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  1. Obstructive and restrictive spirometry from school age to adulthood: three birth cohort studies

    Article • EClinicalMedicine, January 2024, Elsevier

    Prof. John W Holloway

  2. Identification of eczema clusters and their association with filaggrin and atopic comorbidities: analysis of five birth cohorts

    Article • British Journal of Dermatology, November 2023, Oxford University Press (OUP)

    Prof. John W Holloway

  3. European and multi-ancestry genome-wide association meta-analysis of atopic dermatitis highlights importance of systemic immune regulation

    Article • Nature Communications, October 2023, Springer Science + Business Media

    Prof. John W Holloway

  4. Analysis of DNA methylation at birth and in childhood reveals changes associated with season of birth and latitude

    Article • Clinical Epigenetics, September 2023, Springer Science + Business Media

    Prof. John W Holloway

  5. Boys who smoke in their early teens risk passing on harmful epigenetic traits to future children

    Article • Clinical Epigenetics, August 2023, Springer Science + Business Media

    Prof. John W Holloway

  6. The association of DNA methylation at birth with adolescent asthma is mediated by atopy

    Article • Clinical & Experimental Allergy, August 2023, Wiley

    Prof. John W Holloway

  7. Polymorphisms in Glutathione S-Transferase (GST) Genes Modify the Effect of Exposure to Maternal Smoking Metabolites in Pregnancy and Offspring DNA Methylation

    Article • Genes, August 2023, MDPI AG

    Prof. John W Holloway

  8. Current state and prospects of artificial intelligence in allergy

    Article • Allergy, August 2023, Wiley

    Prof. John W Holloway

  9. Genetic Associates of Childhood Wheezing Phenotypes Identified

    Article • eLife, May 2023, eLife

    Prof. John W Holloway

  10. Gene Expression in Cord Blood and Tuberculosis in Early Childhood: A Nested Case-Control Study in a South African Birth Cohort

    Article • Clinical Infectious Diseases, May 2023, Oxford University Press (OUP)

    Prof. John W Holloway

  11. Current state and prospects of artificial intelligence in allergy

    Article • April 2023, Authorea, Inc.

    Prof. John W Holloway

  12. A meta-analysis of genome-wide association studies of childhood wheezing phenotypes identifiesANXA1as a susceptibility locus for persistent wheezing

    Article • March 2023, Cold Spring Harbor Laboratory Press

    Prof. John W Holloway

  13. Preconception origins of asthma, allergies and lung function: The influence of previous generations on the respiratory health of our children

    Article • Journal of Internal Medicine, March 2023, Wiley

    Prof. John W Holloway

  14. Fathers’ preconception smoking and offspring DNA methylation: A two generation study

    Article • January 2023, Cold Spring Harbor Laboratory Press

    Prof. John W Holloway

  15. Eczema among adolescents in Kuwait: Prevalence, severity, sleep disturbance, antihistamine use, and risk factors

    Article • World Allergy Organization Journal, January 2023, Elsevier

    Prof. John W Holloway

  16. Evolution of Eczema, Wheeze, and Rhinitis from Infancy to Early Adulthood: Four Birth Cohort Studies

    Article • American Journal of Respiratory and Critical Care Medicine, October 2022, American Thoracic Society

    Professor Adnan Custovic, Prof. John W Holloway

  17. The role of epigenetics in multi‐generational transmission of asthma: An NIAID workshop report‐based narrative review

    Article • Clinical & Experimental Allergy, October 2022, Wiley

    Prof. John W Holloway

  18. Measurement of Exhaled Volatile Organic Compounds as a Biomarker for Personalised Medicine: Assessment of Short-Term Repeatability in Severe Asthma

    Article • Journal of Personalized Medicine, October 2022, MDPI AG

    Prof. John W Holloway

  19. Pre-pubertal smoke exposure of fathers and increased risk of offspring asthma: a possible transgenerational effect

    Article • European Respiratory Journal, September 2022, European Respiratory Society (ERS)

    Dr Gayan Bowatte, Prof. John W Holloway

  20. Paternal pre-pubertal tobacco smoking and offspring DNA methylation

    Article • September 2022, European Respiratory Society (ERS)

    Prof. John W Holloway

  21. Omics and Lung Function: A Need for Integration

    Article • American Journal of Respiratory and Critical Care Medicine, August 2022, American Thoracic Society

    Prof. John W Holloway

  22. British Society for Allergy and Immunology ( BSACI ) Abstracts of the World Allergy Organization ( WAO ) & BSACI 2022 UK...

    Article • Clinical & Experimental Allergy, July 2022, Wiley

    Prof. John W Holloway

  23. Association of childhood BMI trajectory with post-adolescent and adult lung function is mediated by pre-adolescent DNA methylation

    Article • July 2022, Springer Science + Business Media

    Prof. John W Holloway

  24. Association of upper airway bacterial microbiota and asthma: systematic review

    Article • Asia Pacific Allergy, July 2022, Wolters Kluwer Health

    Woo-Jung Song, Prof. John W Holloway

  25. Parental preconception BMI trajectories from childhood to adolescence and asthma in the future offspring

    Article • Journal of Allergy and Clinical Immunology, July 2022, Elsevier

    Prof. John W Holloway

  26. Temporal Whole-Transcriptomic Analysis of Characterized In Vitro and Ex Vivo Primary Nasal Epithelia

    Article • Frontiers in Cell and Developmental Biology, June 2022, Frontiers

    Prof. John W Holloway

  27. Ascaris exposure and its association with lung function, asthma, and DNA methylation in Northern Europe

    Article • Journal of Allergy and Clinical Immunology, June 2022, Elsevier

    Prof. John W Holloway

  28. Modeling Wheezing Spells Identifies Phenotypes with Different Outcomes and Genetic Associates

    Article • American Journal of Respiratory and Critical Care Medicine, April 2022, American Thoracic Society

    Professor Adnan Custovic, Prof. John W Holloway

  29. Nonlinear effects of environment on childhood asthma susceptibility

    Article • Pediatric Allergy and Immunology, April 2022, Wiley

    Professor Adnan Custovic, Prof. John W Holloway

  30. Article • Pediatric Allergy and Immunology, April 2022, Wiley

    Prof. John W Holloway

  31. Placental uptake and metabolism of 25(OH)vitamin D determine its activity within the fetoplacental unit

    Article • eLife, March 2022, eLife

    Prof. John W Holloway

  32. Article • Pediatric Allergy and Immunology, March 2022, Wiley

    Prof. John W Holloway

  33. Associations between child filaggrin mutations and maternal diet with the development of allergic diseases in children

    Article • Pediatric Allergy and Immunology, March 2022, Wiley

    Prof. John W Holloway

  34. Predicting Pulmonary Function From the Analysis of Voice: A Machine Learning Approach

    Article • Frontiers in Digital Health, February 2022, Frontiers

    Prof. John W Holloway

  35. Does DNA methylation mediate the association of age at puberty with FVC or FEV1?

    Article • ERJ Open Research, February 2022, European Respiratory Society (ERS)

    Prof. John W Holloway

  36. DNA Methylation and Asthma Acquisition during Adolescence and Post-Adolescence, an Epigenome-Wide Longitudinal Study

    Article • Journal of Personalized Medicine, February 2022, MDPI AG

    Prof. John W Holloway

  37. Newborn DNA methylation and asthma acquisition across adolescence and early adulthood

    Article • Clinical & Experimental Allergy, January 2022, Wiley

    Prof. John W Holloway

  38. Integration of Genomic Risk Scores to Improve the Prediction of Childhood Asthma Diagnosis

    Article • Journal of Personalized Medicine, January 2022, MDPI AG

    Professor Adnan Custovic, Prof. John W Holloway

  39. Meta-analysis of epigenome-wide association studies in newborns and children show widespread sex differences in blood DNA methylation

    Article • Mutation Research/Reviews in Mutation Research, January 2022, Elsevier

    Prof. John W Holloway

  40. Association of prenatal acetaminophen use and acetaminophen metabolites with DNA methylation of newborns: analysis of two consecutive generations of the Isle of Wight birth cohort

    Article • Environmental Epigenetics, January 2022, Oxford University Press (OUP)

    Prof. John W Holloway

  41. Residential greenness-related DNA methylation changes

    Article • Environment International, January 2022, Elsevier

    Prof. John W Holloway

  42. Development of childhood asthma prediction models using machine learning approaches

    Article • Clinical and Translational Allergy, November 2021, Wiley

    Professor Adnan Custovic, Prof. John W Holloway

  43. Spirometric phenotypes from early childhood to young adulthood: a Chronic Airway Disease Early Stratification study

    Article • ERJ Open Research, September 2021, European Respiratory Society (ERS)

    Erik Melén, Professor Adnan Custovic, Prof. John W Holloway

  44. Transcriptome analysis of ciliary differentiation in airway epithelium

    Article • September 2021, European Respiratory Society (ERS)

    Prof. John W Holloway

  45. Exposures during the prepuberty period and future offspring’s health: evidence from human cohort studies†

    Article • Biology of Reproduction, August 2021, Oxford University Press (OUP)

