All Stories

  1. Soma to germline inheritance of extrachromosomal genetic information via a LINE-1 reverse transcriptase-based mechanism

    Article • BioEssays, June 2016, Wiley

    Dr Corrado Spadafora

  2. A LINE-1-encoded reverse transcriptase-dependent regulatory mechanism is active in embryogenesis and tumorigenesis

    Article • Annals of the New York Academy of Sciences, January 2015, Wiley

    Dr Corrado Spadafora

  3. Soma-to-Germline Transmission of RNA in Mice Xenografted with Human Tumour Cells: Possible Transport by Exosomes

    Article • PLoS ONE, July 2014, PLOS

    Dr Corrado Spadafora

  4. LINE-1 retrotransposon copies are amplified during murine early embryo development

    Article • Molecular Reproduction and Development, December 2011, Wiley

    Dr Corrado Spadafora

  5. Modulation of Cell Differentiation, Proliferation, and Tumor Growth by Dihydrobenzyloxopyrimidine Non-Nucleoside Reverse Transcriptase Inhibitors

    Article • Journal of Medicinal Chemistry, August 2011, American Chemical Society (ACS)

    Dr Corrado Spadafora

  6. A Reverse Transcriptase-Dependent Mechanism Is Essential for Murine Preimplantation Development

    Article • Genes, May 2011, MDPI AG

    Dr Corrado Spadafora

  7. Retrotransposon-Encoded Reverse Transcriptase in the Genesis, Progression and Cellular Plasticity of Human Cancer

    Article • Cancers, March 2011, MDPI AG

    Dr Corrado Spadafora, Dr. Claudia Matteucci

  8. Retrotransposons, reverse transcriptase and the genesis of new genetic information

    Article • Gene, December 2009, Elsevier

    Dr Corrado Spadafora

  9. Induction of autophagic cell death by a novel molecule Is increased by hypoxia

    Article • Autophagy, November 2008, Taylor & Francis

    Dr Corrado Spadafora, dr gianfranco caselli

  10. A Reverse Transcriptase-Dependent Mechanism Plays Central Roles in Fundamental Biological Processes

    Article • Systems Biology in Reproductive Medicine, January 2008, Taylor & Francis

    Dr Corrado Spadafora

  11. New Genetic Information Generated by Endogenous Reverse Transcription in Sperm Cells

    Article • March 2007, Royal Society of Chemistry

    Dr Corrado Spadafora

  12. Anti-Tumor Activity of Non-Nucleosidic Reverse Transcriptase Inhibitors

    Article • Current Pharmaceutical Design, March 2007, Bentham Science Publishers

    Dr Corrado Spadafora

  13. 6-Alkylthio-4-[1-(2,6-difluorophenyl)alkyl]-1H-[1,3,5]triazin-2-ones (ADATs): Novel Regulators of Cell Differentiation and Proliferation

    Article • ChemMedChem, October 2006, Wiley

    Dr Corrado Spadafora

  14. Expression of LINE-1 retroposons is essential for murine preimplantation development

    Article • Molecular Reproduction and Development, March 2006, Wiley

    Dr Corrado Spadafora

  15. Generation of biologically active retro-genes upon interaction of mouse spermatozoa with exogenous DNA

    Article • Molecular Reproduction and Development, January 2006, Wiley

    Dr Corrado Spadafora

  16. 6-[1-(2,6-Difluorophenyl)ethyl]pyrimidinones Antagonize Cell Proliferation and Induce Cell Differentiation by Inhibiting (a Nontelomeric) Endogenous Reverse Transcriptase

    Article • Journal of Medicinal Chemistry, November 2005, American Chemical Society (ACS)

    Dr Corrado Spadafora

  17. Reverse Transcriptase Inhibitors Down-Regulate Cell Proliferationin Vitroandin Vivoand Restore Thyrotropin Signaling and Iodine Uptake in Human Thyroid Anaplastic Carcinoma

    Article • The Journal of Clinical Endocrinology & Metabolism, October 2005, Endocrine Society

    Dr Corrado Spadafora, Annamaria Piscazzi

  18. Inhibition of endogenous reverse transcriptase antagonizes human tumor growth

    Article • Oncogene, April 2005, Springer Science + Business Media

    Dr Corrado Spadafora

  19. Sperm-mediated gene transfer: Applications and implications

    Article • BioEssays, January 2005, Wiley

    Dr Corrado Spadafora

  20. A role for endogenous reverse transcriptase in tumorigenesis and as a target in differentiating cancer therapy

    Article • Genes Chromosomes and Cancer, January 2005, Wiley

    Dr Corrado Spadafora

  21. Sperm endogenous reverse transcriptase as mediator of new genetic information

    Article • Biochemical and Biophysical Research Communications, December 2003, Elsevier

    Dr Corrado Spadafora

  22. Role of endogenous reverse transcriptase in murine early embryo development

    Article • Molecular Reproduction and Development, September 2003, Wiley

    Dr Corrado Spadafora

  23. Mouse early embryos obtained by natural breeding or in vitro fertilization display a differential sensitivity to extremely low-frequency electromagnetic fields

