All Stories

  1. A mycobacterial Sec61 inhibitor disrupts lysosome function by blocking Vacuolar-ATPase biosynthesis

    Article • August 2025, Cold Spring Harbor Laboratory Press

    Belinda Hall

  2. The Mycobacterium ulcerans toxin mycolactone causes destructive Sec61-dependent loss of the endothelial glycocalyx and vessel basement membrane to drive skin necrosis

    Article • eLife, February 2025, eLife

    Belinda Hall

  3. Mycolactone causes destructive Sec61-dependent loss of the endothelial glycocalyx and vessel basement membrane: a new indirect mechanism driving tissue necrosis in Mycobacterium ulcerans infection

    Article • November 2024, eLife

    Professor Antonio Fernandez, Belinda Hall

  4. Synthesis, Biological Evaluation and Docking Studies of Ring-Opened Analogues of Ipomoeassin F

    Article • Molecules, July 2022, MDPI AG

    Wei Shi, Belinda Hall, Dr Sarah O'Keefe

  5. Aberrant stromal tissue factor localisation and mycolactone-driven vascular dysfunction, exacerbated by IL-1β, are linked to fibrin formation in Buruli ulcer lesions

    Article • PLoS Pathogens, January 2022, PLOS

    Rachel Simmonds, Belinda Hall

  6. The One That Got Away: How Macrophage-Derived IL-1β Escapes the Mycolactone-Dependent Sec61 Blockade in Buruli Ulcer

    Article • Frontiers in Immunology, January 2022, Frontiers

    Belinda Hall

  7. Mycolactone enhances the Ca2+ leak from endoplasmic reticulum by trapping Sec61 translocons in a Ca2+ permeable state

    Article • Biochemical Journal, November 2021, Portland Press Ltd.

    Belinda Hall

  8. Murine Norovirus Infection Results in Anti-inflammatory Response Downstream of Amino Acid Depletion in Macrophages

    Article • Journal of Virology, September 2021, ASM Journals

    Belinda Hall

  9. Inhibition of the SEC61 translocon by mycolactone induces a protective autophagic response controlled by EIF2S1-dependent translation that does not require ULK1 activity

    Article • Autophagy, August 2021, Taylor & Francis

    Belinda Hall

  10. TbSAP is a novel chromatin protein repressing metacyclic variant surface glycoprotein expression sites in bloodstream form Trypanosoma brucei

    Article • Nucleic Acids Research, February 2021, Oxford University Press (OUP)

    Belinda Hall

  11. Structure of the Inhibited State of the Sec Translocon

    Article • Molecular Cell, August 2020, Elsevier

    Belinda Hall

  12. Norovirus infection results in eIF2α independent host translation shut-off and remodels the G3BP1 interactome evading stress granule formation

    Article • PLoS Pathogens, January 2020, PLOS

    Belinda Hall

  13. Dynamic colocalization of 2 simultaneously active VSG expression sites within a single expression-site body in Trypanosoma brucei

    Article • Proceedings of the National Academy of Sciences, July 2019, Proceedings of the National Academy of Sciences

    Belinda Hall

  14. Ipomoeassin F Binds Sec61α to Inhibit Protein Translocation

    Article • Journal of the American Chemical Society, May 2019, American Chemical Society (ACS)

    Dr Sarah O'Keefe, Wei Shi, Belinda Hall

  15. Inhibition of Sec61-dependent translocation by mycolactone uncouples the integrated stress response from ER stress, driving cytotoxicity via translational activation of ATF4

    Article • Cell Death and Disease, March 2018, Springer Science + Business Media

    Belinda Hall

  16. The role of genomic location and flanking 3′UTR in the generation of functional levels of variant surface glycoprotein in Trypanosoma brucei

    Article • Molecular Microbiology, October 2017, Wiley

    Belinda Hall

  17. Mycolactone-Dependent Depletion of Endothelial Cell Thrombomodulin Is Strongly Associated with Fibrin Deposition in Buruli Ulcer Lesions

    Article • PLoS Pathogens, July 2015, PLOS

    Belinda Hall

  18. The Pathogenic Mechanism of the Mycobacterium ulcerans Virulence Factor, Mycolactone, Depends on Blockade of Protein Translocation into the ER

    Article • PLoS Pathogens, April 2014, PLOS

    Belinda Hall

  19. Megazol and its bioisostere 4H-1,2,4-triazole: comparing the trypanocidal, cytotoxic and genotoxic activities and their in vitro and in silico interactions with the Trypanosoma brucei nitroreductase enzyme

    Article • Memórias do Instituto Oswaldo Cruz, March 2014, FapUNIFESP (SciELO)

    Belinda Hall

  20. Pleiotropic molecular effects of theMycobacterium ulceransvirulence factor mycolactone underlying the cell death and immunosuppression seen in Buruli ulcer

    Article • Biochemical Society Transactions, January 2014, Portland Press Ltd.

