All Stories

  1. Bioguided Identification of Polymethoxyflavones as Novel Vascular CaV1.2 Channel Blockers from Citrus Peel
  2. Anti-Inflammatory and Antinociceptive Properties of the Quercetin-3-Oleate AV2, a Novel FFAR1 Partial Agonist
  3. Exploring the chemical space around chrysin to develop novel vascular CaV1.2 channel blockers, promising vasorelaxant agents
  4. Sensory Evaluation and Consumers’ Acceptance of a Low Glycemic and Gluten-Free Carob-Based Bakery Product
  5. Screening of the antioxidant and vasorelaxant activity of wine waste ultrasonic extracts, and HRMS targeted and semi-targeted profiling of glycosylated polyphenols vs free polyphenols
  6. Plant-Derived Exosomes: Nano-Inducers of Cross Kingdom Regulations
  7. Exploiting Glycyrrhiza glabra L. (Licorice) Flavanones: Licoflavanone’s Impact on Breast Cancer Cell Bioenergetics
  8. Formulation of Antioxidant Gummies Based on Gelatin Enriched with Citrus Fruit Peels Extract
  9. Synthetic derivatives of natural cinnamic acids as potential anti‐colorectal cancer agents
  10. Synthesis and Characterization of a Biopolymer Pectin/Ethanolic Extract from Olive Mill Wastewater: In Vitro Safety and Efficacy Tests on Skin Wound Healing
  11. Formulation of A Gluten-Free Carob-Based Bakery Product: Evaluation of Glycemic Index, Antioxidant Activity, Rheological Properties, and Sensory Features
  12. Unripe carob pods: an innovative source of antioxidant molecules for the preparation of high-added value gummies
  13. Development of 1‐(2‐aminophenyl)pyrrole‐based amides acting as human topoisomerase I inhibitors
  14. In Silico-Guided Rational Drug Design and Synthesis of Novel 4-(Thiophen-2-yl)butanamides as Potent and Selective TRPV1 Agonists
  15. Wine Lees as Source of Antioxidant Molecules: Green Extraction Procedure and Biological Activity
  16. Natural Compounds and Biopolymers-Based Hydrogels Join Forces to Promote Wound Healing
  17. Lipoic/Capsaicin-Related Amides: Synthesis and Biological Characterization of New TRPV1 Agonists Endowed with Protective Properties against Oxidative Stress
  18. Chrysin: A polyedric flavone as a tool to explore new phytotherapeutic applications and drug design
  19. Development of Quercetin-DHA Ester-Based Pectin Conjugates as New Functional Supplement: Effects on Cell Viability and Migration
  20. Novel Labdane Diterpenes-Based Synthetic Derivatives: Identification of a Bifunctional Vasodilator That Inhibits CaV1.2 and Stimulates KCa1.1 Channels
  21. Kefir Enriched with Carob (Ceratonia siliqua L.) Leaves Extract as a New Ingredient during a Gluten-Free Bread-Making Process
  22. Editorial: Design, Synthesis, and Preclinical Testing of Innovative Anti-Cancer Compounds With a High Level of Selectivity of Action and Low Toxicity
  23. Milk kefir enriched with inulin‐grafted seed extract from white wine pomace: chemical characterisation, antioxidant profile and in vitro gastrointestinal digestion
  24. Ultrasound-Assisted Extraction, Chemical Characterization, and Impact on Cell Viability of Food Wastes Derived from Southern Italy Autochthonous Citrus Fruits
  25. A Tara Gum/Olive Mill Wastewaters Phytochemicals Conjugate as a New Ingredient for the Formulation of an Antioxidant-Enriched Pudding
  26. Green Synthesis of New Pyrrolo [1,2-a] quinoxalines as Antiproliferative Agents in GPER-expressing Breast Cancer Cells
  27. Design, synthesis and in vitro biological evaluation of a novel class of anti-adenovirus agents based on 3-amino-1,2-propanediol
  28. FFAR1/GPR40: One target, different binding sites, many agonists, no drugs, but a continuous and unprofitable tug-of-war between ligand lipophilicity, activity, and toxicity
  29. 7-Docosahexaenoyl-Quercetin
  30. GPR120/FFAR4 Pharmacology: Focus on Agonists in Type 2 Diabetes Mellitus Drug Discovery
  31. A multitarget semi-synthetic derivative of the flavonoid morin with improved in vitro vasorelaxant activity: Role of CaV1.2 and KCa1.1 channels
  32. Pinocembrin and its linolenoyl ester derivative induce wound healing activity in HaCaT cell line potentially involving a GPR120/FFA4 mediated pathway
  33. Nanotechnologies: An Innovative Tool to Release Natural Extracts with Antimicrobial Properties
  34. Design, synthesis and pharmacological evaluation of ester-based quercetin derivatives as selective vascular KCa1.1 channel stimulators
  35. New Oleoyl Hybrids of Natural Antioxidants: Synthesis and In Vitro Evaluation as Inducers of Apoptosis in Colorectal Cancer Cells
  36. Formulation of New Baking (+)-Catechin Based Leavening Agents: Effects on Rheology, Sensory and Antioxidant Features during Muffin Preparation
  37. Serinol-Based Benzoic Acid Esters as New Scaffolds for the Development of Adenovirus Infection Inhibitors: Design, Synthesis, and In Vitro Biological Evaluation
  38. Design, Synthesis and In Vitro Experimental Validation of Novel TRPV4 Antagonists Inspired by Labdane Diterpenes
  39. Quality parameters, chemical compositions and antioxidant activities of Calabrian (Italy) monovarietal extra virgin olive oils from autochthonous (Ottobratica) and allochthonous (Coratina, Leccino, and Nocellara Del Belice) varieties
  40. Exploration of piperazine-derived thioureas as antibacterial and anti-inflammatory agents. In vitro evaluation against clinical isolates of colistin-resistant Acinetobacter baumannii
  41. Improving Kefir Bioactive Properties by Functional Enrichment with Plant and Agro-Food Waste Extracts
  42. Synthetic bioactive olivetol-related amides: The influence of the phenolic group in cannabinoid receptor activity
  43. Mantonico and Pecorello Grape Seed Extracts: Chemical Characterization and Evaluation of In Vitro Wound-Healing and Anti-Inflammatory Activities
