All Stories

  1. Toxicity and Local Tolerance of COVID- eVax, a Plasmid DNA Vaccine for SARS-CoV-2, Delivered by Electroporation

    Article • Toxicologic Pathology, September 2021, SAGE Publications

    dr gianfranco caselli

  2. Improved efficacy, tolerance, safety, and abuse liability profile of the combination of CR4056 and morphine over morphine alone in rodent models

    Article • British Journal of Pharmacology, April 2020, Wiley

    dr gianfranco caselli

  3. A new mechanism of action for a pain killer drug

    Article • British Journal of Pharmacology, August 2019, Wiley

    dr gianfranco caselli

  4. Pharmacological characterisation of CR6086, a potent prostaglandin E2 receptor 4 antagonist, as a new potential disease-modifying anti-rheumatic drug

    Article • March 2018, Springer Science + Business Media

    dr gianfranco caselli

  5. Poly-histidine grafting leading to fishbone-like architectures

    Article • RSC Advances, January 2018, Royal Society of Chemistry

    dr gianfranco caselli

  6. CR4056, a first-in-class Imidazoline I2 ligand, counteracts osteoarthritis chronic pain in rats

    Article • Journal of Pain Research, May 2017, Dove Medical Press

    dr gianfranco caselli, Marco Lanza

  7. Multivalent ligands for the serotonin 5-HT4 receptor

    Article • MedChemComm, January 2017, Royal Society of Chemistry

    dr gianfranco caselli

  8. Phenylindenone isomers as divergent modulators of p38α MAP kinase

    Article • Bioorganic & Medicinal Chemistry Letters, November 2016, Elsevier

    dr gianfranco caselli

  9. Supramolecular Glycodendrimer-Based Hybrid Drugs

    Article • Biomacromolecules, October 2014, American Chemical Society (ACS)

    dr gianfranco caselli

  10. Modulation of imidazoline I2 binding sites by CR4056 relieves postoperative hyperalgesia in male and female rats

    Article • British Journal of Pharmacology, July 2014, Wiley

    Dr Marco Lanza, dr gianfranco caselli

  11. Synthesis and structure–activity relationship studies in serotonin 5-HT4 receptor ligands based on a benzo[de][2,6]naphthridine scaffold

    Article • European Journal of Medicinal Chemistry, July 2014, Elsevier

    dr gianfranco caselli

  12. Dendrimeric tetravalent ligands for the serotonin-gated ion channel

    Article • Chemical Communications, June 2014, Royal Society of Chemistry

    Professor Andrea Cappelli, dr gianfranco caselli

  13. The novel anti-inflammatory agent VA694, endowed with both NO-releasing and COX2-selective inhibiting properties, exhibits NO-mediated positive effects on blood pressure, coronary flow and endothelium in an experimental model of hypertension and endoth...

    Article • Pharmacological Research, December 2013, Elsevier

    dr gianfranco caselli

  14. Targeting of ADAMTS5's ancillary domain with the recombinant mAb CRB0017 ameliorates disease progression in a spontaneous murine model of osteoarthritis

    Article • Osteoarthritis and Cartilage, November 2013, Elsevier

    dr gianfranco caselli

  15. Exploring Multitarget Interactions to Reduce Opiate Withdrawal Syndrome and Psychiatric Comorbidity

    Article • ACS Medicinal Chemistry Letters, July 2013, American Chemical Society (ACS)

    dr gianfranco caselli

  16. Synthesis and structure–activity relationship studies in serotonin 5-HT1A receptor agonists based on fused pyrrolidone scaffolds

    Article • European Journal of Medicinal Chemistry, May 2013, Elsevier

    Dr sandra gemma, Dr Simone Brogi, Dr Stefania Butini, dr gianfranco caselli

  17. Discovery, synthesis, selectivity modulation and DMPK characterization of 5-azaspiro[2.4]heptanes as potent orexin receptor antagonists

    Article • Bioorganic & Medicinal Chemistry Letters, May 2013, Elsevier

    dr gianfranco caselli

  18. Silibinin hemisuccinate binding to proteins in plasma and blood cell/plasma partitioning in mouse, rat, dog and man in vitro

    Article • Drug Metabolism and Drug Interactions, January 2013, De Gruyter

    dr gianfranco caselli

  19. CR4056, a new analgesic I2 ligand, is highly effective against bortezomib-induced painful neuropathy in rats

    Article • Journal of Pain Research, June 2012, Taylor & Francis

    Marco Lanza, dr gianfranco caselli

  20. Synthesis, pharmacophore modeling and in vitro activity of 10,11-dihydrodibenzo[b,f]oxepine-4-carboxamide derivatives as novel and potent antagonists of the prostaglandin EP4 receptor

    Article • Bioorganic & Medicinal Chemistry Letters, November 2011, Elsevier

    dr gianfranco caselli

  21. Analgesic efficacy of CR4056, a novel imidazoline-2 receptor ligand, in rat models of inflammatory and neuropathic pain

