All Stories

  1. Enhanced Detection of Homology Using Artificial Intelligence in Euglenids
  2. A Ras-like GTPase in African trypanosomes
  3. A lineage-specific protein network at the trypanosome nuclear envelope
  4. Deviating from the norm: Nuclear organisation in trypanosomes
  5. Trypanosomes as a magnifying glass for cell and molecular biology
  6. Evolutionary, structural and functional insights in nuclear organisation and nucleocytoplasmic transport in trypanosomes
  7. Extracellular vesicles secreted by Echinococcus multilocularis: important players in angiogenesis promotion
  8. Evolution of cullin E3 ubiquitin ligases and function in trypanosomes
  9. Identification of inhibitors for the transmembrane Trypanosoma cruzi eIF2α kinase relevant for parasite proliferation
  10. Lessons from the deep: mechanisms behind diversification of eukaryotic protein complexes
  11. Functional differentiation of Sec13 paralogues in the euglenozoan protists
  12. Trypanosoma cruziVDU deubiquitinase mediates surface protein trafficking and infectivity
  13. Functional differentiation of Sec13 paralogs in the euglenozoan protists
  14. Sending the message: specialized RNA export mechanisms in trypanosomes
  15. Microbe Profile: Euglena gracilis: photogenic, flexible and hardy
  16. Correction to: Evolution of factors shaping the endoplasmic reticulum
  17. African trypanosome strategies for conquering new hosts and territories: the end of monophyly?
  18. Evolution of factors shaping the endoplasmic reticulum
  19. A novel membrane complex is required for docking and regulated exocytosis of lysosome-related organelles in Tetrahymena thermophila
  20. Proteomics Uncovers Novel Components of an Interactive Protein Network Supporting RNA Export in Trypanosomes
  21. The distinctive flagellar proteome of Euglena gracilis illuminates the complexities of protistan flagella adaptation
  22. Evolution and diversification of the nuclear pore complex
  23. A hub-and-spoke nuclear lamina architecture in trypanosomes
  24. Kinetoplastid cell biology and genetics, from the 2020 British Society for Parasitology Trypanosomiasis and Leishmaniasis symposium, Granada, Spain
  25. Evolving Differentiation in African Trypanosomes
  26. Evolution, function and roles in drug sensitivity of trypanosome aquaglyceroporins
  27. Evolution and diversification of the nuclear envelope
  28. The endosomal TbTpr86/TbUsp7/SkpZ (TUS) complex controls surface protein abundance in trypanosomes
  29. EIF2αphosphorylation is regulated in intracellular amastigotes for the generation of infectiveTrypanosoma cruzitrypomastigote forms
  30. Instability of aquaglyceroporin (AQP) 2 contributes to drug resistance in Trypanosoma brucei
  31. A Uniquely Complex Mitochondrial Proteome from Euglena gracilis
  32. Evolution of late steps in exocytosis: conservation and specialization of the exocyst complex
  33. Evolution of late steps in exocytosis: conservation, specialization
  34. Monoallelic expression and epigenetic inheritance sustained by a Trypanosoma brucei variant surface glycoprotein exclusion complex
  35. Pore timing: the evolutionary origins of the nucleus and nuclear pore complex
  36. Evolution of protein trafficking in kinetoplastid parasites: Complexity and pathogenesis
  37. Adaptation and Therapeutic Exploitation of the Plasma Membrane of African Trypanosomes
  38. Adaptation and Therapeutic Exploitation of the Plasma Membrane of African Trypanosomes
  39. Regulation of early endosomes across eukaryotes: Evolution and functional homology of Vps9 proteins
  40. Unlocking the biological potential ofEuglena gracilis: evolution, cell biology and significance to parasitism
  41. Comparative interactomics provides evidence for functional specialization of the nuclear pore complex
  42. Evolution of the endomembrane systems of trypanosomatids – conservation and specialisation
  43. Lineage-specific proteins essential for endocytosis in trypanosomes
  44. A leucine aminopeptidase is involved in kinetoplast DNA segregation in Trypanosoma brucei