  44. Valorisation of olive oil pomace extracts for a functional pear beverage formulation
  45. Vasorelaxant Effects Induced by Red Wine and Pomace Extracts of Magliocco Dolce cv.
  46. Sweeteners
  47. A Walk in Nature: Sesquiterpene Lactones as Multi-Target Agents Involved in Inflammatory Pathways
  48. Triazolopyrimidinium salts: discovery of a new class of agents for cancer therapy
  49. Sangiovese cv Pomace Seeds Extract-Fortified Kefir Exerts Anti-Inflammatory Activity in an In Vitro Model of Intestinal Epithelium Using Caco-2 Cells
  50. Optimization of piperazine-derived ureas privileged structures for effective antiadenovirus agents
  51. 3-Amino-alkylated indoles: unexplored green products acting as anti-inflammatory agents
  52. Quercetin and its Natural Sources in Wound Healing Management
  53. Advances in the Tyrosinase Inhibitors from Plant Source
  54. Corrigendum to “Synthesis and characterization of a (+)-catechin and L-(+)-ascorbic acid cocrystal as a new functional ingredient for tea drinks” [Heliyon 5 (8) (August 2019) e02291]
  55. Quercetin‐3‐Oleate Contributes to Skin Wound Healing Targeting FFA1/GPR40
  56. Synthesis and characterization of a (+)-catechin and L-(+)-ascorbic acid cocrystal as a new functional ingredient for tea drinks
  57. In vitro anti-proliferative and anti-bacterial properties of new C7 benzoate derivatives of pinocembrin
  58. Quercetin-3-oleoyl derivatives as new GPR40 agonists: Molecular docking studies and functional evaluation
  59. Antioxidant and Anti-Inflammatory Activities of Flavanones from Glycyrrhiza glabra L. (licorice) Leaf Phytocomplexes: Identification of Licoflavanone as a Modulator of NF-kB/MAPK Pathway
  60. Vasoactivity of Mantonico and Pecorello grape pomaces on rat aorta rings: An insight into nutraceutical development
  61. Corrigendum to “Naturally occurring sesquiterpene lactones and their semi-synthetic derivatives modulate PGE2 levels by decreasing COX2 activity and expression” [Heliyon 5 (3) (March 2019) e01366]
  62. Investigation of TNBC in vitro Antiproliferative Effects of Versatile Pirrolo[1,2-a]quinoxaline Compounds
  63. Naturally occurring sesquiterpene lactones and their semi-synthetic derivatives modulate PGE2 levels by decreasing COX2 activity and expression
  64. Discovery of 1,4-Naphthoquinones as a New Class of Antiproliferative Agents Targeting GPR55
  65. Comparison of the in vitro wound healing activity of diffetent Calabrian honey
  66. Autochthonous white grape pomaces as bioactive source for functional jams
  67. Quercetin-3-oleate
  68. Bio-Catalytic Synthesis of Quercetin-3-Oleate
  69. Rational drug design and synthesis of new α-Santonin derivatives as potential COX-2 inhibitors
  70. An ancient remedial repurposing: synthesis of new pinocembrin fatty acid acyl derivatives as potential antimicrobial/anti-inflammatory agents
  71. 2,3-Dihydroquinazolin-4(1H)-one as a privileged scaffold in drug design
  72. Anti-inflammatory and Antioxidant Agents from Salvia Genus (Lamiaceae): An Assessment of the Current State of Knowledge
  73. From the hive: Honey, a novel weapon against cancer
  74. Quercetin/oleic acid-based G-protein-coupled receptor 40 ligands as new insulin secretion modulators
  75. From Vegetable Waste to New Agents for Potential Health Applications: Antioxidant Properties and Effects of Extracts, Fractions and Pinocembrin from Glycyrrhiza glabra L. Aerial Parts on Viability of Five Human Cancer Cell Lines
  76. Synthesis and anti-proliferative activity of a small library of 7-substituted 5H-pyrrole [1,2-a][3,1]benzoxazin-5-one derivatives
  77. Identification of Breast Cancer Inhibitors Specific for G Protein‐Coupled Estrogen Receptor (GPER)‐Expressing Cells
  78. Quercetin and derivatives: useful tools in inflammation and pain management
  79. Synthesis and Experimental Validation of New PDI Inhibitors with Antiproliferative Activity
  80. Structure–activity relationships for the synthesis of selective cyclooxygenase 2 inhibitors: an overview (2009–2016)
  81. Design and Synthesis of New Transient Receptor Potential Vanilloid Type-1 (TRPV1) Channel Modulators: Identification, Molecular Modeling Analysis, and Pharmacological Characterization of theN-(4-Hydroxy-3-methoxybenzyl)-4-(thiophen-2-yl)butanamide, a S...
