All Stories

  1. Quantitative assessment of the 3D pore space and microglobule clustering network to understand chromatographic transport phenomena in polymeric monolithic columns

    Article • Chemical Engineering Journal, November 2024, Elsevier

    Prof. Dr. ir. Benoit Stijlemans

  2. Infection history imprints prolonged changes to the epigenome, transcriptome and function of Kupffer cells

    Article • Journal of Hepatology, July 2024, Elsevier

    Prof. Dr. ir. Benoit Stijlemans

  3. Beyond the VSG layer: Exploring the role of intrinsic disorder in the invariant surface glycoproteins of African trypanosomes

    Article • PLoS Pathogens, April 2024, PLOS

    Prof. Dr. ir. Benoit Stijlemans

  4. Q586B2 is a crucial virulence factor during the early stages of Trypanosoma brucei infection that is conserved amongst trypanosomatids

    Article • Nature Communications, February 2024, Springer Science + Business Media

    Prof. Dr. ir. Benoit Stijlemans

  5. Immunology of African Trypanosomiasis

    Article • January 2024, Elsevier

    Prof. Dr. ir. Benoit Stijlemans

  6. Trypanosomiasis

    Article • January 2024, Elsevier

    Prof. Dr. ir. Benoit Stijlemans

  7. Lipocalin-2: A Nurturer of Tumor Progression and a Novel Candidate for Targeted Cancer Therapy

    Article • Cancers, October 2023, MDPI AG

    Prof. Dr. ir. Benoit Stijlemans

  8. A few good reasons to use nanobodies for cancer treatment

    Article • European Journal of Immunology, June 2023, Wiley

    Prof. Dr. ir. Benoit Stijlemans

  9. Hallmarks of Cancer Affected by the MIF Cytokine Family

    Article • Cancers, January 2023, MDPI AG

    Prof. Dr. ir. Benoit Stijlemans

  10. Differential plasticity and fate of brain-resident and recruited macrophages during the onset and resolution of neuroinflammation

    Article • Immunity, November 2022, Elsevier

    Prof. Dr. ir. Benoit Stijlemans

  11. The Role of MIF and IL-10 as Molecular Yin-Yang in the Modulation of the Host Immune Microenvironment During Infections: African Trypanosome Infections as a Paradigm

    Article • Frontiers in Immunology, April 2022, Frontiers

    Prof. Dr. ir. Benoit Stijlemans

  12. Detrimental Effect ofTrypanosoma brucei bruceiInfection on Memory B Cells and Host Ability to Recall Protective B-cell Responses

    Article • The Journal of Infectious Diseases, April 2022, Oxford University Press (OUP)

    Prof. Dr. ir. Benoit Stijlemans

  13. Targeting the tsetse-trypanosome interplay using genetically engineered Sodalis glossinidius

    Article • PLoS Pathogens, March 2022, PLOS

    Prof. Dr. ir. Benoit Stijlemans

  14. Macrophages are metabolically heterogeneous within the tumor microenvironment

    Article • Cell Reports, December 2021, Elsevier

    Prof. Dr. ir. Benoit Stijlemans

  15. The Road to Personalized Myeloma Medicine: Patient-specific Single-domain Antibodies for Anti-idiotypic Radionuclide Therapy

    Article • Molecular Cancer Therapeutics, October 2021, American Association for Cancer Research (AACR)

    Prof. Dr. ir. Benoit Stijlemans

  16. Macrophage miR-210 induction and metabolic reprogramming in response to pathogen interaction boost life-threatening inflammation

    Article • Science Advances, May 2021, American Association for the Advancement of Science

    Prof. Dr. ir. Benoit Stijlemans

  17. Immunogenicity Risk Profile of Nanobodies

    Article • Frontiers in Immunology, March 2021, Frontiers

    Prof. Dr. ir. Benoit Stijlemans

  18. A Critical Blimp-1-Dependent IL-10 Regulatory Pathway in T Cells Protects From a Lethal Pro-inflammatory Cytokine Storm During Acute Experimental Trypanosoma brucei Infection

