All Stories

  1. Deficiency of immunoregulatory indoleamine 2,3-dioxygenase 1in juvenile diabetes

    Article • JCI Insight, March 2018, American Society for Clinical Investigation

    Professor FRANCESCA FALLARINO

  2. Interaction of 7-Alkoxycoumarins with the Aryl Hydrocarbon Receptor

    Article • Journal of Natural Products, May 2017, American Chemical Society (ACS)

    Professor FRANCESCA FALLARINO

  3. PCSK9 at the crossroad of cholesterol metabolism and immune function during infections

    Article • Journal of Cellular Physiology, January 2017, Wiley

    Professor FRANCESCA FALLARINO

  4. Neopterin and tryptophan breakdown in medical biochemistry, workshop abstracts

    Article • Pteridines, January 2017, De Gruyter

    PhD Dietmar N Fuchs, Assoc. Prof. Dr. Ayse Basak Engin, Professor FRANCESCA FALLARINO, Dr Simon Lytton, PhD Sabrina Sailer, Professor Hande Sipahi , Maria Kitchen, Teodor Postolache, Bernadette Vötter, Mariana Najjar, ALine Dagdag, Friedrich Leblhuber

  5. Distinct roles of immunoreceptor tyrosine-based motifs in immunosuppressive indoleamine 2,3-dioxygenase 1

    Article • Journal of Cellular and Molecular Medicine, September 2016, Wiley

    Professor FRANCESCA FALLARINO

  6. Xenograft of microencapsulated Sertoli cells restores glucose homeostasis in db/db mice with spontaneous diabetes mellitus

    Article • Xenotransplantation, September 2016, Wiley

    Professor FRANCESCA FALLARINO

  7. Effects of a nutraceutical combination on lipids, inflammation and endothelial integrity in patients with subclinical inflammation: a randomized clinical trial

    Article • Scientific Reports, March 2016, Springer Science + Business Media

    Professor FRANCESCA FALLARINO

  8. Aryl Hydrocarbon Receptor-Dependent Pathways in Immune Regulation

    Article • American Journal of Transplantation, March 2016, Wiley

    Professor FRANCESCA FALLARINO

  9. Allosteric modulation of metabotropic glutamate receptor 4 activates IDO1-dependent, immunoregulatory signaling in dendritic cells

    Article • Neuropharmacology, March 2016, Elsevier

    Professor FRANCESCA FALLARINO

  10. IDO1 Deficiency Does Not Affect Disease in Mouse Models of Systemic Juvenile Idiopathic Arthritis and Secondary Hemophagocytic Lymphohistiocytosis

    Article • PLoS ONE, February 2016, PLOS

    Professor FRANCESCA FALLARINO

  11. Azithromycin protects mice against ischemic stroke injury by promoting macrophage transition towards M2 phenotype

    Article • Experimental Neurology, January 2016, Elsevier

    Professor Diana Amantea, Professor FRANCESCA FALLARINO, Prof Giacinto Bagetta

  12. caffeine

    Article • Pteridines, January 2016, De Gruyter

    Professor Steven Paul Gieseg, Mrs Saziye Sezin Palabiyik, Professor FRANCESCA FALLARINO, Assoc. Prof. Dr. Ayse Basak Engin, PhD Sabrina Sailer, PhD Dietmar N Fuchs, Professor Hande Sipahi , Jaroslav Galba, Teodor Postolache, Friedrich Leblhuber

  13. Intraperitoneal injection of microencapsulated Sertoli cells restores muscle morphology and performance in dystrophic mice

    Article • Biomaterials, January 2016, Elsevier

    Prof stefano giovagnoli, Professor FRANCESCA FALLARINO

  14. Delineating the Role of Toll-Like Receptors in the Neuro-inflammation Model EAE

    Article • January 2016, Springer Science + Business Media

    Professor FRANCESCA FALLARINO

  15. Effects of intraperitoneal injection of microencapsulated Sertoli cells on chronic and presymptomatic dystrophic mice

    Article • Data in Brief, December 2015, Elsevier

    Prof stefano giovagnoli, Professor FRANCESCA FALLARINO

  16. IDO1 suppresses inhibitor development in hemophilia A treated with factor VIII

    Article • Journal of Clinical Investigation, August 2015, American Society for Clinical Investigation

    Professor FRANCESCA FALLARINO

  17. Long-term stability, functional competence, and safety of microencapsulated specific pathogen-free neonatal porcine Sertoli cells: a potential product for cell transplant therapy

