All Stories

  1. Iriomoteolide-1a and -1b: Structure Elucidation by Integrating NMR Spectroscopic Analysis, Theoretical Calculation, and Total Synthesis

    Article • Journal of the American Chemical Society, October 2024, American Chemical Society (ACS)

    Prof. Dr. Haruhiko Fuwa

  2. Total Synthesis of (−)-Fasicularin

    Article • The Journal of Organic Chemistry, July 2024, American Chemical Society (ACS)

    Prof. Dr. Haruhiko Fuwa

  3. Total Synthesis of (−)-Enigmazole A by the Macrocyclization/Transannular Pyran Cyclization Strategy

    Article • Organic Letters, February 2024, American Chemical Society (ACS)

    Prof. Dr. Haruhiko Fuwa

  4. Atomic-resolution structure analysis inside an adaptable porous framework

    Article • Nature Communications, January 2024, Springer Science + Business Media

    Prof. Dr. Haruhiko Fuwa

  5. Pursuing Step Economy in Total Synthesis of Complex Marine Macrolide Natural Products

    Article • January 2024, Springer Science + Business Media

    Prof. Dr. Haruhiko Fuwa

  6. Total Synthesis of (−)-Enigmazole B

    Article • Organic Letters, October 2023, American Chemical Society (ACS)

    Prof. Dr. Haruhiko Fuwa

  7. Total Synthesis of Marine Macrolide Natural Products by the Macrocyclization/Transannular Pyran Cyclization Strategy

    Article • Synlett, September 2023, Thieme Publishing Group

    Prof. Dr. Haruhiko Fuwa

  8. Total Synthesis of (+)-Muricatetrocin B via a Late-Stage Co-Catalyzed Hartung–Mukaiyama Cyclization

    Article • Organic Letters, August 2023, American Chemical Society (ACS)

    Prof. Dr. Haruhiko Fuwa

  9. An 11-Step Synthesis of (+)-Neopeltolide by the Macrocyclization/Transannular Pyran Cyclization Strategy

    Article • Bulletin of the Chemical Society of Japan, March 2023, The Chemical Society of Japan

    Prof. Dr. Haruhiko Fuwa

  10. Collective Asymmetric Total Synthesis of Cylindricines

    Article • Organic Letters, March 2023, American Chemical Society (ACS)

    Prof. Dr. Haruhiko Fuwa

  11. Collective Asymmetric Total Synthesis of Cylindricines

    Article • February 2023, American Chemical Society (ACS)

    Prof. Dr. Haruhiko Fuwa

  12. N-Terminal-selective Cu-catalyzed [3+2] cycloaddition for irreversible assembly of two modules with a peptide

    Article • February 2023, American Chemical Society (ACS)

    Prof. Dr. Haruhiko Fuwa

  13. Au-catalyzed stereodivergent synthesis of 2,5-disubstituted pyrrolidines: total synthesis of (+)-monomorine I and (+)-indolizidine 195B

    Article • Chemical Communications, January 2023, Royal Society of Chemistry

    Prof. Dr. Haruhiko Fuwa

  14. GIAO NMR Calculation-driven Stereochemical Assignment of Marine Macrolide Natural Products: Assessment of the Performance of DP4 and DP4+ Analyses and Assignment of the Relative Configuration of Leptolyngbyalide A–C/Oscillariolide Macrolactone

    Article • Bulletin of the Chemical Society of Japan, November 2022, The Chemical Society of Japan

    Prof. Dr. Haruhiko Fuwa

  15. Stereoselective Tandem Synthesis of Pyrrolidine Derivatives under Gold Catalysis: An Asymmetric Synthesis of (−)-Lepadiformine A

    Article • Organic Letters, July 2022, American Chemical Society (ACS)

    Prof. Dr. Haruhiko Fuwa

  16. Total Synthesis of (+)-Neopeltolide by the Macrocyclization/Transannular Pyran Cyclization Strategy

    Article • Organic Letters, June 2022, American Chemical Society (ACS)

    Prof. Dr. Haruhiko Fuwa

  17. Frontispiece: Tandem Macrolactone Synthesis: Total Synthesis of (−)‐Exiguolide by a Macrocyclization/Transannular Pyran Cyclization Strategy

    Article • Angewandte Chemie International Edition, May 2022, Wiley

    Prof. Dr. Haruhiko Fuwa

  18. Frontispiz: Tandem Macrolactone Synthesis: Total Synthesis of (−)‐Exiguolide by a Macrocyclization/Transannular Pyran Cyclization Strategy

