All Stories

  1. Correction of lung inflammation in a F508del CFTR murine cystic fibrosis model by the sphingosine-1-phosphate lyase inhibitor LX2931

    Article • AJP Lung Cellular and Molecular Physiology, September 2016, American Physiological Society

    Dr Tamas Oravecz, Dr Juan B De Sanctis

  2. Sphingosine-1-phosphate phosphatase 2 promotes disruption of mucosal integrity, and contributes to ulcerative colitis in mice and humans

    Article • The FASEB Journal, April 2016, Federation of American Societies For Experimental Biology (FASEB)

    Dr Tamas Oravecz

  3. Spinster 2, a sphingosine-1-phosphate transporter, plays a critical role in inflammatory and autoimmune diseases

    Article • The FASEB Journal, August 2015, Federation of American Societies For Experimental Biology (FASEB)

    Dr Tamas Oravecz

  4. Abstract B28: Autotaxin, LPA1 and LPA5 receptors in the tumor microenvironment determine melanoma invasion and metastasis

    Article • Cancer Research, January 2015, American Association for Cancer Research (AACR)

    Dr Tamas Oravecz

  5. Lysophosphatidic Acid Receptor 5 Inhibits B Cell Antigen Receptor Signaling and Antibody Response

    Article • The Journal of Immunology, June 2014, The American Association of Immunologists

    Dr Tamas Oravecz

  6. Genetic Deletion of Mst1 Alters T Cell Function and Protects against Autoimmunity

    Article • PLoS ONE, May 2014, PLOS

    Dr Tamas Oravecz

  7. Activation of liver X receptors inhibits experimental fibrosis by interfering with interleukin-6 release from macrophages

    Article • Annals of the Rheumatic Diseases, March 2014, BMJ

    Dr Tamas Oravecz

  8. Integrin-  FG-GAP Repeat-Containing Protein 2 Is Critical for Normal B Cell Differentiation and Controls Disease Development in a Lupus Model

    Article • The Journal of Immunology, August 2013, The American Association of Immunologists

    Dr Tamas Oravecz

  9. Lysophosphatidic Acid Inhibits CD8 T-cell Activation and Control of Tumor Progression

    Article • Cancer Immunology Research, August 2013, American Association for Cancer Research (AACR)

    Dr Tamas Oravecz

  10. Pharmacological reduction of mucosal but not neuronal serotonin opposes inflammation in mouse intestine

    Article • Gut, June 2013, BMJ

    Dr Tamas Oravecz

  11. Abstract 3884: Targeting ATX and LPA receptors melanoma invasion and metastasis.

    Article • Cancer Research, April 2013, American Association for Cancer Research (AACR)

    Dr Tamas Oravecz

  12. Tipping the Balance of Sphingosine 1-Phosphate Production: Sphingosine Kinases and Sphingosine 1-Phosphate Lyase as Immune Therapeutic Targets

    Article • July 2012, Royal Society of Chemistry

    Dr Tamas Oravecz

  13. Mo2021 Lx1606 (Aka LX1032), a Peripheral Inhibitor of Serotonin Synthesis, Alleviates Development of Inflammatory Bowel Disease in a Preclinical Model

    Article • Gastroenterology, May 2012, Elsevier

    Dr Tamas Oravecz

  14. Developmental Arrest of T Cells in Rpl22-Deficient Mice Is Dependent upon Multiple p53 Effectors

    Article • The Journal of Immunology, June 2011, The American Association of Immunologists

    Dr Tamas Oravecz

  15. A mouse model of hereditary folate malabsorption: deletion of the PCFT gene leads to systemic folate deficiency

    Article • Blood, February 2011, American Society of Hematology

    Dr Tamas Oravecz, Dr Peter Vogel

  16. Inhibition of Sphingosine 1-Phosphate Lyase for the Treatment of Rheumatoid Arthritis: Discovery of ( E )-1-(4-((1 R ,2 S ,3 R )-1,2,3,4-Tetrahydroxybutyl)-1 H -imidazol-2-yl)ethanone Oxime (LX2931) and (1 R ,2 S ,3 R )-1-(2-(Isoxazol-3-yl)-1 H -imida...

    Article • Journal of Medicinal Chemistry, December 2010, American Chemical Society (ACS)

    Dr Tamas Oravecz

  17. Regulators of the Proteasome Pathway, Uch37 and Rpn13, Play Distinct Roles in Mouse Development

    Article • PLoS ONE, October 2010, PLOS

    Dr Tamas Oravecz, Dr Peter Vogel

  18. Requirement for Class II Phosphoinositide 3-Kinase C2  in Maintenance of Glomerular Structure and Function

    Article • Molecular and Cellular Biology, October 2010, ASM Journals

    Dr Tamas Oravecz

  19. A mouse knockout library for secreted and transmembrane proteins

    Article • Nature Biotechnology, June 2010, Nature

    Dr Tamas Oravecz

  20. The Adaptor Protein Sh2d3c Is Critical for Marginal Zone B Cell Development and Function

    Article • The Journal of Immunology, May 2010, The American Association of Immunologists

    Dr Tamas Oravecz

  21. Pharmacokinetic/pharmacodynamic modelling of 2-acetyl-4(5)-tetrahydroxybutyl imidazole-induced peripheral lymphocyte sequestration through increasing lymphoid sphingosine 1-phosphate