    Article • Xenotransplantation, July 2015, Wiley

    Prof stefano giovagnoli, Professor FRANCESCA FALLARINO, Giovanni Luca

  18. Accumulation of an Endogenous Tryptophan-Derived Metabolite in Colorectal and Breast Cancers

    Article • PLoS ONE, April 2015, PLOS

    Professor FRANCESCA FALLARINO

  19. Stem cells from human amniotic fluid exert immunoregulatory function via secreted indoleamine 2,3‐dioxygenase1

    Article • Journal of Cellular and Molecular Medicine, March 2015, Wiley

    Prof stefano giovagnoli, Professor FRANCESCA FALLARINO

  20. Cytokines in systemic juvenile idiopathic arthritis and haemophagocytic lymphohistiocytosis: tipping the balance between interleukin-18 and interferon-γ

    Article • Rheumatology, March 2015, Oxford University Press (OUP)

    Professor FRANCESCA FALLARINO

  21. In vitro cadmium effects on ECM gene expression in human bronchial epithelial cells

    Article • Cytokine, March 2015, Elsevier

    Professor FRANCESCA FALLARINO

  22. The Pyrazolobenzothiazine Core as a New Chemotype of p38 Alpha Mitogen-Activated Protein Kinase Inhibitors

    Article • Chemical Biology & Drug Design, February 2015, Wiley

    Professor FRANCESCA FALLARINO

  23. LPS-conditioned dendritic cells confer endotoxin tolerance contingent on tryptophan catabolism

    Article • Immunobiology, February 2015, Elsevier

    Professor FRANCESCA FALLARINO

  24. Comparative proteomic analysis of two distinct stem-cell populations from human amniotic fluid

    Article • Molecular BioSystems, January 2015, Royal Society of Chemistry

    Professor FRANCESCA FALLARINO

  25. Tryptophan Feeding of the IDO1-AhR Axis in Host–Microbial Symbiosis

    Article • Frontiers in Immunology, December 2014, Frontiers

    Professor FRANCESCA FALLARINO

  26. Ligand Binding and Functional Selectivity of l-Tryptophan Metabolites at the Mouse Aryl Hydrocarbon Receptor (mAhR)

    Article • Journal of Chemical Information and Modeling, November 2014, American Chemical Society (ACS)

    Professor FRANCESCA FALLARINO, ANTONIO MACCHIARULO

  27. AhR-Mediated, Non-Genomic Modulation of IDO1 Function

    Article • Frontiers in Immunology, October 2014, Frontiers

    Professor FRANCESCA FALLARINO, ANTONIO MACCHIARULO

  28. Forced IDO1 expression in dendritic cells restores immunoregulatory signalling in autoimmune diabetes

    Article • Journal of Cellular and Molecular Medicine, September 2014, Wiley

    Professor Ursula Grohmann, Professor FRANCESCA FALLARINO

  29. AhR: Far more than an environmental sensor

    Article • Cell Cycle, September 2014, Taylor & Francis

    Professor FRANCESCA FALLARINO

  30. Aryl hydrocarbon receptor control of a disease tolerance defence pathway

    Article • Nature, July 2014, Nature

    Professor FRANCESCA FALLARINO, ANTONIO MACCHIARULO

  31. Cinnabarinic acid, an endogenous agonist of type-4 metabotropic glutamate receptor, suppresses experimental autoimmune encephalomyelitis in mice

    Article • Neuropharmacology, June 2014, Elsevier

    Professor FRANCESCA FALLARINO

  32. Distinct and complementary roles for Aspergillus fumigatus ‐specific Tr1 and Foxp3 + regulatory T cells in humans and mice

    Article • Immunology and Cell Biology, May 2014, Wiley

    Professor FRANCESCA FALLARINO

  33. Indoleamine 2,3-Dioxygenase 1 (IDO1) Is Up-Regulated in Thyroid Carcinoma and Drives the Development of an Immunosuppressant Tumor Microenvironment

    Article • The Journal of Clinical Endocrinology & Metabolism, May 2014, Endocrine Society

    Professor FRANCESCA FALLARINO, ANTONIO MACCHIARULO

  34. NEDD4 controls the expression of GUCD1, a protein upregulated in proliferating liver cells

    Article • Cell Cycle, April 2014, Taylor & Francis

    Professor FRANCESCA FALLARINO

  35. On-treatment C-reactive protein and HDL cholesterol levels in patients at intermediate cardiovascular risk: Impact on carotid intima-media thickness

    Article • Life Sciences, September 2013, Elsevier

    Professor FRANCESCA FALLARINO

  36. Tryptophan Catabolites from Microbiota Engage Aryl Hydrocarbon Receptor and Balance Mucosal Reactivity via Interleukin-22