  45. Specialising the parasite nucleus: Pores, lamins, chromatin, and diversity
  46. The Trypanosome Exocyst: A Conserved Structure Revealing a New Role in Endocytosis
  47. Exploiting the Achilles’ heel of membrane trafficking in trypanosomes
  48. The changing view of eukaryogenesis – fossils, cells, lineages and how they all come together
  49. Co-dependence between trypanosome nuclear lamina components in nuclear stability and control of gene expression
  50. Making the pathogen: Evolution and adaptation in parasitic protists
  51. Resolving the homology—function relationship through comparative genomics of membrane-trafficking machinery and parasite cell biology
  52. Conservation and divergence within the clathrin interactome of Trypanosoma cruzi
  53. Ancient Eukaryotic Origin and Evolutionary Plasticity of Nuclear Lamina
  54. Genome of Leptomonas pyrrhocoris: a high-quality reference for monoxenous trypanosomatids and new insights into evolution of Leishmania
  55. Interactome Mapping Reveals the Evolutionary History of the Nuclear Pore Complex
  56. Kinetoplastid Phylogenomics Reveals the Evolutionary Innovations Associated with the Origins of Parasitism
  57. Subunit connectivity, assembly determinants and architecture of the yeast exocyst complex
  58. Correction: Modulation of the Surface Proteome through Multiple Ubiquitylation Pathways in African Trypanosomes
  59. Phosphoinositides, kinases and adaptors coordinating endocytosis in Trypanosoma brucei
  60. Modulation of the Surface Proteome through Multiple Ubiquitylation Pathways in African Trypanosomes
  61. Quantitative sequencing confirms VSG diversity as central to immune evasion by Trypanosoma brucei
  62. Architecture of a Host–Parasite Interface: Complex Targeting Mechanisms Revealed Through Proteomics
  63. Localization of serum resistance-associated protein inTrypanosoma brucei rhodesienseand transgenicTrypanosoma brucei brucei
  64. ENTH and ANTH domain proteins participate in AP2-independent clathrin-mediated endocytosis
  65. Evolutionary cell biology: Two origins, one objective
  66. The mitochondrial respiratory chain of the secondary green alga Euglena gracilis shares many additional subunits with parasitic Trypanosomatidae
  67. An extensive endoplasmic reticulum-localised glycoprotein family in trypanosomatids
  68. Missing Pieces of an Ancient Puzzle: Evolution of the Eukaryotic Membrane-Trafficking System
  69. A draft genome for the African crocodilian trypanosome Trypanosoma grayi
  70. Touching from a distance
  71. Evolution of the nucleus
  72. Life and times: synthesis, trafficking, and evolution of VSG
  73. Nuclear pore complex evolution: a trypanosome Mlp analogue functions in chromosomal segregation but lacks transcriptional barrier activity
  74. A comparative analysis of trypanosomatid SNARE proteins
  75. The Streamlined Genome of Phytomonas spp. Relative to Human Pathogenic Kinetoplastids Reveals a Parasite Tailored for Plants
  76. The Cell Biology of the Endocytic System from an Evolutionary Perspective
  77. Enriching the Pore: Splendid Complexity from Humble Origins
  78. The Ancient Small GTPase Rab21 Functions in Intermediate Endocytic Steps in Trypanosomes
  79. Antigenic variation in African trypanosomes: the importance of chromosomal and nuclear context inVSGexpression control
  80. Molecular paleontology and complexity in the last eukaryotic common ancestor
  81. Cell density-dependent ectopic expression in bloodstream form Trypanosoma brucei
  82. Receptor-mediated endocytosis for drug delivery in African trypanosomes: fulfilling Paul Ehrlich's vision of chemotherapy
  83. Evolution of modular intraflagellar transport from a coatomer-like progenitor
  84. Adaptin evolution in kinetoplastids and emergence of the variant surface glycoprotein coat in African trypanosomatids
  85. A Cell-surface Phylome for African Trypanosomes
  86. Evolution of Tre-2/Bub2/Cdc16 (TBC) Rab GTPase-activating proteins