    Prof. John W Holloway

  46. BMI trajectory in childhood is associated with asthma incidence at young adulthood mediated by DNA methylation

    Article • Allergy Asthma & Clinical Immunology, July 2021, Springer Science + Business Media

    Prof. John W Holloway

  47. Childhood food allergy and food allergen sensitisation are associated with adult airways disease: A birth cohort study

    Article • Pediatric Allergy and Immunology, July 2021, Wiley

    Prof. John W Holloway

  48. Rapid microfluidic isolation of virally infected primary bronchial epithelial cells for single-cell RNA sequencing

    Article • BioTechniques, July 2021, Future Science

    Prof. John W Holloway

  49. Preconceptional smoking alters spermatozoal miRNAs of murine fathers and affects offspring’s body weight

    Article • International Journal of Obesity, May 2021, Springer Science + Business Media

    Prof. John W Holloway

  50. Distinct immune responses in patients infected with influenza or SARS-CoV-2, and in COVID-19 survivors, characterised by transcriptomic and cellular abundance differences in blood

    Article • May 2021, Cold Spring Harbor Laboratory Press

    Prof. John W Holloway

  51. Causal Effects of Body Mass Index on Airflow Obstruction and Forced Mid-Expiratory Flow: A Mendelian Randomization Study Taking Interactions and Age-Specific Instruments Into Consideration Toward a Life Course Perspective

    Article • Frontiers in Public Health, May 2021, Frontiers

    Prof. John W Holloway

  52. Gaussian Bayesian network comparisons with graph ordering unknown

    Article • Computational Statistics & Data Analysis, May 2021, Elsevier

    Prof. John W Holloway

  53. Sex-specific longitudinal association of DNA methylation with lung function

    Article • ERJ Open Research, April 2021, European Respiratory Society (ERS)

    Prof. John W Holloway

  54. Development of Childhood Asthma Prediction Models using Machine Learning Approaches

    Article • April 2021, Cold Spring Harbor Laboratory Press

    Prof. John W Holloway, Professor Adnan Custovic

  55. Prenatal and prepubertal exposures to tobacco smoke in men may cause lower lung function in future offspring: a three-generation study using a causal modelling approach

    Article • European Respiratory Journal, April 2021, European Respiratory Society (ERS)

    Prof. John W Holloway

  56. Epigenome-scale comparison of DNA methylation between blood leukocytes and bronchial epithelial cells

    Article • Epigenomics, April 2021, Future Medicine

    Prof. John W Holloway

  57. Pre-adolescence DNA methylation is associated with BMI status change from pre- to post-adolescence

    Article • Clinical Epigenetics, March 2021, Springer Science + Business Media

    Prof. John W Holloway

  58. Next Generation Exome Sequencing of Pediatric Asthma Identifies Rare and Novel Variants in Candidate Genes

    Article • Disease Markers, February 2021, Hindawi Publishing Corporation

    Prof. John W Holloway

  59. Pre-adolescence DNA methylation is associated with lung function trajectories from pre-adolescence to adulthood

    Article • Clinical Epigenetics, January 2021, Springer Science + Business Media

    Prof. John W Holloway

  60. DNA Methylation at Birth is Associated with Childhood Serum Immunoglobulin E Levels

    Article • Epigenetics Insights, January 2021, SAGE Publications

    Prof. John W Holloway

  61. Phenotypic and functional translation of IL33 genetics in asthma

    Article • Journal of Allergy and Clinical Immunology, January 2021, Elsevier

    Prof. John W Holloway

  62. Epigenome-Wide Association of Infant Feeding and Changes in DNA Methylation from Birth to 10 Years

    Article • Nutrients, December 2020, MDPI AG

    Prof. John W Holloway

  63. Nicotine and Its Downstream Metabolites in Maternal and Cord Sera: Biomarkers of Prenatal Smoking Exposure Associated with Offspring DNA Methylation

    Article • International Journal of Environmental Research and Public Health, December 2020, MDPI AG

    Prof. John W Holloway

  64. Maternal high fat diet in mice alters immune regulation and lung function in the offspring

    Article • British Journal Of Nutrition, November 2020, Cambridge University Press

    Prof. John W Holloway

  65. DNA methylation and body mass index from birth to adolescence: meta-analyses of epigenome-wide association studies

    Article • Genome Medicine, November 2020, Springer Science + Business Media

    Prof. John W Holloway

  66. Sex‐specific associations of asthma acquisition with changes in DNA methylation during adolescence

    Article • Clinical & Experimental Allergy, November 2020, Wiley

    Prof. John W Holloway

  67. DNA methylation at birth is associated with lung function development until age 26 years

    Article • European Respiratory Journal, November 2020, European Respiratory Society (ERS)

    Wilfried Karmaus, Prof. John W Holloway

  68. Prediction of Lung Function in Adolescence Using Epigenetic Aging: A Machine Learning Approach

    Article • Methods and Protocols, November 2020, MDPI AG

    Prof. John W Holloway

  69. Reply to Owora et al.

    Article • Pediatric Allergy and Immunology, November 2020, Wiley

    Prof. John W Holloway

  70. Heritable hazards of smoking: Applying the “clean sheet” framework to further science and policy

    Article • Environmental and Molecular Mutagenesis, October 2020, Wiley

    Prof. John W Holloway

  71. Pubertal onset with adulthood lung function mediated by height growth in adolescence

    Article • ERJ Open Research, September 2020, European Respiratory Society (ERS)

    Prof. John W Holloway

  72. Prediction of Lung Function in Adolescence Using Epigenetic Aging: A Machine Learning Approach

    Article • September 2020, MDPI AG

    Prof. John W Holloway

  73. Association of Maternal DNA Methylation and Offspring Birthweight

    Article • Reproductive Sciences, August 2020, Springer Science + Business Media

    Prof. John W Holloway

  74. Cohort Profile Update: The Isle of Wight Whole Population Birth Cohort (IOWBC)

    Article • International Journal of Epidemiology, July 2020, Oxford University Press (OUP)

    Prof. John W Holloway

  75. Assessing small airway function for early detection of lung function impairment

    Article • European Respiratory Journal, July 2020, European Respiratory Society (ERS)

    Prof. John W Holloway

  76. Role of DNA methylation in the association of lung function with body mass index: a two-step epigenetic Mendelian randomisation study

    Article • BMC Pulmonary Medicine, June 2020, Springer Science + Business Media

    Prof. John W Holloway

  77. Genome-Wide DNA Methylation in Peripheral Blood and Long-Term Exposure to Source-Specific Transportation Noise and Air Pollution: The SAPALDIA Study

    Article • Environmental Health Perspectives, June 2020, Environmental Health Perspectives

    Prof. John W Holloway

  78. Breastfeeding changes infants DNA

    Article • International Journal of Environmental Research and Public Health, May 2020, MDPI AG

    Prof. John W Holloway

  79. Phenotypic and functional translation of IL1RL1 locus polymorphisms in lung tissue and asthmatic airway epithelium

    Article • JCI Insight, April 2020, American Society for Clinical Investigation

    Prof. John W Holloway

  80. Changes of DNA methylation are associated with changes in lung function during adolescence

    Article • April 2020, Springer Science + Business Media

    Prof. John W Holloway

  81. Prediction Models for Childhood Asthma: A Systematic Review

    Article • Pediatric Allergy and Immunology, March 2020, Wiley

    Prof. John W Holloway

  82. Epigenome-wide meta-analysis of blood DNA methylation in newborns and children identifies numerous loci related to gestational age

    Article • Genome Medicine, March 2020, Springer Science + Business Media

    Prof. John W Holloway

  83. Association of adult lung function with accelerated biological aging

    Article • Aging, January 2020, Impact Journals, LLC

    Prof. John W Holloway, Andre FS Amaral

  84. Cold-induced urticarial autoinflammatory syndrome related to factor XII activation

    Article • Nature Communications, January 2020, Springer Science + Business Media

    Prof. John W Holloway

  85. Different Measures of Diet Diversity During Infancy and the Association with Childhood Food Allergy in a UK Birth Cohort Study

    Article • The Journal of Allergy and Clinical Immunology In Practice, January 2020, Elsevier

    Prof. John W Holloway

  86. Age at onset of different pubertal signs in boys and girls and differential DNA methylation at age 10 and 18 years: an epigenome-wide follow-up study

    Article • Human Reproduction Open, January 2020, Oxford University Press (OUP)

    Prof. John W Holloway

  87. Interweaving Between Genetic and Epigenetic Studies on Childhood Asthma

    Article • Epigenetics Insights, January 2020, SAGE Publications

    Prof. John W Holloway

  88. Paternal DNA Methylation May Be Associated With Gestational Age at Birth

    Article • Epigenetics Insights, January 2020, SAGE Publications

    Prof. John W Holloway

  89. An evaluation of different classification algorithms for protein sequence-based reverse vaccinology prediction

    Article • PLoS ONE, December 2019, PLOS

    Prof. John W Holloway

  90. Association of asthma and smoking with lung function impairment in adolescence and early adulthood: the Isle of Wight Birth Cohort Study

