All Stories

  1. Cytochrome c Oxidase Subunit 4 Isoform Exchange Results in Modulation of Oxygen Affinity

    Article • Cells, February 2020, MDPI AG

    PhD Alena Pecinova

  2. Biochemical thresholds for pathological presentation of ATP synthase deficiencies

    Article • Biochemical and Biophysical Research Communications, January 2020, Elsevier

    PhD Alena Pecinova

  3. Mitochondrial targets of metformin—Are they physiologically relevant?

    Article • BioFactors, July 2019, Wiley

    PhD Alena Pecinova

  4. Pleiotropic Effects of Biguanides on Mitochondrial Reactive Oxygen Species Production

    Article • Oxidative Medicine and Cellular Longevity, January 2017, Hindawi Publishing Corporation

    PhD Alena Pecinova

  5. Mitochondrial Targeting of Metformin Enhances Its Activity against Pancreatic Cancer

    Article • Molecular Cancer Therapeutics, October 2016, American Association for Cancer Research (AACR)

    PhD Alena Pecinova

  6. Pharmacological inhibition of fatty-acid oxidation synergistically enhances the effect of l-asparaginase in childhood ALL cells

    Article • Leukemia, August 2015, Springer Science + Business Media

    PhD Alena Pecinova

  7. Noninvasive diagnostics of mitochondrial disorders in isolated lymphocytes with high resolution respirometry

    Article • BBA Clinical, December 2014, Elsevier

    PhD Alena Pecinova

  8. ROS production in brown adipose tissue mitochondria: The question of UCP1-dependence

    Article • Biochimica et Biophysica Acta (BBA) - Bioenergetics, December 2014, Elsevier

    PhD Alena Pecinova

  9. Cytochrome c oxidase subunit 4 isoform 2-knockout mice show reduced enzyme activity, airway hyporeactivity, and lung pathology

    Article • The FASEB Journal, June 2012, Federation of American Societies For Experimental Biology (FASEB)

    PhD Alena Pecinova

  10. Mice deleted for heart-type cytochrome c oxidase subunit 7a1 develop dilated cardiomyopathy

    Article • Mitochondrion, March 2012, Elsevier

    PhD Alena Pecinova

  11. Mitochondrially Targeted α-Tocopheryl Succinate Is Antiangiogenic: Potential Benefit Against Tumor Angiogenesis but Caution Against Wound Healing

    Article • Antioxidants & Redox Signaling, December 2011, Mary Ann Liebert Inc

    Associate Professor Mark J Coster, PhD Alena Pecinova

  12. Evaluation of basic mitochondrial functions using rat tissue homogenates

    Article • Mitochondrion, September 2011, Elsevier

    PhD Alena Pecinova

  13. Phosphomimetic Substitution of CytochromecTyrosine 48 Decreases Respiration and Binding to Cardiolipin and Abolishes Ability to Trigger Downstream Caspase Activation

    Article • Biochemistry, August 2010, American Chemical Society (ACS)

    PhD Alena Pecinova

  14. Impaired mitochondrial energetic in patients harbouring SURF1 mutations is caused by uncoupling of cytochrome c oxidase

    Article • Biochimica et Biophysica Acta (BBA) - Bioenergetics, July 2010, Elsevier

    PhD Alena Pecinova

  15. Increased oxidative stress in fibroblasts from patients with ATP synthase deficiency

    Article • Biochimica et Biophysica Acta (BBA) - Bioenergetics, July 2010, Elsevier

    PhD Alena Pecinova

  16. Regulation of mitochondrial respiration and apoptosis through phosphorylation of cytochrome c

    Article • Biochimica et Biophysica Acta (BBA) - Bioenergetics, July 2010, Elsevier

    PhD Alena Pecinova

  17. Mitochondrial ATP synthase deficiency due to a mutation in the ATP5E gene for the F1   subunit

    Article • Human Molecular Genetics, June 2010, Oxford University Press (OUP)

    PhD Alena Pecinova

  18. A suggested role for mitochondria in Noonan syndrome

    Article • Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, February 2010, Elsevier

