All Stories

  1. Measurement of carotid plaque burden

    Article • January 2025, Elsevier

    Prof. J. David Spence

  2. Letter to the Editor From Spence: [Prevalence and Characteristics of Low-Renin Hypertension in a Primary Care Population]

    Article • Journal of the Endocrine Society, August 2024, Endocrine Society

    Prof. J. David Spence

  3. Homocysteine and Myocardial Injury

    Article • JACC Asia, August 2024, Elsevier

    Prof. J. David Spence

  4. Correspondence on: “Subclinical atherosclerosis: More data – More insights into prevention”

    Article • Atherosclerosis, August 2024, Elsevier

    Prof. J. David Spence

  5. Reducing Cardiovascular Risk: The Potential of Plant-Based Meat Alternatives and Egg Substitutes

    Article • Canadian Journal of Cardiology, July 2024, Elsevier

    Prof. J. David Spence

  6. Poor Results with “Best Medical Therapy” in Patients with Asymptomatic Carotid Stenosis

    Article • Annals of Vascular Surgery, June 2024, Elsevier

    Prof. J. David Spence

  7. Vessel Wall Volume and Plaque Volume Should Replace Carotid Intima–Media Thickness

    Article • American Journal of Hypertension, January 2024, Oxford University Press (OUP)

    Prof. J. David Spence

  8. Prior-knowledge Embedded U-Net based Fully Automatic Vessel Wall Volume Measurement of the Carotid Artery in 3D Ultrasound Image

    Article • IEEE Transactions on Medical Imaging, January 2024, Institute of Electrical & Electronics Engineers (IEEE)

    Prof. J. David Spence

  9. Carotid Plaque Burden Is a Stronger Predictor of Cardiovascular Risk Than IMT

    Article • Journal of the American College of Cardiology, November 2022, Elsevier

    Prof. J. David Spence

  10. Vertebrobasilar ischemia: Some less recognized aspects

    Article • International Journal of Stroke, October 2022, SAGE Publications

    Prof. J. David Spence

  11. Cerebrovascular Disease, Cardiovascular Disease, and Chronic Kidney Disease: Interplays and Influences

    Article • Current Neurology and Neuroscience Reports, October 2022, Springer Science + Business Media

    Prof. J. David Spence

  12. Homocysteine and Thrombophilia in Pulmonary Hypertension

    Article • JACC Asia, October 2022, Elsevier

    Prof. J. David Spence

  13. Cardiovascular effects of TMAO and other toxic metabolites of the intestinal microbiome

    Article • Journal of Internal Medicine, September 2022, Wiley

    Prof. J. David Spence

  14. Acetaminophen, Nonsteroidal Anti-Inflammatory Drugs, and Hypertension

    Article • Hypertension, September 2022, Wolters Kluwer Health

    Prof. J. David Spence

  15. In Memoriam: Jim Toole, MD: Ahead of His Time

    Article • Stroke, September 2022, Wolters Kluwer Health

    Prof. J. David Spence

  16. B vitamins for NASH: use methylcobalamin, not cyanocobalamin

    Article • Journal of Hepatology, August 2022, Elsevier

    Prof. J. David Spence

  17. Problem in the Recent American Heart Association Guideline on Secondary Stroke Prevention: B Vitamins to Lower Homocysteine Do Prevent Stroke

    Article • Stroke, June 2022, Wolters Kluwer Health

    Prof. J. David Spence

  18. Identifying High-Risk Nonstenotic Carotid Artery Disease

    Article • JACC Cardiovascular Imaging, June 2022, Elsevier

    Prof. J. David Spence

  19. Management of Patients with Embolic Stroke of Unknown Source: Interpreting the Evidence in the Light of Clinical Judgement

    Article • Current Neurology and Neuroscience Reports, May 2022, Springer Science + Business Media

    Prof. J. David Spence

  20. Efficacy of Lower Doses of Pioglitazone after Stroke or Transient Ischemic Attack In Patients with Insulin Resistance

    Article • Diabetes Obesity and Metabolism, March 2022, Wiley

    Prof. J. David Spence

  21. Fasting lipids are not a good way to assess the effects of diet on cardiovascular risk

    Article • Atherosclerosis, November 2021, Elsevier

    Prof. J. David Spence

  22. How to identify which patients should not have a systolic blood pressure target of <120 mmHg

    Article • European Heart Journal, September 2021, Oxford University Press (OUP)

    Prof. J. David Spence

  23. Deep Learning-Based Measurement of Total Plaque Area in B-Mode Ultrasound Images

    Article • IEEE Journal of Biomedical and Health Informatics, August 2021, Institute of Electrical & Electronics Engineers (IEEE)

    Prof. J. David Spence

  24. Roadmap Consensus on Carotid Artery Plaque Imaging and Impact on Therapy Strategies and Guidelines: An International, Multispecialty, Expert Review and Position Statement

    Article • American Journal of Neuroradiology, July 2021, American Society of Neuroradiology (ASNR)

    Prof. J. David Spence

  25. CONNed in Pregnancy

    Article • Hypertension, July 2021, Wolters Kluwer Health

    Prof. J. David Spence

  26. Physiological Treatment of Hypertension in Black Patients: Time for Action

    Article • Circulation, June 2021, Wolters Kluwer Health

    Prof. J. David Spence

  27. Sex differences in the intestinal microbiome: interactions with risk factors for atherosclerosis and cardiovascular disease

    Article • Biology of Sex Differences, May 2021, Springer Science + Business Media

    Prof. J. David Spence

  28. Triglyceride/High‐Density Lipoprotein Cholesterol Ratio: A Clue to Metabolic Syndrome, Insulin Resistance, and Severe Atherosclerosis

    Article • Lipids, April 2021, Wiley

    Prof. J. David Spence

  29. Renovascular Hypertension

    Article • Hypertension, April 2021, Wolters Kluwer Health

    Prof. J. David Spence

  30. Cardiovascular Harm From Egg Yolk and Meat: More Than Just Cholesterol and Saturated Fat

    Article • Journal of the American Heart Association, March 2021, Wolters Kluwer Health

    Prof. J. David Spence

  31. It's time to stop the nonsense of withholding lipid lowering therapy on account of age

    Article • Atherosclerosis, February 2021, Elsevier

    Prof. J. David Spence

  32. Measurement of carotid plaque burden: A tool for predicting and preventing dementia?

    Article • Cerebral Circulation - Cognition and Behavior, January 2021, Elsevier

    Prof. J. David Spence

  33. Stroke Prevention: Little-Known and Neglected Aspects

    Article • Cerebrovascular Diseases, January 2021, Karger Publishers

    Prof. J. David Spence

  34. Reducing the Risk of Stroke in Patients with Impaired Renal Function: Nutritional Issues

    Article • Journal of Stroke and Cerebrovascular Diseases, November 2020, Elsevier

    Prof. J. David Spence

  35. Stroke Prevention in Older Adults

    Article • Stroke, October 2020, Wolters Kluwer Health

    Prof. J. David Spence

  36. A Voxel-Based Fully Convolution Network and Continuous Max-Flow for Carotid Vessel-Wall-Volume Segmentation From 3D Ultrasound Images

    Article • IEEE Transactions on Medical Imaging, September 2020, Institute of Electrical & Electronics Engineers (IEEE)

    Prof. J. David Spence

  37. IMT is not atherosclerosis

    Article • Atherosclerosis, September 2020, Elsevier

    Prof. J. David Spence

  38. China Stroke Statistics 2019: a wealth of opportunities for stroke prevention

    Article • Stroke and Vascular Neurology, August 2020, BMJ

    Prof. J. David Spence

  39. Recent advances in preventing recurrent stroke

    Article • F1000Research, August 2020, Faculty of 1000, Ltd.

    Prof. J. David Spence

  40. New Canadian guideline is wrong to say acetylsalicylic acid is only for patients with symptomatic vascular disease

    Article • Canadian Medical Association Journal, June 2020, Canadian Medical Association (CMA)

    Prof. J. David Spence

  41. Achieving blood pressure control targets in hypertensive patients of rural China – a pilot randomized trial

    Article • Trials, June 2020, Springer Science + Business Media

    Prof. J. David Spence

  42. Risk from low blood pressure in frail older adults: diastolic pressure and pulse pressure are important

    Article • Age and Ageing, June 2020, Oxford University Press (OUP)

    Prof. J. David Spence

  43. Stroke Prevention

    Article • Stroke, June 2020, Wolters Kluwer Health

    Prof. J. David Spence

  44. Interaction of smoking, hyperhomocysteinemia and metabolic syndrome with carotid atherosclerosis: A cross sectional study in 972 non-diabetic patients

    Article • Nutrition, May 2020, Elsevier

    Prof. J. David Spence

  45. Traffic‐Related Air Pollution and Carotid Plaque Burden in a Canadian City With Low‐Level Ambient Pollution

    Article • Journal of the American Heart Association, April 2020, Wolters Kluwer Health

    Prof. J. David Spence

  46. Impaired Renal Function and Cerebrovascular Disease

    Article • Angiology, April 2020, SAGE Publications

    Prof. J. David Spence

  47. Triglyceride lowering drugs: not just icosapent ethyl

    Article • European Heart Journal, March 2020, Oxford University Press (OUP)

    Prof. J. David Spence

  48. Adding Insight to Injury!

    Article • European Journal of Vascular and Endovascular Surgery, March 2020, Elsevier

    Prof. J. David Spence

  49. Effect of Vitamin B12 Levels on the Association Between Folic Acid Treatment and CKD Progression: A Post Hoc Analysis of a Folic Acid Interventional Trial

    Article • American Journal of Kidney Diseases, March 2020, Elsevier

    Prof. J. David Spence

  50. Lower risk of stroke with a vegetarian diet

    Article • Neurology, February 2020, Wolters Kluwer Health

    Prof. J. David Spence

  51. Choosing the right therapy for a patient with asymptomatic carotid stenosis

    Article • Expert Review of Cardiovascular Therapy, February 2020, Taylor & Francis

    Prof. J. David Spence

  52. Patent foramen ovale in patients with atrial fibrillation

    Article • International Journal of Cardiology, February 2020, Elsevier

    Prof. J. David Spence

  53. Three-dimensional ultrasound evaluation of the effects of pomegranate therapy on carotid plaque texture using locality preserving projection