    Article • European Respiratory Journal, December 2019, European Respiratory Society (ERS)

    Prof. John W Holloway

  91. Epigenome wide comparison of DNA methylation profile between paired umbilical cord blood and neonatal blood on Guthrie cards

    Article • Epigenetics, December 2019, Taylor & Francis

    Prof. John W Holloway

  92. Changes in DNA methylation from pre- to post-adolescence are associated with pubertal exposures

    Article • Clinical Epigenetics, December 2019, Springer Science + Business Media

    Prof. John W Holloway

  93. Estimation of Eosinophil Cells in Cord Blood with References Based on Blood in Adults via Bayesian Measurement Error Modeling

    Article • Bioinformatics, November 2019, Oxford University Press (OUP)

    Prof. John W Holloway

  94. Epigenome-wide association of father’s smoking with offspring DNA methylation: a hypothesis-generating study

    Article • Environmental Epigenetics, October 2019, Oxford University Press (OUP)

    Prof. John W Holloway

  95. GWAS on longitudinal growth traits reveals different genetic factors influencing infant, child, and adult BMI

    Article • Science Advances, September 2019, American Association for the Advancement of Science

    Dr Ulla Sovio, Prof. John W Holloway, Professor Alina Rodriguez

  96. Duration of breastfeeding is associated with leptin (LEP) DNA methylation profiles and BMI in 10-year-old children

    Article • Clinical Epigenetics, August 2019, Springer Science + Business Media

    Prof. John W Holloway

  97. Epigenome-wide association study of asthma and wheeze characterizes loci within HK1

    Article • Allergy Asthma & Clinical Immunology, July 2019, Springer Science + Business Media

    Prof. John W Holloway

  98. Distinguishing Wheezing Phenotypes from Infancy to Adolescence. A Pooled Analysis of Five Birth Cohorts

    Article • Annals of the American Thoracic Society, July 2019, American Thoracic Society

    Prof. John W Holloway, Professor Adnan Custovic

  99. DNA methylation links prenatal smoking exposure to later life health outcomes in offspring

    Article • Clinical Epigenetics, July 2019, Springer Science + Business Media

    Prof. John W Holloway, Professor Alina Rodriguez

  100. Hypertensive Disorders of Pregnancy and DNA Methylation in Newborns

    Article • Hypertension, June 2019, Wolters Kluwer Health

    Prof. John W Holloway, Jari Lahti

  101. Effect of gestational oily fish intake on the risk of allergy in children may be influenced by FADS1/2, ELOVL5 expression and DNA methylation

    Article • Genes & Nutrition, June 2019, Springer Science + Business Media

    Prof. John W Holloway

  102. Thioflavin T Monitoring of Guanine Quadruplex Formation in the rs689-Dependent INS Intron 1

    Article • Molecular Therapy — Nucleic Acids, June 2019, Elsevier

    Prof. John W Holloway

  103. Reply

    Article • Journal of Allergy and Clinical Immunology, June 2019, Elsevier

    Prof. John W Holloway

  104. Epigenome-wide association study of lung function level and its change

    Article • European Respiratory Journal, May 2019, European Respiratory Society (ERS)

    Prof. John W Holloway, Andre FS Amaral, Dr. Diana A van der Plaat

  105. Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors

    Article • Nature Genetics, May 2019, Springer Science + Business Media

    Prof. John W Holloway, Jonas Bacelis, Gunn-Helen Moen

  106. Meta-analysis of epigenome-wide association studies in neonates reveals widespread differential DNA methylation associated with birthweight

    Article • Nature Communications, April 2019, Springer Science + Business Media

    Prof. John W Holloway, Dr. Diana A van der Plaat, Jari Lahti

  107. The Early Growth Genetics (EGG) and EArly Genetics and Lifecourse Epidemiology (EAGLE) consortia: design, results and future prospects

    Article • European Journal of Epidemiology, March 2019, Springer Science + Business Media

    Prof. John W Holloway, Jari Lahti, Professor Adnan Custovic

  108. Different definitions of atopic dermatitis: Impact on prevalence estimates and associated risk factors

    Article • British Journal of Dermatology, March 2019, Wiley

    Prof. John W Holloway, Professor Adnan Custovic

  109. DNA methylation and allergic sensitizations, a genome-scale longitudinal study during adolescence

    Article • Allergy, February 2019, Wiley

    Prof. John W Holloway

  110. The Hertfordshire Cohort Study: an overview

    Article • F1000Research, January 2019, Faculty of 1000, Ltd.

    Sian Robinson, Prof. John W Holloway

  111. Moderate-to-severe asthma in individuals of European ancestry: a genome-wide association study

    Article • The Lancet Respiratory Medicine, January 2019, Elsevier

    Prof. John W Holloway

  112. Pubertal height growth and lung function in adolescence and early adulthood

    Article • American Journal of Respiratory and Critical Care Medicine, December 2018, American Thoracic Society

    Prof. John W Holloway, Osama Mahmoud, Professor Adnan Custovic

  113. Environmental Impact on Health across Generations: Policy Meets Biology. A Review of Animal and Human Models

    Article • Challenges, December 2018, MDPI AG

    Prof. John W Holloway

  114. Causes of variability in latent phenotypes of childhood wheeze

    Article • Journal of Allergy and Clinical Immunology, December 2018, Elsevier

    Prof. John W Holloway, Prof. Ultan F Power, Professor Adnan Custovic

  115. Epigenome-wide Meta-analysis of DNA Methylation and Childhood Asthma

    Article • Journal of Allergy and Clinical Immunology, December 2018, Elsevier

    Prof. John W Holloway, Jari Lahti

  116. Breastfeeding duration modifies the effect of smoking during pregnancy on eczema from early childhood to adolescence

    Article • Clinical & Experimental Allergy, October 2018, Wiley

    Prof. John W Holloway

  117. Role of DNA Methylation in Type 2 Diabetes Etiology: Using Genotype as a Causal Anchor

    Article • Yearbook of Paediatric Endocrinology, September 2018, Bioscientifica

    Prof. John W Holloway

  118. Changes in miRNA Gene Expression during Wound Repair in Differentiated Normal Human Bronchial Epithelium

    Article • International Journal of Genomics, September 2018, Hindawi Publishing Corporation

    Prof. John W Holloway, Monika Dmitrzak-Węglarz, Claire Jackson

  119. SERPINA1 methylation and lung function in tobacco-smoke exposed European children and adults: a meta-analysis of ALEC population-based cohorts

    Article • Respiratory Research, August 2018, Springer Science + Business Media

    Prof. John W Holloway, Andre FS Amaral

  120. Maternal dietary antioxidant intake in pregnancy and childhood respiratory and atopic outcomes: birth cohort study

    Article • European Respiratory Journal, August 2018, European Respiratory Society (ERS)

    Prof. John W Holloway

  121. The Canmore Declaration: Statement of Principles for Planetary Health

    Article • Challenges, July 2018, MDPI AG

    Prof. John W Holloway

  122. Trans- and inter-generational epigenetic inheritance in allergic diseases

    Article • Journal of Allergy and Clinical Immunology, July 2018, Elsevier

    Prof. John W Holloway

  123. Cohort Profile: The Isle Of Wight Whole Population Birth Cohort (IOWBC)

    Article • International Journal of Epidemiology, March 2018, Oxford University Press (OUP)

    Prof. John W Holloway

  124. A three-generation study on the association of tobacco smoking with asthma

    Article • International Journal of Epidemiology, March 2018, Oxford University Press (OUP)

    Prof. John W Holloway

  125. Acquisition, remission, and persistence of eczema, asthma, and rhinitis in children

    Article • Clinical & Experimental Allergy, February 2018, Wiley

    Prof. John W Holloway, Wilfried Karmaus

  126. Changes in DNA Methylation from Age 18 to Pregnancy in Type 1, 2, and 17 T Helper and Regulatory T-Cells Pathway Genes

    Article • International Journal of Molecular Sciences, February 2018, MDPI AG

    Prof. John W Holloway

  127. Fixed Airways Obstruction In Smokers At 26 Years Of Age; An Early Indication Of COPD?

    Article • Journal of Allergy and Clinical Immunology, February 2018, Elsevier

    Prof. John W Holloway

  128. Lung Function Trajectories From Childhood To Young Adulthood; A Peek Into The Future Of Lung Health?

    Article • Journal of Allergy and Clinical Immunology, February 2018, Elsevier

    Prof. John W Holloway

  129. Asthma Does Not Explain A Decline In Post Bronchodilator Lung Function In Early Adult Life

    Article • Journal of Allergy and Clinical Immunology, February 2018, Elsevier

    Prof. John W Holloway

  130. Filaggrin mutations increase allergic airway disease in childhood and adolescence through interactions with eczema and aeroallergen sensitization