    Article • Frontiers in Immunology, June 2020, Frontiers

    Prof. Dr. ir. Benoit Stijlemans

  19. Dehydrin ERD14 activates glutathione transferase Phi9 in Arabidopsis thaliana under osmotic stress

    Article • Biochimica et Biophysica Acta (BBA) - General Subjects, March 2020, Elsevier

    Prof. Dr. ir. Benoit Stijlemans

  20. Development of a recombinase polymerase amplification lateral flow assay for the detection of active Trypanosoma evansi infections

    Article • PLoS Neglected Tropical Diseases, February 2020, PLOS

    Prof. Dr. ir. Benoit Stijlemans

  21. A New Family of Diverse Skin Peptides from the Microhylid Frog Genus Phrynomantis

    Article • Molecules, February 2020, MDPI AG

    Prof. Dr. ir. Benoit Stijlemans

  22. Hepatocyte-derived IL-10 plays a crucial role in attenuating pathogenicity during the chronic phase of T. congolense infection

    Article • PLoS Pathogens, February 2020, PLOS

    Prof. Dr. ir. Benoit Stijlemans

  23. Identification of Nanobodies against the Acute Myeloid Leukemia Marker CD33

    Article • International Journal of Molecular Sciences, January 2020, MDPI AG

    Prof. Dr. ir. Benoit Stijlemans

  24. The Trypanosomal Transferrin Receptor of Trypanosoma Brucei—A Review

    Article • Tropical Medicine and Infectious Disease, October 2019, MDPI AG

    Prof. Dr. ir. Benoit Stijlemans

  25. Neutrophils enhance early Trypanosoma brucei infection onset

    Article • Scientific Reports, July 2018, Springer Science + Business Media

    Prof. Dr. ir. Benoit Stijlemans

  26. Novel half-life extended anti-MIF nanobodies protect against endotoxic shock

    Article • The FASEB Journal, June 2018, Federation of American Societies For Experimental Biology (FASEB)

    Prof. Dr. ir. Benoit Stijlemans

  27. The anuran skin peptide bradykinin mediates its own absorption across epithelial barriers of the digestive tract

    Article • Peptides, March 2018, Elsevier

    Prof. Dr. ir. Benoit Stijlemans

  28. African Trypanosomiasis-Associated Anemia: The Contribution of the Interplay between Parasites and the Mononuclear Phagocyte System

    Article • Frontiers in Immunology, February 2018, Frontiers

    Prof. Dr. ir. Benoit Stijlemans

  29. MIF inhibition interferes with the inflammatory and T cell-stimulatory capacity of NOD macrophages and delays autoimmune diabetes onset

    Article • PLoS ONE, November 2017, PLOS

    Prof. Dr. ir. Benoit Stijlemans

  30. Nanobodies As Tools to Understand, Diagnose, and Treat African Trypanosomiasis

    Article • Frontiers in Immunology, June 2017, Frontiers

    Prof. Dr. ir. Benoit Stijlemans

  31. Reprint of: The non-mammalian MIF superfamily

    Article • Immunobiology, June 2017, Elsevier

    Prof. Dr. ir. Benoit Stijlemans

  32. African Trypanosomes Undermine Humoral Responses and Vaccine Development: Link with Inflammatory Responses?

    Article • Frontiers in Immunology, May 2017, Frontiers

    Prof. Dr. ir. Benoit Stijlemans

  33. The non-mammalian MIF superfamily

    Article • Immunobiology, March 2017, Elsevier

    Prof. Dr. ir. Benoit Stijlemans

  34. Early Immunological Responses Upon Tsetse Fly–Mediated Trypanosome Inoculation

    Article • January 2017, Elsevier

    Prof. Dr. ir. Benoit Stijlemans

  35. List of Contributors

    Article • January 2017, Elsevier

    Prof. Dr. ir. Benoit Stijlemans

  36. MIF-Mediated Hemodilution Promotes Pathogenic Anemia in Experimental African Trypanosomosis

    Article • PLoS Pathogens, September 2016, PLOS

    Prof. Dr. ir. Benoit Stijlemans

  37. Immune Evasion Strategies of Trypanosoma brucei within the Mammalian Host: Progression to Pathogenicity

    Article • Frontiers in Immunology, June 2016, Frontiers

    Prof. Dr. ir. Benoit Stijlemans

  38. Molecular Imaging with Kupffer Cell-Targeting Nanobodies for Diagnosis and Prognosis in Mouse Models of Liver Pathogenesis