    Article • Computer Methods and Programs in Biomedicine, February 2020, Elsevier

    Prof. J. David Spence

  54. Interaction of serum vitamin B12 and folate with MTHFR genotypes on risk of ischemic stroke

    Article • Neurology, January 2020, Wolters Kluwer Health

    Prof. J. David Spence

  55. Rationale for screening selected patients for asymptomatic carotid artery stenosis

    Article • Current Medical Research and Opinion, January 2020, Taylor & Francis

    Prof. J. David Spence

  56. Asymptomatic Carotid Stenosis: High Risk With Suboptimal Treatment

    Article • European Journal of Vascular and Endovascular Surgery, January 2020, Elsevier

    Prof. J. David Spence

  57. Longitudinal assessment of carotid plaque texture in three-dimensional ultrasound images based on semi-supervised graph-based dimensionality reduction and feature selection

    Article • Computers in Biology and Medicine, January 2020, Elsevier

    Prof. J. David Spence

  58. Mechanisms of Stroke in COVID-19

    Article • Cerebrovascular Diseases, January 2020, Karger Publishers

    Prof. J. David Spence

  59. The need for clinical judgement in the application of evidence-based medicine

    Article • BMJ evidence-based medicine, December 2019, BMJ

    Prof. J. David Spence

  60. Chili Pepper Consumption and Cardiovascular Mortality

    Article • Journal of the American College of Cardiology, December 2019, Elsevier

    Prof. J. David Spence

  61. Resistant Hypertension

    Article • Endocrinology and Metabolism Clinics of North America, December 2019, Elsevier

    Prof. J. David Spence

  62. Socioeconomic status and stroke incidence, prevalence, mortality, and worldwide burden: an ecological analysis from the Global Burden of Disease Study 2017

    Article • BMC Medicine, October 2019, Springer Science + Business Media

    Prof. J. David Spence

  63. Trimethylamine N-oxide: not just red meat—egg yolk and renal function are also important

    Article • European Heart Journal, October 2019, Oxford University Press (OUP)

    Prof. J. David Spence

  64. Carotid Intima–Media Thickness Versus Carotid Plaque Burden for Predicting Cardiovascular Risk

    Article • Angiology, September 2019, SAGE Publications

    Prof. J. David Spence

  65. Interpreting stimulated plasma renin and aldosterone to select physiologically individualized therapy for resistant hypertension: importance of the class of stimulating drugs

    Article • Hypertension Research, September 2019, Springer Science + Business Media

    Prof. J. David Spence

  66. Registration of amiloride in South Africa: Cutting the Gordian knot

    Article • South African Medical Journal, August 2019, Health and Medical Publishing Group

    Prof. J. David Spence

  67. Statins for Primary Prevention of Cardiovascular Disease

    Article • Annals of Internal Medicine, July 2019, American College of Physicians

    Prof. J. David Spence

  68. Deep learning‐based carotid media‐adventitia and lumen‐intima boundary segmentation from three‐dimensional ultrasound images

    Article • Medical Physics, June 2019, Wiley

    Prof. J. David Spence

  69. Coronary calcium is not all we need: Carotid plaque burden measured by ultrasound is better

    Article • Atherosclerosis, April 2019, Elsevier

    Prof. J. David Spence

  70. Periprocedural events dominate outcomes of carotid stenting and endarterectomy

    Article • The Lancet Neurology, April 2019, Elsevier

    Prof. J. David Spence

  71. Nutrition and Risk of Stroke

    Article • Nutrients, March 2019, MDPI AG

    Prof. J. David Spence

  72. The Importance of Blood Pressure Gradients in the Brain

    Article • JAMA Neurology, March 2019, American Medical Association (AMA)

    Prof. J. David Spence

  73. Antiplatelet Therapy in Ischemic Stroke and Transient Ischemic Attack

    Article • Stroke, March 2019, Wolters Kluwer Health

    Prof. J. David Spence

  74. Pioglitazone Therapy in Patients With Stroke and Prediabetes

    Article • JAMA Neurology, February 2019, American Medical Association (AMA)

    Prof. J. David Spence

  75. Blood Pressure Gradients in the Brain: Their Importance to Understanding Pathogenesis of Cerebral Small Vessel Disease

    Article • Brain Sciences, January 2019, MDPI AG

    Prof. J. David Spence

  76. Anticoagulation in patients with Embolic Stroke of Unknown Source

    Article • International Journal of Stroke, January 2019, SAGE Publications

    Prof. J. David Spence

  77. Vitamin B12 deficiency and hyperhomocysteinaemia in outpatients with stroke or transient ischaemic attack: a cohort study at an academic medical centre

    Article • BMJ Open, January 2019, BMJ

    Prof. J. David Spence

  78. Increased carotid plaque burden in patients with family medical history of premature cardiovascular events in the absence of classical risk factors

    Article • Archives of Medical Science, January 2019, Termedia Sp. z.o.o.

    Prof. J. David Spence

  79. Hypertension in Africa

    Article • European Journal of Preventive Cardiology, December 2018, SAGE Publications

    Prof. J. David Spence

  80. Decline in the Severity of Carotid Atherosclerosis and Associated Risk Factors From 2002 to 2014

    Article • Stroke, November 2018, Wolters Kluwer Health

    Prof. J. David Spence

  81. Harm With High Levels of Serum B12 in Elderly Persons

    Article • The Journals of Gerontology Series A, October 2018, Oxford University Press (OUP)

    Prof. J. David Spence

  82. Cardiovascular benefit of egg consumption is most unlikely

    Article • Heart, October 2018, BMJ

    Prof. J. David Spence

  83. Advances in Stroke Prevention

    Article • Journal of Translational Internal Medicine, October 2018, De Gruyter

    Prof. J. David Spence

  84. Elevated level of lecithin:cholesterol acyltransferase (LCAT) is associated with reduced coronary atheroma burden

    Article • Atherosclerosis, September 2018, Elsevier

    Prof. J. David Spence

  85. Rivaroxaban or aspirin for patent foramen ovale and embolic stroke of undetermined source: a prespecified subgroup analysis from the NAVIGATE ESUS trial

    Article • The Lancet Neurology, September 2018, Elsevier

    Dr Giacomo Della Marca, Prof. J. David Spence, M.D Ph.D Serge Timsit, MD; PhD José L. Hernández , Director of the stroke unit, DMSci, clinical research associate professor Helle K. Iversen

  86. Data on the gut and saliva microbiota from a cohort of atherosclerosis patients determined by 16S rRNA gene sequencing

    Article • Data in Brief, August 2018, Elsevier

    Prof. J. David Spence

  87. Moderate Renal Impairment and Toxic Metabolites Produced by the Intestinal Microbiome: Dietary Implications

    Article • August 2018, Elsevier

    Prof. J. David Spence

  88. Hypertension in Blacks

    Article • Hypertension, August 2018, Wolters Kluwer Health

    Prof. J. David Spence

  89. Fractal dimension based carotid plaque characterization from three-dimensional ultrasound images

    Article • Medical & Biological Engineering & Computing, July 2018, Springer Science + Business Media

    Prof. J. David Spence

  90. Mediterranean Diet Score: Associations with Metabolic Products of the Intestinal Microbiome, Carotid Plaque Burden, and Renal Function

    Article • Nutrients, June 2018, MDPI AG

    Prof. J. David Spence

  91. Stroke Prevention: Editorial to accompany June issue of SVN

    Article • Stroke and Vascular Neurology, June 2018, BMJ

    Prof. J. David Spence

  92. [18F]-Fluorodeoxyglucose PET/CT imaging as a marker of carotid plaque inflammation: Comparison to immunohistology and relationship to acuity of events

    Article • International Journal of Cardiology, June 2018, Elsevier

    Prof. J. David Spence

  93. Egg Consumption and Cardiovascular Risk

    Article • Canadian Journal of Diabetes, June 2018, Elsevier

    Prof. J. David Spence

  94. Supplemental Vitamins and Minerals for CVD Prevention and Treatment

    Article • Journal of the American College of Cardiology, June 2018, Elsevier

    Prof. J. David Spence

  95. Metabolic products of the intestinal microbiome and extremes of atherosclerosis

    Article • Atherosclerosis, June 2018, Elsevier

    Prof. J. David Spence

  96. Diastolic J curve, cuff artefact and low targets for SBP

    Article • Journal of Hypertension, June 2018, Wolters Kluwer Health

    Prof. J. David Spence

  97. Problems with polypills

    Article • International Journal of Stroke, May 2018, SAGE Publications

    Prof. J. David Spence

  98. The Spectrum of Subclinical Primary Aldosteronism and Incident Hypertension

    Article • Annals of Internal Medicine, May 2018, American College of Physicians

    Prof. J. David Spence

  99. B Vitamins for Stroke Prevention

    Article • Journal of the American College of Cardiology, May 2018, Elsevier

    Prof. J. David Spence

  100. Accuracy of Cardiovascular Risk Prediction Varies by Neighborhood Socioeconomic Position

    Article • Annals of Internal Medicine, May 2018, American College of Physicians

    Prof. J. David Spence

  101. Cardioembolic stroke: everything has changed

    Article • Stroke and Vascular Neurology, March 2018, BMJ

    Prof. J. David Spence

  102. Controlling resistant hypertension

    Article • Stroke and Vascular Neurology, February 2018, BMJ

    Prof. J. David Spence

  103. How to identify which patients with asymptomatic carotid stenosis could benefit from endarterectomy or stenting

    Article • Stroke and Vascular Neurology, February 2018, BMJ

    Prof. J. David Spence

  104. Effect of wine on carotid atherosclerosis in type 2 diabetes: a 2-year randomized controlled trial

    Article • European Journal of Clinical Nutrition, January 2018, Springer Science + Business Media

    Prof. J. David Spence

  105. Diet for stroke prevention

    Article • Stroke and Vascular Neurology, January 2018, BMJ

    Prof. J. David Spence

  106. Letter by Spence Regarding Article, “Serum Potassium Is Positively Associated With Stroke and Mortality in the Large, Population-Based Malmö Preventive Project Cohort”

    Article • Stroke, January 2018, Wolters Kluwer Health

    Prof. J. David Spence

  107. Homocysteine Lowering with B Vitamins for Stroke Prevention—A History

    Article • touchREVIEWS in Neurology, January 2018, Touch Digital Media, Ltd.

