All Stories

  1. Sulfonamide a Valid Scaffold for Antioxidant Drug Development
  2. Computer-aided Design of Coumarins for Neurodegenerative Diseases: Trends of the Last Decade
  3. Chemistry and Pharmacology of Modulators of Oxidative Stress
  4. Structure-Based Optimization of Coumarin hA3 Adenosine Receptor Antagonists
  5. Insights into the Discovery of Novel Neuroprotective Agents: A Comparative Study between Sulfanylcinnamic Acid Derivatives and Related Phenolic Analogues
  6. Optimizing the Synthetic Route of Chromone-2-carboxylic Acids: A Step forward to Speed-Up the Discovery of Chromone-Based Multitarget-Directed Ligands
  7. The chemistry toolbox of multitarget-directed ligands for Alzheimer's disease
  8. Biocide Potentiation Using Cinnamic Phytochemicals and Derivatives
  9. Dietary Polyphenols and Mitochondrial Function: Role in Health and Disease
  10. CompScore: Boosting Structure-Based Virtual Screening Performance by Incorporating Docking Scoring Function Components into Consensus Scoring
  11. Ensemble-Based Modeling of Chemical Compounds with Antimalarial Activity
  12. Boosting Drug Discovery for Parkinson’s: Enhancement of the Delivery of a Monoamine Oxidase-B Inhibitor by Brain-Targeted PEGylated Polycaprolactone-Based Nanoparticles
  13. Evaluation of cinnamaldehyde and cinnamic acid derivatives in microbial growth control
  14. Benzoic acid-derived nitrones: A new class of potential acetylcholinesterase inhibitors and neuroprotective agents
  15. Using microfluidic platforms to develop CNS-targeted polymeric nanoparticles for HIV therapy
  16. Development of piperic acid-based monoamine oxidase inhibitors: Synthesis, structural characterization and biological evaluation
  17. Repurposing nitrocatechols: 5-Nitro-α-cyanocarboxamide derivatives of caffeic acid and caffeic acid phenethyl ester effectively inhibit aggregation of tau-derived hexapeptide AcPHF6
  18. Fine-tuning the neuroprotective and blood-brain barrier permeability profile of multi-target agents designed to prevent progressive mitochondrial dysfunction
  19. Repurposing ibuprofen to control Staphylococcus aureus biofilms
  20. Electrochemical sensing of the thyroid hormone thyronamine (T0AM) via molecular imprinted polymers (MIPs)
  21. Pharmacodynamic evaluation of novel Catechol-O-methyltransferase inhibitors
  22. Bioisosteric OH- to SH-replacement changes the antioxidant profile of ferulic acid
  23. Searching for new cytotoxic agents based on chromen-4-one and chromane-2,4-dione scaffolds
  24. Modulation of ERK1/2 and Akt Pathways Involved in the Neurotrophic Action of Caffeic Acid Alkyl Esters
  25. PEGylated PLGA Nanoparticles As a Smart Carrier to Increase the Cellular Uptake of a Coumarin-Based Monoamine Oxidase B Inhibitor
  26. Computer-aided Drug Discovery Methodologies in the Modeling of Dual Target Ligands as Potential Parkinson’s Disease Therapeutics
  27. Multi-target-directed ligands for Alzheimer's disease: Discovery of chromone-based monoamine oxidase/cholinesterase inhibitors
  28. Desrisking the Cytotoxicity of a Mitochondriotropic Antioxidant Based on Caffeic Acid by a PEGylated Strategy
  29. Microencapsulation of caffeic acid phenethyl ester and caffeic acid phenethyl amide by inclusion in hydroxypropyl-β-cyclodextrin
  30. Electrochemical Behavior of a Mitochondria-Targeted Antioxidant at an Interface between Two Immiscible Electrolyte Solutions: An Alternative Approach to Study Lipophilicity
  31. Correction to Discovery of New Chemical Entities for Old Targets: Insights on the Lead Optimization of Chromone-Based Monoamine Oxidase B (MAO-B) Inhibitors
  32. Hydroxybenzoic Acid Derivatives as Dual-Target Ligands: Mitochondriotropic Antioxidants and Cholinesterase Inhibitors
  33. The Mu.Ta.Lig. Chemotheca: A Community-Populated Molecular Database for Multi-Target Ligands Identification and Compound-Repurposing
  34. Tight-Binding Inhibition of Human Monoamine Oxidase B by Chromone Analogs: A Kinetic, Crystallographic, and Biological Analysis
  35. Development of a PEGylated-Based Platform for Efficient Delivery of Dietary Antioxidants Across the Blood–Brain Barrier
  36. Mitochondria: Targeting mitochondrial reactive oxygen species with mitochondriotropic polyphenolic-based antioxidants
  37. A desirability-based multi objective approach for the virtual screening discovery of broad-spectrum anti-gastric cancer agents
  38. Discovery of a new mitochondria permeability transition pore (mPTP) inhibitor based on gallic acid
  39. Disruption of mitochondrial function as mechanism for anti-cancer activity of a novel mitochondriotropic menadione derivative
  40. Structural elucidation of a series of benzamide derivatives
  41. Fusing Docking Scoring Functions Improves the Virtual Screening Performance for Discovering Parkinson's Disease Dual Target Ligands
  42. Chemoinformatics Profiling of the Chromone Nucleus as a MAO-B/A2AAR Dual Binding Scaffold
  43. NO and HNO donors, nitrones, and nitroxides: Past, present, and future
  44. From flamingo dance to (desirable) drug discovery: a nature-inspired approach
  45. Synthesis and structure-activity relationship study of novel 3-heteroarylcoumarins based on pyridazine scaffold as selective MAO-B inhibitors