    Article • Angewandte Chemie, May 2022, Wiley

    Prof. Dr. Haruhiko Fuwa

  19. Gambierol Blocks a K+ Current Fraction without Affecting Catecholamine Release in Rat Fetal Adrenomedullary Cultured Chromaffin Cells

    Article • Toxins, April 2022, MDPI AG

    Prof. Dr. Haruhiko Fuwa

  20. Tandem Macrolactone Synthesis: Total Synthesis of (−)‐Exiguolide by a Macrocyclization/Transannular Pyran Cyclization Strategy

    Article • Angewandte Chemie, March 2022, Wiley

    Prof. Dr. Haruhiko Fuwa

  21. Tandem Macrolactone Synthesis: Total Synthesis of (−)‐Exiguolide by a Macrocyclization/Transannular Pyran Cyclization Strategy

    Article • Angewandte Chemie International Edition, March 2022, Wiley

    Prof. Dr. Haruhiko Fuwa

  22. Determination of the toxicity equivalency factors for ciguatoxins using human sodium channels

    Article • Food and Chemical Toxicology, February 2022, Elsevier

    Prof. Dr. Haruhiko Fuwa

  23. Total Synthesis of (−)-Exiguolide, a Potent Anticancer Marine Macrolide

    Article • Heterocycles, January 2022, Japan Institute of Heterocyclic Chemistry

    Prof. Dr. Haruhiko Fuwa

  24. Asymmetric Synthesis of (−)-Atorvastatin Calcium by Tandem Catalysis

    Article • Bulletin of the Chemical Society of Japan, August 2021, The Chemical Society of Japan

    Prof. Dr. Haruhiko Fuwa

  25. Synthesis-Driven Stereochemical Assignment of Marine Polycyclic Ether Natural Products

    Article • Marine Drugs, April 2021, MDPI AG

    Prof. Dr. Haruhiko Fuwa

  26. Stereoselective Synthesis of the Southern Hemisphere Acyclic Domain of Neaumycin B

    Article • The Journal of Organic Chemistry, April 2021, American Chemical Society (ACS)

    Prof. Dr. Haruhiko Fuwa

  27. Ruthenium-Catalyzed Intramolecular Double Hydrofunctionalization of Alkynes. Synthesis of Spirocyclic Hemiaminal Ethers and Their Lewis Acid-Mediated Cleavage/Nucleophilic Addition

    Article • The Journal of Organic Chemistry, April 2021, American Chemical Society (ACS)

    Prof. Dr. Haruhiko Fuwa

  28. Cobalt-Catalyzed Hartung–Mukaiyama Cyclization of γ-Hydroxy Olefins: Stereocontrolled Synthesis of the Tetrahydrofuran Moiety of Amphidinolide N

    Article • The Journal of Organic Chemistry, March 2021, American Chemical Society (ACS)

    Prof. Dr. Haruhiko Fuwa

  29. Total synthesis and complete configurational assignment of amphirionin-2

    Article • Chemical Science, January 2021, Royal Society of Chemistry

    Prof. Dr. Haruhiko Fuwa

  30. Structure determination, correction, and disproof of marine macrolide natural products by chemical synthesis

    Article • Organic Chemistry Frontiers, January 2021, Royal Society of Chemistry

    Prof. Dr. Haruhiko Fuwa

  31. Unified Total Synthesis of (−)‐Enigmazole A and (−)‐15‐ O ‐Methylenigmazole A

    Article • Chemistry - An Asian Journal, October 2020, Wiley

    Prof. Dr. Haruhiko Fuwa

  32. Tandem Three‐Component Synthesis of syn ‐1,2‐ and syn ‐1,3‐Diol Derivatives

    Article • Chemistry - An Asian Journal, February 2020, Wiley

    Prof. Dr. Haruhiko Fuwa

  33. Total Synthesis of a Marine Macrolide Natural Product, Iriomoteolide-2a: The Fundamental Role of Total Synthesis in Natural Product Chemistry

    Article • Journal of Synthetic Organic Chemistry Japan, August 2019, The Society of Synthetic Organic Chemistry, Japan

    Prof. Dr. Haruhiko Fuwa

  34. Cover Feature: Total Synthesis, Stereochemical Revision, and Biological Assessment of Iriomoteolide‐2a (Chem. Eur. J. 36/2019)