    Article • Immunity, August 2013, Elsevier

    Professor FRANCESCA FALLARINO, Dott Giuseppe Pieraccini

  37. Topical Application of Soluble CD83 Induces IDO-Mediated Immune Modulation, Increases Foxp3+ T Cells, and Prolongs Allogeneic Corneal Graft Survival

    Article • The Journal of Immunology, July 2013, The American Association of Immunologists

    Professor FRANCESCA FALLARINO

  38. High doses of CpG oligodeoxynucleotides stimulate a tolerogenic TLR9–TRIF pathway

    Article • Nature Communications, May 2013, Springer Science + Business Media

    Professor FRANCESCA FALLARINO

  39. Th17/Treg Imbalance in Murine Cystic Fibrosis Is Linked to Indoleamine 2,3-Dioxygenase Deficiency but Corrected by Kynurenines

    Article • American Journal of Respiratory and Critical Care Medicine, March 2013, American Thoracic Society

    Professor FRANCESCA FALLARINO

  40. Cytotoxic T lymphocyte antigen 4-immunoglobulin G is a potent adjuvant for experimental allergen immunotherapy

    Article • Clinical & Experimental Immunology, March 2013, Wiley

    Professor FRANCESCA FALLARINO

  41. A TLR9/TRIF PATHWAY INDUCES TOLERANCE VIA TGF-� AND TRYPTOPHAN CATABOLISM IN PLASMACYTOID DENDRITIC CELLS

    Article • Frontiers in Immunology, January 2013, Frontiers

    Professor FRANCESCA FALLARINO

  42. Jack of all trades: thymosin α1 and its pleiotropy

    Article • Annals of the New York Academy of Sciences, October 2012, Wiley

    Professor FRANCESCA FALLARINO

  43. Targeting metabotropic glutamate receptors in neuroimmune communication

    Article • Neuropharmacology, September 2012, Elsevier

    Professor FRANCESCA FALLARINO

  44. Indoleamine 2,3-dioxygenase: From catalyst to signaling function

    Article • European Journal of Immunology, August 2012, Wiley

    Professor FRANCESCA FALLARINO

  45. A GpC-Rich Oligonucleotide Acts on Plasmacytoid Dendritic Cells To Promote Immune Suppression

    Article • The Journal of Immunology, July 2012, The American Association of Immunologists

    Professor FRANCESCA FALLARINO

  46. Prolongation of skin allograft survival in rats by the transplantation of microencapsulated xenogeneic neonatal porcine Sertoli cells

    Article • Biomaterials, July 2012, Elsevier

    Professor FRANCESCA FALLARINO

  47. TLR3 essentially promotes protective class I-restricted memory CD8+ T-cell responses to Aspergillus fumigatus in hematopoietic transplanted patients

    Article • Blood, December 2011, American Society of Hematology

    Professor FRANCESCA FALLARINO

  48. Indoleamine 2,3-dioxygenase is a signaling protein in long-term tolerance by dendritic cells

    Article • Nature Immunology, July 2011, Nature

    Professor FRANCESCA FALLARINO

  49. Xenograft of Microencapsulated Sertoli Cells Reverses T1DM in NOD Mice by Inducing Neogenesis of Beta-Cells

    Article • Transplantation, December 2010, Wolters Kluwer Health

    Professor FRANCESCA FALLARINO

  50. IDO Upregulates Regulatory T Cells via Tryptophan Catabolite and Suppresses Encephalitogenic T Cell Responses in Experimental Autoimmune Encephalomyelitis

    Article • The Journal of Immunology, October 2010, The American Association of Immunologists

    Professor FRANCESCA FALLARINO

  51. Metabotropic glutamate receptor-4 modulates adaptive immunity and restrains neuroinflammation

    Article • Nature Medicine, July 2010, Nature

    Professor FRANCESCA FALLARINO

  52. Correction: IDO Mediates Tlr9-Driven Protection From Experimental Autoimmune Diabetes

    Article • The Journal of Immunology, June 2010, The American Association of Immunologists

    Professor FRANCESCA FALLARINO

  53. IL-22 defines a novel immune pathway of antifungal resistance

    Article • Mucosal Immunology, May 2010, Nature

    Professor FRANCESCA FALLARINO

  54. Thymosin α1: the regulator of regulators?

    Article • Annals of the New York Academy of Sciences, May 2010, Wiley

    Professor FRANCESCA FALLARINO

  55. Gut CD103+ dendritic cells express indoleamine 2,3-dioxygenase which influences T regulatory/T effector cell balance and oral tolerance induction

