All Stories

  1. Synthesis, Cytotoxicity Evaluation, and Computational Insights of Novel 1,4-Diazepane-Based Sigma Ligands

    Article • ACS Medicinal Chemistry Letters, December 2019, American Chemical Society (ACS)

    Maurizio Romano

  2. Dysregulation of TDP‐43 intracellular localization and early onset ALS are associated with a TARDBP S375G variant

    Article • Brain Pathology, December 2018, Wiley

    Maurizio Romano

  3. New piperidine-based derivatives as sigma receptor ligands. Synthesis and pharmacological evaluation

    Article • Bioorganic & Medicinal Chemistry Letters, October 2018, Elsevier

    Maurizio Romano

  4. Systematic Analysis of Gene Expression Profiles Controlled by hnRNP Q and hnRNP R, Two Closely Related Human RNA Binding Proteins Implicated in mRNA Processing Mechanisms

    Article • Frontiers in Molecular Biosciences, August 2018, Frontiers

    Maurizio Romano

  5. RhoGAPp190: A potential player in tbph-mediated neurodegeneration in Drosophila

    Article • PLoS ONE, April 2018, PLOS

    Maurizio Romano

  6. Essential role of hippocampal noradrenaline in the regulation of spatial working memory and TDP-43 tissue pathology

    Article • The Journal of Comparative Neurology, February 2018, Wiley

    Maurizio Romano

  7. Role of the Long Non-Coding RNA Growth Arrest-Specific 5 in Glucocorticoid Response in Children with Inflammatory Bowel Disease

    Article • Basic & Clinical Pharmacology & Toxicology, August 2017, Wiley

    Professor Giuliana Decorti, Maurizio Romano

  8. Major hnRNP proteins act as general TDP-43 functional modifiers both in Drosophila and human neuronal cells

    Article • Nucleic Acids Research, May 2017, Oxford University Press (OUP)

    Maurizio Romano

  9. Keratin14 mRNA expression in human pneumocytes during quiescence, repair and disease

    Article • PLoS ONE, February 2017, PLOS

    Maurizio Romano

  10. Computer-assisted design, synthesis, binding and cytotoxicity assessments of new 1-(4-(aryl(methyl)amino)butyl)-heterocyclic sigma 1 ligands

    Article • European Journal of Medicinal Chemistry, October 2016, Elsevier

    Maurizio Romano

  11. TBPH/TDP-43 modulates translation of Drosophila futsch mRNA through an UG-rich sequence within its 5′UTR

    Article • Brain Research, September 2016, Elsevier

    Maurizio Romano

  12. New neurogenic lipoic-based hybrids as innovative Alzheimer's drugs with σ-1 agonism and β-secretase inhibition

    Article • Future Medicinal Chemistry, July 2016, Future Science

    Dr Jose A Morales-Garcia, Dr. María Isabel Rodríguez-Franco, Maurizio Romano, Dr Martin Estrada Valencia

  13. Antimycobacterial activity of new N 1 -[1-[1-aryl-3-[4-(1 H -imidazol-1-yl)phenyl]-3-oxo]propyl]-pyridine-2-carboxamidrazone derivatives

    Article • Bioorganic & Medicinal Chemistry Letters, July 2016, Elsevier

    Maurizio Romano

  14. A novelDrosophilamodel of TDP-43 proteinopathies: N-terminal sequences combined with the Q/N domain induce protein functional loss and locomotion defects

    Article • Disease Models & Mechanisms, April 2016, The Company of Biologists

    Maurizio Romano

  15. Exome sequencing of a colorectal cancer family reveals shared mutation pattern and predisposition circuitry along tumor pathways

    Article • Frontiers in Genetics, September 2015, Frontiers

    Khalid Alfarouk, Maurizio Romano

  16. TDP-43 affects splicing profiles and isoform production of genes involved in the apoptotic and mitotic cellular pathways

    Article • Nucleic Acids Research, August 2015, Oxford University Press (OUP)

    Maurizio Romano

  17. Knockdown of MVK does not lead to changes in NALP3 expression or activation

    Article • Journal of Inflammation, January 2015, Springer Science + Business Media