    Article • Molecular Imaging and Biology, June 2016, Springer Science + Business Media

    Prof. Dr. ir. Benoit Stijlemans

  39. An Anti-proteome Nanobody Library Approach Yields a Specific Immunoassay for Trypanosoma congolense Diagnosis Targeting Glycosomal Aldolase

    Article • PLoS Neglected Tropical Diseases, February 2016, PLOS

    Prof. Dr. ir. Benoit Stijlemans

  40. The Possible Role of Staphylococcus epidermidis LPxTG Surface Protein SesC in Biofilm Formation

    Article • PLoS ONE, January 2016, PLOS

    Prof. Dr. ir. Benoit Stijlemans

  41. M-CSF and GM-CSF Receptor Signaling Differentially Regulate Monocyte Maturation and Macrophage Polarization in the Tumor Microenvironment

    Article • Cancer Research, January 2016, American Association for Cancer Research (AACR)

    Prof. Dr. ir. Benoit Stijlemans

  42. E-cadherin expression in macrophages dampens their inflammatory responsiveness in vitro, but does not modulate M2-regulated pathologies in vivo

    Article • Scientific Reports, July 2015, Nature

    Prof. Dr. ir. Benoit Stijlemans

  43. NK-, NKT- and CD8-Derived IFNγ Drives Myeloid Cell Activation and Erythrophagocytosis, Resulting in Trypanosomosis-Associated Acute Anemia

    Article • PLoS Pathogens, June 2015, PLOS

    Prof. Dr. ir. Benoit Stijlemans

  44. Macrophage dynamics are regulated by local macrophage proliferation and monocyte recruitment in injured pancreas

    Article • European Journal of Immunology, March 2015, Wiley

    Prof. Dr. ir. Benoit Stijlemans

  45. Development of a pHrodo-Based Assay for the Assessment of In Vitro and In Vivo Erythrophagocytosis during Experimental Trypanosomosis

    Article • PLoS Neglected Tropical Diseases, March 2015, PLOS

    Prof. Dr. ir. Benoit Stijlemans

  46. Monitoring liver macrophages using nanobodies targeting Vsig4: Concanavalin A induced acute hepatitis as paradigm

    Article • Immunobiology, February 2015, Elsevier

    Prof. Dr. ir. Benoit Stijlemans

  47. Murine Liver Myeloid Cell Isolation Protocol

    Article • BIO-PROTOCOL, January 2015, Bio-Protocol, LLC

    Prof. Dr. ir. Benoit Stijlemans

  48. Iron Homeostasis andTrypanosoma bruceiAssociated Immunopathogenicity Development: A Battle/Quest for Iron

    Article • BioMed Research International, January 2015, Hindawi Publishing Corporation

    Prof. Dr. ir. Benoit Stijlemans

  49. Generation of a Nanobody Targeting the Paraflagellar Rod Protein of Trypanosomes

    Article • PLoS ONE, December 2014, PLOS

    Prof. Dr. ir. Benoit Stijlemans

  50. MIF Contributes to Trypanosoma brucei Associated Immunopathogenicity Development

    Article • PLoS Pathogens, September 2014, PLOS

    Prof. Dr. ir. Benoit Stijlemans

  51. Antibody-mediated control ofTrypanosoma vivaxinfection fails in the absence of tumour necrosis factor

    Article • Parasite Immunology, May 2014, Wiley

    Prof. Dr. ir. Benoit Stijlemans

  52. Presence and regulation of insulin-regulated aminopeptidase in mouse macrophages

    Article • Journal of the Renin-Angiotensin-Aldosterone System, February 2014, SAGE Publications

