All Stories

  1. An allosteric inhibitor of RhoGAP class-IX myosins suppresses the metastatic features of cancer cells

    Article • Nature Communications, November 2024, Springer Science + Business Media

    Dr Manuel H Taft

  2. Crystal structures of cables formed by the acetylated and unacetylated forms of the Schizosaccharomyces pombe tropomyosin orthologue TpmCdc8

    Article • Journal of Biological Chemistry, October 2024, Elsevier

    Dr Manuel H Taft

  3. Editorial: Unconventional myosins in motile and contractile functions: fifty years on the stage

    Article • Frontiers in Physiology, June 2024, Frontiers

    Dr Manuel H Taft

  4. Biochemical characterization of cardiac α‐actin mutations A21V and D26N implicated in hypertrophic cardiomyopathy

    Article • Cytoskeleton, March 2024, Wiley

    Dr Manuel H Taft

  5. The non-muscle actinopathy-associated mutation E334Q in cytoskeletal γ-actin perturbs interaction of actin filaments with myosin and ADF/cofilin family proteins

    Article • eLife, March 2024, eLife

    Dr Manuel H Taft

  6. The non–muscle actinopathy–associated mutation E334Q in cytoskeletal γ– actin perturbs interaction of actin filaments with myosin and ADF/cofilin family proteins

    Article • February 2024, eLife

    Dr Manuel H Taft

  7. The non–muscle actinopathy–associated mutation E334Q in cytoskeletal γ–actin perturbs interaction of actin filaments with myosin and ADF/cofilin family proteins

    Article • December 2023, eLife

    Dr Manuel H Taft

  8. The non–muscle actinopathy–associated mutation E334Q in cytoskeletal γ–actin perturbs interaction of actin filaments with myosin and ADF/cofilin family proteins

    Article • December 2023, eLife

    Dr Manuel H Taft

  9. Extending the enzymatic toolbox for heparosan polymerization, depolymerization, and detection

    Article • Carbohydrate Polymers, November 2023, Elsevier

    Dr Manuel H Taft

  10. The non-muscle actinopathy-associated mutation E334Q in cytoskeletal gamma-actin perturbs interaction of actin filaments with myosin and ADF/cofilin family proteins

    Article • September 2023, Cold Spring Harbor Laboratory Press

    Dr Manuel H Taft

  11. Distinct actin–tropomyosin cofilament populations drive the functional diversification of cytoskeletal myosin motor complexes

    Article • iScience, July 2022, Elsevier

    Dr Manuel H Taft, Professor Dietmar J. Manstein

  12. Meteorin-like promotes heart repair through endothelial KIT receptor tyrosine kinase

    Article • Science, June 2022, American Association for the Advancement of Science

    Dr Manuel H Taft

  13. Frameshift mutation S368fs in the gene encoding cytoskeletal β-actin leads to ACTB-associated syndromic thrombocytopenia by impairing actin dynamics

    Article • European Journal of Cell Biology, April 2022, Elsevier

    Dr Manuel H Taft, Professor Dietmar J. Manstein

  14. Assessment of the Contribution of a Thermodynamic and Mechanical Destabilization of Myosin-Binding Protein C Domain C2 to the Pathomechanism of Hypertrophic Cardiomyopathy-Causing Double Mutation MYBPC3Δ25bp/D389V

    Article • International Journal of Molecular Sciences, November 2021, MDPI AG

    Dr Manuel H Taft, Professor Dietmar J. Manstein

  15. Assessment of the Contribution of a Thermodynamic and Mechanical Destabilization of Myosin–Binding Protein C Domain C2 to the Pathomechanism of Hypertrophic Cardiomyopathy–causing Double Mutation MYBPC3Δ25bp/D389V

    Article • October 2021, MDPI AG

    Dr Manuel H Taft, Professor Dietmar J. Manstein

  16. Structural and Biochemical Characterization of a Dye-Decolorizing Peroxidase from Dictyostelium discoideum

    Article • International Journal of Molecular Sciences, June 2021, MDPI AG

    Professor Dietmar J. Manstein, Dr Manuel H Taft

  17. Structural and Biochemical Characterization of a Dye Decolorizing Peroxidase from Dictyostelium discoideum

    Article • June 2021, MDPI AG

    Dr Manuel H Taft, Professor Dietmar J. Manstein

  18. Allosteric modulation of cardiac myosin mechanics and kinetics by the conjugated omega‐7,9 trans‐fat rumenic acid

    Article • The Journal of Physiology, June 2021, Wiley

    Professor Dietmar J. Manstein, Dr Manuel H Taft

  19. Structural and Biochemical Characterization of a Dye Decolorizing Peroxidase from Dictyostelium discoideum

    Article • May 2021, MDPI AG

    Dr Manuel H Taft, Professor Dietmar J. Manstein

  20. Muscle myosin performance measured with a synthetic nanomachine reveals a class‐specific Ca 2+ ‐sensitivity of the frog myosin II isoform