    Article • Gut, April 2010, BMJ

    Professor FRANCESCA FALLARINO

  56. Bioactive Long-Term Release from Biodegradable Microspheres Preserves Implanted ALG-PLO-ALG Microcapsules from In Vivo Response to Purified Alginate

    Article • Pharmaceutical Research, December 2009, Springer Science + Business Media

    Prof stefano giovagnoli, Professor FRANCESCA FALLARINO

  57. Intranasally delivered siRNA targeting PI3K/Akt/mTOR inflammatory pathways protects from aspergillosis

    Article • Mucosal Immunology, November 2009, Nature

    Professor FRANCESCA FALLARINO

  58. IDO Mediates TLR9-Driven Protection from Experimental Autoimmune Diabetes

    Article • The Journal of Immunology, October 2009, The American Association of Immunologists

    Professor FRANCESCA FALLARINO

  59. Therapy of experimental type 1 diabetes by isolated Sertoli cell xenografts alone

    Article • Journal of Experimental Medicine, October 2009, Rockefeller University Press

    Professor FRANCESCA FALLARINO

  60. Balancing inflammation and tolerance in vivo through dendritic cells by the commensal Candida albicans

    Article • Mucosal Immunology, May 2009, Nature

    Professor FRANCESCA FALLARINO

  61. Indoleamine 2,3-dioxygenase in infection: the paradox of an evasive strategy that benefits the host

    Article • Microbes and Infection, January 2009, Elsevier

    Professor FRANCESCA FALLARINO

  62. Indoleamine 2,3-dioxygenase (IDO) in inflammation and allergy toAspergillus

    Article • Medical Mycology, January 2009, Oxford University Press (OUP)

    Professor FRANCESCA FALLARINO

  63. SOCS3 drives proteasomal degradation of indoleamine 2,3-dioxygenase (IDO) and antagonizes IDO-dependent tolerogenesis

    Article • Proceedings of the National Academy of Sciences, December 2008, Proceedings of the National Academy of Sciences

    Professor FRANCESCA FALLARINO

  64. Melanoma presenting as circulating tumor cells associated with failed angiogenesis

    Article • Melanoma Research, August 2008, Wolters Kluwer Health

    Professor FRANCESCA FALLARINO

  65. Generation of T cell regulatory activity by plasmacytoid dendritic cells and tryptophan catabolism

    Article • Blood Cells Molecules and Diseases, January 2008, Elsevier

    Professor FRANCESCA FALLARINO

  66. Defective tryptophan catabolism underlies inflammation in mouse chronic granulomatous disease

    Article • Nature, January 2008, Nature

    Professor FRANCESCA FALLARINO

  67. Immunosuppression Via Tryptophan Catabolism: The Role of Kynurenine Pathway Enzymes

    Article • Transplantation, July 2007, Wolters Kluwer Health

    Professor FRANCESCA FALLARINO

  68. Reverse signaling through GITR ligand enables dexamethasone to activate IDO in allergy

    Article • Nature Medicine, April 2007, Nature

    Professor FRANCESCA FALLARINO, Prof Giuseppe Nocentini

  69. Tryptophan Catabolism in IDO+ Plasmacytoid Dendritic Cells

    Article • Current Drug Metabolism, April 2007, Bentham Science Publishers

    Professor FRANCESCA FALLARINO

  70. Innovative extraction procedure for obtaining high pure lycopene from tomato

    Article • European Food Research and Technology, January 2007, Springer Science + Business Media

    Professor FRANCESCA FALLARINO

  71. Tryptophan catabolism generates autoimmune-preventive regulatory T cells

    Article • Transplant Immunology, December 2006, Elsevier

    Professor FRANCESCA FALLARINO

  72. Thymosin  1 activates dendritic cell tryptophan catabolism and establishes a regulatory environment for balance of inflammation and tolerance

    Article • Blood, October 2006, American Society of Hematology

    Professor FRANCESCA FALLARINO

  73. Toward the identification of a tolerogenic signature in IDO-competent dendritic cells

    Article • Blood, April 2006, American Society of Hematology

    Professor FRANCESCA FALLARINO

  74. Toll-like receptor 9-mediated induction of the immunosuppressive pathway of tryptophan catabolism

    Article • European Journal of Immunology, January 2006, Wiley

    Professor FRANCESCA FALLARINO

  75. Mechanisms of CTLA-4-Ig in Tolerance Induction

    Article • Current Pharmaceutical Design, January 2006, Bentham Science Publishers