    Prof. J. David Spence

  108. Hypertension in US-born vs. foreign-born African-Americans

    Article • Journal of Hypertension, December 2017, Wolters Kluwer Health

    Prof. J. David Spence

  109. Association of homocysteine and smoking with cerebral microemboli in patients with mechanical heart valves: a transcranial Doppler study

    Article • Stroke and Vascular Neurology, November 2017, BMJ

    Prof. J. David Spence

  110. Letter by Spence Regarding Article, “Antiplatelet Regimen for Patients With Breakthrough Strokes While on Aspirin: A Systematic Review and Meta-Analysis”

    Article • Stroke, October 2017, Wolters Kluwer Health

    Prof. J. David Spence

  111. Systolic blood pressure targets, diastolic J curve and cuff artefact in blood pressure measurement: a note of caution

    Article • September 2017, Wiley

    Prof. J. David Spence

  112. Patent Foramen Ovale Closure or Antiplatelet Therapy for Cryptogenic Stroke

    Article • New England Journal of Medicine, September 2017, New England Journal of Medicine (NEJM/MMS)

    Prof. J. David Spence, Director of the stroke unit, DMSci, clinical research associate professor Helle K. Iversen

  113. Smoking cessation and outcome after ischemic stroke or TIA

    Article • Neurology, September 2017, Wolters Kluwer Health

    Prof. J. David Spence, Prof. Dr. Otto W. Witte, Dr William D Strain

  114. B vitamins in stroke prevention: time to reconsider

    Article • The Lancet Neurology, September 2017, Elsevier

    Prof. J. David Spence

  115. Sensitive three-dimensional ultrasound assessment of carotid atherosclerosis by weighted average of local vessel wall and plaque thickness change

    Article • Medical Physics, August 2017, Wiley

    Prof. J. David Spence

  116. Motor recovery beginning 23 years after ischemic stroke

    Article • Journal of Neurophysiology, August 2017, American Physiological Society

    Prof. J. David Spence

  117. Cuff Artifact, J Curve, and Application of Hypertension Guidelines in the Elderly

    Article • Canadian Journal of Cardiology, August 2017, Elsevier

    Prof. J. David Spence

  118. Approaching Automated 3-Dimensional Measurement of Atherosclerotic Plaque Volume ∗

    Article • Journal of the American College of Cardiology, July 2017, Elsevier

    Prof. J. David Spence

  119. Recent advances in preventing stroke recurrence

    Article • F1000Research, June 2017, Faculty of 1000, Ltd.

    Prof. J. David Spence

  120. Blood pressure gradients in cerebral arteries: a clue to pathogenesis of cerebral small vessel disease

    Article • Stroke and Vascular Neurology, June 2017, BMJ

    Prof. J. David Spence

  121. Nutrition in Stroke Prevention

    Article • Seminars in Neurology, June 2017, Thieme Publishing Group

    Prof. J. David Spence

  122. Resistant Atherosclerosis

    Article • Stroke, May 2017, Wolters Kluwer Health

    Prof. J. David Spence

  123. Physiological Phenotyping for Personalized Therapy of Uncontrolled Hypertension in Africa

    Article • American Journal of Hypertension, May 2017, Oxford University Press (OUP)

    Prof. J. David Spence

  124. Rational Medical Therapy Is the Key to Effective Cardiovascular Disease Prevention

    Article • Canadian Journal of Cardiology, May 2017, Elsevier

    Prof. J. David Spence

  125. Asymptomatic carotid stenosis

    Article • Neurology, April 2017, Wolters Kluwer Health

    Prof. J. David Spence

  126. Cardiovascular Efficacy and Safety of Bococizumab in High-Risk Patients

    Article • New England Journal of Medicine, April 2017, New England Journal of Medicine (NEJM/MMS)

    Prof. J. David Spence, Dr DIEGO BELLIDO, Professor Dmitry Zateyshchikov

  127. [ 18 F]-NaF PET/CT Identifies Active Calcification in Carotid Plaque

    Article • JACC Cardiovascular Imaging, April 2017, Elsevier

    Prof. J. David Spence

  128. 3D Ultrasound for Imaging and Quantifying Carotid Ulcers

    Article • American Journal of Neuroradiology, March 2017, American Society of Neuroradiology (ASNR)

    Prof. J. David Spence

  129. Diastolic Hypotension and Myocardial Ischemia

    Article • Journal of the American College of Cardiology, March 2017, Elsevier

    Prof. J. David Spence

  130. Transcranial Doppler monitoring for microemboli: a marker of a high-risk carotid plaque

    Article • Seminars in Vascular Surgery, March 2017, Elsevier

    Prof. J. David Spence

  131. Carotid plaque burden is associated with higher levels of total homocysteine

    Article • Stroke and Vascular Neurology, February 2017, BMJ

    Prof. J. David Spence

  132. CADASIL accelerated by acute hypotension

    Article • Neurology, February 2017, Wolters Kluwer Health

    Prof. J. David Spence

  133. Hypertension in blacks

    Article • Journal of Hypertension, February 2017, Wolters Kluwer Health

    Prof. J. David Spence

  134. High Frequency of Variants of Candidate Genes in Black Africans with Low Renin-Resistant Hypertension

    Article • American Journal of Hypertension, January 2017, Oxford University Press (OUP)

    Prof. J. David Spence

  135. Effects of eplerenone on resistance to antihypertensive medication in patients with primary or secondary hyperaldosteronism

    Article • Journal of Translational Internal Medicine, January 2017, De Gruyter

    Prof. J. David Spence

  136. Increased Coagulation With Aging: Importance of Homocysteine and Vitamin B12

    Article • Circulation Journal, January 2017, Japanese Circulation Society

    Prof. J. David Spence

  137. Henry J.M. Barnett

    Article • Stroke, January 2017, Wolters Kluwer Health

    Prof. J. David Spence

  138. Determinants of carotid plaque burden

    Article • Atherosclerosis, December 2016, Elsevier

    Prof. J. David Spence

  139. Folic acid supplementation and chronic kidney disease progression

    Article • December 2016, Elsevier

    Prof. J. David Spence

  140. Re: ‘Transcranial Doppler Ultrasound Detection of Microemboli as a Predictor of Cerebral Events in Patients with Symptomatic and Asymptomatic Carotid Disease: A Systematic Review and Meta-Analysis’

    Article • European Journal of Vascular and Endovascular Surgery, November 2016, Elsevier

    Prof. J. David Spence

  141. Intestinal Microbiome and Atherosclerosis

    Article • EBioMedicine, November 2016, Elsevier

    Prof. J. David Spence

  142. Statins probably do not cause cataracts

    Article • Atherosclerosis, November 2016, Elsevier

    Prof. J. David Spence

  143. Folic Acid Therapy Reduces the First Stroke Risk Associated With Hypercholesterolemia Among Hypertensive Patients

    Article • Stroke, October 2016, Wolters Kluwer Health

    Prof. J. David Spence

  144. Editorial: Time for Earlier and More Intensive Preventive Therapy

    Article • Current Vascular Pharmacology, October 2016, Bentham Science Publishers

    Prof. J. David Spence

  145. Latest Skirmishes in the Long-Term Battle Between Carotid Endarterectomy and Stenting

    Article • Stroke, September 2016, Wolters Kluwer Health

    Prof. J. David Spence

  146. Cryptogenic Stroke

    Article • New England Journal of Medicine, September 2016, New England Journal of Medicine (NEJM/MMS)

    Prof. J. David Spence

  147. Taking care of volunteers in a stroke trial: a new assisted-management strategy

    Article • Stroke and Vascular Neurology, September 2016, BMJ

    Prof. J. David Spence

  148. Amiodarone, Lidocaine, or Placebo in Out-of-Hospital Cardiac Arrest

    Article • New England Journal of Medicine, August 2016, New England Journal of Medicine (NEJM/MMS)

    Prof. J. David Spence

  149. Transcranial Doppler is Complementary to Echocardiography for Detection and Risk Stratification of Patent Foramen Ovale

    Article • Canadian Journal of Cardiology, August 2016, Elsevier

    Prof. J. David Spence

  150. Homocysteine lowering for stroke prevention: Unravelling the complexity of the evidence

    Article • International Journal of Stroke, July 2016, SAGE Publications

    Prof. J. David Spence

  151. Recent advances in pathogenesis, assessment, and treatment of atherosclerosis

    Article • F1000Research, July 2016, Faculty of 1000, Ltd.

    Prof. J. David Spence

  152. Transcranial Doppler Emboli Identifies Asymptomatic Carotid Patients at High Stroke Risk: Why This Technique Should be Used More Widely

    Article • Angiology, July 2016, SAGE Publications

    Prof. J. David Spence

  153. Strategies for improving blood pressure control in Africa

    Article • May 2016, Springer Science + Business Media

    Prof. J. David Spence

  154. Appropriate management of asymptomatic carotid stenosis

    Article • Stroke and Vascular Neurology, April 2016, BMJ

    Prof. J. David Spence

  155. Endarterectomy vs. stenting vs. medical therapy

    Article • International Journal of Stroke, April 2016, SAGE Publications

    Prof. J. David Spence

  156. Pioglitazone after Ischemic Stroke or Transient Ischemic Attack

    Article • New England Journal of Medicine, April 2016, New England Journal of Medicine (NEJM/MMS)

    Prof. J. David Spence, Prof. Dr. Otto W. Witte, Dr William D Strain

  157. Endarterectomy, Stenting, or Neither for Asymptomatic Carotid-Artery Stenosis

    Article • New England Journal of Medicine, March 2016, New England Journal of Medicine (NEJM/MMS)

    Prof. J. David Spence

  158. Metabolic vitamin B12 deficiency: a missed opportunity to prevent dementia and stroke

    Article • Nutrition Research, February 2016, Elsevier

    Prof. J. David Spence

  159. Plaque Assessment in the Management of Patients with Asymptomatic Carotid Stenosis

    Article • Neuroimaging Clinics of North America, February 2016, Elsevier

    Prof. J. David Spence

  160. Three-Dimensional Ultrasound of Carotid Plaque

    Article • Neuroimaging Clinics of North America, February 2016, Elsevier

    Prof. J. David Spence

  161. Overcoming Challenges With Statin Therapy

    Article • Journal of the American Heart Association, January 2016, Wolters Kluwer Health

    Prof. J. David Spence

  162. Dietary cholesterol and egg yolk should be avoided by patients at risk of vascular disease

    Article • Journal of Translational Internal Medicine, January 2016, De Gruyter

    Prof. J. David Spence

  163. Adding carotid total plaque area to the Framingham risk score improves cardiovascular risk classification

    Article • Archives of Medical Science, January 2016, Termedia Sp. z.o.o.

    Prof. J. David Spence

  164. Hypertension and Stroke

    Article • January 2016, Springer Science + Business Media

    Prof. J. David Spence

  165. Definition of Best Medical Treatment in Asymptomatic and Symptomatic Carotid Artery Stenosis

    Article • Angiology, December 2015, SAGE Publications

    Prof. J. David Spence

  166. Management of Patients with an Asymptomatic Carotid Stenosis—Medical Management, Endovascular Treatment, or Carotid Endarterectomy?