    PhD Alena Pecinova

  19. Mitochondrial dysfunction in a neural cell model of spinal muscular atrophy

    Article • Journal of Neuroscience Research, September 2009, Wiley

    PhD Alena Pecinova

  20. Chapter 11 Isolation of Regulatory‐Competent, Phosphorylated Cytochrome c Oxidase

    Article • January 2009, Elsevier

    PhD Alena Pecinova

  21. High efficiency of ROS production by glycerophosphate dehydrogenase in mammalian mitochondria

    Article • Archives of Biochemistry and Biophysics, January 2009, Elsevier

    PhD Alena Pecinova

  22. Regulation of oxidative phosphorylation, the mitochondrial membrane potential, and their role in human disease

    Article • Journal of Bioenergetics and Biomembranes, October 2008, Springer Science + Business Media

    PhD Alena Pecinova

  23. HIF and reactive oxygen species regulate oxidative phosphorylation in cancer

    Article • Carcinogenesis, May 2008, Oxford University Press (OUP)

    PhD Alena Pecinova

  24. Direct linkage of mitochondrial genome variation to risk factors for type 2 diabetes in conplastic strains

    Article • Genome Research, July 2007, Cold Spring Harbor Laboratory Press

    PhD Alena Pecinova

  25. Respiratory chain components involved in the glycerophosphate dehydrogenase-dependent ROS production by brown adipose tissue mitochondria

    Article • Biochimica et Biophysica Acta (BBA) - Bioenergetics, July 2007, Elsevier

    PhD Alena Pecinova

  26. Mitochondrial complex I inhibition in cerebral cortex of immature rats following homocysteic acid-induced seizures

    Article • Experimental Neurology, April 2007, Elsevier

    PhD Alena Pecinova

  27. Mitochondrial diseases and genetic defects of ATP synthase

    Article • Biochimica et Biophysica Acta (BBA) - Bioenergetics, September 2006, Elsevier

    PhD Alena Pecinova

  28. Two components in pathogenic mechanism of mitochondrial ATPase deficiency: Energy deprivation and ROS production

    Article • Experimental Gerontology, July 2006, Elsevier

    PhD Alena Pecinova

  29. Evaluation of mitochondrial membrane potential using a computerized device with a tetraphenylphosphonium-selective electrode

    Article • Analytical Biochemistry, June 2006, Elsevier

    PhD Alena Pecinova

  30. Inhibition of cytochrome c oxidase subunit 4 precursor processing by the hypoxia mimic cobalt chloride

    Article • Biochemical and Biophysical Research Communications, June 2006, Elsevier

    PhD Alena Pecinova

  31. Flow-cytometric monitoring of mitochondrial depolarisation: from fluorescence intensities to millivolts

    Article • Journal of Photochemistry and Photobiology B Biology, February 2005, Elsevier

    PhD Alena Pecinova

  32. Diminished synthesis of subunit a (ATP6) and altered function of ATP synthase and cytochromecoxidase due to the mtDNA 2 bp microdeletion of TA at positions 9205 and 9206

    Article • Biochemical Journal, November 2004, Portland Press Ltd.

    PhD Alena Pecinova

  33. A new role for the von Hippel-Lindau tumor suppressor protein: stimulation of mitochondrial oxidative phosphorylation complex biogenesis

    Article • Carcinogenesis, September 2004, Oxford University Press (OUP)

    PhD Alena Pecinova

  34. Mitochondrial diseases and ATPase defects of nuclear origin

    Article • Biochimica et Biophysica Acta (BBA) - Bioenergetics, July 2004, Elsevier

    PhD Alena Pecinova

  35. GUG is an efficient initiation codon to translate the human mitochondrial ATP6 gene

    Article • Biochemical and Biophysical Research Communications, January 2004, Elsevier

    PhD Alena Pecinova

  36. Mitochondrial Membrane Potential and ATP Production in Primary Disorders of ATP Synthase

    Article • Toxicology Mechanisms and Methods, January 2004, Taylor & Francis

    PhD Alena Pecinova

  37. Functional alteration of cytochrome c oxidase by SURF1 mutations in Leigh syndrome

    Article • Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, September 2003, Elsevier

    PhD Alena Pecinova