    Article • Oncogene, February 2007, Springer Science + Business Media

    Masanobu Oshima

  76. Increased Level of Serum Vascular Endothelial Growth Factor by Long-Term Exposure to Hypergravity

    Article • EXPERIMENTAL ANIMALS, January 2007, Japanese Association for Laboratory Animal Science

    Masanobu Oshima

  77. Chromosomal instability by β-catenin/TCF transcription in APC or β-catenin mutant cells

    Article • Oncogene, December 2006, Springer Science + Business Media

    Masanobu Oshima

  78. Carcinogenesis in Mouse Stomach by Simultaneous Activation of the Wnt Signaling and Prostaglandin E2 Pathway

    Article • Gastroenterology, October 2006, Elsevier

    Masanobu Oshima

  79. Destruction of Pancreatic β-Cells by Transgenic Induction of Prostaglandin E2in the Islets

    Article • Journal of Biological Chemistry, July 2006, American Society for Biochemistry & Molecular Biology (ASBMB)

    Masanobu Oshima

  80. Accelerated onsets of gastric hamartomas and hepatic adenomas/carcinomas in Lkb1+/−p53−/− compound mutant mice

    Article • Oncogene, November 2005, Springer Science + Business Media

    Masanobu Oshima

  81. Hyperplastic Gastric Tumors with Spasmolytic Polypeptide–Expressing Metaplasia Caused by Tumor Necrosis Factor-α–Dependent Inflammation in Cyclooxygenase-2/Microsomal Prostaglandin E Synthase-1 Transgenic Mice

    Article • Cancer Research, October 2005, American Association for Cancer Research (AACR)

    Masanobu Oshima

  82. The Threshold Level of Adenomatous Polyposis Coli Protein for Mouse Intestinal Tumorigenesis

    Article • Cancer Research, October 2005, American Association for Cancer Research (AACR)

    Masanobu Oshima

  83. Hypergravity induces expression of cyclooxygenase-2 in the heart vessels

    Article • Biochemical and Biophysical Research Communications, May 2005, Elsevier

    Masanobu Oshima

  84. ROCK-I regulates closure of the eyelids and ventral body wall by inducing assembly of actomyosin bundles

    Article • Journal of Cell Biology, March 2005, Rockefeller University Press

    Masanobu Oshima

  85. A Targeted Mutation of Nkd1 Impairs Mouse Spermatogenesis

    Article • Journal of Biological Chemistry, November 2004, American Society for Biochemistry & Molecular Biology (ASBMB)

    Masanobu Oshima

  86. Development of spontaneous tumours and intestinal lesions in Fhit gene knockout mice

    Article • British Journal of Cancer, October 2004, Springer Science + Business Media

    Masanobu Oshima

  87. Pivotal Role of CXCR3 in Melanoma Cell Metastasis to Lymph Nodes

    Article • Cancer Research, June 2004, American Association for Cancer Research (AACR)

    Masanobu Oshima

  88. Hyperplastic gastric tumors induced by activated macrophages in COX-2/mPGES-1 transgenic mice

    Article • The EMBO Journal, March 2004, Wiley

    Masanobu Oshima

  89. Simultaneous expression of COX-2 and mPGES-1 in mouse gastrointestinal hamartomas

    Article • British Journal of Cancer, February 2004, Springer Science + Business Media

    Masanobu Oshima

  90. Hepatocarcinogenesis in Mice with β-Catenin and Ha-Ras Gene Mutations

    Article • Cancer Research, January 2004, American Association for Cancer Research (AACR)

    Masanobu Oshima

  91. Colonic polyposis caused by mTOR-mediated chromosomal instability in Apc+/Δ716 Cdx2 +/− compound mutant mice

    Article • Nature Genetics, November 2003, Springer Science + Business Media

    Masanobu Oshima

  92. Targeted Disruption of the Mouse Rho-Associated Kinase 2 Gene Results in Intrauterine Growth Retardation and Fetal Death