    Article • Mutation Research/Genetic Toxicology and Environmental Mutagenesis, July 2003, Elsevier

    Dr Corrado Spadafora

  24. Specific localization of transcription factors in the chromatin of mouse mature spermatozoa

    Article • Molecular Reproduction and Development, January 2001, Wiley

    Dr Corrado Spadafora

  25. E2F transcription factors are differentially expressed in murine gametes and early embryos

    Article • Mechanisms of Development, October 2000, Elsevier

    Dr Corrado Spadafora

  26. Cloning of PC3B, a Novel Member of the PC3/BTG/TOB Family of Growth Inhibitory Genes, Highly Expressed in the Olfactory Epithelium

    Article • Genomics, September 2000, Elsevier

    Dr Corrado Spadafora, Dr Felice Tirone

  27. Conclusions

    Article • Molecular Reproduction and Development, June 2000, Wiley

    Dr Corrado Spadafora

  28. Nucleosomal domains of mouse spermatozoa chromatin as potential sites for retroposition and foreign DNA integration

    Article • Molecular Reproduction and Development, June 2000, Wiley

    Dr Corrado Spadafora

  29. DNA dose and sequence dependence in sperm-mediated gene transfer

    Article • Molecular Reproduction and Development, June 2000, Wiley

    Dr Corrado Spadafora

  30. Sperm cells and foreign DNA: a controversial relation

    Article • BioEssays, December 1998, Wiley

    Dr Corrado Spadafora

  31. Sperm cells and foreign DNA: a controversial relation

    Article • BioEssays, November 1998, Wiley

    Dr Corrado Spadafora

  32. Sperm-mediated gene transfer in mice

    Article • Molecular Reproduction and Development, August 1998, Wiley

    Dr Corrado Spadafora

  33. Sperm‐mediated gene transfer in mice

    Article • Molecular Reproduction and Development, August 1998, Wiley

    Dr Corrado Spadafora

  34. Sperm-Mediated Gene Transfer

    Article • January 1998, Springer Science + Business Media

    Dr Corrado Spadafora

  35. Integration of Foreign DNA Sequences into Mouse Sperm Genome

    Article • DNA and Cell Biology, March 1997, Mary Ann Liebert Inc

    Dr Corrado Spadafora

  36. Evidence for nuclear internalization of exogenous DNA into mammalian sperm cells

    Article • Molecular Reproduction and Development, February 1993, Wiley

    Dr Corrado Spadafora

  37. Letter to the editor

    Article • Cell, October 1989, Elsevier

    Dr Corrado Spadafora

  38. Sperm cells as vectors for introducing foreign DNA into eggs: Genetic transformation of mice

    Article • Cell, June 1989, Elsevier

    Dr Corrado Spadafora

  39. Different conformations of ribosomal DNA in active and inactive chromatin in Xenopus laevis

    Article • Journal of Molecular Biology, December 1985, Elsevier

    Dr Corrado Spadafora

  40. Compact structure of ribosomal chromatin in Xenopus laevis

    Article • Nucleic Acids Research, January 1984, Oxford University Press (OUP)

    Dr Corrado Spadafora

  41. Cloning and characterization of the ribosomal genes of the sea-urchin Paracentrotus lividus. Heterogeneity of the multigene family

    Article • European Journal of Biochemistry, December 1983, Wiley

    Dr Corrado Spadafora

  42. Rearrangement of Chromatin Structure Induced by Increasing Ionic Strength and Temperature

    Article • European Journal of Biochemistry, October 1979, Wiley

    Dr Corrado Spadafora

  43. The same amount of DNA is organized in in vitro-assembled nucleosomes irrespective of the origin of the histones

    Article • Nucleic Acids Research, January 1978, Oxford University Press (OUP)

    Dr Corrado Spadafora

  44. Chromatin organization in nuclei of sea urchin embryos. Comparison with the chromatin organization of the sperm

    Article • Cell Differentiation, December 1976, Elsevier

    Dr Corrado Spadafora

  45. The DNA repeat lengths in chromatins from sea urchin sperm and gastrula cells are markedly different

    Article • FEBS Letters, October 1976, Wiley

    Dr Corrado Spadafora

  46. A site of discontinuity in the interaction between DNA and histones in nucleosomes of sea urchin embryo chromatin

    Article • Biochemical and Biophysical Research Communications, March 1976, Elsevier

    Dr Corrado Spadafora

  47. The subunit structure of sea urchin sperm chromatin: A kinetic approach

    Article • FEBS Letters, September 1975, Wiley

    Dr Corrado Spadafora

  48. Changes in transfer RNAs and aminoacyl-tRNA synthetases during sea urchin development

    Article • Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, July 1973, Elsevier

    Dr Corrado Spadafora

  49. Sperm-Mediated Transgenesis: Practical Implications of a Biological Process

    Article • Graft, Portico

    Dr Corrado Spadafora