    Article • Chemistry - A European Journal, May 2019, Wiley

    Prof. Dr. Haruhiko Fuwa

  35. Total Synthesis, Stereochemical Revision, and Biological Assessment of Iriomoteolide‐2a

    Article • Chemistry - A European Journal, May 2019, Wiley

    Prof. Dr. Haruhiko Fuwa

  36. Stereoselective Tandem Synthesis of syn-1,3-Diol Derivatives by Integrating Olefin Cross-Metathesis, Hemiacetalization, and Intramolecular Oxa-Michael Addition

    Article • Organic Letters, May 2019, American Chemical Society (ACS)

    Prof. Dr. Haruhiko Fuwa

  37. Fluorescence-labeled neopeltolide derivatives for subcellular localization imaging

    Article • Organic & Biomolecular Chemistry, January 2019, Royal Society of Chemistry

    Prof. Dr. Haruhiko Fuwa

  38. Ruthenium-Catalyzed Intramolecular Double Hydroalkoxylation of Internal Alkynes

    Article • Organic Letters, December 2018, American Chemical Society (ACS)

    Prof. Dr. Haruhiko Fuwa

  39. Total Synthesis of (−)-Enigmazole A

    Article • Angewandte Chemie, March 2018, Wiley

    Prof. Dr. Haruhiko Fuwa

  40. Total Synthesis of (−)-Enigmazole A

    Article • Angewandte Chemie International Edition, March 2018, Wiley

    Prof. Dr. Haruhiko Fuwa

  41. Total Synthesis and Stereochemical Revision of Iriomoteolide-2a

    Article • Angewandte Chemie, February 2018, Wiley

    Prof. Dr. Haruhiko Fuwa

  42. Total Synthesis and Stereochemical Revision of Iriomoteolide-2a

    Article • Angewandte Chemie International Edition, February 2018, Wiley

    Prof. Dr. Haruhiko Fuwa

  43. A Synthetic Analogue of Neopeltolide, 8,9-Dehydroneopeltolide, Is a Potent Anti-Austerity Agent against Starved Tumor Cells

    Article • Marine Drugs, October 2017, MDPI AG

    Prof. Dr. Haruhiko Fuwa

  44. Tetracyclic Truncated Analogue of the Marine Toxin Gambierol Modifies NMDA, Tau, and Amyloid β Expression in Mice Brains: Implications in AD Pathology

    Article • ACS Chemical Neuroscience, February 2017, American Chemical Society (ACS)

    Prof. Dr. Haruhiko Fuwa

  45. Exploiting Ruthenium Carbene-Catalyzed Reactions in Total Synthesis of Marine Oxacyclic Natural Products

    Article • Bulletin of the Chemical Society of Japan, December 2016, The Chemical Society of Japan

    Prof. Dr. Haruhiko Fuwa

  46. Diastereoselective Ring-Closing Metathesis as a Means to Construct Medium-Sized Cyclic Ethers: Application to the Synthesis of a Photoactivatable Gambierol Derivative

    Article • The Journal of Organic Chemistry, September 2016, American Chemical Society (ACS)

    Prof. Dr. Haruhiko Fuwa

  47. Effect of carbon chain length in acyl coenzyme A on the efficiency of enzymatic transformation of okadaic acid to 7- O -acyl okadaic acid

    Article • Bioorganic & Medicinal Chemistry Letters, July 2016, Elsevier

    Prof. Dr. Haruhiko Fuwa

  48. Total Synthesis and Complete Stereostructure of a Marine Macrolide Glycoside, (−)-Lyngbyaloside B

    Article • Chemistry - A European Journal, April 2016, Wiley

    Prof. Dr. Haruhiko Fuwa

  49. Toward the Total Synthesis of Amphidinolide N: Synthesis of the C8–C29 Fragment

    Article • Organic Letters, April 2016, American Chemical Society (ACS)

    Prof. Dr. Haruhiko Fuwa

  50. Complete Stereochemical Assignment of Campechic Acids A and B

    Article • The Journal of Organic Chemistry, April 2016, American Chemical Society (ACS)

    Prof. Dr. Haruhiko Fuwa

  51. Contemporary Strategies for the Synthesis of Tetrahydropyran Derivatives: Application to Total Synthesis of Neopeltolide, a Marine Macrolide Natural Product

