All Stories

  1. Polymer nanotherapeutics with the controlled release of acetylsalicylic acid and its derivatives inhibiting cyclooxygenase isoforms and reducing the production of pro-inflammatory mediators
  2. Unlocking the Puzzle: Investigating the Role of Interleukin 17 Genetic Polymorphisms, Circulating Lymphocytes, and Serum Levels in Venezuelan Women with Recurrent Pregnancy Loss
  3. Interleukin-receptor antagonist and tumour necrosis factor inhibitors for the primary and secondary prevention of atherosclerotic cardiovascular diseases
  4. Microbiota and Recurrent Pregnancy Loss (RPL); More than a Simple Connection
  5. Role of Micronutrients in the Response to SARS-CoV-2 Infection in Pediatric Patients
  6. Lck Function and Modulation: Immune Cytotoxic Response and Tumor Treatment More Than a Simple Event
  7. Inflammation, Autoimmunity and Neurodegenerative Diseases, Therapeutics and Beyond
  8. Genetic polymorphism in primary, recurrent pregnancy loss
  9. Antineoplastics for treating Alzheimer's disease and dementia: Evidence from preclinical and observational studies
  10. Isoform-Directed Control of c-Myc Functions: Understanding the Balance from Proliferation to Growth Arrest
  11. Synthesis, Antimalarial, Antileishmanial, and Cytotoxicity Activities and Preliminary In Silico ADMET Studies of 2-(7-Chloroquinolin-4-ylamino)ethyl Benzoate Derivatives
  12. CRISPR/Cas9 bioluminescence-based assay for monitoring CFTR trafficking to the plasma membrane
  13. A Synopsis of Hepatitis C Virus Treatments and Future Perspectives
  14. SARS-CoV-2 Infection in Venezuelan Pediatric Patients—A Single Center Prospective Observational Study
  15. Autoimmunity and Immunodeficiency in Severe SARS-CoV-2 Infection and Prolonged COVID-19
  16. Novel 7-Chloro-(4-thioalkylquinoline) Derivatives: Synthesis and Antiproliferative Activity through Inducing Apoptosis and DNA/RNA Damage
  17. Innate Immune Response in Hypertension
  18. Synthesis, Leishmanicidal, Trypanocidal, Antiproliferative Assay and Apoptotic Induction of (2-Phenoxypyridin-3-yl)naphthalene-1(2H)-one Derivatives
  19. Effect of tetrahydroquinoline derivatives on the intracellular Ca2+ homeostasis in breast cancer cells (MCF-7) and its relationship with apoptosis.
  20. Metabolic Reprogramming in Cancer Cells: Emerging Molecular Mechanisms and Novel Therapeutic Approaches
  21. Molecular Mechanisms of Chloroquine and Hydroxychloroquine use in Cancer Therapy
  22. Caracasine, an ent-kaurane diterpene with proapoptotic and pro-differentiator activity in human leukaemia cell lines
  23. Cellular Senescence: Molecular Targets, Biomarkers, and Senolytic Drugs
  24. Estudio piloto: análisis y detección de anticuerpos IgM e IgG específicos contra el dominio de unión al receptor de la proteína de la espiga del SARS-CoV-2
  25. Specialized Proresolving Lipid Mediators: A Potential Therapeutic Target for Atherosclerosis
  26. One-Step Synthesis of Nanoliposomal Copper Diethyldithiocarbamate and Its Assessment for Cancer Therapy
  27. Effect of Glucocorticosteroids in Diamond-Blackfan Anaemia: Maybe Not as Elusive as It Seems
  28. Overview of Memory NK Cells in Viral Infections: Possible Role in SARS-CoV-2 Infection
  29. Kauranes as Anti-inflammatory and Immunomodulatory Agents: An Overview of In Vitro and In Vivo Effects
  30. The YAP/TAZ Signaling Pathway in the Tumor Microenvironment and Carcinogenesis: Current Knowledge and Therapeutic Promises