    Prof. Dr. ir. Benoit Stijlemans

  53. Antibacterial activities of coagulase-negative staphylococci from bovine teat apex skin and their inhibitory effect on mastitis-related pathogens

    Article • Journal of Applied Microbiology, February 2014, Oxford University Press (OUP)

    Prof. dr. ir. Frédéric Leroy, Prof. Dr. ir. Benoit Stijlemans

  54. Low Structural Variation in the Host-Defense Peptide Repertoire of the Dwarf Clawed Frog Hymenochirus boettgeri (Pipidae)

    Article • PLoS ONE, January 2014, PLOS

    Prof. Dr. ir. Benoit Stijlemans

  55. African Trypanosomiasis as Paradigm for Involvement of the Mononuclear Phagocyte System in Pathogenicity During Parasite Infection

    Article • January 2014, Springer Science + Business Media

    Prof. Dr. ir. Benoit Stijlemans

  56. A Trypanosoma brucei Kinesin Heavy Chain Promotes Parasite Growth by Triggering Host Arginase Activity

    Article • PLoS Pathogens, October 2013, PLOS

    Prof. Dr. ir. Benoit Stijlemans

  57. Origin and Functional Diversification of an Amphibian Defense Peptide Arsenal

    Article • PLoS Genetics, August 2013, PLOS

    Prof. Dr. ir. Benoit Stijlemans

  58. Characterization of central macrophages in Anemia of Inflammation (AI): African trypanosomiasis as a model system

    Article • Frontiers in Immunology, January 2013, Frontiers

    Prof. Dr. ir. Benoit Stijlemans

  59. Correction: Affinity Is an Important Determinant of the Anti-Trypanosome Activity of Nanobodies

    Article • PLoS Neglected Tropical Diseases, December 2012, PLOS

    Prof. Dr. ir. Benoit Stijlemans

  60. 1,25-Dihydroxyvitamin D3 curtails the inflammatory and T cell stimulatory capacity of macrophages through an IL-10-dependent mechanism

    Article • Immunobiology, December 2012, Elsevier

    Prof. Dr. ir. Benoit Stijlemans

  61. Affinity Is an Important Determinant of the Anti-Trypanosome Activity of Nanobodies

    Article • PLoS Neglected Tropical Diseases, November 2012, PLOS

    Prof. Dr. ir. Benoit Stijlemans

  62. Tsetse Salivary Gland Proteins 1 and 2 Are High Affinity Nucleic Acid Binding Proteins with Residual Nuclease Activity

    Article • PLoS ONE, October 2012, PLOS

    Prof. Dr. ir. Benoit Stijlemans

  63. Vaccination with SesC Decreases Staphylococcus epidermidis Biofilm Formation

    Article • Infection and Immunity, July 2012, ASM Journals

    Prof. Dr. ir. Benoit Stijlemans

  64. Using microdialysis to analyse the passage of monovalent nanobodies through the blood–brain barrier

    Article • British Journal of Pharmacology, March 2012, Wiley

    Prof. Dr. ir. Benoit Stijlemans

  65. Expression and extracellular release of a functional anti-trypanosome Nanobody® in Sodalis glossinidius, a bacterial symbiont of the tsetse fly

    Article • Microbial Cell Factories, January 2012, Springer Science + Business Media

    Prof. Dr. ir. Benoit Stijlemans

  66. Similar inflammatory DC maturation signatures induced by TNF or Trypanosoma brucei antigens instruct default Th2-cell responses

    Article • European Journal of Immunology, November 2011, Wiley

    Prof. Dr. ir. Benoit Stijlemans

  67. IL-10 limits production of pathogenic TNF by M1 myeloid cells through induction of nuclear NF-κB p50 member inTrypanosoma congolenseinfection-resistant C57BL/6 mice