  46. Coumarins and adenosine receptors: New perceptions in structure-affinity relationships
  47. Coumarin versus Chromone Monoamine Oxidase B Inhibitors: Quo Vadis?
  48. Development of a Mitochondriotropic Antioxidant Based on Caffeic Acid: Proof of Concept on Cellular and Mitochondrial Oxidative Stress Models
  49. Consensus strategy in genes prioritization and combined bioinformatics analysis for preeclampsia pathogenesis
  50. Long Chain Alkyl Esters of Hydroxycinnamic Acids as Promising Anticancer Agents: Selective Induction of Apoptosis in Cancer Cells
  51. Development of hydroxybenzoic-based platforms as a solution to deliver dietary antioxidants to mitochondria
  52. Polymorphism in the structure of N-(5-methylthiazol-2-yl)-4-oxo-4H-chromene-3-carboxamide
  53. Structure of 7-hydroxy-3-(2-methoxyphenyl)-2-trifluoromethyl-4H-chromen-4-one
  54. Systemic QSAR and phenotypic virtual screening: chasing butterflies in drug discovery
  55. Chromone as a Privileged Scaffold in Drug Discovery: Recent Advances
  56. Derivatives of caffeic acid, a natural antioxidant, as the basis for the discovery of novel nonpeptidic neurotrophic agents
  57. New insights into highly potent tyrosinase inhibitors based on 3-heteroarylcoumarins: Anti-melanogenesis and antioxidant activities, and computational molecular modeling studies
  58. Furvina inhibits the 3-oxo-C12-HSL-based quorum sensing system of Pseudomonas aeruginosa and QS-dependent phenotypes
  59. Heterocyclic Antioxidants in Nature: Coumarins
  60. MAO inhibitory activity of bromo-2-phenylbenzofurans: synthesis, in vitro study, and docking calculations
  61. Molecular Encapsulation of Herbicide Terbuthylazine in Native and Modifiedβ-Cyclodextrin
  62. β–Cyclodextrin carbon nanotube-enhanced sensor for ciprofloxacin detection
  63. Computational Drug Target Screening through Protein Interaction Profiles
  64. Structural elucidation of a series of 6-methyl-3-carboxamidocoumarins
  65. Probing the Hypothesis of SAR Continuity Restoration by the Removal of Activity Cliffs Generators in QSAR
  66. Evaluation of Antioxidant and Antitrypanosomal Properties of a Selected Series of Synthetic 3-Carboxamidocoumarins
  67. Discovery of neurotrophic agents based on hydroxycinnamic acid scaffold
  68. In vitro cellular and mitochondrial toxicity of tolcapone and related nitrocatechols
  69. Phytochemical profiling as a solution to palliate disinfectant limitations
  70. Development of Blood–Brain Barrier Permeable Nitrocatechol-Based Catechol O-Methyltransferase Inhibitors with Reduced Potential for Hepatotoxicity
  71. Study on the volatility of halogenated fluorenes
  72. 6-Methyl-2-oxo-N-(quinolin-6-yl)-2H-chromene-3-carboxamide: crystal structure and Hirshfeld surface analysis
  73. New Perspectives on the Use of Phytochemicals as an Emergent Strategy to Control Bacterial Infections Including Biofilms
  74. Synthesis of 6-aryl/heteroaryl-4-oxo-4H-chromene-2-carboxylic ethyl ester derivatives
  75. Carbon nanotube β-cyclodextrin-modified electrode for quantification of cocaine in seized street samples
  76. Crystal structures of three 6-substituted coumarin-3-carboxamide derivatives
  77. Discovery of New Chemical Entities for Old Targets: Insights on the Lead Optimization of Chromone-Based Monoamine Oxidase B (MAO-B) Inhibitors
  78. Ligand-Based Virtual Screening Using Tailored Ensembles: A Prioritization Tool for Dual A2A Adenosine Receptor Antagonists / Monoamine Oxidase B Inhibitors
  79. Tailoring Lipid and Polymeric Nanoparticles as siRNA Carriers towards the Blood-Brain Barrier – from Targeting to Safe Administration
  80. Long-Term Treatment with Low Doses of Methamphetamine Promotes Neuronal Differentiation and Strengthens Long-Term Potentiation of Glutamatergic Synapses onto Dentate Granule Neurons
  81. Crystal structures of three 3,4,5-trimethoxybenzamide-based derivatives
  82. Efficient and biologically relevant consensus strategy for Parkinson’s disease gene prioritization