    Article • Marine Drugs, March 2016, MDPI AG

    Prof. Dr. Haruhiko Fuwa

  52. Progress toward the Total Synthesis of Goniodomin A: Stereocontrolled, Convergent Synthesis of the C12–C36 Fragment

    Article • The Journal of Organic Chemistry, January 2016, American Chemical Society (ACS)

    Prof. Dr. Haruhiko Fuwa

  53. Concise synthesis of the C15–C38 fragment of okadaic acid, a specific inhibitor of protein phosphatases 1 and 2A

    Article • Tetrahedron, September 2015, Elsevier

    Prof. Dr. Haruhiko Fuwa

  54. Evaluation of gambierol and its analogs for their inhibition of human Kv1.2 and cytotoxicity

    Article • Bioorganic & Medicinal Chemistry Letters, February 2015, Elsevier

    Prof. Dr. Haruhiko Fuwa

  55. Concise synthesis of the A/BCD-ring fragment of gambieric acid A

    Article • Frontiers in Chemistry, January 2015, Frontiers

    Prof. Dr. Haruhiko Fuwa

  56. Studies toward the Total Synthesis of Amphidinolide N: Stereocontrolled Synthesis of the C13–C29 Segment

    Article • Heterocycles, January 2015, Japan Institute of Heterocyclic Chemistry

    Prof. Dr. Haruhiko Fuwa

  57. Concise Synthesis of the C15–C38 Fragment of Okadaic Acid: Application of the Suzuki–Miyaura Reaction to Spiroacetal Synthesis

    Article • Organic Letters, December 2014, American Chemical Society (ACS)

    Prof. Dr. Haruhiko Fuwa

  58. Programmed Cell Death Induced by (−)-8,9-Dehydroneopeltolide in Human Promyelocytic Leukemia HL-60 Cells under Energy Stress Conditions

    Article • Marine Drugs, November 2014, MDPI AG

    Prof. Dr. Haruhiko Fuwa

  59. Total Synthesis, Stereochemical Reassignment, and Biological Evaluation of (−)-Lyngbyaloside B

    Article • Angewandte Chemie International Edition, November 2014, Wiley

    Prof. Dr. Haruhiko Fuwa

  60. Potassium currents inhibition by gambierol analogs prevents human T lymphocyte activation

    Article • Archives of Toxicology, August 2014, Springer Science + Business Media

    Prof. Dr. Haruhiko Fuwa

  61. Total Synthesis and Complete Structural Assignment of Gambieric Acid A, a Large Polycyclic Ether Marine Natural Product

    Article • The Chemical Record, August 2014, Wiley

    Prof. Dr. Haruhiko Fuwa

  62. Synthesis and biological evaluation of (+)-neopeltolide analogues: Importance of the oxazole-containing side chain

    Article • Bioorganic & Medicinal Chemistry Letters, June 2014, Elsevier

    Prof. Dr. Haruhiko Fuwa

  63. Stereoselective Synthesis of Medium-Sized Cyclic Ethers: Application of C-Glycosylation Chemistry to Seven- to Nine-Membered Lactone-Derived Thioacetals and Their Sulfone Counterparts

    Article • The Journal of Organic Chemistry, February 2014, American Chemical Society (ACS)

    Prof. Dr. Haruhiko Fuwa

  64. Total Synthesis and Structure Revision of Didemnaketal B

    Article • Chemistry - A European Journal, January 2014, Wiley

    Prof. Dr. Haruhiko Fuwa

  65. Synthesis and Biological Evaluation of Aspergillide A/Neopeltolide Chimeras

    Article • Chemistry Letters, September 2013, The Chemical Society of Japan

    Prof. Dr. Haruhiko Fuwa

  66. Total Synthesis of the Proposed Structure of Didemnaketal B

    Article • Organic Letters, July 2013, American Chemical Society (ACS)

    Prof. Dr. Haruhiko Fuwa

  67. Concise Synthesis and Biological Assessment of (+)-Neopeltolide and a 16-Member Stereoisomer Library of 8,9-Dehydroneopeltolide: Identification of Pharmacophoric Elements

    Article • Chemistry - A European Journal, April 2013, Wiley

    Prof. Dr. Haruhiko Fuwa

  68. Total Synthesis and Biological Evaluation of (+)-Gambieric Acid A and Its Analogues

    Article • Chemistry - A European Journal, March 2013, Wiley

    Prof. Dr. Haruhiko Fuwa

  69. Total Synthesis of 13-Demethyllyngbyaloside B

    Article • Organic Letters, March 2013, American Chemical Society (ACS)

