All Stories

  1. Disseminating a Free, Practical Java Tool To Interactively Generate and Edit 2D Chemical Structures

    Article • Journal of Chemical Education, April 2019, American Chemical Society (ACS)

    Associate Professor Mark J Coster

  2. Trehalose 6-phosphate phosphatases of Pseudomonas aeruginosa

    Article • The FASEB Journal, October 2018, Federation of American Societies For Experimental Biology (FASEB)

    Dr Andreas Hofmann, Associate Professor Mark J Coster

  3. Synthesis of spirocyclic orthoesters by ‘anomalous’ rhodium(ii)-catalysed intramolecular C–H insertions

    Article • Organic & Biomolecular Chemistry, January 2018, Royal Society of Chemistry

    Associate Professor Mark J Coster

  4. The design, synthesis, and anti-inflammatory evaluation of a drug-like library based on the natural product valerenic acid

    Article • Bioorganic & Medicinal Chemistry Letters, July 2017, Elsevier

    Associate Professor Mark J Coster

  5. Enzyme characteristics of pathogen-specific trehalose-6-phosphate phosphatases

    Article • Scientific Reports, May 2017, Nature

    Associate Professor Mark J Coster

  6. A bidirectional synthesis of spiroacetals via Rh(ii)-catalysed C–H insertion

    Article • Chemical Communications, January 2017, Royal Society of Chemistry

    Associate Professor Mark J Coster

  7. Dichloro-naphthoquinone as a non-classical inhibitor of the mycobacterial carbonic anhydrase Rv3588c

    Article • MedChemComm, January 2017, Royal Society of Chemistry

    Associate Professor Mark J Coster

  8. Probing function and structure of trehalose-6-phosphate phosphatases from pathogenic organisms suggests distinct molecular groupings

    Article • The FASEB Journal, November 2016, Federation of American Societies For Experimental Biology (FASEB)

    Dr Andreas Hofmann, Associate Professor Mark J Coster

  9. Panel docking of small-molecule libraries — Prospects to improve efficiency of lead compound discovery

    Article • Biotechnology Advances, November 2015, Elsevier

    Associate Professor Mark J Coster

  10. Synthesis and Antiplasmodial Evaluation of Analogues Based on the Tricyclic Core of Thiaplakortones A–D

    Article • Marine Drugs, September 2015, MDPI AG

    Associate Professor Mark J Coster

  11. Synthesis of N-alkylsulfonamides by borane–dimethyl sulfide reduction of N-acylsulfonamides

    Article • Tetrahedron Letters, April 2015, Elsevier

    Associate Professor Mark J Coster

  12. Synthesis and antimalarial evaluation of amide and urea derivatives based on the thiaplakortone A natural product scaffold

    Article • Organic & Biomolecular Chemistry, January 2015, Royal Society of Chemistry

    Associate Professor Mark J Coster

  13. Rhodium(ii)-catalysed intramolecular C–H insertion α- to oxygen: reactivity, selectivity and applications to natural product synthesis

    Article • Organic & Biomolecular Chemistry, January 2015, Royal Society of Chemistry

    Associate Professor Mark J Coster

  14. Total synthesis of (±)-nicolaioidesin B via a highly regio- and diastereoselective Diels–Alder reaction

    Article • Tetrahedron Letters, December 2014, Elsevier

    Professor Jonathan White, Associate Professor Mark J Coster

  15. Total Synthesis of Thiaplakortone A: Derivatives as Metabolically Stable Leads for the Treatment of Malaria

    Article • ACS Medicinal Chemistry Letters, February 2014, American Chemical Society (ACS)

    Associate Professor Mark J Coster

  16. Synthesis and Evaluation of Anticancer Natural Product Analogues Based on Angelmarin: Targeting the Tolerance towards Nutrient Deprivation