    Belinda Hall

  21. Synthesis and anti-parasitic activity of a novel quinolinone–chalcone series

    Article • Bioorganic & Medicinal Chemistry Letters, December 2013, Elsevier

    Belinda Hall

  22. An Essential Type I Nitroreductase from Leishmania major Can Be Used to Activate Leishmanicidal Prodrugs

    Article • Journal of Biological Chemistry, October 2013, Elsevier

    Belinda Hall

  23. Evaluating 5-Nitrofurans as Trypanocidal Agents

    Article • Antimicrobial Agents and Chemotherapy, January 2013, ASM Journals

    Belinda Hall

  24. Targeting the Substrate Preference of a Type I Nitroreductase To Develop Antitrypanosomal Quinone-Based Prodrugs

    Article • Antimicrobial Agents and Chemotherapy, September 2012, ASM Journals

    Belinda Hall

  25. Benznidazole-Resistance in Trypanosoma cruzi Is a Readily Acquired Trait That Can Arise Independently in a Single Population

    Article • The Journal of Infectious Diseases, May 2012, Oxford University Press (OUP)

    Belinda Hall

  26. Activation of Benznidazole by Trypanosomal Type I Nitroreductases Results in Glyoxal Formation

    Article • Antimicrobial Agents and Chemotherapy, October 2011, ASM Journals

    Belinda Hall

  27. Trypanocidal Activity of Nitroaromatic Prodrugs: Current Treatments and Future Perspectives

    Article • Current Topics in Medicinal Chemistry, August 2011, Bentham Science Publishers

    Belinda Hall

  28. Synthesis and structure–activity relationships of nitrobenzyl phosphoramide mustards as nitroreductase-activated prodrugs

    Article • Bioorganic & Medicinal Chemistry Letters, July 2011, Elsevier

    Belinda Hall

  29. Nifurtimox Activation by Trypanosomal Type I Nitroreductases Generates Cytotoxic Nitrile Metabolites

    Article • Journal of Biological Chemistry, April 2011, Elsevier

    Belinda Hall

  30. Trypanocidal Activity of Aziridinyl Nitrobenzamide Prodrugs

    Article • Antimicrobial Agents and Chemotherapy, August 2010, ASM Journals

    Belinda Hall

  31. Exploiting the Drug-Activating Properties of a Novel Trypanosomal Nitroreductase

    Article • Antimicrobial Agents and Chemotherapy, December 2009, ASM Journals

    Belinda Hall

  32. TbVps34, the Trypanosome Orthologue of Vps34, Is Required for Golgi Complex Segregation

    Article • Journal of Biological Chemistry, July 2006, American Society for Biochemistry & Molecular Biology (ASBMB)

    Prof Mark C Field, Belinda Hall

  33. Trypanosoma brucei: TbRAB4 regulates membrane recycling and expression of surface proteins in procyclic forms

    Article • Experimental Parasitology, November 2005, Elsevier

    Prof Mark C Field, Belinda Hall

  34. Developmental Variation in Rab11-Dependent Trafficking in Trypanosoma brucei

    Article • Eukaryotic Cell, May 2005, ASM Journals

    Prof Mark C Field, Belinda Hall

  35. Both of the Rab5 subfamily small GTPases of Trypanosoma brucei are essential and required for endocytosis

    Article • Molecular and Biochemical Parasitology, November 2004, Elsevier

    Prof Mark C Field, Belinda Hall

  36. New Approaches to the Microscopic Imaging of Trypanosoma brucei

    Article • Microscopy and Microanalysis, October 2004, Cambridge University Press

    Prof Mark C Field, Belinda Hall

  37. Rab4 Is an Essential Regulator of Lysosomal Trafficking in Trypanosomes

    Article • Journal of Biological Chemistry, July 2004, American Society for Biochemistry & Molecular Biology (ASBMB)

    Prof Mark C Field, Belinda Hall

  38. Rab5 and Rab11 mediate transferrin and anti-variant surface glycoprotein antibody recycling in Trypanosoma brucei

    Article • Biochemical Journal, September 2003, Portland Press Ltd.

    Prof Mark C Field, Belinda Hall

  39. The endocytic apparatus of the kinetoplastida. Part II: machinery and components of the system

    Article • Trends in Parasitology, December 2002, Elsevier

    Prof Mark C Field, Belinda Hall

  40. The kinetoplastida endocytic apparatus. Part I: a dynamic system for nutrition and evasion of host defences

    Article • Trends in Parasitology, November 2002, Elsevier

    Prof Mark C Field, Belinda Hall

  41. Evidence for a non-LDL-mediated entry route for the trypanocidal drug suramin in Trypanosoma brucei

    Article • Molecular and Biochemical Parasitology, July 2002, Elsevier

    Prof Mark C Field, Belinda Hall

  42. Differential Endocytic Functions ofTrypanosoma brucei Rab5 Isoforms Reveal a Glycosylphosphatidylinositol-specific Endosomal Pathway

    Article • Journal of Biological Chemistry, December 2001, American Society for Biochemistry & Molecular Biology (ASBMB)

    Prof Mark C Field, Belinda Hall

  43. A Model for Sequestration of the Transmission Stages of Plasmodium falciparum: Adhesion of Gametocyte-Infected Erythrocytes to Human Bone Marrow Cells

    Article • Infection and Immunity, June 2000, ASM Journals

    Belinda Hall

  44. Dual Role for Transforming Growth Factor β-Dependent Signaling in Trypanosoma cruzi Infection of Mammalian Cells

    Article • Infection and Immunity, April 2000, ASM Journals

    Belinda Hall

  45. Multiple tyrosine protein kinases structurally related to p56lck are down-regulated following mitogenic stimulation of human T lymphocytes

    Article • Biochemical and Biophysical Research Communications, July 1990, Elsevier

    Belinda Hall

  46. Two major tyrosine protein kinases of resting human T lymphocytes are down‐regulated following mitotic stimulation

    Article • FEBS Letters, October 1987, Wiley

    Belinda Hall