  83. Crystal structures of five 6-mercaptopurine derivatives
  84. Carbon nanotube β-cyclodextrin modified electrode as enhanced sensing platform for the determination of fungicide pyrimethanil
  85. Crystal structures of ethyl 6-(4-methylphenyl)-4-oxo-4H-chromene-2-carboxylate and ethyl 6-(4-fluorophenyl)-4-oxo-4H-chromene-2-carboxylate
  86. Exploring coumarin potentialities: development of new enzymatic inhibitors based on the 6-methyl-3-carboxamidocoumarin scaffold
  87. Progress in the development of small molecules as new human A3 adenosine receptor ligands based on the 3-thiophenylcoumarin core
  88. Co-cultivation of Synechocystis salina and Pseudokirchneriella subcapitata under varying phosphorus concentrations evidences an allelopathic competition scenario
  89. Discovery of the first A1 adenosine receptor ligand based on the chromone scaffold
  90. Lessons from black pepper: piperine and derivatives thereof
  91. Design, synthesis and antibacterial study of new potent and selective coumarin–chalcone derivatives for the treatment of tenacibaculosis
  92. 3-Amidocoumarins as Potential Multifunctional Agents against Neurodegenerative Diseases
  93. A comparison of the structures of some 2- and 3-substituted chromone derivatives: a structural study on the importance of the secondary carboxamide backbone for the inhibitory activity of MAO-B
  94. Unravelling the relationship between protein sequence and low-complexity regions entropies: Interactome implications
  95. Harmonization of QSAR Best Practices and Molecular Docking Provides an Efficient Virtual Screening Tool for Discovering New G-Quadruplex Ligands
  96. Plant derived and dietary phenolic antioxidants: Anticancer properties
  97. Development of novel adenosine receptor ligands based on the 3-amidocoumarin scaffold
  98. Topological sub-structural molecular design (TOPS-MODE): a useful tool to explore key fragments of human $$\mathbf{A}_{3}$$ A 3 adenosine receptor ligands
  99. Crystal structures of two 6-(2-hydroxybenzoyl)-5H-thiazolo[3,2-a]pyrimidin-5-ones
  100. Bioactive Coumarins from Marine Sources: Origin, Structural Features and Pharmacological Properties
  101. Synthesis and characterisation of new 4-oxo-N-(substituted-thiazol-2-yl)-4H-chromene-2-carboxamides as potential adenosine receptor ligands
  102. New insights in the discovery of novelh-MAO-B inhibitors: structural characterization of a series ofN-phenyl-4-oxo-4H-chromene-3-carboxamide derivatives
  103. Editorial (Thematic Issue: Oxidative Stress as a Pharmacological Target for Medicinal Chemistry: Synthesis and Evaluation of Compounds with Redox Activity - Part 4)
  104. Interest of Antioxidant Agents in Parasitic Diseases. The Case Study of Coumarins
  105. Microwave-Assisted Synthesis of 5-Phenyl-2-hydroxyacetophenone Derivatives by a Green Suzuki Coupling Reaction
  106. Oxidative Stress and Neurodegenerative Diseases: Looking for a Therapeutic Solution Inspired on Benzopyran Chemistry
  107. Editorial (Thematic Issue: Oxidative Stress as a Pharmacological Target for Medicinal Chemistry: Synthesis and Evaluation of Compounds with Redox Activity - Part 3)
  108. Study of Coumarin-Resveratrol Hybrids as Potent Antioxidant Compounds
  109. A comparative synthesis of 6-benzyl-2,3-dihydroimidazo[2,1-a]phthalazine and 2H-7-benzyl-3,4-dihydropyrimido[2,1-a]phthalazine
  110. Editorial (Thematic Issue: Oxidative Stress as a Pharmacological Target for Medicinal Chemistry: Synthesis and Evaluation of Compounds with Redox Activity - Part 2)
  111. The crystal structures of fourN-(4-halophenyl)-4-oxo-4H-chromene-3-carboxamides
  112. Discovery of two new classes of potent monoamine oxidase-B inhibitors by tricky chemistry
  113. Biology-oriented development of novel lipophilic antioxidants with neuroprotective activity
  114. Exploring cinnamic acid scaffold: development of promising neuroprotective lipophilic antioxidants