    Article • Xenobiotica, February 2010, Taylor & Francis

    Dr Tamas Oravecz

  22. Lead optimization and structure-based design of potent and bioavailable deoxycytidine kinase inhibitors

    Article • Bioorganic & Medicinal Chemistry Letters, December 2009, Elsevier

    Dr Tamas Oravecz

  23. 5-Fluorocytosine derivatives as inhibitors of deoxycytidine kinase

    Article • Bioorganic & Medicinal Chemistry Letters, December 2009, Elsevier

    Dr Tamas Oravecz

  24. Inhibition of Sphingosine-1-Phosphate Lyase for the Treatment of Autoimmune Disorders

    Article • Journal of Medicinal Chemistry, July 2009, American Chemical Society (ACS)

    Dr Tamas Oravecz

  25. Incomplete Inhibition of Sphingosine 1-Phosphate Lyase Modulates Immune System Function yet Prevents Early Lethality and Non-Lymphoid Lesions

    Article • PLoS ONE, January 2009, PLOS

    Dr Peter Vogel, Dr Tamas Oravecz

  26. Ablation of Ribosomal Protein L22 Selectively Impairs αβ T Cell Development by Activation of a p53-Dependent Checkpoint

    Article • Immunity, June 2007, Elsevier

    Dr Tamas Oravecz

  27. Regulation of innate immunity by MAPK dual-specificity phosphatases: knockout models reveal new tricks of old genes

    Article • Journal of Leukocyte Biology, January 2007, Society for Leukocyte Biology

    Dr Tamas Oravecz

  28. Essential Role of MAPK Phosphatase-1 in the Negative Control of Innate Immune Responses

    Article • The Journal of Immunology, January 2006, The American Association of Immunologists

    Dr Tamas Oravecz

  29. Chemokine receptor CXCR4-β1 integrin axis mediates tumorigenesis of osteosarcoma HOS cells

    Article • Biochemistry and Cell Biology, February 2005, Canadian Science Publishing

    Dr Tamas Oravecz, Dr Subrata Chakrabarti

  30. Protein Kinase Cϵ Mediates PMA-Induced Growth Inhibition of Low Population Density NIH 3T3 Fibroblasts

    Article • Archives of Biochemistry and Biophysics, January 2002, Elsevier

    Dr Tamas Oravecz

  31. β1 integrin-extracellular matrix protein interaction modulates the migratory response to chemokine stimulation

    Article • Biochemistry and Cell Biology, August 2001, Canadian Science Publishing

    Dr Tamas Oravecz

  32. DIPEPTIDYL PEPTIDASE-IV AGGRAVATES HYPOTENSION DURING RAT ENDOTOXIC AND HEMORRHAGIC SHOCK.

    Article • Shock, June 2001, Wolters Kluwer Health

    Dr Tamas Oravecz

  33. β1 integrin-extracellular matrix protein interaction modulates the migratory response to chemokine stimulation

    Article • Biochemistry and Cell Biology, January 2001, Canadian Science Publishing

    Dr Tamas Oravecz

  34. CHEMICAL SYNTHESIS AND CHARACTERIZATION OF CHEMOKINE RANTES AND ITS ANALOGUES

    Article • Cytokine, January 1999, Elsevier

    Dr Tamas Oravecz

  35. A Semiautomated Fluorescence-Based Cell-to-Cell Fusion Assay for gp120–gp41 and CD4 Expressing Cells

    Article • Experimental Cell Research, April 1998, Elsevier

    Dr Tamas Oravecz

  36. Regulation of the Receptor Specificity and Function of the Chemokine RANTES (Regulated on Activation, Normal T Cell Expressed and Secreted) by Dipeptidyl Peptidase IV (CD26)-mediated Cleavage

    Article • The Journal of Experimental Medicine, December 1997, Rockefeller University Press

    Dr Tamas Oravecz

  37. CD26 expression correlates with entry, replication and cytopathicity of monocytotropic HIV–1 strains in a T–cell line

    Article • Nature Medicine, September 1995, Nature

    Dr Tamas Oravecz

  38. Effect of phytohaemagglutinin on CD45 in T cells

    Article • Immunology Letters, October 1994, Elsevier

    Dr Tamas Oravecz

  39. Novel heterogeneity of the leucocyte common antigen (CD45): disulfide-bound heterodimers between CD45 and an 80 kDa polypeptide

    Article • Immunology Letters, April 1994, Elsevier

    Dr Adrian Onu, Dr Tamas Oravecz

  40. Immunohistochemical detection of raf protein kinase in cerebral cortical areas of adult guinea pigs and rats

    Article • Brain Research, November 1993, Elsevier

    Dr Tamas Oravecz

  41. Costimulatory Properties of the Human CD4 Molecule: Enhancement of CD3-Induced T Cell Activation by Human Immunodeficiency Virus Type 1 through Viral Envelope Glycoprotein gp120

    Article • AIDS Research and Human Retroviruses, October 1993, Mary Ann Liebert Inc

    Dr Tamas Oravecz

  42. Cell-Surface Heparan Sulfate Proteoglycan Mediates HIV-1 Infection of T-Cell Lines

    Article • AIDS Research and Human Retroviruses, February 1993, Mary Ann Liebert Inc

    Dr Tamas Oravecz

  43. CD3-Induced T-Cell Proliferation and Interleukin-2 Secretion is Modulated by the CD45 Antigen

    Article • Scandinavian Journal of Immunology, November 1991, Wiley

    Dr Tamas Oravecz

  44. Immunohistochemical localization of raf protein kinase in dendritic spines and spine apparatuses of the rat cerebral cortex

    Article • Brain Research, May 1991, Elsevier

    Dr Tamas Oravecz

  45. Saturation Screening of the Druggable Mammalian Genome

    Article • Wiley

    Dr Tamas Oravecz

  46. Saturation Screening of the Druggable Mammalian Genome

    Article • Wiley

    Dr Tamas Oravecz