    Dr Fulvio Celsi, Maurizio Romano

  18. A novel anti-aldolase C antibody specifically interacts with residues 85–102 of the protein

    Article • mAbs, February 2014, Taylor & Francis

    Maurizio Romano

  19. Evolutionarily Conserved Heterogeneous Nuclear Ribonucleoprotein (hnRNP) A/B Proteins Functionally Interact with Human and Drosophila TAR DNA-binding Protein 43 (TDP-43)

    Article • Journal of Biological Chemistry, February 2014, American Society for Biochemistry & Molecular Biology (ASBMB)

    Maurizio Romano

  20. Targeting RNA Binding Proteins Involved in Neurodegeneration

    Article • October 2013, SAGE Publications

    Maurizio Romano

  21. TDP-43 high throughput screening analyses in neurodegeneration: Advantages and pitfalls

    Article • Molecular and Cellular Neuroscience, September 2013, Elsevier

    Maurizio Romano

  22. Role of Pseudoexons and Pseudointrons in Human Cancer

    Article • International Journal of Cell Biology, January 2013, Hindawi Publishing Corporation

    Maurizio Romano

  23. Tirasemtiv (CK-2017357)

    Article • Drugs of the Future, January 2013, Prous Science

    Maurizio Romano

  24. Florbetapir F 18 for brain imaging of beta-amyloid plaques

    Article • Drugs of Today, January 2013, Thomson Reuters (Scientific) Inc. & Affiliates

    Maurizio Romano

  25. Small Cytoplasmic Ribonucleoproteins

    Article • January 2013, Elsevier

    Maurizio Romano

  26. Splicing in the RNA World

    Article • February 2012, Wiley

    Maurizio Romano

  27. Drosophila Answers to TDP-43 Proteinopathies

    Article • Journal of Amino Acids, January 2012, Hindawi Publishing Corporation

    Maurizio Romano

  28. TDP-43 Regulates Drosophila Neuromuscular Junctions Growth by Modulating Futsch/MAP1B Levels and Synaptic Microtubules Organization

    Article • PLoS ONE, March 2011, PLOS

    Maurizio Romano

  29. TDP-43 regulates its mRNA levels through a negative feedback loop

    Article • The EMBO Journal, December 2010, Wiley

    Maurizio Romano

  30. G runs in Cystathionine β-Synthase c.833C/c.844_845ins68 mRNA are splicing silencers of pathogenic 3′ splice sites

    Article • Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, August 2010, Elsevier

    Maurizio Romano

  31. Neuropeptides in saliva of subjects with burning mouth syndrome: a pilot study

    Article • Oral Diseases, May 2010, Wiley

    Maurizio Romano

  32. Nuclear factor TDP-43 can affect selected microRNA levels

    Article • FEBS Journal, April 2010, Wiley

    Maurizio Romano

  33. Functional mapping of the interaction between TDP-43 and hnRNP A2 in vivo

    Article • Nucleic Acids Research, May 2009, Oxford University Press (OUP)

    Maurizio Romano

  34. Dissecting the splicing mechanism of the Drosophila editing enzyme; dADAR

    Article • Nucleic Acids Research, January 2009, Oxford University Press (OUP)

    Maurizio Romano

  35. Thrombopoietin and its splicing variants: Structure and functions in thrombopoiesis and beyond

    Article • Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, July 2008, Elsevier

    Maurizio Romano

  36. Origin and evolution of the c.844_845ins68/c.833T>C mutations within the cystathionine β-synthase gene in great apes

    Article • FEBS Letters, January 2008, Wiley

    Maurizio Romano

  37. Aberrant 5′ splice sites in human disease genes: mutation pattern, nucleotide structure and comparison of computational tools that predict their utilization

    Article • Nucleic Acids Research, June 2007, Oxford University Press (OUP)

    Maurizio Romano

  38. Complex splicing control of the human Thrombopoietin gene by intronic G runs

    Article • Nucleic Acids Research, December 2006, Oxford University Press (OUP)

    Maurizio Romano

  39. Photodynamic Therapy of Subfoveal Choroidal Neovascularization Secondary to Reticular Pattern Dystrophy: Three-Year Results of an Uncontrolled, Prospective Case Series