    Prof. Dr. Haruhiko Fuwa

  70. Total synthesis and biological evaluation of (−)-exiguolide analogues: importance of the macrocyclic backbone

    Article • Organic & Biomolecular Chemistry, January 2013, Royal Society of Chemistry

    Dr Hiroshi Kubo, Prof. Dr. Haruhiko Fuwa

  71. Stereoselective Synthesis of the C1–C16 Fragment of Goniodomin A

    Article • Bulletin of the Chemical Society of Japan, September 2012, The Chemical Society of Japan

    Prof. Dr. Haruhiko Fuwa

  72. Effect of Gambierol and Its Tetracyclic and Heptacyclic Analogues in Cultured Cerebellar Neurons: A Structure–Activity Relationships Study

    Article • Chemical Research in Toxicology, August 2012, American Chemical Society (ACS)

    Prof. Dr. Haruhiko Fuwa

  73. Total Synthesis and Complete Stereostructure of Gambieric Acid A

    Article • Journal of the American Chemical Society, July 2012, American Chemical Society (ACS)

    Prof. Dr. Haruhiko Fuwa

  74. Design and Synthesis of Skeletal Analogues of Gambierol: Attenuation of Amyloid-β and Tau Pathology with Voltage-Gated Potassium Channel andN-Methyl-d-aspartate Receptor Implications

    Article • Journal of the American Chemical Society, April 2012, American Chemical Society (ACS)

    Prof. Dr. Haruhiko Fuwa

  75. Tandem catalysis in domino olefin cross-metathesis/intramolecular oxa-conjugate cyclization: concise synthesis of 2,6-cis-substituted tetrahydropyran derivatives

    Article • Organic & Biomolecular Chemistry, January 2012, Royal Society of Chemistry

    Prof. Dr. Haruhiko Fuwa

  76. A CONCISE SYNTHESIS OF THE AB-RING FRAGMENT OF (−)-GAMBIEROL

    Article • Heterocycles, January 2012, Japan Institute of Heterocyclic Chemistry

    Prof. Dr. Haruhiko Fuwa

  77. Total Synthesis of Tetrahydropyran-Containing Natural Products Exploiting Intramolecular Oxa-Conjugate Cyclization

    Article • Heterocycles, January 2012, Japan Institute of Heterocyclic Chemistry

    Prof. Dr. Haruhiko Fuwa

  78. Stereoselective Synthesis of 2,6-Cis-Substituted Tetrahydropyrans: Brønsted Acid-Catalyzed Intramolecular Oxa-Conjugate Cyclization of α,β-Unsaturated Ester Surrogates

    Article • The Journal of Organic Chemistry, December 2011, American Chemical Society (ACS)

    Prof. Dr. Haruhiko Fuwa

  79. Total Synthesis of (−)-Brevenal: A Streamlined Strategy for Practical Synthesis of Polycyclic Ethers

    Article • Chemistry - A European Journal, November 2011, Wiley

    Prof. Dr. Haruhiko Fuwa

  80. Studies toward the total synthesis of gambieric acids, potent antifungal polycyclic ethers: convergent synthesis of a fully elaborated GHIJ-ring fragment

    Article • Tetrahedron, September 2011, Elsevier

    Prof. Dr. Haruhiko Fuwa

  81. A new strategy for the synthesis of substituted dihydropyrones and tetrahydropyrones via palladium-catalyzed coupling of thioesters

    Article • Tetrahedron, July 2011, Elsevier

    Prof. Dr. Haruhiko Fuwa

  82. Comparative Cytotoxicity of Gambierol versus Other Marine Neurotoxins

    Article • Chemical Research in Toxicology, June 2011, American Chemical Society (ACS)

    Prof. Dr. Haruhiko Fuwa

  83. Biosynthesis-Inspired Intramolecular Oxa-Conjugate Cyclization of α,β-Unsaturated Thioesters: Stereoselective Synthesis of 2,6-cis-Substituted Tetrahydropyrans

    Article • Organic Letters, April 2011, American Chemical Society (ACS)

    Prof. Dr. Haruhiko Fuwa

  84. A Convergent Synthesis of the C1−C16 Segment of Goniodomin A via Palladium-Catalyzed Organostannane−Thioester Coupling

    Article • Organic Letters, March 2011, American Chemical Society (ACS)