  115. Caffeic and Ferulic Acid Derivatives
  116. Bridging the Gap Between Nature and Antioxidant Setbacks: Delivering Caffeic Acid to Mitochondria
  117. Fine-tuning of the hydrophobicity of caffeic acid: studies on the antimicrobial activity against Staphylococcus aureus and Escherichia coli
  118. Hydroxycinnamic acid as a novel scaffold for the development of cyclooxygenase-2 inhibitors
  119. Navigating in chromone chemical space: discovery of novel and distinct A3adenosine receptor ligands
  120. Design and discovery of tyrosinase inhibitors based on a coumarin scaffold
  121. Editorial (Thematic Issue: Oxidative Stress as a Pharmacological Target for Medicinal Chemistry: Synthesis and Evaluation of Compounds with Redox Activity - Part 1)
  122. Nanotechnology and Antioxidant Therapy: An Emerging Approach for Neurodegenerative Diseases
  123. Structural Modifications on Natural-based Products: Synthetic Strategies and Biological Applications
  124. Electrochemical sensor for simultaneous determination of herbicide MCPA and its metabolite 4-chloro-2-methylphenol. Application to photodegradation environmental monitoring
  125. New insights into the antioxidant activity of hydroxycinnamic and hydroxybenzoic systems: Spectroscopic, electrochemistry, and cellular studies
  126. Caffeic acid derivatives, analogs and applications: a patent review (2009 – 2013)
  127. Back Cover: Insight into the Interactions between Novel Coumarin Derivatives and Human A3 Adenosine Receptors (ChemMedChem 10/2014)
  128. Development of neuroprotective antioxidants: In vitro and cellular activity of lipophilic cinnamic acid derivatives
  129. Methamphetamine decreases dentate gyrus stem cell self-renewal and shifts the differentiation towards neuronal fate
  130. Activity cliffs in drug discovery: Dr Jekyll or Mr Hyde?
  131. Insight into the Interactions between Novel Coumarin Derivatives and Human A3 Adenosine Receptors
  132. Alzheimer's disease, enzyme targets and drug discovery struggles: From natural products to drug prototypes
  133. Synthesis, pharmacological study and docking calculations of new benzo[f]coumarin derivatives as dual inhibitors of enzymatic systems involved in neurodegenerative diseases
  134. Microencapsulation of herbicide MCPA with native β-cyclodextrin and its methyl and hydroxypropyl derivatives: An experimental and theoretical investigation
  135. Chromone: A Valid Scaffold in Medicinal Chemistry
  136. Synthesis, spectroscopic characterization and X-ray structure of novel 7-methoxy-4-oxo-N-phenyl-4H-chromene-2-carboxamides
  137. Effects of Chlorophenoxy Herbicides and Their Main Transformation Products on DNA Damage and Acetylcholinesterase Activity
  138. Influence of Hydroxypropyl-β-Cyclodextrin on the Photostability of Fungicide Pyrimethanil
  139. Classifier Ensemble Based on Feature Selection and Diversity Measures for Predicting the Affinity of A 2B Adenosine Receptor Antagonists
  140. Wine and grape polyphenols — A chemical perspective
  141. Wine and grape polyphenols — A chemical perspective [Food Research International 44 (2011) 3134-3148]
  142. Topological structural alerts modulations of mammalian cell mutagenicity for halogenated derivatives
  143. 4-Oxo-N-phenyl-4H-chromene-2-carboxamide and of a new polymorph of 7-methoxy-4-oxo-N-p-tolyl-4H-chromene-2-carboxamide and its hemihydrate
  144. Editorial (Thematic Issue: Synthesis, Evaluation and Pharmacological Applications of Antioxidants- Part 1)
  145. Editorial (Thematic Issue: Synthesis, Evaluation and Pharmacological Applications of Antioxidants- Part 2)
  146. Antioxidant Properties of Hydroxycinnamic Acids: A Review of Structure- Activity Relationships
  147. Synthesis and Study of a Selected Series of Amides with the Coumarin Scaffold for the Treatment of Alzheimer's Disease
  148. Synthesis, crystal structure and spectral properties of 6-bromo-N-(cyclohex-1-en-1-ylmethyl)-4-oxo-4H-chromene-2-carboxamide