    Article • The Journal of Physiology, January 2021, Wiley

    Dr Manuel H Taft, Professor Dietmar J. Manstein

  21. Mechanochemical properties of human myosin 1C are modulated by isoform-specific differences in the N-terminal extension

    Article • Journal of Biological Chemistry, November 2020, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Manuel H Taft, Professor Dietmar J. Manstein

  22. Myosin-18B Regulates Higher-Order Organization of the Cardiac Sarcomere through Thin Filament Cross-Linking and Thick Filament Dynamics

    Article • Cell Reports, September 2020, Elsevier

    Dr Manuel H Taft, Professor Dietmar J. Manstein

  23. Undefeated—Changing the phenamacril scaffold is not enough to beat resistant Fusarium

    Article • PLoS ONE, June 2020, PLOS

    Dr Manuel H Taft, Professor Dietmar J. Manstein

  24. Myosin XVIII

    Article • January 2020, Springer Science + Business Media

    Dr Manuel H Taft

  25. C-Mannosylation supports folding and enhances stability of thrombospondin repeats

    Article • eLife, December 2019, eLife

    Dr Manuel H Taft

  26. Phenamacril is a reversible and non-competitive inhibitor of Fusarium class I myosin

    Article • Journal of Biological Chemistry, November 2018, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Dietmar J. Manstein, Dr Manuel H Taft

  27. Author Correction: Variants in exons 5 and 6 of ACTB cause syndromic thrombocytopenia

    Article • Nature Communications, November 2018, Springer Science + Business Media

    Dr Manuel H Taft, Professor Dietmar J. Manstein

  28. Variants in exons 5 and 6 of ACTB cause syndromic thrombocytopenia

    Article • Nature Communications, October 2018, Springer Science + Business Media

    Professor Dietmar J. Manstein, Dr Manuel H Taft

  29. Co-polymers of Actin and Tropomyosin Account for a Major Fraction of the Human Actin Cytoskeleton

    Article • Current Biology, July 2018, Elsevier

    Professor Dietmar J. Manstein, Dr Manuel H Taft

  30. Thrombocytopenia Microcephaly Syndrome - a novel phenotype associated with ACTB mutations

    Article • April 2018, Cold Spring Harbor Laboratory Press

    Professor Dietmar J. Manstein, Dr Manuel H Taft

  31. Three mammalian tropomyosin isoforms have different regulatory effects on nonmuscle myosin-2B and filamentous β-actinin vitro

    Article • Journal of Biological Chemistry, November 2017, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Dietmar J. Manstein, Dr Manuel H Taft

  32. Pink-beam serial crystallography

    Article • Nature Communications, November 2017, Springer Science + Business Media

    Professor Henry N Chapman, Professor Dietmar J. Manstein, Dr Manuel H Taft

  33. N-terminal splicing extensions of the humanMYO1Cgene fine-tune the kinetics of the three full-length myosin IC isoforms

    Article • Journal of Biological Chemistry, September 2017, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Dietmar J. Manstein, Dr Manuel H Taft

  34. The Conserved Lysine-265 Allosterically Modulates Nucleotide- and Actin-binding Site Coupling in Myosin-2

    Article • Scientific Reports, August 2017, Springer Science + Business Media

    Dr Manuel H Taft

  35. Low-background pink-beam serial crystallography

    Article • Acta Crystallographica Section A Foundations and Advances, May 2017, International Union of Crystallography