    Article • Journal of Pain Research, April 2011, Taylor & Francis

    Marco Lanza, dr gianfranco caselli

  22. Experimental Pharmacology of Glucosamine Sulfate

    Article • International Journal of Rheumatology, January 2011, Hindawi Publishing Corporation

    dr gianfranco caselli

  23. Antipsychotic-like effects of the N-methyl-d-aspartate receptor modulator neboglamine: An immunohistochemical and behavioural study in the rat

    Article • Pharmacological Research, May 2010, Elsevier

    dr gianfranco caselli

  24. Design, Synthesis, and Preliminary Biological Evaluation of Pyrrolo[3,4-c]quinolin-1-one and Oxoisoindoline Derivatives as Aggrecanase Inhibitors

    Article • ChemMedChem, April 2010, Wiley

    dr gianfranco caselli

  25. Efficacy of CR3294, a new benzamidine derivative, in the prevention of 5-fluorouracil-induced gastrointestinal mucositis and diarrhea in mice

    Article • Cancer Chemotherapy and Pharmacology, December 2009, Springer Science + Business Media

    dr gianfranco caselli

  26. Multivalent Supramolecular Dendrimer-Based Drugs

    Article • Biomacromolecules, December 2009, American Chemical Society (ACS)

    dr gianfranco caselli

  27. Glutamate signaling in chondrocytes and the potential involvement of NMDA receptors in cell proliferation and inflammatory gene expression

    Article • Osteoarthritis and Cartilage, August 2009, Elsevier

    dr gianfranco caselli

  28. Progress Towards the Identification of New Aggrecanase Inhibitors

    Article • Current Medicinal Chemistry, July 2009, Bentham Science Publishers

    dr gianfranco caselli

  29. Andolast Acts at Different Cellular Levels to Inhibit Immunoglobulin E Synthesis

    Article • International Journal of Immunopathology and Pharmacology, January 2009, SAGE Publications

    dr gianfranco caselli

  30. Induction of autophagic cell death by a novel molecule Is increased by hypoxia

    Article • Autophagy, November 2008, Taylor & Francis

    Dr Corrado Spadafora, dr gianfranco caselli

  31. Pharmacokinetic study of a new angiotensin-AT1 antagonist by HPLC

    Article • Journal of Pharmaceutical and Biomedical Analysis, September 2008, Elsevier

    dr gianfranco caselli

  32. In vivo neurochemical effects of the NR2B selective NMDA receptor antagonist CR 3394 in 6-hydroxydopamine lesioned rats

    Article • European Journal of Pharmacology, April 2008, Elsevier

    dr gianfranco caselli

  33. Design, Synthesis, and Biological Evaluation of AT1 Angiotensin II Receptor Antagonists Based on the Pyrazolo[3,4-b]pyridine and Related Heteroaromatic Bicyclic Systems

    Article • Journal of Medicinal Chemistry, March 2008, American Chemical Society (ACS)

    dr gianfranco caselli

  34. Functional in vitro characterization of CR 3394: A novel voltage dependent N-methyl-d-aspartate (NMDA) receptor antagonist

    Article • Neuropharmacology, March 2006, Elsevier

    dr gianfranco caselli

  35. Pharmacological profile of CR3465, a new leukotriene CysLT1 receptor antagonist with broad anti-inflammatory activity

    Article • European Journal of Pharmacology, November 2004, Elsevier

    dr gianfranco caselli

  36. IL-18 cDNA vaccination protects mice from spontaneous lupus-like autoimmune disease

    Article • Proceedings of the National Academy of Sciences, November 2003, Proceedings of the National Academy of Sciences

    dr gianfranco caselli

  37. An HGF–MSP chimera disassociates the trophic properties of scatter factors from their pro-invasive activity

    Article • Nature Biotechnology, May 2002, Springer Science + Business Media

    dr gianfranco caselli

  38. In Vitro Permeation Screening of a New Formulation of Thiocolchicoside Containing Various Enhancers

    Article • Drug Delivery, January 2002, Taylor & Francis

    dr gianfranco caselli

  39. Role of tumor necrosis factor-alpha in endotoxin-induced lung parenchymal hyporesponsiveness in mice11Abbreviations: BALF, bronchoalveolar lavage fluid; 5-HT, 5-hydroxytryptamine; IL-, interleukin-; IL-1RA, interleukin-1 receptor antagonist; LPS, lipop...

    Article • Biochemical Pharmacology, November 2001, Elsevier

    dr gianfranco caselli

  40. Selective inhibition of interleukin-8-induced neutrophil chemotaxis by ketoprofen isomers 11Abbreviations: NSAIDs, non-steroidal anti-inflammatorydrugs; COX, cyclooxygenase; PG, prostaglandin; PMN, humanpolymorphonuclear leukocyte; IL-8, interleukin-8;...