  149. Electrochemical Determination of the Herbicide Bentazone Using a Carbon Nanotube β-Cyclodextrin Modified Electrode
  150. Antioxidant therapy: Still in search of the ‘magic bullet’
  151. Synthesis and adenosine receptors binding affinities of a series of 3-arylcoumarins
  152. QSAR and Complex Network Recognition of miRNAs in Stem Cells
  153. Two polymorphs ofN-(2-methoxyphenyl)-4-oxo-4H-chromone-3-carboxamide
  154. Remarkable antioxidant properties of a series of hydroxy-3-arylcoumarins
  155. Alzheimer’s Disease and Antioxidant Therapy: How Long How Far?
  156. Structural characterization of someN-phenyl-4-oxo-4H-2-chromone carboxamides
  157. ChemInform Abstract: Alzheimer′s Disease, Cholesterol, and Statins: The Junctions of Important Metabolic Pathways
  158. Recent Advances on QSAR-Based Profiling of Agonist and Antagonist A3 Adenosine Receptor Ligands
  159. Exploring nature profits: Development of novel and potent lipophilic antioxidants based on galloyl–cinnamic hybrids
  160. ChemInform Abstract: Improved Synthesis of 3‐(Aminoaryl)coumarins.
  161. Synthesis and NMR studies of novel chromone-2-carboxamide derivatives
  162. Parkinson's Disease Management. Part II- Discovery of MAO-B Inhibitors Based on Nitrogen Heterocycles and Analogues
  163. Desirability-based Multi-criteria Virtual Screening of Selective Antimicrobial Cyclic β-Hairpin Cationic Peptidomimetics
  164. Editorial (Hot Topic: Electrochemistry and Antioxidants)
  165. Chalcone-based derivatives as new scaffolds for h A3 adenosine receptor antagonists
  166. Editorial (Hot Topic: Electrochemistry and Antioxidants)
  167. Hydroxycinnamic Acid Antioxidants: An Electrochemical Overview
  168. Combining QSAR classification models for predictive modeling of human monoamine oxidase inhibitors
  169. Host-Guest Interaction between Herbicide Oxadiargyl and Hydroxypropyl-β-Cyclodextrin
  170. Variable delay-to-signal: a fast paradigm for assessment of aspects of impulsivity in rats
  171. Photostabilization of Phenoxyacetic Acid Herbicides MCPA and Mecoprop by Hydroxypropyl-β-cyclodextrin
  172. Alzheimersche Demenz, Cholesterin und Statine: Berührungspunkte wichtiger Stoffwechselwege
  173. Alzheimer’s Disease, Cholesterol, and Statins: The Junctions of Important Metabolic Pathways
  174. Targeting adenosine receptors with coumarins: synthesis and binding activities of amide and carbamate derivatives
  175. Exploring Nitrostyrene as a Scaffold for a New Class a of Monoamine Oxidase Inhibitors
  176. Parkinson's Disease Management. Part II- Discovery of MAO-B Inhibitors Based on Nitrogen Heterocycles and Analogues
  177. Host-guest complexes of phenoxy alkyl acid herbicides and cyclodextrins. MCPA and β-cyclodextrin
  178. Desirability-Based Multi-Objective QSAR in Drug Discovery
  179. Discovery of MAO-B Inhibitors - Present Status and Future Directions Part I: Oxygen Heterocycles and Analogs
  180. Bridging the gap between nature and antioxidant setbacks: Delivering hydroxybenzoic acids to mitochondria
  181. Enhanced host–guest electrochemical recognition of herbicide MCPA using a β-cyclodextrin carbon nanotube sensor
  182. Exploring natural profits: Development of novel and potent galloyl-cinnamic hybrids lipophilic antioxidants
  183. In search for new chemical entities as adenosine receptor ligands: Development of agents based on benzo-γ-pyrone skeleton
  184. Bridging Chemical and Biological Space: QSAR Probing Using 3D Molecular Descriptors
  185. QSAR, Complex Networks, Principal Components and Partial Order Analysis of Drug Cardiotoxicity with Proteome Mass- Spectra Topological Indices
  186. Discovery of novel A3 adenosine receptor ligands based on chromone scaffold
  187. In vitro evaluation of bisnaphthalimidopropyl derivatives loaded into pegylated nanoparticles against Leishmania infantum protozoa
  188. Alkyl esters of hydroxycinnamic acids with improved antioxidant activity and lipophilicity protect PC12 cells against oxidative stress
  189. Simple Coumarins: Privileged Scaffolds in Medicinal Chemistry
  190. Recent Advances on A3 Adenosine Receptor Antagonists by QSAR Tools
  191. ChemInform Abstract: Accelerating Lead Optimization of Chromone Carboxamide Scaffold Throughout Microwave-Assisted Organic Synthesis.