  82. TRPV1-FAAH-COX: TheCouples Gamein Pain Treatment
  83. Homology Modeling, Validation and Dynamics of the G Protein-coupled Estrogen Receptor 1 (GPER-1)
  84. Antitubulinic effect of New Fluorazone Derivatives on Melanoma Cells
  85. Identification and Preclinical Evaluation of SC144, a Novel Pyrroloquinoxaline Derivative with Broad-Spectrum Anticancer Activity
  86. Identification of novel 2-(1H-indol-1-yl)-benzohydrazides CXCR4 ligands impairing breast cancer growth and motility
  87. Identification of two benzopyrroloxazines acting as selective GPER antagonists in breast cancer cells and cancer-associated fibroblasts
  88. Outdoor Air Pollutants
  89. Synthesis and Evaluation of Indole Based Molecules for Treatment of Oxidative Stress Related Diseases
  90. Structure–affinity relationships and pharmacological characterization of new alkyl-resorcinol cannabinoid receptor ligands: Identification of a dual cannabinoid receptor/TRPA1 channel agonist
  91. Active manganese dioxide promoted cyclization of ortho-(1H-pyrrol-1-yl)aryl and heteroaryl carboxylic acids to 5H-pyrrolo[1,2-a][3,1]benzoxazin-5-one derivatives
  92. Design and Synthesis of 3-Carbamoylbenzoic Acid Derivatives as Inhibitors of Human Apurinic/Apyrimidinic Endonuclease 1 (APE1)
  93. ChemInform Abstract: Convenient Synthesis of Fluorazone Derivatives by One-Pot Pyrrolation/Cyclization of Anthranilic Acids.
  94. Resorcinol-sn-Glycerol Derivatives: Novel 2-Arachidonoylglycerol Mimetics Endowed with High Affinity and Selectivity for Cannabinoid Type 1 Receptor
  95. Convenient synthesis of fluorazone derivatives by one-pot pyrrolation/cyclization of anthranilic acids
  96. ChemInform Abstract: Direct Cyclization of ortho-(1H-Pyrrol-1-yl)aryl and Heteroaryl Carboxylic Acids into Fused Pyrrolizinones.
  97. Direct cyclization of ortho-(1H-pyrrol-1-yl)aryl and heteroaryl carboxylic acids into fused pyrrolizinones
  98. ChemInform Abstract: Efficient Synthesis of 9H-Pyrrolo[1,2-a]indol-9-one Derivatives Based on Active Manganese Dioxide Promoted Intramolecular Cyclization.
  99. Efficient synthesis of 9H-pyrrolo[1,2-a]indol-9-one derivatives based on active manganese dioxide promoted intramolecular cyclization
  100. Synthesis and biological evaluation of novel hydrazide based cytotoxic agents
  101. Discovery of a novel quinoxalinhydrazide with a broad-spectrum anticancer activity
  102. Discovery of Novel Anticancer Compounds Based on a Quinoxalinehydrazine Pharmacophore
  103. Naphthoxazepine Inhibitors of HIV-1 Integrase: Synthesis and Biological Evaluation
  104. Synthesis and antitumor activities of a series of novel quinoxalinhydrazides
  105. An approach to the stereo-controlled synthesis of polycyclic derivatives of l-4-thiazolidinecarboxylic acid active against HIV-1 integrase
  106. Discovery of Small Molecule Integrin αvβ3 Antagonists as Novel Anticancer Agents
  107. Synthesis of novel thiazolothiazepine based HIV-1 integrase inhibitors
  108. Multivariate least squares regression applied to the spectrophotometric analysis of manidipine and its main photoproduct
  109. Synthesis and Pharmacological Evaluation of Potent and Highly Selective D 3 Receptor Ligands:  Inhibition of Cocaine-Seeking Behavior and the Role of Dopamine D 3 /D 2 Receptors †
  110. Quinoxalinylethylpyridylthioureas (QXPTs) as Potent Non-Nucleoside HIV-1 Reverse Transcriptase (RT) Inhibitors. Further SAR Studies and Identification of a Novel Orally Bioavailable Hydrazine-Based Antiviral Agent