    Article • Clinical & Experimental Allergy, January 2018, Wiley

    Prof. John W Holloway, Wilfried Karmaus

  131. Genome-wide association study of offspring birth weight in 86 577 women identifies five novel loci and highlights maternal genetic effects that are independent of fetal genetics

    Article • Human Molecular Genetics, January 2018, Oxford University Press (OUP)

    Prof. John W Holloway

  132. Subclonal Evolution of Cancer-Related Gene Mutations in p53 Immunopositive Patches in Human Skin

    Article • Journal of Investigative Dermatology, January 2018, Elsevier

    Prof. John W Holloway

  133. Zoonotic helminth exposure and risk of allergic diseases: A study of two generations in Norway

    Article • Clinical & Experimental Allergy, December 2017, Wiley

    Prof. John W Holloway

  134. Maternal and fetal genetic contribution to gestational weight gain

    Article • International Journal of Obesity, October 2017, Nature

    Prof. John W Holloway

  135. Cohort Profile: Pregnancy And Childhood Epigenetics (PACE) Consortium

    Article • International Journal of Epidemiology, September 2017, Oxford University Press (OUP)

    Prof. John W Holloway, Jari Lahti

  136. Rhinitis Characterisation at 26 Years in the Isle of Wight Cohort

    Article • September 2017, European Respiratory Society (ERS)

    Prof. John W Holloway

  137. Atopic Sensitisation of the Isle of Wight Birth Cohort at 26 Years

    Article • September 2017, European Respiratory Society (ERS)

    Prof. John W Holloway

  138. Wheezing Characterisation of the Isle of Wight Birth Cohort at 26 Years

    Article • September 2017, European Respiratory Society (ERS)

    Prof. John W Holloway

  139. DNA methylation profiles between airway epithelium and proxy tissues in children

    Article • Acta Paediatrica, August 2017, Wiley

    Prof. John W Holloway

  140. MicroRNA-328 is involved in wound repair process in human bronchial epithelial cells

    Article • Respiratory Physiology & Neurobiology, August 2017, Elsevier

    Prof. John W Holloway

  141. Maternal BMI at the start of pregnancy and offspring epigenome-wide DNA methylation: findings from the pregnancy and childhood epigenetics (PACE) consortium

    Article • Human Molecular Genetics, July 2017, Oxford University Press (OUP)

    Prof. John W Holloway

  142. Expression of the filaggrin gene in umbilical cord blood predicts eczema risk in infancy: A birth cohort study

    Article • Clinical & Experimental Allergy, June 2017, Wiley

    Prof. John W Holloway, Wilfried Karmaus

  143. Response to antenatal cholecalciferol supplementation is associated with common vitamin D related genetic variants

    Article • The Journal of Clinical Endocrinology & Metabolism, May 2017, Endocrine Society

    Prof. John W Holloway, Sian Robinson, Keith Godfrey

  144. Systematic review of lung function and COPD with peripheral blood DNA methylation in population based studies

    Article • BMC Pulmonary Medicine, March 2017, Springer Science + Business Media

    Andre FS Amaral, Prof. John W Holloway

  145. Role of DNA Methylation in Type 2 Diabetes Etiology: Using Genotype as a Causal Anchor

    Article • Diabetes, February 2017, American Diabetes Association

    Prof. John W Holloway

  146. Multigenerational cohorts in patients with asthma and allergy

    Article • Journal of Allergy and Clinical Immunology, February 2017, Elsevier

    Prof. John W Holloway

  147. The Origins of Allergic Disease

    Article • January 2017, Elsevier

    Prof. John W Holloway

  148. Consistency and Variability of DNA Methylation in Women During Puberty, Young Adulthood, and Pregnancy

    Article • Genetics & Epigenetics, January 2017, SAGE Publications

    Prof. John W Holloway, Wilfried Karmaus

  149. Urinary prostanoids in preschool wheeze

    Article • European Respiratory Journal, December 2016, European Respiratory Society (ERS)

    Professor David Price, Prof. John W Holloway, Professor Marek Sanak

  150. TRPA1gene polymorphisms and childhood asthma

    Article • Pediatric Allergy and Immunology, December 2016, Wiley

    Prof. John W Holloway

  151. Tetanus vaccination is associated with differential DNA-methylation: Reduces the risk of asthma in adolescence

    Article • Vaccine, December 2016, Elsevier

    Prof. John W Holloway

  152. Comparison of miRNA profiling during airway epithelial repair in undifferentiated and differentiated cells in vitro

    Article • Journal of Applied Genetics, October 2016, Springer Science + Business Media

    Prof. John W Holloway

  153. Airway and peripheral urokinase plasminogen activator receptor is elevated in asthma, and identifies a severe, nonatopic subset of patients

    Article • Allergy, October 2016, Wiley

    Prof. John W Holloway

  154. Protocadherin-1 Localization and Cell-Adhesion Function in Airway Epithelial Cells in Asthma

    Article • PLoS ONE, October 2016, PLOS

    Prof. John W Holloway

  155. Is there an association between season of birth and blood DNA methylation in adulthood?

    Article • Allergy, September 2016, Wiley

    Prof. John W Holloway

  156. Variable selection in semi-parametric models

    Article • Statistical Methods in Medical Research, July 2016, SAGE Publications

    Prof. John W Holloway

  157. Evidence for three genetic loci involved in both anorexia nervosa risk and variation of body mass index

    Article • Molecular Psychiatry, May 2016, Springer Science + Business Media

    Prof Alexander P Maxwell, Prof. John W Holloway, Professor Alina Rodriguez

  158. Adaptation to Life in the High Andes: Nocturnal Oxyhemoglobin Saturation in Early Development

    Article • SLEEP, May 2016, Oxford University Press (OUP)

    Prof. John W Holloway

  159. DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis

    Article • The American Journal of Human Genetics, April 2016, Elsevier

    Prof. John W Holloway

  160. Season of birth, epigenetics, and allergic disease

    Article • Allergy, March 2016, Wiley

    Prof. John W Holloway

  161. Exome-wide analysis of rare coding variation identifies novel associations with COPD and airflow limitation inMOCS3,IFIT3andSERPINA12

    Article • Thorax, February 2016, BMJ

    Prof. John W Holloway

  162. Relation of FTO gene variants to fetal growth trajectories: Findings from the Southampton Women's survey

    Article • Placenta, February 2016, Elsevier

    Prof. John W Holloway, Professor Rohan M Lewis

  163. Interaction between theDNAH9gene and early smoke exposure in bronchial hyperresponsiveness

    Article • European Respiratory Journal, January 2016, European Respiratory Society (ERS)

    Prof. John W Holloway

  164. Evaluating the efficacy of breastfeeding guidelines on long-term outcomes for allergic disease

    Article • Allergy, January 2016, Wiley

    Prof. John W Holloway

  165. The Genetics of Allergic Disease and Asthma

    Article • January 2016, Elsevier

    Prof. John W Holloway

  166. Identifying heterogeneous transgenerational DNA methylation sites via clustering in beta regression

    Article • The Annals of Applied Statistics, December 2015, Institute of Mathematical Statistics

    Prof. John W Holloway

  167. Breeding and Reproductive Phenology of Eastern Diamond-Backed Rattlesnakes (Crotalus adamanteus) in South Carolina

    Article • Journal of Herpetology, December 2015, Society for the Study of Amphibians and Reptiles

    Prof. John W Holloway

  168. Parent-determined oral montelukast therapy for preschool wheeze with stratification for arachidonate 5-lipoxygenase (ALOX5) promoter genotype: a multicentre, randomised, placebo-controlled trial

    Article • Efficacy and Mechanism Evaluation, November 2015, National Institute for Health Research

    Prof. John W Holloway

  169. Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis

    Article • Nature Genetics, October 2015, Nature

    Prof. John W Holloway, Jonas Bacelis, Professor Adnan Custovic

  170. DNA methylation loci associated with atopy and high serum IgE: a genome-wide application of recursive Random Forest feature selection

    Article • Genome Medicine, August 2015, Springer Science + Business Media

    Prof. John W Holloway

  171. Does allergy beginin utero?

    Article • Pediatric Allergy and Immunology, July 2015, Wiley

    Prof. John W Holloway

  172. Protocadherin-1 binds to SMAD3 and suppresses TGF-β1-induced gene transcription

    Article • AJP Lung Cellular and Molecular Physiology, July 2015, American Physiological Society

    Prof. John W Holloway

  173. Identifying CpG sites associated with eczema via random forest screening of epigenome-scale DNA methylation

    Article • Clinical Epigenetics, July 2015, Springer Science + Business Media

    Prof. John W Holloway

  174. A statistical method for single sample analysis of HumanMethylation450 array data: genome-wide methylation analysis of patients with imprinting disorders