    Article • ChemMedChem, March 2012, Wiley

    Associate Professor Mark J Coster

  17. 3,4′-Linked bis(piperidines) related to the haliclonacyclamine class of marine alkaloids: synthesis using crossed-aldol chemistry and preliminary biological evaluations

    Article • Organic & Biomolecular Chemistry, January 2012, Royal Society of Chemistry

    Associate Professor Mark J Coster

  18. First enantioselective synthesis of methyl (+)-7-methoxyanodendroate, an antitubercular dihydrobenzofuran

    Article • Tetrahedron Letters, December 2011, Elsevier

    Associate Professor Mark J Coster

  19. Mitochondrially Targeted α-Tocopheryl Succinate Is Antiangiogenic: Potential Benefit Against Tumor Angiogenesis but Caution Against Wound Healing

    Article • Antioxidants & Redox Signaling, December 2011, Mary Ann Liebert Inc

    Associate Professor Mark J Coster, PhD Alena Pecinova

  20. A Concise Route to Dihydrobenzo[b]furans: Formal Total Synthesis of (+)-Lithospermic Acid

    Article • Organic Letters, June 2011, American Chemical Society (ACS)

    Dr Gregory Paul Savage, Associate Professor Mark J Coster

  21. Mitochondrial targeting of α-tocopheryl succinate enhances its pro-apoptotic efficacy: A new paradigm for effective cancer therapy

    Article • Free Radical Biology and Medicine, June 2011, Elsevier

    Associate Professor Mark J Coster, Jaroslav Truksa

  22. Arylation of [6,6]-spiroacetal enol ethers: reactivity and rearrangement

    Article • Tetrahedron Letters, March 2011, Elsevier

    Associate Professor Mark J Coster

  23. Mitochondrial Targeting of Vitamin E Succinate Enhances Its Pro-apoptotic and Anti-cancer Activity via Mitochondrial Complex II

    Article • Journal of Biological Chemistry, February 2011, Elsevier

    Associate Professor Mark J Coster, Jaroslav Truksa, Professor Rafael Moreno-Sanchez

  24. Targeting the Resistance of Pancreatic Cancer Cells to Nutrient Deprivation: Anti-Austerity Compounds

    Article • Current Drug Delivery, December 2010, Bentham Science Publishers

    Associate Professor Mark J Coster

  25. Oxo-bridged isomers of aza-trishomocubane sigma (σ) receptor ligands: Synthesis, in vitro binding, and molecular modeling

    Article • Bioorganic & Medicinal Chemistry Letters, January 2010, Elsevier

    Associate Professor Mark J Coster

  26. Total Synthesis of (+)-Angelmarin

    Article • The Journal of Organic Chemistry, July 2009, American Chemical Society (ACS)

    Associate Professor Mark J Coster

  27. Purinergic P2X7 receptor antagonists: Chemistry and fundamentals of biological screening

    Article • Bioorganic & Medicinal Chemistry, July 2009, Elsevier

    Associate Professor Mark J Coster

  28. Behavioural effects of a selective NMDA NR1A/2B receptor antagonist in rats with unilateral 6-OHDA+parafascicular lesions

    Article • Brain Research Bulletin, February 2009, Elsevier

    Associate Professor Mark J Coster

  29. Evaluation of behavioural effects of a selective NMDA NR1A/2B receptor antagonist in the unilateral 6-OHDA lesion rat model