    Professor FRANCESCA FALLARINO

  76. Enhanced tryptophan catabolism in the absence of the molecular adapter DAP12

    Article • European Journal of Immunology, November 2005, Wiley

    Professor FRANCESCA FALLARINO

  77. Increased GILZ expression in transgenic mice up-regulates Th-2 lymphokines

    Article • Blood, October 2005, American Society of Hematology

    Professor FRANCESCA FALLARINO

  78. Ligand and cytokine dependence of the immunosuppressive pathway of tryptophan catabolism in plasmacytoid dendritic cells

    Article • International Immunology, September 2005, Oxford University Press (OUP)

    Professor FRANCESCA FALLARINO

  79. CD40 ligation prevents onset of tolerogenic properties in human dendritic cells treated with CTLA-4-Ig

    Article • Microbes and Infection, June 2005, Elsevier

    Professor FRANCESCA FALLARINO

  80. The 2004 FASEB Summer Research Conference on Transplant Immunology: Closer to the Goal of Transplant-Specific Tolerance

    Article • American Journal of Transplantation, January 2005, Wiley

    Professor FRANCESCA FALLARINO

  81. CTLA-4–Ig Activates Forkhead Transcription Factors and Protects Dendritic Cells from Oxidative Stress in Nonobese Diabetic Mice

    Article • Journal of Experimental Medicine, October 2004, Rockefeller University Press

    Professor FRANCESCA FALLARINO

  82. CD28 induces immunostimulatory signals in dendritic cells via CD80 and CD86

    Article • Nature Immunology, October 2004, Nature

    Professor FRANCESCA FALLARINO

  83. TOLERANCE, DENDRITIC CELLS AND TRYPTOPHAN

    Article • Shock, March 2004, Wolters Kluwer Health

    Professor FRANCESCA FALLARINO

  84. Modulation of tryptophan catabolism by regulatory T cells

    Article • Nature Immunology, October 2003, Nature

    Professor FRANCESCA FALLARINO

  85. A Defect in Tryptophan Catabolism Impairs Tolerance in Nonobese Diabetic Mice

    Article • Journal of Experimental Medicine, June 2003, Rockefeller University Press

    Professor FRANCESCA FALLARINO

  86. BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1

    Article • Nature Immunology, June 2003, Springer Science + Business Media

    Professor FRANCESCA FALLARINO

  87. Response to von Bubnoff et al.: Still new perspectives on IDO function?

    Article • Trends in Immunology, June 2003, Elsevier

    Professor FRANCESCA FALLARINO

  88. New jobs for an old enzyme: the revival of IDO

    Article • Trends in Immunology, June 2003, Elsevier

    Professor FRANCESCA FALLARINO

  89. Tolerance, DCs and tryptophan: much ado about IDO

    Article • Trends in Immunology, May 2003, Elsevier

    Professor FRANCESCA FALLARINO

  90. Tryptophan Catabolism in Nonobese Diabetic Mice

    Article • January 2003, Springer Science + Business Media

    Professor FRANCESCA FALLARINO

  91. T Cell Apoptosis by Kynurenines

    Article • January 2003, Springer Science + Business Media

    Professor FRANCESCA FALLARINO

  92. CTLA-4–Ig regulates tryptophan catabolism in vivo

    Article • Nature Immunology, September 2002, Springer Science + Business Media

    Professor FRANCESCA FALLARINO

  93. T cell apoptosis by tryptophan catabolism

    Article • Cell Death and Differentiation, September 2002, Nature

    Professor FRANCESCA FALLARINO

  94. Transplantation and the CD28/CTLA4/B7 pathway

    Article • Transplantation Proceedings, February 2001, Elsevier

    Professor FRANCESCA FALLARINO

  95. Improved efficacy of dendritic cell vaccines and successful immunization with tumor antigen peptide-pulsed peripheral blood mononuclear cells by coadministration of recombinant murine interleukin-12

    Article • International Journal of Cancer, January 1999, Wiley

    Professor FRANCESCA FALLARINO

  96. B7-1 Engagement of Cytotoxic T Lymphocyte Antigen 4 Inhibits T Cell Activation in the Absence of CD28

    Article • Journal of Experimental Medicine, July 1998, Rockefeller University Press

    Professor FRANCESCA FALLARINO

  97. Antigen-specific regression of established tumors induced by active immunization with irradiated IL-12- but not B7-1-transfected tumor cells

    Article • International Immunology, September 1997, Oxford University Press (OUP)

    Professor FRANCESCA FALLARINO

  98. Receptors and Pathways in Innate Antifungal Immunity

    Article • Springer Science + Business Media

    Professor FRANCESCA FALLARINO