    Prof. Dr. Haruhiko Fuwa

  85. Total Synthesis and Biological Assessment of (−)‐Exiguolide and Analogues

    Article • Chemistry - A European Journal, January 2011, Wiley

    Dr Hiroshi Kubo, Prof. Dr. Haruhiko Fuwa

  86. Suppression of Colon Cancer Metastasis by Aes through Inhibition of Notch Signaling

    Article • Cancer Cell, January 2011, Elsevier

    Masanobu Oshima, Prof. Dr. Haruhiko Fuwa, Dr Hiroki Hashida

  87. Studies toward the total synthesis of gambieric acids: convergent synthesis of the GHIJ-ring fragment having a side chain

    Article • Tetrahedron Letters, January 2011, Elsevier

    Prof. Dr. Haruhiko Fuwa

  88. Synthetic studies on goniodomin A: convergent assembly of the C15–C36 segment via palladium-catalyzed organostannane–thioester coupling

    Article • Tetrahedron, January 2011, Elsevier

    Prof. Dr. Haruhiko Fuwa

  89. Total Synthesis of Structurally Complex Marine Oxacyclic Natural Products

    Article • Bulletin of the Chemical Society of Japan, December 2010, The Chemical Society of Japan

    Prof. Dr. Haruhiko Fuwa

  90. Palladium-Catalyzed Synthesis of N- and O-Heterocycles Starting from Enol Phosphates

    Article • Synlett, December 2010, Thieme Publishing Group

    Prof. Dr. Haruhiko Fuwa

  91. Convergent Assembly of the Spiroacetal Subunit of Didemnaketal B

    Article • Organic Letters, November 2010, American Chemical Society (ACS)

    Prof. Dr. Haruhiko Fuwa

  92. The marine polyether gambierol enhances muscle contraction and blocks a transient K+ current in skeletal muscle cells

    Article • Toxicon, October 2010, Elsevier

    Prof. Dr. Haruhiko Fuwa

  93. An enantioselective total synthesis of aspergillides A and B

    Article • Tetrahedron, September 2010, Elsevier

    Prof. Dr. Haruhiko Fuwa

  94. Studies toward the Total Synthesis of Gambieric Acids: Stereocontrolled Synthesis of a DEFG-Ring Model Compound

    Article • The Journal of Organic Chemistry, August 2010, American Chemical Society (ACS)

    Prof. Dr. Haruhiko Fuwa

  95. A Unified Total Synthesis of Aspergillides A and B

    Article • Organic Letters, April 2010, American Chemical Society (ACS)

    Prof. Dr. Haruhiko Fuwa

  96. Stereoselective Synthesis of Substituted Tetrahydropyrans via Domino Olefin Cross-Metathesis/Intramolecular Oxa-Conjugate Cyclization

    Article • Organic Letters, April 2010, American Chemical Society (ACS)

    Prof. Dr. Haruhiko Fuwa

  97. An Efficient Synthesis of 2,6-Disubstituted 2,3-Dihydro-4H-pyran-4-ones via Sonogashira Coupling of p-Toluenethiol Esters

    Article • Synlett, March 2010, Thieme Publishing Group

    Prof. Dr. Haruhiko Fuwa

  98. A Concise Total Synthesis of (+)-Neopeltolide

    Article • Angewandte Chemie International Edition, March 2010, Wiley

    Prof. Dr. Haruhiko Fuwa

  99. Total Synthesis of (−)-Exiguolide

    Article • Organic Letters, February 2010, American Chemical Society (ACS)

    Prof. Dr. Haruhiko Fuwa

  100. Highly efficient synthesis of medium-sized lactones via oxidative lactonization: concise total synthesis of isolaurepan

    Article • Organic & Biomolecular Chemistry, January 2010, Royal Society of Chemistry

    Prof. Dr. Haruhiko Fuwa

  101. A Concise Total Synthesis of (±)-Centrolobine

    Article • Heterocycles, January 2010, Japan Institute of Heterocyclic Chemistry

    Prof. Dr. Haruhiko Fuwa

  102. Calcium oscillations induced by gambierol in cerebellar granule cells

    Article • Journal of Cellular Biochemistry, January 2010, Wiley

    Prof. Dr. Haruhiko Fuwa

  103. Total Synthesis and Biological Evaluation of (+)-Neopeltolide and Its Analogues

    Article • Chemistry - A European Journal, November 2009, Wiley

    Prof. Dr. Haruhiko Fuwa

  104. Toward the Total Synthesis of Goniodomin A, An Actin-Targeting Marine Polyether Macrolide: Convergent Synthesis of the C15−C36 Segment