    Article • Current Neurology and Neuroscience Reports, December 2015, Springer Science + Business Media

    Prof. J. David Spence

  167. Transcranial Doppler: Uses in Stroke Prevention

    Article • Journal for Vascular Ultrasound, December 2015, SAGE Publications

    Prof. J. David Spence

  168. Effect of renal impairment on atherosclerosis: only partially mediated by homocysteine

    Article • Nephrology Dialysis Transplantation, November 2015, Oxford University Press (OUP)

    Prof. J. David Spence

  169. J Curve and Cuff Artefact, and Diagnostic Inertia in Resistant Hypertension

    Article • Hypertension, November 2015, Wolters Kluwer Health

    Prof. J. David Spence

  170. Risk of Stroke at the Time of Carotid Occlusion

    Article • JAMA Neurology, November 2015, American Medical Association (AMA)

    Prof. J. David Spence

  171. Review and prioritization of stroke research recommendations to address the mission of the World Stroke Organization: a call to action from the WSO Research Committee

    Article • International Journal of Stroke, October 2015, SAGE Publications

    Prof. J. David Spence

  172. Carotid Ultrasound Phenotypes Are Biologically Distinct

    Article • Arteriosclerosis Thrombosis and Vascular Biology, August 2015, Wolters Kluwer Health

    Prof. J. David Spence

  173. Letter by Spence Regarding Article, “Diet and Stroke: Recent Evidence Supporting a Mediterranean-Style Diet and Food in the Primary Prevention of Stroke”

    Article • Stroke, August 2015, Wolters Kluwer Health

    Prof. J. David Spence

  174. Importance of sex and gender in atherosclerosis and cardiovascular disease

    Article • Atherosclerosis, July 2015, Elsevier

    Prof. J. David Spence

  175. 3D carotid reconstructions: imaging, pathology, algorithms and pipelines

    Article • Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques, May 2015, Cambridge University Press

    Prof. J. David Spence

  176. Blood Pressure Control in Canada: The View From a Stroke Prevention Clinic

    Article • Canadian Journal of Cardiology, May 2015, Elsevier

    Prof. J. David Spence

  177. Dilemmas in Diagnosing and Managing Hypertension: Is White Coat Hypertension Benign?

    Article • Canadian Journal of Cardiology, May 2015, Elsevier

    Prof. J. David Spence

  178. Management of Asymptomatic Carotid Stenosis

    Article • Neurologic Clinics, May 2015, Elsevier

    Prof. J. David Spence

  179. Statins and Cataracts: Reverse Causality?

    Article • Canadian Journal of Cardiology, May 2015, Elsevier

    Prof. J. David Spence

  180. Recent advances in atrial fibrillation and stroke

    Article • Neurological Research, April 2015, Taylor & Francis

    Prof. J. David Spence

  181. Aspirin for Prevention of Cardiovascular Events in Older Japanese Patients

    Article • April 2015, American Medical Association (AMA)

    Prof. J. David Spence

  182. Letter by Spence Regarding Article, "Differential Effect of B-Vitamin Therapy by Antiplatelet Use on Risk of Recurrent Vascular Events After Stroke"

    Article • Stroke, April 2015, Wolters Kluwer Health

    Prof. J. David Spence

  183. Measurement of Carotid Plaque Burden

    Article • JAMA Neurology, April 2015, American Medical Association (AMA)

    Prof. J. David Spence

  184. Management of resistant hypertension

    Article • Canadian Medical Association Journal, March 2015, Canadian Medical Association (CMA)

    Prof. J. David Spence

  185. Atrial Premature Beats Predict Atrial Fibrillation in Cryptogenic Stroke: Results From the EMBRACE Trial

    Article • Stroke, February 2015, Wolters Kluwer Health

    Prof. J. David Spence

  186. Are some diets "mass murder"? Mediterranean diet is not to blame for increased carbohydrate intake

    Article • BMJ, February 2015, BMJ

    Prof. J. David Spence

  187. Statins and Intracerebral Hemorrhage

    Article • JAMA Neurology, February 2015, American Medical Association (AMA)

    Prof. J. David Spence

  188. The 99mTc-DTPA Urinary Clearance Method May Be Preferable to the Plasma Disappearance Method for Assessing Glomerular Filtration Rate in Diabetic Nephropathy

    Article • Nephron Clinical Practice, January 2015, Karger Publishers

    Prof. J. David Spence, Professor Guido Filler

  189. Pioglitazone for secondary prevention after ischemic stroke and transient ischemic attack: Rationale and design of the Insulin Resistance Intervention after Stroke Trial

    Article • American Heart Journal, December 2014, Elsevier

    Prof. J. David Spence

  190. Risk of Vascular Disease in Premenopausal Women With Diabetes Mellitus

    Article • Clinical Therapeutics, December 2014, Elsevier

    Prof. J. David Spence

  191. Identifying Which Patients With Asymptomatic Carotid Stenosis Could Benefit From Intervention: Table.

    Article • Stroke, October 2014, Wolters Kluwer Health

    Prof. J. David Spence

  192. Recurrent Stroke and Patent Foramen Ovale

    Article • Stroke, October 2014, Wolters Kluwer Health

    Prof. J. David Spence

  193. Cryptogenic Stroke and Atrial Fibrillation

    Article • New England Journal of Medicine, September 2014, New England Journal of Medicine (NEJM/MMS)

    Prof. J. David Spence

  194. Secular Trends in Ischemic Stroke Subtypes and Stroke Risk Factors

    Article • Stroke, September 2014, Wolters Kluwer Health

    Prof. J. David Spence

  195. Statins and Ischemic Stroke

    Article • JAMA, August 2014, American Medical Association (AMA)

    Prof. J. David Spence

  196. How far to lower blood pressure in the long term, after a stroke?

    Article • Journal of Hypertension, August 2014, Wolters Kluwer Health

    Prof. J. David Spence

  197. Time course of atherosclerosis regression

    Article • Atherosclerosis, August 2014, Elsevier

    Prof. J. David Spence

  198. Carnitine therapy for the treatment of metabolic syndrome and cardiovascular disease: Evidence and controversies

    Article • Nutrition Metabolism and Cardiovascular Diseases, August 2014, Elsevier

    Prof. J. David Spence

  199. Three-Dimensional Carotid Ultrasound Plaque Texture Predicts Vascular Events

    Article • Stroke, July 2014, Wolters Kluwer Health

    Prof. J. David Spence

  200. Arterial age as a substitute for chronological age in the AGLA risk function could improve coronary risk prediction

    Article • Swiss Medical Weekly, July 2014, EMH Swiss Medical Publishers, Ltd.

    Prof. J. David Spence

  201. Atrial Fibrillation in Patients with Cryptogenic Stroke

    Article • New England Journal of Medicine, June 2014, New England Journal of Medicine (NEJM/MMS)

    Prof. J. David Spence

  202. Effects of homocysteine lowering with B vitamins on cognitive aging: meta-analysis of 11 trials with cognitive data on 22,000 individuals

    Article • American Journal of Clinical Nutrition, June 2014, Oxford University Press (OUP)

    Prof. J. David Spence

  203. Pulmonary Abnormalities and Carotid Atherosclerosis in Ex-Smokers without Airflow Limitation

    Article • COPD Journal of Chronic Obstructive Pulmonary Disease, June 2014, Taylor & Francis

    Prof. J. David Spence

  204. A Single Fixed-Dose Combination for All Patients Is Bad Medicine

    Article • Canadian Journal of Cardiology, May 2014, Elsevier

    Prof. J. David Spence

  205. Volume of Carotid Artery Ulceration as a Predictor of Cardiovascular Events

    Article • Stroke, April 2014, Wolters Kluwer Health

    Prof. J. David Spence

  206. Microhabitat Use in a Northern Peripheral Population ofApodemia mormo: Factors Beyond the Host Plant

    Article • Journal of the Lepidopterists’ Society, March 2014, Lepidopterists' Society

    Prof. J. David Spence

  207. Free fatty acids to predict recurrent ischemic stroke

    Article • Neurology, February 2014, Wolters Kluwer Health

    Prof. J. David Spence

  208. Effects of the Intestinal Microbiome on Constituents of Red Meat and Egg Yolks: A New Window Opens on Nutrition and Cardiovascular Disease

    Article • Canadian Journal of Cardiology, February 2014, Elsevier

    Prof. J. David Spence

  209. SPARKLE (Subtypes of Ischaemic Stroke Classification System), Incorporating Measurement of Carotid Plaque Burden: A New Validated Tool for the Classification of Ischemic Stroke Subtypes

    Article • Neuroepidemiology, January 2014, Karger Publishers

    Prof. J. David Spence

  210. Carotid Stenosis

    Article • New England Journal of Medicine, December 2013, New England Journal of Medicine (NEJM/MMS)

    Prof. J. David Spence

  211. Egg consumption and coronary disease: Letter to the editor regarding Chagas P, Caramori P, Galdino TP, Barcellos CS, Gomes I, Schwanke CH. Egg consumption and coronary atherosclerotic burden. Atherosclerosis 2013 August;229(2):381–4

    Article • Atherosclerosis, December 2013, Elsevier

    Prof. J. David Spence

  212. Trust between specialists and family physicians

    Article • Canadian Medical Association Journal, November 2013, Canadian Medical Association (CMA)

    Prof. J. David Spence

  213. One, two and three-dimensional ultrasound measurements of carotid atherosclerosis before and after cardiac rehabilitation: preliminary results of a randomized controlled trial

    Article • Cardiovascular Ultrasound, November 2013, Springer Science + Business Media

    Prof. J. David Spence

  214. Intensive risk factor control in stroke prevention

    Article • F1000Prime Reports, October 2013, Faculty of 1000, Ltd.

    Prof. J. David Spence

  215. Retinal Vasculature: A Window on the Brain

    Article • Hypertension, August 2013, Wolters Kluwer Health

    Prof. J. David Spence

  216. Barometer in the Storm—Carotid Artery Plaque Quantified by Three-Dimensional Ultrasound

    Article • Journal of the American Society of Echocardiography, August 2013, Elsevier

    Prof. J. David Spence

  217. Treatment of Renal Artery Stenosis

    Article • June 2013, American Medical Association (AMA)

    Prof. J. David Spence

  218. Progression of Carotid Plaque Volume Predicts Cardiovascular Events

    Article • Stroke, June 2013, Wolters Kluwer Health

    Prof. J. David Spence

  219. Closure of Patent Foramen Ovale versus Medical Therapy after Cryptogenic Stroke

    Article • New England Journal of Medicine, March 2013, New England Journal of Medicine (NEJM/MMS)

    Prof. J. David Spence

  220. Why Calls for More Routine Carotid Stenting Are Currently Inappropriate: An International, Multispecialty, Expert Review and Position Statement

    Article • Stroke, March 2013, Wolters Kluwer Health

    Prof. J. David Spence

  221. Egg yolk consumption, smoking and carotid plaque: Reply to letters to the Editor by Sean Lucan and T Dylan Olver et al.