  31. Assessment of Inflammatory Response and its Resolution in Viral Infection and Rheumatoid Arthritis
  32. Potential Role of Bioactive Lipids in Rheumatoid Arthritis
  33. Importancia de la respuesta inmune celular adaptativa en la infección por SARS-CoV-2
  34. Specialized Pro-Resolving Lipid Mediators: The Future of Chronic Pain Therapy?
  35. Tau secretion and propagation: Perspectives for potential preventive interventions in Alzheimer's disease and other tauopathies
  36. A Brief Analysis of Tissue-Resident NK Cells in Pregnancy and Endometrial Diseases: The Importance of Pharmacologic Modulation
  37. Editorial: Quo Vadis Lipid Mediators – Lipid Mediators Implication in Inflammation and Chronic Inflammatory Diseases
  38. Coronavirus infection: An immunologists' perspective
  39. Synthesis and antimalarial and anticancer evaluation of 7‐chlorquinoline‐4‐thiazoleacetic derivatives containing aryl hydrazide moieties
  40. CFTR Correctors and Antioxidants Partially Normalize Lipid Imbalance but not Abnormal Basal Inflammatory Cytokine Profile in CF Bronchial Epithelial Cells
  41. Quo Vadis Lipid Mediators – Lipid Mediators Implication in Inflammation and Chronic Inflammatory Diseases
  42. Subpoblaciones linfocitarias de pacientes venezolanos infectados con SARS-CoV-2
  43. Importance of miRNA in SARS-CoV2 infection
  44. Functionally Relevant Differences in Plasma Fatty Acid Composition and Expression of Cytotoxic and Inhibitory NK Cell Receptors between Healthy Young and Healthy Elder Adults
  45. Small Natural and Synthetic Molecules for Therapeutic Use
  46. A brief overview of cancer research in the elderly population
  47. The role of essential fatty acids in cystic fibrosis and normalizing effect of fenretinide
  48. Age-Dependent Progression in Lung Pathophysiology can be Prevented by Restoring Fatty Acid and Ceramide Imbalance in Cystic Fibrosis
  49. Treatment of allergic asthma with Fenretinide formulation (LAU-7b) downregulates Ormdl3 expression and normalizes ceramides imbalance
  50. Fenretinide favorably affects mucins (MUC5AC/MUC5B) and fatty acid imbalance in a manner mimicking CFTR-induced correction
  51. Synthesis and biological activity of 2-[2-(7-chloroquinolin-4-ylthio)-4-methylthiazol-5-yl]-N-phenylacetamide derivatives as antimalarial and cytotoxic agents
  52. Effect of fenretidine on murine asthma model
  53. Pharmacologic Modulation of the Immune Response Against Tumours in the Elderly
  54. New structures as anti malarials and anti cancer drugs
  55. Caracasine acid is a seco kaurene purified from Croton caracasana
  56. Reviw on the importance of long chain fatty acids
  57. Effects of flavonoids and Its Derivatives on Immune Cell Responses
  58. Synthesis, antimalarial, antiproliferative, and apoptotic activities of benzimidazole-5-carboxamide derivatives
  59. Cardiorespiratory responses, nitric oxide production and inflammatory factors in patients with myocardial infarction after rehabilitation
  60. Importance of zona pellucida binding protgein in inflammation
  61. Anti malarial and anti cancer compound
  62. Fenretinide differentially modulates the levels of long- and very long-chain ceramides by downregulating Cers5 enzyme: evidence from bench to bedside
  63. Proteomic profiling reveals DNA damage, nucleolar and ribosomal stress are the main responses to oxaliplatin treatment in cancer cells
  64. A Review of Clinical Trials of Belimumab in the Management of Systemic Lupus Erythematosus
  65. Editorial of immunomodulation issue
  66. Correction of lung inflammation in a F508del CFTR murine cystic fibrosis model by the sphingosine-1-phosphate lyase inhibitor LX2931
  67. Sphingosine inhibits the sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA) activity
  68. Inflammatory gene polymorphisms in asthma and chronic obstructive pulmonary disease in Venezuela
  69. Peptide Vaccines for Cancer Therapy
  70. Editorial (Thematic Issue: Vaccines)
  71. Vaccine Therapy Update for Pregnant, Immunocompromised, and Chronic Diseases Patients
  72. Lycopene improves the distorted ratio between AA/DHA in the seminal plasma of infertile males and increases the likelihood of successful pregnancy
  73. New treatment for asthma
  74. An Overview of Hepatitis C Vaccines
  75. This review refers to the different approaches for vaccine therapy in HIV infection
  76. Importance in unsaturated fatty acids in zoonotic infection
  77. Candidate Markers Associated with the Probability of Future Pulmonary Exacerbations in Cystic Fibrosis Patients
  78. Metabolic Syndrome and Asthma
  79. Surfactant Protein D in Chornic Obstructive Pulmonary Disease (COPD)
  80. Fenretinide Corrects the Imbalance between Omega-6 to Omega-3 Polyunsaturated Fatty Acids and Inhibits Macrophage Inflammatory Mediators via the ERK Pathway
  81. The review focus on the different adjuvants and delivery systems used for diffetent vaccines
  82. Recent Patents in Autophagy and Immune Response
  83. Nitric oxide synthase and its relation to PKC activation
  84. Gene-Metabolite Expression in Blood Can Discriminate Allergen-Induced Isolated Early from Dual Asthmatic Responses
  85. Effect of lycopene administration in cystic fibrosis patients
  86. Biomarkers in Asthma and COPD
  87. Lipid profile analysis in spinal trauma patients shows severe distortion of AA/DHA after injury
  88. Beta 2 adrenergic receptor polymorphisms, at codons 16 and 27, and bronchodilator responses in adult venezuelan asthmatic patients