    Article • Molecular and Cellular Biology, July 2003, ASM Journals

    Masanobu Oshima

  93. Requirement for tumor suppressor Apc in the morphogenesis of anterior and ventral mouse embryo

    Article • Developmental Biology, January 2003, Elsevier

    Masanobu Oshima

  94. COX Selectivity and Animal Models for Colon Cancer

    Article • Current Pharmaceutical Design, June 2002, Bentham Science Publishers

    Masanobu Oshima

  95. COX inhibitor, suppression of polyposis, and chemoprevention.

    Article • Folia Pharmacologica Japonica, January 2002, Japanese Pharmacological Society

    Masanobu Oshima

  96. Acceleration of intestinal polyposis through prostaglandin receptor EP2 in Apc Δ716 knockout mice

    Article • Nature Medicine, September 2001, Springer Science + Business Media

    Masanobu Oshima

  97. Morphologic and Molecular Analysis of Estrogen-Induced Pituitary Tumorigenesis in Targeted Disruption of Transforming Growth Factor-β Receptor Type II and/or p27 Mice

    Article • Endocrine, January 2001, Springer Science + Business Media

    Masanobu Oshima

  98. Optimization of the helper-dependent adenovirus system for production and potency in vivo

    Article • Proceedings of the National Academy of Sciences, February 2000, Proceedings of the National Academy of Sciences

    Masanobu Oshima

  99. Intestinal polyposis in mice with a dominant stable mutation of the beta -catenin gene

    Article • The EMBO Journal, November 1999, Wiley

    Masanobu Oshima

  100. Impaired extrapyramidal function caused by the targeted disruption of Retinoid X receptor RXRgamma1 isoform

    Article • Genes to Cells, April 1999, Wiley

    Masanobu Oshima

  101. Estrogen-induced tumorigenesis in the pituitary gland of TGF-β(+/−) knockout mice

    Article • Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, July 1998, Elsevier

    Masanobu Oshima

  102. Nuclear translocation of beta-catenin in hereditary and carcinogen- induced intestinal adenomas

    Article • Carcinogenesis, April 1998, Oxford University Press (OUP)

    Masanobu Oshima

  103. Intestinal Tumorigenesis in Compound Mutant Mice of both Dpc4(Smad4) and Apc Genes

    Article • Cell, March 1998, Elsevier

    Masanobu Oshima

  104. Suppression of intestinal polyp development by low-fat and high-fiber diet in Apc(delta716) knockout mice

    Article • Carcinogenesis, October 1997, Oxford University Press (OUP)

    Masanobu Oshima

  105. Early embryonic lethality caused by targeted disruption of the mouse selenocysteine tRNA gene ( Trsp )

    Article • Proceedings of the National Academy of Sciences, May 1997, Proceedings of the National Academy of Sciences

    Masanobu Oshima

  106. Suppression of Intestinal Polyposis in ApcΔ716 Knockout Mice by Inhibition of Cyclooxygenase 2 (COX-2)

    Article • Cell, November 1996, Elsevier

    Masanobu Oshima

  107. TGF-β Receptor Type II Deficiency Results in Defects of Yolk Sac Hematopoiesis and Vasculogenesis

    Article • Developmental Biology, October 1996, Elsevier

    Masanobu Oshima

  108. Early Embryonic Lethality Caused by Targeted Disruption of the Mouse Thioredoxin Gene

    Article • Developmental Biology, August 1996, Elsevier

    Masanobu Oshima

  109. Effects of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine on intestinal polyp development in ApcΔ716 knockout mice

    Article • Molecular Carcinogenesis, January 1996, Wiley

    Masanobu Oshima

  110. Loss of Apc heterozygosity and abnormal tissue building in nascent intestinal polyps in mice carrying a truncated Apc gene.

    Article • Proceedings of the National Academy of Sciences, May 1995, Proceedings of the National Academy of Sciences

    Masanobu Oshima

  111. Effects of docosahexaenoic acid (DHA) on intestinal polyp development in ApcΔ716 knockout mice

    Article • Carcinogenesis, January 1995, Oxford University Press (OUP)

    Masanobu Oshima