  192. Rational discovery and development of a mitochondria-targeted antioxidant based on cinnamic acid scaffold
  193. 8-Substituted 3-Arylcoumarins as Potent and Selective MAO-B Inhibitors: Synthesis, Pharmacological Evaluation, and Docking Studies
  194. Improved Synthesis of 3-(Aminoaryl)coumarins
  195. Antioxidants and Stroke: Success and Pitfalls
  196. Studies on the Food Additive Propyl Gallate: Synthesis, Structural Characterization, and Evaluation of the Antioxidant Activity
  197. Jointly Handling Potency and Toxicity of Antimicrobial Peptidomimetics by Simple Rules from Desirability Theory and Chemoinformatics
  198. Wine and grape polyphenols—A chemical perspective
  199. Wine and grape polyphenols—A chemical perspective
  200. Accelerating lead optimization of chromone carboxamide scaffold throughout microwave-assisted organic synthesis
  201. Affinity prediction on A3 adenosine receptor antagonists: The chemometric approach
  202. Two New Parameters Based on Distances in a Receiver Operating Characteristic Chart for the Selection of Classification Models
  203. Molecular interaction between cocaine and opioids. Implications on Speedball's toxicity
  204. Chromone, a Privileged Scaffold for the Development of Monoamine Oxidase Inhibitors
  205. Methamphetamine transiently increases the blood–brain barrier permeability in the hippocampus: Role of tight junction proteins and matrix metalloproteinase-9
  206. ChemInform Abstract: Synthesis of 3‐Arylcoumarins via Suzuki Cross‐Coupling Reactions of 3‐Chlorocoumarin.
  207. Lipophilic Caffeic and Ferulic Acid Derivatives Presenting Cytotoxicity against Human Breast Cancer Cells
  208. An Electrochemical Outlook on Tamoxifen Biotransformation: Current and Future Prospects
  209. Hydration Structure of Cocaine and its Metabolites: A Molecular Dynamics Study
  210. Synthesis of 3-arylcoumarins via Suzuki-cross-coupling reactions of 3-chlorocoumarin
  211. Synthesis and antioxidant activity of long chain alkyl hydroxycinnamates
  212. Towards the Discovery of a Novel Class of Monoamine Oxidase Inhibitors: Structure-Property-Activity and Docking Studies on Chromone Amides
  213. Receptores A3 da adenosina: uma nova abordagem terapêutica no câncer
  214. Chromone 3-phenylcarboxamides as potent and selective MAO-B inhibitors
  215. Dietary Phenolic Acids and Derivatives. Evaluation of the Antioxidant Activity of Sinapic Acid and Its Alkyl Esters
  216. New halogenated 3-phenylcoumarins as potent and selective MAO-B inhibitors
  217. Neurotoxicity of heroin–cocaine combinations in rat cortical neurons
  218. Lipophilic phenolic antioxidants: Correlation between antioxidant profile, partition coefficients and redox properties
  219. Electrochemical oxidation of amphetamine-like drugs and application to electroanalysis of ecstasy in human serum
  220. Structure−Property−Activity Relationship of Phenolic Acids and Derivatives. Protocatechuic Acid Alkyl Esters
  221. Chromone-2- and -3-carboxylic acids inhibit differently monoamine oxidases A and B
  222. Prioritizing Hits with Appropriate Trade-Offs Between HIV-1 Reverse Transcriptase Inhibitory Efficacy and MT4 Blood Cells Toxicity Through Desirability-Based Multiobjective Optimization and Ranking
  223. Multidimensional Drug Design: Simultaneous Analysis of Binding and Relative Efficacy Profiles of N6-substituted-4′-thioadenosines A3 Adenosine Receptor Agonists
  224. Synthesis of Carbocyclic Pyrimidine Nucleosides Using theMitsunobuReaction:O2-vs. N1-Alkylation
  225. Unified QSAR & network-based computational chemistry approach to antimicrobials. II. Multiple distance and triadic census analysis of antiparasitic drugs complex networks
  226. Powerful Protective Role of 3,4-Dihydroxyphenylethanol−Elenolic Acid Dialdehyde against Erythrocyte Oxidative-Induced Hemolysis
  227. Synthesis and Vasorelaxant and Platelet Antiaggregatory Activities of a New Series of 6-Halo-3-phenylcoumarins
  228. The Anticancer Properties of Dietary Polyphenols and its Relation with Apoptosis
  229. Methamphetamine-induced neuroinflammation and neuronal dysfunction in the mice hippocampus: preventive effect of indomethacin
  230. Conformational behaviour of biologically active ferulic acid derivatives
  231. Multi-target spectral moments for QSAR and Complex Networks study of antibacterial drugs
  232. Multi-target spectral moment: QSAR for antiviral drugs vs. different viral species
  233. Multi-target spectral moment: QSAR for antifungal drugs vs. different fungi species
  234. Fluoxetine and Norfluoxetine Revisited: New Insights into the Electrochemical and Spectroscopic Properties
  235. ChemInform Abstract: Activation of Hydrocinnamic Acids with Pentafluorophenol versus Pentafluorothiophenol: Reactivity Towards Hexylamine.