    Article • Atherosclerosis, March 2013, Elsevier

    Prof. J. David Spence

  222. Atherosclerosis Imaging and the Canadian Atherosclerosis Imaging Network

    Article • Canadian Journal of Cardiology, March 2013, Elsevier

    Prof. J. David Spence

  223. Effects of folic acid supplementation on overall and site-specific cancer incidence during the randomised trials: meta-analyses of data on 50 000 individuals

    Article • March 2013, Elsevier

    Prof. J. David Spence

  224. Migraine, Shear Stress, and Platelet Serotonin

    Article • March 2013, Wiley

    Prof. J. David Spence

  225. Diabetes, Intracranial Stenosis and Microemboli in Asymptomatic Carotid Stenosis

    Article • Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques, March 2013, Cambridge University Press

    Prof. J. David Spence

  226. Asymptomatic Carotid Stenosis

    Article • Circulation, February 2013, Wolters Kluwer Health

    Prof. J. David Spence

  227. Blood pressure and opera

    Article • Journal of Hypertension, February 2013, Wolters Kluwer Health

    Prof. J. David Spence

  228. Ultrasonographic Measure of Carotid Plaque Burden

    Article • JACC Cardiovascular Imaging, January 2013, Elsevier

    Dr Tatjana Rundek, Prof. J. David Spence

  229. B vitamin therapy for homocysteine: renal function and vitamin B12 determine cardiovascular outcomes

    Article • Clinical Chemistry and Laboratory Medicine (CCLM), January 2013, De Gruyter

    Prof. J. David Spence

  230. Antihypertensive treatment can prevent stroke and cognitive decline

    Article • Nature Reviews Neurology, December 2012, Springer Science + Business Media

    Prof. J. David Spence

  231. Atrial fibrillation and stroke prevention: is warfarin still an option? Yes

    Article • Journal of Neural Transmission, December 2012, Springer Science + Business Media

    Prof. J. David Spence

  232. Effects of Aldosterone on Human Atherosclerosis: Plasma Aldosterone and Progression of Carotid Plaque

    Article • Canadian Journal of Cardiology, November 2012, Elsevier

    Prof. J. David Spence

  233. Imaging atherosclerosis with hybrid [18F]fluorodeoxyglucose positron emission tomography/computed tomography imaging: What Leonardo da Vinci could not see

    Article • Journal of Nuclear Cardiology, October 2012, Springer Science + Business Media

    Prof. J. David Spence

  234. Egg yolk consumption and carotid plaque

    Article • Atherosclerosis, October 2012, Elsevier

    Prof. J. David Spence

  235. Premature Atherosclerosis Is Associated With Hypovitaminosis D and Angiotensin-Converting Enzyme Inhibitor Non-use in Lupus Patients

    Article • The American Journal of the Medical Sciences, October 2012, Elsevier

    Prof. J. David Spence

  236. Letter to the Editor: The ezetimibe ‘controversy' is a misunderstanding

    Article • Expert Opinion on Pharmacotherapy, September 2012, Informa Healthcare

    Prof. J. David Spence

  237. Albuminuria and risk of stroke in African Americans: A marker of uncontrolled hypertension?

    Article • Neurology, September 2012, Wolters Kluwer Health

    Prof. J. David Spence

  238. Statins do not cause intracerebral hemorrhage

    Article • Neurology, July 2012, Wolters Kluwer Health

    Prof. J. David Spence

  239. Genetics of atherosclerosis: The power of plaque burden and progression

    Article • Atherosclerosis, July 2012, Elsevier

    Prof. J. David Spence

  240. Mechanisms of Lipoprotein(a) Pathogenicity: Prothrombotic, Proatherosclerotic, or Both?

    Article • Arteriosclerosis Thrombosis and Vascular Biology, July 2012, Wolters Kluwer Health

    Prof. J. David Spence

  241. Antiplatelet therapy and the effects of B vitamins in patients with previous stroke or transient ischaemic attack: a post-hoc subanalysis of VITATOPS, a randomised, placebo-controlled trial

    Article • The Lancet Neurology, June 2012, Elsevier

    Professor Malcolm R Macleod, Prof. J. David Spence

  242. Lessons From Africa: The Importance of Measuring Plasma Renin and Aldosterone in Resistant Hypertension

    Article • Canadian Journal of Cardiology, May 2012, Elsevier

    Prof. J. David Spence

  243. Why the US Center for Medicare and Medicaid Services Should Not Extend Reimbursement Indications for Carotid Artery Angioplasty/Stenting

    Article • Angiology, April 2012, SAGE Publications

    Prof. J. David Spence

  244. Pseudohypertension

    Article • Hypertension, April 2012, Wolters Kluwer Health

    Prof. J. David Spence

  245. Why the United States Center for Medicare and Medicaid Services (CMS) should not extend reimbursement indications for carotid artery angioplasty/stenting

    Article • Brain and Behavior, March 2012, Wiley

    Prof. J. David Spence

  246. Why the United States Center for Medicare and Medicaid Services (CMS) Should not Extend Reimbursement Indications for Carotid Artery Angioplasty/Stenting

    Article • European Journal of Vascular and Endovascular Surgery, March 2012, Elsevier

    Prof. J. David Spence

  247. Identifying high-risk asymptomatic carotid stenosis

    Article • Expert Opinion on Medical Diagnostics, February 2012, Informa Healthcare

    Prof. J. David Spence

  248. Why the United States Center for Medicare and Medicaid Services should not extend reimbursement indications for carotid artery angioplasty/stenting

    Article • Vascular, January 2012, SAGE Publications

    Prof. J. David Spence

  249. Ezetimibe and Regression of Carotid Atherosclerosis

    Article • Stroke, January 2012, Wolters Kluwer Health

    Prof. J. David Spence

  250. Carotid plaque measurement is superior to IMT

    Article • Atherosclerosis, January 2012, Elsevier

    Prof. J. David Spence

  251. Understanding the Complexity of Homocysteine Lowering With Vitamins

    Article • December 2011, American Medical Association (AMA)

    Prof. J. David Spence

  252. High-risk asymptomatic carotid stenosis: Ulceration on 3D ultrasound vs TCD microemboli

    Article • Neurology, August 2011, Wolters Kluwer Health

    Prof. J. David Spence

  253. Short-acting nifedipine and risk of stroke

    Article • Neurology, August 2011, Wolters Kluwer Health

    Prof. J. David Spence

  254. New and Emerging Weight Management Strategies for Busy Ambulatory Settings: A Scientific Statement From the American Heart Association * Endorsed by the Society of Behavioral Medicine

    Article • Circulation, August 2011, Wolters Kluwer Health

    Prof. J. David Spence

  255. Asymptomatic Carotid Stenosis: Identifying Patients at High Enough Risk to Warrant Endarterectomy or Stenting

    Article • Stroke, July 2011, Wolters Kluwer Health

    Prof. J. David Spence

  256. Influence of Noninvasive Cardiovascular Imaging in Primary Prevention

    Article • Archives of Internal Medicine, June 2011, American Medical Association (AMA)

    Professor Luigi P. Badano, Prof. J. David Spence

  257. Reply to Letters from Dr Maria Luz Fernandez, Eddie Vos, and Dr Niva Shapira

    Article • Canadian Journal of Cardiology, March 2011, Elsevier

    Prof. J. David Spence

  258. Toward Clinical Applications of Carotid Ultrasound: Intima-Media Thickness, Plaque Area, and Three-Dimensional Phenotypes

    Article • January 2011, Springer Science + Business Media

    Dr Tatjana Rundek, Prof. J. David Spence

  259. Carotid Plaque Surface Irregularity

    Article • January 2011, Springer Science + Business Media

    Prof. J. David Spence

  260. Volumetric Evaluation of Carotid Atherosclerosis Using 3-Dimensional Ultrasonic Imaging

    Article • January 2011, Springer Science + Business Media

    Prof. J. David Spence

  261. Response to Letter by Hadjiev et al

    Article • Stroke, December 2010, Wolters Kluwer Health

    Prof. J. David Spence

  262. 3D Carotid Ultrasound Imaging

    Article • November 2010, Springer Science + Business Media

    Prof. J. David Spence

  263. Clinical Clues to Paradoxical Embolism

    Article • International Journal of Stroke, November 2010, SAGE Publications

    Prof. J. David Spence

  264. Effects of Lowering Homocysteine Levels With B Vitamins on Cardiovascular Disease, Cancer, and Cause-Specific MortalityMeta-analysis of 8 Randomized Trials Involving 37 485 IndividualsEffects of Lowering Homocysteine Lev...