  87. TbFRP, a novel FYVE-domain containing phosphoinositide-binding Ras-like GTPase from trypanosomes
  88. Proteomic Analysis of Clathrin Interactions in Trypanosomes Reveals Dynamic Evolution of Endocytosis
  89. Differential Localization of the Two T. brucei Poly(A) Binding Proteins to the Nucleus and RNP Granules Suggests Binding to Distinct mRNA Pools
  90. An automated graphics tool for comparative genomics: the Coulson plot generator
  91. Evidence for Recycling of Invariant Surface Transmembrane Domain Proteins in African Trypanosomes
  92. Pyrimidine Salvage in Trypanosoma brucei Bloodstream Forms and the Trypanocidal Action of Halogenated Pyrimidines
  93. Telomeres, tethers and trypanosomes
  94. RAB-Like 2 Has an Essential Role in Male Fertility, Sperm Intra-Flagellar Transport, and Tail Assembly
  95. Epigenetic mechanisms, nuclear architecture and the control of gene expression in trypanosomes
  96. Terminal galactosylation of glycoconjugates in Plasmodium falciparum asexual blood stages and Trypanosoma brucei bloodstream trypomastigotes
  97. NUP-1 Is a Large Coiled-Coil Nucleoskeletal Protein in Trypanosomes with Lamin-Like Functions
  98. Sculpting the endomembrane system in deep time: high resolution phylogenetics of Rab GTPases
  99. Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species
  100. Proteomics on the rims: insights into the biology of the nuclear envelope and flagellar pocket of trypanosomes
  101. High-throughput decoding of antitrypanosomal drug efficacy and resistance
  102. Rab28 function in trypanosomes: interactions with retromer and ESCRT pathways
  103. A Novel Rho-Like Protein TbRHP Is Involved in Spindle Formation and Mitosis in Trypanosomes
  104. Specializations in a successful parasite: What makes the bloodstream-form African trypanosome so deadly?
  105. High Affinity Nanobodies against the Trypanosome brucei VSG Are Potent Trypanolytic Agents that Block Endocytosis
  106. On a bender—BARs, ESCRTs, COPs, and finally getting your coat
  107. Rab11 Function in Trypanosoma brucei: Identification of Conserved and Novel Interaction Partners
  108. Ubiquitylation and Developmental Regulation of Invariant Surface Protein Expression in Trypanosomes
  109. Evolution of the Karyopherin-β Family of Nucleocytoplasmic Transport Factors; Ancient Origins and Continued Specialization
  110. Evolutionary reconstruction of the retromer complex and its function in Trypanosoma brucei
  111. Trypanosoma brucei brucei: Endocytic recycling is important for mouse infectivity
  112. A Conserved Coatomer-related Complex Containing Sec13 and Seh1 Dynamically Associates With the Vacuole in Saccharomyces cerevisiae
  113. Rab23 is a flagellar protein in Trypanosoma brucei
  114. Regulation of Thromboxane Receptor Signaling at Multiple Levels by Oxidative Stress-Induced Stabilization, Relocation and Enhanced Responsiveness
  115. Trypanosoma brucei: Trypanosome-specific endoplasmic reticulum proteins involved in variant surface glycoprotein expression
  116. Rab protein evolution and the history of the eukaryotic endomembrane system
  117. The Genome of Naegleria gruberi Illuminates Early Eukaryotic Versatility
  118. Chaperone Requirements for Biosynthesis of the Trypanosome Variant Surface Glycoprotein
  119. Evidence that low endocytic activity is not directly responsible for human serum resistance in the insect form of African trypanosomes
  120. The trypanosome flagellar pocket
  121. The Trypanosome Rab-Related Proteins RabX1 and RabX2 Play No Role in IntraCellular Trafficking but May Be Involved in Fly Infectivity
  122. Evidence for a Shared Nuclear Pore Complex Architecture That Is Conserved from the Last Common Eukaryotic Ancestor
  123. Drug screening by crossing membranes: a novel approach to identification of trypanocides
  124. The Single ENTH-Domain Protein of Trypanosomes; Endocytic Functions and Evolutionary Relationship with Epsin
  125. First and last ancestors: reconstructing evolution of the endomembrane system with ESCRTs, vesicle coat proteins, and nuclear pore complexes