    Article • Clinical Epigenetics, April 2015, Springer Science + Business Media

    Prof. John W Holloway

  175. Exome Analysis of Patients with Concurrent Pediatric Inflammatory Bowel Disease and Autoimmune Disease

    Article • Inflammatory Bowel Diseases, April 2015, Wolters Kluwer Health

    Prof. John W Holloway

  176. Maternal selenium status in pregnancy, offspring glutathione peroxidase 4 genotype, and childhood asthma

    Article • Journal of Allergy and Clinical Immunology, April 2015, Elsevier

    Prof. John W Holloway

  177. Rapid detection of diagnostic targets using isothermal amplification and HyBeacon probes – A homogenous system for sequence-specific detection

    Article • Molecular and Cellular Probes, April 2015, Elsevier

    Prof. John W Holloway

  178. The Study Team for Early Life Asthma Research (STELAR) consortium ‘Asthma e-lab’: team science bringing data, methods and investigators together: Figure 1

    Article • Thorax, March 2015, BMJ

    Prof. John W Holloway, Professor Adnan Custovic

  179. Effects of phthalate exposure on asthma may be mediated through alterations in DNA methylation

    Article • Clinical Epigenetics, March 2015, Springer Science + Business Media

    Prof. John W Holloway

  180. Dietary Intake, FTO Genetic Variants, and Adiposity: A Combined Analysis of Over 16,000 Children and Adolescents

    Article • Diabetes, February 2015, American Diabetes Association

    Dr Jessica C Kiefte-de Jong, Prof. John W Holloway

  181. Developmental determinants in non-communicable chronic diseases and ageing

    Article • Thorax, January 2015, BMJ

    Prof. John W Holloway

  182. A novel common variant in DCST2 is associated with length in early life and height in adulthood

    Article • Human Molecular Genetics, October 2014, Oxford University Press (OUP)

    Prof. John W Holloway, Professor Alina Rodriguez, Professor Adnan Custovic

  183. Intermittent montelukast in children aged 10 months to 5 years with wheeze (WAIT trial): a multicentre, randomised, placebo-controlled trial

    Article • The Lancet Respiratory Medicine, October 2014, Elsevier

    Prof. John W Holloway, Professor Marek Sanak

  184. Filaggrin loss-of-function mutations are associated with food allergy in childhood and adolescence

    Article • Journal of Allergy and Clinical Immunology, October 2014, Elsevier

    Prof. John W Holloway

  185. Allergic sensitization and filaggrin variants predispose to the comorbidity of eczema, asthma, and rhinitis: results from the Isle of Wight birth cohort

    Article • Clinical & Experimental Allergy, August 2014, Wiley

    Prof. John W Holloway, Wilfried Karmaus

  186. FTO genetic variants, dietary intake and body mass index: insights from 177 330 individuals

    Article • Human Molecular Genetics, August 2014, Oxford University Press (OUP)

    Prof. John W Holloway

  187. Variants Close to NTRK2 Gene Are Associated With Birth Weight in Female Twins

    Article • Twin Research and Human Genetics, June 2014, Cambridge University Press

    Prof. John W Holloway

  188. Alpha‐tryptase gene variation is associated with levels of circulating I g E and lung function in asthma

    Article • Clinical & Experimental Allergy, May 2014, Wiley

    Prof. John W Holloway

  189. Asthma genetics and personalised medicine

    Article • The Lancet Respiratory Medicine, May 2014, Elsevier

    Prof. John W Holloway

  190. Genome-wide association study of sexual maturation in males and females highlights a role for body mass and menarche loci in male puberty

    Article • Human Molecular Genetics, April 2014, Oxford University Press (OUP)

    Prof. John W Holloway, Professor Alina Rodriguez

  191. Prenatal development is linked to bronchial reactivity: epidemiological and animal model evidence

    Article • Scientific Reports, April 2014, Nature

    Prof. John W Holloway

  192. Faculty of 1000 evaluation for DNA methylation and body-mass index: a genome-wide analysis.

    Article • March 2014, Faculty of 1000, Ltd.

    Prof. John W Holloway

  193. Infant lung function and wheeze in later childhood in the Southampton Women's Survey

    Article • European Respiratory Journal, February 2014, European Respiratory Society (ERS)

    Prof. John W Holloway

  194. Genome-wide DNA methylation analysis of patients with imprinting disorders identifies differentially methylated regions associated with novel candidate imprinted genes

    Article • Journal of Medical Genetics, February 2014, BMJ

    Prof. John W Holloway

  195. Association of Filaggrin Variants with Asthma and Rhinitis: Is Eczema or Allergic Sensitization Status an Effect Modifier?

    Article • International Archives of Allergy and Immunology, January 2014, Karger Publishers

    Prof. John W Holloway

  196. Oral contraceptives modify the effect of GATA3 polymorphisms on the risk of asthma at the age of 18 years via DNA methylation

    Article • Clinical Epigenetics, January 2014, Springer Science + Business Media

    Prof. John W Holloway

  197. Prenatal alcohol exposure and childhood atopic disease: A Mendelian randomization approach

    Article • Journal of Allergy and Clinical Immunology, January 2014, Elsevier

    Prof. John W Holloway

  198. The interplay of DNA methylation over time with Th2 pathway genetic variants on asthma risk and temporal asthma transition

    Article • Clinical Epigenetics, January 2014, Springer Science + Business Media

    Prof. John W Holloway

  199. Epigenomics and allergic disease

    Article • Epigenomics, December 2013, Future Medicine

    Prof. John W Holloway

  200. A genome-wide association study identifies CDHR3 as a susceptibility locus for early childhood asthma with severe exacerbations

    Article • Nature Genetics, November 2013, Nature

    Prof. John W Holloway, Professor Adnan Custovic

  201. EAACI position statement on asthma exacerbations and severe asthma

    Article • Allergy, November 2013, Wiley

    Prof. John W Holloway, Professor Adnan Custovic

  202. Altered microRNA expression profile during epithelial wound repair in bronchial epithelial cells

    Article • BMC Pulmonary Medicine, November 2013, Springer Science + Business Media

    Prof. John W Holloway

  203. Faculty of 1000 evaluation for Mutation in folate metabolism causes epigenetic instability and transgenerational effects on development.

    Article • October 2013, Faculty of 1000, Ltd.

    Prof. John W Holloway

  204. Dysregulation of Complement System and CD4+ T Cell Activation Pathways Implicated in Allergic Response

    Article • PLoS ONE, October 2013, PLOS

    Prof. John W Holloway

  205. Sensitization via Healthy Skin Programs Th2 Responses in Individuals with Atopic Dermatitis

    Article • Journal of Investigative Dermatology, October 2013, Elsevier

    Prof. John W Holloway

  206. Genome-wide association studies in asthma; perhaps, the end of the beginning

    Article • Current Opinion in Allergy and Clinical Immunology, October 2013, Wolters Kluwer Health

    Prof. John W Holloway

  207. Defining the contribution of SNPs identified in asthma GWAS to clinical variables in asthmatic children

    Article • BMC Medical Genetics, September 2013, Springer Science + Business Media

    Prof. John W Holloway

  208. Faculty of 1000 evaluation for RNA interference knockdown of DNA methyl-transferase 3 affects gene alternative splicing in the honey bee.

    Article • September 2013, Faculty of 1000, Ltd.

    Prof. John W Holloway

  209. Effect of GSTM2-5polymorphisms in relation to tobacco smoke exposures on lung function growth: a birth cohort study

    Article • BMC Pulmonary Medicine, September 2013, Springer Science + Business Media

    Prof. John W Holloway

  210. Faculty of 1000 evaluation for A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci.

    Article • July 2013, Faculty of 1000, Ltd.

    Prof. John W Holloway

  211. MUC5AC and inflammatory mediators associated with respiratory outcomes in the British 1946 birth cohort

    Article • Respirology, July 2013, Wiley

    Prof. John W Holloway

  212. Interactive effect of STAT6 and IL13gene polymorphisms on eczema status: results from a longitudinal and a cross-sectional study

    Article • BMC Medical Genetics, July 2013, Springer Science + Business Media

    Prof. John W Holloway

  213. Faculty of 1000 evaluation for Adult monozygotic twins discordant for intra-uterine growth have indistinguishable genome-wide DNA methylation profiles.

    Article • June 2013, Faculty of 1000, Ltd.

    Prof. John W Holloway

  214. Faculty of 1000 evaluation for A cell epigenotype specific model for the correction of brain cellular heterogeneity bias and its application to age, brain region and major depression.

    Article • April 2013, Faculty of 1000, Ltd.

    Prof. John W Holloway

  215. HHIP,HDAC4,NCR3andRARBpolymorphisms affect fetal, childhood and adult lung function: Table 1–

    Article • European Respiratory Journal, February 2013, European Respiratory Society (ERS)

    Prof. John W Holloway

  216. Faculty of 1000 evaluation for DNA Methylation in the Neuropeptide S Receptor 1 (NPSR1) Promoter in Relation to Asthma and Environmental Factors.

    Article • February 2013, Faculty of 1000, Ltd.