    Article • Archives of Internal Medicine, October 2010, American Medical Association (AMA)

    Prof. J. David Spence

  265. Is there a role for revascularisation in asymptomatic carotid stenosis? No

    Article • BMJ, September 2010, BMJ

    Prof. J. David Spence

  266. Is there a role for revascularisation in asymptomatic carotid stenosis? Yes

    Article • BMJ, September 2010, BMJ

    Prof. J. David Spence

  267. B vitamins in patients with recent transient ischaemic attack or stroke in the VITAmins TO Prevent Stroke (VITATOPS) trial: a randomised, double-blind, parallel, placebo-controlled trial

    Article • The Lancet Neurology, September 2010, Elsevier

    Professor Malcolm R Macleod, Prof. J. David Spence

  268. B-Vitamin Therapy for Diabetic Nephropathy—Reply

    Article • August 2010, American Medical Association (AMA)

    Prof. J. David Spence

  269. Secondary stroke prevention

    Article • Nature Reviews Neurology, August 2010, Springer Science + Business Media

    Prof. J. David Spence

  270. Identifying high-risk patients from carotid plaque composition

    Article • Nature Reviews Cardiology, August 2010, Springer Science + Business Media

    Prof. J. David Spence

  271. Asymptomatic Carotid Stenosis: Mainly a Medical Condition

    Article • Vascular, June 2010, Royal Society Publishing

    Prof. J. David Spence

  272. Physiologic Tailoring of Treatment in Resistant Hypertension

    Article • Current Cardiology Reviews, May 2010, Bentham Science Publishers

    Prof. J. David Spence

  273. Effect of B-Vitamin Therapy on Progression of Diabetic Nephropathy

    Article • April 2010, American Medical Association (AMA)

    Prof. J. David Spence

  274. Treating Arteries Instead of Risk Factors: A Paradigm Change in Management of Atherosclerosis

    Article • Stroke, April 2010, Wolters Kluwer Health

    Prof. J. David Spence

  275. Extremes of Unexplained Variation as a Phenotype: An Efficient Approach for Genome-Wide Association Studies of Cardiovascular Disease

    Article • Circulation Cardiovascular Genetics, April 2010, Wolters Kluwer Health

    Prof. J. David Spence

  276. Three-dimensional ultrasound-based texture analysis of the effect of atorvastatin on carotid atherosclerosis

    Article • March 2010, SPIE

    Prof. J. David Spence

  277. Dietary Intervention to Reverse Carotid Atherosclerosis

    Article • Circulation, March 2010, Wolters Kluwer Health

    Prof. J. David Spence

  278. The role of lipoprotein(a) in the formation of arterial plaques, stenoses and occlusions

    Article • Canadian Journal of Cardiology, March 2010, Elsevier

    Prof. J. David Spence

  279. Improvement of cardiovascular risk prediction: time to review current knowledge, debates, and fundamentals on how to assess test characteristics

    Article • European Journal of Cardiovascular Prevention & Rehabilitation, February 2010, SAGE Publications

    Prof. J. David Spence

  280. Effects of Intensive Medical Therapy on Microemboli and Cardiovascular Risk in Asymptomatic Carotid Stenosis

    Article • Archives of Neurology, February 2010, American Medical Association (AMA)

    Prof. J. David Spence

  281. Three-Dimensional Carotid Ultrasound Segmentation Variability Dependence on Signal Difference and Boundary Orientation

    Article • Ultrasound in Medicine & Biology, January 2010, Elsevier

    Prof. J. David Spence

  282. Three-dimensional Ultrasound Quantification of Intensive Statin Treatment of Carotid Atherosclerosis

    Article • Ultrasound in Medicine & Biology, November 2009, Elsevier

    Prof. J. David Spence

  283. Treating Hypertension in Acute Ischemic Stroke

    Article • Hypertension, August 2009, Wolters Kluwer Health

    Prof. J. David Spence

  284. Atrial fibrillation, stroke prevention therapy and aging

    Article • Nature Reviews Cardiology, July 2009, Springer Science + Business Media

    Prof. J. David Spence

  285. Longitudinal Ultrasound Evaluation of Carotid Atherosclerosis in One, Two and Three Dimensions

    Article • Ultrasound in Medicine & Biology, March 2009, Elsevier

    Prof. J. David Spence

  286. Mechanisms of thrombogenesis in atrial fibrillation

    Article • March 2009, Elsevier

    Prof. J. David Spence

  287. Analysis of carotid lumen surface morphology using three-dimensional ultrasound imaging

    Article • Physics in Medicine and Biology, January 2009, Institute of Physics Publishing

    Prof. J. David Spence

  288. Nonrigid registration of three-dimensional ultrasound and magnetic resonance images of the carotid arteries

    Article • Medical Physics, January 2009, Wiley

    Prof. J. David Spence

  289. Carotid Atherosclerosis and a Reduced Likelihood for Lowered Cognitive Performance in a Canadian First Nations Population

    Article • Neuroepidemiology, January 2009, Karger Publishers

    Prof. J. David Spence

  290. Diagnosis of primary aldosteronism: for medical management, not just surgery

    Article • Journal of Hypertension, January 2009, Wolters Kluwer Health

    Prof. J. David Spence

  291. Mesna for the Treatment of Hyperhomocysteinemia in Hemodialysis Patients

    Article • Blood Purification, January 2009, Karger Publishers

    Prof. J. David Spence

  292. Area-preserving flattening maps of 3D ultrasound carotid arteries images

    Article • Medical Image Analysis, December 2008, Elsevier

    Prof. J. David Spence

  293. Cryptogenic stroke and patent foramen ovale: Clinical clues to paradoxical embolism

    Article • Journal of the Neurological Sciences, December 2008, Elsevier

    Prof. J. David Spence

  294. Scan–rescan and intra-observer variability of magnetic resonance imaging of carotid atherosclerosis at 1.5 T and 3.0 T

    Article • Physics in Medicine and Biology, November 2008, Institute of Physics Publishing

    Prof. J. David Spence

  295. Is Carotid Intima-Media Thickness a Reliable Clinical Predictor?

    Article • November 2008, Elsevier

    Prof. J. David Spence

  296. A “Twisting and Bending” Model-Based Nonrigid Image Registration Technique for 3-D Ultrasound Carotid Images

    Article • IEEE Transactions on Medical Imaging, October 2008, Institute of Electrical & Electronics Engineers (IEEE)

    Prof. J. David Spence

  297. Angiotensin inhibition in renovascular disease: A population-based cohort study

    Article • American Heart Journal, September 2008, Elsevier

    Prof. J. David Spence

  298. The importance of distinguishing between diffuse carotid intima-media thickening and focal plaque

    Article • Canadian Journal of Cardiology, August 2008, Elsevier

    Prof. J. David Spence

  299. Quantification of carotid vessel wall and plaque thickness change using 3D ultrasound images

    Article • Medical Physics, July 2008, Wiley

    Prof. J. David Spence

  300. Lipoprotein(a) Is Associated Differentially With Carotid Stenosis, Occlusion, and Total Plaque Area

    Article • Arteriosclerosis Thrombosis and Vascular Biology, July 2008, Wolters Kluwer Health

    Prof. J. David Spence

  301. Geometry of the Carotid Bifurcation Predicts Its Exposure to Disturbed Flow

    Article • Stroke, June 2008, Wolters Kluwer Health

    Prof. J. David Spence

  302. Intra-Arterial Thrombolysis of Occluded Middle Cerebral Artery by Use of Collateral Pathways in Patients with Tandem Cervical Carotid Artery/Middle Cerebral Artery Occlusion

    Article • American Journal of Neuroradiology, June 2008, American Society of Neuroradiology (ASNR)

    Prof. J. David Spence

  303. Cerebrovascular events on awakening, patent foramen ovale and obstructive sleep apnea syndrome

    Article • Journal of the Neurological Sciences, May 2008, Elsevier

    Prof. J. David Spence

  304. Polypill: For Pollyanna*

    Article • International Journal of Stroke, May 2008, SAGE Publications

    Prof. J. David Spence

  305. Mesna for Treatment of Hyperhomocysteinemia in Hemodialysis Patients: A Placebo-Controlled, Double-Blind, Randomized Trial

    Article • Clinical Journal of the American Society of Nephrology, April 2008, American Society of Nephrology

    Prof. J. David Spence

  306. White-Coat Hypertension Is Hypertension

    Article • Hypertension, March 2008, Wolters Kluwer Health

    Prof. J. David Spence

  307. Nonrigid registration of carotid ultrasound and MR images using a "twisting and bending" model

    Article • March 2008, SPIE

    Prof. J. David Spence

  308. APPENDIX A: Carotid Endarterectomy-An Evidence-Based Review

    Article • CONTINUUM Lifelong Learning in Neurology, February 2008, Wolters Kluwer Health

    Prof. J. David Spence

  309. Mapping Spatial and Temporal Changes in Carotid Atherosclerosis from Three-Dimensional Ultrasound Images

    Article • Ultrasound in Medicine & Biology, January 2008, Elsevier

    Prof. J. David Spence

  310. Role of Renin-Angiotensin System Blockade in Atherosclerotic Renal Artery Stenosis and Renovascular Hypertension

    Article • Hypertension, October 2007, Wolters Kluwer Health

    Prof. J. David Spence

  311. Homocysteine-lowering therapy: a role in stroke prevention?

    Article • The Lancet Neurology, September 2007, Elsevier

    Prof. J. David Spence

  312. Letter by Rundek et al Regarding Article, "Prediction of Clinical Cardiovascular Events With Carotid Intima-Media Thickness: A Systematic Review and Meta-Analysis"

    Article • Circulation, August 2007, Wolters Kluwer Health

    Dr Tatjana Rundek, Prof. J. David Spence

  313. Mesna as a Nonvitamin Intervention to Lower Plasma Total Homocysteine Concentration: Implications for Assessment of the Homocysteine Theory of Atherosclerosis

    Article • The Journal of Clinical Pharmacology, August 2007, Wiley

    Prof. J. David Spence

  314. Stroke prevention in the high-risk patient

    Article • Expert Opinion on Pharmacotherapy, August 2007, Informa Healthcare

    Prof. J. David Spence

  315. Plasma total homocysteine in acute stroke

    Article • European Journal of Neurology, July 2007, Wiley

    Prof. J. David Spence

  316. SU-EE-A4-01: Development of Cardiac-Gated 3-Dimensional Ultrasound Imaging of Carotid Atherosclerosis

    Article • Medical Physics, June 2007, Wiley

    Prof. J. David Spence

  317. Validation of 3D Ultrasound Vessel Wall Volume: An Imaging Phenotype of Carotid Atherosclerosis

    Article • Ultrasound in Medicine & Biology, June 2007, Elsevier

    Prof. J. David Spence

  318. New treatment options for hypertension during acute ischemic or hemorrhagic stroke

    Article • Current Treatment Options in Cardiovascular Medicine, May 2007, Springer Science + Business Media

    Prof. J. David Spence

  319. Combining Multiple Approaches for the Secondary Prevention of Vascular Events After Stroke: A Quantitative Modeling Study

    Article • Stroke, April 2007, Wolters Kluwer Health

    Prof. J. David Spence

  320. Manual planimetric measurement of carotid plaque volume using three-dimensional ultrasound imaging

    Article • Medical Physics, March 2007, Wiley

    Prof. J. David Spence

  321. Effects of non-steroidal anti-inflammatory drugs on blood pressure

    Article • Journal of Hypertension, January 2007, Wolters Kluwer Health

    Prof. J. David Spence

  322. Hypertension Due to Central Nervous System Dysfunction

    Article • January 2007, Elsevier

    Prof. J. David Spence

  323. Intensive management of risk factors for accelerated atherosclerosis: the role of multiple interventions

    Article • Current Neurology and Neuroscience Reports, January 2007, Springer Science + Business Media