  89. Cytotoxic effects of fisturalin-3 and 11-deoxyfisturalin-3 on jurkat and u937 cell lines
  90. Perspectives of New Therapies for Endometriosis
  91. 336 The Leukotriene C4 Synthase (A-444C) Promoter Polymorphism in Venezuelan Individuals with Asthma
  92. Role of Beta2 Agonists in Respiratory Medicine with Particular Attention to Novel Patents and Effects on Endocrine System and Immune Response
  93. Inhibitors of Phosphoinositol 3 Kinase and NFκB for the Treatment of Chronic Obstructive Pulmonary Disease
  94. The marine sponge toxin agelasine B increases the intracellular Ca2+ concentration and induces apoptosis in human breast cancer cells (MCF-7)
  95. New pharmacological treatments for patients with chronic obstructive pumonary disease (copd)
  96. Specific activation of human neutrophils by scorpion venom: A flow cytometry assessment
  97. Atherosclerosis risk in SLE is not dependent on macrophage uptake of ox-LDL
  98. Ceramide in Cystic Fibrosis: A Potential New Target for Therapeutic Intervention
  99. Pharmacological Properties of Thalidomide and its Analogues
  100. Fenretinide Promotes Functional Recovery and Tissue Protection after Spinal Cord Contusion Injury in Mice
  101. CD16 cross-linking induces increased expression of CD56 and production of IL-12 in peripheral NK cells
  102. Increased lipid peroxidation and abnormal fatty acid profiles in seminal and blood plasma of normozoospermic males from infertile couples
  103. Cystic Fibrosis Fatty Acid Imbalance Is Linked to Ceramide Deficiency and Corrected by Fenretinide
  104. Pharmacological Modulation of Th17
  105. Serum adipokine levels in patients with systemic lupus erythematosus
  106. Total and biologically active CD154 in patients with SLE
  107. Decreased transcription, expression and function of low-density lipoprotein receptor in leukocytes from patients with systemic lupus erythematosus
  108. Fenretinide prevents the development of osteoporosis in Cftr-KO mice
  109. Abnalysis of the effect of smoking in muscle
  110. Possible role of NFĸB in the embryonic vascular remodeling and the endothelial-mesenchymal transition process
  111. Fenretinide Corrects Newly Found Ceramide Deficiency in Cystic Fibrosis
  112. Nitric Oxide Metabolites and Nitrotyrosine in Asthma and COPD
  113. Toll-Like Receptors, Cytokines and the Immunotherapeutics of Asthma
  114. New Frontiers in the Therapeutic Management of Transplant Rejection
  115. Role of SLC11A1 (formerly NRAMP1) in regulation of signal transduction induced by Toll-like receptor 7 ligands
  116. F.23. Polymorphisms of Toll-Like Receptor 2 and 4 Genes in Asthma and COPD
  117. Skeletal muscle inflammation and nitric oxide in patients with COPD
  118. Inflammation and nitric oxide production in skeletal muscle of type 2 diabetic patients
  119. Interaction of immune complexes isolated from hepatitis C virus-infected individuals with human cell lines
  120. Lipoprotein lipase protects bovine endothelial cells from human NK cytotoxic activity
  121. Expression of CD40/CD40L is important is chicken embryo aorta transdifferentiation
  122. Leptin and leptin receptors during malaria infection in mice
  123. Activity profile in multiple sclerosis: an integrative approach A preliminary report
  124. Expression of surface molecules on eosinophils from patients with persistent allergic rhinitis (PAR), before and after treatment
  125. Clearance of Infection with Mycobacterium bovis BCG in Mice Is Enhanced by Treatment with S28463 (R-848), and Its Efficiency Depends on Expression of Wild-Type Nramp1 (Resistance Allele)
  126. Antihypertensive Treatment Decreased Serum Leptin Levels in Severe Preeclampsia during Pregnancy
  127. Endothelial Cells Scraped from the Luminal Surface of Bovine Pulmonary Artery Give Rise to Nonmuscle Cells
  128. Increased Peroxide Production by Polymorphonuclear Cells of Chronic Hepatitis C Virus-Infected Patients
  129. Expression of low‐density lipoprotein receptors in peripheral blood and tonsil B lymphocytes
  130. Characterization of Local Memory Cells in Stage‐Classified Pulmonary Tuberculosis: Preliminary Observations
  131. Phenotypic difference between Bcgr and Bcgs macrophages is related to differences in protein-kinase-C-dependent signalling
  132. Nitric Oxide in Different Types of Hypertension during Pregnancy
  133. Impaired NK cytotoxicity of NK cells of HCV patients
  134. Secretion of cytokines by natural killer cells primed with interleukin‐2 and stimulated with different lipoproteins
  135. Low density lipoprotein receptor expression and function in human polymorphonuclear leucocytes
  136. Expression and Function of Low-Density Lipoprotein Receptors in CD3−CD16+CD56+Cells: Effect of Interleukin 2
  137. Effects of Different Lipoproteins on the Proliferative Response of Interleukin-2-Activated T Lymphocytes and Large Granular Lymphocytes
  138. Dietary n-3 polyunsaturated fatty acids prevent the development of atherosclerotic lesions in mice. Modulation of macrophage secretory activities
  139. High macrophage lipoprotein lipase expression and secretion are associated in inbred murine strains with susceptibility to atherosclerosis
  140. Kinetics of product inhibition and mechanisms of lipoprotein lipase activation by apolipoprotein C-II
  141. The kinetics of heparin inhibition of the esterase and basal lipase activities of lipoprotein lipase
  142. The effects of bovine serum albumin and oleic acid on rat pancreatic lipase and bovine milk lipoprotein lipase