    Prof. John W Holloway

  217. Validation of novel wheeze phenotypes using longitudinal airway function and atopic sensitization data in the first 6 years of life: Evidence from the Southampton Women's survey

    Article • Pediatric Pulmonology, February 2013, Wiley

    Prof. John W Holloway

  218. Epigenetic mechanisms and models in the origins of asthma

    Article • Current Opinion in Allergy and Clinical Immunology, February 2013, Wolters Kluwer Health

    Prof. John W Holloway

  219. The association of the cytoplasmic domains of interleukin 4 receptor alpha and interleukin 13 receptor alpha 2 regulates interleukin 4 signaling

    Article • Molecular BioSystems, January 2013, Royal Society of Chemistry

    Prof. John W Holloway

  220. Interaction of prenatal maternal smoking, interleukin 13 genetic variants and DNA methylation influencing airflow and airway reactivity

    Article • Clinical Epigenetics, January 2013, Springer Science + Business Media

    Prof. John W Holloway

  221. The interaction of genetic variants and DNA methylation of the interleukin-4 receptor gene increase the risk of asthma at age 18 years

    Article • Clinical Epigenetics, January 2013, Springer Science + Business Media

    Prof. John W Holloway

  222. New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism

    Article • Nature Genetics, December 2012, Springer Science + Business Media

    Professor Dorret I Boomsma, Prof. John W Holloway

  223. Leukotriene B4 receptor locus gene characterisation and association studies in asthma

    Article • BMC Medical Genetics, November 2012, Springer Science + Business Media

    Prof. John W Holloway

  224. DNA methylation of the filaggrin gene adds to the risk of eczema associated with loss-of-function variants

    Article • Journal of the European Academy of Dermatology and Venereology, September 2012, Wiley

    Prof. John W Holloway

  225. Evidence of association between interferon regulatory factor 5 gene polymorphisms and asthma

    Article • Gene, August 2012, Elsevier

    Prof. John W Holloway

  226. The effect of parental allergy on childhood allergic diseases depends on the sex of the child

    Article • Journal of Allergy and Clinical Immunology, August 2012, Elsevier

    Prof. John W Holloway

  227. Of flies, mice and men: a systematic approach to understanding the early life origins of chronic lung disease

    Article • Thorax, July 2012, BMJ

    Prof. John W Holloway

  228. Increased expression of the 5-lipoxygenase pathway and its cellular localization in Barrett’s adenocarcinoma

    Article • Histopathology, June 2012, Wiley

    Prof. John W Holloway

  229. Genome-wide association study to identify genetic determinants of severe asthma

    Article • Thorax, May 2012, BMJ

    Prof. John W Holloway

  230. Next generation exome sequencing of paediatric inflammatory bowel disease patients identifies rare and novel variants in candidate genes

    Article • Gut, April 2012, BMJ

    Prof. John W Holloway

  231. Genomics and the respiratory effects of air pollution exposure

    Article • Respirology, April 2012, Wiley

    Prof. John W Holloway

  232. Common variants at 6q22 and 17q21 are associated with intracranial volume

    Article • Nature Genetics, April 2012, Springer Science + Business Media

    Professor Dorret I Boomsma, Dr Stefan Ropele, Prof. John W Holloway, Professor Alina Rodriguez

  233. Common variants at 12q15 and 12q24 are associated with infant head circumference

    Article • Nature Genetics, April 2012, Springer Science + Business Media

    Professor Dorret I Boomsma, Dr Stefan Ropele, Prof. John W Holloway, Jari Lahti, Professor Alina Rodriguez

  234. A genome-wide association meta-analysis identifies new childhood obesity loci

    Article • Nature Genetics, April 2012, Springer Science + Business Media

    Professor Dorret I Boomsma, Prof. John W Holloway

  235. No Interactions Between Previously Associated 2-Hour Glucose Gene Variants and Physical Activity or BMI on 2-Hour Glucose Levels

    Article • Diabetes, March 2012, American Diabetes Association

    Prof. John W Holloway

  236. Interplay of Filaggrin Loss-of-Function Variants, Allergic Sensitization, and Eczema in a Longitudinal Study Covering Infancy to 18 Years of Age

    Article • PLoS ONE, March 2012, PLOS

    Prof. John W Holloway

  237. Successful grant writing

    Article • Paediatric Respiratory Reviews, March 2012, Elsevier

    Prof. John W Holloway

  238. Invited Lecture: Activation of the Epithelial Mesenchymal Trophic Unit in the Pathogenesis of Asthma

    Article • International Archives of Allergy and Immunology, January 2012, Karger Publishers

    Prof. John W Holloway

  239. Interleukin-13, but Not Indomethacin, Increases Cysteinyl-Leukotriene Synthesis in Human Lung Macrophages

    Article • Journal of Allergy, January 2012, Hindawi Publishing Corporation

    Prof. John W Holloway

  240. The genetic basis of allergy and asthma

    Article • January 2012, Elsevier

    Prof. John W Holloway

  241. Effect of Five Genetic Variants Associated with Lung Function on the Risk of Chronic Obstructive Lung Disease, and Their Joint Effects on Lung Function

    Article • American Review of Respiratory Disease, October 2011, American Thoracic Society

    Prof. John W Holloway

  242. Identification of ATPAF1 as a novel candidate gene for asthma in children

    Article • Journal of Allergy and Clinical Immunology, October 2011, Elsevier

    Prof. John W Holloway

  243. Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function

    Article • Nature Genetics, September 2011, Springer Science + Business Media

    Dr Massimo Mangino, Prof. John W Holloway

  244. Neurophysiological evidence for cognitive and brain functional adaptation in adolescents living at high altitude

    Article • Clinical Neurophysiology, September 2011, Elsevier

    Prof. John W Holloway

  245. I have taken my umbrella, so of course it does not rain: Figure 1

    Article • Thorax, August 2011, BMJ

    Prof. John W Holloway

  246. Adjusting wheal size measures to correct atopy misclassification

    Article • International Journal of General Medicine, August 2011, Taylor & Francis

    Mr JIANJUN GAN, Prof. John W Holloway

  247. Relationship of vitamin D status to adult lung function and COPD

    Article • Thorax, June 2011, BMJ

    Prof. John W Holloway

  248. A genome-wide association study to identify genetic determinants of atopy in subjects from the United Kingdom

    Article • Journal of Allergy and Clinical Immunology, January 2011, Elsevier

    Prof. John W Holloway

  249. Prenatal and infant acetaminophen exposure, antioxidant gene polymorphisms, and childhood asthma

    Article • Journal of Allergy and Clinical Immunology, December 2010, Elsevier

    Prof. John W Holloway

  250. A Large-Scale, Consortium-Based Genomewide Association Study of Asthma

    Article • New England Journal of Medicine, September 2010, New England Journal of Medicine (NEJM/MMS)

    Prof. Dr. med. Jon Genuneit, Prof. John W Holloway, Miriam Moffatt

  251. The relationship between infant lung function and the risk of wheeze in the preschool years

    Article • Pediatric Pulmonology, September 2010, Wiley

    Prof. John W Holloway

  252. The Role of Histamine Degradation Gene Polymorphisms in Moderating the Effects of Food Additives on Children's ADHD Symptoms

    Article • American Journal of Psychiatry, September 2010, American Psychiatric Association

    Prof. John W Holloway

  253. Maternal Nrf2 and gluthathione-S-transferase polymorphisms do not modify associations of prenatal tobacco smoke exposure with asthma and lung function in school-aged children

    Article • Thorax, August 2010, BMJ

    Prof. John W Holloway

  254. Using genetics to predict the natural history of asthma?

    Article • Journal of Allergy and Clinical Immunology, August 2010, Elsevier

    Prof. John W Holloway

  255. ADAM33 expression in atherosclerotic lesions and relationship of ADAM33 gene variation with atherosclerosis

    Article • Atherosclerosis, July 2010, Elsevier

    Prof. John W Holloway

  256. Development of aptitude at altitude

    Article • Developmental Science, May 2010, Wiley

    Prof. John W Holloway

  257. Genetic polymorphisms in the endotoxin receptor may influence platelet count as part of the acute phase response in critically ill children

    Article • Intensive Care Medicine, March 2010, Springer Science + Business Media

    Prof. John W Holloway

  258. Genetics of allergic disease

    Article • Journal of Allergy and Clinical Immunology, February 2010, Elsevier

    Prof. John W Holloway

  259. Alpha Tryptase: Potential Roles in Inflammation Distinct from those of β-tryptase

    Article • Journal of Allergy and Clinical Immunology, February 2010, Elsevier

    Dr Mogibelrahman Khedr, Prof. John W Holloway

  260. The Genetics of Allergic Disease and Asthma

    Article • January 2010, Elsevier

    Prof. John W Holloway

  261. Glutathione-S-transferase genes and asthma phenotypes: a Human Genome Epidemiology (HuGE) systematic review and meta-analysis including unpublished data

    Article • International Journal of Epidemiology, December 2009, Oxford University Press (OUP)

    Prof. John W Holloway

  262. Genome-wide association study identifies five loci associated with lung function

    Article • Nature Genetics, December 2009, Springer Science + Business Media

    Dr Massimo Mangino, Prof. John W Holloway

  263. Identification of PCDH1 as a Novel Susceptibility Gene for Bronchial Hyperresponsiveness

    Article • American Review of Respiratory Disease, November 2009, American Thoracic Society

    Prof. John W Holloway

  264. Atopy susceptibility and chromosome 19q13

    Article • Allergy, November 2009, Wiley

    Prof. John W Holloway

  265. Mortality in adult intensive care patients with severe systemic inflammatory response syndromes is strongly associated with the hypo-immune TNF −238A polymorphism

    Article • Immunogenetics, August 2009, Springer Science + Business Media

    Prof. John W Holloway

  266. Contribution of functional variation in theIL13gene to allergy, hay fever and asthma in the NSHD longitudinal 1946 birth cohort

    Article • Allergy, August 2009, Wiley

    Prof. John W Holloway

  267. Cytoplasmic tail of IL-13Rα2 regulates IL-4 signal transduction

    Article • Biochemical Society Transactions, August 2009, Portland Press Ltd.