    Prof. J. David Spence

  324. Perspective on the efficacy analysis of the Vitamin Intervention for Stroke Prevention trial

    Article • Clinical Chemistry and Laboratory Medicine (CCLM), January 2007, De Gruyter

    Prof. J. David Spence

  325. The Effect of Mesna on Plasma Total Homocysteine Concentration in Hemodialysis Patients

    Article • January 2007, Elsevier

    Prof. J. David Spence

  326. 3D ultrasound analysis of carotid plaque volume and surface morphology

    Article • Ultrasonics, December 2006, Elsevier

    Prof. J. David Spence

  327. Carotid ultrasound phenotypes in vulnerable populations

    Article • Cardiovascular Ultrasound, November 2006, Springer Science + Business Media

    Prof. J. David Spence

  328. Homocysteine and Stroke Prevention: Have the Trials Settled the Issue?

    Article • International Journal of Stroke, November 2006, SAGE Publications

    Prof. J. David Spence

  329. Measurement of Intima-Media Thickness vs. Carotid Plaque: Uses in Patient Care, Genetic Research and Evaluation of New Therapies

    Article • International Journal of Stroke, November 2006, SAGE Publications

    Prof. J. David Spence

  330. Technology Insight: ultrasound measurement of carotid plaque—patient management, genetic research and therapy evaluation

    Article • Nature Clinical Practice Cardiovascular Medicine, November 2006, Springer Science + Business Media

    Prof. J. David Spence

  331. A Non-Rigid Image Registration Technique for 3D Ultrasound Carotid Images using a "Twisting and Bending" Model

    Article • August 2006, Institute of Electrical & Electronics Engineers (IEEE)

    Prof. J. David Spence

  332. Measuring Effects of Antiatherosclerotic Therapies

    Article • Journal of the American College of Cardiology, August 2006, Elsevier

    Prof. J. David Spence

  333. Quantification of progression and regression of carotid vessel atherosclerosis using 3D ultrasound images

    Article • August 2006, Institute of Electrical & Electronics Engineers (IEEE)

    Prof. J. David Spence

  334. Thiol exchange: An in vitro assay that predicts the efficacy of novel homocysteine lowering therapies

    Article • August 2006, Elsevier

    Prof. J. David Spence

  335. Nutrition and Stroke Prevention

    Article • Stroke, July 2006, Wolters Kluwer Health

    Prof. J. David Spence

  336. Relationship of the metabolic syndrome to carotid ultrasound traits

    Article • Cardiovascular Ultrasound, July 2006, Springer Science + Business Media

    Prof. J. David Spence

  337. Po-Thur Eve General-20: A Novel Non-Invasive 3D Ultrasound Imaging Phenotype of Carotid Atherosclerosis

    Article • Medical Physics, July 2006, Wiley

    Prof. J. David Spence

  338. Po-Thur Eve General-24: Non-Invasive Imaging Phenotypes of Carotid Atherosclerosis in Subjects: MRI, B-mode and 3D Ultrasound Measurements

    Article • Medical Physics, July 2006, Wiley

    Prof. J. David Spence

  339. Treating Hypertension in Acute Stroke: A Better Arrow for the Quiver

    Article • Hypertension, May 2006, Wolters Kluwer Health

    Prof. J. David Spence

  340. Lipoprotein(a): Involved in Events, but Not Burden of Atherosclerotic Disease?

    Article • Stroke, May 2006, Wolters Kluwer Health

    Prof. J. David Spence

  341. Folate supplementation and cardiovascular disease

    Article • April 2006, Elsevier

    Prof. J. David Spence

  342. Quantification of carotid vessel atherosclerosis

    Article • March 2006, SPIE

    Prof. J. David Spence

  343. Letter to the Editor: Individualized Therapy for Hypertension

    Article • Hypertension, January 2006, Wolters Kluwer Health

    Prof. J. David Spence

  344. Homocysteine: Call Off the Funeral

    Article • Stroke, January 2006, Wolters Kluwer Health

    Prof. J. David Spence

  345. 3D Ultrasound System for Analysis of Carotid Plaque Progression and Regression

    Article • January 2006, Institute of Electrical & Electronics Engineers (IEEE)

    Prof. J. David Spence

  346. Tutorial in Biostatistics: Analyzing Associations between Total Plasma Homocysteine and B Vitamins Using Optimal Categorization and Segmented Regression

    Article • Neuroepidemiology, January 2006, Karger Publishers

    Prof. J. David Spence

  347. Disparate Associations of a Functional Promoter Polymorphism in PCK1 With Carotid Wall Ultrasound Traits

    Article • Stroke, November 2005, Wolters Kluwer Health

    Prof. J. David Spence

  348. Vitamin Intervention for Stroke Prevention Trial: An Efficacy Analysis

    Article • Stroke, October 2005, Wolters Kluwer Health

    Prof. J. David Spence

  349. Absence of Microemboli on Transcranial Doppler Identifies Low-Risk Patients With Asymptomatic Carotid Stenosis

    Article • Stroke, October 2005, Wolters Kluwer Health

    Prof. J. David Spence

  350. Variation in the Carotid Bifurcation Geometry of Young Versus Older Adults: Implications for Geometric Risk of Atherosclerosis

    Article • Stroke, October 2005, Wolters Kluwer Health

    Prof. J. David Spence

  351. Erratum to “Differences between carotid wall morphological phenotypes measured by ultrasound in one, two and three dimensions” [Atherosclerosis 178(2) (2005) 319–325]

    Article • Atherosclerosis, October 2005, Elsevier

    Prof. J. David Spence

  352. Carotid endarterectomy--An evidence-based review: Report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology

    Article • Neurology, September 2005, Wolters Kluwer Health

    Prof. J. David Spence

  353. 3D Ultrasound Measurement of Change in Carotid Plaque Volume: A Tool for Rapid Evaluation of New Therapies

    Article • Stroke, August 2005, Wolters Kluwer Health

    Prof. J. David Spence

  354. Complications of Type 2 Diabetes Among Aboriginal Canadians: Prevalence and associated risk factors

    Article • Diabetes Care, July 2005, American Diabetes Association

    Prof. J. David Spence

  355. A comparison of ultrasound measurements to assess carotid atherosclerosis development in subjects with and without type 2 diabetes

    Article • Cardiovascular Ultrasound, June 2005, Springer Science + Business Media

    Prof. J. David Spence

  356. Vitamin B12, homocysteine and carotid plaque in the era of folic acid fortification of enriched cereal grain products

    Article • Canadian Medical Association Journal, June 2005, Canadian Medical Association (CMA)

    Prof. J. David Spence

  357. Quantification of carotid plaque volume measurements using 3D ultrasound imaging

    Article • Ultrasound in Medicine & Biology, June 2005, Elsevier

    Prof. J. David Spence

  358. Differences between carotid wall morphological phenotypes measured by ultrasound in one, two and three dimensions

    Article • Atherosclerosis, February 2005, Elsevier

    Prof. J. David Spence

  359. Anthropometric data for magnetic resonance imaging of the carotid bifurcation

    Article • Journal of Magnetic Resonance Imaging, January 2005, Wiley

    Prof. J. David Spence

  360. Carotid Ultrasound in One, Two and Three Dimensions

    Article • Vascular Disease Prevention, January 2005, Bentham Science Publishers

    Prof. J. David Spence

  361. Dimercaptosuccinic acid for the treatment of hyperhomocysteinemia in hemodialysis patients: A placebo-controlled, double-blind, randomized trial

    Article • October 2004, Elsevier

    Prof. J. David Spence

  362. The current epidemic of primary aldosteronism

    Article • Journal of Hypertension, October 2004, Wolters Kluwer Health

    Prof. J. David Spence

  363. Carotid intima-media thickness and cognitive decline: what does it mean for prevention of dementia?

    Article • Journal of the Neurological Sciences, August 2004, Elsevier

    Prof. J. David Spence

  364. Genetic Variation in PPARG Encoding Peroxisome Proliferator-Activated Receptor   Associated With Carotid Atherosclerosis

    Article • Stroke, July 2004, Wolters Kluwer Health

    Prof. J. David Spence

  365. Non-Invasive Assessment of Atherosclerosis Risk

    Article • Current Drug Targets - Cardiovascular & Hematological Disorders, June 2004, Bentham Science Publishers

    Prof. J. David Spence

  366. 3D Ultrasound Imaging of the Carotid Arteries

    Article • Current Drug Targets - Cardiovascular & Hematological Disorders, June 2004, Bentham Science Publishers

    Prof. J. David Spence

  367. Preventing Dementia by Treating Hypertension and Preventing Stroke

    Article • Hypertension, June 2004, Wolters Kluwer Health

    Prof. J. David Spence

  368. Single nucleotide polymorphism in CTH associated with variation in plasma homocysteine concentration

    Article • Clinical Genetics, April 2004, Wiley

    Prof. J. David Spence

  369. Measurement of Carotid Plaque Volume by 3-Dimensional Ultrasound

    Article • Stroke, February 2004, Wolters Kluwer Health

    Prof. J. David Spence

  370. Noninvasive Phenotypes of Atherosclerosis: Similar Windows but Different Views

    Article • Stroke, February 2004, Wolters Kluwer Health

    Prof. J. David Spence

  371. Lowering Homocysteine in Patients With Ischemic Stroke to Prevent Recurrent Stroke, Myocardial Infarction, and Death

    Article • February 2004, American Medical Association (AMA)

    Prof. J. David Spence

  372. Sex Differences in Carotid Plaque and Stenosis

    Article • Stroke, February 2004, Wolters Kluwer Health

    Prof. J. David Spence

  373. The Effect of Flax Seed Cultivars with Differing Content of α-Linolenic Acid and Lignans on Responses to Mental Stress

    Article • Journal of the American College of Nutrition, December 2003, Taylor & Francis