  236. New insights into the antioxidant activity of hydroxycinnamic acids: Synthesis and physicochemical characterization of novel halogenated derivatives
  237. Effects of olive oil polyphenols on erythrocyte oxidative damage
  238. Total Arsenic Content in Seafood Consumed in Portugal
  239. Activation of hydrocinnamic acids with pentafluorophenol versus pentafluorothiophenol: Reactivity towards hexylamine
  240. Theoretical study of cocaine and ecgonine methyl ester in gas phase and in aqueous solution
  241. Desirability-based multiobjective optimization for global QSAR studies: Application to the design of novel NSAIDs with improved analgesic, antiinflammatory, and ulcerogenic profiles
  242. Desirability-Based Methods of Multiobjective Optimization and Ranking for Global QSAR Studies. Filtering Safe and Potent Drug Candidates from Combinatorial Libraries
  243. Quantitative Proteome–Property Relationships (QPPRs). Part 1: Finding biomarkers of organic drugs with mean Markov connectivity indices of spiral networks of blood mass spectra
  244. Stochastic molecular descriptors for polymers. 4. Study of complex mixtures with topological indices of mass spectra spiral and star networks: The blood proteome case
  245. Natural/random protein classification models based on star network topological indices
  246. Methamphetamine Changes NMDA and AMPA Glutamate Receptor Subunit Levels in the Rat Striatum and Frontal Cortex
  247. Methamphetamine-Induced Early Increase of IL-6 and TNF-α mRNA Expression in the Mouse Brain
  248. Antioxidant phenolic esters with potential anticancer activity: solution equilibria studied by Raman spectroscopy
  249. Voltammetric and DFT Studies on Viloxazine: Analytical Application to Pharmaceuticals and Biological Fluids
  250. Ligands and Therapeutic Perspectives of Adenosine A2A Receptors
  251. Antioxidant Versus Cytotoxic Properties of Hydroxycinnamic Acid Derivatives – A New Paradigm in Phenolic Research
  252. 3D-MEDNEs: An Alternative “in Silico” Technique for Chemical Research in Toxicology. 2. Quantitative Proteome−Toxicity Relationships (QPTR) based on Mass Spectrum Spiral Entropy
  253. Antioxidant phenolic esters with potential anticancer activity: A Raman spectroscopy study
  254. Methamphetamine induces alterations on hippocampal NMDA and AMPA receptor subunit levels and impairs spatial working memory
  255. Computational chemistry approach for the early detection of drug-induced idiosyncratic liver toxicity
  256. Voltammetric Insights in the Transfer of Ionizable Drugs Across Biomimetic Membranes - Recent Achievements
  257. Computational modeling tools for the design of potent antimalarial bisbenzamidines: Overcoming the antimalarial potential of pentamidine
  258. Computational chemistry development of a unified free energy Markov model for the distribution of 1300 chemicals to 38 different environmental or biological systems
  259. Electrochemical and spectroscopic characterisation of amphetamine-like drugs: Application to the screening of 3,4-methylenedioxymethamphetamine (MDMA) and its synthetic precursors
  260. Spectroscopic and electrochemical studies of cocaine–opioid interactions
  261. Square‐Wave Adsorptive‐Stripping Voltammetric Detection in the Quality Control of Fluoxetine
  262. Street heroin induces mitochondrial dysfunction and apoptosis in rat cortical neurons
  263. Phenolic esters with potential anticancer activity - the structural variable
  264. Evaluation of the lipophilic properties of opioids, amphetamine-like drugs, and metabolites through electrochemical studies at the interface between two immiscible solutions
  265. Synthesis and Cytotoxic Profile of 3,4-Methylenedioxymethamphetamine (“Ecstasy”) and Its Metabolites on Undifferentiated PC12 Cells:  A Putative Structure−Toxicity Relationship
  266. Simple stochastic fingerprints towards mathematical modeling in biology and medicine. 3. ocular irritability classification model
  267. Cytotoxic and COX-2 Inhibition Properties of Hydroxycinnamic Derivatives
  268. β-Nitrostyrene derivatives as potential antibacterial agents: A structure–property–activity relationship study
  269. Mitochondrial dysfunction and caspase activation in rat cortical neurons treated with cocaine or amphetamine
  270. Conformational analysis of the potential anticancer agent ethyl trihydroxycinnamate—A combined raman spectroscopy and ab initio study
  271. 2,2,4,4-Tetra-tert-butyl-1,3,5,2,4-benzotrioxadisilepine-7-carbaldehyde
  272. New insights on the anticancer properties of dietary polyphenols