    Prof. John W Holloway

  268. Genetic susceptibility to the respiratory effects of air pollution

    Article • Postgraduate Medical Journal, July 2009, BMJ

    Prof. John W Holloway

  269. Copy-Number Variation Genotyping of GSTT1 and GSTM1 Gene Deletions by Real-Time PCR

    Article • Clinical Chemistry, July 2009, AACC

    Prof. John W Holloway

  270. Genome-Wide Association Scan Meta-Analysis Identifies Three Loci Influencing Adiposity and Fat Distribution

    Article • PLoS Genetics, June 2009, PLOS

    Dr Massimo Mangino, Prof. John W Holloway

  271. PLAUR polymorphisms are associated with asthma, PLAUR levels, and lung function decline

    Article • Journal of Allergy and Clinical Immunology, June 2009, Elsevier

    Prof. John W Holloway

  272. Human mid-gestation amniotic fluid contains interleukin-16 bioactivity

    Article • Immunology, April 2009, Wiley

    Prof. John W Holloway

  273. Copy Number Variation at Loci for α- and β-Tryptases: Associations with the Asthma Phenotype.

    Article • April 2009, American Thoracic Society

    Prof. John W Holloway

  274. Association Analysis of Brain-Derived Neurotrophic Factor Gene Polymorphisms in Asthmatic Families

    Article • International Archives of Allergy and Immunology, March 2009, Karger Publishers

    Prof. John W Holloway

  275. Chronological expression of Ciliated Bronchial Epithelium 1 during pulmonary development

    Article • European Respiratory Journal, February 2009, European Respiratory Society (ERS)

    Prof. John W Holloway

  276. Effect of β2-Adrenergic Receptor Polymorphism in Asthma Control of Patients Receiving Combination Treatment

    Article • Yonsei Medical Journal, January 2009, Yonsei University College of Medicine (KAMJE)

    Prof. John W Holloway

  277. 17q21 Variants and Asthma — Questions and Answers

    Article • New England Journal of Medicine, November 2008, New England Journal of Medicine (NEJM/MMS)

    Prof. John W Holloway

  278. A single-nucleotide polymorphism in intelectin 1 is associated with increased asthma risk

    Article • Journal of Allergy and Clinical Immunology, November 2008, Elsevier

    Prof. John W Holloway

  279. The role ofLTA4HandALOX5APpolymorphism in asthma and allergy susceptibility

    Article • Allergy, August 2008, Wiley

    Prof. John W Holloway

  280. Epigenetic mechanisms silence a disintegrin and metalloprotease 33 expression in bronchial epithelial cells

    Article • Journal of Allergy and Clinical Immunology, June 2008, Elsevier

    Prof. John W Holloway

  281. Interpatient variability in rates of asthma progression: Can genetics provide an answer?

    Article • Journal of Allergy and Clinical Immunology, March 2008, Elsevier

    Prof. John W Holloway

  282. Asthma: advancing gene?environment studies

    Article • Clinical & Experimental Allergy, September 2007, Wiley

    Prof. John W Holloway

  283. Effect of IL-13 receptor α2 levels on the biological activity of IL-13 variant R110Q

    Article • Journal of Allergy and Clinical Immunology, July 2007, Elsevier

    Prof. John W Holloway

  284. Genetic association studies of interleukin-13 receptor  1 subunit gene polymorphisms in asthma and atopy

    Article • European Respiratory Journal, March 2007, European Respiratory Society (ERS)

    Prof. John W Holloway

  285. Association between a TGFβ1 promoter polymorphism and rhinosinusitis in aspirin-intolerant asthmatic patients

    Article • Respiratory Medicine, March 2007, Elsevier

    Prof. John W Holloway

  286. Gene–environmental interaction in asthma

    Article • Current Opinion in Allergy and Clinical Immunology, February 2007, Wolters Kluwer Health

    Prof. John W Holloway

  287. Identifying novel genes contributing to asthma pathogenesis

    Article • Current Opinion in Allergy and Clinical Immunology, February 2007, Wolters Kluwer Health

    Prof. John W Holloway

  288. Local genetic and environmental factors in asthma disease pathogenesis: chronicity and persistence mechanisms

    Article • European Respiratory Journal, January 2007, European Respiratory Society (ERS)

    Prof. John W Holloway

  289. Association of TNF-? genetic polymorphism with HLA DPB1*0301

    Article • Clinical & Experimental Allergy, October 2006, Wiley

    Prof. John W Holloway

  290. IL-13 receptor α 2: A regulator of IL-13 and IL-4 signal transduction in primary human fibroblasts

    Article • Journal of Allergy and Clinical Immunology, October 2006, Elsevier

    Prof. John W Holloway

  291. A polymorphism of MS4A2 (-109T>C) encoding the beta-chain of the high-affinity immunoglobulin E receptor (FceR1beta) is associated with a susceptibility to aspirin-intolerant asthma

    Article • Clinical & Experimental Allergy, July 2006, Wiley

    Prof. John W Holloway

  292. MUC7 Haplotype Analysis: Results from a Longitudinal Birth Cohort Support Protective Effect of the MUC7*5 Allele on Respiratory Function

    Article • Annals of Human Genetics, July 2006, Wiley

    Prof. John W Holloway

  293. The Genetics of Asthma: ADAM33 as an Example of a Susceptibility Gene

    Article • Proceedings of the American Thoracic Society, July 2006, American Thoracic Society

    Prof. John W Holloway

  294. IL-4 Receptor   Is an Important Modulator of IL-4 and IL-13 Receptor Binding: Implications for the Development of Therapeutic Targets

    Article • The Journal of Immunology, June 2006, The American Association of Immunologists

    Prof. John W Holloway

  295. The cysteinyl-leukotriene type 1 receptor polymorphism 927T/C is associated with atopy severity but not with asthma

    Article • Clinical & Experimental Allergy, June 2006, Wiley

    Prof. John W Holloway

  296. Understanding the pathophysiology of severe asthma to generate new therapeutic opportunities

    Article • Journal of Allergy and Clinical Immunology, March 2006, Elsevier

    Prof. John W Holloway

  297. ADAM33: a newly identified protease involved in airway remodelling

    Article • Pulmonary Pharmacology & Therapeutics, February 2006, Elsevier

    Prof. John W Holloway

  298. The role of Toll-like receptors and related receptors of the innate immune system in asthma

    Article • Current Opinion in Allergy and Clinical Immunology, February 2006, Wolters Kluwer Health

    Prof. John W Holloway

  299. Association of asthma with a functional promoter polymorphism in the IL16 gene

    Article • Journal of Allergy and Clinical Immunology, January 2006, Elsevier

    Prof. John W Holloway

  300. ADAM33: A Newly Identified Gene in the Pathogenesis of Asthma

    Article • Immunology and Allergy Clinics of North America, November 2005, Elsevier

    Prof. John W Holloway

  301. Tissue localization and frequency of antigen-specific effector CD4+ T cells determines the development of allergic airway inflammation

    Article • Immunology and Cell Biology, October 2005, Nature

    Prof. John W Holloway

  302. Polymorphisms in A Disintegrin and Metalloprotease 33 ( ADAM33 ) Predict Impaired Early-Life Lung Function

    Article • American Review of Respiratory Disease, July 2005, American Thoracic Society

    Prof. John W Holloway, Professor Adnan Custovic

  303. Polymorphism of tandem repeat in promoter of 5-lipoxygenase in ASA-intolerant asthma: a positive association with airway hyperresponsiveness

    Article • Allergy, June 2005, Wiley

    Prof. John W Holloway

  304. β-Catenin/T-cell factor-mediated transcription is modulated by cell density in human bronchial epithelial cells

    Article • The International Journal of Biochemistry & Cell Biology, June 2005, Elsevier

    Prof. John W Holloway

  305. Association of thromboxane A2 receptor gene polymorphism with the phenotype of acetyl salicylic acid-intolerant asthma

    Article • Clinical & Experimental Allergy, May 2005, Wiley

    Prof. John W Holloway

  306. β-Adrenergic receptor polymorphism and asthma: True or false?