    Article • Organic Letters, November 2009, American Chemical Society (ACS)

    Prof. Dr. Haruhiko Fuwa

  105. Stereocontrolled Synthesis of the DEFG-ring Skeleton of Gambieric Acids

    Article • Chemistry Letters, August 2009, The Chemical Society of Japan

    Prof. Dr. Haruhiko Fuwa

  106. Proteomic Analysis Reveals Multiple Patterns of Response in Cells Exposed to a Toxin Mixture

    Article • Chemical Research in Toxicology, June 2009, American Chemical Society (ACS)

    Prof. Dr. Haruhiko Fuwa

  107. Synthetic Studies on Gambieric Acids, Potent Antifungal Polycyclic Ether Natural Products: Reassignment of the Absolute Configuration of the Nonacyclic Polyether Core by NMR Analysis of Model Compounds

    Article • The Journal of Organic Chemistry, June 2009, American Chemical Society (ACS)

    Prof. Dr. Haruhiko Fuwa

  108. Synthesis of 2-Substituted Indoles and Indolines via Suzuki−Miyaura Coupling/5-endo-trigCyclization Strategies

    Article • The Journal of Organic Chemistry, January 2009, American Chemical Society (ACS)

    Prof. Dr. Haruhiko Fuwa

  109. A New Method for the Generation of Indole-2,3-quinodimethanes from Allenamides

    Article • Chemistry Letters, September 2008, The Chemical Society of Japan

    Prof. Dr. Haruhiko Fuwa

  110. Total Synthesis of (+)-Neopeltolide

    Article • Angewandte Chemie International Edition, June 2008, Wiley

    Prof. Dr. Haruhiko Fuwa

  111. An Efficient Strategy for the Synthesis of Endocyclic Enol Ethers and Its Application to the Synthesis of Spiroacetals

    Article • Organic Letters, June 2008, American Chemical Society (ACS)

    Prof. Dr. Haruhiko Fuwa

  112. Stereocontrolled Synthesis of the A/B-Ring Fragment of Gambieric Acid B: Reassignment of the Absolute Configuration of the Polycyclic Ether Region

    Article • Organic Letters, June 2008, American Chemical Society (ACS)

    Prof. Dr. Haruhiko Fuwa

  113. Total Synthesis of (−)-Brevenal: A Concise Synthetic Entry to the Pentacyclic Polyether Core

    Article • Organic Letters, June 2008, American Chemical Society (ACS)

    Prof. Dr. Haruhiko Fuwa

  114. Convergent strategies for the total synthesis of polycyclic ether marine metabolites

    Article • Natural Product Reports, January 2008, Royal Society of Chemistry

    Prof. Dr. Haruhiko Fuwa

  115. Strategies for the Synthesis of 2-Substituted Indoles and Indolines Starting from Acyclic α-Phosphoryloxy Enecarbamates

    Article • Organic Letters, August 2007, American Chemical Society (ACS)

    Prof. Dr. Haruhiko Fuwa

  116. Divergent Synthesis of Multifunctional Molecular Probes To Elucidate the Enzyme Specificity of Dipeptidic γ-Secretase Inhibitors

    Article • ACS Chemical Biology, May 2007, American Chemical Society (ACS)

    Prof. Dr. Haruhiko Fuwa

  117. An efficient method for the synthesis of enol ethers and enecarbamates. Total syntheses of isoindolobenzazepine alkaloids, lennoxamine and chilenine

    Article • Organic & Biomolecular Chemistry, January 2007, Royal Society of Chemistry

    Prof. Dr. Haruhiko Fuwa

  118. A new method for the generation of indole-2,3-quinodimethanes and 2-(N-alkoxycarbonylamino)-1,3-dienes. Intramolecular Heck/Diels–Alder cycloaddition cascade starting from acyclic α-phosphono enecarbamates

    Article • Chemical Communications, January 2007, Royal Society of Chemistry

    Prof. Dr. Haruhiko Fuwa

  119. A strategy for the synthesis of 2,3-disubstituted indoles starting from N-(o-halophenyl)allenamides

    Article • Organic & Biomolecular Chemistry, January 2007, Royal Society of Chemistry

    Prof. Dr. Haruhiko Fuwa

  120. Total Synthesis, Structure Revision, and Absolute Configuration of (−)-Brevenal

    Article • Journal of the American Chemical Society, December 2006, American Chemical Society (ACS)