    Article • Biochemical Pharmacology, June 2001, Elsevier

    dr gianfranco caselli

  41. LPS INDUCES IL-6 IN THE BRAIN AND IN SERUM LARGELY THROUGH TNF PRODUCTION

    Article • Cytokine, August 2000, Elsevier

    dr gianfranco caselli

  42. Lipopolysaccharide-induced Lung Injury in Mice. I. Concomitant Evaluation of Inflammatory Cells and Haemorrhagic Lung Damage

    Article • Pulmonary Pharmacology & Therapeutics, April 2000, Elsevier

    dr gianfranco caselli

  43. Lipopolysaccharide-induced Lung Injury in Mice. II. Evaluation of Functional Damage in Isolated Parenchyma Strips

    Article • Pulmonary Pharmacology & Therapeutics, April 2000, Elsevier

    dr gianfranco caselli

  44. Synthesis, inhibitory activity towards human leukocyte elastase and molecular modelling studies of 1-carbamoyl-4-methyleneaminoxyazetidinones

    Article • European Journal of Medicinal Chemistry, January 2000, Elsevier

    dr gianfranco caselli

  45. Does Colchicine Really Induce Bone Formation in the Rodent Bone Marrow? Yes, it Does

    Article • Calcified Tissue International, November 1999, Springer Science + Business Media

    dr gianfranco caselli

  46. Peripheral blood mononuclear cell production of interleukin-8 and IL-8-dependent neutrophil function in hypercholesterolemic patients

    Article • Atherosclerosis, October 1999, Elsevier

    Professor Marcela Reale, dr gianfranco caselli

  47. Thioredoxin, a Redox Enzyme Released in Infection and Inflammation, Is a Unique Chemoattractant for Neutrophils, Monocytes, and T Cells

    Article • The Journal of Experimental Medicine, June 1999, Rockefeller University Press

    Professor Gurunath Ramanathan, dr gianfranco caselli

  48. Synthesis and in vitro and in vivo evaluation of the 2-(6′methoxy-3′,4′-dihydro-1′-naphtyl)-4H-3,1-benzoxazin-4-one as a new potent substrate inhibitor of human leukocyte elastase

    Article • Bioorganic & Medicinal Chemistry Letters, May 1999, Elsevier

    dr gianfranco caselli

  49. EFFICACY OF A NEW TOPICAL GEL-SPRAY FORMULATION OF KETOPROFEN LYSINE SALT IN THE RAT: PERCUTANEOUS PERMEATIONIN VITROANDIN VIVOAND PHARMACOLOGICAL ACTIVITY

    Article • Pharmacological Research, January 1998, Elsevier

    dr gianfranco caselli

  50. Tartronates: A New Generation of Drugs Affecting Bone Metabolism

    Article • Journal of Bone and Mineral Research, June 1997, Wiley

    dr gianfranco caselli

  51. KETOPROFEN LYSINE SALT INHIBITS DISUSE-INDUCED OSTEOPENIA IN A NEW NON-TRAUMATIC IMMOBILIZATION MODEL IN THE RAT

    Article • Pharmacological Research, April 1996, Elsevier

    dr gianfranco caselli

  52. IL-1β primes IL-8-activated human neutrophils for elastase release, phospholipase D activity, and calcium flux

    Article • Journal of Leukocyte Biology, March 1996, Wiley

    dr gianfranco caselli

  53. Effectiveness of carbocysteine lysine salt monohydrate on models of airway inflammation and hyperresponsiveness

    Article • Pharmacological Research, June 1995, Elsevier

    dr gianfranco caselli

  54. Heterogeneity of [3H]-mepyramine binding sites in guinea pig cerebellum and lung

    Article • Agents and Actions, May 1991, Springer Science + Business Media

    dr gianfranco caselli

  55. Determination of Nuvenzepine in Human Plasma by a Sensitive [3H]Pirenzepine Radioreceptor Binding Assay

    Article • Journal of Pharmaceutical Sciences, February 1991, Elsevier

    dr gianfranco caselli

  56. Antihistaminic/antiallergic activity of 2-dialkylaminoalkylthio(oxy)-1-substituted benzimidazoles: Evaluation “in vitro” and “in vivo”

    Article • Agents and Actions, April 1990, Springer Science + Business Media

    dr gianfranco caselli

  57. Antihistaminic/antiallergic activity of 2-dialkylaminoalkylthio(OXY) 1-substituted benzimidazoles, evaluation “In vitro” and “In vivo”

    Article • Pharmacological Research Communications, September 1988, Elsevier

    dr gianfranco caselli

  58. Effects of of 545 on different ulcer models in rats

    Article • Pharmacological Research Communications, September 1988, Elsevier

    dr gianfranco caselli

  59. Pharmacokinetic profile of [14C]-DF 545 after single P.O. and I.V. administration in rats

    Article • Pharmacological Research Communications, September 1988, Elsevier

    dr gianfranco caselli

  60. Spasmolytic and antiulcer activities of a new series of antimuscarinic compounds

    Article • Pharmacological Research Communications, September 1988, Elsevier

    dr gianfranco caselli

  61. Prostaglandins and lipolysis I: PGI2 formation by rat epididymal adipose tissue artery

    Article • Pharmacological Research Communications, September 1981, Elsevier

    dr gianfranco caselli