All Stories

  1. Discovery of a potent melatonin-based inhibitor of quinone reductase-2 with neuroprotective and neurogenic properties

    Article • European Journal of Medicinal Chemistry, November 2024, Elsevier

    Dr Martin Estrada Valencia

  2. Corrigendum to “An inhibitor of interaction between the transcription factor NRF2 and the E3 ubiquitin ligase adapter β-TrCP delivers anti-inflammatory responses in mouse liver” [Redox Biol. 55 (2022) 102396/PMID: 35839629]

    Article • Redox Biology, September 2022, Elsevier

    Dr Martin Estrada Valencia

  3. Resveratrol-Based MTDLs to Stimulate Defensive and Regenerative Pathways and Block Early Events in Neurodegenerative Cascades

    Article • Journal of Medicinal Chemistry, March 2022, American Chemical Society (ACS)

    Dr Martin Estrada Valencia

  4. Synthesis and Biological Assessment of 4,1-Benzothiazepines with Neuroprotective Activity on the Ca2+ Overload for the Treatment of Neurodegenerative Diseases and Stroke

    Article • Molecules, July 2021, MDPI AG

    Dr Martin Estrada Valencia

  5. Optical control of muscular nicotinic channels with azocuroniums, photoswitchable azobenzenes bearing two N-methyl-N-carbocyclic quaternary ammonium groups

    Article • European Journal of Medicinal Chemistry, August 2020, Elsevier

    Dr Martin Estrada Valencia

  6. Tuning melatonin receptor subtype selectivity in oxadiazolone-based analogues: Discovery of QR2 ligands and NRF2 activators with neurogenic properties

    Article • European Journal of Medicinal Chemistry, March 2020, Elsevier

    Dr Martin Estrada Valencia

  7. Structure-Activity Relationship of Potent Photo-Switchable Neuromuscular Inhibitors

    Article • Biophysical Journal, February 2019, Elsevier

    Dr Martin Estrada Valencia

  8. New flavonoid – N,N-dibenzyl(N-methyl)amine hybrids: Multi-target-directed agents for Alzheimer´s disease endowed with neurogenic properties

    Article • Journal of Enzyme Inhibition and Medicinal Chemistry, January 2019, Taylor & Francis

    Dr. María Isabel Rodríguez-Franco, Dr Jose A Morales-Garcia, Dr Martin Estrada Valencia

  9. Multi-target-directed ligands for Alzheimer's disease: Discovery of chromone-based monoamine oxidase/cholinesterase inhibitors

    Article • European Journal of Medicinal Chemistry, October 2018, Elsevier

    Dr. María Isabel Rodríguez-Franco, Dr Martin Estrada Valencia, Professor Fernanda Borges

  10. Neurogenic and neuroprotective donepezil-flavonoid hybrids with sigma-1 affinity and inhibition of key enzymes in Alzheimer's disease

    Article • European Journal of Medicinal Chemistry, August 2018, Elsevier

    Dr Martin Estrada Valencia

  11. Functional Characterization of Novel Photo-Switchable Neuromuscular Blockers

    Article • Biophysical Journal, February 2018, Elsevier

    Dr Martin Estrada Valencia

  12. New cinnamic – N-benzylpiperidine and cinnamic – N,N-dibenzyl(N-methyl)amine hybrids as Alzheimer-directed multitarget drugs with antioxidant, cholinergic, neuroprotective and neurogenic properties

    Article • European Journal of Medicinal Chemistry, October 2016, Elsevier

    Dr Jose A Morales-Garcia, Dr. María Isabel Rodríguez-Franco, Dr Martin Estrada Valencia

  13. Recent Advances in Neurogenic Small Molecules as Innovative Treatments for Neurodegenerative Diseases

    Article • Molecules, September 2016, MDPI AG

    Dr. María Isabel Rodríguez-Franco, Dr Martin Estrada Valencia

  14. New neurogenic lipoic-based hybrids as innovative Alzheimer's drugs with σ-1 agonism and β-secretase inhibition

    Article • Future Medicinal Chemistry, July 2016, Future Science

    Dr Jose A Morales-Garcia, Dr. María Isabel Rodríguez-Franco, Maurizio Romano, Dr Martin Estrada Valencia

  15. 3-Amidocoumarins as Potential Multifunctional Agents against Neurodegenerative Diseases

    Article • ChemMedChem, October 2015, Wiley

    Dr. María Isabel Rodríguez-Franco, Dr Maria João Matos, Dr Martin Estrada Valencia, Professor Fernanda Borges

  16. Potent and selective MAO-B inhibitory activity: Amino- versus nitro-3-arylcoumarin derivatives

    Article • Bioorganic & Medicinal Chemistry Letters, February 2015, Elsevier

    Dr. María Isabel Rodríguez-Franco, Dr Maria João Matos, Dr Martin Estrada Valencia

  17. Discovery of 5-(4-Hydroxyphenyl)-3-oxo-pentanoic Acid [2-(5-Methoxy-1H-indol-3-yl)-ethyl]-amide as a Neuroprotectant for Alzheimer’s Disease by Hybridization of Curcumin and Melatonin

    Article • ACS Chemical Neuroscience, August 2014, American Chemical Society (ACS)

    Dr. María Isabel Rodríguez-Franco, Dr Martin Estrada Valencia

  18. Assessment of the anticonvulsant activity of pyrazolo[1,5-a][1,3,5]triazines obtained by synthesis

    Article • Revista Colombiana de Ciencias Químico Farmacéuticas, June 2014, Universidad Nacional de Colombia

    Dr Martin Estrada Valencia

  19. Anticonvulsant profile of 2-ethylthio-7-methyl-4-(4-methylphenyl)pyrazolo[1,5-a][1,3,5]triazine

    Article • Brazilian Journal of Pharmaceutical Sciences, March 2014, FapUNIFESP (SciELO)

    Dr Martin Estrada Valencia

  20. PP2A Ligand ITH12246 Protects against Memory Impairment and Focal Cerebral Ischemia in Mice

    Article • ACS Chemical Neuroscience, September 2013, American Chemical Society (ACS)

    Dr. María Isabel Rodríguez-Franco, Dr Martin Estrada Valencia

  21. Pyridonepezils, new dual AChE inhibitors as potential drugs for the treatment of Alzheimer's disease: Synthesis, biological assessment, and molecular modeling

    Article • European Journal of Medicinal Chemistry, November 2012, Elsevier

    Dr. María Isabel Rodríguez-Franco, Dr Martin Estrada Valencia

  22. Regioselective synthesis of novel 4-aryl-2-ethylthio-7-methyl pyrazolo[1,5-a]-[1,3,5]-triazines

    Article • Tetrahedron Letters, July 2006, Elsevier

    Dr Martin Estrada Valencia

  23. Isolated molecules in 2-ethylsulfanyl-7-methyl-4-(4-methylphenyl)pyrazolo[1,5-a][1,3,5]triazine and hydrogen-bonded sheets ofR22(10),R22(16),R44(22) andR...

    Article • Acta Crystallographica Section C Crystal Structure Communications, February 2006, International Union of Crystallography

    Dr John N Low, Dr Martin Estrada Valencia

  24. S-EthylN-benzoyldithiocarbamate: two independent hydrogen-bondedR_{\bf 2}^{\bf 2}(8) dimers of different symmetry linked into chains by a C—H...π(arene) interaction

    Article • Acta Crystallographica Section C Crystal Structure Communications, June 2004, International Union of Crystallography

    Dr John N Low, Dr Martin Estrada Valencia