    Article • European Journal of Immunology, September 2011, Wiley

    Prof. Dr. ir. Benoit Stijlemans

  68. High Affinity Nanobodies against the Trypanosome brucei VSG Are Potent Trypanolytic Agents that Block Endocytosis

    Article • PLoS Pathogens, June 2011, PLOS

    Prof Mark C Field, Prof. Dr. ir. Benoit Stijlemans

  69. Lack of galectin-3 alleviates trypanosomiasis-associated anemia of inflammation

    Article • Immunobiology, September 2010, Elsevier

    Prof. Dr. ir. Benoit Stijlemans

  70. Tip-DC Development during Parasitic Infection Is Regulated by IL-10 and Requires CCL2/CCR2, IFN-γ and MyD88 Signaling

    Article • PLoS Pathogens, August 2010, PLOS

    Prof. Dr. ir. Benoit Stijlemans

  71. Current status of vaccination against African trypanosomiasis

    Article • Parasitology, May 2010, Cambridge University Press

    Prof. Dr. ir. Benoit Stijlemans

  72. Scrutinizing the mechanisms underlying the induction of anemia of inflammation through GPI-mediated modulation of macrophage activation in a model of African trypanosomiasis

    Article • Microbes and Infection, May 2010, Elsevier

    Prof. Dr. ir. Benoit Stijlemans

  73. The Central Role of Macrophages in Trypanosomiasis-Associated Anemia:Rationale for Therapeutical Approaches

    Article • Endocrine Metabolic & Immune Disorders - Drug Targets, March 2010, Bentham Science Publishers

    Prof. Dr. ir. Benoit Stijlemans

  74. Identification of a Parasitic Immunomodulatory Protein Triggering the Development of Suppressive M1 Macrophages during African Trypanosomiasis

    Article • The Journal of Infectious Diseases, December 2009, Oxford University Press (OUP)

    Prof. Dr. ir. Benoit Stijlemans

  75. Differentiation, activation and function of CD11b+Ly6C+ TNF/iNOS-producing dendritic cells during parasitic infection

    Article • Cytokine, October 2009, Elsevier

    Prof. Dr. ir. Benoit Stijlemans

  76. Understanding the role of monocytic cells in liver inflammation using parasite infection as a model

    Article • Immunobiology, September 2009, Elsevier

    Prof. Dr. ir. Benoit Stijlemans

  77. Inhibition of Staphylococcus epidermidis Biofilm Formation by Rabbit Polyclonal Antibodies against the SesC Protein

    Article • Infection and Immunity, June 2009, ASM Journals

    Prof. Dr. ir. Benoit Stijlemans

  78. Liver X receptors contribute to the protective immune response against Mycobacterium tuberculosis in mice

    Article • Journal of Clinical Investigation, June 2009, American Society for Clinical Investigation

    Prof. Dr. ir. Benoit Stijlemans

  79. Camelid immunoglobulins and nanobody technology

    Article • Veterinary Immunology and Immunopathology, March 2009, Elsevier

    Prof. Dr. ir. Benoit Stijlemans

  80. Role of iron homeostasis in trypanosomiasis-associated anemia

    Article • Immunobiology, November 2008, Elsevier

    Prof. Dr. ir. Benoit Stijlemans

  81. Parallel selection of multiple anti-infectome Nanobodies without access to purified antigens

    Article • Journal of Immunological Methods, January 2008, Elsevier

    Prof. Dr. ir. Benoit Stijlemans

  82. A Glycosylphosphatidylinositol-Based Treatment Alleviates Trypanosomiasis-Associated Immunopathology

    Article • The Journal of Immunology, September 2007, The American Association of Immunologists

    Prof. Dr. ir. Benoit Stijlemans

  83. African trypanosomosis: From immune escape and immunopathology to immune intervention

    Article • Veterinary Parasitology, August 2007, Elsevier

    Prof. Dr. ir. Benoit Stijlemans

  84. Traitement expérimental de la trypanosomiase africaine par le facteur trypanolytique humain combiné à un nanocorps

    Article • médecine/sciences, November 2006, EDP Sciences

    Prof. Dr. ir. Benoit Stijlemans

  85. Tsetse Fly Saliva Accelerates the Onset of Trypanosoma brucei Infection in a Mouse Model Associated with a Reduced Host Inflammatory Response