    Prof. J. David Spence

  374. Relationship Between Blood Pressure and Stroke Risk in Patients With Symptomatic Carotid Occlusive Disease

    Article • Stroke, October 2003, Wolters Kluwer Health

    Prof. J. David Spence

  375. Lipoprotein Lipase (LPL) Gene Variation and Progression of Carotid Artery Plaque

    Article • Stroke, April 2003, Wolters Kluwer Health

    Prof. J. David Spence

  376. Infection, Inflammation, and Atherosclerosis

    Article • Stroke, February 2003, Wolters Kluwer Health

    Prof. J. David Spence

  377. Measurement of Carotid Plaque and Effect of Vitamin Therapy for Total Homocysteine

    Article • January 2003, De Gruyter

    Prof. J. David Spence

  378. Carotid Plaque Area: A Tool for Targeting and Evaluating Vascular Preventive Therapy

    Article • Stroke, November 2002, Wolters Kluwer Health

    Prof. J. David Spence

  379. Article • Journal of Cardiovascular Risk, August 2002, Wolters Kluwer Health

    Prof. J. David Spence

  380. Treatment options for renovascular hypertension

    Article • Expert Opinion on Pharmacotherapy, April 2002, Informa Healthcare

    Prof. J. David Spence

  381. Grapefruit juice-drug interactions

    Article • British Journal of Clinical Pharmacology, January 2002, Wiley

    Prof. J. David Spence

  382. Reconstruction of carotid bifurcation hemodynamics and wall thickness using computational fluid dynamics and MRI

    Article • Magnetic Resonance in Medicine, December 2001, Wiley

    Prof. J. David Spence

  383. Knowledge gaps

    Article • December 2001, Elsevier

    Prof. J. David Spence

  384. Actual practice in hypertension: Implications for persistence with and effectiveness of therapy

    Article • Current Hypertension Reports, November 2001, Springer Science + Business Media

    Prof. J. David Spence

  385. Endarterectomy or angioplasty for treatment of carotid stenosis?

    Article • June 2001, Elsevier

    Prof. J. David Spence

  386. Homocyst(e)ine, nitrous oxide and atherosclerosis

    Article • Best Practice & Research Clinical Anaesthesiology, June 2001, Elsevier

    Prof. J. David Spence

  387. Improved Outcomes in Stroke Thrombolysis with Pre-specified Imaging Criteria

    Article • Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques, May 2001, Cambridge University Press

    Prof. J. David Spence

  388. Patients With Atherosclerotic Vascular Disease

    Article • January 2001, Springer Science + Business Media

    Prof. J. David Spence

  389. Vitamin Intervention for Stroke Prevention (VISP) Trial: Rationale and Design

    Article • Neuroepidemiology, January 2001, Karger Publishers

    Prof. J. David Spence

  390. Effect of amlodipine on hemodynamic and endocrine responses to mental stress

    Article • American Journal of Hypertension, May 2000, Oxford University Press (OUP)

    Prof. J. David Spence

  391. Angiotensin II antagonists for hypertension: are there differences in efficacy?

    Article • April 2000, Oxford University Press (OUP)

    Prof. J. David Spence

  392. Hypocholesterolemic effects of dietary citrus juices in rabbits

    Article • Nutrition Research, January 2000, Elsevier

    Prof. J. David Spence

  393. Management of Resistant Hypertension in Patients with Carotid Stenosis: High Prevalence of Renovascular Hypertension

    Article • Cerebrovascular Diseases, January 2000, Karger Publishers

    Prof. J. David Spence

  394. What level of plasma homocyst(e)ine should be treated? Effects of vitamin therapy on progression of carotid atherosclerosis in patients with homocyst(e)ine levels above and below 14 μmol/L

    Article • January 2000, Oxford University Press (OUP)

    Prof. J. David Spence

  395. Pharmacokinetic-Pharmacodynamic Consequences and Clinical Relevance of Cytochrome P450 3A4 Inhibition

    Article • Clinical Pharmacokinetics, January 2000, Springer Science + Business Media

    Prof. J. David Spence

  396. Contents of Related Journals

    Article • November 1999, Oxford University Press (OUP)

    Prof. J. David Spence

  397. Serum metabolism of bradykinin and des-Arg9-bradykinin in patients with angiotensin-converting enzyme inhibitor-associated angioedema

    Article • Immunopharmacology, September 1999, Elsevier

    Prof. J. David Spence

  398. An approach to ascertain probands with a non-traditional risk factor for carotid atherosclerosis

    Article • Atherosclerosis, June 1999, Elsevier

    Prof. J. David Spence

  399. Low-dose and high-dose acetylsalicylic acid for patients undergoing carotid endarterectomy: a randomised controlled trial

    Article • June 1999, Elsevier

    Prof. J. David Spence

  400. Effect of Usual Doses of Folate Supplementation on Elevated Plasma Homocyst(e)ine in Hemodialysis Patients: No Difference between 1 and 5 mg Daily

    Article • American Journal of Nephrology, January 1999, Karger Publishers

    Prof. J. David Spence

  401. Benefit of Carotid Endarterectomy in Patients with Symptomatic Moderate or Severe Stenosis

    Article • New England Journal of Medicine, November 1998, New England Journal of Medicine (NEJM/MMS)

    Prof. J. David Spence

  402. Editorial commentary

    Article • Journal of Stroke and Cerebrovascular Diseases, May 1998, Elsevier

    Prof. J. David Spence

  403. Carotid Endarterectomy Does Not Affect Long-Term Blood Pressure: Observations from the NASCET

    Article • Cerebrovascular Diseases, January 1998, Karger Publishers

    Prof. J. David Spence

  404. Clinical Pharmacokinetics of Fibric Acid Derivatives (Fibrates)

    Article • January 1998, Springer Science + Business Media

    Prof. J. David Spence

  405. Metabolism of Fibric Acid Derivatives

    Article • January 1998, Springer Science + Business Media

    Prof. J. David Spence

  406. Informing the public

    Article • Clinical Pharmacology & Therapeutics, November 1997, Springer Science + Business Media

    Prof. J. David Spence

  407. Pseudo-hypertension in the elderly: still hazy, after all these years

    Article • Journal of Human Hypertension, October 1997, Springer Science + Business Media

    Prof. J. David Spence

  408. Correspondence

    Article • May 1997, Oxford University Press (OUP)

    Prof. J. David Spence

  409. Grapefruit juice—terfenadine single-dose interaction: Magnitude, mechanism, and relevance*

    Article • Clinical Pharmacology & Therapeutics, April 1997, Springer Science + Business Media

    Prof. J. David Spence

  410. Psychological stress and the progression of carotid artery disease

    Article • Journal of Hypertension, January 1997, Wolters Kluwer Health

    Prof. J. David Spence

  411. Erythromycin-felodipine interaction: Magnitude, mechanism, and comparison with grapefruit juice*

    Article • Clinical Pharmacology & Therapeutics, July 1996, Nature

    Prof. J. David Spence

  412. The acetylcholinesterase oxime reactivator HI-6 in man: Pharmacokinetics and tolerability in combination with atropine

    Article • Biopharmaceutics & Drug Disposition, July 1995, Wiley

    Prof. J. David Spence

  413. Government guidelines for treatment of hypertension

    Article • May 1995, Oxford University Press (OUP)

    Prof. J. David Spence

  414. Prognosis for Patients Following a Transient Ischemic Attack With and Without a Cerebral Infarction on Brain CT

    Article • Neurology, March 1995, Wolters Kluwer Health

    Prof. J. David Spence

  415. Grapefruit Juice and Drugs

    Article • Clinical Pharmacokinetics, February 1994, Springer Science + Business Media

    Prof. J. David Spence

  416. Effect of grapefruit juice and naringin on nisoldipine pharmacokinetics

    Article • Clinical Pharmacology & Therapeutics, December 1993, Springer Science + Business Media

    Prof. J. David Spence

  417. Grapefruit juice–felodipine interaction: Mechanism, predictability, and effect of naringin

    Article • Clinical Pharmacology & Therapeutics, June 1993, Springer Science + Business Media

    Prof. J. David Spence

  418. Differences in metabolism of time-release and unmodified nicotinic acid: Explanation of the differences in hypolipidemic action?

    Article • Metabolism, August 1992, Elsevier

    Prof. J. David Spence

  419. Tests for renal vascular disease

    Article • August 1992, Elsevier

    Prof. J. David Spence

  420. Beneficial Effect of Carotid Endarterectomy in Symptomatic Patients with High-Grade Carotid Stenosis

    Article • New England Journal of Medicine, August 1991, New England Journal of Medicine (NEJM/MMS)

    Prof. J. David Spence

  421. Interaction of citrus juices with felodipine and nifedipine

    Article • The Lancet, February 1991, Elsevier

    Prof. J. David Spence

  422. Intramuscular administration of iron during long-term chelation therapy with 2,3-dimercaptosuccinic acid in a man with severe lead poisoning

    Article • Clinical Biochemistry, June 1989, Elsevier

    Prof. J. David Spence

  423. Measurement of Atherosclerosis: Development of an Atherosclerosis Severity Index

    Article • Clinical and Experimental Hypertension Part A Theory and Practice, January 1989, Taylor & Francis

    Prof. J. David Spence

  424. EFFECT OF NON-STEROIDAL ANTI-INFLAMMATORY DRUGS ON CONTROL OF HYPERTENSION BY BETA-BLOCKERS AND DIURETICS

    Article • May 1986, Elsevier

    Prof. J. David Spence

  425. Evaluation of once daily endralazine in hypertension

    Article • European Journal of Clinical Pharmacology, January 1986, Springer Science + Business Media

    Prof. J. David Spence

  426. The arthritic patient with hypertension: Selection of an NSAID

    Article • Scandinavian Journal of Rheumatology, January 1986, Taylor & Francis

    Prof. J. David Spence

  427. Hypertension in Acute Ischemic Strokes

    Article • Archives of Neurology, October 1985, American Medical Association (AMA)

    Prof. J. David Spence

  428. EFFECTS OF TRIAMTERENE AND AMILORIDE ON URINARY SEDIMENT IN HYPERTENSIVE PATIENTS TAKING HYDROCHLOROTHIAZIDE

    Article • July 1985, Elsevier

    Prof. J. David Spence

  429. Blood Pressure Measurement in the Elderly: Correlation of Arterial Stiffness with Difference Between Intra-arterial and Cuff Pressures

    Article • Journal of Hypertension, June 1985, Wolters Kluwer Health

    Prof. J. David Spence

  430. Spectrum of benign intracranial hypertension in children and adolescents

    Article • Child s Nervous System, January 1985, Springer Science + Business Media

    Prof. J. David Spence

  431. Hemodynamic modification of aortic atherosclerosis

    Article • Atherosclerosis, March 1984, Elsevier

    Prof. J. David Spence

  432. Potassium-sparing Diuretics: Interaction with Digoxin in Elderly Men

    Article • February 1984, Wiley

    Prof. J. David Spence

  433. Phenytoin-Theophylline Interaction

    Article • New England Journal of Medicine, November 1982, New England Journal of Medicine (NEJM/MMS)

    Prof. J. David Spence

  434. Pseudohypertension in the Elderly

    Article • Clinical Science, January 1978, Portland Press Ltd.

    Prof. J. David Spence

  435. Vitamins and antioxidants

    Article • Taylor & Francis

    Prof. J. David Spence