  273. Single or multiple injections of methamphetamine increased dopamine turnover but did not decrease tyrosine hydroxylase levels or cleave caspase-3 in caudate-putamen
  274. Antioxidant profile of dihydroxy- and trihydroxyphenolic acids-A structure–activity relationship study
  275. Structure–property studies on the antioxidant activity of flavonoids present in diet
  276. Potentiometric studies on the complexation of copper(II) by phenolic acids as discrete ligand models of humic substances
  277. Simple Coumarins and Analogues in Medicinal Chemistry: Occurrence, Synthesis and Biological Activity
  278. Voltammetric Oxidation of Drugs of Abuse III. Heroin and Metabolites
  279. Voltammetric Oxidation of Drugs of Abuse I. Morphine and Metabolites
  280. Voltammetric Oxidation of Drugs of Abuse II. Codeine and Metabolites
  281. The toxicity of N-methyl-α-methyldopamine to freshly isolated rat hepatocytes is prevented by ascorbic acid and N-acetylcysteine
  282. Phenolic acid derivatives with potential anticancer properties––a structure–activity relationship study. Part 1: Methyl, propyl and octyl esters of caffeic and gallic acids
  283. Conformational analysis of a trihydroxylated derivative of cinnamic acid—a combined Raman spectroscopy and Ab initio study
  284. Metabolism Is Required for the Expression of Ecstasy-Induced Cardiotoxicity in Vitro
  285. β-Nitrostyrene derivatives—a conformational study by combined Raman spectroscopy and ab initio MO calculations
  286. Identification of synthetic precursors of amphetamine-like drugs using Raman spectroscopy and ab initio calculations: β-Methyl-β-nitrostyrene derivatives
  287. Electrochemical Analysis of Opiates—An Overview
  288. Hepatotoxicity of 3,4-methylenedioxyamphetamine and ?-methyldopamine in isolated rat hepatocytes: formation of glutathione conjugates
  289. Anticancer Activity of Phenolic Acids of Natural or Synthetic Origin:  A Structure−Activity Study
  290. 335 Metabolism is required for the expression of ecstasy-induced cardiotoxicity in vitro
  291. Application of a Potentiometric System with Data-Analysis Computer Programs to the Quantification of Metal-Chelating Activity of Two Natural Antioxidants: Caffeic Acid and Ferulic Acid
  292. 364 Hepatotoxic effects of 3,4-methylenedioxyamphetamine and α-methyldopamine in freshly isolated rat hepatocytes
  293. 365 The metabolism of 3,4-methylenedioxymethamphetamine (ecstasy) into N-methyl-α-methyldopamine drastically increases its in vitro toxicity
  294. Development of electrochemical methods for determination of tramadol—analytical application to pharmaceutical dosage forms
  295. Electrochemical and Spectroscopic Studies of the Oxidation Mechanism of the Herbicide Propanil
  296. Flow Injection Electrochemical Determination of Apomorphine
  297. Electrochemical Determination of Dihydrocodeine in Pharmaceuticals
  298. Synthesis and analysis of aminochromes by HPLC-photodiode array. Adrenochrome evaluation in rat blood
  299. Role of metabolites in MDMA (ecstasy)-induced nephrotoxicity: an in vitro study using rat and human renal proximal tubular cells
  300. New insights into the oxidation pathways of apomorphine
  301. ELECTROANALYTICAL DETERMINATION OF CODEINE IN PHARMACEUTICAL PREPARATIONS
  302. Oxidative behaviour of apomorphine and its metabolites
  303. Electrospray tandem mass spectrometry of aminochromes
  304. Effects of Phenolic Propyl Esters on the Oxidative Stability of Refined Sunflower Oil
  305. Electrochemical oxidation of propanil and related N-substituted amides
  306. Electroanalytical Determination of Oxadiazon and Characterization of Its Base-Catalyzed Ring-Opening Products
  307. Phenolic Acids and Derivatives:  Studies on the Relationship among Structure, Radical Scavenging Activity, and Physicochemical Parameters †
  308. Métodos para avaliação do grau de oxidação lipídica e da capacidade antioxidante
  309. 1H and13C NMR Spectroscopy of mono-, di-, tri- and tetrasubstituted xanthones
  310. Separation of the Diastereoisomers of Ethyl Esters of Caffeic, Ferulic, and Isoferulic Acids by Thin-Layer and High Performance Liquid Chromatography
  311. Simultaneous Isocratic HPLC Separation of the Diastereoisomers of Caffeic, Ferulic, and Isoferulic Acids and Related Coumarins
  312. Synthesis of Coumarins and Derivatives. Part 1. Biomimetic synthesis of esculetin and halogenated derivatives
  313. Isocratic HPLC Separation of Scopoletin andCis/TransIsomers of Ferulic Acid as Well as Isoscopoletin andCis/TransIsomers of Isoferulic Acid
  314. NMR studies on the antiradical mechanism of phenolic compounds towards 2,2-diphenyl-1-picrylhydrazyl radical