    Article • Brain Research Bulletin, February 2009, Elsevier

    Associate Professor Mark J Coster

  30. Cubyl amides: Novel P2X7 receptor antagonists

    Article • Bioorganic & Medicinal Chemistry Letters, July 2008, Elsevier

    Associate Professor Mark J Coster

  31. Synthesis and In-Vivo Evaluation of [11C]p-PVP-MEMA as a PET Radioligand for Imaging Nicotinic Receptors

    Article • Australian Journal of Chemistry, January 2008, CSIRO Publishing

    Associate Professor Mark J Coster

  32. Asymmetric aldol reaction using boron enolates

    Article • Nature Protocols, October 2007, Nature

    Associate Professor Mark J Coster

  33. Trishomocubanes: Novel σ ligands modulate cocaine-induced behavioural effects

    Article • European Journal of Pharmacology, January 2007, Elsevier

    Professor Steven Richard Meikle, Associate Professor Mark J Coster

  34. Reversibility in the boron-mediated ketone–ketone aldol reaction

    Article • Chemical Communications, January 2007, Royal Society of Chemistry

    Associate Professor Mark J Coster

  35. (1R,2S,3R,6S,7R,8S)-Tricyclo[6.2.1.02,7]undeca-4,9-diene-3,6-diol

    Article • Acta Crystallographica Section E Structure Reports Online, December 2006, International Union of Crystallography

    Associate Professor Mark J Coster

  36. Total Synthesis of Spongistatin 1 (Altohyrtin A): A Tale of Ten Aldols

    Article • ChemInform, September 2005, Wiley

    Associate Professor Mark J Coster

  37. The boron-mediated ketone–ketone aldol reaction

    Article • Tetrahedron Letters, February 2005, Elsevier

    Associate Professor Mark J Coster

  38. The stereocontrolled total synthesis of altohyrtin A/spongistatin 1: the CD-spiroacetal segment

    Article • Organic & Biomolecular Chemistry, January 2005, Royal Society of Chemistry

    Associate Professor Mark J Coster

  39. The stereocontrolled total synthesis of altohyrtin A/spongistatin 1: the AB-spiroacetal segment

    Article • Organic & Biomolecular Chemistry, January 2005, Royal Society of Chemistry

    Associate Professor Mark J Coster

  40. The stereocontrolled total synthesis of altohyrtin A/spongistatin 1: fragment couplings, completion of the synthesis, analogue generation and biological evaluation

    Article • Organic & Biomolecular Chemistry, January 2005, Royal Society of Chemistry

    Associate Professor Mark J Coster

  41. Synthesis and biological evaluation of spongistatin/altohyrtin analogues: E-ring dehydration and C46 side-chain truncationElectronic supplementary information (ESI) available: spectroscopic data for compounds 2 and 3. See http://www.rsc.org/suppdata/cc...

    Article • Chemical Communications, January 2003, Royal Society of Chemistry

    Associate Professor Mark J Coster

  42. A Total Synthesis of the Styryllactone (+)-Goniodiol from Naphthalene

    Article • Australian Journal of Chemistry, January 2003, CSIRO Publishing

    Associate Professor Mark J Coster

  43. CP-225,917 and CP-263,114 Synthesis Support Studies: Testing a Radical Cyclization Strategy for Installation of the Side-Chains

    Article • Australian Journal of Chemistry, January 2003, CSIRO Publishing

    Associate Professor Mark J Coster

  44. Selective Cleavage ofN-Benzyl-Protected Secondary Amines by Triphosgene

    Article • The Journal of Organic Chemistry, January 2003, American Chemical Society (ACS)

    Associate Professor Mark J Coster

  45. Medium Ring Ethers by Ring Expansion−Ring Contraction:  Synthesis of Lauthisan

    Article • Organic Letters, September 2002, American Chemical Society (ACS)

    Associate Professor Mark J Coster

  46. A chemoenzymatic synthesis of the styryllactone (+)-goniodiol from naphthalene

    Article • Journal of the Chemical Society Perkin Transactions 1, June 2002, Royal Society of Chemistry

    Associate Professor Mark J Coster

  47. Stereocontrolled Total Synthesis of (+)-Altohyrtin A/Spongistatin 1 Financial support was provided by the EPSRC (GR/L41646), Cambridge Commonwealth Trust (Scholarship to M.J.C.), EC (Marie Curie Postdoctoral Fellowship to J.L.A.), DFG (Postdoctoral Fel...

    Article • Angewandte Chemie International Edition, November 2001, Wiley

    Associate Professor Mark J Coster