    Article • American Journal of Ophthalmology, June 2006, Elsevier

    Maurizio Romano

  40. Depletion of TDP 43 overrides the need for exonic and intronic splicing enhancers in the human apoA-II gene

    Article • Nucleic Acids Research, October 2005, Oxford University Press (OUP)

    Maurizio Romano

  41. Human, Drosophila, and C.elegans TDP43: Nucleic Acid Binding Properties and Splicing Regulatory Function

    Article • Journal of Molecular Biology, May 2005, Elsevier

    Maurizio Romano

  42. Corrigendum

    Article • Clinical Genetics, August 2004, Wiley

    Maurizio Romano

  43. hnRNP H binding at the 5' splice site correlates with the pathological effect of two intronic mutations in the NF-1 and TSH  genes

    Article • Nucleic Acids Research, August 2004, Oxford University Press (OUP)

    Maurizio Romano

  44. An Exonic Splicing Enhancer Offsets the Atypical GU-rich 3′ Splice Site of Human Apolipoprotein A-II Exon 3

    Article • Journal of Biological Chemistry, July 2004, American Society for Biochemistry & Molecular Biology (ASBMB)

    Maurizio Romano

  45. Genetic characterization of myeloperoxidase deficiency in Italy

    Article • Human Mutation, January 2004, Wiley

    Maurizio Romano

  46. Identification and Subcellular Localization of Neuronal Calcium Sensor-1 (NCS-1) in Human Neutrophils and HL-60 Cells

    Article • Inflammation, December 2003, Springer Science + Business Media

    Maurizio Romano

  47. Genetic heterogeneity in Malattia Leventinese

    Article • Clinical Genetics, November 2002, Wiley

    Maurizio Romano

  48. Regulation of 3′ Splice Site Selection in the 844ins68 Polymorphism of the Cystathionine β-Synthase Gene

    Article • Journal of Biological Chemistry, September 2002, American Society for Biochemistry & Molecular Biology (ASBMB)

    Maurizio Romano

  49. Article • Journal of Inherited Metabolic Disease, January 2002, Wiley

    Maurizio Romano

  50. Minor Role for BRCA2 (Exon11) and p53 (Exon 5–9) Among Sudanese Breast Cancer Patients

    Article • Breast Cancer Research and Treatment, January 2002, Springer Science + Business Media

    Maurizio Romano

  51. Nuclear factor TDP-43 and SR proteins promote in vitro and in vivo CFTR exon 9 skipping

    Article • The EMBO Journal, April 2001, Wiley

    Maurizio Romano

  52. Expression and characterization of recombinant human eosinophil peroxidase

    Article • European Journal of Biochemistry, June 2000, Wiley

    Maurizio Romano

  53. Functional Characterization of the Novel Mutation IVS 8 (−11delC) (−14T>A) in the Intron 8 of the Glucocerebrosidase Gene of Two Italian Siblings with Gaucher Disease Type I

    Article • Blood Cells Molecules and Diseases, June 2000, Elsevier

    Maurizio Romano

  54. Splicing Factors Induce Cystic Fibrosis Transmembrane Regulator Exon 9 Skipping through a Nonevolutionary Conserved Intronic Element

    Article • Journal of Biological Chemistry, April 2000, American Society for Biochemistry & Molecular Biology (ASBMB)

    Maurizio Romano

  55. The A/G polymorphism in the −78 position of the apolipoprotein A-I promoter does not have a direct effect on transcriptional efficiency

    Article • Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, May 1998, Elsevier

    Maurizio Romano

  56. Hereditary eosinophil peroxidase deficiency: immunochemical and spectroscopic studies and evidence for a compound heterozygosity of the defect.

    Article • Proceedings of the National Academy of Sciences, December 1994, Proceedings of the National Academy of Sciences

    Maurizio Romano

  57. cDNA clones of myeloperoxidase (MPO) and eosinophil peroxidase (EPO) from human blood mononuclear cells differentiated into granulocyte precursors in liquid cultures

    Article • Journal of Immunological Methods, October 1992, Elsevier

    Maurizio Romano