  126. Evolution of specificity in the eukaryotic endomembrane system
  127. Chapter 1 Macromolecular Trafficking and Immune Evasion in African Trypanosomes
  128. Ubiquitylation is Required for Degradation of Transmembrane Surface Proteins in Trypanosomes
  129. Evolution of the Multivesicular Body ESCRT Machinery; Retention Across the Eukaryotic Lineage
  130. Implications of the new eukaryotic systematics for parasitologists
  131. How complex is GTPase signaling in trypanosomes?
  132. Phylogeny of endocytic components yields insight into the process of nonendosymbiotic organelle evolution
  133. The trypanosome transcriptome is remodelled during differentiation but displays limited responsiveness within life stages
  134. Analysis of Small GTPase Function in Trypanosomes
  135. Dileucine signal-dependent and AP-1-independent targeting of a lysosomal glycoprotein in Trypanosoma brucei
  136. Activation of Endocytosis as an Adaptation to the Mammalian Host by Trypanosomes
  137. Evolution of the eukaryotic membrane-trafficking system: origin, tempo and mode
  138. Intracellular Trafficking in the Trypanosomatids
  139. Chromosome-Wide Analysis of Gene Function by RNA Interference in the African Trypanosome
  140. TbVps34, the Trypanosome Orthologue of Vps34, Is Required for Golgi Complex Segregation
  141. Dramatic reorganisation of Trichomonas endomembranes during amoebal transformation: A possible role for G-proteins☆
  142. Electrical and optical performance of InAs/GaSb superlattice LWIR detectors
  143. Trypanosoma brucei: TbRAB4 regulates membrane recycling and expression of surface proteins in procyclic forms
  144. Signalling the genome: the Ras-like small GTPase family of trypanosomatids
  145. Identification of a very large Rab GTPase family in the parasitic protozoan Trichomonas vaginalis
  146. ER-associated protein degradation is a common mechanism underpinning numerous monogenic diseases including Robinow syndrome
  147. The Genome of the African Trypanosome Trypanosoma brucei
  148. An Evolutionarily Conserved Coiled-Coil Protein Implicated in Polycystic Kidney Disease Is Involved in Basal Body Duplication and Flagellar Biogenesis in Trypanosoma brucei
  149. Developmental Variation in Rab11-Dependent Trafficking in Trypanosoma brucei
  150. A bioinformatic analysis of the RAB genes of Trypanosoma brucei
  151. The role of alternative splicing and C-terminal amino acids in thromboxane receptor stabilization
  152. Perturbation of local endogenous expression by insertion of Pol I expression constructs into the genome of Trypanosoma brucei
  153. Reconstitution of glycopeptide export in mixed detergent-solubilised and resealed microsomes depleted of lumenal components
  154. Leishmania major: clathrin and adaptin complexes of an intra-cellular parasite
  155. Both of the Rab5 subfamily small GTPases of Trypanosoma brucei are essential and required for endocytosis
  156. Intracellular Membrane Transport Systems in Trypanosoma brucei
  157. TbRAB1 and TbRAB2 mediate trafficking through the early secretory pathway of Trypanosoma brucei
  158. New Approaches to the Microscopic Imaging of Trypanosoma brucei
  159. Cytoplasmic Targeting Signals in Transmembrane Invariant Surface Glycoproteins of Trypanosomes
  160. TbRAB23; a nuclear-associated Rab protein from Trypanosoma brucei
  161. Rab4 Is an Essential Regulator of Lysosomal Trafficking in Trypanosomes
  162. The Single Dynamin-like Protein of Trypanosoma brucei Regulates Mitochondrial Division and Is Not Required for Endocytosis