    Article • Journal of Allergy and Clinical Immunology, May 2005, Elsevier

    Prof. John W Holloway

  307. Is big beautiful? The continuing story of ADAM33 and asthma

    Article • Thorax, April 2005, BMJ

    Prof. John W Holloway

  308. Association of Tumor Necrosis Factor-α Polymorphisms and Ozone-induced Change in Lung Function

    Article • American Review of Respiratory Disease, January 2005, American Thoracic Society

    Prof. John W Holloway

  309. Identification and Function of a Novel Candidate Gene for Asthma:ADAM 33

    Article • Allergology International, January 2005, Japanese Society of Allergology

    Prof. John W Holloway

  310. Identification and possible functions of ADAM33 as an asthma susceptibility gene

    Article • Clinical & Experimental Allergy Reviews, December 2004, Wiley

    Prof. John W Holloway

  311. Characterization of Ciliated Bronchial Epithelium 1, a Ciliated Cell–Associated Gene Induced During Mucociliary Differentiation

    Article • American Journal of Respiratory Cell and Molecular Biology, November 2004, American Thoracic Society

    Prof. John W Holloway

  312. World Allergy Organization Guidelines for Prevention of Allergy and Allergic Asthma

    Article • International Archives of Allergy and Immunology, September 2004, Karger Publishers

    Prof. John W Holloway, Professor Adnan Custovic

  313. The discovery and role of ADAM33, a new candidate gene for asthma

    Article • Expert Reviews in Molecular Medicine, August 2004, Cambridge University Press

    Prof. John W Holloway

  314. Polymorphism of the mast cell chymase gene (CMA1) promoter region: lack of association with asthma but association with serum total immunoglobulin E levels in adult atopic dermatitis

    Article • Clinical & Experimental Allergy, July 2004, Wiley

    Prof. John W Holloway

  315. The Splicing and Fate of ADAM33 Transcripts in Primary Human Airways Fibroblasts

    Article • American Journal of Respiratory Cell and Molecular Biology, July 2004, American Thoracic Society

    Prof. John W Holloway

  316. ADAM33 polymorphism: association with bronchial hyper-responsiveness in Korean asthmatics

    Article • Clinical & Experimental Allergy, June 2004, Wiley

    Prof. John W Holloway

  317. Epithelial-Mesenchymal Communication in the Pathogenesis of Chronic Asthma

    Article • Proceedings of the American Thoracic Society, April 2004, American Thoracic Society

    Prof. John W Holloway

  318. Erratum to“TLR4 Asp299Gly polymorphism is not associated with coronary artery stenosis” [ATH 170 (2003) 187–190]

    Article • Atherosclerosis, March 2004, Elsevier

    Prof. John W Holloway

  319. The role of ADAM33 in the pathogenesis of asthma

    Article • Springer Seminars in Immunopathology, February 2004, Springer Science + Business Media

    Prof. John W Holloway

  320. Toll-like receptor polymorphisms and allergic disease: interpreting the evidence from genetic studies

    Article • Clinical & Experimental Allergy, February 2004, Wiley

    Prof. John W Holloway

  321. Lack of association of HLA class I genes and TNF alpha-308 polymorphism in toluene diisocyanate-induced asthma

    Article • Allergy, January 2004, Wiley

    Prof. John W Holloway

  322. Toll-like receptor 4 polymorphism and severity of atopy in asthmatics

    Article • Genes & Immunity, January 2004, Nature

    Prof. John W Holloway

  323. World Allergy Organization Guidelines for Prevention of Allergy and Allergic Asthma

    Article • Allergy & Clinical Immunology International - Journal of the World Allergy Organization, January 2004, Hogrefe Publishing Group

    Prof. John W Holloway, Professor Adnan Custovic

  324. Genetics

    Article • January 2004, Karger Publishers

    Prof. John W Holloway

  325. TLR4 Asp299Gly polymorphism is not associated with coronary artery stenosis

    Article • Atherosclerosis, September 2003, Elsevier

    Prof. John W Holloway

  326. ADAM33: a novel therapeutic target for asthma

    Article • Expert Opinion on Therapeutic Targets, August 2003, Informa Healthcare

    Prof. John W Holloway

  327. Polymorphisms in the interleukin-4 and interleukin-4 receptor alpha chain genes confer susceptibility to asthma and atopy in a Caucasian population

    Article • Clinical & Experimental Allergy, August 2003, Wiley

    Prof. John W Holloway

  328. Promoter polymorphism in the 5-lipoxygenase (ALOX5) and 5-lipoxygenase-activating protein (ALOX5AP) genes and asthma susceptibility in a Caucasian population

    Article • Clinical & Experimental Allergy, August 2003, Wiley

    Prof. John W Holloway

  329. ADAM 33: just another asthma gene or a breakthrough in understanding the origins of bronchial hyperresponsiveness?

    Article • Thorax, June 2003, BMJ

    Prof. John W Holloway

  330. Polymorphisms in Toll-like receptor 4 and the systemic inflammatory response syndrome

    Article • Biochemical Society Transactions, June 2003, Portland Press Ltd.

    Prof. John W Holloway

  331. Allelic association and functional studies of promoter polymorphism in the leukotriene C4 synthase gene (LTC4S) in asthma

    Article • Thorax, May 2003, BMJ

    Prof. John W Holloway

  332. Assessment of White Blood Cell Phagocytosis as an Immunological Indicator of Methylmercury Exposure in Birds

    Article • Archives of Environmental Contamination and Toxicology, May 2003, Springer Science + Business Media

    Prof. John W Holloway

  333. Kinetic Analysis of the Interleukin-13 Receptor Complex

    Article • Journal of Biological Chemistry, September 2002, American Society for Biochemistry & Molecular Biology (ASBMB)

    Prof. John W Holloway

  334. Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness

    Article • Nature, July 2002, Nature

    Prof. John W Holloway

  335. Cooperative Effects of Th2 Cytokines and Allergen on Normal and Asthmatic Bronchial Epithelial Cells

    Article • The Journal of Immunology, July 2002, The American Association of Immunologists

    Prof. John W Holloway

  336. Reduced soluble CD14 levels in amniotic fluid and breast milk are associated with the subsequent development of atopy, eczema, or both

    Article • Journal of Allergy and Clinical Immunology, May 2002, Elsevier

    Prof. John W Holloway

  337. Meta-analysis for linkage to asthma and atopy in the chromosome 5q31-33 candidate region

    Article • Human Molecular Genetics, April 2001, Oxford University Press (OUP)

    Prof. John W Holloway

  338. Linkage analysis of the 5q31–33 candidate region for asthma in 240 UK families

    Article • Genes & Immunity, February 2001, Nature

    Prof. John W Holloway

  339. A retrospective collaboration on chromosome 5 by the International Consortium on Asthma Genetics (COAG)

    Article • Clinical & Experimental Allergy, January 2001, Wiley

    Prof. John W Holloway

  340. Variant LTC4 synthase allele modifies cysteinyl leukotriene synthesis in eosinophils and predicts clinical response to zafirlukast

    Article • Thorax, October 2000, BMJ

    Prof. John W Holloway

  341. A first trial of retrospective collaboration for positional cloning in complex inheritance: Assay of the cytokine region on chromosome 5 by the Consortium on Asthma Genetics (COAG)

    Article • Proceedings of the National Academy of Sciences, September 2000, Proceedings of the National Academy of Sciences

    Prof. John W Holloway

  342. Association of beta2-adrenergic receptor polymorphisms with severe asthma

    Article • Clinical & Experimental Allergy, August 2000, Wiley

    Prof. John W Holloway

  343. Comparison of three methods for single nucleotide polymorphism typing for DNA bank studies: Sequence-specific oligonucleotide probe hybridisation, TaqMan liquid phase hybridisation, and microplate array diagonal gel electrophoresis (MADGE)

    Article • Human Mutation, October 1999, Wiley

    Prof. John W Holloway

  344. Interleukin-12 and allergic tissue response

    Article • Clinical & Experimental Allergy, October 1999, Wiley

    Prof. John W Holloway

  345. The genetic basis of atopic asthma

    Article • Clinical & Experimental Allergy, August 1999, Wiley

    Prof. John W Holloway

  346. Infection of Mice withMycobacterium bovis–Bacillus Calmette-Guérin (BCG) Suppresses Allergen-induced Airway Eosinophilia

    Article • The Journal of Experimental Medicine, February 1998, Rockefeller University Press

    Prof. John W Holloway

  347. Lack of evidence of a significant association between HLA-DR, DQ and DP genotypes and atopy in families with HDM allergy

    Article • Clinical & Experimental Allergy, October 1996, Wiley

    Prof. John W Holloway

  348. Innate immunity: Mast cells in the front line

    Article • Current Biology, August 1996, Elsevier

    Prof. John W Holloway

  349. Genetics of Asthma: What's New?

    Article • Wiley

    Prof. John W Holloway

  350. Genetics of Asthma and Bronchial Hyperresponsiveness

    Article • Springer Science + Business Media

    Prof. John W Holloway