    Dr Manuel H Taft

  36. Load-dependent modulation of non-muscle myosin-2A function by tropomyosin 4.2

    Article • Scientific Reports, February 2016, Nature

    Professor Dietmar J. Manstein, Dr Manuel H Taft

  37. Arachidonic Acid Directly Binds and Activates Beta-Cardiac Myosin in the Regulated Cardiac Actomyosin Complex

    Article • Biophysical Journal, February 2016, Elsevier

    Professor Dietmar J. Manstein, Dr Manuel H Taft

  38. GTPase domain driven dimerization of SEPT7 is dispensable for the critical role of septins in fibroblast cytokinesis

    Article • Scientific Reports, January 2016, Springer Science + Business Media

    Manoj B Menon, Dr Manuel H Taft

  39. Context-Dependent Sensitivity to Mutations Disrupting the Structural Integrity of Individual EGF Repeats in the Mouse Notch Ligand DLL1

    Article • Genetics, January 2016, Genetics Society of America

    Dr Manuel H Taft

  40. Crystal Structure of Human Myosin 1c—The Motor in GLUT4 Exocytosis: Implications for Ca2+ Regulation and 14-3-3 Binding

    Article • Journal of Molecular Biology, May 2014, Elsevier

    Professor Dietmar J. Manstein, Dr Manuel H Taft

  41. Crystal structure of human Myosin 1c in complex with calmodulin in the pre-power stroke state

    Article • March 2014, Protein Data Bank, Rutgers University

    Dr Manuel H Taft

  42. Small molecule-mediated refolding and activation of myosin motor function

    Article • eLife, February 2014, eLife

    Professor Dietmar J. Manstein, Dr Manuel H Taft

  43. Human Myosin-18B - A Versatile Actin Binding Protein

    Article • Biophysical Journal, January 2014, Elsevier

    Professor Dietmar J. Manstein, Dr Manuel H Taft

  44. Structural and Functional Characterization of Nonmuscle Myosin-2B in the Presence of Regulated Actin Filaments

    Article • Biophysical Journal, January 2014, Elsevier

    Professor Dietmar J. Manstein, Dr Manuel H Taft

  45. Structural Basis of Myosin 1C Ca2+ Regulation

    Article • Biophysical Journal, January 2014, Elsevier

    Professor Dietmar J. Manstein, Dr Manuel H Taft

  46. Unconventional Human Myosin-18A

    Article • Journal of Biological Chemistry, August 2013, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Manuel H Taft, Professor Dietmar J. Manstein

  47. Distinct Functional Interactions between Actin Isoforms and Nonsarcomeric Myosins

    Article • PLoS ONE, July 2013, PLOS

    Professor Dietmar J. Manstein, Dr Manuel H Taft

  48. Mechanisms of Mechanochemical Coupling in Low and High Duty Ratio Myosins

    Article • Biophysical Journal, January 2013, Elsevier

    Dr Manuel H Taft

  49. EMD57033 Acts as a Pharmacological Chaperone Stabilizing and Activating Myosin Motor Activity

    Article • Biophysical Journal, January 2012, Elsevier

    Professor Dietmar J. Manstein, Dr Manuel H Taft

  50. Functional Characterization of Human Myosin-18A and its Interaction Partners

    Article • Biophysical Journal, January 2012, Elsevier

    Professor Dietmar J. Manstein, Dr Manuel H Taft

  51. Myosin-1C associates with microtubules and stabilizes the mitotic spindle during cell division

    Article • Journal of Cell Science, June 2011, The Company of Biologists

    Dr Manuel H Taft

  52. Mechanism and Specificity of Pentachloropseudilin-mediated Inhibition of Myosin Motor Activity

    Article • Journal of Biological Chemistry, June 2011, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Manuel H Taft, Professor Dietmar J. Manstein

  53. Phalloidin perturbs the interaction of human non-muscle myosin isoforms 2A and 2C1 with F-actin

    Article • FEBS Letters, February 2011, Wiley

    Professor Dietmar J. Manstein, Dr Manuel H Taft

  54. The structural and mechanistic basis of allosteric modulation of myosin motor activity by pharmacological agents

    Article • Acta Crystallographica Section A Foundations of Crystallography, August 2009, International Union of Crystallography

    Professor Dietmar J. Manstein, Dr Manuel H Taft

  55. The mechanism of pentabromopseudilin inhibition of myosin motor activity

    Article • Nature Structural & Molecular Biology, January 2009, Springer Science + Business Media

    Professor Dietmar J. Manstein, Dr Manuel H Taft

  56. DictyosteliumMyosin-5b Is a Conditional Processive Motor

    Article • Journal of Biological Chemistry, July 2008, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Manuel H Taft, Professor Dietmar J. Manstein