  163. The Mechanism of Oxidative Stress Stabilization of the Thromboxane Receptor in COS-7 Cells
  164. Clathrin-mediated endocytosis is essential in Trypanosoma brucei
  165. Rab5 and Rab11 mediate transferrin and anti-variant surface glycoprotein antibody recycling in Trypanosoma brucei
  166. Biochemical and genetic evidence for a family of heterotrimeric G-proteins in Trichomonas vaginalis
  167. RNAit: an automated web-based tool for the selection of RNAi targets in Trypanosoma brucei
  168. Endocytosis of a Glycosylphosphatidylinositol-anchored Protein via Clathrin-coated Vesicles, Sorting by Default in Endosomes, and Exocytosis via RAB11-positive Carriers
  169. Essential Roles for GPI-anchored Proteins in African Trypanosomes Revealed Using Mutants Deficient in GPI8
  170. The endocytic apparatus of the kinetoplastida. Part II: machinery and components of the system
  171. The kinetoplastida endocytic apparatus. Part I: a dynamic system for nutrition and evasion of host defences
  172. Leishmania RAB7: characterisation of terminal endocytic stages in an intracellular parasite
  173. Evidence for a non-LDL-mediated entry route for the trypanocidal drug suramin in Trypanosoma brucei
  174. TbRAB18, a developmentally regulated Golgi GTPase from Trypanosoma brucei
  175. Differential Endocytic Functions ofTrypanosoma brucei Rab5 Isoforms Reveal a Glycosylphosphatidylinositol-specific Endosomal Pathway
  176. Isolation and Characterization of Subnuclear Compartments from Trypanosoma brucei
  177. GPI-anchored proteins and glycoconjugates segregate into lipid rafts in Kinetoplastida
  178. Export of a misprocessed GPI-anchored protein from the endoplasmic reticulum in vitro in an ATP- and cytosol-dependent manner
  179. A Microsomal GTPase Is Required for Glycopeptide Export from the Mammalian Endoplasmic Reticulum
  180. Erratum to “Cell-cycle and developmental regulation of TbRAB31 localisation, a GTP-locked Rab protein from Trypanosoma brucei”[Mol. Biochem. Parasitol. 106 (2000) 21–35]
  181. Acylation-dependent Protein Export in Leishmania
  182. Cell-cycle and developmental regulation of TbRAB31 localisation, a GTP-locked Rab protein from Trypanosoma brucei
  183. The farnesyltransferase inhibitor manumycin A is a novel trypanocide with a complex mode of action including major effects on mitochondria
  184. GTPases in Protozoan Parasites: Tools for Cell Biology and Chemotherapy
  185. Complexity of Trypanosomatid Endocytosis Pathways Revealed by Rab4 and Rab5 Isoforms in Trypanosoma brucei
  186. Tandem Duplication of rab Genes Followed by Sequence Divergence and Acquisition of Distinct Functions in Trypanosoma brucei
  187. Characterisation of protein isoprenylation in procyclic form Trypanosoma brucei
  188. Leptomonas seymouri, Trypanosoma brucei:A Method for Isolating Trypanosomatid Nuclear Factors Which BindT. bruceiSingle-Stranded g-Rich Telomere Sequence
  189. Sequence divergence in a family of variant surface glycoprotein genes from trypanosomes: Coding region hypervariability and downstream recombinogenic repeats
  190. Trypanosoma brucei: Molecular Cloning of Homologues of Small GTP-Binding Proteins Involved in Vesicle Trafficking
  191. A homologue of the nuclear GTPase Ran/TC4 from Trypanosoma brucei
  192. Molecular species analysis of phospholipids from Trypanosoma brucei bloodstream and procyclic forms
  193. Characterization of a glycosylphosphatidylinositol membrane protein anchor precursor in Leishmania mexicana