    Article • Infection and Immunity, September 2006, ASM Journals

    Prof. Dr. ir. Benoit Stijlemans

  86. Evidence for proteins involved in prophenoloxidase cascade Eisenia fetida earthworms

    Article • Journal of Comparative Physiology B, April 2006, Springer Science + Business Media

    Prof. Dr. ir. Benoit Stijlemans

  87. Experimental therapy of African trypanosomiasis with a nanobody-conjugated human trypanolytic factor

    Article • Nature Reports Stem Cells, April 2006, Nature

    Prof. Dr. ir. Benoit Stijlemans

  88. The Induction of a Type 1 Immune Response following a Trypanosoma brucei Infection Is MyD88 Dependent

    Article • The Journal of Immunology, August 2005, The American Association of Immunologists

    Prof. Dr. ir. Benoit Stijlemans

  89. Antigen Binding and Solubility Effects upon the Veneering of a Camel VHH in Framework-2 to Mimic a VH

    Article • Journal of Molecular Biology, July 2005, Elsevier

    Prof. Dr. ir. Benoit Stijlemans

  90. P75 Tumor Necrosis Factor–Receptor Shedding Occurs as a Protective Host Response during African Trypanosomiasis

    Article • The Journal of Infectious Diseases, February 2004, Oxford University Press (OUP)

    Prof. Dr. ir. Benoit Stijlemans

  91. Efficient Targeting of Conserved Cryptic Epitopes of Infectious Agents by Single Domain Antibodies

    Article • Journal of Biological Chemistry, October 2003, American Society for Biochemistry & Molecular Biology (ASBMB)

    Prof. Dr. ir. Benoit Stijlemans

  92. VSG-GPI anchors of African trypanosomes: their role in macrophage activation and induction of infection-associated immunopathology

    Article • Microbes and Infection, July 2002, Elsevier

    Prof. Dr. ir. Benoit Stijlemans

  93. Control of Experimental Trypanosoma brucei Infections Occurs Independently of Lymphotoxin-α Induction

    Article • Infection and Immunity, March 2002, ASM Journals

    Prof. Dr. ir. Benoit Stijlemans

  94. Bacterial Lipoprotein-Based Vaccines Induce Tumor Necrosis Factor-Dependent Type 1 Protective Immunity against Leishmania major

    Article • Infection and Immunity, January 2002, ASM Journals

    Prof. Dr. ir. Benoit Stijlemans

  95. Distinct Carbohydrate Recognition Domains of an Invertebrate Defense Molecule Recognize Gram-negative and Gram-positive Bacteria

    Article • Journal of Biological Chemistry, October 2001, American Society for Biochemistry & Molecular Biology (ASBMB)

    Prof. Dr. ir. Benoit Stijlemans

  96. A Conserved Flagellar Pocket Exposed High Mannose Moiety Is Used by African Trypanosomes as a Host Cytokine Binding Molecule

    Article • Journal of Biological Chemistry, September 2001, Elsevier

    Prof. Dr. ir. Benoit Stijlemans

  97. Attenuation ofTrypanosoma bruceiIs Associated with Reduced Immunosuppression and Concomitant Production of Th2 Lymphokines

    Article • The Journal of Infectious Diseases, March 2000, Oxford University Press (OUP)

    Prof. Dr. ir. Benoit Stijlemans

  98. Comparative Analysis of Antibody Responses against HSP60, Invariant Surface Glycoprotein 70, and Variant Surface Glycoprotein Reveals a Complex Antigen-Specific Pattern of Immunoglobulin Isotype Switching during Infection byTrypanosoma brucei

    Article • Infection and Immunity, February 2000, ASM Journals

    Prof. Dr. ir. Benoit Stijlemans

  99. Detection of clinically relevant antibodies pretransplant and posttransplant with PRA-STAT

    Article • Transplantation Proceedings, February 1997, Elsevier

    Prof. Dr. ir. Benoit Stijlemans