    Prof. Dr. Haruhiko Fuwa

  121. Synthesis of biotinylated photoaffinity probes based on arylsulfonamide γ-secretase inhibitors

    Article • Bioorganic & Medicinal Chemistry Letters, August 2006, Elsevier

    Prof. Dr. Haruhiko Fuwa

  122. Synthesis of the JK/LM-ring model of prymnesins, potent hemolytic and ichthyotoxic polycyclic ethers isolated from the red tide alga Prymnesium parvum: confirmation of the relative configuration of the K/L-ring juncture

    Article • Tetrahedron Letters, August 2006, Elsevier

    Prof. Dr. Haruhiko Fuwa

  123. Total Synthesis of the Proposed Structure of Brevenal

    Article • Journal of the American Chemical Society, August 2006, American Chemical Society (ACS)

    Prof. Dr. Haruhiko Fuwa

  124. Novel γ-secretase inhibitors discovered by library screening of in-house synthetic natural product intermediates

    Article • Bioorganic & Medicinal Chemistry Letters, July 2006, Elsevier

    Prof. Dr. Haruhiko Fuwa

  125. Effect of Ciguatoxin 3C on Voltage-Gated Na+ and K+ Currents in Mouse Taste Cells

    Article • Chemical Senses, June 2006, Oxford University Press (OUP)

    Prof. Dr. Haruhiko Fuwa

  126. C-terminal Fragment of Presenilin Is the Molecular Target of a Dipeptidic γ-Secretase-specific Inhibitor DAPT (N-[N-(3,5-Difluorophenacetyl)-L-alanyl]-S-phenylglycinet-Butyl Ester)

    Article • Journal of Biological Chemistry, March 2006, American Society for Biochemistry & Molecular Biology (ASBMB)

    Prof. Dr. Haruhiko Fuwa

  127. Synthetic studies on 3-arylquinazolin-4-ones: intramolecular nucleophilic aromatic substitution reaction of 2-carboxamido-3-arylquinazolin-4-ones and its application to the synthesis of secondary aryl amines

    Article • Tetrahedron, April 2005, Elsevier

    Prof. Dr. Haruhiko Fuwa

  128. Inhibition of Voltage-Gated Potassium Currents by Gambierol in Mouse Taste Cells

    Article • Toxicological Sciences, March 2005, Oxford University Press (OUP)

    Prof. Dr. Haruhiko Fuwa

  129. Diverted Total Synthesis and Biological Evaluation of Gambierol Analogues: Elucidation of Crucial Structural Elements for Potent Toxicity

    Article • Chemistry - A European Journal, October 2004, Wiley

    Prof. Dr. Haruhiko Fuwa

  130. Total Synthesis of Polycyclic Ether Natural Products Based on Suzuki-Miyaura Cross-Coupling

    Article • Synlett, August 2004, Thieme Publishing Group

    Prof. Dr. Haruhiko Fuwa

  131. Convergent synthesis of the ABCDE ring fragment of ciguatoxins

    Article • Tetrahedron Letters, June 2004, Elsevier

    Prof. Dr. Haruhiko Fuwa

  132. Synthetic studies on antascomicin A: construction of the C18–C34 fragment

    Article • Tetrahedron, June 2004, Elsevier

    Prof. Dr. Haruhiko Fuwa

  133. Highly efficient synthesis of medium-sized lactams via intramolecular Staudinger–aza-Wittig reaction of ω-azido pentafluorophenyl ester: synthesis and biological evaluation of LY411575 analogues

    Article • Tetrahedron Letters, March 2004, Elsevier

    Prof. Dr. Haruhiko Fuwa

  134. Pathological effects on mice by gambierol, possibly one of the ciguatera toxins

    Article • Toxicon, December 2003, Elsevier

    Prof. Dr. Haruhiko Fuwa

  135. Synthesis and biological evaluation of gambierol analogues

    Article • Bioorganic & Medicinal Chemistry Letters, August 2003, Elsevier

    Prof. Dr. Haruhiko Fuwa

  136. Total Synthesis of (−)-Gambierol

    Article • Journal of the American Chemical Society, December 2002, American Chemical Society (ACS)

    Prof. Dr. Haruhiko Fuwa

  137. Synthetic Studies toward Gambierol. Convergent Synthesis of the Octacyclic Polyether Core

    Article • Organic Letters, November 2001, American Chemical Society (ACS)

    Prof. Dr. Haruhiko Fuwa